Twinfilin-1

Overview


Name	Twinfilin-1
Smed ID	SMED30015706
Length (bp)	1248

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Twinfilin-1 (SMED30015706) t-SNE clustered cells

Violin plots show distribution of expression levels for Twinfilin-1 (SMED30015706) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Twinfilin-1 (SMED30015706) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Twinfilin-1 (SMED30015706) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30015706

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30015706	h1SMcG0011438	Contig2453	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30015706	h1SMcG0011438	Contig2453	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30015706	h1SMcG0011438	Contig2453	GPL15192	PMID:23079596 Forsthoefel et al., 2012
protonephridia	SMED30015706	h1SMcG0011438	dd_Smed_v4_2563_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30015706	h1SMcG0011438	dd_Smed_v4_2563_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30015706	h1SMcG0011438	dd_Smed_v4_2563_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30015706	h1SMcG0011438	dd_Smed_v4_2563_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30015706	h1SMcG0011438	dd_Smed_v4_2563_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Twinfilin-1 vs. Ensembl Human
Match: TWF1 (twinfilin actin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9620])

HSP 1 Score: 243.432 bits (620), Expect = 1.076e-76
Identity = 119/320 (37.19%), Postives = 206/320 (64.38%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ ++ +   +++ DYD  +   L+  Q CYIL+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T +G     +TL+   FP +    + L K +N +++++++ I+I  E  I  +++ +EL    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG+T S++ERMLYSSCK+  LE+++ + Q+++ RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELK--DLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGD--ELTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Human
Match: TWF2 (twinfilin actin binding protein 2 [Source:HGNC Symbol;Acc:HGNC:9621])

HSP 1 Score: 237.654 bits (605), Expect = 1.635e-74
Identity = 119/319 (37.30%), Postives = 194/319 (60.82%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M H +GI ++ +L +    ++   +R I+V IE+E LV+    +  G ++ DYDR +   L   Q CY+LYR D+    G EWLFL W PDN+ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL ++GY K+  S +AP PLT AE+EL +I+ NE +T +      +TL+   FP        L +     +++++M +++++ETI+   ++       L S V  D  RY+ + ++HT E +  E ++FIY+MPG+  S+KERMLYSSCK+  L+ ++ +F L I +K+E+  GD ++L  + L  ++HP Q
Sbjct:    1 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEP-TDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEI--GDGAELTAEFLYDEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Human
Match: TWF1 (twinfilin actin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9620])

HSP 1 Score: 236.498 bits (602), Expect = 5.210e-74
Identity = 117/327 (35.78%), Postives = 204/327 (62.39%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNER---------ETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ ++ +   +++ DYD  +   L+  Q CYIL+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE          +  +    +TL+   FP +    + L K +N +++++++ I+I  E  I  +++ +EL    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG+T S++ERMLYSSCK+  LE+++ + Q+++ RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELK--DLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGD--ELTADFLYEEVHPKQ 323

[Close]

BLAST of Twinfilin-1 vs. Ensembl Human
Match: TWF2 (twinfilin actin binding protein 2 [Source:HGNC Symbol;Acc:HGNC:9621])

HSP 1 Score: 174.866 bits (442), Expect = 1.541e-51
Identity = 89/254 (35.04%), Postives = 147/254 (57.87%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPI 814
            M H +GI ++ +L +    ++   +R I+V IE+E LV+    +  G ++ DYDR +   L   Q CY+LYR D+    G EWLFL W PDN+ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL ++GY K+  S +AP PLT AE+EL +I+ NE +T +      +TL+   FP        L +     +++++M +++++ETI+   ++       L S V  D  RY+ + ++HT E +  E +
Sbjct:    1 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPT-DVAQLPSRVPRDAARYHFFLYKHTHEGDPLESV 253

[Close]

BLAST of Twinfilin-1 vs. Ensembl Human
Match: TWF1 (twinfilin actin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9620])

HSP 1 Score: 167.548 bits (423), Expect = 2.937e-48
Identity = 90/269 (33.46%), Postives = 160/269 (59.48%), Query Frame = 2

Query:   44 RKFNKMTHASGIRSSIKL-----TDDIK----FSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPI 814
            R+FN   + + I S  ++     ++D+K     ++  K R +++ IENE LV+ ++ +   +++ DYD  +   L+  Q CYIL+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T +G     +TL+   FP +    + L K +N +++++++ I+I  E  I  +++ +EL    L   +  D  RY+ + ++H+ E +  E I
Sbjct:   25 RQFNMQLYLTSIISWFEIGQPAASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELK--DLPKRIPKDSARYHFFLYKHSHEGDYLESI 291

[Close]

BLAST of Twinfilin-1 vs. Ensembl Celegans
Match: twf-2 (TWinFilin actin binding protein homolog [Source:UniProtKB/TrEMBL;Acc:Q20173])

HSP 1 Score: 182.185 bits (461), Expect = 8.819e-54
Identity = 105/320 (32.81%), Postives = 172/320 (53.75%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDS 1018
            M   +GIR++  L + +   K+ K+R I++ + NE +          N+  D+  C+   +   + C+IL+R +  T    EW+ + +V D A +REKML A+T +T K EFG+ Y   +    D  DL  + +  + ++K+   P++  E+EL   ++ ER      G + +K   FP   N  E L + ++ ++ F+++S++   E IK + +   L    L S V  DKPRY  Y F HT+E    +  +FIY++P   SS+KERMLYSSCK PFL   Q+++ + I  K+EV + D  DL    LL  IHP  +++
Sbjct:    1 MACQTGIRANAALRNALNLGKQAKLRLIKIVVNNEEMTPNYEFAGTANWRDDWRACLPDCVDAYEPCFILFRLNTIT----EWVLITFVDDRAPVREKMLLAATCATFKSEFGQCYIEHEKHVTDLKDLTLNAFEAWLKAKTELGPMSEVERELHNAQQ-ERAAIAHAGPQHMKGVAFPVDRNAEEALRQLASQKLSFVQLSVDTLNEAIKLEGTLESLEPSQLASKVPRDKPRYTFYNFDHTWEGVPQQCTLFIYSLPSSGSSIKERMLYSSCKGPFLSAAQNQYGVVITNKMEVDARD--DLSEKALLEVIHPLPVEA 313

[Close]

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDS 1018
            M   +GIR++  L + +   K+ K+R I++ + NE +          N+  D+  C+   +   + C+IL+R +  T    EW+ + +V D A +REKML A+T +T K EFG+ Y   +    D  DL  + +  + ++K+   P++  E+EL   ++ ER      G + +K   FP   N  E L + ++ ++ F+++S++   E IK + +   L    L S V  DKPRY  Y F HT+E    +  +FIY++P   SS+KERMLYSSCK PFL   Q+++ + I  K+EV + D  DL    LL  IHP  +++
Sbjct:    1 MACQTGIRANAALRNALNLGKQAKLRLIKIVVNNEEMTPNYEFAGTANWRDDWRACLPDCVDAYEPCFILFRLNTIT----EWVLITFVDDRAPVREKMLLAATCATFKSEFGQCYIEHEKHVTDLKDLTLNAFEAWLKAKTELGPMSEVERELHNAQQ-ERAAIAHAGPQHMKGVAFPVDRNAEEALRQLASQKLSFVQLSVDTLNEAIKLEGTLESLEPSQLASKVPRDKPRYTFYNFDHTWEGVPQQCTLFIYSLPSSGSSIKERMLYSSCKGPFLSAAQNQYGVVITNKMEVDARD--DLSEKALLEVIHPLPVEA 313

[Close]

BLAST of Twinfilin-1 vs. Ensembl Fly
Match: twf (gene:FBgn0038206 transcript:FBtr0082891)

HSP 1 Score: 231.491 bits (589), Expect = 1.555e-72
Identity = 123/325 (37.85%), Postives = 194/325 (59.69%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGF--PPTDNLIEELTKFSNGEIDFLEMSIEIDKETIK-NDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKP 1024
            M+H +GIR++ +L      +K  K R I+V IENE L      + + ++E DYD+ I   L+ D  CYILYR D    LG+ WL + W PD ASIR+KM+YAST++T+K EFG +Y  E++      +    GY ++++  +AP PLT  E+EL E+++ E  T +    R     G   P ++  +  +     G+ D+L+  I++++E I  + ++K EL+   L   V  D  RY+L+ FRHT E + +E  +F+Y+MPG++ SV+ERM+YSSCKAPFL+ L +   + + +KLE+ SG  S+L    L  ++HP +I  +P
Sbjct:    1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDVPCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECTLEGYRRHKQDFAAPAPLTSREEELKELRKTEVHTEINTNTRHQTLGGINCPLSEATVAAVQDLVRGKHDYLQFRIDLEEEQIHVSRAAKVELA--DLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMPGYSCSVRERMMYSSCKAPFLDELAA-LGVEVVKKLEIDSG--SELTEAFLQDELHPKKILHRP 320

[Close]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Match: twf1b (twinfilin actin-binding protein 1b [Source:ZFIN;Acc:ZDB-GENE-040711-3])

HSP 1 Score: 235.343 bits (599), Expect = 9.932e-74
Identity = 116/319 (36.36%), Postives = 198/319 (62.07%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI+++ ++ +    ++  + R I+V IENE LV+    +A   ++ ++D C+   ++ D   Y+L+R D +   G+EW+FL W PD++ +R+KMLYA+TR+T+K+EFG  +  E+I G  K D+  +GY KY  S++AP PLT AE+EL +IK NE +T   +   Q+TL+   FP   + I+ L +F +  I+++++ I+   E+IK  S  +      L   +  D  RY+ + ++H+ E +  E  +FIY+MPG+  S+KERMLYSSCK P ++ ++    + I +KLE+ +GD  +L +D +  ++HP Q
Sbjct:    1 MSHQTGIQATGEVKEIFAKARNGEYRLIKVVIENEKLVLGGSKRAAKKWDQEWDGCVLPLVEDDMPSYLLFRLDTTNNQGYEWVFLAWSPDHSPVRQKMLYAATRATLKKEFGGGHIKEEIFGTVKDDVSLNGYKKYLSSQAAPLPLTAAEEELRQIKLNELQTDVHVDTKQQTLQGVAFPMQRDAIQALEQFRDKRINYVQLEIDFPNESIKL-SGTAPTDLKDLPKRIPKDAARYHFFLYKHSHEGDYLESTVFIYSMPGYKCSIKERMLYSSCKNPLIDTVERNLGIEIAKKLEIDNGD--ELTSDFMYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Match: twf2b (twinfilin actin-binding protein 2b [Source:ZFIN;Acc:ZDB-GENE-050522-238])

HSP 1 Score: 224.942 bits (572), Expect = 1.224e-69
Identity = 118/345 (34.20%), Postives = 201/345 (58.26%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERE--------TALGDGQR---------TLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPP-----QIDSKPK 1027
            M+H +GI ++  L + +  ++    R +++ I +E LV+  + +   +++ DYD C+   L   + CYILYR D+  +LG+EWLF+ W PD + +R KM+YA+TR+T+K+EFG S+  +++ G  + D+ + GYL++  S S P PLT AEQ+L +IK  E E        T  G G+          TL+   FP  +     L +F +  I+++++ ++ ++ETI+   + S      L S +  D PRY+ + ++H  + +  E ++FIY+MPG++ S+KERMLYSSCK   L+ ++ ++ + I +K+E+ SGD   L  D L  +++P      Q  SKPK
Sbjct:    1 MSHQTGIHATSDLREFLIKARRGAFRALKIVIRSEQLVLGAYREVSQSWDQDYDACVLPMLDGLEPCYILYRLDSHNQLGYEWLFISWSPDQSPVRLKMVYAATRATLKKEFGGSHINDEVFGTVQEDISFQGYLRHLSSSSCPAPLTTAEQQLHQIKITEDERRIVRPVATVSGQGKTEINVESKNPTLQGLAFPLQEEAKHALQQFKHKRINYIQLRLDTERETIELVHT-SPTETKELPSRIPTDAPRYHFFLYKHAHQGQPLEAVVFIYSMPGYSCSIKERMLYSSCKNRLLDEVERDYHIEIAKKMEIESGD--GLTEDFLYEEVYPKHHALRQAFSKPK 342

[Close]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Match: twf2b (twinfilin actin-binding protein 2b [Source:ZFIN;Acc:ZDB-GENE-050522-238])

HSP 1 Score: 223.787 bits (569), Expect = 4.725e-69
Identity = 119/350 (34.00%), Postives = 203/350 (58.00%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIK-------RNERE------TALGDGQR---------TLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPP-----QIDSKPK 1027
            M+H +GI ++  L + +  ++    R +++ I +E LV+  + +   +++ DYD C+   L   + CYILYR D+  +LG+EWLF+ W PD + +R KM+YA+TR+T+K+EFG S+  +++ G  + D+ + GYL++  S S P PLT AEQ+L +IK       R+ER       T  G G+          TL+   FP  +     L +F +  I+++++ ++ ++ETI+   + S      L S +  D PRY+ + ++H  + +  E ++FIY+MPG++ S+KERMLYSSCK   L+ ++ ++ + I +K+E+ SGD   L  D L  +++P      Q  SKPK
Sbjct:    1 MSHQTGIHATSDLREFLIKARRGAFRALKIVIRSEQLVLGAYREVSQSWDQDYDACVLPMLDGLEPCYILYRLDSHNQLGYEWLFISWSPDQSPVRLKMVYAATRATLKKEFGGSHINDEVFGTVQEDISFQGYLRHLSSSSCPAPLTTAEQQLHQIKITEDKVARDERRIVRPVATVSGQGKTEINVESKNPTLQGLAFPLQEEAKHALQQFKHKRINYIQLRLDTERETIELVHT-SPTETKELPSRIPTDAPRYHFFLYKHAHQGQPLEAVVFIYSMPGYSCSIKERMLYSSCKNRLLDEVERDYHIEIAKKMEIESGD--GLTEDFLYEEVYPKHHALRQAFSKPK 347

[Close]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Match: twf2a (twinfilin actin binding protein 2 [Source:NCBI gene;Acc:100310784])

HSP 1 Score: 208.764 bits (530), Expect = 1.671e-63
Identity = 111/294 (37.76%), Postives = 180/294 (61.22%), Query Frame = 2

Query:  134 RCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNE--RETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            R IQV I +E LV+  + +   +++ DYD  +   L P + CYILYR D+    G+EWLF+ W PD + +R+KMLYA+TR+T+K+EFG  +  +++ G  + D+   GYL++  S SAP PLT+AEQEL  IK  E   E ++    +TL+   FP        L + +   I+++++ ++ +KETI +    S      L   +  D PRY+ + ++H+ E +  E ++FIY+MPG++ S+KERMLYSSCK+  L+ ++ +F L + +KLE+ SG+  +L  + L  ++HP Q
Sbjct:   24 RLIQVLIRDEQLVLGAYREPRHSWDKDYDPVLLPLLDPLEPCYILYRLDSKNAQGYEWLFISWSPDQSPVRQKMLYAATRATVKKEFGGGHVKDEMFGTVEEDICLQGYLRHITSCSAPAPLTVAEQELQRIKITEVKAEISVDPKHQTLQGLAFPLQAEAKRALKQLAERRINYIQLKLDTEKETI-DLVHTSPTDIRDLPCRIPLDTPRYHFFLYKHSHEGDYLESVVFIYSMPGYSCSIKERMLYSSCKSRLLDEVERDFHLEVAKKLEIDSGE--ELTEEYLYDEVHPKQ 314

[Close]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Match: twf2b (twinfilin actin-binding protein 2b [Source:ZFIN;Acc:ZDB-GENE-050522-238])

HSP 1 Score: 205.682 bits (522), Expect = 3.147e-62
Identity = 113/345 (32.75%), Postives = 193/345 (55.94%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERE--------TALGDGQR---------TLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPP-----QIDSKPK 1027
            M+H +GI ++  L + +  ++    R +++ I +E LV+  + +   +++ DYD C+   L   + CYILYR D+  +LG+EWLF+ W PD + +R KM+Y        +EFG S+  +++ G  + D+ + GYL++  S S P PLT AEQ+L +IK  E E        T  G G+          TL+   FP  +     L +F +  I+++++ ++ ++ETI+   + S      L S +  D PRY+ + ++H  + +  E ++FIY+MPG++ S+KERMLYSSCK   L+ ++ ++ + I +K+E+ SGD   L  D L  +++P      Q  SKPK
Sbjct:    1 MSHQTGIHATSDLREFLIKARRGAFRALKIVIRSEQLVLGAYREVSQSWDQDYDACVLPMLDGLEPCYILYRLDSHNQLGYEWLFISWSPDQSPVRLKMVY--------KEFGGSHINDEVFGTVQEDVSFQGYLRHLSSSSCPAPLTTAEQQLHQIKITEDERRIVRPVATVSGQGKTEINVESKNPTLQGLAFPLQEEAKHALQQFKHKRINYIQLRLDTERETIELVHT-SPTETKELPSRIPTDAPRYHFFLYKHAHQGQPLEAVVFIYSMPGYSCSIKERMLYSSCKNRLLDEVERDYHIEIAKKMEIESGD--GLTEDFLYEEVYPKHHALRQAFSKPK 334

[Close]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Match: dcdc2b (doublecortin domain containing 2B [Source:Xenbase;Acc:XB-GENE-5892141])

HSP 1 Score: 229.565 bits (584), Expect = 2.362e-71
Identity = 114/320 (35.62%), Postives = 196/320 (61.25%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IE+E L +   +K   ++E +YD  I   L+  Q CYI+YR D+    G EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  E++ G  K D+   GY KY   +S+P PLT+AE+EL +IK  E +  +G     +TL+   FP      + L +     ++++++ I+I  ET I  D++ +E+    L   +  D  RY+ + ++H+ E +  +  +FIY+MPG+T S++ERMLYSSCK+P L+++++   + I RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVLEMFARARNGKYRLLKLDIEDEQLTVTACEKPASSWEQEYDSLILPLLEDKQPCYIMYRLDSQNAQGFEWIFIAWSPDHSHVRQKMLYAATRATVKKEFGGGHIKEELFGTVKDDISLKGYYKYLACQSSPAPLTMAEEELRQIKIKETQVDIGVDTKHQTLQGIAFPIEKAAFQALEQLREKRLNYVQLKIDIKNETIILADTTNTEVR--DLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMPGYTCSIRERMLYSSCKSPLLDVIENRLLMEIARKIEIDNGD--ELTPDFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Match: agxt2 (alanine--glyoxylate aminotransferase 2 [Source:Xenbase;Acc:XB-GENE-993827])

HSP 1 Score: 228.409 bits (581), Expect = 5.354e-71
Identity = 120/320 (37.50%), Postives = 194/320 (60.62%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSK-SELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M H +GI ++ +L D    ++   IR I+V IE E LV+ +H + +  ++ DYD  +   L   + CYILYR D+    G+EW+FL W PD++ +R KMLYA+TR+T+K+EFG  +  ++I G  K D+   GY K+  S +AP PLT AE+EL EIK NE +T +     Q+TL+   FP        +      +I+++++ ++++KET+    +K +EL    L   +  D  RY+ + ++H+ E +  E ++FIY+MPG+  S+KERMLYSSCK   L+ ++ +FQL I +K+E+  G  ++L  + L  ++HP Q
Sbjct:    1 MAHQTGIHATPELKDFFAKARNGSIRLIKVIIEEEQLVLGSHKELKHAWDQDYDALVLPLLDESEPCYILYRLDSQNAQGYEWIFLSWSPDHSPVRLKMLYAATRATVKKEFGGGHIKDEIFGTLKEDIALGGYKKHVSSCAAPAPLTAAERELQEIKINEVKTEISVESKQQTLQGLSFPLRPEAEGAILLLKQKKINYIQLRLDLEKETVDLVHTKHTELK--DLPGRIPQDTARYHFFLYKHSHEGDHLESVVFIYSMPGYKCSIKERMLYSSCKNKLLDSVEQDFQLEIVKKIEIEDG--AELTDEFLYDEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Match: dcdc2b (doublecortin domain containing 2B [Source:Xenbase;Acc:XB-GENE-5892141])

HSP 1 Score: 223.787 bits (569), Expect = 3.845e-69
Identity = 115/322 (35.71%), Postives = 193/322 (59.94%), Query Frame = 2

Query:   62 THASGIRSSIKLTDDIKF---SKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            TH  G R  I   D ++    ++  K R +++ IE+E L +   +K   ++E +YD  I   L+  Q CYI+YR D+    G EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  E++ G  K D+   GY KY   +S+P PLT+AE+EL +IK  E +  +G     +TL+   FP      + L +     ++++++ I+I  ET I  D++ +E+    L   +  D  RY+ + ++H+ E +  +  +FIY+MPG+T S++ERMLYSSCK+P L+++++   + I RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    2 THRWGYRVKISSEDVLEMFARARNGKYRLLKLDIEDEQLTVTACEKPASSWEQEYDSLILPLLEDKQPCYIMYRLDSQNAQGFEWIFIAWSPDHSHVRQKMLYAATRATVKKEFGGGHIKEELFGTVKDDISLKGYYKYLACQSSPAPLTMAEEELRQIKIKETQVDIGVDTKHQTLQGIAFPIEKAAFQALEQLREKRLNYVQLKIDIKNETIILADTTNTEVR--DLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMPGYTCSIRERMLYSSCKSPLLDVIENRLLMEIARKIEIDNGD--ELTPDFLYEEVHPKQ 319

[Close]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Match: dcdc2b (doublecortin domain containing 2B [Source:Xenbase;Acc:XB-GENE-5892141])

HSP 1 Score: 220.32 bits (560), Expect = 3.992e-68
Identity = 109/301 (36.21%), Postives = 185/301 (61.46%), Query Frame = 2

Query:  116 SKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            ++  K R +++ IE+E L +   +K   ++E +YD  I   L+  Q CYI+YR D+    G EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  E++ G  K D+   GY KY   +S+P PLT+AE+EL +IK  E +  +G     +TL+   FP      + L +     ++++++ I+I  ET I  D++ +E+    L   +  D  RY+ + ++H+ E +  +  +FIY+MPG+T S++ERMLYSSCK+P L+++++   + I RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    5 ARNGKYRLLKLDIEDEQLTVTACEKPASSWEQEYDSLILPLLEDKQPCYIMYRLDSQNAQGFEWIFIAWSPDHSHVRQKMLYAATRATVKKEFGGGHIKEELFGTVKDDISLKGYYKYLACQSSPAPLTMAEEELRQIKIKETQVDIGVDTKHQTLQGIAFPIEKAAFQALEQLREKRLNYVQLKIDIKNETIILADTTNTEVR--DLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMPGYTCSIRERMLYSSCKSPLLDVIENRLLMEIARKIEIDNGD--ELTPDFLYEEVHPKQ 301

[Close]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Match: dcdc2b (doublecortin domain containing 2B [Source:Xenbase;Acc:XB-GENE-5892141])

HSP 1 Score: 219.935 bits (559), Expect = 5.708e-68
Identity = 109/301 (36.21%), Postives = 185/301 (61.46%), Query Frame = 2

Query:  116 SKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            ++  K R +++ IE+E L +   +K   ++E +YD  I   L+  Q CYI+YR D+    G EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  E++ G  K D+   GY KY   +S+P PLT+AE+EL +IK  E +  +G     +TL+   FP      + L +     ++++++ I+I  ET I  D++ +E+    L   +  D  RY+ + ++H+ E +  +  +FIY+MPG+T S++ERMLYSSCK+P L+++++   + I RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    5 ARNGKYRLLKLDIEDEQLTVTACEKPASSWEQEYDSLILPLLEDKQPCYIMYRLDSQNAQGFEWIFIAWSPDHSHVRQKMLYAATRATVKKEFGGGHIKEELFGTVKDDISLKGYYKYLACQSSPAPLTMAEEELRQIKIKETQVDIGVDTKHQTLQGIAFPIEKAAFQALEQLREKRLNYVQLKIDIKNETIILADTTNTEVR--DLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMPGYTCSIRERMLYSSCKSPLLDVIENRLLMEIARKIEIDNGD--ELTPDFLYEEVHPKQ 301

[Close]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Match: Twf1 (twinfilin actin binding protein 1 [Source:MGI Symbol;Acc:MGI:1100520])

HSP 1 Score: 243.047 bits (619), Expect = 1.042e-76
Identity = 119/320 (37.19%), Postives = 205/320 (64.06%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ +      ++E DYD  +   L+  Q CY+L+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T  ++    +TL+   FP + +  + L K S  +++++++ I+I  ET I  ++  +EL    L   +  D  RY+ + ++H+ E +  E ++FIY+MPG+T S++ERMLYSSCK+P LE+++ + Q+++ RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELR--DLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGD--ELTADFLYDEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Match: Twf2 (twinfilin actin binding protein 2 [Source:MGI Symbol;Acc:MGI:1346078])

HSP 1 Score: 235.343 bits (599), Expect = 1.060e-73
Identity = 117/319 (36.68%), Postives = 196/319 (61.44%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M H +GI ++ +L +    ++   IR I+V IE+E LV+    +  G ++ DYDR +   L   + CY+L+R D+    G EWLFL W PDN+ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL  +GY K+  S +AP PLT AE+EL +I+ NE +T +      +TL+   FP        L +     ++++++ +++++ETI+   ++   +   L S +  D  RY+ + ++HT E ++ E ++FIY+MPG+  S+KERMLYSSCK+  L+ ++ +FQL I +K+E+  GD ++L  + L  ++HP Q
Sbjct:    1 MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEP-TNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEI--GDGAELTAEFLYDEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Match: Twf2 (twinfilin actin binding protein 2 [Source:MGI Symbol;Acc:MGI:1346078])

HSP 1 Score: 226.868 bits (577), Expect = 1.773e-70
Identity = 112/300 (37.33%), Postives = 186/300 (62.00%), Query Frame = 2

Query:  116 SKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            ++   IR I+V IE+E LV+    +  G ++ DYDR +   L   + CY+L+R D+    G EWLFL W PDN+ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL  +GY K+  S +AP PLT AE+EL +I+ NE +T +      +TL+   FP        L +     ++++++ +++++ETI+   ++   +   L S +  D  RY+ + ++HT E ++ E ++FIY+MPG+  S+KERMLYSSCK+  L+ ++ +FQL I +K+E+  GD ++L  + L  ++HP Q
Sbjct:   18 ARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPT-NVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEI--GDGAELTAEFLYDEVHPKQ 314

[Close]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Match: Twf2 (twinfilin actin binding protein 2 [Source:MGI Symbol;Acc:MGI:1346078])

HSP 1 Score: 145.591 bits (366), Expect = 4.495e-41
Identity = 76/239 (31.80%), Postives = 125/239 (52.30%), Query Frame = 2

Query:  167 LVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCK 883
            LV+    +  G ++ DYDR +   L   + CY+L+R D+    G EWLFL W PDN+ +R KMLYA+TR+T+K+EFG         GH K                          EL    + + E ++    +TL+   FP        L +     ++++++ +++++ETI+   ++   +   L S +  D  RY+ + ++HT E ++ E ++FIY+MPG+  S+KERMLYSSCK
Sbjct:    3 LVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFG--------GGHIK-------------------------DELFGTVKVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPT-NVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCK 207

[Close]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Match: Twf2 (twinfilin actin binding protein 2 [Source:MGI Symbol;Acc:MGI:1346078])

HSP 1 Score: 142.124 bits (357), Expect = 2.128e-39
Identity = 79/268 (29.48%), Postives = 136/268 (50.75%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVK 856
            M H +GI ++ +L +    ++   IR I+V IE+E LV+    +  G ++ DYDR +   L   + CY+L+R D+    G EWLFL W PDN+                                  DL  +GY K+  S +AP PLT AE+EL +I+ NE +T +      +TL+   FP        L +     ++++++ +++++ETI+   ++   +   L S +  D  RY+ + ++HT E ++ E ++FIY+MPG+  S+K
Sbjct:    1 MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSP--------------------------------DDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPT-NVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIK 235

[Close]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Match: sp|Q5R7N2|TWF1_PONAB (Twinfilin-1 OS=Pongo abelii OX=9601 GN=TWF1 PE=2 SV=1)

HSP 1 Score: 246.128 bits (627), Expect = 3.991e-77
Identity = 120/320 (37.50%), Postives = 206/320 (64.38%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ ++ +   +++ DYD  +   L+  Q CYIL+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T +G     +TL+   FP +    + L K +N +++++++ I+I  E  I  +++ +EL    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG+T S++ERMLYSSCK+P LE+++ + Q+ + RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHRTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTDTELK--DLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMGVIRKIEIDNGD--ELTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Match: sp|Q56JV6|TWF1_BOVIN (Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=1)

HSP 1 Score: 243.432 bits (620), Expect = 4.351e-76
Identity = 121/320 (37.81%), Postives = 205/320 (64.06%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + D    ++  K R +++ IENE LV+ +  K   +++ DYD  +   L+  Q CY+L+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T  ++    +TL+   FP +    + L K +N +++++++ I+I  E  I  ++  +EL    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG+T S++ERMLYSSCK+P LE+++ + Q++I RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELK--DLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGD--ELTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Match: sp|Q12792|TWF1_HUMAN (Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3)

HSP 1 Score: 243.432 bits (620), Expect = 5.168e-76
Identity = 119/320 (37.19%), Postives = 206/320 (64.38%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKE-TIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ ++ +   +++ DYD  +   L+  Q CYIL+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T +G     +TL+   FP +    + L K +N +++++++ I+I  E  I  +++ +EL    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG+T S++ERMLYSSCK+  LE+++ + Q+++ RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELK--DLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGD--ELTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Match: sp|Q91YR1|TWF1_MOUSE (Twinfilin-1 OS=Mus musculus OX=10090 GN=Twf1 PE=1 SV=2)

HSP 1 Score: 243.047 bits (619), Expect = 7.291e-76
Identity = 119/320 (37.19%), Postives = 205/320 (64.06%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKET-IKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S  + +    ++  K R +++ IENE LV+ +      ++E DYD  +   L+  Q CY+L+R D+    G+EW+F+ W PD++ +R+KMLYA+TR+T+K+EFG  +  +++ G  K D+   GY KY  S+S+P PLT AE+EL +IK NE +T  ++    +TL+   FP + +  + L K S  +++++++ I+I  ET I  ++  +EL    L   +  D  RY+ + ++H+ E +  E ++FIY+MPG+T S++ERMLYSSCK+P LE+++ + Q+++ RK+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELR--DLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGD--ELTADFLYDEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Match: sp|Q298X4|TWF_DROPS (Twinfilin OS=Drosophila pseudoobscura pseudoobscura OX=46245 GN=twf PE=3 SV=2)

HSP 1 Score: 240.736 bits (613), Expect = 3.911e-75
Identity = 123/324 (37.96%), Postives = 194/324 (59.88%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGF--PPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKP 1024
            M+H +GIR++ +L   +  +K  K+R ++V IENE L  +     + ++E DYD+ +   L+    CYILYR D    LGH WL + W+PD ASIR+KM+YAST++T+K EFG +Y  E++      +    GY K++   +AP PLT  E+EL E+++ E  T +    R     G   P TD  +  +     G  D+L+  I++++E I + S  +++   +L   V  D  RY+L+ FRHT E +  E  +F+Y+MPG+T SV+ERM+YSSCKAPFLE L +   +++ +KLE+ +G+  +L    LL ++HP +I  +P
Sbjct:    1 MSHQTGIRANEQLAKVLGKAKNGKLRVVKVSIENEQLSCSATADVKKDWERDYDKLLGPLLEETVPCYILYRLDAKIPLGHSWLLISWIPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLEETTLEGYRKHKRDFAAPAPLTTREEELKELRKTEVHTEISTNTRHQTLGGISCPLTDATVAAVQDLVRGNYDYLQFRIDLEEERI-HVSHAAQVELSALPKQVPEDHARYHLFLFRHTHEGDYQESYVFVYSMPGYTCSVRERMMYSSCKAPFLEQLAA-LGVDVVKKLEIDNGN--ELTEAYLLDELHPKKILHRP 320

[Close]

BLAST of Twinfilin-1 vs. TrEMBL
Match: A0A4W4GZX1 (Uncharacterized protein OS=Electrophorus electricus OX=8005 GN=TWF1 (1 of many) PE=4 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 6.428e-78
Identity = 125/320 (39.06%), Postives = 212/320 (66.25%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIK-NDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S ++ D    ++    R +++ IE+E LV+ +  +A  ++E DY+  I   L+ +  CY+LYR D++  +GHEW+F+ W PD++ +R KMLYA+TR+T+K+EFG  +  ++I G  K D+  SGY +Y  S+SAP PLT AE+EL +IK +E +T +G    Q+TL+   FP   + +E L KF + ++ ++++ I+ +KE I  +++  +E+    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG++ S+KERMLYSSCK P L+ML+S+ Q++I++K+E+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQASRQVKDVFANARNGDYRVLKIVIEDEELVLGDTKQASRSWEEDYNSLILPLLENNLPCYVLYRLDSTNSMGHEWVFIAWSPDHSPVRHKMLYAATRATLKKEFGGGHIKDEIFGTVKDDVSLSGYKRYITSQSAPLPLTAAEEELRQIKLSEVQTDIGVDTKQQTLQGVAFPLHGDAMEALQKFKDRKLSYVQLKIDFEKERIMLSNTDPAEIR--DLPKRIPKDAARYHFFLYKHSHEGDHLESIVFIYSMPGYSCSIKERMLYSSCKNPLLDMLESKLQMDIEKKIEIDNGD--ELTADYLYNEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. TrEMBL
Match: A0A3B4CL22 (Twinfilin actin-binding protein 1a OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 4.339e-77
Identity = 123/320 (38.44%), Postives = 210/320 (65.62%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIK-NDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI+++ ++ D    ++    R +++ IE+E LV+ +  +A  ++E DY+  +   L  D  CYILYR D++   GHEW+F+ W PD++ +R KMLYA+TR+T+K+EFG  +  ++I G  K D+  +GY K+  S+SAP PLT AE+EL +IK +E +T  ++   Q+TL+   FP   + +E L KF +   +++++ I+ DKE I  +++ ++E+    L   +  D  RY+ + ++H+ E +  E I+FIY+MPG++ S+KERMLYSSCK+P ++M++S+ Q+ I++KLE+ +GD  +L  D L  ++HP Q
Sbjct:    1 MSHQTGIQAAGEVKDIFARARNGDYRALKIVIEDEKLVLGDTKRASRSWEEDYNSLVLPLLDNDLPCYILYRLDSTNSFGHEWVFIAWSPDHSPVRHKMLYAATRATVKKEFGGGHIKDEIFGTVKDDISLNGYKKHITSQSAPLPLTAAEEELRQIKLSEVQTDISVDTKQQTLQGVAFPLHGDAMEALQKFRDKTFNYVQLKIDFDKELIMLSNTDRTEVR--DLPKRIPKDAARYHFFLYKHSHEGDHLESIVFIYSMPGYSCSIKERMLYSSCKSPLIDMVESKLQMEIEKKLEIDNGD--ELTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. TrEMBL
Match: D6X1X0 (Twinfilin-like Protein OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC012105 PE=4 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 4.383e-77
Identity = 130/325 (40.00%), Postives = 206/325 (63.38%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPK 1027
            M+H +GI+++ +L   +   ++ K+R +++ IENE L +A+H + + +++ D+D CI   ++ +Q CY+LYR D+    G+EWLF+ W PD A +R+KMLYAST++T+K+EFG S   E++ G    D+  +GY K++++ SAP PLT  E+EL EI+R    T  ++   Q+TL    FP T+   + +   + G  D+L+  I I++ETI +  +  +LS + L S V  D  RY+LY+F+HT E +  E I+FIY+MPG+   +KERMLYSSCK P  + + S   L I +KLE+ SG  S+L  + L  +IHP +   +PK
Sbjct:    1 MSHQTGIKANDELKKFLGKCRDGKVRIVKISIENEQLTLASHKEVKHSWDKDFDACITPLIEENQPCYLLYRLDSKNSSGYEWLFISWSPDTAPVRQKMLYASTKATLKQEFGTSQIKEELHGTVTSDITLNGYQKHKKAVSAPAPLTTREEELQEIRRTVVHTDISVDSKQQTLSGVAFPLTEAARQAVVDMARGSYDYLQFKINIEEETI-HLVTAEKLSIEKLPSKVPADSGRYHLYKFKHTHEGDYMENIVFIYSMPGYNCPIKERMLYSSCKNPLTDTITS-LGLEIVKKLEIDSG--SELTEEFLYEEIHPTKNLHRPK 321

[Close]

BLAST of Twinfilin-1 vs. TrEMBL
Match: A0A1W4XN17 (twinfilin isoform X1 OS=Agrilus planipennis OX=224129 GN=LOC108742914 PE=4 SV=1)

HSP 1 Score: 251.906 bits (642), Expect = 5.342e-77
Identity = 131/327 (40.06%), Postives = 202/327 (61.77%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPKIT 1033
            M+H +GI ++  L       K+ K+R  +V IENE LV+++H   + N+E DYD+ +   ++ +Q CYILYR D     G+EWLF+ W PD A++R+KMLYAST++T+K+EFG S   E+I G  K ++   GY KY++  +AP PL++ E+EL E+KR E  T  ++    +TL    FP T+   + +     G  D+L+  I+I+ E I N ++   +  + L S V     RY+LYRF HT E +  E I+FIY+MPG++ S+KERMLYSSCK P ++++ ++  L+I +KLE+ SG  S+L    L  +IHP +   +P+  
Sbjct:    1 MSHQTGIHANDALKKFFVKCKDGKVRVFKVSIENEQLVLSSHHAIKHNWEKDYDKYVLPLIEENQPCYILYRLDTKNDSGYEWLFISWSPDTATVRQKMLYASTKATLKQEFGSSQIKEEIHGTIKSEITLDGYKKYKKVLAAPAPLSMREEELNEVKRTEVHTDISINSKHQTLGGVAFPVTEPAQQAIIDMKRGSYDYLQFEIDIENEKI-NLATAENVPIEKLPSKVPEKSARYHLYRFMHTHEGDYMESIVFIYSMPGYSCSIKERMLYSSCKNPLIDVI-TQLGLDINKKLEIDSG--SELTESFLYEEIHPTKNLHRPQFA 323

[Close]

BLAST of Twinfilin-1 vs. TrEMBL
Match: W5L5D2 (Twinfilin actin-binding protein 1a OS=Astyanax mexicanus OX=7994 PE=4 SV=2)

HSP 1 Score: 251.521 bits (641), Expect = 1.105e-76
Identity = 125/320 (39.06%), Postives = 208/320 (65.00%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELS-CDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S ++ D    ++    R +++ IE+E LV+ +  KA   +E DY+  +   L+ D  CYILYR D++  LGHEW+F+ W PD++ +R KMLYA+TR+T+K+EFG     +++ G  K D+  +GY K+  S+SAP PLT AE+EL +IK +E +T  ++   Q+TL+   FP   + +E L KF + + +++++ I+ DKE I    S ++L+    L   +  D  RY+ + ++H+ E +  + I+FIY+MPG+  S+KERMLYSSCK+P ++M++++ Q+ I++KLE+ +GD  DL  D L  ++HP Q
Sbjct:    1 MSHQTGIQASREVKDIFASARNGDFRVLKIVIEDEQLVLGDTRKASRGWEEDYNTLVLPLLENDLPCYILYRLDSTNSLGHEWVFVAWSPDHSPVRHKMLYAATRATVKKEFGGGLIKDEVFGTVKDDVSLNGYKKHLCSQSAPVPLTAAEEELRQIKLSEVKTDISVDTKQQTLQGVAFPLHGDAMEALEKFRDKKFNYVQLKIDFDKELIM--LSNTDLTEVRDLPKRIPKDAARYHFFLYKHSHEGDQLQSIVFIYSMPGYNCSIKERMLYSSCKSPLIDMVENKLQMEIEKKLEIDNGD--DLTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Match: twf1a (twinfilin-1-like [Source:NCBI gene;Acc:103047464])

HSP 1 Score: 251.521 bits (641), Expect = 4.187e-80
Identity = 125/320 (39.06%), Postives = 208/320 (65.00%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELS-CDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++S ++ D    ++    R +++ IE+E LV+ +  KA   +E DY+  +   L+ D  CYILYR D++  LGHEW+F+ W PD++ +R KMLYA+TR+T+K+EFG     +++ G  K D+  +GY K+  S+SAP PLT AE+EL +IK +E +T  ++   Q+TL+   FP   + +E L KF + + +++++ I+ DKE I    S ++L+    L   +  D  RY+ + ++H+ E +  + I+FIY+MPG+  S+KERMLYSSCK+P ++M++++ Q+ I++KLE+ +GD  DL  D L  ++HP Q
Sbjct:    1 MSHQTGIQASREVKDIFASARNGDFRVLKIVIEDEQLVLGDTRKASRGWEEDYNTLVLPLLENDLPCYILYRLDSTNSLGHEWVFVAWSPDHSPVRHKMLYAATRATVKKEFGGGLIKDEVFGTVKDDVSLNGYKKHLCSQSAPVPLTAAEEELRQIKLSEVKTDISVDTKQQTLQGVAFPLHGDAMEALEKFRDKKFNYVQLKIDFDKELIM--LSNTDLTEVRDLPKRIPKDAARYHFFLYKHSHEGDQLQSIVFIYSMPGYNCSIKERMLYSSCKSPLIDMVENKLQMEIEKKLEIDNGD--DLTADFLYEEVHPKQ 316

[Close]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Match: twf1b (twinfilin actin-binding protein 1b [Source:ZFIN;Acc:ZDB-GENE-040711-3])

HSP 1 Score: 228.024 bits (580), Expect = 3.356e-71
Identity = 113/319 (35.42%), Postives = 193/319 (60.50%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI+++ ++ D    ++  + R I+V IENE LV+     A   ++ ++D  +   LQ D   Y+LYR D +   G+EW+FL W PD++ +R+KMLYA+TR+T+K+EFG  +  E+I G  K D+  +GY +Y  S++AP PLT AE+EL +IK +E +T   +   Q+TL+   FP   + I+ L +F    ++++++ I+   E+IK                +  D  RY+ + ++HT E +  E  +FIY+MPG+  S++ERMLYSSCK P ++ ++   ++ + +KLE+ +GD  +L +D +  ++HP Q
Sbjct:    1 MSHQTGIQATAEVKDIFAKARNGEYRLIKVVIENEQLVLGGTKPAAKKWDQEWDSYVLPLLQDDLPSYLLYRLDTTNNQGYEWIFLAWSPDHSPVRQKMLYAATRATLKKEFGGGHIKEEIFGTAKDDVSLNGYKRYLTSQAAPLPLTAAEEELRQIKLSEVQTDIHIDTKQQTLQGVAFPMQRDAIQALEQFREKRVNYVQLEIDFPNESIK---------------LIPKDAARYHFFLYKHTHEGDYLESTVFIYSMPGYKCSIRERMLYSSCKNPLIDTVEKNLRIEVAKKLEIDNGD--ELTSDYMYEEVHPKQ 302

[Close]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Match: twf2a (twinfilin-2 [Source:NCBI gene;Acc:103022587])

HSP 1 Score: 217.238 bits (552), Expect = 8.007e-67
Identity = 112/299 (37.46%), Postives = 178/299 (59.53%), Query Frame = 2

Query:  134 RCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNE-------RETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            R IQV I NE LV+  + +   ++E DYD  +   L P + CYILYR D+    G+EWLF+ W PD + +R+KMLYA+TR+T+K+EFG  +  +++ G+ + D+   GYL++  S S P PLT AEQEL  IK  E        E  +    +T++   FP        L +     I+++++ ++ +KETI+   ++   + D L   V  D PRY+ + ++H  E    E ++FIY+MPG++ SVKERMLYSSCK+  L+ ++ ++ + + +KLE+ SGD  +L  + L  ++HP Q
Sbjct:   24 RLIQVLIRNEQLVLGAYREPSQSWEKDYDNFLLPLLDPQEPCYILYRLDSQNAQGYEWLFISWSPDQSPVRQKMLYAATRATVKKEFGGGHVKDELFGNVEDDVSLQGYLRHVSSSSGPAPLTAAEQELQRIKITEGMVKQVKTEINVETKHQTVQGLAFPLQAEAKRALQQLKERRINYIQLRLDTEKETIELVHTRPTETHD-LPCRVPTDTPRYHFFLYKHAHEGAYMESVVFIYSMPGYSCSVKERMLYSSCKSRLLDEVERDYHIEVVKKLEIDSGD--ELTEEYLYDEVHPKQ 319

[Close]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Match: twf2b (twinfilin-2-like [Source:NCBI gene;Acc:103023282])

HSP 1 Score: 217.624 bits (553), Expect = 8.524e-67
Identity = 113/348 (32.47%), Postives = 202/348 (58.05%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERE-------TALGDGQ---------RTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIK----NDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHP-----PQIDSKPK 1027
            M+H +GI ++  L + +  ++   +R +++ I +E LV+  + +   +++ DYD C+   L   + CYIL+R D+  + G+EWLF+ W PD   +R KM+YA+TR+T+K+EFG S+  +++ G  + D+ + GYL++  S S+P PLT AEQEL ++K  E E       +  G G+          T++   FP  + +   L +     I+++++ ++ ++ETI+    N +   EL      + +  D PRY+ + ++H+ + +S E ++FIY+MPG+  S+K+RMLYSSCK   LE ++ ++ + I +K+E+ SG+   L  + L  +IHP      Q  +KPK
Sbjct:    1 MSHQTGIHATADLREFLVTARRGAVRVMKIVIRSEQLVLGAYRELAQSWDRDYDPCVLPLLDSLEPCYILFRLDSQNQQGYEWLFISWSPDQCLVRLKMVYAATRATLKKEFGGSHIKDELFGTTQEDVCFQGYLRHLSSCSSPAPLTSAEQELHQLKATEEERRRVAAPSGKGKGKTEISVESKHSTVQGLAFPLQEGVKRALEQLKQRRINYIQLRLDTERETIELVHTNPTETRELP-----ARIPADAPRYHFFLYKHSHQGQSVEAVVFIYSMPGYICSIKDRMLYSSCKNRLLEEVERDYHIEINKKMEIDSGE--SLTEEYLYEEIHPKPQALKQAFTKPK 341

[Close]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Match: twf2b (twinfilin-2-like [Source:NCBI gene;Acc:103023282])

HSP 1 Score: 202.601 bits (514), Expect = 1.393e-61
Identity = 104/300 (34.67%), Postives = 180/300 (60.00%), Query Frame = 2

Query:  161 ESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALG--DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIK----NDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHP-----PQIDSKPK 1027
            E LV+  + +   +++ DYD C+   L   + CYIL+R D+  + G+EWLF+ W PD   +R KM+YA+TR+T+K+EFG S+  +++ G  + D+ + GYL++  S S+P PLT AEQEL ++K  E +T +       T++   FP  + +   L +     I+++++ ++ ++ETI+    N +   EL      + +  D PRY+ + ++H+ + +S E ++FIY+MPG+  S+K+RMLYSSCK   LE ++ ++ + I +K+E+ SG+   L  + L  +IHP      Q  +KPK
Sbjct:    9 EQLVLGAYRELAQSWDRDYDPCVLPLLDSLEPCYILFRLDSQNQQGYEWLFISWSPDQCLVRLKMVYAATRATLKKEFGGSHIKDELFGTTQEDVCFQGYLRHLSSCSSPAPLTSAEQELHQLKATEGKTEISVESKHSTVQGLAFPLQEGVKRALEQLKQRRINYIQLRLDTERETIELVHTNPTETRELP-----ARIPADAPRYHFFLYKHSHQGQSVEAVVFIYSMPGYICSIKDRMLYSSCKNRLLEEVERDYHIEINKKMEIDSGE--SLTEEYLYEEIHPKPQALKQAFTKPK 301

[Close]

BLAST of Twinfilin-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007240.1 (pep scaffold:Pmarinus_7.0:GL476479:38272:39885:-1 gene:ENSPMAG00000006535.1 transcript:ENSPMAT00000007240.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.1358 bits (113), Expect = 4.710e-7
Identity = 23/58 (39.66%), Postives = 36/58 (62.07%), Query Frame = 2

Query:  233 KYLQPDQCCYILY----RTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREF 394
            K L P+ C Y LY     T+ S K   + +F+ W PD+A ++ KM+YAS++  IK++F
Sbjct:   73 KLLPPNDCRYALYDATYETNESKK--EDLVFVFWAPDSAPLKSKMIYASSKDAIKKKF 128

[Close]

BLAST of Twinfilin-1 vs. Ensembl Sea Lamprey
Match: cfl1 (cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215])

HSP 1 Score: 45.8246 bits (107), Expect = 2.804e-6
Identity = 23/62 (37.10%), Postives = 35/62 (56.45%), Query Frame = 2

Query:  215 YDRCIEKYLQPDQCCYILYRTDNSTK--LGHEWLFLHWVPDNASIREKMLYASTRSTIKREF 394
            YD  + K L  D C Y LY     T+     + +F+ W PD A ++ KM+YAS++  IK++F
Sbjct:   68 YDTFV-KLLPKDDCRYALYDATYETRETKKEDLVFIFWAPDGAPLKSKMVYASSKEAIKKKF 128

[Close]

BLAST of Twinfilin-1 vs. Ensembl Yeast
Match: TWF1 (Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1 [Source:SGD;Acc:S000003312])

HSP 1 Score: 62.3882 bits (150), Expect = 2.701e-11
Identity = 68/261 (26.05%), Postives = 123/261 (47.13%), Query Frame = 2

Query:  215 YDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGE-SYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNE----RETALG----DGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDL 970
            ++  ++   Q  +  YI Y+ +   K    + F+ ++PD + +R +MLYAST++T+ R+ G  S   E     D  DL+               PLT  E+  IEI + +    + T++     D    L  +    ++  I E+   S G+ + +   I+   ETI+   S +  S D L   ++   P Y ++R     + +S     FIY+ P   S VK+RM+Y+S K  F+  L+++ ++   + +E+  GDF +L
Sbjct:   49 FEELVQLASQEREPLYIFYKPEGLDK----YFFVSFIPDGSPVRSRMLYASTKNTLARQVGSNSLSTEQPLITDAQDLVDLKNFDSARPAGQNKPLTHDEEMQIEINKQQALLRKNTSVKLVSQDSASPLSLTFRVNSEKPINEILD-SEGK-NLIIFQIDPSNETIQIVQSDTCPSVDELY--IDLPGPSYTIFR-----QGDSS---FFIYSCPS-GSKVKDRMIYASNKNGFINYLKNDQKIAFSKVVEI--GDFVEL 290

[Close]

BLAST of Twinfilin-1 vs. Ensembl Nematostella
Match: EDO45331 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT59])

HSP 1 Score: 247.284 bits (630), Expect = 6.873e-79
Identity = 122/328 (37.20%), Postives = 199/328 (60.67%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNE---RETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPKIT 1033
            M+H +GI++S  L      SK+  IR I+V IENE L+     + + ++E DYD  + ++L+  Q CYILYR D+    G+EWLF+ + PD + IR+KML+A TR+T+K+EFG  +  +++ G +  D+   GY  +  S  APPPLT  E EL  +K+ E    E ++   Q  +    FPPT+  + EL K  +G++ ++++ ++++KE I    S+  +  D L+ +V  D  RY+ Y F+HT+E +  E I+FIY+MPG+   +KERMLYSSCK P + + + + ++ I +K+E+   D S+L  D L+ ++HP +   +PK  
Sbjct:    1 MSHQTGIQASEDLKSVFARSKDGDIRMIKVGIENEELICITTTEPKKDWERDYDDAVVRHLEEKQPCYILYRLDSKNNQGYEWLFIAYSPDFSPIRQKMLFAGTRATLKKEFGGGHIKDELFGTNVADVCLDGYHSHMTSAKAPPPLTNEEAELELVKKEEGVRTEISISTKQSHMTGVHFPPTEEAVAELEKMRSGDVGYIQLKLDLEKEIINLVKSEFHIEADDLKGHVPSDSARYHFYLFKHTYEGDYQESIVFIYSMPGYNCPIKERMLYSSCKGPLVSLAEDDLKMVIVKKIEI--SDASELCEDFLMGEVHPIKNVHRPKFA 326

[Close]

BLAST of Twinfilin-1 vs. Ensembl Nematostella
Match: EDO38186 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDL8])

HSP 1 Score: 44.669 bits (104), Expect = 9.234e-6
Identity = 28/82 (34.15%), Postives = 46/82 (56.10%), Query Frame = 2

Query:  215 YDRCIEKYLQPDQCCYILYRTDNSTKLG---HEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMY 451
            +D+ +EK L   +  YILY  +   K G   H  +++ W  DNA I+++M+ A+T   +KR+FG     +D   +D+ DL Y
Sbjct:   61 FDQMLEK-LSDSEPRYILYDLNFPRKDGRAFHHLVYIFWSSDNAPIKKRMVSAATNELLKRKFG---VKKDFQINDRADLSY 138

[Close]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Match: twf1a (twinfilin actin binding protein 1 [Source:NCBI gene;Acc:101158191])

HSP 1 Score: 225.713 bits (574), Expect = 3.990e-70
Identity = 115/320 (35.94%), Postives = 196/320 (61.25%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKE-NKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++  ++ +    ++  ++ R +++ IE+E L +    KA   ++ +YD  +   L  D  CYILYR D++   G EW+ L W PD++ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL  SGY KY  S+SAP PLT AE+EL +IK +E +T  ++   Q+TL+   FP   +  E L +F   +I+++++ I  ++E I +  +        L   +  D PRY+ + ++H+ E +  E  +FIY+MPG+  S++ERMLYSSCK   ++M+++  Q+ I++KLE+  G+  +L +D L  ++HP Q
Sbjct:    1 MSHQTGIQAGNEVKNIFACARSGDEYRALKIVIEDEQLSLGTTRKASKKWDQEYDSLVLPLLDDDMPCYILYRLDSTNNQGFEWILLAWSPDHSMVRHKMLYAATRATLKKEFGGGHIKDELFGTAKEDLNLSGYRKYLTSQSAPLPLTAAEEELRQIKLSEVQTDISVDTKQQTLQGVAFPIGKDAAEALKRFREKKINYVQLQINAEREMI-HLCNTEPTEVKDLPKRIPKDSPRYHFFLYKHSHEGDYLESTVFIYSMPGYKCSIRERMLYSSCKNNLIDMVENNLQIEIEKKLEIEGGE--ELTSDFLYEEVHPKQ 317

[Close]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Match: twf1a (twinfilin actin binding protein 1 [Source:NCBI gene;Acc:101158191])

HSP 1 Score: 225.328 bits (573), Expect = 5.027e-70
Identity = 115/320 (35.94%), Postives = 196/320 (61.25%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKE-NKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERET--ALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQ 1009
            M+H +GI++  ++ +    ++  ++ R +++ IE+E L +    KA   ++ +YD  +   L  D  CYILYR D++   G EW+ L W PD++ +R KMLYA+TR+T+K+EFG  +  +++ G  K DL  SGY KY  S+SAP PLT AE+EL +IK +E +T  ++   Q+TL+   FP   +  E L +F   +I+++++ I  ++E I +  +        L   +  D PRY+ + ++H+ E +  E  +FIY+MPG+  S++ERMLYSSCK   ++M+++  Q+ I++KLE+  G+  +L +D L  ++HP Q
Sbjct:    1 MSHQTGIQAGNEVKNIFACARSGDEYRALKIVIEDEQLSLGTTRKASKKWDQEYDSLVLPLLDDDMPCYILYRLDSTNNQGFEWILLAWSPDHSMVRHKMLYAATRATLKKEFGGGHIKDELFGTAKEDLNLSGYRKYLTSQSAPLPLTAAEEELRQIKLSEVQTDISVDTKQQTLQGVAFPIGKDAAEALKRFREKKINYVQLQINAEREMI-HLCNTEPTEVKDLPKRIPKDSPRYHFFLYKHSHEGDYLESTVFIYSMPGYKCSIRERMLYSSCKNNLIDMVENNLQIEIEKKLEIEGGE--ELTSDFLYEEVHPKQ 317

[Close]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Match: ENSORLT00000023458.2 (twinfilin-2 [Source:NCBI gene;Acc:110014671])

HSP 1 Score: 220.32 bits (560), Expect = 4.183e-68
Identity = 115/322 (35.71%), Postives = 195/322 (60.56%), Query Frame = 2

Query:   83 SSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQR--TLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHP-----PQIDSKPK 1027
            ++ +L D +  ++   IR +++ I NE LV+ +  +   ++E DYD+ +   L P Q CYILYR D+    G+EW+F+ W PD++ +R+KM+YA+TR+T+K+EFG  +  +++ G  + DL   GYL+++ S S+P PLT AEQEL  I+  E     G  +R  TL+   FP  D     L +     I+++++ ++++KETI+   +K       L   +  D PRY+ + F+H+ + +  E ++FIY+MPG+  S+KERMLYSSCK   L+ ++ ++QL + +K+E+ SGD   L  + L  ++HP      Q+ +KP+
Sbjct:    7 ATSELKDFLAQARGGSIRIMKIIIRNEELVLDSCREPVHSWEKDYDQFLLPLLTPQQPCYILYRLDSKNSQGYEWIFISWSPDHSPVRQKMMYAATRATLKKEFGGGHIKDEMFGTVEDDLCLQGYLRHKSSCSSPAPLTAAEQELQRIRATEVTMEFGLDKRAQTLQGLSFPLQDEARRALQQLKLKRINYIQLRLDVEKETIELVHTKP-TEIHELPFRIPTDSPRYHFFVFKHSHQGQRDEALVFIYSMPGYMCSIKERMLYSSCKNRLLDEVERDYQLEVTKKMEIDSGD--GLTEEFLYEEVHPMEHTLKQVFAKPR 325

[Close]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Match: wdr82 (WD repeat domain 82 [Source:NCBI gene;Acc:110015105])

HSP 1 Score: 199.519 bits (506), Expect = 1.084e-57
Identity = 108/285 (37.89%), Postives = 167/285 (58.60%), Query Frame = 2

Query:  167 LVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSK 1021
            LV+  +   E +++ DYD  +   L   Q CYILYR D+   LG+EW+F+ W PD + +++KMLYA+TR+T+K+EFG  Y   ++ G  + D+   GY  +  S S P PLTLAEQEL +IK  E        +R L+               + S   I+++++ ++ +KETI+   S    + D L   V  D PRY+ + ++H+ E +  E I+FIY+MPG++ S+KERMLYSSCK+  LE ++ ++QL I +KLE+  GD  +L  + L  ++HP Q   K
Sbjct:  305 LVLGAYRDPEHSWDQDYDHFLLPLLDEQQPCYILYRLDSQNALGYEWIFISWSPDQSPVKQKMLYAATRATVKKEFGGGYVKYEMFGTTEEDICLQGYKHHVSSCSDPAPLTLAEQELKQIKITEVRGQHATAKRALQ---------------QLSLRHINYVQLRLDTEKETIELVHSNPTETRD-LPRRVPRDTPRYHFFLYKHSHEGDYLESIVFIYSMPGYSCSIKERMLYSSCKSRLLEEVEKDYQLEISKKLEIDDGD--ELTEEFLYDEVHPKQYAHK 571

[Close]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Match: cfl1 (cofilin 1 [Source:NCBI gene;Acc:101173715])

HSP 1 Score: 51.6026 bits (122), Expect = 1.649e-7
Identity = 24/56 (42.86%), Postives = 34/56 (60.71%), Query Frame = 2

Query:  233 KYLQPDQCCYILYRTDNSTK--LGHEWLFLHWVPDNASIREKMLYASTRSTIKREF 394
            K L PD C Y LY     TK     + +F+ W PD+A ++ KM+YAS++  IKR+F
Sbjct:   74 KMLPPDDCRYALYDATYETKETKKEDLVFIFWAPDSAPLKSKMIYASSKDAIKRKF 129

[Close]

BLAST of Twinfilin-1 vs. Planmine SMEST
Match: SMESG000041071.1 (SMESG000041071.1)

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 341/341 (100.00%), Postives = 341/341 (100.00%), Query Frame = 2

Query:   59 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPKITXXXXXXXXXXXXLMKD 1081
            MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPKITKPPGPSKRGPRRLMKD
Sbjct:    1 MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFETDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKMLYASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLAEQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLEMSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYEPIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGDFSDLVTDNLLLDIHPPQIDSKPKITKPPGPSKRGPRRLMKD 341

The following BLAST results are available for this feature:

BLAST of Twinfilin-1 vs. Ensembl Human
BLAST of Twinfilin-1 vs. Ensembl Celegans
BLAST of Twinfilin-1 vs. Ensembl Fly
BLAST of Twinfilin-1 vs. Ensembl Zebrafish
BLAST of Twinfilin-1 vs. Ensembl Xenopus
BLAST of Twinfilin-1 vs. Ensembl Mouse
BLAST of Twinfilin-1 vs. UniProt/SwissProt
BLAST of Twinfilin-1 vs. TrEMBL
BLAST of Twinfilin-1 vs. Ensembl Cavefish
BLAST of Twinfilin-1 vs. Ensembl Sea Lamprey
BLAST of Twinfilin-1 vs. Ensembl Yeast
BLAST of Twinfilin-1 vs. Ensembl Nematostella
BLAST of Twinfilin-1 vs. Ensembl Medaka
BLAST of Twinfilin-1 vs. Planmine SMEST

BLAST of Twinfilin-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TWF1	1.076e-76	37.19	twinfilin actin binding protein 1 [Source:HGNC Sym...	[more]
TWF2	1.635e-74	37.30	twinfilin actin binding protein 2 [Source:HGNC Sym...	[more]
TWF1	5.210e-74	35.78	twinfilin actin binding protein 1 [Source:HGNC Sym...	[more]
TWF2	1.541e-51	35.04	twinfilin actin binding protein 2 [Source:HGNC Sym...	[more]
TWF1	2.937e-48	33.46	twinfilin actin binding protein 1 [Source:HGNC Sym...	[more]

BLAST of Twinfilin-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
twf-2	8.819e-54	32.81	TWinFilin actin binding protein homolog [Source:U...	[more]
twf-2	8.819e-54	32.81	TWinFilin actin binding protein homolog [Source:U...	[more]

BLAST of Twinfilin-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
twf	1.555e-72	37.85	gene:FBgn0038206 transcript:FBtr0082891	[more]

BLAST of Twinfilin-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
twf1b	9.932e-74	36.36	twinfilin actin-binding protein 1b [Source:ZFIN;Ac...	[more]
twf2b	1.224e-69	34.20	twinfilin actin-binding protein 2b [Source:ZFIN;Ac...	[more]
twf2b	4.725e-69	34.00	twinfilin actin-binding protein 2b [Source:ZFIN;Ac...	[more]
twf2a	1.671e-63	37.76	twinfilin actin binding protein 2 [Source:NCBI gen...	[more]
twf2b	3.147e-62	32.75	twinfilin actin-binding protein 2b [Source:ZFIN;Ac...	[more]

BLAST of Twinfilin-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dcdc2b	2.362e-71	35.63	doublecortin domain containing 2B [Source:Xenbase;...	[more]
agxt2	5.354e-71	37.50	alanine--glyoxylate aminotransferase 2 [Source:Xen...	[more]
dcdc2b	3.845e-69	35.71	doublecortin domain containing 2B [Source:Xenbase;...	[more]
dcdc2b	3.992e-68	36.21	doublecortin domain containing 2B [Source:Xenbase;...	[more]
dcdc2b	5.708e-68	36.21	doublecortin domain containing 2B [Source:Xenbase;...	[more]

BLAST of Twinfilin-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Twf1	1.042e-76	37.19	twinfilin actin binding protein 1 [Source:MGI Symb...	[more]
Twf2	1.060e-73	36.68	twinfilin actin binding protein 2 [Source:MGI Symb...	[more]
Twf2	1.773e-70	37.33	twinfilin actin binding protein 2 [Source:MGI Symb...	[more]
Twf2	4.495e-41	31.80	twinfilin actin binding protein 2 [Source:MGI Symb...	[more]
Twf2	2.128e-39	29.48	twinfilin actin binding protein 2 [Source:MGI Symb...	[more]

BLAST of Twinfilin-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5R7N2\|TWF1_PONAB	3.991e-77	37.50	Twinfilin-1 OS=Pongo abelii OX=9601 GN=TWF1 PE=2 S...	[more]
sp\|Q56JV6\|TWF1_BOVIN	4.351e-76	37.81	Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=...	[more]
sp\|Q12792\|TWF1_HUMAN	5.168e-76	37.19	Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 S...	[more]
sp\|Q91YR1\|TWF1_MOUSE	7.291e-76	37.19	Twinfilin-1 OS=Mus musculus OX=10090 GN=Twf1 PE=1 ...	[more]
sp\|Q298X4\|TWF_DROPS	3.911e-75	37.96	Twinfilin OS=Drosophila pseudoobscura pseudoobscur...	[more]

BLAST of Twinfilin-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4W4GZX1	6.428e-78	39.06	Uncharacterized protein OS=Electrophorus electricu...	[more]
A0A3B4CL22	4.339e-77	38.44	Twinfilin actin-binding protein 1a OS=Pygocentrus ...	[more]
D6X1X0	4.383e-77	40.00	Twinfilin-like Protein OS=Tribolium castaneum OX=7...	[more]
A0A1W4XN17	5.342e-77	40.06	twinfilin isoform X1 OS=Agrilus planipennis OX=224...	[more]
W5L5D2	1.105e-76	39.06	Twinfilin actin-binding protein 1a OS=Astyanax mex...	[more]

BLAST of Twinfilin-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
twf1a	4.187e-80	39.06	twinfilin-1-like [Source:NCBI gene;Acc:103047464]	[more]
twf1b	3.356e-71	35.42	twinfilin actin-binding protein 1b [Source:ZFIN;Ac...	[more]
twf2a	8.007e-67	37.46	twinfilin-2 [Source:NCBI gene;Acc:103022587]	[more]
twf2b	8.524e-67	32.47	twinfilin-2-like [Source:NCBI gene;Acc:103023282]	[more]
twf2b	1.393e-61	34.67	twinfilin-2-like [Source:NCBI gene;Acc:103023282]	[more]

BLAST of Twinfilin-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000007240.1	4.710e-7	39.66	pep scaffold:Pmarinus_7.0:GL476479:38272:39885:-1 ...	[more]
cfl1	2.804e-6	37.10	cofilin 1 [Source:ZFIN;Acc:ZDB-GENE-030131-215]	[more]

BLAST of Twinfilin-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
TWF1	2.701e-11	26.05	Twinfilin; highly conserved actin monomer-sequeste...	[more]

BLAST of Twinfilin-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO45331	6.873e-79	37.20	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38186	9.234e-6	34.15	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Twinfilin-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
twf1a	3.990e-70	35.94	twinfilin actin binding protein 1 [Source:NCBI gen...	[more]
twf1a	5.027e-70	35.94	twinfilin actin binding protein 1 [Source:NCBI gen...	[more]
ENSORLT00000023458.2	4.183e-68	35.71	twinfilin-2 [Source:NCBI gene;Acc:110014671]	[more]
wdr82	1.084e-57	37.89	WD repeat domain 82 [Source:NCBI gene;Acc:11001510...	[more]
cfl1	1.649e-7	42.86	cofilin 1 [Source:NCBI gene;Acc:101173715]	[more]

BLAST of Twinfilin-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000041071.1	0.000e+0	100.00	SMESG000041071.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30015706 ID=SMED30015706|Name=Twinfilin-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1248bp
ATTTAATTGAGTATTTAAACTTTTTTTAAATCTCAAAAATCCCAGGAAGT
TTAATAAAATGACCCATGCAAGTGGTATACGATCATCAATTAAGCTAACG
GACGATATTAAATTTTCAAAAGAAAATAAAATTAGATGCATACAAGTAAA
AATTGAAAATGAATCATTGGTGATGGCGAATCACGACAAAGCCGAAGGAA
ATTTTGAGACAGATTATGATCGATGCATTGAAAAATATTTACAACCTGAT
CAATGTTGTTATATACTATATAGAACCGATAACTCCACTAAACTTGGACA
CGAATGGTTATTTCTTCATTGGGTTCCTGATAATGCATCCATCAGAGAAA
AAATGTTATATGCATCAACAAGATCGACAATTAAACGTGAATTTGGAGAA
AGCTATTTTGTTGAAGACATTACTGGTCACGATAAACCCGATTTAATGTA
CAGTGGTTATCTTAAATATCAAGAATCTAAATCAGCTCCACCGCCCCTCA
CTTTAGCAGAACAGGAATTAATTGAAATTAAACGAAATGAACGAGAAACG
GCTCTGGGAGATGGGCAGAGAACTCTCAAATGTTCTGGATTTCCTCCGAC
TGATAATTTAATAGAAGAGCTAACAAAATTTTCCAATGGAGAAATAGATT
TTCTTGAAATGAGCATTGAAATCGATAAGGAGACTATTAAAAATGATTCG
TCCAAGTCTGAATTAAGTTGTGATTCTTTGCGTAGCAATGTAAATCCAGA
TAAACCTCGCTATTATCTCTACAGGTTCAGGCATACCTTTGAGAATGAAT
CATATGAACCAATTATTTTCATTTACAATATGCCTGGATTTACATCTTCA
GTAAAAGAACGAATGCTTTATTCAAGCTGCAAAGCTCCGTTTTTAGAAAT
GTTGCAATCAGAATTTCAATTGAATATTCAAAGAAAACTTGAAGTCATAT
CTGGAGATTTCAGTGATCTTGTTACTGATAATCTTTTGTTAGATATTCAT
CCGCCACAAATCGATAGTAAGCCTAAAATAACGAAGCCACCCGGCCCAAG
TAAGCGTGGGCCTCGAAGACTAATGAAAGATTAATGTTTGCATTCCACTT
CAAATATTTAATGTGACTGATCTTCAAAATTTAATTTTGCTTAATTAGTA
TATGTTTCTGTTTTATGTTGTGTTATTGACAGATTTTTATTTGCCGGTAA
ATTAATGGTTCGGATAGATTGATAATGTGTCTCATATACATTTATAGA

protein sequence of SMED30015706-orf-1

>SMED30015706-orf-1 ID=SMED30015706-orf-1|Name=SMED30015706-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=342bp
MTHASGIRSSIKLTDDIKFSKENKIRCIQVKIENESLVMANHDKAEGNFE
TDYDRCIEKYLQPDQCCYILYRTDNSTKLGHEWLFLHWVPDNASIREKML
YASTRSTIKREFGESYFVEDITGHDKPDLMYSGYLKYQESKSAPPPLTLA
EQELIEIKRNERETALGDGQRTLKCSGFPPTDNLIEELTKFSNGEIDFLE
MSIEIDKETIKNDSSKSELSCDSLRSNVNPDKPRYYLYRFRHTFENESYE
PIIFIYNMPGFTSSVKERMLYSSCKAPFLEMLQSEFQLNIQRKLEVISGD
FSDLVTDNLLLDIHPPQIDSKPKITKPPGPSKRGPRRLMKD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR002108	ADF-H
IPR029006	ADF-H/Gelsolin-like_dom_sf

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Vocabulary: **molecular function**
Term	Definition
GO:0003779	actin binding

Vocabulary: **biological process**
Term	Definition
GO:0030837	negative regulation of actin filament polymerization

Main menu

Twinfilin-1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Owlery

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