Double-stranded RNA-specific adenosine deaminase

Query:  480 LNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSG--SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            LN +   + +    EP   +   +  AV + G  F  G G +KK AR  AA  A+ E+  I++      GH P    +     +      ADS  ++   K+ E+    +   +  K  A  ++T+  D  A++  VVA  +G      + L+ ++G  + +  A V+A+R+   F Y Q+ L L K+R +   E+  F   K G   L+     HLY+S +P GD     P +    L  S+K + R   G L         +  +    G + V  P +   W  ++         + +TMS TDK+  W  LG+QGALLSH + PVYL SI  G  +   H++R +  R  +E +     SY    ++  P L  V++ ++ Q       S    NW +       EII+  TG                  C   S++C     K  ++A          Y R        G     Y   K  A  Y+ +KQ LF++      G WV
Sbjct:  283 LNRLRAGLRYVCLAEPAERRARSFVMAVSVDGRTFE-GSGRSKKLARGQAAQAALQELFDIQMP-----GHAPGRARRTPMPQEF-----ADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLD--ARQAQVVALSSGTKCISGEHLS-DQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRRED--SERSIFVRLKEGGYRLRENILFHLYVSTSPCGDARLHSPYEITTDLH-SSKHLVRKFRGHL---------RTKIESGEGTVPVRGPSAVQTWDGVLLG------EQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMSHR--MEGVGQLPASY----RHNRPLLSGVSDAEARQPGKSPPFS---MNWVVGSADL--EIINATTG---------------RRSCGGPSRLC-----KHVLSARWARL-----YGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKAGLGTWV 726          

Query:  438 VSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHV---------PDTNNKKKQVTQSSDESPADSYRKIAN---SKYEELLESFSGSI--PKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC-VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKD----------YMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKH-YGEWV---PNIERNKFNL 2036
            +  Y + +     AL++ A+    +L+  E V + N+    +AF  ++ G ++  G G+NKK++R NAA  A+ E+    + + R             P   ++   V++   E     Y KI+     ++ +L+ + S  +      AAFII ER  QH     VVA G G+    S D+  + G  + +  A+V A+RSL  +FY Q+LL   K  + ++ + ++     +  +TLK    + LYM+  PKG   ++S  R    P  +S  E + + C                     H+ V      +  I L  Y  K+ +NR  +MS +DKL  W  LG+QGALLSH + PVY+ SI  G             + + +  AL  ++P+  +  NR           P++  V      Q+N  Y       NW    V+   EI+D  +G +  +SP++       +  SRL K  ML R           F +  +  +   L+         Y++ K  +  Y+  K C  +S L +H YG W+   P IE+  FN+
Sbjct:   69 IMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFII-ERAGQH----EVVAIGTGE-YNYSQDIKPD-GRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMME-KSIFCTEPTSNLLTLKQNINICLYMNQLPKGSAQIKSQLR--LNPHSISAFEANEELC--------------------LHVAV------EGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILIGDGNCSDTRGLEIAIKQRVDDALTSKLPMFYL-VNR-----------PHISLVPSAYPLQMNLEYKF--LSLNWAQGDVSL--EIVDGLSGKITESSPFK----SGMSMASRLCKAAMLSR-----------FNLLAKEAKKELLEA------GTYHAAKCMSASYQEAK-CKLKSYLQQHGYGSWIVKSPCIEQ--FNM 558          

Query:  438 VSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHV---------PDTNNKKKQVTQSSDESPADSYRKIAN---SKYEELLESFSGSI--PKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC-VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKD----------YMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKH-YGEWV---PNIERNKFNL 2036
            +  Y + +     AL++ A+    +L+  E V + N+    +AF  ++ G ++  G G+NKK++R NAA  A+ E+    + + R             P   ++   V++   E     Y KI+     ++ +L+ + S  +      AAFII ER  QH     VVA G G+    S D+  + G  + +  A+V A+RSL  +FY Q+LL   K  + ++ + ++     +  +TLK    + LYM+  PKG   ++S  R    P  +S  E + + C                     H+ V      +  I L  Y  K+ +NR  +MS +DKL  W  LG+QGALLSH + PVY+ SI  G             + + +  AL  ++P+  +  NR           P++  V      Q+N  Y       NW    V+   EI+D  +G +  +SP++       +  SRL K  ML R           F +  +  +   L+         Y++ K  +  Y+  K C  +S L +H YG W+   P IE+  FN+
Sbjct:   87 IMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFII-ERAGQH----EVVAIGTGE-YNYSQDIKPD-GRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMME-KSIFCTEPTSNLLTLKQNINICLYMNQLPKGSAQIKSQLR--LNPHSISAFEANEELC--------------------LHVAV------EGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILIGDGNCSDTRGLEIAIKQRVDDALTSKLPMFYL-VNR-----------PHISLVPSAYPLQMNLEYKF--LSLNWAQGDVSL--EIVDGLSGKITESSPFK----SGMSMASRLCKAAMLSR-----------FNLLAKEAKKELLEA------GTYHAAKCMSASYQEAK-CKLKSYLQQHGYGSWIVKSPCIEQ--FNM 576          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRD--WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ I         N H+  T +++   ++       +  AD+  ++   K+ +L ++FS    +R   A  ++T   D   K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      ++  F+  + G   LK   + HLY+S +P GD     P +   EEP   + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +       E+I+  T            G DE  + SRL K  +  R    ++  +    +R +  +              Y+  K +A +Y+  K  LF + +    G WV    E+++F+L
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALAAI--------FNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTD--VKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQ---KRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEP---ADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVG--DSAIEVINATT------------GKDELGRASRLCKHALYCRWMR-VHGKVPSHLLRSKITKPNV-----------YHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSL 699          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRD--WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ I         N H+  T +++   ++       +  AD+  ++   K+ +L ++FS    +R   A  ++T   D   K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      ++  F+  + G   LK   + HLY+S +P GD     P +   EEP   + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +       E+I+  T            G DE  + SRL K  +  R    ++  +    +R +  +              Y+  K +A +Y+  K  LF + +    G WV    E+++F+L
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALAAI--------FNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTD--VKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQ---KRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEP---ADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVG--DSAIEVINATT------------GKDELGRASRLCKHALYCRWMR-VHGKVPSHLLRSKITKPNV-----------YHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSL 699          

Query:  729 SSDESP---ADSYRKIANSKYEELLESFSG-SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRS-------NLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDS-NQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            SS E P   AD+  ++   K+ E+++     S  K  A  ++TE  + +  E  V++   G      + ++ N G  + +  A ++++R L  + Y Q+ L  ++  +       N  G+  Y          LK G   HLY++ AP GD     P + +  +    K  +R   G+L         +  +    G I V   D    W  ++  +      R +TMS +DK+  W  +GIQG+LLS ++ PVYL+SI  G     EH+ RA+  R+  ++I      Y+ +     P L  VT  +  NQ  +         NW +   TEL E+++  TG           GG    + SR++K    ++    + A +    +R                  DY   K +  DY+  K  LF +   +  G W+   IE+++F L E
Sbjct:  250 SSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTE--NMNFCEAKVISVSTGTKCVSGEHMSVN-GAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVRNTDGQYPY---------KLKSGVHFHLYINTAPCGDARIFSPHENDTGV---DKHPNRKARGQL---------RTKIESGEGTIPVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIE-KSIQGLPPPYHLN----KPRLALVTSAEPRNQAKA----PNFGINWTIGD-TEL-EVVNSLTG--------RTIGG----QVSRITKQAFFVKYG-FLMANLPGILVR--------------KVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE 632          

Query:  729 SSDESP---ADSYRKIANSKYEELLESFSG-SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRS-------NLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDS-NQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            SS E P   AD+  ++   K+ E+++     S  K  A  ++TE  + +  E  V++   G      + ++ N G  + +  A ++++R L  + Y Q+ L  ++  +       N  G+  Y          LK G   HLY++ AP GD     P + +  +    K  +R   G+L         +  +    G I V   D    W  ++  +      R +TMS +DK+  W  +GIQG+LLS ++ PVYL+SI  G     EH+ RA+  R+  ++I      Y+ +     P L  VT  +  NQ  +         NW +   TEL E+++  TG           GG    + SR++K    ++    + A +    +R                  DY   K +  DY+  K  LF +   +  G W+   IE+++F L E
Sbjct:  250 SSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTE--NMNFCEAKVISVSTGTKCVSGEHMSVN-GAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVRNTDGQYPY---------KLKSGVHFHLYINTAPCGDARIFSPHENDTGV---DKHPNRKARGQL---------RTKIESGEGTIPVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIE-KSIQGLPPPYHLN----KPRLALVTSAEPRNQAKA----PNFGINWTIGD-TEL-EVVNSLTG--------RTIGG----QVSRITKQAFFVKYG-FLMANLPGILVR--------------KVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE 632          

Query:  729 SSDESP---ADSYRKIANSKYEELLESFSG-SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRS-------NLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDS-NQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            SS E P   AD+  ++   K+ E+++     S  K  A  ++TE  + +  E  V++   G      + ++ N G  + +  A ++++R L  + Y Q+ L  ++  +       N  G+  Y          LK G   HLY++ AP GD     P + +  +    K  +R   G+L         +  +    G I V   D    W  ++  +      R +TMS +DK+  W  +GIQG+LLS ++ PVYL+SI  G     EH+ RA+  R+  ++I      Y+ +     P L  VT  +  NQ  +         NW +   TEL E+++  TG           GG    + SR++K    ++    + A +    +R                  DY   K +  DY+  K  LF +   +  G W+   IE+++F L E
Sbjct:  229 SSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTE--NMNFCEAKVISVSTGTKCVSGEHMSVN-GAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVRNTDGQYPY---------KLKSGVHFHLYINTAPCGDARIFSPHENDTGV---DKHPNRKARGQL---------RTKIESGEGTIPVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIE-KSIQGLPPPYHLN----KPRLALVTSAEPRNQAKA----PNFGINWTIGD-TEL-EVVNSLTG--------RTIGG----QVSRITKQAFFVKYG-FLMANLPGILVR--------------KVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE 611          

Query:  729 SSDESP---ADSYRKIANSKYEELLESFSG-SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVT--LKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDS-NQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            SS E P   AD+  ++   K+ E+++     S  K  A  ++TE  + +  E  V++   G      + ++ N G  + +  A ++++R L  + Y Q    LD + +     +  F    +G     LK G   HLY++ AP GD     P + +  +    K  +R   G+L         +  +    G I V   D    W  ++  +      R +TMS +DK+  W  +GIQG+LLS ++ PVYL+SI  G     EH+ RA+  R+  ++I      Y+ +     P L  VT  +  NQ  +         NW +   TEL E+++  TG           GG    + SR++K    ++    + A +    +R                  DY   K +  DY+  K  LF +   +  G W+   IE+++F L E
Sbjct:  287 SSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTE--NMNFCEAKVISVSTGTKCVSGEHMSVN-GAVLNDSHAEIVSRRCLLKYLYAQ----LDLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGV---DKHPNRKARGQL---------RTKIESGEGTIPVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIE-KSIQGLPPPYHLN----KPRLALVTSAEPRNQAKA----PNFGINWTIGD-TEL-EVVNSLTG--------RTIGG----QVSRITKQAFFVKYG-FLMANLPGILVR--------------KVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE 669          

Query:  729 SSDESP---ADSYRKIANSKYEELLESFSG-SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVT--LKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDS-NQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            SS E P   AD+  ++   K+ E+++     S  K  A  ++TE  + +  E  V++   G      + ++ N G  + +  A ++++R L  + Y Q    LD + +     +  F    +G     LK G   HLY++ AP GD     P + +  +    K  +R   G+L         +  +    G I V   D    W  ++  +      R +TMS +DK+  W  +GIQG+LLS ++ PVYL+SI  G     EH+ RA+  R+  ++I      Y+ +     P L  VT  +  NQ  +         NW +   TEL E+++  TG           GG    + SR++K    ++    + A +    +R                  DY   K +  DY+  K  LF +   +  G W+   IE+++F L E
Sbjct:  283 SSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTE--NMNFCEAKVISVSTGTKCVSGEHMSVN-GAVLNDSHAEIVSRRCLLKYLYAQ----LDLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGV---DKHPNRKARGQL---------RTKIESGEGTIPVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIE-KSIQGLPPPYHLN----KPRLALVTSAEPRNQAKA----PNFGINWTIGD-TEL-EVVNSLTG--------RTIGG----QVSRITKQAFFVKYG-FLMANLPGILVR--------------KVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE 665          

Query:  408 NSKIES-----ARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVP-DTNN----------KKKQVTQSSD-------ESPA-DSYRKIANSKYEELLES---FSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWE-EPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTET---DSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            N+KI S      R ++  Y +       AL ++++ + ++L+  E V +  +    +AF  +I G ++  G G  KK+AR  A+  A+ E+   L+    N  +P DT+           K+  +TQ          ++P  D    +    + +L+++   FSG      AAF++            VVA G G    K+      R   + +  A+V A+RSL  F Y  +LL      S LK + V+ +      ++ K+   LHLY+S  PKG     IP      PL +S  E++                  I L    H+ V     E +  S  +   +   +  V+MS TDK+M W  LG QGALLSH + P+Y+ SI  G     +     +     ++ I S    YY     + P++  V+     D+ Q            NW    +T   E++D   G    +SP++          SRL K  M  R          +  +  E QR   L  +       Y   K  A  Y+  K  L   L  K YG+WV
Sbjct:   49 NNKINSKPKILPRELIDRYKRGDTHPVSALYQLSQVLQFQLDLKETVTTAGISGFYFAFCAVIDGIQYKTGMGTTKKEARAKASELALKELLASLE----NDEIPSDTDTVGPPPLPVREKESTITQIHSGRAVIERKNPIKDQVPSVVREMFTKLMDNYPEFSG-CGGTLAAFVMLS-----PTGCEVVALGTGSSNTKASPAPTGR--ILHDSHAVVTARRSLMRFLYRNLLLFFSNN-SALKEKSVFQQDETTKLLSFKNHITLHLYLSQLPKG--ASQIPSQLRLNPLSISAWEVN----------------NQISL----HVVV-----EGKVFSKFSSSYEQMGSHVVSMSATDKVMQWQVLGFQGALLSHFIEPIYMSSIFIGDGSCSDIRGMEMAVNQRVDGITSALPLYY---CVYRPHISLVSSAIPPDTRQTQKFLS-----LNWSHEDLTL--EMVDALEGKSTEDSPFK----SSPALASRLCKAAMFSR----------FNLVAKESQREELLTAVT------YREAKMMAKPYQEAKSMLKSYLERKGYGQWV 546          

Query:  408 NSKIES-----ARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVP-DTNN----------KKKQVTQSSD-------ESPA-DSYRKIANSKYEELLES---FSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWE-EPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTET---DSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            N+KI S      R ++  Y +       AL ++++ + ++L+  E V +  +    +AF  +I G ++  G G  KK+AR  A+  A+ E+   L+    N  +P DT+           K+  +TQ          ++P  D    +    + +L+++   FSG      AAF++            VVA G G    K+      R   + +  A+V A+RSL  F Y  +LL      S LK + V+ +      ++ K+   LHLY+S  PKG     IP      PL +S  E++                  I L    H+ V     E +  S  +   +   +  V+MS TDK+M W  LG QGALLSH + P+Y+ SI  G     +     +     ++ I S    YY     + P++  V+     D+ Q            NW    +T   E++D   G    +SP++          SRL K  M  R          +  +  E QR   L  +       Y   K  A  Y+  K  L   L  K YG+WV
Sbjct:   49 NNKINSKPKILPRELIDRYKRGDTHPVSALYQLSQVLQFQLDLKETVTTAGISGFYFAFCAVIDGIQYKTGMGTTKKEARAKASELALKELLASLE----NDEIPSDTDTVGPPPLPVREKESTITQIHSGRAVIERKNPIKDQVPSVVREMFTKLMDNYPEFSG-CGGTLAAFVMLS-----PTGCEVVALGTGSSNTKASPAPTGR--ILHDSHAVVTARRSLMRFLYRNLLLFFSNN-SALKEKSVFQQDETTKLLSFKNHITLHLYLSQLPKG--ASQIPSQLRLNPLSISAWEVN----------------NQISL----HVVV-----EGKVFSKFSSSYEQMGSHVVSMSATDKVMQWQVLGFQGALLSHFIEPIYMSSIFIGDGSCSDIRGMEMAVNQRVDGITSALPLYY---CVYRPHISLVSSAIPPDTRQTQKFLS-----LNWSHEDLTL--EMVDALEGKSTEDSPFK----SSPALASRLCKAAMFSR----------FNLVAKESQREELLTAVT------YREAKMMAKPYQEAKSMLKSYLERKGYGQWV 546          

Query:  408 NSKIES-----ARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVP-DTNN----------KKKQVTQSSD-------ESPA-DSYRKIANSKYEELLES---FSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWE-EPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTET---DSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            N+KI S      R ++  Y +       AL ++++ + ++L+  E V +  +    +AF  +I G ++  G G  KK+AR  A+  A+ E+   L+    N  +P DT+           K+  +TQ          ++P  D    +    + +L+++   FSG      AAF++            VVA G G    K+      R   + +  A+V A+RSL  F Y  +LL      S LK + V+ +      ++ K+   LHLY+S  PKG     IP      PL +S  E++                  I L    H+ V     E +  S  +   +   +  V+MS TDK+M W  LG QGALLSH + P+Y+ SI  G     +     +     ++ I S    YY     + P++  V+     D+ Q            NW    +T   E++D   G    +SP++          SRL K  M  R          +  +  E QR   L  +       Y   K  A  Y+  K  L   L  K YG+WV
Sbjct:   49 NNKINSKPKILPRELIDRYKRGDTHPVSALYQLSQVLQFQLDLKETVTTAGISGFYFAFCAVIDGIQYKTGMGTTKKEARAKASELALKELLASLE----NDEIPSDTDTVGPPPLPVREKESTITQIHSGRAVIERKNPIKDQVPSVVREMFTKLMDNYPEFSG-CGGTLAAFVMLS-----PTGCEVVALGTGSSNTKASPAPTGR--ILHDSHAVVTARRSLMRFLYRNLLLFFSNN-SALKEKSVFQQDETTKLLSFKNHITLHLYLSQLPKG--ASQIPSQLRLNPLSISAWEVN----------------NQISL----HVVV-----EGKVFSKFSSSYEQMGSHVVSMSATDKVMQWQVLGFQGALLSHFIEPIYMSSIFIGDGSCSDIRGMEMAVNQRVDGITSALPLYY---CVYRPHISLVSSAIPPDTRQTQKFLS-----LNWSHEDLTL--EMVDALEGKSTEDSPFK----SSPALASRLCKAAMFSR----------FNLVAKESQREELLTAVT------YREAKMMAKPYQEAKSMLKSYLERKGYGQWV 546          

Query:  468 AAQALNEIAKAMVWELEFEPVH----SKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHV-PDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSED----EWISLV-TYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            A   L E A+A  +  E   V     S   ++ +   + G  F      NKK  +Q AA  A+  +    ++  R G + P+           S  +  D    +++ ++  L      S+  R     I  R    +  G VV+ G G    K ++L+  RG  + +  A +I++R    F Y++++     K     G++  FE+  +G + +K     HLY+S AP GD              L  K        +L    +M   +NI   + G +R    + E     E   +V T+       R  TMS +DK++ W  LG+QGALL+H ++P+YL+SI  G  Y H H++RA+ CR+  +  ++ + S   +     P + RV+  DS +  S     ++  NW   P     E++D   G +  +SP          + SR+SK   L RL         + A+     R   L          Y   K +A  ++  K+  F +L    YG W+
Sbjct:  869 AVSGLLEYARARGFAAEIRLVGQSGPSHEPKFTYQAKLGGRWFPAVCASNKKQGKQEAADAALRVLIGEAEKAARTGELMPEL--------PVSGSTIHDQIAMLSHQRFNALTARIQHSLLGRKILATIVMRNGTDSL-GKVVSLGTGNRCVKGEELSL-RGDTVNDCHAEIISRRGFIRFLYSELM-----KHWESPGDETIFELAGDGKLKIKSDITFHLYISTAPCGDGA------------LFDKSCSE--AAELNGSGHMPLFENI---KQGKLRTKVENGEGTIPVESSDIVPTWDGIQHGERLRTMSCSDKILRWNVLGLQGALLTHFIHPIYLHSITLGYLYSHGHLTRAVCCRLSRDG-DTFKSSLPANFTLNHPEVGRVSVYDSTRHTS--KTKESSVNWS-QPDQYSVEVLDGTKGKL--DSP--------KMEVSRVSK-SNLFRL---------FHALCQRAGRADLL------ALQSYAHAKMAATSFQEAKRLFFLALSQHGYGAWI 1329          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFE-VGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK-------VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K A   LNE+   + +E   E   S    +  +V +   +F  G G NKK A+  AA  A+S +  ++L +      +P     ++ +     +  AD+  ++   K+ EL ++FS    +R   A  ++T   D    +  V+    G      + +++ RG  + +  A +IA+RSL  + YNQ+   L    S  + EK  F    ++GY  LK   + HLY+S +P GD     P +     +   +  +R   G+L         +  +    G I V   ++   W  ++      +  R +TMS +DK+  W  +G+QG+LLS+   P+Y  S+  G  Y  +H+SRA+  R+      ++        +   P L  ++ T++ Q     + S    NW +    +  EII+  T            G D+  + S+L K       VC+  +L E++                     I G+    Y+  K  AV+Y   KQ LF++      G WV   IE+++F+L
Sbjct:  253 KNAVMILNELRPGLKYEFVAESGESHAKNFIMSVTVDTQKFQ-GSGRNKKLAKARAAQAALSGLFNMQLDQTPSRQPIP-----REGLQLHLPQVLADAVSRLVVDKFSELTDNFSSPHARRKVLAGVVMTTGKD--VMDAQVICVTTGTKCINGEYMSD-RGLALNDCHAEIIARRSLIRYLYNQLEYFLSD--STEEHEKSIFRWCSEHGY-RLKDDIQFHLYISTSPCGDARIFSPHEAGAEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRTSNTIQTWDGVL------QGERLLTMSCSDKIARWNVIGVQGSLLSYFTEPIYFSSLILGSLYHADHLSRAMYQRI------ADMDDIPPPFRINRPLLSGISNTEARQPGKAPNFS---VNWTVG--DQGLEIINATT------------GKDDLGRQSQLCKHALYSRWVCLHAKLSETLR--------------------IRGSRPGSYHEAKQGAVEYHEAKQTLFKAFYKAGLGAWVEKPIEQDQFSL 718          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYF----DPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V +  NE   G G NKK A+  AA  A++ +         N H+  T +++   ++       +  AD+  ++   K+ +L ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I++RSL  F Y Q+ L L  K      ++  F   + G   LK   + HLY+S +P GD     P +  +  +   +  +R   G+L         +  +    G I V    +   W  ++      +  R +TMS +DKL  W  +GIQG+LLS  + P+YL SI  G  Y  +H+SRA+  R+          S  E + +      P L  ++  ++ Q       S    NW +       E+I+  T            G DE  + SRL K  +  R             MR   + +  ++     CK      Y+  K SAV+Y+  K+C+F+       G WV   IE+++F+L
Sbjct:  221 KNPVMILNELRPGLKYDFVSESGESHAKNFVMSVTVD-NETFEGSGRNKKLAKARAAQSALASL--------FNMHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVVDKFSDLTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLVRFLYTQLELFLSTKEDQ---QRSIFMKSERGGFKLKDNVQFHLYISTSPCGDARIFSPHEAGQEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSSTIQTWDGVL------QGERLLTMSCSDKLARWNVVGIQGSLLSLFVEPIYLSSIILGSLYHGDHLSRAVYQRI----------SDIEDLPHLYALNKPLLSGISNAEARQPGKAPSFS---VNWAVGDSGL--EVINATT------------GKDEMGRASRLCKHALYSRW------------MRIHAKLSSSVR-----CKIGKLNVYHDTKHSAVEYQSAKECVFKVFQKSGLGAWVKKPIEQDQFSL 685          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYF----DPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V +  NE   G G NKK A+  AA  A++ +         N H+  T +++   ++       +  AD+  ++   K+ +L ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I++RSL  F Y Q+ L L  K      ++  F   + G   LK   + HLY+S +P GD     P +  +  +   +  +R   G+L         +  +    G I V    +   W  ++      +  R +TMS +DKL  W  +GIQG+LLS  + P+YL SI  G  Y  +H+SRA+  R+          S  E + +      P L  ++  ++ Q       S    NW +       E+I+  T            G DE  + SRL K  +  R             MR   + +  ++     CK      Y+  K SAV+Y+  K+C+F+       G WV   IE+++F+L
Sbjct:  226 KNPVMILNELRPGLKYDFVSESGESHAKNFVMSVTVD-NETFEGSGRNKKLAKARAAQSALASL--------FNMHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVVDKFSDLTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLVRFLYTQLELFLSTKEDQ---QRSIFMKSERGGFKLKDNVQFHLYISTSPCGDARIFSPHEAGQEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSSTIQTWDGVL------QGERLLTMSCSDKLARWNVVGIQGSLLSLFVEPIYLSSIILGSLYHGDHLSRAVYQRI----------SDIEDLPHLYALNKPLLSGISNAEARQPGKAPSFS---VNWAVGDSGL--EVINATT------------GKDEMGRASRLCKHALYSRW------------MRIHAKLSSSVR-----CKIGKLNVYHDTKHSAVEYQSAKECVFKVFQKSGLGAWVKKPIEQDQFSL 690          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYF----DPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V +  NE   G G NKK A+  AA  A++ +         N H+  T +++   ++       +  AD+  ++   K+ +L ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I++RSL  F Y Q+ L L  K      ++  F   + G   LK   + HLY+S +P GD     P +  +  +   +  +R   G+L         +  +    G I V    +   W  ++      +  R +TMS +DKL  W  +GIQG+LLS  + P+YL SI  G  Y  +H+SRA+  R+          S  E + +      P L  ++  ++ Q       S    NW +       E+I+  T            G DE  + SRL K  +  R             MR   + +  ++     CK      Y+  K SAV+Y+  K+C+F+       G WV   IE+++F+L
Sbjct:  233 KNPVMILNELRPGLKYDFVSESGESHAKNFVMSVTVD-NETFEGSGRNKKLAKARAAQSALASL--------FNMHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVVDKFSDLTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLVRFLYTQLELFLSTKEDQ---QRSIFMKSERGGFKLKDNVQFHLYISTSPCGDARIFSPHEAGQEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSSTIQTWDGVL------QGERLLTMSCSDKLARWNVVGIQGSLLSLFVEPIYLSSIILGSLYHGDHLSRAVYQRI----------SDIEDLPHLYALNKPLLSGISNAEARQPGKAPSFS---VNWAVGDSGL--EVINATT------------GKDEMGRASRLCKHALYSRW------------MRIHAKLSSSVR-----CKIGKLNVYHDTKHSAVEYQSAKECVFKVFQKSGLGAWVKKPIEQDQFSL 697          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYF----DPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V +  NE   G G NKK A+  AA  A++ +         N H+  T +++   ++       +  AD+  ++   K+ +L ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I++RSL  F Y Q+ L L  K      ++  F   + G   LK   + HLY+S +P GD     P +  +  +   +  +R   G+L         +  +    G I V    +   W  ++      +  R +TMS +DKL  W  +GIQG+LLS  + P+YL SI  G  Y  +H+SRA+  R+          S  E + +      P L  ++  ++ Q       S    NW +       E+I+  T            G DE  + SRL K  +  R             MR   + +  ++     CK      Y+  K SAV+Y+  K+C+F+       G WV   IE+++F+L
Sbjct:  230 KNPVMILNELRPGLKYDFVSESGESHAKNFVMSVTVD-NETFEGSGRNKKLAKARAAQSALASL--------FNMHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVVDKFSDLTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLVRFLYTQLELFLSTKEDQ---QRSIFMKSERGGFKLKDNVQFHLYISTSPCGDARIFSPHEAGQEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSSTIQTWDGVL------QGERLLTMSCSDKLARWNVVGIQGSLLSLFVEPIYLSSIILGSLYHGDHLSRAVYQRI----------SDIEDLPHLYALNKPLLSGISNAEARQPGKAPSFS---VNWAVGDSGL--EVINATT------------GKDEMGRASRLCKHALYSRW------------MRIHAKLSSSVR-----CKIGKLNVYHDTKHSAVEYQSAKECVFKVFQKSGLGAWVKKPIEQDQFSL 694          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYF----DPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V +  NE   G G NKK A+  AA  A++ +         N H+  T +++   ++       +  AD+  ++   K+ +L ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I++RSL  F Y Q+ L L  K      ++  F   + G   LK   + HLY+S +P GD     P +  +  +   +  +R   G+L         +  +    G I V    +   W  ++      +  R +TMS +DKL  W  +GIQG+LLS  + P+YL SI  G  Y  +H+SRA+  R+          S  E + +      P L  ++  ++ Q       S    NW +       E+I+  T            G DE  + SRL K  +  R             MR   + +  ++     CK      Y+  K SAV+Y+  K+C+F+       G WV   IE+++F+L
Sbjct:  253 KNPVMILNELRPGLKYDFVSESGESHAKNFVMSVTVD-NETFEGSGRNKKLAKARAAQSALASL--------FNMHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVVDKFSDLTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLVRFLYTQLELFLSTKEDQ---QRSIFMKSERGGFKLKDNVQFHLYISTSPCGDARIFSPHEAGQEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSSTIQTWDGVL------QGERLLTMSCSDKLARWNVVGIQGSLLSLFVEPIYLSSIILGSLYHGDHLSRAVYQRI----------SDIEDLPHLYALNKPLLSGISNAEARQPGKAPSFS---VNWAVGDSGL--EVINATT------------GKDEMGRASRLCKHALYSRW------------MRIHAKLSSSVR-----CKIGKLNVYHDTKHSAVEYQSAKECVFKVFQKSGLGAWVKKPIEQDQFSL 717          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRD--WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ +         N H+  T +++  +++       +  AD+  ++   K+ +L ++FS    +R     +        K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      +K  F+  + G   LK   + HLY+S +P GD     P +   EEP   + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +   T   E+I+  T            G DE  + SRL K    C  +R+   +          P   RT+  +         Y+  K +A +Y+  K  LF + +    G WV    E+++F+ 
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALATV--------FNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQ---KKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEEP---ADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLN-------------KPLLSGISNAEARQPGKAPNFS---VNWTVGDATI--EVINATT------------GKDELGRPSRLCKHALYCRWMRVHGKVP---------PHLLRTKITKPTT------YHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSF 699          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC---------VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ +         N H+  T +++  +++       +  AD+  ++   K+ +L ++FS    +R     +        K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      +K  F+  + G   LK   + HLY+S +P GD          +E +  D  +    + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +   T   E+I+  T            G DE  + SRL K    C  +R+   +          P   RT+  +         Y+  K +A +Y+  K  LF + +    G WV    E+++F+ 
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALATV--------FNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQ---KKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVGDATI--EVINATT------------GKDELGRPSRLCKHALYCRWMRVHGKVP---------PHLLRTKITKPTT------YHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSF 709          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC---------VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ +         N H+  T +++  +++       +  AD+  ++   K+ +L ++FS    +R     +        K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      +K  F+  + G   LK   + HLY+S +P GD          +E +  D  +    + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +   T   E+I+  T            G DE  + SRL K    C  +R+   +          P   RT+  +         Y+  K +A +Y+  K  LF + +    G WV    E+++F+ 
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALATV--------FNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQ---KKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVGDATI--EVINATT------------GKDELGRPSRLCKHALYCRWMRVHGKVP---------PHLLRTKITKPTT------YHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSF 709          

Query:  438 VSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNR--NGHVPDTNNKKKQVTQSSDESPADSY--RKIANSKYEELLESFSGSIPKRY----------AAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKD----------YMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV---PNIER 2021
            +  Y + +     AL++ A+    +L+  E V + N+    +AF  ++ G ++  G G+NKK++R NAA  A+ E+    + + R      P     +  VT  +       Y  R++  +K  +L++   G +   +          AAFII ER   H     VVA G G+         +  G  + +  A+V A+RSL  +FY Q+LL   K  + ++      E   N  +TLK    L+LYM+  PKG          +  LRL+   I              ++  N  L    H+ V      +  I L  Y + + +NR  +MS +DKL  W  LG+QGALLSH + PVY+ SI  G             +++ +  AL  ++P+  +  NR           P++  V      QIN   D+     NW     +   EI+D   G +  +SP++       +  SRL K  ML R          +  +  E +    L+         Y++ K  +  Y+  K  L   L    YG W+   P IE+
Sbjct:  129 IMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRVLEPAGPPPIPAEPVVTPEAAYVSKVQYEGRQVQYAKISQLVKETFGQLISNHSQYLKCSSSLAAFII-ERAGHH----EVVAIGTGE--YNYSQCIKPNGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPASN-LLTLKQNINLYLYMNQLPKGSA------QIKSQLRLNPHSIS-------------AFEANEELSL--HVAV------EGKIYLTVYCSADGVNRVNSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILVGDGNCNDTRGLEIAINQRVDDALTSKLPMFYL-VNR-----------PHISLVPTAYPLQIN--LDHKSLSLNWAQGDNSL--EIVDGLNGKITESSPFK----SGLSMASRLCKAAMLSR----------FNLLAKEAKTDDLLEA------RTYHAAKCMSGPYQEAKALLKAYLQQHGYGSWIVKSPCIEQ 616          

Query:  549 YAFAVLISGNEFAVGEGENKKDARQNAAAEAISE-IKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIP--KRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            +  AV + G  F  G G +KK A+  AA  A+     IRL      GH+P + +K   + Q      ADS  ++   K+ EL    +      K  A  ++T+  D   K+  V+   +G      + +++ +G  + +  A ++A+R+   F Y+Q+ L L K + + +   ++  + + GY  L+     HLY+S +P GD   + P +    L  S+K I R   G L         +  +    G + V  P +   W  ++         + +TMS TDK+ SW  LG+QGALL H + PVYL+SI  G  +   H++R +  R  +E I     SY ++     P L  V+  ++ Q       S    NW +       EII+  TG                  C   S++C     K   +A   ++A       TR     +G     Y   K  A  Y+ +KQ LF++      G WV
Sbjct:  312 FVMAVCVDGRTFE-GSGRSKKLAKGQAAQAALQALFDIRLP-----GHIP-SRSKSNLLPQDF----ADSVSQLVTQKFRELTVGLTSVYARHKTLAGIVMTKGLD--TKQAQVIVLSSGTKCISGEHISD-QGLVVNDCHAEIVARRAFLHFLYSQLELHLSKHQEDPE-RSIFIRLKEGGY-RLRENILFHLYVSTSPCGDARVNSPYEITTDLN-SSKHIVRKFRGHL---------RTKIESGEGTVPVRGPSAVQTWDGILLG------EQLITMSCTDKIASWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHR--MEGIGQLPASYRQN----RPLLSGVSHAEARQPGKSPHFSA---NWVVGSADL--EIINATTG---------------KRSCGGSSRLC-----KHVFSA---WWARLHGRLSTRIPS--HGDTPSMYCEAKQGAHTYQSVKQQLFKAFQKAGLGTWV 732          

Query:  480 LNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSG--SIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            LN +   + +    EP   +   +  AV + G  F  G G +KK AR  AA  A+ E+  I++      GH P    +     +      ADS  ++   K+ E+    +   +  K  A  ++T+  D  A++  VVA  +G      + L+ ++G  + +  A V+A+R+   F Y Q+ L L K+R +   E+  F   K G   L+     HLY+S +P GD     P +    L  S+K + R   G L         +  +    G + V  P +   W  ++         + +TMS TDK+  W  LG+QGALLSH + PVYL SI  G  +   H++R +  R  +E +     SY    ++  P L  V++ ++ Q       S    NW +       EII+  TG                  C   S++C     K  ++A          Y R        G     Y   K  A  Y+ +KQ LF++      G WV
Sbjct:  283 LNRLRAGLRYVCLAEPAERRARSFVMAVSVDGRTFE-GSGRSKKLARGQAAQAALQELFDIQMP-----GHAPGRARRTPMPQEF-----ADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLD--ARQAQVVALSSGTKCISGEHLS-DQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRRED--SERSIFVRLKEGGYRLRENILFHLYVSTSPCGDARLHSPYEITTDLH-SSKHLVRKFRGHL---------RTKIESGEGTVPVRGPSAVQTWDGVLLG------EQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMSHR--MEGVGQLPASY----RHNRPLLSGVSDAEARQPGKSPPFS---MNWVVGSADL--EIINATTG---------------RRSCGGPSRLC-----KHVLSARWARL-----YGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKAGLGTWV 726          

Query:  438 VSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHV---------PDTNNKKKQVTQSSDESPADSYRKIAN---SKYEELLESFSGSI--PKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC-VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKD----------YMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKH-YGEWV---PNIERNKFNL 2036
            +  Y + +     AL++ A+    +L+  E V + N+    +AF  ++ G ++  G G+NKK++R NAA  A+ E+    + + R             P   ++   V++   E     Y KI+     ++ +L+ + S  +      AAFII ER  QH     VVA G G+    S D+  + G  + +  A+V A+RSL  +FY Q+LL   K  + ++ + ++     +  +TLK    + LYM+  PKG   ++S  R    P  +S  E + + C                     H+ V      +  I L  Y  K+ +NR  +MS +DKL  W  LG+QGALLSH + PVY+ SI  G             + + +  AL  ++P+  +  NR           P++  V      Q+N  Y       NW    V+   EI+D  +G +  +SP++       +  SRL K  ML R           F +  +  +   L+         Y++ K  +  Y+  K C  +S L +H YG W+   P IE+  FN+
Sbjct:   87 IMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFII-ERAGQH----EVVAIGTGE-YNYSQDIKPD-GRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMME-KSIFCTEPTSNLLTLKQNINICLYMNQLPKGSAQIKSQLR--LNPHSISAFEANEELC--------------------LHVAV------EGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILIGDGNCSDTRGLEIAIKQRVDDALTSKLPMFYL-VNR-----------PHISLVPSAYPLQMNLEYKF--LSLNWAQGDVSL--EIVDGLSGKITESSPFK----SGMSMASRLCKAAMLSR-----------FNLLAKEAKKELLEA------GTYHAAKCMSASYQEAK-CKLKSYLQQHGYGSWIVKSPCIEQ--FNM 576          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC---------VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ +         N H+  T +++  +++       +  AD+  ++   K+ +L ++FS    +R     +        K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      +K  F+  + G   LK   + HLY+S +P GD          +E +  D  +    + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQG+LLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +   T   E+I+  T            G DE  + SRL K    C  +R+   +          P   RT+  +         Y+  K +A +Y+  K  LF + +    G WV    E+++F+ 
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALATV--------FNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQ---KKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVGDATI--EVINATT------------GKDELGRPSRLCKHALYCRWMRVHGKVP---------PHLLRTKITKPTT------YHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSF 709          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSD----ESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDC---------VESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-------PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            K     LNE+   + ++   E   S    +  +V++ G +F  G G NKK A+  AA  A++ +         N H+  T +++  +++       +  AD+  ++   K+ +L ++FS    +R     +        K+  V++   G      + +++ RG  + +  A +I++RSL  F Y Q+ L L+ K      +K  F+  + G   LK   + HLY+S +P GD          +E +  D  +    + +  +R   G+L         +  +    G I V    S   W  ++      +  R +TMS +DK+  W  +GIQGALLS  + P+Y  SI  G  Y  +H+SRA+  R+       PL  +N              P L  ++  ++ Q     + S    NW +       E+I+  T            G DE  + SRL K    C  +R+   +          P   RT+  +         Y+  K +A +Y+  K  LF + +    G WV    E+++F+ 
Sbjct:  234 KNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDG-QFFEGSGRNKKLAKARAAQSALATV--------FNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSD-RGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQ---KKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQL---------RTKIESGEGTIPVRSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNK-------------PLLSGISNAEARQPGKAPNFS---VNWTVGDTAI--EVINATT------------GKDELGRPSRLCKHALYCRWMRVHGKVP---------PHLLRTKITKPTT------YHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSF 709          

Query:  438 VSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSY--------RKIANSKYEELL-ESFSGSIPKR---------YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKD----------YMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV---PNIER 2021
            +  Y + +     AL++ A+    +L+  E V + N+    +AF  ++ G ++  G G+NKK++R NAA  A+ E+ ++L         P        +      +P  +Y        R++  +K  +L+ E+FS  I             AAFII ER   H     VVA G G+    S  +  N G  + +  A+V A+RSL  +FY Q+LL   K  + ++      E   N  +TLK    L+LYM+  PKG          +  LRL+   I              ++  N  L    H+ V      +  I L  Y + + +NR  +MS +DKL  W  LG+QGALLSH + PVY+ SI  G             +++ +  AL  ++P+  +  NR           P++  V      QIN   D+     NW     +   EI+D  +G +  +SP++       +  SRL K  ML R          +  +  E +    L+         Y++ K  +  Y+  K  L   L    YG W+   P IE+
Sbjct:  129 IMKYRRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDEL-LQLDEPEPRALEPA---GPPPIPAEPIVTPEAAYISKVQYEGRQVQYAKISQLVKETFSQLISSHSQYLKCSSSLAAFII-ERGGHH----EVVAIGTGE-YNYSQCIKPN-GRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPASN-LLTLKQNINLYLYMNQLPKGSA------QIKSQLRLNPHSIS-------------AFEANEELSL--HVAV------EGKIYLTVYCSADGVNRVNSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILVGDGNCNDTRGLEIAINQRVDDALTSKLPMFYL-VNR-----------PHISLVPTAYPLQIN--LDHKSLSLNWAQGDNSL--EIVDGLSGKITESSPFK----SGLSMASRLCKAAMLSR----------FNLLAKEAKTDDLLEA------RTYHAAKCLSGPYQEAKALLKAYLQQHGYGSWIVKSPCIEQ 616          

Query:  444 SYLKNQKTAAQALNEIAKAMVWELEFEPVH-SKNL-RYAFAVL--ISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKK----QVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAK---EGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGY-VTLKHGCRLHLYMSHAPKGDCVESIPRD-WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTG-CVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            +Y    K    ALNE A+    E+ FE V   +N  R  F +   +  + F      N KDAR+ AA  A+  I      Q+ +G  P +   K+    Q +  S       +  IA   +   L+  + SIP ++A   +       A     G VV+ GAG        L+   G  + +  A +IA+RSL  FFY Q+        ++  G+K  FE   N   + ++ G   HLY+S AP GD     PR+     L  S  E       KL+ I+             G I V   D    W  LV      +  R  TMS +DK+  W  LG+QGALLSH + PVYL S+  G  Y H H++RA+ CR  L++          S +   P+L RVT  D  +     +N     NW         E+ D RTG C+   +    P        SRL K  +    KE               QRT     ++      Y+  K  AV+++  K+ LFE      YG+WV
Sbjct:    8 AYAAINKNPVSALNEYAQKNRMEVAFEVVKDGRNFNRPPFTMFARVGPHRFPSATSSNMKDARREAADMALRAIV----GQSASGSGPTSGRSKEVFLSQPSPGSLSGVRTHFDLIAALAHHAFLQ-IAASIPDKFAGRKVVACIIMKASLEDSGRVVSLGAGNRCVTGQRLSME-GKVVNDSHAEIIARRSLLRFFYAQL-------HAHFDGQKSIFEKRNNSRRLAVRQGVSFHLYISTAPCGDGALFTPREGLNTDLSESKMEHKPAFTSKLQGILRTKIEDG-----EGTIPVDPSDGPQTWDGLV------QGGRLRTMSCSDKICRWNALGLQGALLSHFIEPVYLESLTLGYLYDHGHLARAVCCR--LQHKVDLGAELTGSFRVNHPWLGRVTAYDPPRETEKTNNLSV--NWMHTDTCA--EVTDGRTGACLTRTNNSFTP--------SRLCKAALFESFKELC-------------QRTDREDLLHAD---TYSQAKQMAVEFQNAKRELFECFQKSRYGQWV 488          

Query:  423 SARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKK-----KQVTQSSDESPADSYRKIANSKYEELLESFSGSIPK-------------RYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            S + ++  Y + +  A   L+++A+ + + LE  E V + N++   +AF V+I G E+  G G  KK+AR  AA  A+ E+   L  +N N  +P+ ++       K+    SD  P  +  +  +S   ++ ++    + K               AAFII     Q+A    VVA G G     +++ A   G  + +  A+V A+RSL  F Y  +L+   K  +NL  + ++ +   +G ++L+ G  LHLY++  PKG  + S  R    PL +S  +++ +                I L    H+ V     E +  S+ +       ++ V+MS TDKL  W  LG QGALLSH + PVY+ SI  G     +     +     +E I S    +Y  ++     +  V  + +++    Y       NW     +   E++D   G     SP++          SRL K  ML R K           +  E QR   L     A  + Y   K  A  Y+  K  L E LL + YG W+
Sbjct:   64 SPKVLIDKYTQGETHAVSLLHQLAQVLQFHLEIKETVTTGNIQGFYFAFCVVIDGVEYKTGMGITKKEARLKAAQLALPELLPTL--ENLNYVLPEASDVPPPLPVKEEPSISDIHPCRAIHERTSSVNLQIPQAVKDQLTKLMNSHPEFSACAGTTAAFII-----QNAGVFEVVALGTGN--FNTNESASMSGRIVHDSHAVVTARRSLMRFLYRHLLMFFSKT-ANLTKKSIFQQNSSSGLLSLRDGITLHLYVNQLPKGAAIPSKLR--LNPLSISAWQVNNE----------------ISL----HLSV-----EGKVFSVFSSSFDQSPSKMVSMSATDKLTQWQVLGYQGALLSHFIEPVYVQSILIGDIDCSDIRGMTISVSQRVEGITSKLPMFYCMMRPCISLVPSVATSTADKCQLTYG-----INWSEGDSSV--EVVDGLEGKTVEQSPFK----SGPALASRLCKAAMLHRFK----------LVAKEAQRQDLL-----AASF-YKEAKRMAKPYQEAKNVLKEFLLQQGYGSWL 549          

Query:  387 DEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNN--------KKKQVTQSSDESPADSYRKIANSKYEELLES-----------FSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIP-RDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTET--DSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            D   Y   +K+ S + ++  Y+  +  A   L+++A+   + LE  E + S +L+   +AF VLI G E+  G G NKK+AR NAA  A+ E    L++ N +  +PDT +        ++  V  S    P+   +   N +    + +           FSG      AAF+I     Q   E  VVA G G G    ++++ N G  + +  A+V A+RSL  + Y   LL+   K   L  + VY     + ++ LK G  LHLY++  PKG  V  IP + +  PL +S  ++                S  I L    H+ V     E + +S+ +   +N   + V+MS  DK+  W  +G QGALLSH + P+Y  SI  G     E           +E + S    +Y  ++     +  V      SNQ+         C NW     T   E++D   G     SP++          SRL K  ML R K           +  E +R   L          Y   K  A  Y+  K  L   L  K +G W+
Sbjct:   42 DSSQYPVKAKV-SPQKLIERYMNGESDAVSLLHQLARVFQFHLEMKETIASGDLQMLCFAFCVLIDGVEYKTGTGINKKEARLNAAKLALEEFLPSLEQFNLS--LPDTTDVPPPLPLKEESCVGGSCHNRPSYEAKVPVNMQIPHAVRAQLTRLMSFHPEFSG-CADTIAAFVI-----QAGSECKVVALGTG-GFNTRENISSN-GRILHDSHAVVTARRSLMRYLYRN-LLMFYSKNPTLSQQSVYQHKSNSNFLCLKSGISLHLYVNMMPKGAAV--IPSKLYLNPLSISAWKV----------------SNEIGL----HLMV-----EGKLVSVFSSEVENLAFKVVSMSTADKITQWQVIGYQGALLSHFIEPIYAQSILIGDSCCSEVRGMEFSVCQRMEGVTSQLPMFYCMMRPLISLVPSVANCTPSSNQLTH-------CINWSEGDSTL--EVVDGLEGKTVEESPFK----SGTTLASRLCKAAMLHRFK----------LVAKEAERQDLL------VASSYREAKRMAKPYQEAKSVLRAYLCQKGFGSWL 539          

Query:  423 SARYIVSSYLKNQKTAAQALNEIAKAMVWELEFE----PVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFE--VGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISL-VTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHIS--RALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            S + ++  Y++ +  A   L+++A+ + + LE +    P +   L +AF  +I G E+  G G  KK+AR NAA  A+ ++   L  ++    +P+ + +KK V      +  D   K+ NS  E    S +G+I    AAFI+     Q +    VVA G G      + ++ N G  + +  A+V A+RSL  F Y  +L+   K  +NL  + ++ +     +  ++LK G  LHLY++  PKG   + +P+    PL +   +++ +                                    ISL ++   K  L   V+MS TDKL  W  LG QGALLSH + PVY+ SI  G     E  S  R++  RV  E I S    +Y  ++   P++  V    S++ +   +      NW     +   E++D   G    +SP++       +  SRL KV ML R +           +  E QRT  L          Y   K  A  Y+  K  L   L  + +G WV
Sbjct:   60 SPKTLIDRYMRKETNAISLLHQLAQTLQFHLEMKETVTPANVTGLYFAFCAVIDGVEYKTGIGTAKKEARLNAAQLALQDLLPTL--ESLKSGLPEASERKKSVNLQIPHAVRDQLTKLMNSHPE--YSSCAGTI----AAFIL-----QTSSGYEVVALGTGN-FNTKESISSN-GRILHDSHAVVTARRSLMRFLYRHLLMYFSKN-ANLTEKSIFQQNSSSSSSLLSLKSGVTLHLYVNQLPKG-AAQVLPKLRLNPLSMLAWQVNNE------------------------------------ISLHLSVEGKVMLCYMVSMSTTDKLTQWQVLGYQGALLSHFIEPVYVQSILIGDSDCSEICSMERSVSQRV--EGITSELPMFYCMMR---PHISLVPSVASSRADG--NQLTYSVNWSEGDSSL--EVVDGLEGKTIEDSPFK----SGCSLASRLCKVAMLHRFR----------LVAKEAQRTDLL------ATTSYRGAKMMAKSYQESKNILRAYLHQQGFGSWV 514          

Query:  426 ARYIVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKN---LRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHV---PDTNN---------KKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWE-EPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            ++ ++  Y++ +  A   L+++A+ + + LE  E V + N   L +AF V+I G E+  G G  KKDAR  AA  A+ ++   L        V   P  +N         +K  V      +  D   K+ NS  E    + +G+     AAFII     Q +    VVA G G     + + A + G  + +  A+V A+RSL  F Y  +L+   K  +NL  + ++ +   +G ++LK G   HLY++  PKG     IP      PL +S  +++ +                I L    H+ V     E +  S+ +    +  ++ V+MS TDK+  W  LG QGALLSH + P+Y+ SI  G  Y  +     +     +E I S    +Y  ++   P++  V    +N  +S         NW     +   E++D   G     SP++          SRL K  ML R K           +  E QR   L          Y   K  A  Y+  K  L   LL + +G W+
Sbjct:   28 SKTMIDKYMRGETHAVTLLHQLAQILQFSLEMKETVTTGNIPGLYFAFCVVIDGVEYKTGMGITKKDARLKAAQFALQDLLPTLDSVPPPLPVKEEPSISNTYPARAIHERKNSVNLQIPHAVRDQLAKLMNSHLE--FSACAGTT----AAFII-----QTSSGCEVVALGTGN--FNTKESASSSGRIVHDSHAVVTARRSLMRFLYRHLLMFFSKT-ANLTEKSIFQQNSNSGLLSLKSGITFHLYVNQLPKGAA--QIPSKLRLNPLSISAWQVNNE----------------ISL----HLSV-----EGKVFSVFSSGFDHSASKVVSMSTTDKITQWQVLGYQGALLSHFIEPIYVQSILIGDSYSSDIRGMEISVSQRVEGITSQLPMFYCMMR---PHIGLVPSVATNGSDS--GQLTHGINWSEGDSSV--EVVDGLEGKTIEESPFK----SGPALASRLCKAAMLHRFK----------LVAKEAQRQDLL------ATSSYREAKRMAKPYQEAKNVLRAYLLQQGFGSWL 503          

Query:  435 IVSSYLKNQKTAAQALNEIAKAMVWELEF-EPVHSKNLR---YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPA-----------------DSYRKIANSKYEELLESFS--GSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWE-EPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            ++  Y + +  A   L ++++ + +++E  E V +  +    +AF  +I G E+  G G NKK+AR  AA  A+ E+   L     +G +PD+      +     E P                  D         + +L++S+          AAF+      Q +    VVA G G  +   + L  + G  + +  A+V A+RSL  + Y  +LL   K RS L+ + ++ +      ++LK    LHLY++  PKG     IP      PL +S  E++ ++ G                    H+ +     + +  S+ +   +   +  V+MS TDK+  W  LG QGALLSH + P+Y+ SI  G +   +     +     ++ I S    YY   +     +  V  TD++             NW    V+   E++D   G     SP++          SRL K  ML R          +  +  E QR   L  ++      Y   K  A  Y+  K  L   L  + YG+WV
Sbjct:   71 LIERYKRGETHAVSLLYQLSQVLQFQVEMKETVTTGGITGFYFAFCAVIDGVEYKTGMGVNKKEARAKAAQLALEEL---LPVLENDGVLPDSLVGPPPLPVKEREYPLSETHFGRTVFERKNPVKDQIPSTIKEMFSKLMDSYPEFAGCGGTVAAFV-----TQTSIGCEVVALGTGN-LNTKESLTPS-GRILHDSHAVVTARRSLMRYLYRHLLLFFSKNRS-LEEKSIFQQDQNTKLLSLKSHITLHLYLNQLPKG--AAQIPSHLRLNPLSISAWEVN-NQIGL-------------------HVMI-----DGKVFSVFSSTFEQCGSHVVSMSATDKITQWQVLGFQGALLSHFIEPIYVSSILIGDESCSDTRGMEVAINQRVDGITSKLPMYYCVYRPHISLVPSVMATDAHSTQRTLS-----LNWSQGDVSL--EVVDSLDGKTVEESPFK----SGPALASRLCKAAMLSR----------FNLVSKEAQREELLTAVS------YREAKMMAKPYQEAKSVLKSYLATRGYGQWV 553          

Query:  546 RYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSI-PKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGD-------CVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSK-------ACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESI--NAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            R+ +   + G  F      NKK  +Q AA  A+  +    ++  R G +      +  V+ S+     D    +++ ++  L      S+  ++  A II  R D     G+VV+ G G    K ++L+  +G  + +  A +I++R    F Y++++     K  +   E   FEV ++  + +K     HLY+S AP GD       C ES        + L     +  + GKL         +  +    G I V     E   I + T+       R  TMS +DK++ W  LG+QGALLSH ++PVYL SI  G  Y H H++RA+ CR     +  + G + +S+    P    +T  +  ++ SVYD+++       +  NW + P     E++D   G V               + SR+SK  +    +E    +   D  A+ P Y                    K  A  +++ K   F++L  + YG W+
Sbjct:  915 RFTYQAKLGGRWFPAVCASNKKQGKQEAADAALRVLIGEAEKAARTGEL----TPELPVSGSTLH---DQLAMLSHQRFNALTARIQHSLLGRKILATIIMRRGDDSL--GTVVSLGTGNRCVKGEELSL-KGDTVNDCHAEIISRRGFIRFLYSELI-----KHWDGPAEDSIFEVAEDNKLKIKSDTTFHLYISTAPCGDGALFDKSCSESAEVTGASHMPL----FENAKQGKL---------RTKVENGEGTIPV-----ESSAI-VPTWDGIQHGERLRTMSCSDKILRWNVLGLQGALLSHFLHPVYLSSITLGYLYSHGHLTRAVCCR-----LTRDGGEFAKSL----PPNFTLTHPEVGRV-SVYDSTRHTGKTKESSVNWSL-PDKLTVEVLDGTKGKVD----------SAKLEVSRVSKSNLYRLFREVCRRSGRADLLAL-PSYAHA-----------------KMGAASFQQAKALFFQALGQQGYGAWI 1345          

Query:  747 ADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVP-LENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRL-SKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            AD+  ++   K+ EL ++F+    +R   A  ++T   D   KE  V+    G      + +++ RG  + +  A +IA+RSL  + Y Q+   L   +   +   ++    K+GY  LK   + HLY+S +P GD     P +     +   +  +R   G+L         +  +    G I V   ++   W  ++      +  R +TMS +DK+  W  +GIQG+L+S+   P+Y  SI  G  Y  +H+SRA+  R+  +E++        +      P L  ++  ++ Q     + S    NW +    +  E+I+  TG      P  L     +++  RL SK+   LR+K S          +P                  Y+  K +AV+Y   KQ L ++      G WV   IE+++F+L
Sbjct:  322 ADAVSRLVVDKFSELTDNFTSPHARRKVLAGVVMTTGTD--VKEAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIIARRSLIRYLYMQLEFFLSNNKEEHQ-NSIFTRCEKHGY-RLKDNVQFHLYISTSPCGDARIFSPHEAGVEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSNTIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLMSYFTEPIYFSSIILGSLYHADHLSRAMYQRIADIEDLP-------QQFTLNRPLLSGISNAEARQPGKAPNFS---VNWTI--ADQGLEVINATTGKDDMGRPSRLCKHALYSRWVRLHSKLSSTLRIKMS----------KPS----------------SYHEAKQAAVEYHSAKQTLIKAFQKAGLGAWVKKPIEQDQFSL 697          

Query:  747 ADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVP-LENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRL-SKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            AD+  ++   K+ EL ++F+    +R   A  ++T   D   KE  V+    G      + +++ RG  + +  A +IA+RSL  + Y Q+   L   +   +   ++    K+GY  LK   + HLY+S +P GD     P +     +   +  +R   G+L         +  +    G I V   ++   W  ++      +  R +TMS +DK+  W  +GIQG+L+S+   P+Y  SI  G  Y  +H+SRA+  R+  +E++        +      P L  ++  ++ Q     + S    NW +    +  E+I+  TG      P  L     +++  RL SK+   LR+K S          +P                  Y+  K +AV+Y   KQ L ++      G WV   IE+++F+L
Sbjct:  378 ADAVSRLVVDKFSELTDNFTSPHARRKVLAGVVMTTGTD--VKEAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIIARRSLIRYLYMQLEFFLSNNKEEHQ-NSIFTRCEKHGY-RLKDNVQFHLYISTSPCGDARIFSPHEAGVEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSNTIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLMSYFTEPIYFSSIILGSLYHADHLSRAMYQRIADIEDLP-------QQFTLNRPLLSGISNAEARQPGKAPNFS---VNWTI--ADQGLEVINATTGKDDMGRPSRLCKHALYSRWVRLHSKLSSTLRIKMS----------KPS----------------SYHEAKQAAVEYHSAKQTLIKAFQKAGLGAWVKKPIEQDQFSL 753          

Query:  435 IVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLLE 2042
            + +  + + K A   LNE+   + +E   E   S    +  AV +    F  G G NKK A+  AA  A+S +  ++L +      +P     +  +     +  AD+  ++   K+ EL ++F+    +R   A  ++T   D   K+  V+    G      + +++ RG  + +  A +I +RSL  F Y+Q+   L     +     V+ +   +GY  LK   + HLY+S +P GD     P +     +   +  +R   G+L         +  +    G I V   ++   W  ++      +  R +TMS +DK+  W  +G+QG+L+S+   P+Y  SI  G  Y  +H+SRA+  R+      S+     +      P L  ++  ++ Q     + S    NW +    +  E+I+  T            G D+  + S L K  +  R          +  +  +  +T  ++G   A    Y+  K  A++Y   KQ L ++      G WV   IE+++F+L +
Sbjct:  218 LTAPPIGHGKNAVMILNELRPGLKYEFVAESGESHAKNFVMAVTVDTQVFQ-GSGRNKKLAKARAAQAALSGLFNMQLDQTPSRQPIP-----RDGLQLHLPQVLADAVSRLVVEKFSELTDNFTSPHARRKVLAGVVMTTGTD--VKDAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIITRRSLIRFLYSQLEYFLSNNPED-HARSVFRQCETHGY-QLKESVQFHLYISTSPCGDARIFSPHEAAVEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRTSNTIQTWDGVL------QGERLLTMSCSDKIARWNVVGVQGSLMSYFSGPIYFSSIILGSLYHADHLSRAMYQRI------SDIEELPQPFNLNRPLLSGISNAEARQPGKAPNFS---VNWTVG--DQGLEVINATT------------GKDDLGRPSHLCKHALYSR----------WVRLNTKLSQTLRIRGDQPAT---YHEAKQGAMEYHTAKQTLIKAFQKGGLGAWVKKPIEQDQFSLTQ 694          

Query:  480 LNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCML---LRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            LNE+   + ++   E   S    +  AV + G  F  G G NKK A+  AA +A+ +    L+     G  P  +   + +     +  AD+   +   K+ +L E F+    +R   A  ++T   D   K+  V++   G      + +++ RG  + +  A ++A+R+L  + Y Q+ L     +   K   ++  + + G+  LK   + HLY+S +P GD     P +    +    K  +R   G+L   +  S    I ++  G ++              T+    +  R +TMS +DK+  W  LGIQG+LLSHLM P+YL S+  G  Y  EH+SRA   R+      S+        K   P L  ++  +S Q       S    NW     +   E+I+  T            G ++  + SRLSK  +    LR+   +N  ID    R           +N  C+      K +A DY+  K+ L  +      G W+   IE+++F+L
Sbjct:  245 LNEMRPGLRFDFVAEIGESHARNFVMAVTVDGQTFQ-GFGRNKKLAKARAA-QAVLQGIFNLQLDATPGRQPIPS---EGLQLHLPQVLADTVASLVQQKFSDLTEGFTSPHARRKVLAGIVMTAGLD--VKDAQVISVATGTKCINGEYMSD-RGLALNDCHAEIVARRALLRYLYTQLELHFSSSKEEEKQTSIFVALEQGGF-KLKEDIQFHLYISTSPCGDARIFSPHEASMDVNAGDKHPNRKARGQLRTKIE-SGEGTIPVRASGAVQ--------------TWDGVLQGERLLTMSCSDKIAWWNVLGIQGSLLSHLMKPIYLNSVILGSLYHGEHLSRAAYQRI------SDIWDLPSPYKLNRPMLSGISNAESRQAGKAPSFSA---NWSYGDGSL--EVINATT------------GKNDLGRASRLSKHALFSRWLRVNRKLNTRIDLKGKR-----------MNVYCEA-----KLAAEDYQGAKRQLNRAFHKASLGAWMKKPIEQDQFSL 706          

Query: 1095 LKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRL-STKEIDRDRCGKLEPIMYMSYSQNILLKEPGH-----IRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV 1529
            L+ G RLHLY+S AP GD             RL ST+E + +  G        +  Q     E G       R L P + D  +      A         M+ +DK+  W  LG+QGALLS L+ P+YL+ +  G  Y  +H+ RA+  RV
Sbjct:    3 LRPGWRLHLYVSTAPCGDA------------RLFSTQEREGNAVGADRHPRRRARGQLRTKLECGEGTVPARRCLEPQTWDGVLQGEPLLA---------MACSDKIARWNVLGVQGALLSRLLEPIYLHGLVLGSLYRPQHLWRAVCTRV 132          

Query: 1329 SLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRL-----SKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            ++ TY     + R  ++  + +L  W  +GIQG+LLSH ++P+YL SI  G  Y  EH+SRA+  R+      ++ G      K   P L  ++  +S Q       S    NW +   +   E+++  TG      P  L       +  RL     S+ C+  R+            ++PE                 Y+  K    DY+  KQ L  S      G W+   IE+++F +
Sbjct:  113 AIQTYHGSPVVFRLGSVPWSTRLCRWNVVGIQGSLLSHYVDPIYLDSIILGSLYHGEHLSRAVCQRM------ADVGELPPLFKLNRPLLSGISNAESRQPGKAPSFS---VNWTVGDHSL--EVVNATTGKDDTGRPSRLAKNAFFTRWVRLYGKVGSRACLKSRV-----------PLKPERPTL-------------YSMAKLEVGDYQLAKQQLDLSFQGAGLGAWIKKPIEQDQFTV 319          

Query:  444 SYLKNQKTAAQALNEIAKAMVWELEFEPVH-SKNL-RYAFAVL--ISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKK----QVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAK---EGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGY-VTLKHGCRLHLYMSHAPKGDCVESIPRD-WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTG-CVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            +Y    K    ALNE A+    E+ FE V   +N  R  F +   +  + F      N KDAR+ AA  A+  I      Q+ +G  P +   K+    Q +  S       +  IA   +   L+  + SIP ++A   +       A     G VV+ GAG        L+   G  + +  A +IA+RSL  FFY Q+        ++  G+K  FE   N   + ++ G   HLY+S AP GD     PR+     L  S  E       KL+ I+             G I V   D    W  LV      +  R  TMS +DK+  W  LG+QGALLSH + PVYL S+  G  Y H H++RA+ CR  L++          S +   P+L RVT  D  +     +N     NW         E+ D RTG C+   +    P        SRL K  +    KE               QRT     ++      Y+  K  AV+++  K+ LFE      YG+WV
Sbjct:    8 AYAAINKNPVSALNEYAQKNRMEVAFEVVKDGRNFNRPPFTMFARVGPHRFPSATSSNMKDARREAADMALRAIV----GQSASGSGPTSGRSKEVFLSQPSPGSLSGVRTHFDLIAALAHHAFLQ-IAASIPDKFAGRKVVACIIMKASLEDSGRVVSLGAGNRCVTGQRLSME-GKVVNDSHAEIIARRSLLRFFYAQL-------HAHFDGQKSIFEKRNNSRRLAVRQGVSFHLYISTAPCGDGALFTPREGLNTDLSESKMEHKPAFTSKLQGILRTKIEDG-----EGTIPVDPSDGPQTWDGLV------QGGRLRTMSCSDKICRWNALGLQGALLSHFIEPVYLESLTLGYLYDHGHLARAVCCR--LQHKVDLGAELTGSFRVNHPWLGRVTAYDPPRETEKTNNLSV--NWMHTDTCA--EVTDGRTGACLTRTNNSFTP--------SRLCKAALFESFKELC-------------QRTDREDLLHAD---TYSQAKQMAVEFQNAKRELFECFQKSRYGQWV 488          

Query:  480 LNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNR--------NGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVR-KSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNLL 2039
            LNE+    + + +FE   S++ ++   + ++G EF+ G G +KK A+  AA +A++++  ++   +         NG  P    ++   TQ   E  AD    I   KY+ L  +   +  ++  A I+  R  Q   +        G G +  S +   ++GY + +    +IA+R L+ F YNQ+ L +   +++       FE+  +G   LK     HLY+S +P GD     P + +       +EIDR    K   I+ +           G I V   DS     ++ T+       +  TMS +DK+  W  LG+QGALLSH + PVY  SI  G  Y + H++RA+  RV P+E++    G Y    +   P + +V+  +S        +S    NW  +   ++ E I+  TG +            E  + SRL K  M  +          + A+  + ++++    +       Y+  K SA  Y++ K  L  + +N   G W+   +E+++F L+
Sbjct:  115 LNELHPTQI-DYQFEEGTSEHDKFICNIELNGVEFS-GTGTSKKKAKVVAATKALAKVYGKVNAFDSCVVPGISTNGSTPTA--QQPPATQLPQEV-ADHIAHIVVEKYQSLTSTLGDAAKRKVLAGIVMVRGSQAGGQARFDMISIGTGTKFISGEYISDKGYAVNDCHGEIIARRGLRKFLYNQLELCVQGDQNS-----SIFELKPSGLYGLKDQVEFHLYISTSPCGDARVFSPHEGDP------EEIDRHANSKKRGILRVKIENG-----EGTIPVANCDS-----AIQTWDGVIGTEKLRTMSCSDKICKWNTLGVQGALLSHFIEPVYFTSIILGSLYRYNHMARAMYERVGPVEDL---PGIY----RCHQPLMNKVSFPESRIPGKAPKHS---LNWLCD--EDIIENINAVTGKL-----------TEAAQPSRLCKQAMFTK----------FLALWAKLRQSQTPPRL-------YDEAKLSAEAYQKAKASLMMAFINNGLGVWIRKPLEQDQFGLV 579          

Query: 1239 IMYMSYSQNILLKEPGHIR-VLRPDSEDEWISLVTYRAKNKLNRHVTMSP----------TDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLE--RVTETDSNQ-INSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKC-SRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEW 2003
            + ++    N+L ++P   + +  P  + + I L   R   K + +++ +P          +DKL  W  LG+QGALLS+L+ P+YL S+  G  +   H++RA+  R+  E +           +   P ++  R+   DS + + +         NW +    +  E++D    C+         G D +N+  SRLSK+ +           ++      EY++    +         Y   K  A DY   K   F+ +    YG+W
Sbjct:   91 VRFLLSQLNLLFEKPSESKSIFLPKIKGQQIKL---REDVKFSLYISTAPCGDALRTASCSDKLAKWNVLGLQGALLSNLIEPIYLNSLVVGNLFEASHLTRAVSARIEREAVKPLSSRLPSPYRVNLPKIQCGRLAPVDSPRDVETKSKTKNLTLNWCLGD-EKRAEVLD---ACL---------GRDPNNRVPSRLSKMAIYANF-------LEVAKKNSEYKKVVEAK--------SYRKAKDQASDYLNAKNTFFQHMKEAQYGDW 329          

Query:  747 ADSYRKIANSKYEELLESFSGSIP--KRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGY-VTLKHGCRLHLYMSHAPKGDCVESIPRD------WEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV-PLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            ADS  ++   K+ +L  S++   P  KR A   +    D+  ++  V+    G      + L+E+ G  + +  A V+A+R L  F Y+Q+ L L +   +   ++  F  G+ G    LK   + HLY+S +P GD     P D       +EPL   T+ + R +    E  + + +      KEP                L T+ A  + +R +TMS +DK+  W  LG QG+L+S+   P+Y  SI  G  Y   H+SRA+  R+ PLE +               P L  ++  ++ Q       S+   NW      +  E+ID  TG      P  L        C R +  C  ++L   +++ +   A  P                  Y+  K +A +Y   K  L+ +L +   G WV    E+++F+L
Sbjct:  266 ADSVSRLILQKFSQL--SYNCKCPHAKRKALAGVVMTTDEGVEQARVICISTGTQCIDGEHLSED-GLTVNDCHAEVVARRCLVRFLYSQLELFLSEDEEH--HQQSIFRRGECGRGFRLKDKVQFHLYVSASPCGDACIFSPHDTGVEGSGDEPLSRRTRGVLRTKVQTGEGTVPVPW------KEP----------------LQTWDALRRGDRLLTMSCSDKMARWNVLGFQGSLMSYFTEPLYFSSIIVGSLYHAAHMSRAMYGRIGPLEGLPPG-------FCLNRPLLSGISNPEARQPARAPPFSE---NWTAG--DDDVEVIDSTTGKEEMGGPSRL--------CKR-AFYCRWMQLHSRLSSFLRVSAPPPS----------------SYHQAKRAAEEYCSAKHTLYRALADAGLGIWVKKPAEQDRFSL 642          

Query:  468 AAQALNEIAKAMVWELEFE------PVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCV---ESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSK---VCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWV 2006
            A   L E A+A  +  E        P H    ++ +   + G  F      NKK  +Q AA  A+  +    +R  R G +  +          S  +  D    +++ ++  L       +  R     I  R  +    G+VV+ G G    K ++L+  +G  + +  A +I++R    F YN++L   D    ++      FE      + LK     HLY+S AP GD     +S     +E ++  +   +  + GKL         +  +    G I V   D    W  +          R  TMS +DK++ W  LG+QGALL+H ++P+YL SI  G  Y H H++RA+ CR+  +   +   S         P + RV+  DS +        ++  NW + P     E++D   G +  N              SR+SK    C+   + +  N A D  ++ P Y +                  K SA  ++  KQ  F++L    YG W+
Sbjct:  836 AVSGLLEYARARGFAAEIRLVGQSGPPHEP--KFTYQAKLGGRWFPPVCASNKKQGKQEAADAALRVLIGEAERAARTGELIPSE------LPVSGSTLHDQIAMLSHQRFNALTTRIQHCLLGRKILATIVMRRGEGL--GTVVSLGTGNRCVKGEELSL-KGETVNDCHAEIISRRGFIRFLYNELLKYYDGADDSI------FEPADGNKLQLKSDITFHLYISTAPCGDGALFDKSCSETGDE-VQGHSPLFENIKQGKL---------RTKVENGEGTIPVESSDIVPTWDGI------QHGERLRTMSCSDKILRWNVLGLQGALLTHFLHPIYLKSITLGYLYSHGHLTRAVCCRLARDG-EAFAQSLPHPFTLNHPEVGRVSVYDSTR--HTGKTKESSVNWSL-PDQYNVEVLDGTKGKLDGNK----------QSVSRVSKSRLFCLFRSMCQKSNRA-DLLSL-PSYAQA-----------------KISATSFQLAKQHFFQALSVHGYGAWI 1294          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLR-YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKAC--FNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYD----YNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEI 2045
            K     LNE+   + +    E    + LR +  AV + G  F  G G +KK A+  AA  A+  +  IRL  + R G      ++K  +    D   ADS   +   KY  L+   S +  +  +   I    D   +   VVA   G      + L++ +G  + +  A V A+R+L  F Y+Q+ L L K+  + + E ++    +  Y  L+     HLY+S +P GD   + P +    L  S   + + RC     I     +     + P                + T+    +  + +TMS TDKL  W  LG+QGALLSH + PVYL+S+  G      H+SR L  R          G    S +   P L  ++  +  Q         AC   NW +  V    E+++  TG              +    SRL K  +  R                 + R     GI+ +   D    Y   K +A  Y+  KQ  F SL     G WV      +  LL I
Sbjct:  299 KGPVAMLNELRPGLRYACLSERAEGRRLRNFVMAVRVDGRIFE-GCGRSKKLAKTQAAQCALQALFNIRLAPEGRTGL---KVSRKSCLHLPQDF--ADSVFYLVKEKYRLLVGGCSPAHTRHKSLAGIVMTRDLDLRRAQVVALSTGTKCINGEYLSD-QGQVVNDCHAEVTARRALLRFLYSQLELFLSKRMEDWE-ESIFVRHKERSY-RLRDDVHFHLYISTSPCGDGRLNSPYEISTDLHSSRHLMRKHRCHLRTKIESGEGTVPARCRGP----------------VQTWDGVLQGEQLITMSCTDKLTRWNILGLQGALLSHFVEPVYLHSVTVGSLRHTGHLSRVLSQR------QERLGPLPVSYRRNQPLLSGLSSAEYQQ-----PGKAACVSVNWTVGDVQL--EVVNTVTGRRR-----------DSGAPSRLCKHALFTR-----------------WSRLYRKLGIHASGSADGQLMYYEAKMAARPYQTAKQQWFRSLQETGLGTWVKKPPEQEHFLLSI 768          

Query:  462 KTAAQALNEIAKAMVWELEFEPVHSKNLR-YAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI-KIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRAL 1517
            K     LNE+   + +    E    + LR +  AV + G  F  G G +KK A+  AA  A+  +  IRL  + R G      ++K  +    D   ADS   +   KY  L+   S +  +  +   I    D   +   VVA   G      + L++ +G  + +  A V A+R+L  F Y+Q+ L L K+  + + E ++    +  Y  L+     HLY+S +P GD   + P +    L  S   + + RC     I     +     + P                + T+    +  + +TMS TDKL  W  LG+QGALLSH + PVYL+S+  G      H+SR L
Sbjct:  325 KGPVAMLNELRPGLRYACLSERAEGRRLRNFVMAVRVDGRIFE-GCGRSKKLAKTQAAQCALQALFNIRLAPEGRTGL---KVSRKSCLHLPQDF--ADSVFYLVKEKYRLLVGGCSPAHTRHKSLAGIVMTRDLDLRRAQVVALSTGTKCINGEYLSD-QGQVVNDCHAEVTARRALLRFLYSQLELFLSKRMEDWE-ESIFVRHKERSY-RLRDDVHFHLYISTSPCGDGRLNSPYEISTDLHSSRHLMRKHRCHLRTKIESGEGTVPARCRGP----------------VQTWDGVLQGEQLITMSCTDKLTRWNILGLQGALLSHFVEPVYLHSVTVGSLRHTGHLSRVL 653          

Query:  747 ADSYRKIANSKYEELLESFSGSIPKR--YAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVP-LENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCM---LLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            AD+  ++   K+ EL ++F+    +R   A  ++T   D   KE  V+    G      + +++ RG  + +  A +IA+RSL  + Y Q+   L   +   + +K  F   + G   LK   + HLY+S +P GD     P +     +   +  +R   G+L         +  +    G I V   ++   W  ++      +  R +TMS +DK+  W  +GIQG+L+S+   P+Y  SI  G  Y  +H+SRA+  R+  +E++        +      P L  ++  ++ Q     + S    NW +    +  E+I+  T            G D+  + SRL K  +    +RL   +++ +     +P                  Y+  K +A +Y   K+ L ++      G WV   IE+++F L
Sbjct:  318 ADAVSRLVVDKFSELTDNFTSPHARRKVLAGVVMTTGTD--VKEAQVICVSTGTKCINGEYMSD-RGLALNDCHAEIIARRSLIRYLYTQLEFFLSNNKE--EQQKSIFVTCERGGYRLKDNVQFHLYISTSPCGDARIFSPHEAGVEDQ-GDRHPNRKARGQL---------RTKIESGEGTIPVRSSNTIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLMSYFTEPIYFSSIILGSLYHADHLSRAMYQRIADIEDLP-------QPFSLNRPLLSGISNAEARQPGKAPNFS---VNWTVG--DQALEVINATT------------GKDDMGRASRLCKHTLYSRWVRLHCKLSSILRIKVPKPS----------------SYHDAKQAATEYHSAKKALIKAFHKAGLGAWVKKPIEQDQFPL 693          

Query:   33 MSYTCSYCKTGVMNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI 2054
            MSYTCSYCKTGVMNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGH+PDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI
Sbjct:    1 MSYTCSYCKTGVMNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHIPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI 674          

Query:   69 MNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHVPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI 2054
            MNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGH+PDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI
Sbjct:    1 MNTPEQYQTHINGSKHKKKAFQLQAPDGGIEYDEFKPSKTVKNAAPFEEKAEDFPTLTNETLSNGNNILAYSNIKNSLCSGNRPIVVYEDPVNHEDCIEEDDFRTVDEVFYNENSKIESARYIVSSYLKNQKTAAQALNEIAKAMVWELEFEPVHSKNLRYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEIKIRLKRQNRNGHIPDTNNKKKQVTQSSDESPADSYRKIANSKYEELLESFSGSIPKRYAAFIITERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLKGEKVYFEVGKNGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPNIERNKFNLLEIYDI 662          

Query:  546 RYAFAVLISGNEFAVGEGENKKDARQNAAAEAISEI------KIRLKRQNRNGHVPDTNNKK--KQVTQSSDESPADSYRKIANSKYEELLESFSGSIP---------KRYAAFII-TERYDQHAKEGSVVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSNLK-GEKVYFEVGK-NGYVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNIL-LKEPGHIRVLRPDSEDEWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENINSNRGSYYESIKYFDPYLERVTETDSNQINSVYDNSKACFNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKF 2030
            R + AV ++G +F      NKK+ ++ AA  AI  +        ++K  ++    PD+ N++  K   +  D++    Y  + +  Y +L E  +   P         K  AA ++  E+Y+       VV+   G      D L+  +G  I +  A V+A+RSL  F Y Q+   L    ++L   E+++ +    + Y  +K+  + HLY+S AP GD     P++  + ++ +   +  D     EPI + + SQ +L  K  G    +     ++     T     +  R  TMS +DK+  W +LG+QGALLS  M P++L S+  G  +   H+SRA+ CR  LE  + +  S   +I +  P L  V   + N+   +  +++   NW      E  E++D  TG +   S   +      ++ ++ S  C  L++                 QR R+   +       YN  K+ +  Y   K+ L+       YG WV   +E+++F
Sbjct:  118 RISTAVFLNGKQFDTAITLNKKEGKRKAADLAIRSLISEGHFSTKIKEFSKLSTSPDSFNRQFSKTNKEKIDDNSPMIYNHMVSLVYNKLAEIINQLSPNQGLSLAGRKIVAAIVMQNEKYENF----EVVSLATGNRCITGDKLSL-QGSVINDCHAEVVARRSLMYFLYKQLNAFLSDSSNSLDLFEEIHTQNAIFSRYFQIKNHIKFHLYISTAPCGDSALFCPKETTDKVQETHVVLSEDH----EPI-FENNSQGLLRTKIEGGEGTIPVQVHEDCNRAQTLDGILQGERLRTMSCSDKIARWNYLGVQGALLSFFMKPIFLKSLMLGNLFNAGHLSRAVCCR--LEKFSVSPLSGKCNINH--PDLVNVFIGEFNR--EIDKSNELSINWCHG---ETAELVDGVTGELSMKSKTNIV----RSRLAKASLFCEFLKV----------------CQRLRFPTQL---ATMQYNEVKSLSRFYDDQKKTLYLRFHCAKYGSWVCKPLEQSQF 592          

Query:  879 VVAFGAGKGVRKSDDLAENRGYDIKNFDALVIAKRSLQCFFYNQILLLLDKKRSN----LKGEKVYFEVGKNG---YVTLKHGCRLHLYMSHAPKGDCVESIPRDWEEPLRLSTKEIDRDRCGKLEPIMYMSYSQNILLKEPGHIRVLRPDSED----EWISLVTYRAKNKLNRHVTMSPTDKLMSWIHLGIQGALLSHLM-NPVYLYSIQFGKDYMHEHISRALLCRV-----PLENINSNRGSYYESIKYFDPYLERVTET-DSNQIN-----SVYDNSKAC--------FNWYMNPVTELPEIIDVRTGCVHHNSPYELPGGDEHNKCSRLSKVCMLLRLKESINAAIDYFAMRPEYQRTRYLQGINGACKYDYNSFKTSAVDYRRLKQCLFESLLNKHYGEWVPN-IERNKFNL 2036
            ++   +G      +++ +N G  + +  A +++KR+ Q F Y  I  L    ++     L G  + +   K G      LK   R+HLY+S AP GD    +P    + L  S  E   +       +   +   +   K  G +R      E     +   L T+       R +TMS +DK+ +W  LGIQGALLS+++ NP+YL SI  G  + HEH+ RAL  R        E IN N   Y E  +  +  L+ V +T DS Q+N     +V +    C         NW +   +   EII    G    N+P  L    + N  S+   V   L L  + +    Y+    +Y   + L  +          +   A++Y++ K  LF+    +++G W+   IE++ F +
Sbjct:  329 LITISSGTKCLSGNEINDN-GLVVNDCHAEIVSKRAFQYFLYQSIGRLQRDIQAEFDDELYGCDILYPFDKGGQQMVYKLKEDVRIHLYVSSAPCGDSRIFMP----QSLNSSIAEELEEEPAAASALDDGNEDSHPNRKNRGVLRTKIECGEGTIPIKTKFLQTWDGILGGERLLTMSCSDKVCTWNVLGIQGALLSNVLCNPIYLDSITIGSIFHHEHLVRALCDRARGVTEEPEWINGN-AIYTEECEQGE--LQIVLDTNDSFQVNKPFILTVSNQDDRCPGKASNFSINWILGEQSY--EIISTAKGVTLTNTPSRLC---KRNLLSKFLSVFNWLPLISAGSGDSGYY----QYGAIKSLGNV--------PDYAIGALNYQKKKISLFKYFDKQNFGLWIGKPIEQDWFTV 721