Cyclin-dependent kinases regulatory subunit

Overview


Name	Cyclin-dependent kinases regulatory subunit
Smed ID	SMED30015678
Length (bp)	519

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cyclin-dependent kinases regulatory subunit (SMED30015678) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinases regulatory subunit (SMED30015678) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinases regulatory subunit (SMED30015678) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30015678

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
X1 cell	SMED30015678	SmedASXL_028678	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30015678	SmedASXL_028678	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30015678	dd_Smed_v4_6668_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30015678	dd_Smed_v6_6668_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
parenchyma	SMED30015678	Contig44265	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
parenchyma	SMED30015678	Contig44265	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
head region	SMED30015678	OX_Smed_1.0.17435	ox_Smed_v2	PMID:24238224 Kao et al., 2013
zeta neoblast	SMED30015678	dd_Smed_v4_6668_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
neoblast	SMED30015678	SMED_24896_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30015678	SMED_24896_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30015678	SMED_09394_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30015678	SMED_09394_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS2 (CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000])

HSP 1 Score: 116.701 bits (291), Expect = 4.457e-34
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 115.931 bits (289), Expect = 6.671e-34
Identity = 53/72 (73.61%), Postives = 61/72 (84.72%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 97.0561 bits (240), Expect = 1.499e-26
Identity = 45/62 (72.58%), Postives = 51/62 (82.26%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEP 236
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEP 62

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 89.7373 bits (221), Expect = 8.784e-24
Identity = 40/53 (75.47%), Postives = 46/53 (86.79%), Query Frame = 3

Query:  108 RHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            RHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    4 RHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 56

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Match: cks-1 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:Q17868])

HSP 1 Score: 110.153 bits (274), Expect = 8.309e-32
Identity = 48/69 (69.57%), Postives = 58/69 (84.06%), Query Frame = 3

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             + YYS+KY DD +EYRHVH+  D++KL+PK RLMSE EWRS+GIQQS GW+HYMIH PE HV+LFRRP
Sbjct:    6 NDFYYSNKYEDDEFEYRHVHVTKDVSKLIPKNRLMSETEWRSLGIQQSPGWMHYMIHGPERHVLLFRRP 74

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Match: Y71G12B.27 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:Q95XM4])

HSP 1 Score: 100.908 bits (250), Expect = 8.148e-28
Identity = 46/84 (54.76%), Postives = 62/84 (73.81%), Query Frame = 3

Query:   57 VKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPR--TEGDQNAVETE 302
            +++IYYS +Y DD YEYRHV LP  +++ VPK RL+SE EWR  G+QQS+GW HYM+H PE H++LFRR R  T+ D+   + E
Sbjct:    1 MEDIYYSPRYEDDEYEYRHVILPQAVSRKVPKGRLLSEAEWRRAGVQQSLGWEHYMVHNPEKHILLFRRKRHFTKADEERAKME 84

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks30A (gene:FBgn0010314 transcript:FBtr0079799)

HSP 1 Score: 117.087 bits (292), Expect = 9.749e-35
Identity = 51/72 (70.83%), Postives = 64/72 (88.89%), Query Frame = 3

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE 275
            K+IYYSDKYYD+ +EYRHV LP +L K+VPK  LM+E EWRSIG+QQS GW+HYMIH+PEPH++LFRRP+T+
Sbjct:    3 KDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD 74

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0337074)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0081949)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0305339)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks1b (CDC28 protein kinase regulatory subunit 1B [Source:ZFIN;Acc:ZDB-GENE-040801-112])

HSP 1 Score: 114.39 bits (285), Expect = 2.400e-33
Identity = 52/72 (72.22%), Postives = 60/72 (83.33%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP D+ K VPK  LMSE EWR++G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDDKFEYRHVMLPKDIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: zgc:86839 (zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102])

HSP 1 Score: 113.235 bits (282), Expect = 4.648e-33
Identity = 53/72 (73.61%), Postives = 60/72 (83.33%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYTDDHFEYRHVVLPRELAKQVPKSHLMSEDEWRRLGVQQSLGWVHYMIHEPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:ZFIN;Acc:ZDB-GENE-050208-508])

HSP 1 Score: 110.923 bits (276), Expect = 4.614e-32
Identity = 49/69 (71.01%), Postives = 57/69 (82.61%), Query Frame = 3

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74

[Close]

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74

[Close]

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:NCBI gene;Acc:548924])

HSP 1 Score: 120.168 bits (300), Expect = 1.807e-35
Identity = 55/79 (69.62%), Postives = 63/79 (79.75%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            MS KNIYYSDKY D+ YEYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MSFKNIYYSDKYSDENYEYRHVMLPKELAKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Match: ehd1 (EH domain containing 1 [Source:Xenbase;Acc:XB-GENE-490186])

HSP 1 Score: 119.398 bits (298), Expect = 2.777e-35
Identity = 53/72 (73.61%), Postives = 62/72 (86.11%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS KNIYYSDKY D++YEYRHV LP D  K+VPK  L+SE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSAKNIYYSDKYDDELYEYRHVMLPKDFAKMVPKTHLISESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks2 (CDC28 protein kinase regulatory subunit 2 [Source:MGI Symbol;Acc:MGI:1913447])

HSP 1 Score: 116.701 bits (291), Expect = 2.898e-34
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1b (CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208])

HSP 1 Score: 115.931 bits (289), Expect = 4.580e-34
Identity = 53/72 (73.61%), Postives = 61/72 (84.72%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1brt (CDC28 protein kinase 1b, retrogene [Source:MGI Symbol;Acc:MGI:3643620])

HSP 1 Score: 106.686 bits (265), Expect = 4.461e-30
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR +G+QQS GWVHYMIHEPE H++LF+ P
Sbjct:   18 MSHKQIYYSDKYDDEEFEYRHVMLPKDIDKLVPKTHLMSESEWRKLGVQQSQGWVHYMIHEPELHILLFQWP 89

[Close]

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR +G+QQS GWVHYMIHEPE H++LF+ P
Sbjct:   18 MSHKQIYYSDKYDDEEFEYRHVMLPKDIDKLVPKTHLMSESEWRKLGVQQSQGWVHYMIHEPELHILLFQWP 89

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1b (CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208])

HSP 1 Score: 84.7297 bits (208), Expect = 4.398e-22
Identity = 37/49 (75.51%), Postives = 43/49 (87.76%), Query Frame = 3

Query:  120 LPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    2 LPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 50

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q91879|CKS2_XENLA (Cyclin-dependent kinases regulatory subunit 2 OS=Xenopus laevis OX=8355 GN=cks2 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 5.979e-34
Identity = 54/79 (68.35%), Postives = 63/79 (79.75%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            MS KNIYYSDKY D+ +EYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MSYKNIYYSDKYTDEHFEYRHVMLPKELAKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q24152|CKS1_DROME (Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks30A PE=3 SV=1)

HSP 1 Score: 117.087 bits (292), Expect = 9.772e-34
Identity = 51/72 (70.83%), Postives = 64/72 (88.89%), Query Frame = 3

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE 275
            K+IYYSDKYYD+ +EYRHV LP +L K+VPK  LM+E EWRSIG+QQS GW+HYMIH+PEPH++LFRRP+T+
Sbjct:    3 KDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD 74

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q25330|CKS1_LEIME (Cyclin-dependent kinases regulatory subunit OS=Leishmania mexicana OX=5665 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 1.000e-33
Identity = 52/70 (74.29%), Postives = 60/70 (85.71%), Query Frame = 3

Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRT 272
             I YSDKYYDD++EYRHV LP DL +LVP  RLMSE EWR +G+QQS GWVHYMIH+PEPHV+LF+RPRT
Sbjct:   30 KILYSDKYYDDMFEYRHVILPKDLARLVPTSRLMSEMEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT 99

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|P56390|CKS2_MOUSE (Cyclin-dependent kinases regulatory subunit 2 OS=Mus musculus OX=10090 GN=Cks2 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.027e-33
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|P33552|CKS2_HUMAN (Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.140e-33
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A0R3VST8 (Cyclin-dependent kinases regulatory subunit OS=Taenia asiatica OX=60517 GN=TASK_LOCUS252 PE=3 SV=1)

HSP 1 Score: 139.428 bits (350), Expect = 8.873e-40
Identity = 66/88 (75.00%), Postives = 74/88 (84.09%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE---GDQNAVETEN 305
            M+ KNIYYSDKYYDDVYEYRHVHLP +L   VPK RLM+EREWR++GIQQSVGWVHYMIHEPEPHVILFRRPRT+     +NA+   N
Sbjct:    1 MADKNIYYSDKYYDDVYEYRHVHLPKELVGRVPKHRLMTEREWRALGIQQSVGWVHYMIHEPEPHVILFRRPRTDVPPASENALSEPN 88

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: C1LJY4 (Cyclin-dependent kinases regulatory subunit OS=Schistosoma japonicum OX=6182 GN=Cks30A PE=2 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 1.210e-38
Identity = 61/85 (71.76%), Postives = 70/85 (82.35%), Query Frame = 3

Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEAQ 314
            +NIYYS+KYYDDVYEYRHVHLP +L K VPK  LMSE EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+  Q+A    N+ +
Sbjct:    3 RNIYYSEKYYDDVYEYRHVHLPKELAKQVPKNHLMSEMEWRKLGIQQSAGWVHYMIHEPEPHIILFRRPRTDMQQSASAVSNKTE 87

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: Q5BSH4 (Cyclin-dependent kinases regulatory subunit (Fragment) OS=Schistosoma japonicum OX=6182 PE=2 SV=2)

HSP 1 Score: 135.961 bits (341), Expect = 2.402e-38
Identity = 61/84 (72.62%), Postives = 69/84 (82.14%), Query Frame = 3

Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEAQ 314
            NIYYS+KYYDDVYEYRHVHLP +L K VPK  LMSE EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+  Q+A    N+ +
Sbjct:    1 NIYYSEKYYDDVYEYRHVHLPKELAKQVPKNHLMSEMEWRKLGIQQSAGWVHYMIHEPEPHIILFRRPRTDMQQSASAVSNKTE 84

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A504YFK9 (Cyclin-dependent kinases regulatory subunit OS=Fasciola gigantica OX=46835 GN=FGIG_07931 PE=3 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 1.276e-37
Identity = 60/87 (68.97%), Postives = 71/87 (81.61%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEA 311
            MS +NIYYS+KYYD+V EYRHVHLP +L K VP+ RLM+E EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+   N+ +  N A
Sbjct:    1 MSNRNIYYSEKYYDEVNEYRHVHLPKELAKKVPRNRLMTEYEWRELGIQQSAGWVHYMIHEPEPHIILFRRPRTDLPSNSAKPANAA 87

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A4E0RH67 (Cyclin-dependent kinases regulatory subunit OS=Fasciola hepatica OX=6192 GN=D915_003532 PE=3 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 1.470e-37
Identity = 60/87 (68.97%), Postives = 71/87 (81.61%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEA 311
            MS +NIYYS+KYYD+V EYRHVHLP +L K VP+ RLM+E EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+   N+ +  N A
Sbjct:    1 MSNRNIYYSEKYYDEVNEYRHVHLPKELAKKVPRNRLMTEYEWRELGIQQSAGWVHYMIHEPEPHIILFRRPRTDLPSNSAKPTNAA 87

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: zgc:86839 (zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102])

HSP 1 Score: 116.316 bits (290), Expect = 2.982e-34
Identity = 54/73 (73.97%), Postives = 61/73 (83.56%), Query Frame = 3

Query:   48 NMSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             MS K IYYSDKY DD+YEYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP
Sbjct:    2 GMSHKQIYYSDKYNDDLYEYRHVVLPRELAKQVPKSHLMSEDEWRRLGVQQSLGWVHYMIHEPEPHILLFRRP 74

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: cks2 (cyclin-dependent kinases regulatory subunit 1-like [Source:NCBI gene;Acc:103026129])

HSP 1 Score: 115.161 bits (287), Expect = 9.305e-34
Identity = 52/72 (72.22%), Postives = 59/72 (81.94%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP  L+KLVP   LMSE EWR +G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSKKQIYYSDKYTDDEFEYRHVMLPKQLSKLVPTSHLMSEEEWRGLGVQQSQGWVHYMIHKPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: cks1b (cyclin-dependent kinases regulatory subunit 1 [Source:NCBI gene;Acc:103032043])

HSP 1 Score: 113.235 bits (282), Expect = 4.937e-33
Identity = 51/72 (70.83%), Postives = 60/72 (83.33%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ K VPK  LMSE EWR++G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSQKQIYYSDKYDDEKFEYRHVMLPKDIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003167.1 (pep scaffold:Pmarinus_7.0:GL484056:2982:6368:-1 gene:ENSPMAG00000002893.1 transcript:ENSPMAT00000003167.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 79.337 bits (194), Expect = 1.514e-20
Identity = 36/61 (59.02%), Postives = 47/61 (77.05%), Query Frame = 3

Query:   63 NIYYS--DKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPE 239
            +IY S  DKY D+ ++YRHV LP ++ +++PK  LMSE EWRS+G QQS GW+HYM HEPE
Sbjct:    7 DIYQSRKDKYTDEHFQYRHVMLPKEIARMLPKTHLMSEAEWRSLGAQQSHGWMHYMTHEPE 67

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Yeast
Match: CKS1 (Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant [Source:SGD;Acc:S000000339])

HSP 1 Score: 83.9593 bits (206), Expect = 1.176e-21
Identity = 38/77 (49.35%), Postives = 52/77 (67.53%), Query Frame = 3

Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQ---------RLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            +I+YS +Y DD YEYRHV LP  + K++P           R+++E EWR +GI QS+GW HY  H PEPH++LF+RP
Sbjct:   27 SIHYSPRYSDDNYEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGITQSLGWEHYECHAPEPHILLFKRP 103

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO34402 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7SPG3])

HSP 1 Score: 114.39 bits (285), Expect = 7.144e-34
Identity = 51/78 (65.38%), Postives = 62/78 (79.49%), Query Frame = 3

Query:   54 SVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            S+  IYYS+KY+D  YEYRHV +P D+ KLVP+++LM+E EWR IGIQQS GW HYM H PEPH+ILFRR RT+  QN
Sbjct:    3 SIDQIYYSEKYFDSQYEYRHVMVPKDIAKLVPRKKLMTESEWRQIGIQQSQGWQHYMHHHPEPHIILFRRQRTDNPQN 80

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO40682 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7S6M4])

HSP 1 Score: 98.5969 bits (244), Expect = 1.380e-27
Identity = 43/73 (58.90%), Postives = 56/73 (76.71%), Query Frame = 3

Query:   78 DKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP--RTEGDQNA 290
            +KY+D+ +EYRHV LP +L   VP   LM+E EWR++G+QQS GWVHY+IHEPEPHV+LFRRP      +QN+
Sbjct:   14 EKYFDEYFEYRHVMLPKELVSQVPSVHLMTESEWRNLGVQQSPGWVHYLIHEPEPHVLLFRRPLQNNSAEQNS 86

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO45775 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7RSA5])

HSP 1 Score: 93.2041 bits (230), Expect = 1.213e-25
Identity = 45/69 (65.22%), Postives = 51/69 (73.91%), Query Frame = 3

Query:   63 NIYYSDKYYDDV-YEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             I+YS KY DD  YEYRHV +P  L K +PK RLM E EWR +GIQQS GW  YMIH PEPHV+LF+RP
Sbjct:    4 GIFYSTKYEDDTGYEYRHVIVPKVLAKKIPKDRLMREDEWRGMGIQQSQGWQQYMIHHPEPHVLLFKRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Match: cks2 (cyclin-dependent kinases regulatory subunit 1 [Source:NCBI gene;Acc:110014991])

HSP 1 Score: 110.538 bits (275), Expect = 5.038e-32
Identity = 49/72 (68.06%), Postives = 58/72 (80.56%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS   I+YSDKY D+ +EYRHV LP  L+KLVP   LMSE EWR IG+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    1 MSKNQIFYSDKYNDEEFEYRHVVLPKQLSKLVPSSHLMSEEEWRGIGVQQSKGWIHYMIHKPEPHILLFRRP 72

[Close]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Match: cks1b (CDC28 protein kinase regulatory subunit 1B [Source:ZFIN;Acc:ZDB-GENE-040801-112])

HSP 1 Score: 94.7449 bits (234), Expect = 1.909e-25
Identity = 44/68 (64.71%), Postives = 53/68 (77.94%), Query Frame = 3

Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVIL 254
            MS K IYYSDKY DD YEYRHV LP ++ K VPK  LMSE EWR++G+QQS GWVHYMIH+P   +++
Sbjct:    1 MSHKQIYYSDKYDDDKYEYRHVMLPKEIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPGIKLVI 68

The following BLAST results are available for this feature:

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Sea Lamprey
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Yeast
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
BLAST of Cyclin-dependent kinases regulatory subunit vs. Planmine SMEST

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CKS2	4.457e-34	67.09	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]
CKS1B	6.671e-34	73.61	CDC28 protein kinase regulatory subunit 1B [Source...	[more]
CKS1B	1.499e-26	72.58	CDC28 protein kinase regulatory subunit 1B [Source...	[more]
CKS1B	8.784e-24	75.47	CDC28 protein kinase regulatory subunit 1B [Source...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cks-1	8.309e-32	69.57	Cyclin-dependent kinases regulatory subunit [Sour...	[more]
Y71G12B.27	8.148e-28	54.76	Cyclin-dependent kinases regulatory subunit [Sour...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Cks30A	9.749e-35	70.83	gene:FBgn0010314 transcript:FBtr0079799	[more]
Cks85A	3.388e-31	63.64	gene:FBgn0037613 transcript:FBtr0337074	[more]
Cks85A	3.388e-31	63.64	gene:FBgn0037613 transcript:FBtr0081949	[more]
Cks85A	3.388e-31	63.64	gene:FBgn0037613 transcript:FBtr0305339	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cks1b	2.400e-33	72.22	CDC28 protein kinase regulatory subunit 1B [Source...	[more]
zgc:86839	4.648e-33	73.61	zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102]	[more]
cks2	4.614e-32	71.01	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]
cks2	4.614e-32	71.01	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]
cks2	4.614e-32	71.01	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cks2	1.807e-35	69.62	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]
ehd1	2.777e-35	73.61	EH domain containing 1 [Source:Xenbase;Acc:XB-GENE...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cks2	2.898e-34	67.09	CDC28 protein kinase regulatory subunit 2 [Source:...	[more]
Cks1b	4.580e-34	73.61	CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI...	[more]
Cks1brt	4.461e-30	69.44	CDC28 protein kinase 1b, retrogene [Source:MGI Sym...	[more]
Cks1brt	4.461e-30	69.44	CDC28 protein kinase 1b, retrogene [Source:MGI Sym...	[more]
Cks1b	4.398e-22	75.51	CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q91879\|CKS2_XENLA	5.979e-34	68.35	Cyclin-dependent kinases regulatory subunit 2 OS=X...	[more]
sp\|Q24152\|CKS1_DROME	9.772e-34	70.83	Cyclin-dependent kinases regulatory subunit OS=Dro...	[more]
sp\|Q25330\|CKS1_LEIME	1.000e-33	74.29	Cyclin-dependent kinases regulatory subunit OS=Lei...	[more]
sp\|P56390\|CKS2_MOUSE	2.027e-33	67.09	Cyclin-dependent kinases regulatory subunit 2 OS=M...	[more]
sp\|P33552\|CKS2_HUMAN	2.140e-33	67.09	Cyclin-dependent kinases regulatory subunit 2 OS=H...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0R3VST8	8.873e-40	75.00	Cyclin-dependent kinases regulatory subunit OS=Tae...	[more]
C1LJY4	1.210e-38	71.76	Cyclin-dependent kinases regulatory subunit OS=Sch...	[more]
Q5BSH4	2.402e-38	72.62	Cyclin-dependent kinases regulatory subunit (Fragm...	[more]
A0A504YFK9	1.276e-37	68.97	Cyclin-dependent kinases regulatory subunit OS=Fas...	[more]
A0A4E0RH67	1.470e-37	68.97	Cyclin-dependent kinases regulatory subunit OS=Fas...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
zgc:86839	2.982e-34	73.97	zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102]	[more]
cks2	9.305e-34	72.22	cyclin-dependent kinases regulatory subunit 1-like...	[more]
cks1b	4.937e-33	70.83	cyclin-dependent kinases regulatory subunit 1 [Sou...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000003167.1	1.514e-20	59.02	pep scaffold:Pmarinus_7.0:GL484056:2982:6368:-1 ge...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
CKS1	1.176e-21	49.35	Cyclin-dependent protein kinase regulatory subunit...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO34402	7.144e-34	65.38	Cyclin-dependent kinases regulatory subunit [Sour...	[more]
EDO40682	1.380e-27	58.90	Cyclin-dependent kinases regulatory subunit [Sour...	[more]
EDO45775	1.213e-25	65.22	Cyclin-dependent kinases regulatory subunit [Sour...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cks2	5.038e-32	68.06	cyclin-dependent kinases regulatory subunit 1 [Sou...	[more]
cks1b	1.909e-25	64.71	CDC28 protein kinase regulatory subunit 1B [Source...	[more]

BLAST of Cyclin-dependent kinases regulatory subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 0


Match Name	E-value	Identity	Description

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30015678 ID=SMED30015678|Name=Cyclin-dependent kinases regulatory subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=519bp
TGTTTAAACACATAATTTTTCAATTTTAAAAATTATAATATTACTGAAAC
ATGTCTGTCAAGAATATTTATTATTCTGATAAATATTACGATGATGTCTA
TGAATATAGACATGTACATTTGCCTGCTGATTTAACGAAGTTAGTACCTA
AACAACGACTTATGTCTGAAAGAGAATGGCGTAGCATTGGAATCCAACAA
TCAGTTGGATGGGTTCATTATATGATTCATGAACCTGAGCCACATGTAAT
ATTATTTAGACGCCCAAGAACTGAAGGTGACCAAAACGCTGTTGAAACTG
AAAATGAAGCTCAAAAAGTTTAAATTGTTCCTTCGATAAAAAATATAGAC
AGAGTTATTAATGTACATTAGGCATTTTTTATAATAATGTAAAAAATCGT
CGAAATTCTAATTGTTATAATTACCATTAATTGAAAGTGAATGCTTTTCA
AATTGATTCGAATAAATGTTTTTAGCAAAATAAAATTATTACATTGAAAA
AAAAAAAAAAAAAATGCGA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007049	cell cycle
GO:0045859	regulation of protein kinase activity
GO:0051301	cell division

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000418	head
PLANA:0000420	parapharyngeal region
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR036858	Cyclin-dep_kinase_reg-sub_sf
IPR000789	Cyclin-dep_kinase_reg-sub

Vocabulary: **molecular function**
Term	Definition
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000789	Cyclin-dependent kinase, regulatory subunit	PRINTS	PR00296	CYCLINKINASE	coord: 20..34 score: 61.54 coord: 42..56 score: 73.33 coord: 5..19 score: 66.67 coord: 57..71 score: 75.9
IPR000789	Cyclin-dependent kinase, regulatory subunit	SMART	SM01084	CKS_2	coord: 5..74 e-value: 5.3E-44 score: 162.2
IPR000789	Cyclin-dependent kinase, regulatory subunit	PFAM	PF01111	CKS	coord: 6..72 e-value: 8.8E-36 score: 122.0
IPR036858	Cyclin-dependent kinase, regulatory subunit superfamily	GENE3D	G3DSA:3.30.170.10		coord: 1..79 e-value: 1.8E-38 score: 132.3
IPR036858	Cyclin-dependent kinase, regulatory subunit superfamily	SUPERFAMILY	SSF55637	Cell cycle regulatory proteins	coord: 2..78
None	No IPR available	PANTHER	PTHR23415:SF29	CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT-RELATED	coord: 4..79
None	No IPR available	PANTHER	PTHR23415	CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7	coord: 4..79

Main menu

Cyclin-dependent kinases regulatory subunit

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Owlery

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