Cyclin-dependent kinases regulatory subunit

Overview
NameCyclin-dependent kinases regulatory subunit
Smed IDSMED30015678
Length (bp)519
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cyclin-dependent kinases regulatory subunit (SMED30015678) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinases regulatory subunit (SMED30015678) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinases regulatory subunit (SMED30015678) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cyclin-dependent kinases regulatory subunit (SMED30015678) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30015678

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30015678 SmedASXL_028678SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30015678 SmedASXL_028678SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30015678 dd_Smed_v4_6668_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30015678 dd_Smed_v6_6668_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
parenchymaSMED30015678 Contig44265newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30015678 Contig44265uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30015678 OX_Smed_1.0.17435ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
zeta neoblastSMED30015678 dd_Smed_v4_6668_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30015678 SMED_24896_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30015678 SMED_24896_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30015678 SMED_09394_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30015678 SMED_09394_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS2 (CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000])

HSP 1 Score: 116.701 bits (291), Expect = 4.457e-34
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 115.931 bits (289), Expect = 6.671e-34
Identity = 53/72 (73.61%), Postives = 61/72 (84.72%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 97.0561 bits (240), Expect = 1.499e-26
Identity = 45/62 (72.58%), Postives = 51/62 (82.26%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEP 236
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEP 62          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Match: CKS1B (CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083])

HSP 1 Score: 89.7373 bits (221), Expect = 8.784e-24
Identity = 40/53 (75.47%), Postives = 46/53 (86.79%), Query Frame = 3
Query:  108 RHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            RHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    4 RHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 56          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Match: cks-1 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:Q17868])

HSP 1 Score: 110.153 bits (274), Expect = 8.309e-32
Identity = 48/69 (69.57%), Postives = 58/69 (84.06%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             + YYS+KY DD +EYRHVH+  D++KL+PK RLMSE EWRS+GIQQS GW+HYMIH PE HV+LFRRP
Sbjct:    6 NDFYYSNKYEDDEFEYRHVHVTKDVSKLIPKNRLMSETEWRSLGIQQSPGWMHYMIHGPERHVLLFRRP 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Match: Y71G12B.27 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:Q95XM4])

HSP 1 Score: 100.908 bits (250), Expect = 8.148e-28
Identity = 46/84 (54.76%), Postives = 62/84 (73.81%), Query Frame = 3
Query:   57 VKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPR--TEGDQNAVETE 302
            +++IYYS +Y DD YEYRHV LP  +++ VPK RL+SE EWR  G+QQS+GW HYM+H PE H++LFRR R  T+ D+   + E
Sbjct:    1 MEDIYYSPRYEDDEYEYRHVILPQAVSRKVPKGRLLSEAEWRRAGVQQSLGWEHYMVHNPEKHILLFRRKRHFTKADEERAKME 84          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks30A (gene:FBgn0010314 transcript:FBtr0079799)

HSP 1 Score: 117.087 bits (292), Expect = 9.749e-35
Identity = 51/72 (70.83%), Postives = 64/72 (88.89%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE 275
            K+IYYSDKYYD+ +EYRHV LP +L K+VPK  LM+E EWRSIG+QQS GW+HYMIH+PEPH++LFRRP+T+
Sbjct:    3 KDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0337074)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0081949)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Match: Cks85A (gene:FBgn0037613 transcript:FBtr0305339)

HSP 1 Score: 108.997 bits (271), Expect = 3.388e-31
Identity = 49/77 (63.64%), Postives = 58/77 (75.32%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGD 281
            M    I YS+KY+DD +EYRHV LP DL K VPK  LM+E EWR++G+QQS GWVHYM+H PEPHVILFRR R   +
Sbjct:    1 MPADQIQYSEKYFDDNFEYRHVILPPDLAKHVPKAHLMTETEWRNLGVQQSPGWVHYMVHAPEPHVILFRRKRIPAE 77          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks1b (CDC28 protein kinase regulatory subunit 1B [Source:ZFIN;Acc:ZDB-GENE-040801-112])

HSP 1 Score: 114.39 bits (285), Expect = 2.400e-33
Identity = 52/72 (72.22%), Postives = 60/72 (83.33%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP D+ K VPK  LMSE EWR++G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDDKFEYRHVMLPKDIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: zgc:86839 (zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102])

HSP 1 Score: 113.235 bits (282), Expect = 4.648e-33
Identity = 53/72 (73.61%), Postives = 60/72 (83.33%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYTDDHFEYRHVVLPRELAKQVPKSHLMSEDEWRRLGVQQSLGWVHYMIHEPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:ZFIN;Acc:ZDB-GENE-050208-508])

HSP 1 Score: 110.923 bits (276), Expect = 4.614e-32
Identity = 49/69 (71.01%), Postives = 57/69 (82.61%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:ZFIN;Acc:ZDB-GENE-050208-508])

HSP 1 Score: 110.923 bits (276), Expect = 4.614e-32
Identity = 49/69 (71.01%), Postives = 57/69 (82.61%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:ZFIN;Acc:ZDB-GENE-050208-508])

HSP 1 Score: 110.923 bits (276), Expect = 4.614e-32
Identity = 49/69 (71.01%), Postives = 57/69 (82.61%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            K IYYSDKY D+ YEYRHV LP  L+KLVP   LMSE EWR +G+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    6 KQIYYSDKYSDEEYEYRHVMLPKQLSKLVPSSHLMSEEEWRGLGVQQSQGWIHYMIHKPEPHILLFRRP 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:NCBI gene;Acc:548924])

HSP 1 Score: 120.168 bits (300), Expect = 1.807e-35
Identity = 55/79 (69.62%), Postives = 63/79 (79.75%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            MS KNIYYSDKY D+ YEYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MSFKNIYYSDKYSDENYEYRHVMLPKELAKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Match: ehd1 (EH domain containing 1 [Source:Xenbase;Acc:XB-GENE-490186])

HSP 1 Score: 119.398 bits (298), Expect = 2.777e-35
Identity = 53/72 (73.61%), Postives = 62/72 (86.11%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS KNIYYSDKY D++YEYRHV LP D  K+VPK  L+SE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSAKNIYYSDKYDDELYEYRHVMLPKDFAKMVPKTHLISESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks2 (CDC28 protein kinase regulatory subunit 2 [Source:MGI Symbol;Acc:MGI:1913447])

HSP 1 Score: 116.701 bits (291), Expect = 2.898e-34
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1b (CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208])

HSP 1 Score: 115.931 bits (289), Expect = 4.580e-34
Identity = 53/72 (73.61%), Postives = 61/72 (84.72%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    1 MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1brt (CDC28 protein kinase 1b, retrogene [Source:MGI Symbol;Acc:MGI:3643620])

HSP 1 Score: 106.686 bits (265), Expect = 4.461e-30
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR +G+QQS GWVHYMIHEPE H++LF+ P
Sbjct:   18 MSHKQIYYSDKYDDEEFEYRHVMLPKDIDKLVPKTHLMSESEWRKLGVQQSQGWVHYMIHEPELHILLFQWP 89          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1brt (CDC28 protein kinase 1b, retrogene [Source:MGI Symbol;Acc:MGI:3643620])

HSP 1 Score: 106.686 bits (265), Expect = 4.461e-30
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ KLVPK  LMSE EWR +G+QQS GWVHYMIHEPE H++LF+ P
Sbjct:   18 MSHKQIYYSDKYDDEEFEYRHVMLPKDIDKLVPKTHLMSESEWRKLGVQQSQGWVHYMIHEPELHILLFQWP 89          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Match: Cks1b (CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208])

HSP 1 Score: 84.7297 bits (208), Expect = 4.398e-22
Identity = 37/49 (75.51%), Postives = 43/49 (87.76%), Query Frame = 3
Query:  120 LPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            LP D+ KLVPK  LMSE EWR++G+QQS GWVHYMIHEPEPH++LFRRP
Sbjct:    2 LPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRP 50          
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q91879|CKS2_XENLA (Cyclin-dependent kinases regulatory subunit 2 OS=Xenopus laevis OX=8355 GN=cks2 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 5.979e-34
Identity = 54/79 (68.35%), Postives = 63/79 (79.75%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            MS KNIYYSDKY D+ +EYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MSYKNIYYSDKYTDEHFEYRHVMLPKELAKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q24152|CKS1_DROME (Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks30A PE=3 SV=1)

HSP 1 Score: 117.087 bits (292), Expect = 9.772e-34
Identity = 51/72 (70.83%), Postives = 64/72 (88.89%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE 275
            K+IYYSDKYYD+ +EYRHV LP +L K+VPK  LM+E EWRSIG+QQS GW+HYMIH+PEPH++LFRRP+T+
Sbjct:    3 KDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|Q25330|CKS1_LEIME (Cyclin-dependent kinases regulatory subunit OS=Leishmania mexicana OX=5665 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 1.000e-33
Identity = 52/70 (74.29%), Postives = 60/70 (85.71%), Query Frame = 3
Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRT 272
             I YSDKYYDD++EYRHV LP DL +LVP  RLMSE EWR +G+QQS GWVHYMIH+PEPHV+LF+RPRT
Sbjct:   30 KILYSDKYYDDMFEYRHVILPKDLARLVPTSRLMSEMEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT 99          
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|P56390|CKS2_MOUSE (Cyclin-dependent kinases regulatory subunit 2 OS=Mus musculus OX=10090 GN=Cks2 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.027e-33
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Match: sp|P33552|CKS2_HUMAN (Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.140e-33
Identity = 53/79 (67.09%), Postives = 64/79 (81.01%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            M+ K IYYSDKY+D+ YEYRHV LP +L+K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP  +  Q 
Sbjct:    1 MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK 79          
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A0R3VST8 (Cyclin-dependent kinases regulatory subunit OS=Taenia asiatica OX=60517 GN=TASK_LOCUS252 PE=3 SV=1)

HSP 1 Score: 139.428 bits (350), Expect = 8.873e-40
Identity = 66/88 (75.00%), Postives = 74/88 (84.09%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTE---GDQNAVETEN 305
            M+ KNIYYSDKYYDDVYEYRHVHLP +L   VPK RLM+EREWR++GIQQSVGWVHYMIHEPEPHVILFRRPRT+     +NA+   N
Sbjct:    1 MADKNIYYSDKYYDDVYEYRHVHLPKELVGRVPKHRLMTEREWRALGIQQSVGWVHYMIHEPEPHVILFRRPRTDVPPASENALSEPN 88          
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: C1LJY4 (Cyclin-dependent kinases regulatory subunit OS=Schistosoma japonicum OX=6182 GN=Cks30A PE=2 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 1.210e-38
Identity = 61/85 (71.76%), Postives = 70/85 (82.35%), Query Frame = 3
Query:   60 KNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEAQ 314
            +NIYYS+KYYDDVYEYRHVHLP +L K VPK  LMSE EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+  Q+A    N+ +
Sbjct:    3 RNIYYSEKYYDDVYEYRHVHLPKELAKQVPKNHLMSEMEWRKLGIQQSAGWVHYMIHEPEPHIILFRRPRTDMQQSASAVSNKTE 87          
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: Q5BSH4 (Cyclin-dependent kinases regulatory subunit (Fragment) OS=Schistosoma japonicum OX=6182 PE=2 SV=2)

HSP 1 Score: 135.961 bits (341), Expect = 2.402e-38
Identity = 61/84 (72.62%), Postives = 69/84 (82.14%), Query Frame = 3
Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEAQ 314
            NIYYS+KYYDDVYEYRHVHLP +L K VPK  LMSE EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+  Q+A    N+ +
Sbjct:    1 NIYYSEKYYDDVYEYRHVHLPKELAKQVPKNHLMSEMEWRKLGIQQSAGWVHYMIHEPEPHIILFRRPRTDMQQSASAVSNKTE 84          
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A504YFK9 (Cyclin-dependent kinases regulatory subunit OS=Fasciola gigantica OX=46835 GN=FGIG_07931 PE=3 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 1.276e-37
Identity = 60/87 (68.97%), Postives = 71/87 (81.61%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEA 311
            MS +NIYYS+KYYD+V EYRHVHLP +L K VP+ RLM+E EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+   N+ +  N A
Sbjct:    1 MSNRNIYYSEKYYDEVNEYRHVHLPKELAKKVPRNRLMTEYEWRELGIQQSAGWVHYMIHEPEPHIILFRRPRTDLPSNSAKPANAA 87          
BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Match: A0A4E0RH67 (Cyclin-dependent kinases regulatory subunit OS=Fasciola hepatica OX=6192 GN=D915_003532 PE=3 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 1.470e-37
Identity = 60/87 (68.97%), Postives = 71/87 (81.61%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQNAVETENEA 311
            MS +NIYYS+KYYD+V EYRHVHLP +L K VP+ RLM+E EWR +GIQQS GWVHYMIHEPEPH+ILFRRPRT+   N+ +  N A
Sbjct:    1 MSNRNIYYSEKYYDEVNEYRHVHLPKELAKKVPRNRLMTEYEWRELGIQQSAGWVHYMIHEPEPHIILFRRPRTDLPSNSAKPTNAA 87          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: zgc:86839 (zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102])

HSP 1 Score: 116.316 bits (290), Expect = 2.982e-34
Identity = 54/73 (73.97%), Postives = 61/73 (83.56%), Query Frame = 3
Query:   48 NMSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             MS K IYYSDKY DD+YEYRHV LP +L K VPK  LMSE EWR +G+QQS+GWVHYMIHEPEPH++LFRRP
Sbjct:    2 GMSHKQIYYSDKYNDDLYEYRHVVLPRELAKQVPKSHLMSEDEWRRLGVQQSLGWVHYMIHEPEPHILLFRRP 74          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: cks2 (cyclin-dependent kinases regulatory subunit 1-like [Source:NCBI gene;Acc:103026129])

HSP 1 Score: 115.161 bits (287), Expect = 9.305e-34
Identity = 52/72 (72.22%), Postives = 59/72 (81.94%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY DD +EYRHV LP  L+KLVP   LMSE EWR +G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSKKQIYYSDKYTDDEFEYRHVMLPKQLSKLVPTSHLMSEEEWRGLGVQQSQGWVHYMIHKPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Match: cks1b (cyclin-dependent kinases regulatory subunit 1 [Source:NCBI gene;Acc:103032043])

HSP 1 Score: 113.235 bits (282), Expect = 4.937e-33
Identity = 51/72 (70.83%), Postives = 60/72 (83.33%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS K IYYSDKY D+ +EYRHV LP D+ K VPK  LMSE EWR++G+QQS GWVHYMIH+PEPH++LFRRP
Sbjct:    1 MSQKQIYYSDKYDDEKFEYRHVMLPKDIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003167.1 (pep scaffold:Pmarinus_7.0:GL484056:2982:6368:-1 gene:ENSPMAG00000002893.1 transcript:ENSPMAT00000003167.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 79.337 bits (194), Expect = 1.514e-20
Identity = 36/61 (59.02%), Postives = 47/61 (77.05%), Query Frame = 3
Query:   63 NIYYS--DKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPE 239
            +IY S  DKY D+ ++YRHV LP ++ +++PK  LMSE EWRS+G QQS GW+HYM HEPE
Sbjct:    7 DIYQSRKDKYTDEHFQYRHVMLPKEIARMLPKTHLMSEAEWRSLGAQQSHGWMHYMTHEPE 67          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Yeast
Match: CKS1 (Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant [Source:SGD;Acc:S000000339])

HSP 1 Score: 83.9593 bits (206), Expect = 1.176e-21
Identity = 38/77 (49.35%), Postives = 52/77 (67.53%), Query Frame = 3
Query:   63 NIYYSDKYYDDVYEYRHVHLPADLTKLVPKQ---------RLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            +I+YS +Y DD YEYRHV LP  + K++P           R+++E EWR +GI QS+GW HY  H PEPH++LF+RP
Sbjct:   27 SIHYSPRYSDDNYEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGITQSLGWEHYECHAPEPHILLFKRP 103          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO34402 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7SPG3])

HSP 1 Score: 114.39 bits (285), Expect = 7.144e-34
Identity = 51/78 (65.38%), Postives = 62/78 (79.49%), Query Frame = 3
Query:   54 SVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRPRTEGDQN 287
            S+  IYYS+KY+D  YEYRHV +P D+ KLVP+++LM+E EWR IGIQQS GW HYM H PEPH+ILFRR RT+  QN
Sbjct:    3 SIDQIYYSEKYFDSQYEYRHVMVPKDIAKLVPRKKLMTESEWRQIGIQQSQGWQHYMHHHPEPHIILFRRQRTDNPQN 80          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO40682 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7S6M4])

HSP 1 Score: 98.5969 bits (244), Expect = 1.380e-27
Identity = 43/73 (58.90%), Postives = 56/73 (76.71%), Query Frame = 3
Query:   78 DKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP--RTEGDQNA 290
            +KY+D+ +EYRHV LP +L   VP   LM+E EWR++G+QQS GWVHY+IHEPEPHV+LFRRP      +QN+
Sbjct:   14 EKYFDEYFEYRHVMLPKELVSQVPSVHLMTESEWRNLGVQQSPGWVHYLIHEPEPHVLLFRRPLQNNSAEQNS 86          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Match: EDO45775 (Cyclin-dependent kinases regulatory subunit [Source:UniProtKB/TrEMBL;Acc:A7RSA5])

HSP 1 Score: 93.2041 bits (230), Expect = 1.213e-25
Identity = 45/69 (65.22%), Postives = 51/69 (73.91%), Query Frame = 3
Query:   63 NIYYSDKYYDDV-YEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
             I+YS KY DD  YEYRHV +P  L K +PK RLM E EWR +GIQQS GW  YMIH PEPHV+LF+RP
Sbjct:    4 GIFYSTKYEDDTGYEYRHVIVPKVLAKKIPKDRLMREDEWRGMGIQQSQGWQQYMIHHPEPHVLLFKRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Match: cks2 (cyclin-dependent kinases regulatory subunit 1 [Source:NCBI gene;Acc:110014991])

HSP 1 Score: 110.538 bits (275), Expect = 5.038e-32
Identity = 49/72 (68.06%), Postives = 58/72 (80.56%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVILFRRP 266
            MS   I+YSDKY D+ +EYRHV LP  L+KLVP   LMSE EWR IG+QQS GW+HYMIH+PEPH++LFRRP
Sbjct:    1 MSKNQIFYSDKYNDEEFEYRHVVLPKQLSKLVPSSHLMSEEEWRGIGVQQSKGWIHYMIHKPEPHILLFRRP 72          
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Match: cks1b (CDC28 protein kinase regulatory subunit 1B [Source:ZFIN;Acc:ZDB-GENE-040801-112])

HSP 1 Score: 94.7449 bits (234), Expect = 1.909e-25
Identity = 44/68 (64.71%), Postives = 53/68 (77.94%), Query Frame = 3
Query:   51 MSVKNIYYSDKYYDDVYEYRHVHLPADLTKLVPKQRLMSEREWRSIGIQQSVGWVHYMIHEPEPHVIL 254
            MS K IYYSDKY DD YEYRHV LP ++ K VPK  LMSE EWR++G+QQS GWVHYMIH+P   +++
Sbjct:    1 MSHKQIYYSDKYDDDKYEYRHVMLPKEIAKRVPKTHLMSETEWRNLGVQQSQGWVHYMIHQPGIKLVI 68          
The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
CKS24.457e-3467.09CDC28 protein kinase regulatory subunit 2 [Source:... [more]
CKS1B6.671e-3473.61CDC28 protein kinase regulatory subunit 1B [Source... [more]
CKS1B1.499e-2672.58CDC28 protein kinase regulatory subunit 1B [Source... [more]
CKS1B8.784e-2475.47CDC28 protein kinase regulatory subunit 1B [Source... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cks-18.309e-3269.57Cyclin-dependent kinases regulatory subunit [Sour... [more]
Y71G12B.278.148e-2854.76Cyclin-dependent kinases regulatory subunit [Sour... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Cks30A9.749e-3570.83gene:FBgn0010314 transcript:FBtr0079799[more]
Cks85A3.388e-3163.64gene:FBgn0037613 transcript:FBtr0337074[more]
Cks85A3.388e-3163.64gene:FBgn0037613 transcript:FBtr0081949[more]
Cks85A3.388e-3163.64gene:FBgn0037613 transcript:FBtr0305339[more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cks1b2.400e-3372.22CDC28 protein kinase regulatory subunit 1B [Source... [more]
zgc:868394.648e-3373.61zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102][more]
cks24.614e-3271.01CDC28 protein kinase regulatory subunit 2 [Source:... [more]
cks24.614e-3271.01CDC28 protein kinase regulatory subunit 2 [Source:... [more]
cks24.614e-3271.01CDC28 protein kinase regulatory subunit 2 [Source:... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cks21.807e-3569.62CDC28 protein kinase regulatory subunit 2 [Source:... [more]
ehd12.777e-3573.61EH domain containing 1 [Source:Xenbase;Acc:XB-GENE... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cks22.898e-3467.09CDC28 protein kinase regulatory subunit 2 [Source:... [more]
Cks1b4.580e-3473.61CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI... [more]
Cks1brt4.461e-3069.44CDC28 protein kinase 1b, retrogene [Source:MGI Sym... [more]
Cks1brt4.461e-3069.44CDC28 protein kinase 1b, retrogene [Source:MGI Sym... [more]
Cks1b4.398e-2275.51CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q91879|CKS2_XENLA5.979e-3468.35Cyclin-dependent kinases regulatory subunit 2 OS=X... [more]
sp|Q24152|CKS1_DROME9.772e-3470.83Cyclin-dependent kinases regulatory subunit OS=Dro... [more]
sp|Q25330|CKS1_LEIME1.000e-3374.29Cyclin-dependent kinases regulatory subunit OS=Lei... [more]
sp|P56390|CKS2_MOUSE2.027e-3367.09Cyclin-dependent kinases regulatory subunit 2 OS=M... [more]
sp|P33552|CKS2_HUMAN2.140e-3367.09Cyclin-dependent kinases regulatory subunit 2 OS=H... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0R3VST88.873e-4075.00Cyclin-dependent kinases regulatory subunit OS=Tae... [more]
C1LJY41.210e-3871.76Cyclin-dependent kinases regulatory subunit OS=Sch... [more]
Q5BSH42.402e-3872.62Cyclin-dependent kinases regulatory subunit (Fragm... [more]
A0A504YFK91.276e-3768.97Cyclin-dependent kinases regulatory subunit OS=Fas... [more]
A0A4E0RH671.470e-3768.97Cyclin-dependent kinases regulatory subunit OS=Fas... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
zgc:868392.982e-3473.97zgc:86839 [Source:ZFIN;Acc:ZDB-GENE-040625-102][more]
cks29.305e-3472.22cyclin-dependent kinases regulatory subunit 1-like... [more]
cks1b4.937e-3370.83cyclin-dependent kinases regulatory subunit 1 [Sou... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000003167.11.514e-2059.02pep scaffold:Pmarinus_7.0:GL484056:2982:6368:-1 ge... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
CKS11.176e-2149.35Cyclin-dependent protein kinase regulatory subunit... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO344027.144e-3465.38Cyclin-dependent kinases regulatory subunit [Sour... [more]
EDO406821.380e-2758.90Cyclin-dependent kinases regulatory subunit [Sour... [more]
EDO457751.213e-2565.22Cyclin-dependent kinases regulatory subunit [Sour... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cks25.038e-3268.06cyclin-dependent kinases regulatory subunit 1 [Sou... [more]
cks1b1.909e-2564.71CDC28 protein kinase regulatory subunit 1B [Source... [more]
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BLAST of Cyclin-dependent kinases regulatory subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 0
Match NameE-valueIdentityDescription
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015678 ID=SMED30015678|Name=Cyclin-dependent kinases regulatory subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=519bp
TGTTTAAACACATAATTTTTCAATTTTAAAAATTATAATATTACTGAAAC
ATGTCTGTCAAGAATATTTATTATTCTGATAAATATTACGATGATGTCTA
TGAATATAGACATGTACATTTGCCTGCTGATTTAACGAAGTTAGTACCTA
AACAACGACTTATGTCTGAAAGAGAATGGCGTAGCATTGGAATCCAACAA
TCAGTTGGATGGGTTCATTATATGATTCATGAACCTGAGCCACATGTAAT
ATTATTTAGACGCCCAAGAACTGAAGGTGACCAAAACGCTGTTGAAACTG
AAAATGAAGCTCAAAAAGTTTAAATTGTTCCTTCGATAAAAAATATAGAC
AGAGTTATTAATGTACATTAGGCATTTTTTATAATAATGTAAAAAATCGT
CGAAATTCTAATTGTTATAATTACCATTAATTGAAAGTGAATGCTTTTCA
AATTGATTCGAATAAATGTTTTTAGCAAAATAAAATTATTACATTGAAAA
AAAAAAAAAAAAAATGCGA
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007049cell cycle
GO:0045859regulation of protein kinase activity
GO:0051301cell division
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000418head
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR036858Cyclin-dep_kinase_reg-sub_sf
IPR000789Cyclin-dep_kinase_reg-sub
Vocabulary: molecular function
TermDefinition
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000789Cyclin-dependent kinase, regulatory subunitPRINTSPR00296CYCLINKINASEcoord: 20..34
score: 61.54
coord: 42..56
score: 73.33
coord: 5..19
score: 66.67
coord: 57..71
score: 75.9
IPR000789Cyclin-dependent kinase, regulatory subunitSMARTSM01084CKS_2coord: 5..74
e-value: 5.3E-44
score: 162.2
IPR000789Cyclin-dependent kinase, regulatory subunitPFAMPF01111CKScoord: 6..72
e-value: 8.8E-36
score: 122.0
IPR036858Cyclin-dependent kinase, regulatory subunit superfamilyGENE3DG3DSA:3.30.170.10coord: 1..79
e-value: 1.8E-38
score: 132.3
IPR036858Cyclin-dependent kinase, regulatory subunit superfamilySUPERFAMILYSSF55637Cell cycle regulatory proteinscoord: 2..78
NoneNo IPR availablePANTHERPTHR23415:SF29CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT-RELATEDcoord: 4..79
NoneNo IPR availablePANTHERPTHR23415CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7coord: 4..79