GLI-2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30015613 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of GLI-2 vs. Ensembl Human
Match: GLI2 (GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318]) HSP 1 Score: 243.047 bits (619), Expect = 1.340e-70 Identity = 111/174 (63.79%), Postives = 129/174 (74.14%), Query Frame = 3
Query: 117 GKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
++ I CHWE CTK+ E LV+HI +HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K ++ +
Sbjct: 430 AEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEF-VCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRND 602
BLAST of GLI-2 vs. Ensembl Human
Match: GLI2 (GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318]) HSP 1 Score: 243.047 bits (619), Expect = 1.340e-70 Identity = 111/174 (63.79%), Postives = 129/174 (74.14%), Query Frame = 3
Query: 117 GKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
++ I CHWE CTK+ E LV+HI +HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K ++ +
Sbjct: 430 AEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEF-VCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRND 602
BLAST of GLI-2 vs. Ensembl Human
Match: GLI3 (GLI family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:4319]) HSP 1 Score: 238.039 bits (606), Expect = 7.522e-69 Identity = 110/170 (64.71%), Postives = 128/170 (75.29%), Query Frame = 3
Query: 129 INTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
I CHWE C ++ E LV+HI HI KK + +C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 418 IYETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEF-VCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 586
BLAST of GLI-2 vs. Ensembl Human
Match: GLI3 (GLI family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:4319]) HSP 1 Score: 237.269 bits (604), Expect = 1.420e-68 Identity = 110/170 (64.71%), Postives = 128/170 (75.29%), Query Frame = 3
Query: 129 INTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
I CHWE C ++ E LV+HI HI KK + +C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 477 IYETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEF-VCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 645
BLAST of GLI-2 vs. Ensembl Human
Match: GLI1 (GLI family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:4317]) HSP 1 Score: 233.032 bits (593), Expect = 9.272e-68 Identity = 108/186 (58.06%), Postives = 130/186 (69.89%), Query Frame = 3
Query: 126 SINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKK 683
S+ C W+ C+++ E LV+HI ++HI +K ++C W C R +PFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE C+K FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K +G+ R I + K
Sbjct: 103 SVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERK-EFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPK 287
BLAST of GLI-2 vs. Ensembl Celegans
Match: tra-1 (Sex-determining transformer protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P34708]) HSP 1 Score: 207.223 bits (526), Expect = 8.479e-59 Identity = 101/177 (57.06%), Postives = 121/177 (68.36%), Query Frame = 3
Query: 108 NDHGKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYI--CQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKK 632
ND + + C W+SC + LV+H+ H+ ++ ++ C+W C RN+ FKA YML+VH+RRHTGEKP+KCEY C K YSRLENLKTH RTHTGEKPY CEF C K FSNASDRAKHQNRTHSN KPY C++ C K YTDPSSLRKH+K H + Y EK KK
Sbjct: 198 NDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNET-FKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEY-EKAKK 372
BLAST of GLI-2 vs. Ensembl Celegans
Match: ztf-14 (Zinc finger putative Transcription Factor family [Source:UniProtKB/TrEMBL;Acc:Q93902]) HSP 1 Score: 141.739 bits (356), Expect = 2.624e-37 Identity = 90/217 (41.47%), Postives = 114/217 (52.53%), Query Frame = 3
Query: 132 NTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDP 782
+ +C W+ CT D T H+ HI +K C+W C R+ FK Y H R HT +K + CE C K Y RLENLKTH RTHTGEKPY+C +CNK F+NASDR+KH RTHSN+KPY C C YTDPSSLRKHVK+ H +A K+ ++ I I +K + + A+ LP L L + P
Sbjct: 229 DVRQCLWDGCTLTLDDRATFFVHV-DNHI---QKNEVNCKWRYCERS---FKQTYEFTAHKRTHTKQKLYCCEV--CPKRYGRLENLKTHRRTHTGEKPYHCNVPNCNKSFTNASDRSKHSKRTHSNEKPYCCDFGSCACAYTDPSSLRKHVKSKHPEH-HAMKMAMRKTQRKSIKQIASEKVQ-----MSPLPTAAEAPISPQQNLPTLPLNMIPP 430
BLAST of GLI-2 vs. Ensembl Celegans
Match: ref-2 (REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:Q7JNM3]) HSP 1 Score: 135.961 bits (341), Expect = 1.388e-36 Identity = 78/178 (43.82%), Postives = 103/178 (57.87%), Query Frame = 3
Query: 141 KCHWES----CTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINV 662
+C WE+ C C + L HI + HI+ K ++C W C R K FKA+Y LV HMR HTGE+P C+ C+K ++R ENLK H R H+GEKP+ C C K F+N+SDR KH + HS+ KPY C C K YT PSSLRKH K H+N+ ++ + + SD N
Sbjct: 71 QCLWETNGQVCMHVCQNSGELSTHISSNHITHDSK--FVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMH-VHSSHKPYSCMYPDCGKTYTHPSSLRKHTKV-HENEKKSQLSPEHDESSDSGNA 242
BLAST of GLI-2 vs. Ensembl Celegans
Match: ref-2 (REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:Q7JNM3]) HSP 1 Score: 135.961 bits (341), Expect = 1.388e-36 Identity = 78/178 (43.82%), Postives = 103/178 (57.87%), Query Frame = 3
Query: 141 KCHWES----CTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINV 662
+C WE+ C C + L HI + HI+ K ++C W C R K FKA+Y LV HMR HTGE+P C+ C+K ++R ENLK H R H+GEKP+ C C K F+N+SDR KH + HS+ KPY C C K YT PSSLRKH K H+N+ ++ + + SD N
Sbjct: 71 QCLWETNGQVCMHVCQNSGELSTHISSNHITHDSK--FVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMH-VHSSHKPYSCMYPDCGKTYTHPSSLRKHTKV-HENEKKSQLSPEHDESSDSGNA 242
BLAST of GLI-2 vs. Ensembl Celegans
Match: ref-2 (REgulator of Fusion [Source:UniProtKB/TrEMBL;Acc:Q7JNM3]) HSP 1 Score: 135.961 bits (341), Expect = 1.409e-36 Identity = 78/178 (43.82%), Postives = 103/178 (57.87%), Query Frame = 3
Query: 141 KCHWES----CTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINV 662
+C WE+ C C + L HI + HI+ K ++C W C R K FKA+Y LV HMR HTGE+P C+ C+K ++R ENLK H R H+GEKP+ C C K F+N+SDR KH + HS+ KPY C C K YT PSSLRKH K H+N+ ++ + + SD N
Sbjct: 84 QCLWETNGQVCMHVCQNSGELSTHISSNHITHDSK--FVCLWKGCDREFKMFKAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKHMH-VHSSHKPYSCMYPDCGKTYTHPSSLRKHTKV-HENEKKSQLSPEHDESSDSGNA 255
BLAST of GLI-2 vs. Ensembl Fly
Match: ci (gene:FBgn0004859 transcript:FBtr0306168) HSP 1 Score: 245.743 bits (626), Expect = 7.272e-72 Identity = 127/239 (53.14%), Postives = 155/239 (64.85%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKN---------YTVNEIRNSDSKI 833
CHW SC + + LV HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE+ C+K FSNASDRAKHQNRTHSN+KPY CK GC KRYTDPSSLRKHVKT H + YA K KG +D + +QQ+ + ++ Q H N D +D +L + P K+ + VN +R SDS +
Sbjct: 335 CHWRSCRIEFITQDELVKHINNDHIQTNKK-AFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSR----HNLQEH-NIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL 567
BLAST of GLI-2 vs. Ensembl Fly
Match: ci (gene:FBgn0004859 transcript:FBtr0089178) HSP 1 Score: 245.358 bits (625), Expect = 1.022e-71 Identity = 127/239 (53.14%), Postives = 155/239 (64.85%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKN---------YTVNEIRNSDSKI 833
CHW SC + + LV HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE+ C+K FSNASDRAKHQNRTHSN+KPY CK GC KRYTDPSSLRKHVKT H + YA K KG +D + +QQ+ + ++ Q H N D +D +L + P K+ + VN +R SDS +
Sbjct: 453 CHWRSCRIEFITQDELVKHINNDHIQTNKK-AFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSR----HNLQEH-NIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL 685
BLAST of GLI-2 vs. Ensembl Fly
Match: lmd (gene:FBgn0039039 transcript:FBtr0084364) HSP 1 Score: 174.096 bits (440), Expect = 2.032e-47 Identity = 88/187 (47.06%), Postives = 117/187 (62.57%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSE 704
C W C ++ + V HI H+ K + C W +C R KPF A+Y L++HMR H+GEKP+KC + C+K +SRLENLK H R+HTGE+PY C++ C K FSN+SDRAKHQ RTH + KPY C++ GC KRYTDPSSLRKHVK NH + +L++ + + K T +SE
Sbjct: 437 CRWTGCDEEFPHQQAFVEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVK-NHALRNANGQLRRKSAGGASVPPSGPKKAAKTRRHSE 621
BLAST of GLI-2 vs. Ensembl Fly
Match: sug (gene:FBgn0033782 transcript:FBtr0331985) HSP 1 Score: 164.081 bits (414), Expect = 5.841e-47 Identity = 80/151 (52.98%), Postives = 101/151 (66.89%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKH-ISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 593
C+W C + + L H+ +H I+ Y C+W C R+++ F A+Y ++VH R HT EKPH+C C+K +SR ENLK HIR+H+GEKPY C F C K +SN+SDR KH RTHS +KPY CKV GC KRYTDPSSLRKHVKT
Sbjct: 68 CNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKH-TRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKT 215
BLAST of GLI-2 vs. Ensembl Fly
Match: sug (gene:FBgn0033782 transcript:FBtr0087789) HSP 1 Score: 164.851 bits (416), Expect = 1.390e-46 Identity = 80/151 (52.98%), Postives = 101/151 (66.89%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKH-ISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 593
C+W C + + L H+ +H I+ Y C+W C R+++ F A+Y ++VH R HT EKPH+C C+K +SR ENLK HIR+H+GEKPY C F C K +SN+SDR KH RTHS +KPY CKV GC KRYTDPSSLRKHVKT
Sbjct: 130 CNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKH-TRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKT 277
BLAST of GLI-2 vs. Ensembl Zebrafish
Match: gli2b (GLI family zinc finger 2b [Source:ZFIN;Acc:ZDB-GENE-050523-1]) HSP 1 Score: 243.432 bits (620), Expect = 4.297e-71 Identity = 110/165 (66.67%), Postives = 129/165 (78.18%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE C+K+ E LV+HI +HI KK ++C+W+ C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 256 CHWEGCSKEYDTQEQLVHHINNEHIHGEKK-EFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 419
BLAST of GLI-2 vs. Ensembl Zebrafish
Match: gli1 (GLI family zinc finger 1 [Source:ZFIN;Acc:ZDB-GENE-030321-1]) HSP 1 Score: 243.432 bits (620), Expect = 7.000e-71 Identity = 110/167 (65.87%), Postives = 130/167 (77.84%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESW 644
CHWESC+K+ E LV+HI +HI KK ++C W +C R ++PFKAQYMLVVHMRRHTGEKPHKC + C+K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K +G++
Sbjct: 304 CHWESCSKEFDTQEQLVHHINNEHIHGEKK-EFVCHWKDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTG 469
BLAST of GLI-2 vs. Ensembl Zebrafish
Match: gli3 (GLI family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-041111-162]) HSP 1 Score: 241.506 bits (615), Expect = 3.563e-70 Identity = 109/167 (65.27%), Postives = 128/167 (76.65%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESW 644
CHW+ C ++ E LV+HI HI KK ++C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++GE++
Sbjct: 488 CHWDGCCREFDTQEQLVHHINNDHIHGEKK-EFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGETY 653
BLAST of GLI-2 vs. Ensembl Zebrafish
Match: gli2a (GLI family zinc finger 2a [Source:ZFIN;Acc:ZDB-GENE-990706-8]) HSP 1 Score: 232.646 bits (592), Expect = 3.581e-67 Identity = 109/166 (65.66%), Postives = 127/166 (76.51%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGES 641
CHWE C K+ + LV+HI HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G++
Sbjct: 408 CHWEGCAKEYDTQDQLVHHISNDHIHGEKKEF-VCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDA 572
BLAST of GLI-2 vs. Ensembl Zebrafish
Match: gli2a (GLI family zinc finger 2a [Source:ZFIN;Acc:ZDB-GENE-990706-8]) HSP 1 Score: 232.646 bits (592), Expect = 3.898e-67 Identity = 109/166 (65.66%), Postives = 127/166 (76.51%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGES 641
CHWE C K+ + LV+HI HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G++
Sbjct: 404 CHWEGCAKEYDTQDQLVHHISNDHIHGEKKEF-VCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDA 568
BLAST of GLI-2 vs. Ensembl Xenopus
Match: GLI1 (GLI family zinc finger 1 [Source:NCBI gene;Acc:100494064]) HSP 1 Score: 244.202 bits (622), Expect = 4.418e-71 Identity = 126/229 (55.02%), Postives = 150/229 (65.50%), Query Frame = 3
Query: 99 ELKNDHGKLSINT---EKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQL--PNLLLK 770
+L+ D GK T CHWESCTK+ E LV+HI +HI KK ++C W +C R +PFKAQYMLVVHMRRHTGEKPHKC + C+K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K +G+ R + T Q+ A ED +L P++ LK
Sbjct: 138 DLEKDDGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGEKK-EFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDGM-PRTQSGHEGSGNHTVKGENQLDMEASSARKEDGRLAVPDITLK 364
BLAST of GLI-2 vs. Ensembl Xenopus
Match: GLI1 (GLI family zinc finger 1 [Source:NCBI gene;Acc:100494064]) HSP 1 Score: 243.817 bits (621), Expect = 5.541e-71 Identity = 126/229 (55.02%), Postives = 150/229 (65.50%), Query Frame = 3
Query: 99 ELKNDHGKLSINT---EKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQL--PNLLLK 770
+L+ D GK T CHWESCTK+ E LV+HI +HI KK ++C W +C R +PFKAQYMLVVHMRRHTGEKPHKC + C+K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K +G+ R + T Q+ A ED +L P++ LK
Sbjct: 234 DLEKDDGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGEKK-EFVCHWQDCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDGM-PRTQSGHEGSGNHTVKGENQLDMEASSARKEDGRLAVPDITLK 460
BLAST of GLI-2 vs. Ensembl Xenopus
Match: cep164 (centrosomal protein 164kDa [Source:Xenbase;Acc:XB-GENE-6035710]) HSP 1 Score: 241.891 bits (616), Expect = 2.921e-70 Identity = 109/165 (66.06%), Postives = 128/165 (77.58%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE C+++ E LV+HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 486 CHWEGCSREFDTQEQLVHHINNDHIHGEKK-EFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 649
BLAST of GLI-2 vs. Ensembl Xenopus
Match: shmt1 (serine hydroxymethyltransferase 1 (soluble) [Source:Xenbase;Acc:XB-GENE-966676]) HSP 1 Score: 228.024 bits (580), Expect = 1.770e-65 Identity = 106/165 (64.24%), Postives = 126/165 (76.36%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHW+ C+ + + LV+HI HI KK + +C+W++C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K + +
Sbjct: 388 CHWDGCSHEFDTQDQLVHHINNDHIHGEKKEF-VCRWHDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCYKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKHRND 551
BLAST of GLI-2 vs. Ensembl Xenopus
Match: shmt1 (serine hydroxymethyltransferase 1 (soluble) [Source:Xenbase;Acc:XB-GENE-966676]) HSP 1 Score: 228.024 bits (580), Expect = 2.052e-65 Identity = 106/165 (64.24%), Postives = 126/165 (76.36%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHW+ C+ + + LV+HI HI KK + +C+W++C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K + +
Sbjct: 403 CHWDGCSHEFDTQDQLVHHINNDHIHGEKKEF-VCRWHDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCYKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKHRND 566
BLAST of GLI-2 vs. Ensembl Mouse
Match: Gli3 (GLI-Kruppel family member GLI3 [Source:MGI Symbol;Acc:MGI:95729]) HSP 1 Score: 235.343 bits (599), Expect = 3.945e-68 Identity = 109/165 (66.06%), Postives = 128/165 (77.58%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE CT++ + LV+HI HI KK + +C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 482 CHWEGCTREFDTQDQLVHHINNDHIHGEKKEF-VCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 645
BLAST of GLI-2 vs. Ensembl Mouse
Match: Gli2 (GLI-Kruppel family member GLI2 [Source:MGI Symbol;Acc:MGI:95728]) HSP 1 Score: 235.343 bits (599), Expect = 5.118e-68 Identity = 110/174 (63.22%), Postives = 128/174 (73.56%), Query Frame = 3
Query: 117 GKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
++ I CHW CTK+ E LV+HI +HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K ++ +
Sbjct: 410 AEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHGEKKEF-VCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRND 582
BLAST of GLI-2 vs. Ensembl Mouse
Match: Gli1 (GLI-Kruppel family member GLI1 [Source:MGI Symbol;Acc:MGI:95727]) HSP 1 Score: 231.876 bits (590), Expect = 4.497e-67 Identity = 107/186 (57.53%), Postives = 130/186 (69.89%), Query Frame = 3
Query: 126 SINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKK 683
S+ C W+ C+++ E LV+HI ++HI +K ++C W C R +PFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE C+K FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K +G+ R + + K
Sbjct: 234 SVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERK-EFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPK 418
BLAST of GLI-2 vs. Ensembl Mouse
Match: Glis3 (GLIS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:2444289]) HSP 1 Score: 182.57 bits (462), Expect = 7.453e-51 Identity = 87/160 (54.37%), Postives = 106/160 (66.25%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEK 623
C W C+ E LV HI HI + K + C W C R KPF A+Y L++HMR H+GEKP+KC + C K +SRLENLK H+R+HTGEKPY C+ C K FSN+SDRAKHQ RTH + KPY C++ GC KRYTDPSSLRKHVK + + A K
Sbjct: 502 CRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQ-RTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARK 660
BLAST of GLI-2 vs. Ensembl Mouse
Match: Glis3 (GLIS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:2444289]) HSP 1 Score: 183.341 bits (464), Expect = 2.437e-50 Identity = 87/160 (54.37%), Postives = 106/160 (66.25%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEK 623
C W C+ E LV HI HI + K + C W C R KPF A+Y L++HMR H+GEKP+KC + C K +SRLENLK H+R+HTGEKPY C+ C K FSN+SDRAKHQ RTH + KPY C++ GC KRYTDPSSLRKHVK + + A K
Sbjct: 502 CRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQ-RTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARK 660
BLAST of GLI-2 vs. UniProt/SwissProt
Match: sp|P19538|CI_DROME (Transcriptional activator cubitus interruptus OS=Drosophila melanogaster OX=7227 GN=ci PE=1 SV=2) HSP 1 Score: 245.358 bits (625), Expect = 1.024e-70 Identity = 127/239 (53.14%), Postives = 155/239 (64.85%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKN---------YTVNEIRNSDSKI 833
CHW SC + + LV HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE+ C+K FSNASDRAKHQNRTHSN+KPY CK GC KRYTDPSSLRKHVKT H + YA K KG +D + +QQ+ + ++ Q H N D +D +L + P K+ + VN +R SDS +
Sbjct: 453 CHWRSCRIEFITQDELVKHINNDHIQTNKK-AFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSR----HNLQEH-NIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL 685
BLAST of GLI-2 vs. UniProt/SwissProt
Match: sp|P55879|GLI2_CHICK (Zinc finger protein GLI2 (Fragment) OS=Gallus gallus OX=9031 GN=GLI2 PE=2 SV=1) HSP 1 Score: 236.884 bits (603), Expect = 2.528e-70 Identity = 110/163 (67.48%), Postives = 125/163 (76.69%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKK 632
CHWE CTK+ E LV+HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K ++
Sbjct: 236 CHWEGCTKEYDTQEQLVHHINNDHIHGEKK-EFVCRWQDCTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR 397
BLAST of GLI-2 vs. UniProt/SwissProt
Match: sp|P10070|GLI2_HUMAN (Zinc finger protein GLI2 OS=Homo sapiens OX=9606 GN=GLI2 PE=1 SV=4) HSP 1 Score: 243.047 bits (619), Expect = 6.437e-70 Identity = 111/174 (63.79%), Postives = 129/174 (74.14%), Query Frame = 3
Query: 117 GKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
++ I CHWE CTK+ E LV+HI +HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + K ++ +
Sbjct: 430 AEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEF-VCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRND 602
BLAST of GLI-2 vs. UniProt/SwissProt
Match: sp|Q9IA31|GLI3_CHICK (Transcriptional activator GLI3 (Fragment) OS=Gallus gallus OX=9031 GN=GLI3 PE=1 SV=1) HSP 1 Score: 242.276 bits (617), Expect = 1.334e-69 Identity = 109/165 (66.06%), Postives = 128/165 (77.58%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE C+++ E LV+HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 484 CHWEGCSREFDTQEQLVHHINNDHIHGEKK-EFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 647
BLAST of GLI-2 vs. UniProt/SwissProt
Match: sp|Q91660|GLI3_XENLA (Zinc finger protein GLI3 OS=Xenopus laevis OX=8355 GN=gli3 PE=2 SV=1) HSP 1 Score: 241.891 bits (616), Expect = 1.563e-69 Identity = 109/165 (66.06%), Postives = 128/165 (77.58%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE C+++ E LV+HI HI KK ++C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 487 CHWEGCSREFDTQEQLVHHINNDHIHGEKK-EFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 650
BLAST of GLI-2 vs. TrEMBL
Match: D2ILS4 (GLI-2 OS=Schmidtea mediterranea OX=79327 GN=gli-2 PE=2 SV=1) HSP 1 Score: 605.905 bits (1561), Expect = 0.000e+0 Identity = 293/297 (98.65%), Postives = 296/297 (99.66%), Query Frame = 3
Query: 297 MLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYKFESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQQHIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL 1187
MLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEF+SCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADI+HLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYK ESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQ+HIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL
Sbjct: 1 MLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFVSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIIHLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYKSESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQRHIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL 297
BLAST of GLI-2 vs. TrEMBL
Match: D0VYP4 (GLI family zinc finger protein OS=Dugesia japonica OX=6161 GN=Djgli PE=2 SV=1) HSP 1 Score: 264.233 bits (674), Expect = 2.157e-76 Identity = 124/171 (72.51%), Postives = 139/171 (81.29%), Query Frame = 3
Query: 144 CHWESCTKQCFDCET-LVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW C K FD ++ LV HI T HIS K +ICQW +C R+ +PFKAQYMLVVHMRRHTGEKPH+C + NC+K YSRLENLKTHIR+HTGEKPY CEF C+K FSNASDRAKHQNRTHSN KPY CKV+GC KRYTDPSSLRKHVKTNH ++YA+K KGESWSDR
Sbjct: 333 CHWNDCAKM-FDTQSELVKHISTIHISGSGKQTFICQWKDCVRSGRPFKAQYMLVVHMRRHTGEKPHQCTFPNCNKRYSRLENLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVEGCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESWSDR 502
BLAST of GLI-2 vs. TrEMBL
Match: D2ILS3 (GLI-1 OS=Schmidtea mediterranea OX=79327 GN=gli-1 PE=2 SV=1) HSP 1 Score: 254.218 bits (648), Expect = 8.426e-73 Identity = 120/171 (70.18%), Postives = 136/171 (79.53%), Query Frame = 3
Query: 144 CHWESCTKQCFDCET-LVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW C K FD + LV HI T HIS K ++CQW +C R+ +PFKAQYMLVVHMRRHT EKPH+C + NC+K YSRLE+LKTHIR+HTGEKPY CEF C+K FSNASDRAKHQNRTHSN KPY CKV+ C KRYTDPSSLRKHVKTNH ++YA+K KGESWSDR
Sbjct: 325 CHWNDCVKT-FDTQAELVKHISTIHISGSGKQTFVCQWKDCVRSGRPFKAQYMLVVHMRRHTSEKPHQCTFPNCNKRYSRLESLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVERCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESWSDR 494
BLAST of GLI-2 vs. TrEMBL
Match: A0A2H1CIU7 (CI protein OS=Fasciola hepatica OX=6192 GN=D915_003540 PE=4 SV=1) HSP 1 Score: 256.529 bits (654), Expect = 4.614e-72 Identity = 119/171 (69.59%), Postives = 132/171 (77.19%), Query Frame = 3
Query: 141 KCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW CT Q + E LV HI +HI+ KK ++C W C R +PFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE C+K FSNASDRAKHQNRTHSN+KPY CKVDGC KRYTDPSSLRKHVKT H ++YA K KGESWSDR
Sbjct: 904 ACHWGECTLQFENQEELVKHISNEHIAGNKK-SFVCLWRECVRGTRPFKAQYMLVVHMRRHTGEKPHKCIFEGCSKRYSRLENLKTHLRSHTGEKPYQCEIPGCHKAFSNASDRAKHQNRTHSNEKPYTCKVDGCSKRYTDPSSLRKHVKTVHGAEVYANKKHKGESWSDR 1073
BLAST of GLI-2 vs. TrEMBL
Match: A0A504Y6J6 (Cubitus interruptus protein OS=Fasciola gigantica OX=46835 GN=FGIG_01644 PE=4 SV=1) HSP 1 Score: 256.529 bits (654), Expect = 5.537e-72 Identity = 119/171 (69.59%), Postives = 132/171 (77.19%), Query Frame = 3
Query: 141 KCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW CT Q + E LV HI +HI+ KK ++C W C R +PFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE C+K FSNASDRAKHQNRTHSN+KPY CKVDGC KRYTDPSSLRKHVKT H ++YA K KGESWSDR
Sbjct: 906 ACHWGECTLQFENQEELVKHISNEHIAGNKK-SFVCLWRECVRGTRPFKAQYMLVVHMRRHTGEKPHKCIFEGCSKRYSRLENLKTHLRSHTGEKPYQCEIPGCHKAFSNASDRAKHQNRTHSNEKPYTCKVDGCSKRYTDPSSLRKHVKTVHGAEVYANKKHKGESWSDR 1075
BLAST of GLI-2 vs. Ensembl Cavefish
Match: gli2a (GLI family zinc finger 2 [Source:NCBI gene;Acc:103029390]) HSP 1 Score: 243.817 bits (621), Expect = 3.528e-71 Identity = 110/166 (66.27%), Postives = 129/166 (77.71%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGES 641
CHWE C+K+ E LV+HI HI KK ++C+W+ C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G++
Sbjct: 397 CHWEGCSKEYDTQEQLVHHINNDHIHGEKK-EFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDA 561
BLAST of GLI-2 vs. Ensembl Cavefish
Match: gli1 (GLI family zinc finger 1 [Source:ZFIN;Acc:ZDB-GENE-030321-1]) HSP 1 Score: 238.81 bits (608), Expect = 2.191e-69 Identity = 111/172 (64.53%), Postives = 132/172 (76.74%), Query Frame = 3
Query: 126 SINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGES 641
+I CHWESC+K+ E LV+HI +HI KK + +C W +C R ++PFKAQYMLVVHMRRHTGEKPHKC + C+K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K +G++
Sbjct: 319 AIYETNCHWESCSKEFDTQEQLVHHINNEHIHGEKKEF-VCHWKDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDT 489
BLAST of GLI-2 vs. Ensembl Cavefish
Match: gli2b (zinc finger protein GLI2-like [Source:NCBI gene;Acc:103028990]) HSP 1 Score: 236.113 bits (601), Expect = 1.643e-68 Identity = 114/183 (62.30%), Postives = 134/183 (73.22%), Query Frame = 3
Query: 99 ELKNDHGKLS---INTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
EL + GK + CHWE C+K+ E LV+HI +HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 387 ELDREEGKQEPEVVYETNCHWEGCSKEYDTQEQLVHHINNEHIHGEKKEF-VCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 568
BLAST of GLI-2 vs. Ensembl Cavefish
Match: gli3 (GLI family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-041111-162]) HSP 1 Score: 233.802 bits (595), Expect = 1.025e-67 Identity = 109/167 (65.27%), Postives = 128/167 (76.65%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESW 644
CHWE+C ++ E LV+HI HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+ +
Sbjct: 460 CHWENCCREFDTQEQLVHHINNDHIHGEKKEF-VCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDVY 625
BLAST of GLI-2 vs. Ensembl Cavefish
Match: glis3 (GLIS family zinc finger 3 [Source:ZFIN;Acc:ZDB-GENE-070112-2232]) HSP 1 Score: 182.185 bits (461), Expect = 7.901e-52 Identity = 87/160 (54.37%), Postives = 107/160 (66.88%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEK 623
C W C E LV HI H+ + K + C W C R KPF A+Y L++HMR H+GEKP+KC + C K +SRLENLK H+R+HTGEKPY C+ C K FSN+SDRAKHQ RTH + KPY C++ GCLKRYTDPSSLRKHVK++ + A K
Sbjct: 306 CRWLDCNATYSHKEELVKHIEKLHMDQRKGEDFTCYWAGCPRRHKPFNARYKLLIHMRVHSGEKPNKCTFEGCQKAFSRLENLKIHLRSHTGEKPYTCQHPGCQKAFSNSSDRAKHQ-RTHIDTKPYACQIQGCLKRYTDPSSLRKHVKSHSTKEQQARK 464
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008614.1 (pep scaffold:Pmarinus_7.0:GL479003:10005:19084:-1 gene:ENSPMAG00000007806.1 transcript:ENSPMAT00000008614.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 204.912 bits (520), Expect = 8.478e-66 Identity = 97/131 (74.05%), Postives = 108/131 (82.44%), Query Frame = 3
Query: 198 HIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
HI +HI +K + +C+W +C R KKPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVK
Sbjct: 1 HINNEHIHGERKEF-VCRWRDCSREKKPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKISGCTKRYTDPSSLRKHVK 130
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Match: glis2b (GLIS family zinc finger 2b [Source:ZFIN;Acc:ZDB-GENE-091204-120]) HSP 1 Score: 156.762 bits (395), Expect = 3.213e-46 Identity = 78/145 (53.79%), Postives = 99/145 (68.28%), Query Frame = 3
Query: 165 KQCFDCE-TLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTN 596
+Q FD + LV H+ H+ ++ Y C W C R + F A+Y +++H+R HT EKPH+C C+K +SRLENLK H R+HTGEKPY C + C+KR+SN+SDR KH RTH KPY CK GCLKRYTDPSSLRKHVK +
Sbjct: 4 QQVFDSQQELVEHVHDAHVRADREVGYCCHWEGCARMGRGFNARYKMLIHVRTHTNEKPHQCPI--CNKSFSRLENLKIHGRSHTGEKPYACPYQGCSKRYSNSSDRFKH-TRTHYVDKPYACKTPGCLKRYTDPSSLRKHVKAH 145
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003448.1 (pep scaffold:Pmarinus_7.0:GL477543:42863:56609:1 gene:ENSPMAG00000003158.1 transcript:ENSPMAT00000003448.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 136.732 bits (343), Expect = 2.958e-39 Identity = 75/157 (47.77%), Postives = 92/157 (58.60%), Query Frame = 3
Query: 126 SINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFS--NASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
S E C WE C E L HI H+ + + CQW CGR ++PF A+Y L++HMR H+GEKP++C C + +S + K R H K C F C K FS N+SDRAKHQ RTH + KPY C+V GC KRYTDPSSLRKHVK
Sbjct: 2 SATGEACRWEECRAAFGRREQLCRHIEKSHVEPQRGEEFACQWEACGRRRRPFNARYKLLIHMRVHSGEKPNRCML--CCETFSHSDTHKHSTRPHQDIKRLQCTFEGCPKAFSRLNSSDRAKHQ-RTHQDTKPYVCQVPGCSKRYTDPSSLRKHVK 155
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003451.1 (pep scaffold:Pmarinus_7.0:GL477543:42884:56609:1 gene:ENSPMAG00000003158.1 transcript:ENSPMAT00000003451.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 134.806 bits (338), Expect = 1.426e-38 Identity = 73/152 (48.03%), Postives = 92/152 (60.53%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCE-FLSCNKRFS--NASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
C WE C E L HI H+ + + CQW CGR ++PF A+Y L++HMR H+GEKP++C S K + L N +T ++ T + C F C K FS N+SDRAKHQ RTH + KPY C+V GC KRYTDPSSLRKHVK
Sbjct: 1 CRWEECRAAFGRREQLCRHIEKSHVEPQRGEEFACQWEACGRRRRPFNARYKLLIHMRVHSGEKPNRCMVSGGSKYHLDLPNWRTRRKSITPSRSAVCRHFEGCPKAFSRLNSSDRAKHQ-RTHQDTKPYVCQVPGCSKRYTDPSSLRKHVK 151
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Match: znf143b (zinc finger protein 143b [Source:NCBI gene;Acc:393954]) HSP 1 Score: 100.908 bits (250), Expect = 8.291e-24 Identity = 68/202 (33.66%), Postives = 95/202 (47.03%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKI--------YAEKLKKGESWSDRINVIQQDKKKP-----TDDYSEQI 710
C E+C K L HI T H E KP+ C + CGR+ F + VH+R HTGE+P+ C C + +S N K H+R HTGEKPY C C KRF+ S KHQ H+ KPY C C K Y PS+L H ++ H + Y ++ + + ++ V+ D P T D ++Q+
Sbjct: 197 CPDETCRKGFKTSGDLQKHIRT-HTGE--KPFK-CPFEGCGRS---FTTSNIRKVHIRTHTGERPYLCPEPGCGRGFSSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHQ-VVHTPVKPYSC--SNCSKTYRQPSTLATHKRSAHGGDVPSKRQRIAYLTGVEGEDGITAQVAVVTHDGLTPQVALITQDGTQQV 388 HSP 2 Score: 97.4413 bits (241), Expect = 1.162e-22 Identity = 53/158 (33.54%), Postives = 79/158 (50.00%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYA 617
C +E C + T +H+ + Y C CG K F Y L H+R HTGEKP+ C C K + +L+ HIRTHTGEKP+ C F C + F+ ++ R H RTH+ ++PY C GC + ++ ++ + HV+ + K Y
Sbjct: 137 CRYEGCGR----LYTTAHHLKVHERAHTGDRPYRCNQPCCG---KAFSTGYGLKSHLRTHTGEKPYLCPDETCRKGFKTSGDLQKHIRTHTGEKPFKCPFEGCGRSFTTSNIRKVHI-RTHTGERPYLCPEPGCGRGFSSATNYKNHVRIHTGEKPYV 286 HSP 3 Score: 75.0998 bits (183), Expect = 4.553e-15 Identity = 36/97 (37.11%), Postives = 51/97 (52.58%), Query Frame = 3
Query: 324 TGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIY 614
+GEK C Y C + Y+ +LK H R HTG++PY C C K FS H RTH+ +KPY C + C K + L+KH++T+ K +
Sbjct: 130 SGEKAFHCRYEGCGRLYTTAHHLKVHERAHTGDRPYRCNQPCCGKAFSTGYGLKSHL-RTHTGEKPYLCPDETCRKGFKTSGDLQKHIRTHTGEKPF 225
BLAST of GLI-2 vs. Ensembl Yeast
Match: ZAP1 (Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [Source:SGD;Acc:S000003592]) HSP 1 Score: 100.523 bits (249), Expect = 2.816e-23 Identity = 58/150 (38.67%), Postives = 86/150 (57.33%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 593
C W+ C K + L +H+ H++ K Y C W++C R F + L+ H++ H+ KP+KC+ C +C+S E L H RTH+GEKPY C CNK+F+ +S H RTH+ +KP CK+ C KR+ + S+L KH+KT
Sbjct: 707 CQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQ-CLWHDCHRT---FPQRQKLIRHLKVHSKYKPYKCK--TCKRCFSSEETLVQHTRTHSGEKPYKCHI--CNKKFAISSSLKIHI-RTHTGEKPLQCKI--CGKRFNESSNLSKHIKT 845 HSP 2 Score: 65.0846 bits (157), Expect = 8.001e-12 Identity = 44/131 (33.59%), Postives = 73/131 (55.73%), Query Frame = 3
Query: 216 ISECKKP-YYICQWNNCGRNKKPFKAQ----YMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 593
I K+P ICQW+ C NK AQ ++ VH+ R G+ ++C + +C + + + + L H++ H+ KPY C+ +C + FS+ +H RTHS +KPY C + C K++ SSL+ H++T
Sbjct: 696 IPPIKQPEQVICQWDGC--NKSFSSAQELNDHLEAVHLTR--GKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCK--TCKRCFSSEETLVQH-TRTHSGEKPYKCHI--CNKKFAISSSLKIHIRT 817
BLAST of GLI-2 vs. Ensembl Yeast
Match: AZF1 (Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000005639]) HSP 1 Score: 81.2629 bits (199), Expect = 4.959e-17 Identity = 46/119 (38.66%), Postives = 65/119 (54.62%), Query Frame = 3
Query: 282 FKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
F L VH+R H G KP C+Y C K +++ NL+TH R HTGEKPY+C+ C+K+FS + A H TH KP+ CK++ C K +T +++ H H + A K E
Sbjct: 602 FSQATHLEVHVRSHIGYKPFVCDY--CGKRFTQGGNLRTHERLHTGEKPYSCDI--CDKKFSRKGNLAAHL-VTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAE 715 HSP 2 Score: 68.5514 bits (166), Expect = 6.562e-13 Identity = 37/89 (41.57%), Postives = 49/89 (55.06%), Query Frame = 3
Query: 240 YICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTH 506
++C + CG K F L H R HTGEKP+ C+ CDK +SR NL H+ TH KP+ C+ +CNK F+ + HQNR H
Sbjct: 621 FVCDY--CG---KRFTQGGNLRTHERLHTGEKPYSCDI--CDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFH 702 HSP 3 Score: 60.8474 bits (146), Expect = 2.128e-10 Identity = 33/99 (33.33%), Postives = 58/99 (58.59%), Query Frame = 3
Query: 333 KPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLK 629
K H+C Y C + +S+ +L+ H+R+H G KP+ C++ C KRF+ + H+ R H+ +KPY C + C K+++ +L H+ T+ K + KL+
Sbjct: 591 KKHECPY--CHRLFSQATHLEVHVRSHIGYKPFVCDY--CGKRFTQGGNLRTHE-RLHTGEKPYSCDI--CDKKFSRKGNLAAHLVTHQKLKPFVCKLE 682
BLAST of GLI-2 vs. Ensembl Yeast
Match: MIG2 (Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose [Source:SGD;Acc:S000003177]) HSP 1 Score: 59.6918 bits (143), Expect = 2.236e-10 Identity = 29/61 (47.54%), Postives = 39/61 (63.93%), Query Frame = 3
Query: 333 KPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQ 515
+P +C+ C + + RLE+ K H+RTHTGEKP++C F C K FS SD K RTH+ Q
Sbjct: 15 RPFRCD--TCHRGFHRLEHKKRHLRTHTGEKPHHCAFPGCGKSFSR-SDELKRHMRTHTGQ 72 HSP 2 Score: 58.151 bits (139), Expect = 7.956e-10 Identity = 29/70 (41.43%), Postives = 38/70 (54.29%), Query Frame = 3
Query: 309 HMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNC--------EFLSCNKRFSNASDRAKHQ 494
H+R HTGEKPH C + C K +SR + LK H+RTHTG+ EFL+ + + AS HQ
Sbjct: 35 HLRTHTGEKPHHCAFPGCGKSFSRSDELKRHMRTHTGQSQRRLKKASVQKQEFLTVSGIPTIASGVMIHQ 104
BLAST of GLI-2 vs. Ensembl Yeast
Match: MIG1 (Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state [Source:SGD;Acc:S000003003]) HSP 1 Score: 60.077 bits (144), Expect = 2.306e-10 Identity = 34/101 (33.66%), Postives = 53/101 (52.48%), Query Frame = 3
Query: 225 CKKPYYICQWNNC--GRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKP 521
+ PY + Q +N G K K++ + + +PH C C + + RLE+ H+R HTGEKP+ C+F C KRFS + + +H+ R H+N P
Sbjct: 1 MQSPYPMTQVSNVDDGSLLKESKSKSKVAA---KSEAPRPHACPI--CHRAFHRLEHQTRHMRIHTGEKPHACDFPGCVKRFSRSDELTRHR-RIHTNSHP 95
BLAST of GLI-2 vs. Ensembl Yeast
Match: CRZ1 (Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium [Source:SGD;Acc:S000004972]) HSP 1 Score: 57.7658 bits (138), Expect = 1.661e-9 Identity = 31/85 (36.47%), Postives = 47/85 (55.29%), Query Frame = 3
Query: 360 CDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVD-------GCLKRYTDPSSLRKHVKT 593
C K ++R NLK+H+RTHT E+P+ C C K F+ DR +H++ H+ +K Y C GC K++ +L +H KT
Sbjct: 574 CGKKFTRPYNLKSHLRTHTNERPFICSI--CGKAFARQHDRKRHED-LHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKT 655
BLAST of GLI-2 vs. Ensembl Nematostella
Match: EDO37573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFG3]) HSP 1 Score: 204.912 bits (520), Expect = 4.947e-65 Identity = 99/154 (64.29%), Postives = 115/154 (74.68%), Query Frame = 3
Query: 147 HWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNK 608
HW+ CT ++LV H+ HI + K+ + C W +C R ++PFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGE+PY CE C K FSNASDRAKHQNRTHS+ KPY CKV GC KRYTDPSSLRKH KT H +
Sbjct: 2 HWKDCTIVFDSQDSLVKHVNGDHIKKEKRDF-TCYWQDCSREQRPFKAQYMLVVHMRRHTGEKPHKCYHEGCTKAYSRLENLKTHLRSHTGERPYVCEVEGCTKAFSNASDRAKHQNRTHSSVKPYVCKVPGCPKRYTDPSSLRKHTKTVHGEQ 154
BLAST of GLI-2 vs. Ensembl Nematostella
Match: EDO44435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVR5]) HSP 1 Score: 182.57 bits (462), Expect = 4.057e-56 Identity = 87/161 (54.04%), Postives = 113/161 (70.19%), Query Frame = 3
Query: 138 EKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAE 620
++C WESC + LVNH+ HI+ K Y C+W C RN K F A+Y +++HMR HTGE+PHKC + +C+K +SRLENLK H R+HTGEKPY+C C+KR+SN+SDR KH RTH +KPY C+++GC KRYTDPSSLRKH+KT H + E
Sbjct: 17 QQCKWESCCHHFLTLDDLVNHVNEYHITFDKDSEYRCRWQGCNRNGKGFNARYKMLIHMRTHTGERPHKCTFDSCEKSFSRLENLKIHQRSHTGEKPYSCPIEGCDKRYSNSSDRFKH-TRTHYERKPYHCRIEGCEKRYTDPSSLRKHLKTYHGQESSIE 176
BLAST of GLI-2 vs. Ensembl Nematostella
Match: EDO45177 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU02]) HSP 1 Score: 174.096 bits (440), Expect = 2.374e-53 Identity = 88/150 (58.67%), Postives = 105/150 (70.00%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKP-YYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
C W C + + LV HI HI + K YIC W +C R KPF A+Y LV+HMR H+GEKP+KC + C+K +SRLENLK H+R+HTGEKPY C+F C K FSN+SDRAKHQ RTH + KPY C+V GC KRYTDPSSLRKH K
Sbjct: 2 CRWLGCDAVYSEQDDLVRHIEKVHIDQRKADDLYICYWQDCSRQTKPFNARYKLVIHMRVHSGEKPNKCTHPGCNKAFSRLENLKIHMRSHTGEKPYLCQFPGCPKAFSNSSDRAKHQ-RTHLDTKPYACQVPGCPKRYTDPSSLRKHFK 150
BLAST of GLI-2 vs. Ensembl Nematostella
Match: NV-ZICC (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK36]) HSP 1 Score: 166.392 bits (420), Expect = 6.022e-49 Identity = 84/199 (42.21%), Postives = 116/199 (58.29%), Query Frame = 3
Query: 159 CTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTN---HDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNA--DIMHLE 740
C +Q F +V H+ H+ + ++C W +C RN PFKA+Y L+ H+R HTGEKP C + C K ++R ENLK H RTHTGEKP+ CEF C++RF+N+SDR KH + H++ KPY CKVDGC K YT PSSLRKH+K + D+ + + G S N P ++ +I + D H+E
Sbjct: 43 CGRQFFRMHDIVAHLSEDHVGGPESTTHVCYWKDCARNGLPFKAKYKLINHIRVHTGEKPFACPFPGCGKLFARSENLKIHKRTHTGEKPFICEFPGCDRRFANSSDRKKHSH-VHTSDKPYICKVDGCNKSYTHPSSLRKHMKLHSKPSDSGVGSPSDDGGSSAKTSPNFPSASTYPPMSEWFNRIPGSTHHDHFHME 240
BLAST of GLI-2 vs. Ensembl Nematostella
Match: NV-ZICD (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK35]) HSP 1 Score: 162.925 bits (411), Expect = 1.548e-48 Identity = 78/144 (54.17%), Postives = 99/144 (68.75%), Query Frame = 3
Query: 159 CTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
C KQ +V+HI +H+S ++C W C RN +PFKA+Y LV H+R HTGEKP C + C K ++R ENLK H RTHTGEKP+ CEF C++RF+N+SDR KH + H++ KPY CKVDGC K YT PSSLRKH+K
Sbjct: 34 CGKQYTHMPDIVSHISDEHVSANDSSLHVCYWQECSRNGQPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKLFARSENLKIHKRTHTGEKPFMCEFPGCDRRFANSSDRKKHSH-VHTSDKPYICKVDGCNKSYTHPSSLRKHMK 176
BLAST of GLI-2 vs. Ensembl Medaka
Match: gli3 (GLI family zinc finger 3 [Source:NCBI gene;Acc:101167154]) HSP 1 Score: 239.195 bits (609), Expect = 1.934e-69 Identity = 109/165 (66.06%), Postives = 126/165 (76.36%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE+C ++ E LV HI HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 486 CHWENCCREFDTQEQLVQHINNDHIHGEKKEF-VCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 649
BLAST of GLI-2 vs. Ensembl Medaka
Match: gli3 (GLI family zinc finger 3 [Source:NCBI gene;Acc:101167154]) HSP 1 Score: 239.195 bits (609), Expect = 1.934e-69 Identity = 109/165 (66.06%), Postives = 126/165 (76.36%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
CHWE+C ++ E LV HI HI KK + +C+W C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++G+
Sbjct: 486 CHWENCCREFDTQEQLVQHINNDHIHGEKKEF-VCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD 649
BLAST of GLI-2 vs. Ensembl Medaka
Match: gli2b (GLI family zinc finger 2 [Source:NCBI gene;Acc:101164961]) HSP 1 Score: 233.417 bits (594), Expect = 1.379e-67 Identity = 114/193 (59.07%), Postives = 137/193 (70.98%), Query Frame = 3
Query: 81 QYSIIMELKNDHGKLSINTE-------KCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
Q S +++LK D + E CHWE C+K+ + LV+HI HI KK + +C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++ +
Sbjct: 368 QQSSLLDLKEDVDRDEYKQEPEAVYETNCHWEGCSKEYDTQDQLVHHINNDHIHGEKKEF-VCRWEDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRSD 559
BLAST of GLI-2 vs. Ensembl Medaka
Match: gli2b (GLI family zinc finger 2 [Source:NCBI gene;Acc:101164961]) HSP 1 Score: 233.417 bits (594), Expect = 1.379e-67 Identity = 114/193 (59.07%), Postives = 137/193 (70.98%), Query Frame = 3
Query: 81 QYSIIMELKNDHGKLSINTE-------KCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGE 638
Q S +++LK D + E CHWE C+K+ + LV+HI HI KK + +C+W +C R +KPFKAQYMLVVHMRRHTGEKPHKC + C K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K ++ +
Sbjct: 368 QQSSLLDLKEDVDRDEYKQEPEAVYETNCHWEGCSKEYDTQDQLVHHINNDHIHGEKKEF-VCRWEDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRSD 559
BLAST of GLI-2 vs. Ensembl Medaka
Match: gli1 (GLI family zinc finger 1 [Source:NCBI gene;Acc:101163893]) HSP 1 Score: 231.106 bits (588), Expect = 1.025e-66 Identity = 108/166 (65.06%), Postives = 127/166 (76.51%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGES 641
C WESC K+ + LV+HI +HI KK + +C W C R ++PFKAQYMLVVHMRRHTGEKPHKC + C+K YSRLENLKTH+R+HTGEKPY CE CNK FSNASDRAKHQNRTHSN+KPY CK+ GC KRYTDPSSLRKHVKT H + + K +G++
Sbjct: 321 CRWESCNKEFDTQDQLVHHINNEHIHGEKKEF-VCHWQECSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDT 485
BLAST of GLI-2 vs. Planmine SMEST
Match: SMESG000060276.1 (SMESG000060276.1) HSP 1 Score: 754.592 bits (1947), Expect = 0.000e+0 Identity = 364/364 (100.00%), Postives = 364/364 (100.00%), Query Frame = 3
Query: 96 MELKNDHGKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYKFESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQQHIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL 1187
MELKNDHGKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYKFESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQQHIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL
Sbjct: 1 MELKNDHGKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDRINVIQQDKKKPTDDYSEQIHCNADIMHLEDDQLPNLLLKLTDPIWKNYTVNEIRNSDSKIKSSFPQSAFIPFPESYKFESLPLGNFPLNYYQNMNNHVEYHSNQYNPNITVNYTQQHIYNQKDPTLCQCNICTKYKSSQQFNQYQLDVHNSYNSDYWIRNFDIYNNITDSYVYSTNNL 364
BLAST of GLI-2 vs. Planmine SMEST
Match: SMESG000073727.1 (SMESG000073727.1) HSP 1 Score: 262.692 bits (670), Expect = 1.475e-79 Identity = 123/171 (71.93%), Postives = 138/171 (80.70%), Query Frame = 3
Query: 144 CHWESCTKQCFDCET-LVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW C K FD + LV HI T HIS K ++CQW +C R+ +PFKAQYMLVVHMRRHTGEKPH+C + NC+K YSRLENLKTHIR+HTGEKPY CEF C+K FSNASDRAKHQNRTHSN KPY CKV+GC KRYTDPSSLRKHVKTNH ++YA+K KGESWSDR
Sbjct: 303 CHWNDCVKT-FDTQAELVKHISTIHISGSGKQTFVCQWKDCVRSGRPFKAQYMLVVHMRRHTGEKPHQCTFPNCNKRYSRLENLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVEGCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESWSDR 472
BLAST of GLI-2 vs. Planmine SMEST
Match: SMESG000073727.1 (SMESG000073727.1) HSP 1 Score: 262.692 bits (670), Expect = 1.818e-79 Identity = 123/171 (71.93%), Postives = 138/171 (80.70%), Query Frame = 3
Query: 144 CHWESCTKQCFDCET-LVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKTNHDNKIYAEKLKKGESWSDR 653
CHW C K FD + LV HI T HIS K ++CQW +C R+ +PFKAQYMLVVHMRRHTGEKPH+C + NC+K YSRLENLKTHIR+HTGEKPY CEF C+K FSNASDRAKHQNRTHSN KPY CKV+GC KRYTDPSSLRKHVKTNH ++YA+K KGESWSDR
Sbjct: 325 CHWNDCVKT-FDTQAELVKHISTIHISGSGKQTFVCQWKDCVRSGRPFKAQYMLVVHMRRHTGEKPHQCTFPNCNKRYSRLENLKTHIRSHTGEKPYECEFPGCHKAFSNASDRAKHQNRTHSNTKPYVCKVEGCAKRYTDPSSLRKHVKTNHGPQVYADKKMKGESWSDR 494
BLAST of GLI-2 vs. Planmine SMEST
Match: SMESG000078300.1 (SMESG000078300.1) HSP 1 Score: 189.889 bits (481), Expect = 1.908e-53 Identity = 89/151 (58.94%), Postives = 109/151 (72.19%), Query Frame = 3
Query: 144 CHWESCTKQCFDCETLVNHIFTKHISECK-KPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVKT 593
C W C + DC++LVNHI H+ + K Y C W C R KPF A+Y L++HMR H+GEKP+KC+YS CDK +SRLENLK H R+HTGE+PY C+++ C K FSN+SDRAKHQ RTH + KPY C V GC KRYTDPSSLRKH K+
Sbjct: 389 CFWIDCYQSFHDCKSLVNHIEKMHVDQRNIKDEYTCFWQGCSRKLKPFNARYKLLIHMRVHSGEKPNKCKYSGCDKAFSRLENLKIHERSHTGERPYQCQYIGCPKAFSNSSDRAKHQ-RTHYDTKPYCCGVAGCGKRYTDPSSLRKHTKS 538
BLAST of GLI-2 vs. Planmine SMEST
Match: SMESG000052644.1 (SMESG000052644.1) HSP 1 Score: 162.54 bits (410), Expect = 4.390e-45 Identity = 75/145 (51.72%), Postives = 101/145 (69.66%), Query Frame = 3
Query: 156 SCTKQCFDCETLVNHIFTKHISECKKPYYICQWNNCGRNKKPFKAQYMLVVHMRRHTGEKPHKCEYSNCDKCYSRLENLKTHIRTHTGEKPYNCEFLSCNKRFSNASDRAKHQNRTHSNQKPYFCKVDGCLKRYTDPSSLRKHVK 590
+C K + +VNH+ H+ ++ + C W NC R+ KPFKA+Y LV H+R HTGEKP +C + +C K ++R ENLK H RTHTGEKP+ C+F C++RF+N+SDR KH + H N KPYFCK +GC K YT PSSLRKH++
Sbjct: 194 TCGKLFYTINEIVNHLTLDHVGGPEQLDHTCYWKNCTRDFKPFKAKYKLVNHLRVHTGEKPFQCPFLSCGKLFARSENLKIHKRTHTGEKPFKCDFEGCDRRFANSSDRKKHMH-VHMNDKPYFCKQEGCDKSYTHPSSLRKHMR 337 The following BLAST results are available for this feature:
BLAST of GLI-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of GLI-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of GLI-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of GLI-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of GLI-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of GLI-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of GLI-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of GLI-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30015613 ID=SMED30015613|Name=GLI-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1232bpback to top protein sequence of SMED30015613-orf-1 >SMED30015613-orf-1 ID=SMED30015613-orf-1|Name=SMED30015613-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=365bp MELKNDHGKLSINTEKCHWESCTKQCFDCETLVNHIFTKHISECKKPYYIback to top Aliases
The feature 'GLI-2' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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