6-pyruvoyl tetrahydrobiopterin synthase

Overview
Name6-pyruvoyl tetrahydrobiopterin synthase
Smed IDSMED30015421
Length (bp)602
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of 6-pyruvoyl tetrahydrobiopterin synthase (SMED30015421) t-SNE clustered cells

Violin plots show distribution of expression levels for 6-pyruvoyl tetrahydrobiopterin synthase (SMED30015421) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 6-pyruvoyl tetrahydrobiopterin synthase (SMED30015421) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for 6-pyruvoyl tetrahydrobiopterin synthase (SMED30015421) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015421

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30015421SMESG000077201.1 dd_Smed_v4_3156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015421SMESG000077201.1 Contig35591newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015421SMESG000077201.1 Contig35591uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30015421SMESG000077201.1 OX_Smed_1.0.04902ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Match: PTS (6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:HGNC:9689])

HSP 1 Score: 150.214 bits (378), Expect = 5.140e-46
Identity = 73/134 (54.48%), Postives = 98/134 (73.13%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            ++R   FSA+HRL++  LS  EN KLFGKCN+PNGHGHNYK+ VT+   +D +TG+  NL  LK  +++ +M  LDH+++D+DV YF D  +VSTTEN+AV+IW  LQ  L  G+LYKV ++ETD N  VYKGE
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFAD--VVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE 145
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Match: PTS (6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:HGNC:9689])

HSP 1 Score: 82.4185 bits (202), Expect = 2.186e-20
Identity = 41/79 (51.90%), Postives = 56/79 (70.89%), Query Frame = 1 
Query:  253 LCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            +  NL  LK  +++ +M  LDH+++D+DV YF D  +VSTTEN+AV+IW  LQ  L  G+LYKV ++ETD N  VYKGE
Sbjct:    1 MVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFAD--VVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE 77
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Match: PTS (6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:HGNC:9689])

HSP 1 Score: 59.3066 bits (142), Expect = 1.019e-11
Identity = 27/41 (65.85%), Postives = 33/41 (80.49%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYK 210
            ++R   FSA+HRL++  LS  EN KLFGKCN+PNGHGHNYK
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYK 54
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Match: PTS (6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:HGNC:9689])

HSP 1 Score: 59.3066 bits (142), Expect = 1.019e-11
Identity = 27/41 (65.85%), Postives = 33/41 (80.49%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYK 210
            ++R   FSA+HRL++  LS  EN KLFGKCN+PNGHGHNYK
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYK 54
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Match: PTS (6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:HGNC:9689])

HSP 1 Score: 58.9214 bits (141), Expect = 1.333e-11
Identity = 27/41 (65.85%), Postives = 33/41 (80.49%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYK 210
            ++R   FSA+HRL++  LS  EN KLFGKCN+PNGHGHNYK
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYK 54
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Celegans
Match: ptps-1 (Putative 6-pyruvoyl tetrahydrobiopterin synthase [Source:UniProtKB/Swiss-Prot;Acc:O02058])

HSP 1 Score: 134.806 bits (338), Expect = 2.003e-40
Identity = 67/142 (47.18%), Postives = 99/142 (69.72%), Query Frame = 1 
Query:   64 MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGN-GILYKVVLHETDKNKFVYKG 486
            M   PIV + R++ FSAAHRLH+  LS +EN++ FGKCN+ NGHGHNY  +V +R  VD ++G+ Y+L  LK  +   V+  +DHR++D DV +F+    VST+EN+A++++ +L+S + N  +LYKV + ET KN F YKG
Sbjct:    1 MFRMPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSGMVYDLAKLKKEM-SLVLDTVDHRNLDKDVEFFK--TTVSTSENVAIYMFEKLKSVMSNPSVLYKVTIEETPKNIFTYKG 139
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Celegans
Match: ptps-1 (Putative 6-pyruvoyl tetrahydrobiopterin synthase [Source:UniProtKB/Swiss-Prot;Acc:O02058])

HSP 1 Score: 134.42 bits (337), Expect = 2.085e-40
Identity = 66/138 (47.83%), Postives = 98/138 (71.01%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGN-GILYKVVLHETDKNKFVYKG 486
            PIV + R++ FSAAHRLH+  LS +EN++ FGKCN+ NGHGHNY  +V +R  VD ++G+ Y+L  LK  +   V+  +DHR++D DV +F+    VST+EN+A++++ +L+S + N  +LYKV + ET KN F YKG
Sbjct:    2 PIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSGMVYDLAKLKKEM-SLVLDTVDHRNLDKDVEFFK--TTVSTSENVAIYMFEKLKSVMSNPSVLYKVTIEETPKNIFTYKG 136
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Fly
Match: pr (gene:FBgn0003141 transcript:FBtr0089395)

HSP 1 Score: 148.673 bits (374), Expect = 2.090e-45
Identity = 71/142 (50.00%), Postives = 101/142 (71.13%), Query Frame = 1 
Query:   64 MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNG-ILYKVVLHETDKNKFVYKG 486
            M+  P+ +LTR E FSA HRLH+P LS +EN ++FGKCN+ +GHGHNY +E+T+R P+D+ TG+  N+  LK AI+  +M  LDH+++D DV YF +    STTENLAV+IW  ++ +L    +LY+V +HET KN   Y+G
Sbjct:    1 MSQQPVAFLTRRETFSACHRLHSPQLSDAENLEVFGKCNNFHGHGHNYTVEITVRGPIDRRTGMVLNITELKEAIETVIMKRLDHKNLDKDVEYFANTP--STTENLAVYIWDNIRLQLKKPELLYEVKIHETPKNIISYRG 140
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Zebrafish
Match: pts (6-pyruvoyltetrahydropterin synthase [Source:ZFIN;Acc:ZDB-GENE-070615-3])

HSP 1 Score: 131.724 bits (330), Expect = 4.639e-39
Identity = 64/137 (46.72%), Postives = 95/137 (69.34%), Query Frame = 1 
Query:   79 IVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            + ++TR+  FSA HRLH+  LS  EN++ FGKCN+PNGHGHNY   ++++  ++ +  +  N  ++   IK+ VM  LDH+++DLDV YF D  +VSTTENL+VFIW  LQ  L +  LY++ ++ET KN  +Y+GE
Sbjct:    5 VAFITRVCSFSACHRLHSKCLSDEENKRTFGKCNNPNGHGHNYTGFISVQGKIECNIFINLNTCAIGELIKEAVMKPLDHKNLDLDVPYFAD--VVSTTENLSVFIWDGLQKLLPHDSLYEIKVYETAKNIVIYRGE 139
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Zebrafish
Match: CABZ01058222.1 (pep chromosome:GRCz11:12:292452:330202:1 gene:ENSDARG00000113674.1 transcript:ENSDART00000189944.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CABZ01058222.1)

HSP 1 Score: 51.6026 bits (122), Expect = 3.203e-8
Identity = 35/138 (25.36%), Postives = 66/138 (47.83%), Query Frame = 1 
Query:   79 IVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLC-YNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            I Y++ +  FS   R  N    +   ++ F +C   N H H +   V+ ++ + ++  L   N  ++    K +++  LDH+ +  DV YF      STTE++ V++W  ++  L N  L+ +  +    N   Y+GE
Sbjct:    4 ICYISEVCMFSPCWRGPNTCAIVEHKRRYFEECWGENTHSHTHTRFVSEQEKIKRNLILNNPNTCAIGELAKFSILNPLDHKELMCDVLYFSIHR--STTEHILVYVWGGIRQFLNNVSLFSISCYGVSVNITNYRGE 139
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Xenopus
Match: ENSXETT00000025579.1 (6-pyruvoyltetrahydropterin synthase [Source:NCBI gene;Acc:100487259])

HSP 1 Score: 155.606 bits (392), Expect = 7.488e-48
Identity = 70/137 (51.09%), Postives = 101/137 (73.72%), Query Frame = 1 
Query:   79 IVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            I+ ++R   FSA+HRLH+  LS  EN+++FGKCN+PNGHGHNYK+ +T+R  +D +TG+  NL  LK  +++ +   LDH+++D DV YFR+  +VST EN+ VFIW +LQ +L  G+LY+V +HETD N  VY+GE
Sbjct:   36 IIQISRGLSFSASHRLHSNSLSEEENKRIFGKCNNPNGHGHNYKVIITVRGKIDPTTGMVINLTDLKKYMEECITVPLDHKNVDKDVPYFRN--VVSTVENITVFIWEELQKRLPAGLLYEVCVHETDSNSAVYRGE 170
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Xenopus
Match: ENSXETT00000025583.1 (6-pyruvoyltetrahydropterin synthase [Source:NCBI gene;Acc:100487259])

HSP 1 Score: 90.8929 bits (224), Expect = 1.712e-23
Identity = 41/85 (48.24%), Postives = 60/85 (70.59%), Query Frame = 1 
Query:  235 VDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            +D +TG+  NL  LK  +++ +   LDH+++D DV YFR+  +VST EN+ VFIW +LQ +L  G+LY+V +HETD N  VY+GE
Sbjct:    9 IDPTTGMVINLTDLKKYMEECITVPLDHKNVDKDVPYFRN--VVSTVENITVFIWEELQKRLPAGLLYEVCVHETDSNSAVYRGE 91
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Mouse
Match: Pts (6-pyruvoyl-tetrahydropterin synthase [Source:MGI Symbol;Acc:MGI:1338783])

HSP 1 Score: 149.828 bits (377), Expect = 3.942e-46
Identity = 73/129 (56.59%), Postives = 92/129 (71.32%), Query Frame = 1 
Query:  103 QFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
             FSA+HRLH+P LS  EN ++FGKCN+PNGHGHNYK+ VT+   +D  TG+  NL  LK  +++ +M  LDH+++DLDV YF D   VSTTEN+AV+IW  LQ  L  G LYKV + ETD N  VYKGE
Sbjct:   18 SFSASHRLHSPSLSDEENLRVFGKCNNPNGHGHNYKVVVTVHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADA--VSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE 144
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Mouse
Match: Pts (6-pyruvoyl-tetrahydropterin synthase [Source:MGI Symbol;Acc:MGI:1338783])

HSP 1 Score: 80.1073 bits (196), Expect = 1.150e-19
Identity = 42/79 (53.16%), Postives = 53/79 (67.09%), Query Frame = 1 
Query:  253 LCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            +  NL  LK  +++ +M  LDH+++DLDV YF D   VSTTEN+AV+IW  LQ  L  G LYKV + ETD N  VYKGE
Sbjct:    1 MVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADA--VSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE 77
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Mouse
Match: Pts (6-pyruvoyl-tetrahydropterin synthase [Source:MGI Symbol;Acc:MGI:1338783])

HSP 1 Score: 80.1073 bits (196), Expect = 1.150e-19
Identity = 42/79 (53.16%), Postives = 53/79 (67.09%), Query Frame = 1 
Query:  253 LCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            +  NL  LK  +++ +M  LDH+++DLDV YF D   VSTTEN+AV+IW  LQ  L  G LYKV + ETD N  VYKGE
Sbjct:    1 MVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADA--VSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE 77
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Match: sp|P27213|PTPS_RAT (6-pyruvoyl tetrahydrobiopterin synthase OS=Rattus norvegicus OX=10116 GN=Pts PE=1 SV=1)

HSP 1 Score: 154.836 bits (390), Expect = 4.162e-47
Identity = 75/129 (58.14%), Postives = 94/129 (72.87%), Query Frame = 1 
Query:  103 QFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
             FSA+HRLH+P LS  EN K+FGKCN+PNGHGHNYK+ VTI   +D  TG+  NL  LK  +++ +M  LDH+++DLDV YF D  +VSTTEN+AV+IW  LQ  L  G LYKV ++ETD N  VYKGE
Sbjct:   18 SFSASHRLHSPSLSAEENLKVFGKCNNPNGHGHNYKVVVTIHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFAD--VVSTTENVAVYIWENLQRLLPVGALYKVKVYETDNNIVVYKGE 144
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Match: sp|Q90W95|PTPS_POERE (6-pyruvoyl tetrahydrobiopterin synthase OS=Poecilia reticulata OX=8081 GN=pts PE=2 SV=1)

HSP 1 Score: 154.451 bits (389), Expect = 5.932e-47
Identity = 72/137 (52.55%), Postives = 99/137 (72.26%), Query Frame = 1 
Query:   79 IVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            I Y+TR++ FSA HRLH+  LS  EN++++GKCN+P GHGHNYK+EVT+R  +D  TG+  NL  LK  I++ +M  LDH+++D DV YF D  +VSTTENLAV+IW  +   L   + Y++ +HETDKN  VY+GE
Sbjct:   13 IGYITRVQSFSACHRLHSLRLSDEENKEVYGKCNNPYGHGHNYKVEVTVRGKIDPVTGMVMNLTDLKKCIEEVIMIPLDHKNLDKDVPYFAD--VVSTTENLAVYIWDNMAKALPASLPYEIRIHETDKNIVVYRGE 147
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Match: sp|Q03393|PTPS_HUMAN (6-pyruvoyl tetrahydrobiopterin synthase OS=Homo sapiens OX=9606 GN=PTS PE=1 SV=1)

HSP 1 Score: 150.214 bits (378), Expect = 2.468e-45
Identity = 73/134 (54.48%), Postives = 98/134 (73.13%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            ++R   FSA+HRL++  LS  EN KLFGKCN+PNGHGHNYK+ VT+   +D +TG+  NL  LK  +++ +M  LDH+++D+DV YF D  +VSTTEN+AV+IW  LQ  L  G+LYKV ++ETD N  VYKGE
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFAD--VVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE 145
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Match: sp|Q9R1Z7|PTPS_MOUSE (6-pyruvoyl tetrahydrobiopterin synthase OS=Mus musculus OX=10090 GN=Pts PE=1 SV=2)

HSP 1 Score: 149.828 bits (377), Expect = 2.757e-45
Identity = 73/129 (56.59%), Postives = 92/129 (71.32%), Query Frame = 1 
Query:  103 QFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
             FSA+HRLH+P LS  EN ++FGKCN+PNGHGHNYK+ VT+   +D  TG+  NL  LK  +++ +M  LDH+++DLDV YF D   VSTTEN+AV+IW  LQ  L  G LYKV + ETD N  VYKGE
Sbjct:   18 SFSASHRLHSPSLSDEENLRVFGKCNNPNGHGHNYKVVVTVHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADA--VSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE 144
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Match: sp|Q5REZ5|PTPS_PONAB (6-pyruvoyl tetrahydrobiopterin synthase OS=Pongo abelii OX=9601 GN=PTS PE=2 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 4.443e-45
Identity = 73/134 (54.48%), Postives = 98/134 (73.13%), Query Frame = 1 
Query:   88 LTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            ++R   FSA+HRL++  LS  EN KLFGKC++PNGHGHNYK+ VT+   +D +TG+  NL  LK  +++ +M  LDH+++D+DV YF D  +VSTTEN+AV+IW  LQ  L  G+LYKV L+ETD N  VYKGE
Sbjct:   14 VSRRISFSASHRLYSKFLSDEENLKLFGKCSNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFAD--VVSTTENVAVYIWDNLQKVLPVGVLYKVKLYETDNNIVVYKGE 145
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Match: A0A087TID1 (6-pyruvoyl tetrahydrobiopterin synthase (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_25696 PE=4 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 1.668e-53
Identity = 80/139 (57.55%), Postives = 110/139 (79.14%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGEL 492
            P+VYLTRIE FSA+HRLH+PHLS  +N++++GKCN+PNGHGHNYK+EVT++  VDK TG+  N+  LK  IK ++M  LDH+++D DV +F++  +VSTTENL++FIW QL S L +G+LY+V +HETDKN   + GE 
Sbjct:    8 PVVYLTRIETFSASHRLHSPHLSEEDNRRIYGKCNNPNGHGHNYKVEVTVKGKVDKDTGMVVNIADLKNIIKVSIMDTLDHKNLDKDVPFFKE--VVSTTENLSIFIWKQLSSNLPHGMLYRVKVHETDKNCVTFYGEF 144
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Match: A0A4Y2EJD3 (6-pyruvoyl tetrahydrobiopterin synthase OS=Araneus ventricosus OX=182803 GN=pts PE=3 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 3.631e-53
Identity = 83/139 (59.71%), Postives = 106/139 (76.26%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGEL 492
            PIVYLTR+E FSAAHRLH+PHL+  ENQ L+GKCN+PNGHGHNYK+EVT++  VD+ TG+  N+  LK  I+  +M LLDH+H+D DV YF++   VSTTENL+VFIW QL + L  G+L+ V +HETDKN   + GE 
Sbjct:    4 PIVYLTRVESFSAAHRLHSPHLNDEENQLLYGKCNNPNGHGHNYKVEVTVKGRVDQQTGMVMNITDLKEIIQKTIMELLDHKHLDKDVPYFKE--TVSTTENLSVFIWNQLSNSLPAGMLHCVKIHETDKNVVKFYGEF 140
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Match: A0A183LQN4 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS6109 PE=4 SV=1)

HSP 1 Score: 173.326 bits (438), Expect = 6.541e-52
Identity = 79/137 (57.66%), Postives = 104/137 (75.91%), Query Frame = 1 
Query:   79 IVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            + YLTR+E FSA HRLH+ HLS  EN +LF KCN+P GHGHNYKLEVT+  P+D+ TG+  N+  LK+ ++ NV+ LLDH++ID DV YF++  IVSTTENLAVFIW QL + + N +LY+V + ET+KN   Y+GE
Sbjct:    4 LCYLTRVESFSACHRLHSQHLSNEENVELFQKCNNPMGHGHNYKLEVTVSGPIDQRTGMIMNISDLKSVVQKNVLDLLDHKNIDEDVEYFKNNSIVSTTENLAVFIWSQLVNAIPNNLLYEVKIWETEKNIVTYRGE 140
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Match: V3ZN67 (6-pyruvoyl tetrahydrobiopterin synthase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_196888 PE=3 SV=1)

HSP 1 Score: 172.555 bits (436), Expect = 1.041e-51
Identity = 81/138 (58.70%), Postives = 105/138 (76.09%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            PIVY+TR E FSA HRLH+  LS +ENQ++FGKCN  NGHGHNY +EV ++ PVD  TG+  NL  LK  +K+ +M ++DH++IDLDV YF+D+  VST EN+A+FIW QL+ KL  G+LY++ LHETDKN   YKGE
Sbjct:    4 PIVYITRKESFSACHRLHSKTLSDAENQEIFGKCNHINGHGHNYTVEVVLKGPVDPVTGMVMNLVVLKQHMKECIMDVMDHKNIDLDVPYFKDK--VSTAENIAIFIWKQLEEKLSKGLLYEIKLHETDKNIVSYKGE 139
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Match: A0A183VJZ9 (6-pyruvoyl tetrahydrobiopterin synthase OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS333 PE=3 SV=1)

HSP 1 Score: 172.555 bits (436), Expect = 1.086e-51
Identity = 82/135 (60.74%), Postives = 101/135 (74.81%), Query Frame = 1 
Query:   85 YLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            YLTR+E FSA HRLH+ HL+  EN ++F KCN+P GHGHNYKLEVTIR P+D+ TG+  N+  LK  +K NV+ LLDH++ID DV YF+   IVSTTENLAVFIW QL   + N +LYKV + ET+KN   YKGE
Sbjct:    6 YLTRVESFSACHRLHSVHLNNEENVEIFQKCNNPMGHGHNYKLEVTIRGPIDQRTGMVINIADLKLILKKNVLDLLDHKNIDEDVEYFKRNNIVSTTENLAVFIWSQLADAIPNKLLYKVKVWETEKNIVTYKGE 140
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Cavefish
Match: pts (6-pyruvoyltetrahydropterin synthase [Source:NCBI gene;Acc:103046509])

HSP 1 Score: 154.836 bits (390), Expect = 4.541e-48
Identity = 69/135 (51.11%), Postives = 103/135 (76.30%), Query Frame = 1 
Query:   85 YLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            ++TR++ FSA HRLH+  L+  EN+++FGKCN+PNGHGHNYK+EVT+R  +D++TG+  NL  LK  I++ +M  LDH+++DLDV +F +  +VSTTENLAV+IW  +   L   +LY++ ++ETDKN  +Y+GE
Sbjct:   16 FITRVQSFSACHRLHSKSLTDEENKRIFGKCNNPNGHGHNYKVEVTVRGKIDRNTGMVMNLTDLKQYIEEAIMKPLDHKNLDLDVPHFAN--VVSTTENLAVYIWDNMVKLLPPNMLYEIKVYETDKNIVIYRGE 148
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Sea Lamprey
Match: pts (6-pyruvoyltetrahydropterin synthase [Source:ZFIN;Acc:ZDB-GENE-070615-3])

HSP 1 Score: 160.999 bits (406), Expect = 3.324e-51
Identity = 75/139 (53.96%), Postives = 103/139 (74.10%), Query Frame = 1 
Query:   73 GPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            G I  +TR+E FSA+HRLH+P LS  EN K+FGKCN+ NGHGHNYK+EVT+R  +D +TG+  N+  LK A++  +M  +DH+++D DV YF+D  + STTEN+AVF+W  L+  L  G L++V +HETDKN  VY+GE
Sbjct:   13 GRIARVTRLESFSASHRLHSPLLSDDENLKIFGKCNNQNGHGHNYKVEVTVRGKIDHATGMVMNIVDLKEAMQRAIMNPMDHKNLDKDVPYFKD--VPSTTENVAVFVWENLRKLLPEGSLFEVKIHETDKNVVVYRGE 149
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Nematostella
Match: EDO42759 (6-pyruvoyl tetrahydrobiopterin synthase [Source:UniProtKB/TrEMBL;Acc:A7S0L6])

HSP 1 Score: 156.377 bits (394), Expect = 3.815e-49
Identity = 76/139 (54.68%), Postives = 104/139 (74.82%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGEL 492
            P VY+TR E FSA HRLH+  L+  +N +LFGKCN+ NGHGHNYK+EVT+   VD+ TG+  NL +LK  I++ V++ LDH+++DLDV YF  Q +VST EN+AV+I+ QL   L +GILY+V +HETDKN   Y+G++
Sbjct:    7 PFVYITRSETFSACHRLHSTKLTDQQNIELFGKCNNKNGHGHNYKVEVTVASTVDEDTGMVMNLVALKGKIEE-VLSELDHKNLDLDVEYF--QTVVSTAENIAVYIYNQLNRGLPDGILYEVRVHETDKNVAFYRGQI 142
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Nematostella
Match: EDO39224 (6-pyruvoyl tetrahydrobiopterin synthase [Source:UniProtKB/TrEMBL;Acc:A7SAN5])

HSP 1 Score: 151.754 bits (382), Expect = 2.109e-47
Identity = 71/139 (51.08%), Postives = 105/139 (75.54%), Query Frame = 1 
Query:   76 PIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGEL 492
            P VY+TR E FSA+HRLHNP L+  +NQ+LFG+CN+ NGHGHNYK+ VT+   VD +TG+  NL +LK  I++ V+  LDH+++D+DV+YF+   +VST EN+A++I+ QL+  L +G LY+V L E++ +  VY+GE+
Sbjct:    7 PFVYITRTETFSASHRLHNPTLTNQKNQELFGRCNNKNGHGHNYKVSVTVASTVDGTTGMVINLVTLKGKIEE-VLGKLDHKNLDMDVAYFKT--VVSTAENVAIYIYDQLKPLLPDGSLYEVGLIESETDAAVYRGEM 142
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Medaka
Match: pts (6-pyruvoyltetrahydropterin synthase [Source:NCBI gene;Acc:101161840])

HSP 1 Score: 158.303 bits (399), Expect = 1.836e-49
Identity = 74/135 (54.81%), Postives = 99/135 (73.33%), Query Frame = 1 
Query:   85 YLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGE 489
            Y+TR++ FSA HRLH+ HLS  EN K++GKCN+PNGHGHNY +EVT+R  +D+ TG+  NL  LK  I++ +M  LDH+++D DV YF    +VSTTENLAV+IW  +   L  G LY++ +HETDKN  VY+GE
Sbjct:   15 YITRLQSFSACHRLHSVHLSDEENAKVYGKCNNPNGHGHNYTVEVTVRGKIDRVTGMVMNLTDLKRCIEEVIMIPLDHKNLDKDVPYF--ATVVSTTENLAVYIWDNMVKVLPPGQLYEIKIHETDKNIVVYRGE 147
[Close]
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Planmine SMEST
Match: SMESG000077201.1 (SMESG000077201.1)

HSP 1 Score: 301.212 bits (770), Expect = 4.605e-106
Identity = 144/144 (100.00%), Postives = 144/144 (100.00%), Query Frame = 1 
Query:   64 MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGELV 495
            MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGELV
Sbjct:    1 MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKLEVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGIVSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGELV 144
The following BLAST results are available for this feature:
BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PTS5.140e-4654.486-pyruvoyltetrahydropterin synthase [Source:HGNC S... [more]
PTS2.186e-2051.906-pyruvoyltetrahydropterin synthase [Source:HGNC S... [more]
PTS1.019e-1165.856-pyruvoyltetrahydropterin synthase [Source:HGNC S... [more]
PTS1.019e-1165.856-pyruvoyltetrahydropterin synthase [Source:HGNC S... [more]
PTS1.333e-1165.856-pyruvoyltetrahydropterin synthase [Source:HGNC S... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ptps-12.003e-4047.18Putative 6-pyruvoyl tetrahydrobiopterin synthase ... [more]
ptps-12.085e-4047.83Putative 6-pyruvoyl tetrahydrobiopterin synthase ... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pr2.090e-4550.00gene:FBgn0003141 transcript:FBtr0089395[more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pts4.639e-3946.726-pyruvoyltetrahydropterin synthase [Source:ZFIN;A... [more]
CABZ01058222.13.203e-825.36pep chromosome:GRCz11:12:292452:330202:1 gene:ENSD... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSXETT00000025579.17.488e-4851.096-pyruvoyltetrahydropterin synthase [Source:NCBI g... [more]
ENSXETT00000025583.11.712e-2348.246-pyruvoyltetrahydropterin synthase [Source:NCBI g... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Pts3.942e-4656.596-pyruvoyl-tetrahydropterin synthase [Source:MGI S... [more]
Pts1.150e-1953.166-pyruvoyl-tetrahydropterin synthase [Source:MGI S... [more]
Pts1.150e-1953.166-pyruvoyl-tetrahydropterin synthase [Source:MGI S... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P27213|PTPS_RAT4.162e-4758.146-pyruvoyl tetrahydrobiopterin synthase OS=Rattus ... [more]
sp|Q90W95|PTPS_POERE5.932e-4752.556-pyruvoyl tetrahydrobiopterin synthase OS=Poecili... [more]
sp|Q03393|PTPS_HUMAN2.468e-4554.486-pyruvoyl tetrahydrobiopterin synthase OS=Homo sa... [more]
sp|Q9R1Z7|PTPS_MOUSE2.757e-4556.596-pyruvoyl tetrahydrobiopterin synthase OS=Mus mus... [more]
sp|Q5REZ5|PTPS_PONAB4.443e-4554.486-pyruvoyl tetrahydrobiopterin synthase OS=Pongo a... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A087TID11.668e-5357.556-pyruvoyl tetrahydrobiopterin synthase (Fragment)... [more]
A0A4Y2EJD33.631e-5359.716-pyruvoyl tetrahydrobiopterin synthase OS=Araneus... [more]
A0A183LQN46.541e-5257.66Uncharacterized protein OS=Schistosoma margrebowie... [more]
V3ZN671.041e-5158.706-pyruvoyl tetrahydrobiopterin synthase OS=Lottia ... [more]
A0A183VJZ91.086e-5160.746-pyruvoyl tetrahydrobiopterin synthase OS=Trichob... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pts4.541e-4851.116-pyruvoyltetrahydropterin synthase [Source:NCBI g... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pts3.324e-5153.966-pyruvoyltetrahydropterin synthase [Source:ZFIN;A... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO427593.815e-4954.686-pyruvoyl tetrahydrobiopterin synthase [Source:U... [more]
EDO392242.109e-4751.086-pyruvoyl tetrahydrobiopterin synthase [Source:U... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pts1.836e-4954.816-pyruvoyltetrahydropterin synthase [Source:NCBI g... [more]
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BLAST of 6-pyruvoyl tetrahydrobiopterin synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000077201.14.605e-106100.00SMESG000077201.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015421 ID=SMED30015421|Name=6-pyruvoyl tetrahydrobiopterin synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=602bp
TAAAATCCACATTTTGCTTATCATATTAGCTAATATCAATTTTAATTTTA
ATTAAGTTTTTTGATGGCAACTGGGCCAATTGTCTATTTAACAAGAATTG
AGCAATTTTCAGCTGCTCATCGTCTACACAATCCTCACCTAAGCATTAGT
GAAAATCAAAAACTATTTGGTAAATGCAACAGTCCCAACGGGCATGGGCA
CAATTACAAATTAGAAGTAACTATTCGCCAACCGGTTGACAAAAGTACCG
GATTGTGCTACAATTTAGATTCTCTCAAAGCTGCAATTAAGGACAATGTA
ATGGCGTTGCTCGATCATCGGCATATTGATCTGGATGTCAGCTATTTTCG
TGATCAAGGAATTGTGTCGACCACTGAGAATTTAGCCGTTTTCATTTGGT
ATCAGCTGCAATCGAAGCTAGGAAATGGAATTCTTTACAAAGTTGTTCTC
CATGAAACTGACAAAAACAAATTTGTTTACAAAGGAGAATTAGTCTAATT
GTTTTCTAGTGATGAATTTTTGCTCTGCACTCACAATTGGTCTCACGAGT
TTCGATTTTGTATCTCTGATTTCGGTGCAATTGTAATTGATTAATAAAAC
AG
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protein sequence of SMED30015421-orf-1

>SMED30015421-orf-1 ID=SMED30015421-orf-1|Name=SMED30015421-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=145bp
MATGPIVYLTRIEQFSAAHRLHNPHLSISENQKLFGKCNSPNGHGHNYKL
EVTIRQPVDKSTGLCYNLDSLKAAIKDNVMALLDHRHIDLDVSYFRDQGI
VSTTENLAVFIWYQLQSKLGNGILYKVVLHETDKNKFVYKGELV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR0384186-PTP_synth/QueD_sf
IPR0071156-PTP_synth/QueD
Vocabulary: molecular function
TermDefinition
GO:00038746-pyruvoyltetrahydropterin synthase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006729tetrahydrobiopterin biosynthetic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR0384186-pyruvoyl tetrahydropterin synthase/QueD superfamilyGENE3DG3DSA:3.30.479.10coord: 1..142
e-value: 5.7E-53
score: 180.6
IPR0071156-pyruvoyl tetrahydropterin synthase/QueD familyPFAMPF01242PTPScoord: 9..141
e-value: 3.2E-29
score: 101.4
IPR0071156-pyruvoyl tetrahydropterin synthase/QueD familyPANTHERPTHR12589PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASEcoord: 7..142
NoneNo IPR availablePANTHERPTHR12589:SF76-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASEcoord: 7..142
NoneNo IPR availableSUPERFAMILYSSF55620Tetrahydrobiopterin biosynthesis enzymes-likecoord: 6..141