GLTP domain-containing protein

Overview
NameGLTP domain-containing protein
Smed IDSMED30015411
Length (bp)849
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of GLTP domain-containing protein (SMED30015411) t-SNE clustered cells

Violin plots show distribution of expression levels for GLTP domain-containing protein (SMED30015411) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GLTP domain-containing protein (SMED30015411) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GLTP domain-containing protein (SMED30015411) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015411

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 3 cellSMED30015411 dd_Smed_v6_2621_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30015411 dd_Smed_v4_2621_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Human
Match: GLTP (glycolipid transfer protein [Source:HGNC Symbol;Acc:HGNC:24867])

HSP 1 Score: 59.6918 bits (143), Expect = 4.106e-10
Identity = 40/155 (25.81%), Postives = 77/155 (49.68%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDF-TVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVK 650
            +  FF+  G+ +   +K D+ GN+ K+ +  D   N     ++  +L  EK+  G        T+ L+WLKR   F  V L +      + N+   + +   +AY+  LK +H   ++  F   +  AAPY+SDF++ ++    ++E+E L+ ++
Sbjct:   30 LPPFFDCLGSPVFTPIKADISGNITKIKAVYD--TNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAAL-YAAPYKSDFLKALSKGQNVTEEECLEKIR 181
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Human
Match: PLEKHA8 (pleckstrin homology domain containing A8 [Source:HGNC Symbol;Acc:HGNC:30037])

HSP 1 Score: 56.9954 bits (136), Expect = 1.205e-8
Identity = 48/168 (28.57%), Postives = 80/168 (47.62%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILD-DVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F   +  AAP   DF+  + +     ++E     ++  LS   P +     IL +  E   LES+
Sbjct:  357 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTEV--KNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALR-AAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESD 516
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Human
Match: PLEKHA8 (pleckstrin homology domain containing A8 [Source:HGNC Symbol;Acc:HGNC:30037])

HSP 1 Score: 56.9954 bits (136), Expect = 1.205e-8
Identity = 48/168 (28.57%), Postives = 80/168 (47.62%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILD-DVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F   +  AAP   DF+  + +     ++E     ++  LS   P +     IL +  E   LES+
Sbjct:  357 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTEV--KNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALR-AAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESD 516
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Human
Match: PLEKHA8 (pleckstrin homology domain containing A8 [Source:HGNC Symbol;Acc:HGNC:30037])

HSP 1 Score: 49.2914 bits (116), Expect = 4.569e-6
Identity = 33/104 (31.73%), Postives = 54/104 (51.92%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTF 548
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F
Sbjct:  357 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTEV--KNGEKDIQTALNNAYGKTLRQHHGWVVRGVF 453
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Human
Match: PLEKHA8 (pleckstrin homology domain containing A8 [Source:HGNC Symbol;Acc:HGNC:30037])

HSP 1 Score: 48.9062 bits (115), Expect = 5.160e-6
Identity = 33/104 (31.73%), Postives = 54/104 (51.92%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTF 548
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F
Sbjct:  357 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTEV--KNGEKDIQTALNNAYGKTLRQHHGWVVRGVF 453
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Celegans
Match: Y82E9BR.14 (pep chromosome:WBcel235:III:1409243:1414116:-1 gene:WBGene00022347.1 transcript:Y82E9BR.14a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y82E9BR.14)

HSP 1 Score: 76.6406 bits (187), Expect = 2.190e-16
Identity = 60/190 (31.58%), Postives = 87/190 (45.79%), Query Frame = 3 
Query:  195 ISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSI---CQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHIN----RNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVH---KILVSFQEEKDLES 734
            I+ F    GA+  +V+ D+ GN+ K+    +    G   +       +  H  K GI       T GLLWLKR   F + LL  + T  N    R+    ++  +  AY K+LK HH    K  F  V+T+A PYR   ++ +AL      QE LDDV  C+  +   L N     K LV +  EK L++
Sbjct:   53 IADFVSFLGATFSLVRKDIQGNVDKVRVRFEKDQEGQKYLQQLIDADLAEHGGKFGI------ATEGLLWLKRGLQFMLELLTEMVTAYNSGLPRDKTEDLSGAVATAYGKSLKRHHGFIAKQAFK-VVTMAVPYRRQILKAVALG-----QEGLDDV--CIHHIQCHLDNFRLNVKTLVDYYIEKKLDT 228
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Celegans
Match: Y82E9BR.14 (pep chromosome:WBcel235:III:1409311:1412865:-1 gene:WBGene00022347.1 transcript:Y82E9BR.14b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y82E9BR.14)

HSP 1 Score: 75.8702 bits (185), Expect = 1.028e-15
Identity = 62/196 (31.63%), Postives = 90/196 (45.92%), Query Frame = 3 
Query:  177 LQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSI---CQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHIN----RNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVH---KILVSFQEEKDLES 734
            +Q    IS+F    GA+  +V+ D+ GN+ K+    +    G   +       +  H  K GI       T GLLWLKR   F + LL  + T  N    R+    ++  +  AY K+LK HH    K  F  V+T+A PYR   ++ +AL      QE LDDV  C+  +   L N     K LV +  EK L++
Sbjct:  120 IQFSIQISNFSAFLGATFSLVRKDIQGNVDKVRVRFEKDQEGQKYLQQLIDADLAEHGGKFGI------ATEGLLWLKRGLQFMLELLTEMVTAYNSGLPRDKTEDLSGAVATAYGKSLKRHHGFIAKQAFK-VVTMAVPYRRQILKAVALG-----QEGLDDV--CIHHIQCHLDNFRLNVKTLVDYYIEKKLDT 301
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Match: gltpa (glycolipid transfer protein a [Source:NCBI gene;Acc:558007])

HSP 1 Score: 67.781 bits (164), Expect = 3.819e-13
Identity = 45/158 (28.48%), Postives = 82/158 (51.90%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDFTVALL-AFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCL 659
            +  FF+  G+++   +K D+ GN+ K+ +  D  +N     ++ Q+L  EK+  G        T+ L+WLKR   F   LL + +    + NN   + + + +AY+  LK +H   ++  F   +  AAPYRSDF++ ++    + ++E LD V+  L
Sbjct:   30 LPPFFDCLGSAVFSPIKADIAGNITKIKAVYD--SNPTRFKTLQQILEAEKEMHGAEWPKVGATLALMWLKRGLRFIQVLLQSLVDGDKDDNNPNLIKVNVTKAYEMALKKYHGWIVQKLFQAAL-YAAPYRSDFLRALSKGREVKDEECLDKVRQFL 184
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Match: gltpb (glycolipid transfer protein b [Source:ZFIN;Acc:ZDB-GENE-091118-80])

HSP 1 Score: 66.2402 bits (160), Expect = 1.633e-12
Identity = 46/180 (25.56%), Postives = 90/180 (50.00%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKR-GINKKDPSGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKD 725
            +  FF+  G+ +   +K+D++GN+ K+ +  D  ++     ++ Q+L  EK   G        T+ L+WLKR   F   LL  L     + +N   + + + +AYD+ LK +H   ++  F   +  AAP RSDF++ ++ D  ++E++ L  V+  L      +  ++++  +   E D
Sbjct:   30 LPPFFDCLGSKVFAPIKSDINGNITKIKAVYD--SDPVKYETLQQILIIEKSSYGSEWPKVGATLALMWLKRGLRFIQILLQSLADGERDEDNPNLIRVNITKAYDQALKRYHGWIVQKVFKAAL-FAAPCRSDFLKALSKDQEVAEEDCLAKVRQFLINFTATVDAIYEMYSTMNAELD 206
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Match: CR925820.18 (glycolipid transfer protein b [Source:NCBI gene;Acc:568746])

HSP 1 Score: 65.0846 bits (157), Expect = 3.554e-12
Identity = 46/180 (25.56%), Postives = 90/180 (50.00%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKR-GINKKDPSGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKD 725
            +  FF+  G+ +   +K+D++GN+ K+ +  D  ++     ++ Q+L  EK   G        T+ L+WLKR   F   LL  L     + +N   + + + +AYD+ LK +H   ++  F   +  AAP RSDF++ ++ D  ++E++ L  V+  L      +  ++++  +   E D
Sbjct:   30 LPPFFDCLGSKVFAPIKSDINGNITKIKAVYD--SDPVKYETLQQILIIEKSSYGSEWPKVGATLALMWLKRGLRFIQILLQSLADGERDEDNPNLIRVNITKAYDQALKRYHGWIVQKVFKAAL-FAAPCRSDFLKALSKDQEVAEEDCLAKVRLFLINFTATVDAIYEMYSTMNAELD 206
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Match: gltpb (glycolipid transfer protein b [Source:ZFIN;Acc:ZDB-GENE-091118-80])

HSP 1 Score: 55.8398 bits (133), Expect = 2.794e-9
Identity = 37/136 (27.21%), Postives = 66/136 (48.53%), Query Frame = 3 
Query:  324 QMLTHEKKR-GINKKDPSGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKD 725
            Q+L  EK   G        T+ L+WLKR   F   LL  L     + +N   + + + +AYD+ LK +H   ++  F   +  AAP RSDF++ ++ D  ++E++ L  V+  L      +  ++++  +   E D
Sbjct:   20 QILIIEKSSYGSEWPKVGATLALMWLKRGLRFIQILLQSLADGERDEDNPNLIRVNITKAYDQALKRYHGWIVQKVFKAAL-FAAPCRSDFLKALSKDQEVAEEDCLAKVRQFLINFTATVDAIYEMYSTMNAELD 154
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Match: plekha8 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Source:NCBI gene;Acc:492502])

HSP 1 Score: 48.9062 bits (115), Expect = 3.331e-6
Identity = 43/167 (25.75%), Postives = 74/167 (44.31%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D  GN++K+   + ++++ +S  ++  ++ HE K  + +   S T  LLWLKR   F    L  + T +        ALY   AY KTL+ +H   ++  F   +  A  Y       ++ +    ++     +   L    P + N   IL +  EE  LES+
Sbjct:  387 VKIDFVGNIKKIQ--QKVVSDPESFPTLQSIVLHEVKTEVAQVRNSATEALLWLKRGLKFLKEFLYEINTGV---KDVQGALY--NAYGKTLRQYHGWVVRGVFALALRAAPSYEGFMAALVSYEGDELKEGFRTGMHRDLDIYLPAMENQLSILDTLYEEYGLESD 546
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Xenopus
Match: gltp (glycolipid transfer protein [Source:NCBI gene;Acc:548793])

HSP 1 Score: 67.0106 bits (162), Expect = 1.110e-12
Identity = 42/159 (26.42%), Postives = 82/159 (51.57%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDP--SGTIGLLWLKRTFDF-TVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCL 659
            + +FF+  G+++   +K D+ GN+ K+ S   +  +  S     QM+   +K     + P    T+ L+WLKR   F  V L +      +  N   + + + +AY+  LK +H  F++  F T + +AAPY+ DF++ ++   T+ E+E ++ ++  L
Sbjct:   30 LPAFFDCLGSAIFSPIKADITGNISKIRS---VYESNPSKFKTLQMILEGEKELHGPQWPKVGATLALMWLKRGLKFIQVMLQSIADGERDDQNPNLIKVNITKAYEIALKKYHGWFVQKIFQTAL-IAAPYKDDFLKALSKGQTVKEEECIEKIRQFL 184
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Xenopus
Match: PLEKHA8 (pleckstrin homology domain containing A8 [Source:NCBI gene;Acc:100489403])

HSP 1 Score: 54.299 bits (129), Expect = 9.564e-8
Identity = 44/168 (26.19%), Postives = 77/168 (45.83%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQE-ILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D  GN++K++  +  I + +   ++ +++ HE    + +   S T  LLWLKR   F    L  +     RN +  +   L  AY KTL+ +H   ++  F   +  AAP    F   ++++     +E   + +K  L+   P +     IL +  EE  LES+
Sbjct:  385 VKMDFVGNIKKIN--QKYITSKEEFTTLQKIVLHEVNANVTQVRNSATEALLWLKRGLKFLYEFLCEV-----RNGEKNIQTALSNAYGKTLRQYHGWVVRGVFALALR-AAPTYEGFATALSIEEGEGNKEGFFNAMKRDLNIYLPAMQKQLNILDTLYEEHGLESD 544
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Mouse
Match: Gltp (glycolipid transfer protein [Source:MGI Symbol;Acc:MGI:1929253])

HSP 1 Score: 58.5362 bits (140), Expect = 7.864e-10
Identity = 43/180 (23.89%), Postives = 83/180 (46.11%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDF-TVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKD 725
            +  FF+  G+ +   +K D+ GN+ K+ +  D   +     ++  +L  EK   G        T+ LLWLKR   F  V L +      + N+   + +   +AY+  LK +H   ++  F   +  AAPY+SDF++ ++    ++E+E L+ ++  L      +  ++ +      E D
Sbjct:   30 LPPFFDCLGSPVFTPIKADISGNITKIKAVYD--TDPAKFKTLQNILEVEKGMYGAEWPKVGATLALLWLKRGLRFIQVFLQSICDGERDENHPNLIRVNANKAYEMALKKYHGWLVQKIFKAAL-YAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDAIYDMYTKMNAELD 206
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Mouse
Match: Plekha8 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Source:MGI Symbol;Acc:MGI:2681164])

HSP 1 Score: 56.9954 bits (136), Expect = 8.740e-9
Identity = 48/168 (28.57%), Postives = 80/168 (47.62%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILD-DVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F   +  AAP   DF+  + +     ++E     ++  LS   P +     IL +  E   LES+
Sbjct:  357 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTE--VKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALR-AAPSYEDFVAALTIKEGDHQKEAFSAGMQRDLSLYLPAMEKQLAILDTLYEIHGLESD 516
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Mouse
Match: Plekha8 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Source:MGI Symbol;Acc:MGI:2681164])

HSP 1 Score: 56.6102 bits (135), Expect = 1.158e-8
Identity = 48/168 (28.57%), Postives = 80/168 (47.62%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILD-DVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D+ GN++K++  +  I N +   ++ +++ HE +  + +   S T  LLWLKR   F   L  FLT    +N +  +   L  AY KTL+ HH   ++  F   +  AAP   DF+  + +     ++E     ++  LS   P +     IL +  E   LES+
Sbjct:  312 VKMDLVGNIKKVN--QKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKF---LKGFLTE--VKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALR-AAPSYEDFVAALTIKEGDHQKEAFSAGMQRDLSLYLPAMEKQLAILDTLYEIHGLESD 471
[Close]
BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Match: sp|O22797|GLTP1_ARATH (Glycolipid transfer protein 1 OS=Arabidopsis thaliana OX=3702 GN=GLTP1 PE=2 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 6.077e-15
Identity = 56/187 (29.95%), Postives = 86/187 (45.99%), Query Frame = 3 
Query:  147 DGPDYLIDDILQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVS 707
            D  + L    L++ K I    + FGA+M +VK+D+ GN+ +L   K+ +++ D    +   +  E +  I K   S T GLLWL R  DF V L   L  H       +M      +Y KTLK  H     +TF+  + + AP R  F+  I+         I  D++   ++  P L + HK L S
Sbjct:   19 DQGEMLTKPFLELCKTILPVIDKFGAAMTLVKSDIGGNITRL--EKNYLSDPDKFKYLYTFVQVEIESKIAKGSSSCTNGLLWLTRAMDFLVELFRNLVAH----QDWSMPQACADSYQKTLKKWHGWLASSTFSMALKL-APDRKKFMDVIS-----GSGNIQADMERFCAEFGPFLHDNHKFLAS 193
[Close]
BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Match: sp|B0BLT4|GLTP_XENTR (Glycolipid transfer protein OS=Xenopus tropicalis OX=8364 GN=gltp PE=2 SV=1)

HSP 1 Score: 69.3218 bits (168), Expect = 8.340e-13
Identity = 43/159 (27.04%), Postives = 83/159 (52.20%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDP--SGTIGLLWLKRTFDF-TVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCL 659
            + +FF+ FG+++   +K D+ GN+ K+ S   +  +  S     QM+   +K     + P    T+ L+WLKR   F  V L +      +  N   + + + +AY+  LK +H  F++  F T + +AAPY+ DF++ ++   T+ E+E ++ ++  L
Sbjct:   30 LPAFFDCFGSAIFSPIKADITGNISKIRS---VYESNPSKFKTLQMILEGEKELHGPQWPKVGATLALMWLKRGLKFIQVMLQSIADGERDDQNPNLIKVNITKAYEIALKKYHGWFVQKIFQTAL-IAAPYKDDFLKALSKGQTVKEEECIEKIRQFL 184
[Close]
BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Match: sp|A2BG43|GLTP_DANRE (Glycolipid transfer protein OS=Danio rerio OX=7955 GN=gltp PE=3 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 2.883e-12
Identity = 45/158 (28.48%), Postives = 82/158 (51.90%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDFTVALL-AFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCL 659
            +  FF+  G+++   +K D+ GN+ K+ +  D  +N     ++ Q+L  EK+  G        T+ L+WLKR   F   LL + +    + NN   + + + +AY+  LK +H   ++  F   +  AAPYRSDF++ ++    + ++E LD V+  L
Sbjct:   30 LPPFFDCLGSAVFSPIKADIAGNITKIKAVYD--SNPTRFKTLQQILEAEKEMHGAEWPKVGATLALMWLKRGLRFIQVLLQSLVDGDKDDNNPNLIKVNVTKAYEMALKKYHGWIVQKLFQAAL-YAAPYRSDFLRALSKGREVKDEECLDKVRQFL 184
[Close]
BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NLQ3|GLTP2_ARATH (Glycolipid transfer protein 2 OS=Arabidopsis thaliana OX=3702 GN=GLTP2 PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.918e-12
Identity = 48/181 (26.52%), Postives = 84/181 (46.41%), Query Frame = 3 
Query:  174 ILQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAV--SICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSF 710
            IL    +I    +  G +M +++ D+D N+++L          DS V  ++ ++L  EK+ G +K   S    L WL RT DFT  LL  L+  ++    + M   +++ Y  TLK HH       F   + +  P    F++ I   +  S   + +D+ +  S L PIL  ++ +L  +
Sbjct:   45 ILSFCSLIIQVLDKIGPTMAVLRQDIDQNIQRLEK----FYETDSCVYSNLAEILKKEKEEGTSKMVASCGRALFWLTRTMDFTAGLLRLLSKEMS----SKMEELVEECYMTTLKPHHGWIASAAFKVCLKL-VPDNKTFMEAIGARDE-SYDTLREDIDTLSSLLTPILKEIYFVLEQY 215
[Close]
BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NU44|GLTPB_XENLA (Glycolipid transfer protein B OS=Xenopus laevis OX=8355 GN=gltp-b PE=2 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 2.990e-11
Identity = 41/159 (25.79%), Postives = 81/159 (50.94%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDP--SGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCL 659
            + +FF+  G+++   +K D+ GN+ K+ S   +  +  +     QM+   +K     K P    T+ L+WLKR   F   LL  ++    +  N   + + + +AYD  LK +H   ++  F T + +AAPY+ DF++ ++    + E+E ++ ++  L
Sbjct:   30 LPAFFDCLGSAIFSPIKADITGNITKIRS---VYESNPTQFKTLQMILEGEKELYGPKWPKAGATLALMWLKRGLKFIQVLLQSISDGERDDQNPNLIKVNITKAYDIALKNYHGWLVQKFFQTAL-IAAPYKDDFLKALSKGQAVKEEECIEKIRKFL 184
[Close]
BLAST of GLTP domain-containing protein vs. TrEMBL
Match: A0A4E0S139 (Glycolipid transfer protein OS=Fasciola hepatica OX=6192 GN=D915_005018 PE=4 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 4.621e-33
Identity = 66/179 (36.87%), Postives = 117/179 (65.36%), Query Frame = 3 
Query:  192 VISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDL 728
            ++S FF L+G+ M +VK+DV+GN++K+S++        +  ++ +ML  E+   + KKD SG++GLLWLKR+F F V++L FL+   N +   T+   + QAYD++L+ +H+  M+ TF+ V+  A P RS F++K+ALD    E+++L D   C S L P ++ + ++L++++ E+ L
Sbjct:   34 LLSDFFTLWGSRMALVKSDVEGNIQKVSNA----VCSLNCTTLPEMLAKERSLDLYKKDSSGSVGLLWLKRSFQFLVSVLWFLSKSTNEDCMKTI---VSQAYDESLRHYHSRLMRHTFHFVMH-ALPKRSSFVKKLALDQEGCEEQVLVDALECRSLLLPFVARLEELLIAYKLEQPL 204
[Close]
BLAST of GLTP domain-containing protein vs. TrEMBL
Match: A0A504YPU6 (Glycolipid transfer protein OS=Fasciola gigantica OX=46835 GN=FGIG_04565 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 7.551e-33
Identity = 66/179 (36.87%), Postives = 116/179 (64.80%), Query Frame = 3 
Query:  192 VISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDL 728
            ++S FF L+G+ M +VK+DV+GN++K+S++        +  ++ +ML  E+   + KKD SG++GLLWLKR+F F V++L FL+   N +   T+   + QAYD++L+ +H+  M+ TF  V+  A P RS F++K+ALD    E+++L D   C S L P ++ + ++L++++ E+ L
Sbjct:   34 LLSDFFTLWGSRMALVKSDVEGNIQKVSNA----VCSLNCTTLPEMLAKERSLDLYKKDSSGSVGLLWLKRSFQFLVSVLWFLSKSTNEDCMKTI---VSQAYDESLRHYHSRLMRHTFRFVMH-ALPKRSSFVKKLALDQEGCEEQVLVDALKCRSLLLPFVARLEELLIAYKLEQPL 204
[Close]
BLAST of GLTP domain-containing protein vs. TrEMBL
Match: A0A5J4NRU1 (GLTP domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0010640 PE=4 SV=1)

HSP 1 Score: 127.487 bits (319), Expect = 4.167e-32
Identity = 71/205 (34.63%), Postives = 121/205 (59.02%), Query Frame = 3 
Query:  105 KKTIFSTIEIPKTLDGPDYLIDDILQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEE 719
            + T FS+++  +  D  DY     +   +++  F  L+G+   +VK+DVDGN++K+S++        +  S+  ML  E++  I KKD SG++GLLWLKRT+DF +  L +L+      +  +M   + QAYD+TL+ +HN FM+ TF  V+  + P R+ FI+K+ALD    EQ +L     C+  + P++  ++++L+ FQ E
Sbjct:    9 RPTFFSSVQ--ELGDFTDYNFQTFIACSQILLDFLTLWGSRFYIVKSDVDGNIKKVSNA----VKSLNVTSLKDMLALEQQLNICKKDSSGSVGLLWLKRTYDFLLKTLWYLS---QSGSDESMRNIILQAYDQTLRKYHNKFMRQTFKVVL-FSLPKRAAFIKKLALDQDDCEQLVLKGATDCVHMVKPLVHQLNQLLIEFQLE 203
[Close]
BLAST of GLTP domain-containing protein vs. TrEMBL
Match: A0A267EH70 (GLTP domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011947g2 PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 4.860e-28
Identity = 66/229 (28.82%), Postives = 121/229 (52.84%), Query Frame = 3 
Query:  102 SKKTIFSTIEIPK----TLDGPDYLIDDILQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAV-------SICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIAL-DNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESNIYMIS 752
            +K+T F++I+         DG D  +  +  +G+ +S FF+  G S +  +NDV GN+RK++ +   + +  +A        S+  +L  E+  G+  KDPSGTIGLLW KR  ++  ALL  + +   R     MA   ++AY+ TLK  H+  ++ TF  VI+  +P RS F+ ++   D++++E E+ + + + L  +  +L  ++  L  +  E     ++  +S
Sbjct:   21 TKRTFFTSIDWAALSSAGSDGCDIRVAGLCALGEAVSEFFDQLGVSFKPARNDVAGNVRKMTDAAKQLDSAPAAGAEEFQTGSVGHLLQSEQASGLAAKDPSGTIGLLWFKRALEYLYALLCLVHSSRARTGDFGMAELCRRAYEATLKPRHSWLVQKTFGLVIST-SPKRSQFLARVTYGDDSVNEDELYESMAASLVAMRRLLECLNAALCRYNVESPPVPDLAALS 248
[Close]
BLAST of GLTP domain-containing protein vs. TrEMBL
Match: A0A267E590 (GLTP domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004190g1 PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 5.016e-28
Identity = 65/229 (28.38%), Postives = 121/229 (52.84%), Query Frame = 3 
Query:  102 SKKTIFSTIEIPK----TLDGPDYLIDDILQIGKVISSFFELFGASMRMVKNDVDGNLRKLSSSKDLIANGDSAV-------SICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIAL-DNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESNIYMIS 752
            +K+T F++I+         DG D  +  +  +G+ +S FF+  G S +  +NDV GN+RK++ +   + +  +A        S+  +L  E+  G+  KDPSGTIGLLW KR  ++  A+L  + +   R     MA   ++AY+ TLK  H+  ++ TF  VI+  +P RS F+ ++   D++++E E+ + + + L  +  +L  ++  L  +  E     ++  +S
Sbjct:   21 TKRTFFTSIDWAALSSAGSDGCDIRVAGLCALGEAVSEFFDQLGVSFKPARNDVAGNVRKMTDAAKQLDSAPAAGAEEFQTGSVGHLLQSEQASGLGAKDPSGTIGLLWFKRALEYLYAMLCLVHSSRARTGDFGMAELCRRAYEATLKPRHSWLVQKTFGLVIST-SPKRSQFLARVTYGDDSVNEDELYESMAASLVAMRRLLECLNAALCRYNVESPPVPDLAALS 248
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Cavefish
Match: gltpa (glycolipid transfer protein a [Source:NCBI gene;Acc:558007])

HSP 1 Score: 71.2478 bits (173), Expect = 1.675e-14
Identity = 47/188 (25.00%), Postives = 94/188 (50.00%), Query Frame = 3 
Query:  177 LQIGKVISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLES 734
            L+    +  FF+  G+++   VK D+ GN+ K+ +  D   N     ++ Q+L  EK+  G        T+ L+WLKR+  ++V L + +    + NN   + + + +AY+  LK +H   ++  F T    AAPY+SDF++ ++    + E++ L+ V+  L      +  ++++      E D ++
Sbjct:   24 LEAVSYLPPFFDCLGSTVFAPVKADIAGNITKIKAVYD--TNPGRFKTLQQILEAEKEMHGAEWPKVGATLSLMWLKRSAVYSVLLQSLVDGEKDENNPNLIRVNVTKAYEIALKKYHGWLVQKLF-TAALYAAPYKSDFLKALSKGREVKEEDCLEKVRQFLVNYTATIDAIYEMFTKMNAELDYKA 208
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000038553.1 (glycolipid transfer protein-like [Source:NCBI gene;Acc:111195006])

HSP 1 Score: 58.5362 bits (140), Expect = 5.716e-10
Identity = 38/140 (27.14%), Postives = 74/140 (52.86%), Query Frame = 3 
Query:  195 ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIA 605
            +  FF+  G+ +   +K D+ GN+ K+ +  D  ++ +   ++ ++L  EK+  G        T+ L+WLKR   F   LL  L     + NN   + + + +AY++ LK +H   ++  F   + +AAPYRS+F++ ++
Sbjct:   30 LPPFFDCLGSKVFAPIKADISGNITKIKAVYD--SDPEKYETLQKILEAEKEIYGSEWPKAGATLALMWLKRGLRFIQILLQSLADGERDENNPNLIRVNITKAYEQALKRYHGWIVQKVFKAAL-LAAPYRSNFLKALS 166
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Nematostella
Match: EDO41182 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S549])

HSP 1 Score: 62.3882 bits (150), Expect = 8.707e-12
Identity = 51/160 (31.87%), Postives = 86/160 (53.75%), Query Frame = 3 
Query:  186 GKVISSFFELFGA-SMRMVKNDVDGNLRKLSSSKDLIANGDSAV--SICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQ-EILDDVKS 653
            G+V+  FF+L G+ +   VK D++GN+ KL      I   D A   ++  ++  E +    K   SGT  LLWL+R   F   ++AFL   +  N++  +A    +AY+KTLK +H   ++  F+  +  A PYR DF++  AL     EQ  +++D+++
Sbjct:   30 GEVVP-FFDLLGSTAFAPVKMDINGNITKLRK----IYETDPARFKTLQDVVEKEIENKTTKAKNSGTDALLWLRRALHF---IIAFLKEVLVGNSE--LAPCATKAYEKTLKKYHGFLVRGVFSLAMK-AVPYRKDFMK--ALGGAEEEQYTVMEDIQN 176
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Nematostella
Match: EDO37291 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG84])

HSP 1 Score: 47.7506 bits (112), Expect = 2.769e-6
Identity = 35/120 (29.17%), Postives = 58/120 (48.33%), Query Frame = 3 
Query:  192 VISSFFELFGA-SMRMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTF 548
             I  FF++ G+ +   VK D+ GN+RK+SS  D   +  +  ++  ++  E K        S T  LLWLKR  +F    LA +        +  +A+    AY+KTL+ +H   ++  F
Sbjct:  355 CILPFFDVMGSTAFAPVKMDIGGNIRKISSKFD--TDPKAFYTLQNIVYQELKSNTCTAKNSATDALLWLKRALEFMQIFLAEVV-----KGRQDLAVAAGIAYEKTLRKYHGWVVRGVF 467
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Medaka
Match: gltpb (glycolipid transfer protein [Source:NCBI gene;Acc:101164488])

HSP 1 Score: 72.0182 bits (175), Expect = 1.124e-14
Identity = 48/196 (24.49%), Postives = 102/196 (52.04%), Query Frame = 3 
Query:  153 PDYLIDDILQIGKV--ISSFFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDFTVALLAFLT-THINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKD 725
            PD  ID  + +  V  I +FF+  G+ +  ++K+D+ GN+ K+ +    + +     ++  +L  E++  G    +   T+ L+WLKR   F   LL  L     + NN   + + + +AY+ +LK +H   ++  FN  + +AAPYRS+F++ ++    ++E++   +V+  L   + ++  ++++  +   E D
Sbjct:   14 PDKSIDTKIFLENVSNIPTFFDCLGSKVFTVIKSDITGNITKIRAV--YVKDPAKYATLQDILVAEREAHGAEWPNVGATLALMWLKRGLRFIQVLLQSLADGERDENNPNLIRVNVTKAYESSLKRYHGWIVQKIFNAAL-LAAPYRSNFLKALSKGEEVTEEDCFANVRQFLVNYSCVVDAIYEMYTNLNAELD 206
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Medaka
Match: gltpa (glycolipid transfer protein [Source:NCBI gene;Acc:101169614])

HSP 1 Score: 65.4698 bits (158), Expect = 2.142e-12
Identity = 44/168 (26.19%), Postives = 86/168 (51.19%), Query Frame = 3 
Query:  204 FFELFGASM-RMVKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKK-RGINKKDPSGTIGLLWLKRTFDF-TVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKI 698
            FF+  G+++   +K D+ GN+ K+ +  D   N     ++ Q+L  EK+  G        T+ L+WLKR+  F  + L + +    +++N   + + L + YD  LK +H   ++  F   +  AAPY+SDF++ ++    + E+E L+ ++  L   +  +  V+ I
Sbjct:   33 FFDCLGSTIFAPIKVDLIGNIAKIKAVYD--TNPGRYKTLQQLLEAEKEMYGSEWPRVGATLALMWLKRSLKFIQIFLQSLVNGEKDQSNPNLLRVNLTKGYDTALKRYHGWLVQQLFKAAL-YAAPYKSDFLKALSKGRDVKEEECLEKIRKFLVNFSANIDAVYDI 197
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Medaka
Match: plekha8 (pleckstrin homology domain containing A8 [Source:NCBI gene;Acc:101159609])

HSP 1 Score: 47.7506 bits (112), Expect = 7.016e-6
Identity = 42/167 (25.15%), Postives = 73/167 (43.71%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D  GN++K+   + L+++ +   ++  ++ HE +  + +   S T  LLWL+R   F   L  FL + +N   +      L  AY KTL+ +H   ++  F   +  A  Y S     +  +      E  + +   L    P +     IL    EE +LES+
Sbjct:  339 VKMDFVGNIKKIH--QKLMSDPECFPTLQSIVQHEVRTEVAQVRNSATEALLWLRRGLKF---LKEFL-SEVNAGERDIQGA-LNNAYGKTLRIYHGWVVRGVFALALRAAPCYESFTAALVTREGDELHSEFTNSMHRDLGMYLPAMEKQLAILDELYEEYNLESD 498
[Close]
BLAST of GLTP domain-containing protein vs. Ensembl Medaka
Match: plekha8 (pleckstrin homology domain containing A8 [Source:NCBI gene;Acc:101159609])

HSP 1 Score: 47.3654 bits (111), Expect = 9.746e-6
Identity = 42/167 (25.15%), Postives = 73/167 (43.71%), Query Frame = 3 
Query:  237 VKNDVDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWLKRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTFNTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKILVSFQEEKDLESN 737
            VK D  GN++K+   + L+++ +   ++  ++ HE +  + +   S T  LLWL+R   F   L  FL + +N   +      L  AY KTL+ +H   ++  F   +  A  Y S     +  +      E  + +   L    P +     IL    EE +LES+
Sbjct:  395 VKMDFVGNIKKIH--QKLMSDPECFPTLQSIVQHEVRTEVAQVRNSATEALLWLRRGLKF---LKEFL-SEVNAGERDIQGA-LNNAYGKTLRIYHGWVVRGVFALALRAAPCYESFTAALVTREGDELHSEFTNSMHRDLGMYLPAMEKQLAILDELYEEYNLESD 554
The following BLAST results are available for this feature:
BLAST of GLTP domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GLTP4.106e-1025.81glycolipid transfer protein [Source:HGNC Symbol;Ac... [more]
PLEKHA81.205e-828.57pleckstrin homology domain containing A8 [Source:H... [more]
PLEKHA81.205e-828.57pleckstrin homology domain containing A8 [Source:H... [more]
PLEKHA84.569e-631.73pleckstrin homology domain containing A8 [Source:H... [more]
PLEKHA85.160e-631.73pleckstrin homology domain containing A8 [Source:H... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Y82E9BR.142.190e-1631.58pep chromosome:WBcel235:III:1409243:1414116:-1 gen... [more]
Y82E9BR.141.028e-1531.63pep chromosome:WBcel235:III:1409311:1412865:-1 gen... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GLTP domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gltpa3.819e-1328.48glycolipid transfer protein a [Source:NCBI gene;Ac... [more]
gltpb1.633e-1225.56glycolipid transfer protein b [Source:ZFIN;Acc:ZDB... [more]
CR925820.183.554e-1225.56glycolipid transfer protein b [Source:NCBI gene;Ac... [more]
gltpb2.794e-927.21glycolipid transfer protein b [Source:ZFIN;Acc:ZDB... [more]
plekha83.331e-625.75pleckstrin homology domain containing, family A (p... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gltp1.110e-1226.42glycolipid transfer protein [Source:NCBI gene;Acc:... [more]
PLEKHA89.564e-826.19pleckstrin homology domain containing A8 [Source:N... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Gltp7.864e-1023.89glycolipid transfer protein [Source:MGI Symbol;Acc... [more]
Plekha88.740e-928.57pleckstrin homology domain containing, family A (p... [more]
Plekha81.158e-828.57pleckstrin homology domain containing, family A (p... [more]
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BLAST of GLTP domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O22797|GLTP1_ARATH6.077e-1529.95Glycolipid transfer protein 1 OS=Arabidopsis thali... [more]
sp|B0BLT4|GLTP_XENTR8.340e-1327.04Glycolipid transfer protein OS=Xenopus tropicalis ... [more]
sp|A2BG43|GLTP_DANRE2.883e-1228.48Glycolipid transfer protein OS=Danio rerio OX=7955... [more]
sp|Q6NLQ3|GLTP2_ARATH7.918e-1226.52Glycolipid transfer protein 2 OS=Arabidopsis thali... [more]
sp|Q6NU44|GLTPB_XENLA2.990e-1125.79Glycolipid transfer protein B OS=Xenopus laevis OX... [more]
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BLAST of GLTP domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0S1394.621e-3336.87Glycolipid transfer protein OS=Fasciola hepatica O... [more]
A0A504YPU67.551e-3336.87Glycolipid transfer protein OS=Fasciola gigantica ... [more]
A0A5J4NRU14.167e-3234.63GLTP domain-containing protein OS=Paragonimus west... [more]
A0A267EH704.860e-2828.82GLTP domain-containing protein (Fragment) OS=Macro... [more]
A0A267E5905.016e-2828.38GLTP domain-containing protein (Fragment) OS=Macro... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gltpa1.675e-1425.00glycolipid transfer protein a [Source:NCBI gene;Ac... [more]
ENSAMXT00000038553.15.716e-1027.14glycolipid transfer protein-like [Source:NCBI gene... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GLTP domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GLTP domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO411828.707e-1231.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO372912.769e-629.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of GLTP domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
gltpb1.124e-1424.49glycolipid transfer protein [Source:NCBI gene;Acc:... [more]
gltpa2.142e-1226.19glycolipid transfer protein [Source:NCBI gene;Acc:... [more]
plekha87.016e-625.15pleckstrin homology domain containing A8 [Source:N... [more]
plekha89.746e-625.15pleckstrin homology domain containing A8 [Source:N... [more]
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BLAST of GLTP domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 0
Match NameE-valueIdentityDescription
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015411 ID=SMED30015411|Name=GLTP domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=849bp
AATTTTACGATATATATTAATAATTAATTTTGTGTTTTATTTATTAAACA
CTTATTAATAAAATAGATACTTGTTTTAAGTTGCAAGGTCATATTAATAT
GAGTAAAAAAACCATATTTAGTACAATAGAGATTCCTAAAACCTTGGACG
GTCCAGATTATCTCATAGATGATATTCTACAAATTGGCAAAGTTATTTCA
AGTTTTTTTGAATTATTTGGAGCATCAATGCGAATGGTAAAGAATGATGT
TGATGGAAATTTAAGGAAGTTGTCTTCCAGTAAAGACTTGATAGCAAACG
GGGACTCGGCTGTCTCAATCTGTCAAATGTTGACACACGAAAAAAAACGC
GGTATAAATAAGAAAGATCCATCAGGAACGATTGGACTGCTATGGTTGAA
AAGGACCTTTGATTTCACAGTTGCTTTGCTGGCATTCCTAACTACTCATA
TCAATCGAAACAATCAGGCTACGATGGCTTTATATTTAAAGCAAGCTTAC
GACAAAACACTAAAATTCCATCACAACGTTTTCATGAAAACGACATTCAA
TACGGTGATAACCGTTGCCGCGCCTTACAGAAGTGACTTCATACAAAAAA
TAGCTTTAGATAATACTCTCAGTGAACAAGAAATCCTCGACGATGTGAAA
TCTTGTTTGAGCCAGTTAGCGCCAATATTGTCAAATGTCCATAAAATCCT
TGTCAGTTTCCAGGAGGAAAAGGATCTGGAATCAAATATTTATATGATAT
CTTAATCTCAGTGAATTCGTTTTATTTTACTTTAGTATGAATATTTTGCT
TTTGAATTTCAAAAATTTATCGATGGTGAAAAAAAAAATTCTTGAAAAA
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protein sequence of SMED30015411-orf-1

>SMED30015411-orf-1 ID=SMED30015411-orf-1|Name=SMED30015411-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=219bp
MSKKTIFSTIEIPKTLDGPDYLIDDILQIGKVISSFFELFGASMRMVKND
VDGNLRKLSSSKDLIANGDSAVSICQMLTHEKKRGINKKDPSGTIGLLWL
KRTFDFTVALLAFLTTHINRNNQATMALYLKQAYDKTLKFHHNVFMKTTF
NTVITVAAPYRSDFIQKIALDNTLSEQEILDDVKSCLSQLAPILSNVHKI
LVSFQEEKDLESNIYMIS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0120009intermembrane lipid transfer
GO:0046836glycolipid transport
Vocabulary: molecular function
TermDefinition
GO:0120013intermembrane lipid transfer activity
GO:0051861glycolipid binding
GO:0017089glycolipid transporter activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000034epidermis
PLANA:0000035Category 3 cell
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036497GLTP_sf
IPR014830Glycolipid_transfer_prot_dom
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014830Glycolipid transfer protein domainPFAMPF08718GLTPcoord: 27..168
e-value: 2.6E-26
score: 92.7
IPR036497Glycolipid transfer protein superfamilyGENE3DG3DSA:1.10.3520.10coord: 24..203
e-value: 5.6E-34
score: 119.3
IPR036497Glycolipid transfer protein superfamilySUPERFAMILYSSF110004Glycolipid transfer protein, GLTPcoord: 16..205
NoneNo IPR availablePANTHERPTHR10219GLYCOLIPID TRANSFER PROTEIN-RELATEDcoord: 26..200
NoneNo IPR availablePANTHERPTHR10219:SF25PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3-RELATEDcoord: 26..200