PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Overview
NamePAN2-PAN3 deadenylation complex catalytic subunit PAN2
Smed IDSMED30015376
Length (bp)1723
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (SMED30015376) t-SNE clustered cells

Violin plots show distribution of expression levels for PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (SMED30015376) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (SMED30015376) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (SMED30015376) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015376

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30015376SMESG000032598.1 SmedASXL_019537SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30015376SMESG000032598.1 SmedASXL_019537SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
epidermisSMED30015376SMESG000032598.1 dd_Smed_v4_5380_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Match: PAN2 (poly(A) specific ribonuclease subunit PAN2 [Source:HGNC Symbol;Acc:HGNC:20074])

HSP 1 Score: 130.183 bits (326), Expect = 8.036e-31
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Match: PAN2 (poly(A) specific ribonuclease subunit PAN2 [Source:HGNC Symbol;Acc:HGNC:20074])

HSP 1 Score: 129.798 bits (325), Expect = 8.394e-31
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Match: PAN2 (poly(A) specific ribonuclease subunit PAN2 [Source:HGNC Symbol;Acc:HGNC:20074])

HSP 1 Score: 129.798 bits (325), Expect = 8.956e-31
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Match: PAN2 (poly(A) specific ribonuclease subunit PAN2 [Source:HGNC Symbol;Acc:HGNC:20074])

HSP 1 Score: 129.798 bits (325), Expect = 8.956e-31
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Match: PAN2 (poly(A) specific ribonuclease subunit PAN2 [Source:HGNC Symbol;Acc:HGNC:20074])

HSP 1 Score: 129.798 bits (325), Expect = 8.956e-31
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Celegans
Match: panl-2 (PAN (PolyA-specific riboNucLease) subunit [Source:RefSeq peptide;Acc:NP_498519])

HSP 1 Score: 109.383 bits (272), Expect = 1.145e-24
Identity = 110/402 (27.36%), Postives = 173/402 (43.03%), Query Frame = 2 
Query:  236 SNNEVKALKFDPHEELLWCISTSGHLCAFYEYN-LTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFS---HHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQ--------HAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFG--QNH--------LTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSK--LSSDWPAELSSKRYRKINP 1369
            + N V  +KFDPHE+L W  S++G + +    N  T+  +  V  ++      ++ L        P + L++ L +  L    + G      KFT+      +   H P  S+ I+ G    +   D   +++I   +L       ++RYN     GT+     T D R  + ++        H    H + + DF V  +G  +ITCG    N+    DQF+KVYDLR  K   PI +   P F RFMP + + + +   T   Q        NH        L    + A    E   I A D SSN   IA G   G++++ ++  D  ++N  S +T+F   P    + S + DD     ++  F + PL    FS+  L SDWP EL+   YR+  P
Sbjct:   24 TENTVSCVKFDPHEDLFWIGSSTGKVTSLLPTNHFTRYSAFVVSNIS-----GVHSL-------EPTESLIFTLSDTMLRATTRQGI--PVAKFTSPSMTKMAASCHMPGTSTFIMGGFQEKLIHYDFVKEKEIRTTELKASENAIIIRYN-----GTN---TFTADTRGNVFVKNSKNCETIHTLDCHQDQVLDFDV--QGNKLITCGV-SMNRLKNMDQFIKVYDLRMYKALSPIGMPYLPQFARFMPSYCERVCVTYQTMYNQPGQTATWSNHPAGVKMFDLNSNGNSAEFPIETSLISAFDFSSNKNFIAVGNHCGIVNVFAD-RDQPQVNENSKETVFAAPPVQPPL-SFAIDD-----TTQTFGSIPLG---FSQEPLVSDWPTELTQIVYRRRKP 390
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Fly
Match: PAN2 (gene:FBgn0033352 transcript:FBtr0339303)

HSP 1 Score: 123.635 bits (309), Expect = 4.822e-29
Identity = 109/385 (28.31%), Postives = 178/385 (46.23%), Query Frame = 2 
Query:  248 VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELL--IYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT-IKAIDISSNSKLIAFGTSGGLISL-SSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFS 1390
            V ++ FD +EELLW  +  GH+ ++Y  ++ K  S +V               DI   ++ +D  V  L +  L   I +    F  +     +        P++   ++ GL   + + DL T ++     +   G T L + +R L  G   G V   DL + +S+QH  K H+N LSDF+V  +G  +I+CG       L  D+FL VYDLR  +   PI+V + P  ++F+P     + + SS GQ Q+ +  +  L+ P      IN   +   + DISS+S+ +AFG   G I++ ++      + N  S  T F  +   + M S++  D  F +SS   V  P      ++  SDWP EL   RY +   +D  + S
Sbjct:   64 VSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQV------------HATDIVRDISTLDSGVLALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRL--VMAGLQDELIDFDLRTLKETRIEHVGAGGCTVLRKNSRYLFAGDQLGTVTLRDL-NSLSVQHTIKTHTNILSDFSV--QGNLLISCGYSGRQNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVE--LSEPRVSMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVSIT--DTNFPLSS---VMLP-HLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLS 423
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Fly
Match: PAN2 (gene:FBgn0033352 transcript:FBtr0088654)

HSP 1 Score: 123.635 bits (309), Expect = 4.867e-29
Identity = 109/385 (28.31%), Postives = 178/385 (46.23%), Query Frame = 2 
Query:  248 VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELL--IYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT-IKAIDISSNSKLIAFGTSGGLISL-SSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFS 1390
            V ++ FD +EELLW  +  GH+ ++Y  ++ K  S +V               DI   ++ +D  V  L +  L   I +    F  +     +        P++   ++ GL   + + DL T ++     +   G T L + +R L  G   G V   DL + +S+QH  K H+N LSDF+V  +G  +I+CG       L  D+FL VYDLR  +   PI+V + P  ++F+P     + + SS GQ Q+ +  +  L+ P      IN   +   + DISS+S+ +AFG   G I++ ++      + N  S  T F  +   + M S++  D  F +SS   V  P      ++  SDWP EL   RY +   +D  + S
Sbjct:   64 VSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQV------------HATDIVRDISTLDSGVLALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRL--VMAGLQDELIDFDLRTLKETRIEHVGAGGCTVLRKNSRYLFAGDQLGTVTLRDL-NSLSVQHTIKTHTNILSDFSV--QGNLLISCGYSGRQNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVE--LSEPRVSMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVSIT--DTNFPLSS---VMLP-HLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLS 423
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Zebrafish
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:ZFIN;Acc:ZDB-GENE-030131-3113])

HSP 1 Score: 123.635 bits (309), Expect = 5.914e-29
Identity = 121/450 (26.89%), Postives = 195/450 (43.33%), Query Frame = 2 
Query:  113 GSYADGFYGTHYNLNDNNSVDCRVD-----------NGTMYQVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT------IKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVD 1375
            G YA G +G       ++S+D R+D           +G     S   ++G+YS            V A  FD  EELLW  +  GH  +F+   + +  S +V      +TDDI         +  MD  V  L +N L    + G   F   ++  AD           ++ ++ GL   + E+DL T Q+  +  +   G   + + +R   CG   G+V   DLR    ++H F   S  LSDF ++  G  +  CG + R    L  D+FL VYDLR  +   P++V + P F+RF+P +   + + S TGQ Q           P+  A L + +        + + D+SS+ + ++FG SGG + L S+   ++  N+ S DT         S+  + ++     +S    +  PL   +   L SDWP  L +   R+  PVD
Sbjct:   12 GDYAPGLHGG-LEPGLDSSLDPRLDPALLQGVEIDPDGLAVSESVHIVEGMYSELHSVAAEVGIPVTATHFDLQEELLWMGNHRGHASSFFGPTMGRYSSFQV-----HMTDDIRH-------IQSMDTGVLFLTKNNLRCLTRGGFIMFDYPMEEGADMHSLILTE--NNTLLMGGLQNYVAELDLTTVQETQKFTVEVPGVAIMRQTSRFFFCGHTSGKVSLRDLRT-FKMEHEFDAFSGSLSDFDIH--GNLLAACGFSSRGLNGLSCDRFLMVYDLRMMRAVTPLQVHVDPLFLRFIPTYTSRLAIISQTGQCQFCE--------PTGLASLADIFHVNTVGQLLMSFDVSSSKQALSFGDSGGCVHLWSS-APEVSYNSYSRDTELALPCLVDSLPQMDWNHELMPLS---LLPMPLTSTE--PLLSDWPTALIAPSPRRAPPVD 429
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Zebrafish
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:ZFIN;Acc:ZDB-GENE-030131-3113])

HSP 1 Score: 123.635 bits (309), Expect = 5.914e-29
Identity = 121/450 (26.89%), Postives = 195/450 (43.33%), Query Frame = 2 
Query:  113 GSYADGFYGTHYNLNDNNSVDCRVD-----------NGTMYQVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT------IKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVD 1375
            G YA G +G       ++S+D R+D           +G     S   ++G+YS            V A  FD  EELLW  +  GH  +F+   + +  S +V      +TDDI         +  MD  V  L +N L    + G   F   ++  AD           ++ ++ GL   + E+DL T Q+  +  +   G   + + +R   CG   G+V   DLR    ++H F   S  LSDF ++  G  +  CG + R    L  D+FL VYDLR  +   P++V + P F+RF+P +   + + S TGQ Q           P+  A L + +        + + D+SS+ + ++FG SGG + L S+   ++  N+ S DT         S+  + ++     +S    +  PL   +   L SDWP  L +   R+  PVD
Sbjct:   12 GDYAPGLHGG-LEPGLDSSLDPRLDPALLQGVEIDPDGLAVSESVHIVEGMYSELHSVAAEVGIPVTATHFDLQEELLWMGNHRGHASSFFGPTMGRYSSFQV-----HMTDDIRH-------IQSMDTGVLFLTKNNLRCLTRGGFIMFDYPMEEGADMHSLILTE--NNTLLMGGLQNYVAELDLTTVQETQKFTVEVPGVAIMRQTSRFFFCGHTSGKVSLRDLRT-FKMEHEFDAFSGSLSDFDIH--GNLLAACGFSSRGLNGLSCDRFLMVYDLRMMRAVTPLQVHVDPLFLRFIPTYTSRLAIISQTGQCQFCE--------PTGLASLADIFHVNTVGQLLMSFDVSSSKQALSFGDSGGCVHLWSS-APEVSYNSYSRDTELALPCLVDSLPQMDWNHELMPLS---LLPMPLTSTE--PLLSDWPTALIAPSPRRAPPVD 429
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Match: pex11a (peroxisomal biogenesis factor 11 alpha [Source:Xenbase;Acc:XB-GENE-970930])

HSP 1 Score: 136.732 bits (343), Expect = 5.019e-33
Identity = 117/420 (27.86%), Postives = 189/420 (45.00%), Query Frame = 2 
Query:  215 TFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPY----KSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            + M+G+YS  +         V A+ FD HEE+LW  +  GH  +F+ ++L +  S +V       ++DI ++  ++ GV         L +N L    + G     I F     +   +H       S+ ++ G+   I +MDL T Q+  +  +   G T + + NR   CG   G++   DLR     +H F  +S  LSDF ++  G  V+TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S  GQ Q        L  P+D   +      I + D+SS+ +++AFG SGG   L ++   D   N  S DT F       ++  + +      +S    +  PL       + SDWPA  S+   R+  PVD  +    +   +   IG  P
Sbjct:   54 SMMEGMYSELQTAVSEVGVPVSAVHFDLHEEMLWVGNHGGHATSFFGHDLERYSSFQV-----HGSNDIRQIQSLENGV-------MFLTKNNLKCMTRGG----LIIFDYLMDENIDNHSLLLTDNSTLLLGGMQNHIIQMDLNTVQETQKYTVEIPGITIMRQSNRFFFCGHTSGKLSLRDLRT-FKTEHEFDAYSGSLSDFDIH--GNLVVTCGFSSRMNVLACDRFLKVYDLRMMRAITPLQVHVDPLFLRFIPTYTSRLAIISQRGQCQFCE--PTGLASPADIFHVSTVSQAIMSFDVSSSKQVLAFGDSGGCTHLWAD-TPDATFNTYSRDTEFALPCMVDNLPHLDWIQDLMPLS---LIPMPLTN---ETILSDWPAVNSTPAPRRAPPVDSEILRNMK---QVGFIGYSP 442
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Match: pex11a (peroxisomal biogenesis factor 11 alpha [Source:Xenbase;Acc:XB-GENE-970930])

HSP 1 Score: 136.732 bits (343), Expect = 5.247e-33
Identity = 114/400 (28.50%), Postives = 183/400 (45.75%), Query Frame = 2 
Query:  215 TFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPY----KSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVD 1375
            + M+G+YS  +         V A+ FD HEE+LW  +  GH  +F+ ++L +  S +V       ++DI ++  ++ GV         L +N L    + G     I F     +   +H       S+ ++ G+   I +MDL T Q+  +  +   G T + + NR   CG   G++   DLR     +H F  +S  LSDF ++  G  V+TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S  GQ Q        L  P+D   +      I + D+SS+ +++AFG SGG   L ++   D   N  S DT F       ++  + +      +S    +  PL       + SDWPA  S+   R+  PVD
Sbjct:   54 SMMEGMYSELQTAVSEVGVPVSAVHFDLHEEMLWVGNHGGHATSFFGHDLERYSSFQV-----HGSNDIRQIQSLENGV-------MFLTKNNLKCMTRGG----LIIFDYLMDENIDNHSLLLTDNSTLLLGGMQNHIIQMDLNTVQETQKYTVEIPGITIMRQSNRFFFCGHTSGKLSLRDLRT-FKTEHEFDAYSGSLSDFDIH--GNLVVTCGFSSRMNVLACDRFLKVYDLRMMRAITPLQVHVDPLFLRFIPTYTSRLAIISQRGQCQFCE--PTGLASPADIFHVSTVSQAIMSFDVSSSKQVLAFGDSGGCTHLWAD-TPDATFNTYSRDTEFALPCMVDNLPHLDWIQDLMPLS---LIPMPLTN---ETILSDWPAVNSTPAPRRAPPVD 425
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Match: pex11a (peroxisomal biogenesis factor 11 alpha [Source:Xenbase;Acc:XB-GENE-970930])

HSP 1 Score: 136.346 bits (342), Expect = 5.518e-33
Identity = 117/420 (27.86%), Postives = 189/420 (45.00%), Query Frame = 2 
Query:  215 TFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPY----KSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            + M+G+YS  +         V A+ FD HEE+LW  +  GH  +F+ ++L +  S +V       ++DI ++  ++ GV         L +N L    + G     I F     +   +H       S+ ++ G+   I +MDL T Q+  +  +   G T + + NR   CG   G++   DLR     +H F  +S  LSDF ++  G  V+TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S  GQ Q        L  P+D   +      I + D+SS+ +++AFG SGG   L ++   D   N  S DT F       ++  + +      +S    +  PL       + SDWPA  S+   R+  PVD  +    +   +   IG  P
Sbjct:   54 SMMEGMYSELQTAVSEVGVPVSAVHFDLHEEMLWVGNHGGHATSFFGHDLERYSSFQV-----HGSNDIRQIQSLENGV-------MFLTKNNLKCMTRGG----LIIFDYLMDENIDNHSLLLTDNSTLLLGGMQNHIIQMDLNTVQETQKYTVEIPGITIMRQSNRFFFCGHTSGKLSLRDLRT-FKTEHEFDAYSGSLSDFDIH--GNLVVTCGFSSRMNVLACDRFLKVYDLRMMRAITPLQVHVDPLFLRFIPTYTSRLAIISQRGQCQFCE--PTGLASPADIFHVSTVSQAIMSFDVSSSKQVLAFGDSGGCTHLWAD-TPDATFNTYSRDTEFALPCMVDNLPHLDWIQDLMPLS---LIPMPLTN---ETILSDWPAVNSTPAPRRAPPVDSEILRNMK---QVGFIGYSP 442
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Match: pex11a (peroxisomal biogenesis factor 11 alpha [Source:Xenbase;Acc:XB-GENE-970930])

HSP 1 Score: 136.346 bits (342), Expect = 5.529e-33
Identity = 118/420 (28.10%), Postives = 188/420 (44.76%), Query Frame = 2 
Query:  215 TFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPY----KSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            + M+G+YS  +         V A+ FD HEE+LW  +  GH  +F+ ++L +  S +V   N     DI ++  ++ GV         L +N L    + G     I F     +   +H       S+ ++ G+   I +MDL T Q+  +  +   G T + + NR   CG   G++   DLR     +H F  +S  LSDF ++  G  V+TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S  GQ Q        L  P+D   +      I + D+SS+ +++AFG SGG   L ++   D   N  S DT F       ++  + +      +S    +  PL       + SDWPA  S+   R+  PVD  +    +   +   IG  P
Sbjct:   54 SMMEGMYSELQTAVSEVGVPVSAVHFDLHEEMLWVGNHGGHATSFFGHDLERYSSFQVHGSN-----DIRQIQSLENGV-------MFLTKNNLKCMTRGG----LIIFDYLMDENIDNHSLLLTDNSTLLLGGMQNHIIQMDLNTVQETQKYTVEIPGITIMRQSNRFFFCGHTSGKLSLRDLRT-FKTEHEFDAYSGSLSDFDIH--GNLVVTCGFSSRMNVLACDRFLKVYDLRMMRAITPLQVHVDPLFLRFIPTYTSRLAIISQRGQCQFCE--PTGLASPADIFHVSTVSQAIMSFDVSSSKQVLAFGDSGGCTHLWAD-TPDATFNTYSRDTEFALPCMVDNLPHLDWIQDLMPLS---LIPMPLTN---ETILSDWPAVNSTPAPRRAPPVDSEILRNMK---QVGFIGYSP 442
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Match: pex11a (peroxisomal biogenesis factor 11 alpha [Source:Xenbase;Acc:XB-GENE-970930])

HSP 1 Score: 136.346 bits (342), Expect = 5.694e-33
Identity = 117/420 (27.86%), Postives = 189/420 (45.00%), Query Frame = 2 
Query:  215 TFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPY----KSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            + M+G+YS  +         V A+ FD HEE+LW  +  GH  +F+ ++L +  S +V       ++DI ++  ++ GV         L +N L    + G     I F     +   +H       S+ ++ G+   I +MDL T Q+  +  +   G T + + NR   CG   G++   DLR     +H F  +S  LSDF ++  G  V+TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S  GQ Q        L  P+D   +      I + D+SS+ +++AFG SGG   L ++   D   N  S DT F       ++  + +      +S    +  PL       + SDWPA  S+   R+  PVD  +    +   +   IG  P
Sbjct:   54 SMMEGMYSELQTAVSEVGVPVSAVHFDLHEEMLWVGNHGGHATSFFGHDLERYSSFQV-----HGSNDIRQIQSLENGV-------MFLTKNNLKCMTRGG----LIIFDYLMDENIDNHSLLLTDNSTLLLGGMQNHIIQMDLNTVQETQKYTVEIPGITIMRQSNRFFFCGHTSGKLSLRDLRT-FKTEHEFDAYSGSLSDFDIH--GNLVVTCGFSSRMNVLACDRFLKVYDLRMMRAITPLQVHVDPLFLRFIPTYTSRLAIISQRGQCQFCE--PTGLASPADIFHVSTVSQAIMSFDVSSSKQVLAFGDSGGCTHLWAD-TPDATFNTYSRDTEFALPCMVDNLPHLDWIQDLMPLS---LIPMPLTN---ETILSDWPAVNSTPAPRRAPPVDSEILRNMK---QVGFIGYSP 442
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Mouse
Match: Pan2 (PAN2 poly(A) specific ribonuclease subunit [Source:MGI Symbol;Acc:MGI:1918984])

HSP 1 Score: 128.642 bits (322), Expect = 1.676e-30
Identity = 121/429 (28.21%), Postives = 183/429 (42.66%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V        DDI ++  ++ G+         L +N L    + G   F   +    D           S+ +V GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGGDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTD--NSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRS-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DALLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Mouse
Match: Pan2 (PAN2 poly(A) specific ribonuclease subunit [Source:MGI Symbol;Acc:MGI:1918984])

HSP 1 Score: 128.642 bits (322), Expect = 1.683e-30
Identity = 121/429 (28.21%), Postives = 183/429 (42.66%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V        DDI ++  ++ G+         L +N L    + G   F   +    D           S+ +V GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGGDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTD--NSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRS-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DALLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Mouse
Match: Pan2 (PAN2 poly(A) specific ribonuclease subunit [Source:MGI Symbol;Acc:MGI:1918984])

HSP 1 Score: 113.235 bits (282), Expect = 1.290e-25
Identity = 90/300 (30.00%), Postives = 137/300 (45.67%), Query Frame = 2 
Query:  557 SSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            S+ +V GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:  149 STLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRS-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DALLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 426
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Match: sp|Q504Q3|PAN2_HUMAN (PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Homo sapiens OX=9606 GN=PAN2 PE=1 SV=3)

HSP 1 Score: 129.798 bits (325), Expect = 4.301e-30
Identity = 120/427 (28.10%), Postives = 183/427 (42.86%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G          ++          S+ +V GL   I E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRT-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DTLLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Match: sp|Q5F450|PAN2_CHICK (PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Gallus gallus OX=9031 GN=PAN2 PE=2 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 6.151e-30
Identity = 111/397 (27.96%), Postives = 182/397 (45.84%), Query Frame = 2 
Query:  248 VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRL-VYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            V    FD HEE+LW  +  GH  +F+   L +  S +V       +DDI ++  ++ GV  + +  +  +    L+I+       D +   A+           S+ +V GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR  + ++H F  +S  LSDF V+  G  ++TCG       L  D+FLKVYDLR  +   P++V + P F+RF+P +   + + S TGQ Q        L +P+D   +      I   D+S++ + +AFG S G + L ++   ++  N  S +T F       ++  + ++     +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   76 VSVSHFDLHEEMLWVGNHGGHATSFFGPTLERYSSFQV-----NSSDDIRQIQSLESGVLFLTKTNLKCMSRGGLIIF-------DYLMDEAEDMHSLLLT-DSSTLLVGGLQNHVIEIDLNTVQETQKYTVEVPGITIMRQSNRFFFCGHTSGKVSLRDLRTFV-VEHEFDAYSGSLSDFDVH--GNLLVTCGFSSRMNGLACDRFLKVYDLRMMRATTPLQVHIDPFFLRFIPTYTSRLAIISQTGQCQFCE--PTGLANPADIFHVNTVGPLIMTFDVSASKQALAFGDSEGCVHLWAD-SPEVTFNTYSRETDFALPCIVDTLPHLDWNQDLVPLS---LIPVPLTS---ETLLSDWPAANSAPAPRRAPPVDPEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Match: sp|Q8BGF7|PAN2_MOUSE (PAN2-PAN3 deadenylation complex catalytic subunit Pan2 OS=Mus musculus OX=10090 GN=Pan2 PE=1 SV=1)

HSP 1 Score: 128.642 bits (322), Expect = 1.177e-29
Identity = 121/429 (28.21%), Postives = 183/429 (42.66%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD HEE+LW  S  GH  +F+   L +  S +V        DDI ++  ++ G+         L +N L    + G   F   +    D           S+ +V GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+  + +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGGDDIRQIQSLENGI-------LFLTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTD--NSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRS-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPPLDWSQDLLPLS---LIPVPLTT---DALLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Match: sp|Q6IE70|PAN2_RAT (PAN2-PAN3 deadenylation complex catalytic subunit Pan2 OS=Rattus norvegicus OX=10116 GN=Pan2 PE=2 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 3.934e-29
Identity = 118/429 (27.51%), Postives = 185/429 (43.12%), Query Frame = 2 
Query:  203 QVSQTFMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVL--GLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSD-------GALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKP 1435
            Q S   M+G+YS            V    FD  EE+LW  S  GH  +F+   L +  S +V       +DDI ++  ++ G+         L +N L    + G       +  D+ +         ++ +L  GL   + E+DL T Q+  +  +   G T + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG       L  D+FLKVYDLR  +   P++V + PAF+RF+P +   + + S +GQ Q        L +P+D       G LL+         D+S++ + +AFG S G + L ++  +    N  S +T F       S+ ++ +      +S    +  PL       L SDWPA  S+   R+  PVD  +    +   K   IG  P
Sbjct:   52 QESVHIMEGVYSELHSVVAEVGVPVSVSHFDLQEEMLWVGSHGGHATSFFGPALERYSSFQV-----NGSDDIRQIQSLENGI-------LFLTKNNLKYMARGGLII--FDYLLDESEDMHSLLLADNNTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRS-FKVEHEFDAFSGSLSDFDVH--GNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCE--PTGLANPADIFHVNPVGPLLMT-------FDVSASKQALAFGDSEGCVHLWTDSPEP-SFNPYSRETEFALPCLVDSLPALDWSQDLLPLS---LIPVPLTT---DALLSDWPAANSAPAPRRAPPVDAEILRTMK---KVGFIGYAP 444
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Match: sp|A1Z7K9|PAN2_DROME (PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Drosophila melanogaster OX=7227 GN=PAN2 PE=1 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 4.879e-28
Identity = 109/385 (28.31%), Postives = 178/385 (46.23%), Query Frame = 2 
Query:  248 VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELL--IYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT-IKAIDISSNSKLIAFGTSGGLISL-SSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFS 1390
            V ++ FD +EELLW  +  GH+ ++Y  ++ K  S +V               DI   ++ +D  V  L +  L   I +    F  +     +        P++   ++ GL   + + DL T ++     +   G T L + +R L  G   G V   DL + +S+QH  K H+N LSDF+V  +G  +I+CG       L  D+FL VYDLR  +   PI+V + P  ++F+P     + + SS GQ Q+ +  +  L+ P      IN   +   + DISS+S+ +AFG   G I++ ++      + N  S  T F  +   + M S++  D  F +SS   V  P      ++  SDWP EL   RY +   +D  + S
Sbjct:   64 VSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQV------------HATDIVRDISTLDSGVLALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRL--VMAGLQDELIDFDLRTLKETRIEHVGAGGCTVLRKNSRYLFAGDQLGTVTLRDL-NSLSVQHTIKTHTNILSDFSV--QGNLLISCGYSGRQNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVE--LSEPRVSMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVSIT--DTNFPLSS---VMLP-HLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLS 423
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Match: A0A4S2LDU7 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008003 PE=4 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 3.465e-36
Identity = 102/346 (29.48%), Postives = 159/346 (45.95%), Query Frame = 2 
Query:  191 GTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDD----IYELLDIQIGVNPMDRLVYILGENELLIYKKTG-SFRDRIKFTADQCKCFS-HHPYKSSS--------------------IVLGLHAGITEMD-LETKQQITELKLPNFGTTALLR-YNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRC-NQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISL 1141
            G  +      M+G++ ++ V  + FDP EEL+WCI+  G L AF+  +L + ++  +P L     D+    + EL  I     P +  VY+L  N L  Y K G      +       +C +   P  ++                      + GL   I E+D L+   ++        G + +LR ++ GL  G  +G+V+ +D R    I      H+  +SD TV   GY ++TCG  R  +  L  D+ LKVYDLR  + Q P+   + P F RF P   D +L AS  G +Q   +G   L+ P+D   L   YD + A+DIS+N+  + FGT  G + L
Sbjct:   46 GGYWLTGTQIMNGVFPSDNVADVAFDPLEELVWCITRMGQLTAFFSVSLERYITTNIPLLPNTYMDEGGSHLGELKQIYPSPRPPEHAVYMLASNALHAYTKFGRPITCAVNKLMVDLECLTVTGPTGATPGLGMGGGVWGTANEAEFCRIFLGGLQPNILELDALDRWGEVIRTIDVGLGGSVVLRSFSSGLCAGNTNGKVMVIDARTPNGIVRELDAHTGEISDITVVPHGYTLVTCGWSRLQDSGLRMDRLLKVYDLRSGRAQVPLSASLDPCFARFFPGCTDRLLAASQAGGFQTIQWGTRVLS-PNDIGQLWPSYDRLVALDISNNANGLVFGTETGHLQL 390
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Match: H2KS93 (PAB-dependent poly(A)-specific ribonuclease subunit 2 OS=Clonorchis sinensis OX=79923 GN=Pan2 PE=4 SV=1)

HSP 1 Score: 154.066 bits (388), Expect = 3.574e-36
Identity = 103/346 (29.77%), Postives = 157/346 (45.38%), Query Frame = 2 
Query:  191 GTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDD----IYELLDIQIGVNPMDRLVYILGENELLIYKK---------------------TGSFRDRIKFTADQCKCFSHHPYKSSSIVLG-LHAGITEMD-LETKQQITELKLPNFGTTALLR-YNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRC-NQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISL 1141
            G  +      M+G++ ++ V  + FDP EEL+WCI+  G L AF+  +L + ++  +P L     D+    + EL  I     P +  VY+L  N L  Y K                     TG                + +  +   I LG L   I E+D L+   ++        G + +LR ++ G+  GT +G+V+ +D R    I      H+  +SD TV   GY ++TCG  R  +  L  D+ LKVYDLR  + Q P+   + P F RF P   D +L AS  G +Q   +G   L+ P+D   L   YD + A+DIS N+  + FGT  G + L
Sbjct:   46 GGYWLTGTQIMNGVFPSDNVADVAFDPLEELVWCITRMGQLTAFFSVSLERYITTNIPLLPNTYMDEGGSHLGELKQIYPSPRPPEHAVYMLASNALHAYTKFGRPITCAVNKLMVDLECLTVTGPTGATPGLGMGGGVWGTANEAEFCRIFLGGLQPNILELDALDRWGEVIRTIDVGLGGSVVLRSFSSGMCAGTTNGKVMVIDARTPNGIVRELDAHTGEISDITVVPHGYTLVTCGWSRLQDSGLRMDRLLKVYDLRSGRAQVPLSASLDPCFARFFPGCTDRLLAASQAGGFQTIQWGTRVLS-PNDIGQLWPSYDRLVALDISHNANGLVFGTETGHLQL 390
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Match: R7UIQ4 (PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Capitella teleta OX=283909 GN=PAN2 PE=3 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 4.339e-36
Identity = 123/397 (30.98%), Postives = 195/397 (49.12%), Query Frame = 2 
Query:  200 YQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTA---DQCKCFSHHPYKSSSIVLGLHAGI-TEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLIN-EYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVD 1375
            +++  + +DG      V A+ FD  EELLW  +  GH+ ++Y  +  K  S +V E     T++I +LL +       D LV+ L  + L    K G  + R K  A    QC   +  P+K   I++G H  I  E+D+E +++I ++++   G  A+LR++   +C  D    +TL     +  QH  + HS  LSDF V      ++TCG       L  D+FL +YDLRY K   P+ + + P F+RF+P+++D I + S  GQ+Q+    Q  LT  S     +  E  +I A DIS + + +AFG +GG I L     +   +N  S DT F  +    +   V+     + +   ++ A+        KL+SDWP EL  K YRK   +D
Sbjct:   42 FEIKNSMVDG-GDRFSVSAVAFDGQEELLWMGNQGGHVTSYYGLDPQKYTSFQVHE-----TNEIRQLLTV-------DGLVFSLTPDSLRCNSKYGRPQYRHKSDALQDMQCMLLTQ-PHK---ILMGGHQPIMVELDIEKRKEIRQVEISEPGC-AILRFSTQYICSGDTAGKVTLRDPRSLKTQHVLQAHSGTLSDFDVCNN--QLVTCGFSNRMGSLTADRFLMLYDLRYMKATTPMPMTLDPMFLRFIPMYSDRICVVSQIGQFQVME--QGALTPASMTVYNVQTEGASINAFDISPSHQTMAFGDAGGFIHLFGT--ETPVMNPFSKDTEFAPVETLHASIDVNNLLAPYSLVPMQYPAQ-------GKLASDWPEELCQKTYRKAPRID 407
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Match: A0A4S2LD81 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008003 PE=4 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 5.448e-36
Identity = 103/346 (29.77%), Postives = 157/346 (45.38%), Query Frame = 2 
Query:  191 GTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDD----IYELLDIQIGVNPMDRLVYILGENELLIYKK---------------------TGSFRDRIKFTADQCKCFSHHPYKSSSIVLG-LHAGITEMD-LETKQQITELKLPNFGTTALLR-YNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRC-NQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISL 1141
            G  +      M+G++ ++ V  + FDP EEL+WCI+  G L AF+  +L + ++  +P L     D+    + EL  I     P +  VY+L  N L  Y K                     TG                + +  +   I LG L   I E+D L+   ++        G + +LR ++ GL  G  +G+V+ +D R    I      H+  +SD TV   GY ++TCG  R  +  L  D+ LKVYDLR  + Q P+   + P F RF P   D +L AS  G +Q   +G   L+ P+D   L   YD + A+DIS+N+  + FGT  G + L
Sbjct:   46 GGYWLTGTQIMNGVFPSDNVADVAFDPLEELVWCITRMGQLTAFFSVSLERYITTNIPLLPNTYMDEGGSHLGELKQIYPSPRPPEHAVYMLASNALHAYTKFGRPITCAVNKLMVDLECLTVTGPTGATPGLGMGGGVWGTANEAEFCRIFLGGLQPNILELDALDRWGEVIRTIDVGLGGSVVLRSFSSGLCAGNTNGKVMVIDARTPNGIVRELDAHTGEISDITVVPHGYTLVTCGWSRLQDSGLRMDRLLKVYDLRSGRAQVPLSASLDPCFARFFPGCTDRLLAASQAGGFQTIQWGTRVLS-PNDIGQLWPSYDRLVALDISNNANGLVFGTETGHLQL 390
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Match: C1LFL7 (PAB-dependent poly(A)-specific ribonuclease subunit 2 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 152.91 bits (385), Expect = 1.173e-35
Identity = 97/343 (28.28%), Postives = 162/343 (47.23%), Query Frame = 2 
Query:  191 GTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVP---ELNKKLTDDIY-ELLDIQIGVNPMDRLVYILGENELLIYKKTG-SFRDRIKFTADQCKCFS---------HHPYKSSSIVLG---------LHAGITEMDLETK--QQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRC-NQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISL 1141
            G  + +    MD ++  + +  + FDP EEL+WC++ +G + AFY   + + +++ VP   ++N   T   Y EL  +     PM+  V++L  N L  Y K G      +     + +C +             + S   +G         L   + E+D   +  + I  + +   G+  L  ++ GL  G  +G+V+ +D R    I      H+  +SD TV+A  + ++TCG  R  +  L  D+ L+VYDLR  + Q P+   + P FVRF+P  +DS+L  S TG +Q   +G+   + P+D   L   YD + A DIS N   +AF T  G + L
Sbjct:   57 GGYWHIGTQMMDCLFQTDRIADVTFDPLEELIWCVTRAGQMSAFYSTTMERYITLTVPLLSDVNSFETVTPYNELKQVFPSPRPMEHSVFVLANNALHAYTKMGRPLASAVNKFMLELECLAVTGPTGTLAGSGIRGSGCAIGNFARFFLGGLQPTLLEVDAVERWGEVINTIDVGIGGSVVLRPFSGGLCAGNTNGKVMIIDSRTSHGIVRELDAHTGEISDMTVDANSHTLVTCGWSRVGDSGLRVDRLLRVYDLRSGRAQVPLSASLDPCFVRFIPGCSDSLLATSQTGAFQTIQWGKLAFS-PNDLGQLWLGYDRLVATDISQNGNCVAFATEAGQLHL 398
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Cavefish
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:ZFIN;Acc:ZDB-GENE-030131-3113])

HSP 1 Score: 116.316 bits (290), Expect = 1.050e-26
Identity = 111/388 (28.61%), Postives = 175/388 (45.10%), Query Frame = 2 
Query:  248 VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTG--SFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDT------IKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAEL--SSKRYRKI-NPVD 1375
            V A  FD  EELLW  +  GH  +F+   + +  S +V      LTDDI         +  MD  V  L ++ L    + G   F   ++  AD           ++ I+ GL   + E+DL T Q+  +  +   G   + + NR   CG   G+V   D+R    ++H F   S  LSDF V+  G  +  CG + R    L  D+FL VYDLR  +   P++V + P F+RF+P +   + + S TGQ Q           P+  A L + +        + + D+SS+ + +AFG SGG + L S+   ++  N+ S +T         S+  + +++    +S    +  PL   +   L SDWP+ L   S RY    +PVD
Sbjct:   73 VTATHFDLQEELLWMGNHRGHASSFFGPTMGRYSSFQV-----HLTDDIRH-------IQSMDTGVLFLTKSNLKCLTRGGLIMFDYPMEEGADMHSLLLTD--NNTLIMGGLQNYVAEVDLNTVQETQKFTVEVPGVAIMRQSNRFFFCGHTSGKVSLRDMRT-FKMEHEFDAFSGSLSDFDVH--GNLLAACGFSSRGLNGLSCDRFLMVYDLRMMRAVTPLQVHVDPLFLRFIPTYTSRLAIISQTGQCQFCE--------PTGLASLADIFHVNTVGQLLMSFDVSSSKQALAFGDSGGGVHLWSS-APEVSYNDYSRETELALTCLVDSLPHLDWNNELVPLS---LLPMPLTNTE--PLLSDWPSNLVAPSPRYHLAHHPVD 429
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Sea Lamprey
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:ZFIN;Acc:ZDB-GENE-030131-3113])

HSP 1 Score: 114.005 bits (284), Expect = 1.137e-26
Identity = 85/266 (31.95%), Postives = 133/266 (50.00%), Query Frame = 2 
Query:  422 VNPMDRLVYILGENELLIYKKTGSFR-DRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILL----ASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFP 1201
            V  +D  V +L +N L  + + G    D +   A +  C       +S ++ G    I E+DL + Q++ +  +   G T + + NR   CG   G+V   D R     +H F+ HSN L DF V+  G  ++TCG T R N+ L  D+FL VYD+R  +   P++V ++PAFVRF+P +   + +    A  TGQ Q        L +P+D   +      I A D+SS+ + +AFG SGG + L ++    +  N  S +T FP
Sbjct:   28 VQSLDNGVLLLTKNNLKCFSRGGLIMCDYMTEEAHEMHCMLL-TSNNSLLIGGQQNHILELDLSSAQEMQKYDVETTGVTIMKQANRFFFCGHAGGKVTLHDPRT-FKPEHEFEAHSNNLLDFDVH--GNLLVTCGLTARLNR-LACDRFLMVYDMRMMRAVTPLQVHLEPAFVRFIPTYTSRLAIISQTAPHTGQCQFCE--PTGLANPADMMHVDTVGQLIMAFDVSSSRQALAFGDSGGCLHLWAD-SPQVTFNEYSRETEFP 285
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Medaka
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:NCBI gene;Acc:101157055])

HSP 1 Score: 115.161 bits (287), Expect = 2.358e-26
Identity = 105/395 (26.58%), Postives = 175/395 (44.30%), Query Frame = 2 
Query:   95 FQPDNYGSYADGFYGT---HYNLNDNNSVDCRVDNGTMYQVSQT-FMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVL--GLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFP------TIPQ 1213
            F P+ +G+   G   +   H N +    V+   +  TM        M+GI+S            V A  FD  EE+LW  +  GH+ +F+   + +  S +V        DDI  +  ++ GV         L ++ L  Y + G F     +  ++           ++ +L  GL   + E+DL T Q+  +  +   G   + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG + R    L  D+FL VYDLR  +   P++V + P F+RF+P +   +++ S TGQ Q        L + +D   +      + + D+SS+ + + FG SGG + L ++   ++  N+ S +T F       T+PQ
Sbjct:   13 FPPNLHGTLDAGLEPSMDPHLNPSLLQGVELEAEGLTMTVPEPVHMMEGIFSELHSVVSEVGIPVTATHFDNQEEMLWMGNHRGHVTSFFGPTMGRYSSFQV-----HAADDIRHIQSLETGV-------LFLSKSNLKCYTRGGLFM--FDYPMEEGADMHSLLMTGNNTLLMGGLQNYVAEVDLNTVQETQKFTVDIPGVAIMRQSNRFFFCGHTSGKVTLRDLRT-FKMEHEFDAFSGSLSDFDVH--GNLLAACGFSSRGLNGLSCDRFLMVYDLRMMRAVTPLQVHVDPLFLRFIPTYTSRLVIISQTGQCQFCE--PTGLANVADIFHVNTVGQLLMSFDVSSSKQALGFGDSGGCVHLWTD-VPEVSFNDYSRETEFALPCLVDTLPQ 387
[Close]
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Medaka
Match: pan2 (poly(A) specific ribonuclease subunit PAN2 [Source:NCBI gene;Acc:101157055])

HSP 1 Score: 115.161 bits (287), Expect = 2.580e-26
Identity = 105/395 (26.58%), Postives = 175/395 (44.30%), Query Frame = 2 
Query:   95 FQPDNYGSYADGFYGT---HYNLNDNNSVDCRVDNGTMYQVSQT-FMDGIYSNNE---------VKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVL--GLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCG-TYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFP------TIPQ 1213
            F P+ +G+   G   +   H N +    V+   +  TM        M+GI+S            V A  FD  EE+LW  +  GH+ +F+   + +  S +V        DDI  +  ++ GV         L ++ L  Y + G F     +  ++           ++ +L  GL   + E+DL T Q+  +  +   G   + + NR   CG   G+V   DLR    ++H F   S  LSDF V+  G  +  CG + R    L  D+FL VYDLR  +   P++V + P F+RF+P +   +++ S TGQ Q        L + +D   +      + + D+SS+ + + FG SGG + L ++   ++  N+ S +T F       T+PQ
Sbjct:   13 FPPNLHGTLDAGLEPSMDPHLNPSLLQGVELEAEGLTMTVPEPVHMMEGIFSELHSVVSEVGIPVTATHFDNQEEMLWMGNHRGHVTSFFGPTMGRYSSFQV-----HAADDIRHIQSLETGV-------LFLSKSNLKCYTRGGLFM--FDYPMEEGADMHSLLMTGNNTLLMGGLQNYVAEVDLNTVQETQKFTVDIPGVAIMRQSNRFFFCGHTSGKVTLRDLRT-FKMEHEFDAFSGSLSDFDVH--GNLLAACGFSSRGLNGLSCDRFLMVYDLRMMRAVTPLQVHVDPLFLRFIPTYTSRLVIISQTGQCQFCE--PTGLANVADIFHVNTVGQLLMSFDVSSSKQALGFGDSGGCVHLWTD-VPEVSFNDYSRETEFALPCLVDTLPQ 387
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Planmine SMEST
Match: SMESG000032598.1 (SMESG000032598.1)

HSP 1 Score: 954.896 bits (2467), Expect = 0.000e+0
Identity = 457/458 (99.78%), Postives = 458/458 (100.00%), Query Frame = 2 
Query:   92 MFQPDNYGSYADGFYGTHYNLNDNNSVDCRVDNGTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKPANWGPVWFPY 1465
            MFQPDNYGSYADGFYGTHYNLNDNNSVDCRVDNGTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQ+LTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKPANWGPVWFPY
Sbjct:    1 MFQPDNYGSYADGFYGTHYNLNDNNSVDCRVDNGTMYQVSQTFMDGIYSNNEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDDIYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFSHHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLCGTDDGQILTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCNQQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQYQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISLSSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPLDKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKPANWGPVWFPY 458
The following BLAST results are available for this feature:
BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PAN28.036e-3128.10poly(A) specific ribonuclease subunit PAN2 [Source... [more]
PAN28.394e-3128.10poly(A) specific ribonuclease subunit PAN2 [Source... [more]
PAN28.956e-3128.10poly(A) specific ribonuclease subunit PAN2 [Source... [more]
PAN28.956e-3128.10poly(A) specific ribonuclease subunit PAN2 [Source... [more]
PAN28.956e-3128.10poly(A) specific ribonuclease subunit PAN2 [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
panl-21.145e-2427.36PAN (PolyA-specific riboNucLease) subunit [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
PAN24.822e-2928.31gene:FBgn0033352 transcript:FBtr0339303[more]
PAN24.867e-2928.31gene:FBgn0033352 transcript:FBtr0088654[more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pan25.914e-2926.89poly(A) specific ribonuclease subunit PAN2 [Source... [more]
pan25.914e-2926.89poly(A) specific ribonuclease subunit PAN2 [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pex11a5.019e-3327.86peroxisomal biogenesis factor 11 alpha [Source:Xen... [more]
pex11a5.247e-3328.50peroxisomal biogenesis factor 11 alpha [Source:Xen... [more]
pex11a5.518e-3327.86peroxisomal biogenesis factor 11 alpha [Source:Xen... [more]
pex11a5.529e-3328.10peroxisomal biogenesis factor 11 alpha [Source:Xen... [more]
pex11a5.694e-3327.86peroxisomal biogenesis factor 11 alpha [Source:Xen... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Pan21.676e-3028.21PAN2 poly(A) specific ribonuclease subunit [Source... [more]
Pan21.683e-3028.21PAN2 poly(A) specific ribonuclease subunit [Source... [more]
Pan21.290e-2530.00PAN2 poly(A) specific ribonuclease subunit [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q504Q3|PAN2_HUMAN4.301e-3028.10PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
sp|Q5F450|PAN2_CHICK6.151e-3027.96PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
sp|Q8BGF7|PAN2_MOUSE1.177e-2928.21PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
sp|Q6IE70|PAN2_RAT3.934e-2927.51PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
sp|A1Z7K9|PAN2_DROME4.879e-2828.31PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2LDU73.465e-3629.48Uncharacterized protein OS=Opisthorchis felineus O... [more]
H2KS933.574e-3629.77PAB-dependent poly(A)-specific ribonuclease subuni... [more]
R7UIQ44.339e-3630.98PAN2-PAN3 deadenylation complex catalytic subunit ... [more]
A0A4S2LD815.448e-3629.77Uncharacterized protein OS=Opisthorchis felineus O... [more]
C1LFL71.173e-3528.28PAB-dependent poly(A)-specific ribonuclease subuni... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pan21.050e-2628.61poly(A) specific ribonuclease subunit PAN2 [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pan21.137e-2631.95poly(A) specific ribonuclease subunit PAN2 [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pan22.358e-2626.58poly(A) specific ribonuclease subunit PAN2 [Source... [more]
pan22.580e-2626.58poly(A) specific ribonuclease subunit PAN2 [Source... [more]
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BLAST of PAN2-PAN3 deadenylation complex catalytic subunit PAN2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000032598.10.000e+099.78SMESG000032598.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015376 ID=SMED30015376|Name=PAN2-PAN3 deadenylation complex catalytic subunit PAN2|organism=Schmidtea mediterranea sexual|type=transcript|length=1723bp
ATTTCAATTTTTTAATATATTTTAATATTTAATTTAATTTATTTTCTTAA
TGAATTGATATTTATCTATTTAATAATTGAATTCCAAATATATGTTCCAA
CCTGATAATTATGGTAGTTATGCCGATGGGTTTTATGGGACTCATTACAA
TTTAAATGATAATAATTCAGTAGATTGTAGAGTTGACAATGGCACAATGT
ACCAGGTATCCCAGACATTCATGGATGGCATTTATTCAAACAATGAAGTG
AAAGCATTGAAATTTGATCCACACGAAGAGCTATTGTGGTGCATCAGTAC
TAGCGGTCATCTTTGTGCTTTTTATGAATATAATCTGACAAAGCTTGTGT
CGGTGGAAGTTCCCGAGCTGAATAAGAAACTGACTGATGATATTTATGAG
TTGCTGGACATCCAGATCGGTGTCAATCCAATGGATAGATTGGTGTACAT
ATTGGGCGAGAACGAATTGCTGATATACAAGAAAACCGGCTCGTTCCGCG
ACCGGATCAAGTTCACTGCCGACCAATGCAAATGCTTCTCTCACCATCCT
TACAAGAGCTCCTCAATCGTGCTCGGCCTTCATGCCGGAATCACTGAAAT
GGATCTAGAAACAAAGCAGCAAATTACAGAATTGAAATTGCCAAATTTCG
GAACAACGGCGTTATTGAGATACAACCGAGGGTTGCTATGCGGCACTGAT
GATGGGCAGGTCCTCACTCTCGACCTCCGGGACAGAATATCAATCCAGCA
CGCATTCAAGCCCCATTCCAACGGTCTCAGTGATTTCACTGTCAATGCTG
AAGGTTACGCTGTGATCACATGCGGCACATATCGGTGCAATCAACAGCTC
TACACGGATCAATTTCTCAAGGTGTACGATCTGCGCTACAAGAAACCTCA
ATGTCCAATCAAAGTTGAGATGCAGCCAGCATTCGTGCGATTTATGCCGG
TGTTCAATGACAGCATTCTGCTGGCCTCGAGCACTGGCCAATATCAGATT
GCTAATTTCGGGCAGAATCACCTGACTCACCCTAGCGACGGCGCCCTGCT
GATCAATGAATACGACACCATCAAGGCCATTGATATTTCCTCCAACTCCA
AATTGATCGCATTCGGCACGAGCGGCGGATTGATATCATTGTCATCCAAT
TGCTGTGACGACCTCAAAATTAATAACTGCTCAATCGATACGATATTCCC
CACAATACCGCAATACATGTCGATGTCCTCCGTCAGCTATGATGACCCCA
AATTCATCATTTCTTCATCGGAATTCGTTGCGGAACCTTTGGATAAATGT
AAATTCAGCAAACTCTCATCTGATTGGCCTGCTGAACTCAGTTCGAAACG
ATATCGGAAAATCAATCCGGTAGACCTGAATCTATTCTCCCAATACCAAT
CAAAATTCAAAGCAGAGTTGATTGGCCGGAAGCCAGCAAATTGGGGACCG
GTTTGGTTTCCATATTGAATTGAGAGAGCCATTTCCAATAACTGAAATAT
TTACTCTATCAATTCTCATTGGCCATGAGCCGTAGGTAGTAACCAATGAG
ATGCTGAAACAATTTGATGTATATTTATGATTGTGAATTGCTGATCTTGG
CATAGCTTTGGTGCGCTTGATGAGATTTCAGTGCTCGCATCATTTGGTCA
TGTAATTAGTTATATTTATATATTGCCATTTTGTTAATATCTCCAATCGA
TCATTTGTTGCATGCTTATGTTC
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protein sequence of SMED30015376-orf-1

>SMED30015376-orf-1 ID=SMED30015376-orf-1|Name=SMED30015376-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=459bp
MFQPDNYGSYADGFYGTHYNLNDNNSVDCRVDNGTMYQVSQTFMDGIYSN
NEVKALKFDPHEELLWCISTSGHLCAFYEYNLTKLVSVEVPELNKKLTDD
IYELLDIQIGVNPMDRLVYILGENELLIYKKTGSFRDRIKFTADQCKCFS
HHPYKSSSIVLGLHAGITEMDLETKQQITELKLPNFGTTALLRYNRGLLC
GTDDGQVLTLDLRDRISIQHAFKPHSNGLSDFTVNAEGYAVITCGTYRCN
QQLYTDQFLKVYDLRYKKPQCPIKVEMQPAFVRFMPVFNDSILLASSTGQ
YQIANFGQNHLTHPSDGALLINEYDTIKAIDISSNSKLIAFGTSGGLISL
SSNCCDDLKINNCSIDTIFPTIPQYMSMSSVSYDDPKFIISSSEFVAEPL
DKCKFSKLSSDWPAELSSKRYRKINPVDLNLFSQYQSKFKAELIGRKPAN
WGPVWFPY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0005515protein binding
GO:0003676nucleic acid binding
GO:0004518nuclease activity
GO:0004527exonuclease activity
GO:0004535poly(A)-specific ribonuclease activity
GO:0016787hydrolase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036322WD40_repeat_dom_sf
IPR015943WD40/YVTN_repeat-like_dom_sf
IPR017986WD40_repeat_dom
Vocabulary: biological process
TermDefinition
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening
GO:0006397mRNA processing
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly
GO:0090305nucleic acid phosphodiester bond hydrolysis
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic
Vocabulary: cellular component
TermDefinition
GO:0000932P-body
GO:0005634nucleus
GO:0005737cytoplasm
GO:0031251PAN complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR015943WD40/YVTN repeat-like-containing domain superfamilyGENE3DG3DSA:2.130.10.10coord: 33..353
e-value: 7.0E-45
score: 155.5
NoneNo IPR availablePANTHERPTHR15728UBIQUITIN SPECIFIC PROTEASE 52 / POLY A RIBONUCLEASE SUBUNIT PAN2coord: 37..436
IPR036322WD40-repeat-containing domain superfamilySUPERFAMILYSSF50978WD40 repeat-likecoord: 49..351