Guanylate cyclase

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSF I+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD--DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKK-IYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  +   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ +++P+LTA   AS  S K   Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    ++G+TG +++D N     D+ L  M  + +G+F     + G  K  +    R I W   K + P D P C F  D   C   P++   +  L   +  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG--RALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYAREPGGPEQATHF----IRANGRIVYICG-PLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTK 3495
            G  L+     Q+FAKTA YK N+VA+K  R+  +RIE+ R++LF++K ++D+ N H+ RF+G C DP N CI+TEYCP+GSLQD+LENE I LD +FR SL  D+ +GML+L    I  HGNLKSSNC+VD RFVLKITD+GL +FR   ++        Y  KLWTAPE+LR  + P  G    DVYSF I+ QEI  RSGVF++  +D+   +I+     + E PPFRP L  +  + +++  +++ CW EDP  RP F QI+L LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD++ ++ DVYKVETIGDAYMVVSGLP RNG +H   +A M+LA L  +  F+I H+P +QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIH+S  +K  L+ FG F L  RG+V++KGKG  +TYWL G +
Sbjct:  541 GSLLTTEGQFQVFAKTAYYKGNLVAVK--RVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR---DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVT-RGEQPPFRPSLALQSHL-EELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGER 1055          

Query:  238 IKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAV-----GPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEH-GFMNSTIANLIRIREN----ARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQ------PWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGK--KC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNS 1719
            + +AV+LP  ++       +V PA+++A+  VK   +L    T       S ++L V      PL A+D+  ++   V LGP   +  A V R++++ ++VP+LTA   A     K  Y + TR   +Y  +      +     W  ++    +  Y +   D   C F    +          F+ + D +++  +H  F    +++  R+        R+  IC+ S +  R +ML A    L   +YV+F++D+    ++G Q      PW         +V A++AF++   ++++ PD+  Y +F+ ++K  +   +N+  +    N+    FHD ++LY  A+ +TL+   ++TDGE +   +WN SF G+TG + ID +G    D+SL DMD   G F VV  + G ++ LV    R ++W       P D P CGFD +   C    ++   V  L   +  + ++I      RK +++ EL S  W++ W D+E     +  RS  S
Sbjct:   35 LTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAH-WRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQA----LMLYAYRPGDEEHCFFLVEGL----------FMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICS-SPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW---ERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWP--LGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGS 529          

Query: 1981 AIYKENIVALKHLRL----EGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXX-------XXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTE-RGNVDIKGKGIQKTYWLHGTKENIVDQLPT 3522
            AIY+ + V LK   L    + + I+     +F++  +KDL + +I   +G   D G   I+TE+C +GSL+D+L N+ +KLD +F+ SL+ D+ +GM YL      HG LKS NC+VD RFVLK+TD+G +   I   +   +     +  LWTAPE+LR P    +G    DVYSFAI+ QE++ R   F + D+           P  V   V   E+ P             + + +++ CW E    RP F +I  + +  N     +I+D++L  +EQY++NLE L+ +RT++   EK++ E LL  MLP SVA  L +G  V  E F+ VT+YFSDI GFT +SA S P++V+ LLN+LYTLFD+I   HDVYKVETIGDAYMV SGLP+RNG  H   IA MSL  LS +  FK+ H P+  ++IRIG+H+G V AGVVG+ MPRYCLFGDTVNTASRMES G P +IHVS S+   L    E    E RG  ++KGKG ++T+WL G K+  +  LP 
Sbjct:  564 AIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEM--MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFN--DILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAP------------PECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG-KKGFMKPLPV 1072          

Query:  865 RITIICAKSS----NYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMD 1383
            RI I+C  S+         ++  AH LK+T+G YV+   D     +  L   + P    +NN   +EA+ +V+T++    +   Y  F    +  ++       + D  +   G  ++++     A+N  +  N        V++   N  F+G    +  D NG G ++Y +LD +
Sbjct:  243 RIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYD---ALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAF---TEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSR-NMQFHGFNQLMRTDSNGNGISEYVILDTN 412          

Query: 1981 AIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNE----------CIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPP--FRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSK---RELDTFGEFILTERGNVDIKGKGIQKTYWLHGTK 3495
             +Y+ + V LK    + + I I          +++L + ++A ++G+ L  G E           +++E+C +GSLQD+L   +IKLD +F+ SL+ D+ +G+ YL      HG LKS NC+VD RFVLKITD G       +++         +++LWTAPE+LR+P L   G    DV+S AI+ QE++ RS  +       +      + V+++ +PP   RP +  ++    + I +++ CW E P LRP         + IN     +I+D++L  +EQY++NLE L+ +RT++   EK++ + LL  MLP SVA  L  G PV  E FE+VT+YFSDI GFT +SA S P++V+ LLN+LYTLFD+I   HDVYKVETIGDAYMV SGLPQRNG  H   IA MSL  LS +  F++ H P+  ++IRIG+H+G   AGVVG+ MPRYCLFGDTVNTASRMES G P +IHV+ S+    R LD+  +  L  RG  ++KGKG + T+WL G +
Sbjct:  553 GVYEGDRVWLKKFPGD-QHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRA--EDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPY------AMLELTPEEVVQRVRSPPPLCRPLVSMDQA-PVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVEL--RGRTELKGKGAEDTFWLVGRR 1060          

Query: 1987 YKENIVALKHLR------LEGRRIEINREILFQIKSVKDLNNNHIARFIG-ICLDPGNECIITEYCPKGSLQDVLENEQIK------LDSVFRLSLMQDMCRGMLYLQST-IGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENP----PFRPRLEDERGINKD--IISIIRSCWQEDPNLRPGFAQIKLKLRRING----AGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELD-TFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPT 3522
            Y +  V LK L+       E ++IE+N+  L QI    D  N  + +F G + LD     +I EYC +GSL++VL N+ I       +D  F++S++ D+ +GM YL S+    HG LKS+NC+VDSR V+KITDFG             +S    K  LWTAPE LR   +      K DVYS+ I+ QEII R   FY       +  I      ++EN     PFRP L  E    K+  +  ++++CW+EDP  RP F +I+  L +I G      +   +D L+ R++ Y+ NLE LV +RTQ Y  E+ RA+ L + +LP+ V   L     V  E +E+VTIYFSDI GFT +   STPM+V+ +LN++Y  FD I + HDVYKVETIGDAYMV SGLP+RNG  H   IA M+L  LS +  F++ H P   + IRIG+H+G   AGVVG+KMPRYCLFGDTVNTASRMES G PL+IHVS S+   L  T  +F+   RG   +KG+G + TYWL G K+   + LPT
Sbjct:  508 YDKKRVILKDLKHNDGNFTEKQKIELNK--LLQI----DYYN--LTKFYGTVKLDTMIFGVI-EYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGC------------NSILPPKKDLWTAPEHLRQANIS----QKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIF-----RVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFN-LPT 1012          

Query: 1957 STQMFAKTAIYKENIVALKHLRLEGR---RIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHD--SFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKI--ENPPFRPRL------EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            +TQ++ KTAI+K  +VA+K L ++ +   R++++R  L ++K +KDL ++HI RF G C+D  + C++TEYCPKGSL+D+LENE+I+LD + + SL+ D+ +G+ +L  S I  HG LKSSNC+VDSRFVLK+TDFGL       EI+  +     +YK  LWTAPE+LR+   PP+G  K D+YSFAI+  E+++R GVF + + D+   +IV    + +  +  P RP +      E +  +N  ++S++ +CW EDP+ RP  + ++  +R +N   +  +++DNLL RMEQYANNLEGLV +RTQ+Y  EK++ E+LL+ +LP ++A  LI G  V AES++ VTIYFSDI GFT+LS++STPMQV+TLLN+LY  FD + ++  VYKVETIGDAYMVVSGLP+R    H   IA MSL+ L ++  F I H+P +QLK+RIGMH+G V AGVVG KMPRYCLFGDTVNT+SRMESNG PLKIHVS+ +   L     F L  RG+V++KGKG+Q TYWL G K+
Sbjct:  700 NTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1227          

Query:  292 KVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSY-RYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIA-------NLIRIREN-ARITIICAKSSNYVRDIMLAAHHLKL-TNGEYVYFNIDLSANQIKGLQPWYMPNDSK-KNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNY------DYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXX--XRKKMKTELESMDWKINWCDIETQEKR 1695
            KV P  D+A++ V  E  +  N + ++ Y DS  S A+GP +A++       + ++G    + LA V R S Y +  +PI+T  G    L DK+ Y ++TR++  YK +      +F T+ W  K +  +            EC      +M   +    K +E+        E    N + A       N +R   N A + I+CA S + VR+IMLAAH L + T+GEYV+ NID+S       QPW   ND+  + N  AKEA+R++ T+S R+ D   Y +F ++VKE++   YNY      DY++   N+ +  F+DAV+LY +ALN+T+       +G  + + +W  +F GITG + ID NG  ++DYSLLD+D +   F+ V  + G +  L       + W   K   P D P+CG+D  KCP   P  V +L    + I++++ + IF   R K++ EL +M WKI W +++ +E +
Sbjct:   69 KVKPLADLALERVYRE-GILPNNSVNLIYRDSKLSDAIGPNVAVEQLLRKQIDCIIGYAYGYALAPVARMSPYWKNGIPIITPIGLTMSLDDKREYQLMTRINSPYKVVSSAVSTLFNTYKW--KRHIFMFHHAKAPSVAVGECFL----LMASLQHPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCA-SPDTVREIMLAAHDLGMATSGEYVFINIDVSTGS-HAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEM---NNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539          

Query: 1957 STQMFAKTAIYKENIVALKHLRLEGR---RIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHD--SFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKI--ENPPFRPRL------EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            +TQ++ KTAI+K  +VA+K L ++ +   R++++R  L ++K +KDL ++HI RF G C+D  + C++TEYCPKGSL+D+LENE+I+LD + + SL+ D+ +G+ +L  S I  HG LKSSNC+VDSRFVLK+TDFGL       EI+  +     +YK  LWTAPE+LR+   PP+G  K D+YSFAI+  E+++R GVF + + D+   +IV    + +  +  P RP +      E +  +N  ++S++ +CW EDP+ RP  + ++  +R +N   +  +++DNLL RMEQYANNLEGLV +RTQ+Y  EK++ E+LL+ +LP ++A  LI G  V AES++ VTIYFSDI GFT+LS++STPMQV+TLLN+LY  FD + ++  VYKVETIGDAYMVVSGLP+R    H   IA MSL+ L ++  F I H+P +QLK+RIGMH+G V AGVVG KMPRYCLFGDTVNT+SRMESNG PLKIHVS+ +   L     F L  RG+V++KGKG+Q TYWL G K+
Sbjct:  679 NTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1206          

Query:  238 IKIAVLLPNDSKSQCQ------LIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYK-VPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAY--------ECNFQTRPIMDIF---KTNGYKFLELSD-EIHMLTEHGFMN--STIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKL-TNGEYVYFNIDLSANQIKGLQPWYMPNDSK-KNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNY------DYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXX--XRKKMKTELESMDWKINWCDIETQEKR 1695
            I I V LP +   + +      L K  P  DVA+  V + R +    +  +++ +S  S AVGP   I+ + +   + ++G    + LA V R S +  + VP+ T      +L D+  +P+LTR+ G+YK + ++  +I   F W         ++++++   A         EC F    I ++    KT+ +     S+ E   L     ++  S ++NLI         I+CA S + VR+IMLAAH L + T+GEYV+ NID+S       QPW   ND+  + N  AKEA+R++ T+S R+ D   Y +F ++VKE++   YNY      DY++   N+ +  F+DAV+LY +ALN+T+       +G  + + +W  +F GITG + ID NG  ++DYSLLD+D +   F+ V  + G +  L       + W   K   P D P+CG+D  KCP   P  V +L    + I++++ + IF   R K++ EL +M WKI W +++ +E +
Sbjct:   28 IDIVVGLPIEEGDRGKNPFLLTLAKSKPVFDVALQDVYHLR-ILPYGSLKVTFENSALSDAVGPQKMIEHYCNKTVDAIMGLPYVYALAPVARISKFWGQGVPVFTTTALVDELGDRNEFPLLTRMMGSYKSLGKLVTRIAERFEWQH-------YFFMFNDEVARGPRNKGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRLQYRALLSEASVMSNLI---------ILCA-SPDTVREIMLAAHDLGMATSGEYVFINIDVSTGS-HAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEM---NNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518          

Query: 1957 STQMFAKTAIYKENIVALKHLRLEGR---RIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHD--SFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKI--ENPPFRPRL------EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            +TQ++ KTAI+K  +VA+K L ++ +   R++++R  L ++K +KDL ++HI RF G C+D  + C++TEYCPKGSL+D+LENE+I+LD + + SL+ D+ +G+ +L  S I  HG LKSSNC+VDSRFVLK+TDFGL       EI+  +     +YK  LWTAPE+LR+   PP+G  K D+YSFAI+  E+++R GVF + + D+   +IV    + +  +  P RP +      E +  +N  ++S++ +CW EDP+ RP  + ++  +R +N   +  +++DNLL RMEQYANNLEGLV +RTQ+Y  EK++ E+LL+ +LP ++A  LI G  V AES++ VTIYFSDI GFT+LS++STPMQV+TLLN+LY  FD + ++  VYKVETIGDAYMVVSGLP+R    H   IA MSL+ L ++  F I H+P +QLK+RIGMH+G V AGVVG KMPRYCLFGDTVNT+SRMESNG PLKIHVS+ +   L     F L  RG+V++KGKG+Q TYWL G K+
Sbjct:  738 NTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1265          

Query:  286 LIKVLPAIDVAIDHVKNERNL---FRNATF--SISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSS-YRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNW-------SPKSYTTVVFWY---------IWHKFDAYE-------CNFQTRPIMDIF----KTNGYKFLELSDEIHMLTEHGFMNSTIANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKL-TNGEYVYFNIDLSANQIKGLQPWYMPNDSK-KNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNY------DYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCP--PITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKR 1695
            L K +P ID+A+  V   + L   + N T+  S  Y D   +     +  I  + ++  + +LG  +++ LA V + ++     +PILT  G  S L+ KK YP LTR+ G+Y+ +     ++ A  +        S  +Y  ++F+Y         +  + ++ E       C F    I   F    KT   ++   + +     +      T    +R I   + + I+CA S + VR+IMLAAH L + T+GEYV+ NID+S       QPW   ND+  + N  AKEA+R++ T+S R+ D   Y +F ++VKE++   YNY      DY++   N+ +  F+DAV+LY +ALN+T+       +G  + + +W  +F GITG + ID NG  ++DYSLLD+D +   F+ V  + G +  L       + W   K   P D P+CG+D  KCP  P+  + + + S ++I +++ + +  + R K++ EL +M WKI W +++ +E +
Sbjct:   61 LQKAMPVIDIAVQEVIKAKKLPPGWINLTYWDSRLYEDILLAERHATVGVIQAYCEHRLDAILGFADNYGLATVTKVTAGLNGGIPILTTSGMPSLLNSKKEYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCA-SPDTVREIMLAAHDLGMATSGEYVFINIDVSTGS-HAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEM---NNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPGYPLHVY-LLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564          

Query: 1957 STQMFAKTAIYKENIVALKHLRLEGR---RIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHD--SFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKI--ENPPFRPRL------EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPL-------KIHVSESSKRELDTFGEFILTERGNVDIKGKGI 3465
            +TQ++ KTAI+K  +VA+K L ++ +   R++++R  L ++K +KDL ++HI RF G C+D  + C++TEYCPKGSL+D+LENE+I+LD + + SL+ D+ +G+ +L  S I  HG LKSSNC+VDSRFVLK+TDFGL       EI+  +     +YK  LWTAPE+LR+   PP+G  K D+YSFAI+  E+++R GVF + + D+   +IV    + +  +  P RP +      E +  +N  ++S++ +CW EDP+ RP  + ++  +R +N   +  +++DNLL RMEQYANNLEGLV +RTQ+Y  EK++ E+LL+ +LP ++A  LI G  V AES++ VTIYFSDI GFT+LS++STPMQV+TLLN+LY  FD + ++  VYKVETIGDAYMVVSGLP+R    H   IA MSL+ L ++  F I H+P +QLK+RIGMH+G V AGVVG KMPRYCLFGDTVNT+SRMESNG  +       KI+  +  K +++   +F+  E+ +++ +GK +
Sbjct:  111 NTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIEL--DFLKNEKESIEFEGKKM 632          

Query: 1993 ENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNK--LWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGI--NKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIV 3507
            E +VA KH      R  ++ +    ++S+++L+ +++ RFIG+CLD      +  +C +GS+ DV+    I++D+ F  SL++DM  G+++L  S +GYHG L S  CL+D R+ +KI+++GL   R         S + Y+ K  LW+APE+LR   +   G  + DVYS  I+C E+I R GVF + D      +I+    +     P RP LE +  I  N  ++ ++R C+ E P+ RP    ++ +LR +N + + +++D++   +E YA++LE  V++RT++  EEK++++ LLY MLPK+VA +L  G+ V  E+FE+VTI+FSD+  FT L+++ TP+QV+ LLN+LYT+FD I E HDVYKVETIGD Y+ VSGLP RNG  HVR IA MSLAFLS +  F++PH P +++ +RIGM+ G V AGVVG+ MPR+CLFGD VNTASRMESNGKP KIHVS  + R L   G F    RG V IKGKG+ +T+WL G     V
Sbjct:  586 EPVVAKKH----AYRPRLDDDKCTFMRSLRNLDQDNLNRFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLR---------SPEMYEKKDLLWSAPELLRAEDIK--GSKEGDVYSLGIICAELITRKGVFNMEDRKEDPEEIIYLLKKGGLKSP-RPDLEYDHTIEINPALLHLVRDCFTERPSERPSIETVRSQLRGMNSSRNDNLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQGTGAV 1079          

Query:  304 AIDVAIDHVKNERNLFRN--ATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGP-VNDFLLANVVRYSSYRYKVPILTAQGY--ASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSS-NYVRDIMLAAHHLKLTNGEYVYFNIDLSANQI------KGLQP-WYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQ---HYTDF---IIKVKEKSKSFYNYDYKIDD---ANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNM-IWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTL---VMARDRNIDWANEKNSA-PLDTPVCGFDGKKCP 1536
            A  +A+D +K E NL       F+I + D   S A G  + +D+   +  +V++GP +N   LA  +  S+Y +  PI+ A G   A+ L D + +P    LS   + +      +   + WS       V+ Y   + D  +C      +  +    G   L  S ++  ++  G + +    L +I+   RI + C K      R  +LAA    +   EYVY   D+ +          G +P W +   S +N+  A +AF+  I +           +YT F   II   +++  F   D + ++   A +  G+ HDAV  Y +AL+K L   +          M  +  SF G++G + I++ G       LL +D+   N   + T Y +N +     +  D  + WA+ KN+A P+D P+CGF G  CP
Sbjct:   60 AASIAVDRLKRE-NLMSGWEFNFTIEFDDCVESEAAG--MTVDLIEKHNVDVIIGPTMNQPTLAAFI-VSNY-FNRPII-AWGLVNAAQLDDFERFPNAGILSAGQRSLGVAIRAVLKRYEWS-----QFVYAYFTEE-DTEKCVTMRNDLQQVVSYFGDIILAYSIQVADISNDGMIEA----LKKIQSRGRIIVTCMKDGIGLRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSDENDTRALKAFKQSIFICDMMGQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENFTVAATYAGQLHDAVYAYGVALDKMLKAGQIAQYRNATAFMRYFPQSFIGMSGNVTINEKGTRNPTLFLLALDE-NNNNTRMATIYVENMSATFNALYSDEGVMWASRKNNARPVDVPLCGFTGNLCP 480          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQST-IGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGR-----EISNHDSFQFYKNKLWTAPEVLR-NPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENP-----PFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            Q+F    +++++ VA+K + ++  +  + R ++ ++K +KDL ++H+ +F G CLD     ++TEYCPKGSLQD+LENEQ +LD +FRLSLM D+ RGM +L S+ I  HGNLKSSNC+VDSRFVLKITDFGL   R  R     +  N +S  ++   LWTAPE+LR     PP G  K DVY+F I+  EI  R G FY+           +  + K  NP     PFRP LE       DI  IIR CW EDP  RP F  +K  +RR N   + G+I+DNLL RME YANNLE LV +RTQ Y+EEK++ E LLY +LP+SVA QLI G+PV AE+F++VTIYFSDI GFTA+SAESTPMQV+  LN+LYT FDSI E+ DVYKVETIGDAYMVVSGLP RNG  H R IA ++LA L  ++ F+I H+P+ +LK+RIG+HTG   AGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIH+SE++K  LD FG F+ T RG V +KGKG   TYWL G
Sbjct:  609 QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130          

Query:  235 EIKIAVLLPN---DSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISY--SDSNSSLAVGPLIAIDMFND-NVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGT-YKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSD-----EIHMLTEHGFMNSTI--ANLIRIREN----ARITIICAKSSNYVRDIMLAAHHLKLTN-GEYVYFNIDL-SANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSC-VGRFHDAVVLYCLALNKTLS-----LNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCP--PITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIETQEKRQR--RRSLNSANKKSASIPIF 1752
            ++    LLP+   D+K+ C + KVLP +++AI HV+        + F I     D+  S   GP+   +++      N + G   +++LA + RY+   ++VP+LT  G A + + K + Y  LTRL G    ++  V   I  +FNW+  +        I+   +A              K N   FL L+      E H + + GF  ST   A++ R+ +N    +RI I+CA   + +R IML A  L + + GEYV+ NI+L S  Q    QPWY  ND+  NN  A++A+ +++TV+ +QP+D  YT    ++K  +   YNY +  ++  S  V  F D V+LY  ALN+++      L R I   + V+ M WN SF GITG + ID NG   + YSLLDM+  TG F +V  F   +  L    ++ I WA ++  AP D P+CG+DG  CP   +  + +  + +  + +V+ +      R  + + E+ SM WK++  D+  ++  +R  R S +S  K+S+ + + 
Sbjct:   85 QLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQ-RMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADV-WQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTAL-------IYQNENAK------------VKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQS-IRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRM-WNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFL--HNRLEFEANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLM 597          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQST-IGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGR-----EISNHDSFQFYKNKLWTAPEVLR-NPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENP-----PFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            Q+F    +++++ VA+K + ++  +  + R ++ ++K +KDL ++H+ +F G CLD     ++TEYCPKGSLQD+LENEQ +LD +FRLSLM D+ RGM +L S+ I  HGNLKSSNC+VDSRFVLKITDFGL   R  R     +  N +S  ++   LWTAPE+LR     PP G  K DVY+F I+  EI  R G FY+           +  + K  NP     PFRP LE       DI  IIR CW EDP  RP F  +K  +RR N   + G+I+DNLL RME YANNLE LV +RTQ Y+EEK++ E LLY +LP+SVA QLI G+PV AE+F++VTIYFSDI GFTA+SAESTPMQV+  LN+LYT FDSI E+ DVYKVETIGDAYMVVSGLP RNG  H R IA ++LA L  ++ F+I H+P+ +LK+RIG+HTG   AGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIH+SE++K  LD FG F+ T RG V +KGKG   TYWL G
Sbjct:  609 QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130          

Query:  235 EIKIAVLLPN---DSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISY--SDSNSSLAVGPLIAIDMFND-NVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGT-YKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSD-----EIHMLTEHGFMNSTI--ANLIRIREN----ARITIICAKSSNYVRDIMLAAHHLKLTN-GEYVYFNIDL-SANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSC-VGRFHDAVVLYCLALNKTLS-----LNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCP--PITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIETQEKRQR--RRSLNSANKKSASIPIF 1752
            ++    LLP+   D+K+ C + KVLP +++AI HV+        + F I     D+  S   GP+   +++      N + G   +++LA + RY+   ++VP+LT  G A + + K + Y  LTRL G    ++  V   I  +FNW+  +        I+   +A              K N   FL L+      E H + + GF  ST   A++ R+ +N    +RI I+CA   + +R IML A  L + + GEYV+ NI+L S  Q    QPWY  ND+  NN  A++A+ +++TV+ +QP+D  YT    ++K  +   YNY +  ++  S  V  F D V+LY  ALN+++      L R I   + V+ M WN SF GITG + ID NG   + YSLLDM+  TG F +V  F   +  L    ++ I WA ++  AP D P+CG+DG  CP   +  + +  + +  + +V+ +      R  + + E+ SM WK++  D+  ++  +R  R S +S  K+S+ + + 
Sbjct:   85 QLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQ-RMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADV-WQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTAL-------IYQNENAK------------VKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQS-IRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRM-WNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFL--HNRLEFEANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLM 597          

Query:  514 YKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLI-RIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSA-------NQIKGLQPWYMPNDSKKNNVMAKEAFRSVI---TVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYK------IDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITG-KIIIDDNGAGFADYSLL-------DMDQITGNFLVVGTFYGKNKTLV--------MARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNK----LWTAPEVLR-NPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            + +P+++      D S+K  +P   R       + +    +   FNW     T V F Y+      Y+   +T  I+      G    ++    + +  HGFM++    L+ +   N RI +I      +V  ++       L+ G+Y    ID+           ++GL    +  D +   V A +++  ++   +VSF       + + + K  E+    +N+         +   ++     +DAV LY  AL + L       +G  +   I  S +    G  + ID+NG    +Y++L         +Q       VGTF  +N +L         +     IDW     + P   P CGF G+KC   T  + A ++   + ++ ++S+V++   + + EL+S+ WKI++ +++  E  + ++S          +P                        +  P    P I  S                    ++L+    +    T +F    +YK  + A+K +R   + ++I RE+  ++K ++D  +++I  FIG C DP N CII+EYC +GSL+D+LENE +KLD++F  S++ D+ RG++YL  S I +HG L +SNCLVDSR+V+K+TDFGL AF+ G E S+ D  Q    K    L+ APE+LR  P+   +G  + D YSF I+  E+  R G F  + +  +     V + +   NP +RP L+        +   +R CW E P  RP F  I+ KLR +      +I DN++  ME+YANNLE LV  RT Q  EEK++ + LL+ MLP+ VA QL +G  V  E +E+V+IYFSDI GFTA+SAE TP+QV+  LN+LYT FDSI   +DVYKVETIGDAYMVVSGLP RNG +H   IA MSL  LS + +FKI H+P  +L +RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMES+G PLKIH S   ++ LD  G +   ERG + +KGKG Q+TYWL G  E
Sbjct:  134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNW-----TQVSFLYLDDASGQYQPVAET--ILSTLTDAGVSIRDIRT-WNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGL----LLEDVEPLAVQAFQSYLGIVPTASVSFAT-----FANEVNKYMERPP--FNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVG--GTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP-----------------------RRLPPQSTHPLIRTSQ-------------------VSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVR--KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTD-MQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNP-YRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1100          

Query:  514 YKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLI-RIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSA-------NQIKGLQPWYMPNDSKKNNVMAKEAFRSVI---TVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYK------IDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITG-KIIIDDNGAGFADYSLL-------DMDQITGNFLVVGTFYGKNKTLV----------MARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNK----LWTAPEVLR-NPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            + +P+++      D S+K  +P   R       + +    +   FNW     T V F Y+      Y+   +T  I+      G    ++    + +  HGFM++    L+ +   N RI +I      +V  ++       L+ G+Y    ID+           ++GL    +  D +   V A +++  ++   +VSF       + + + K  E+    +N+         +   ++     +DAV LY  AL + L       +G  +   I  S +    G  + ID+NG    +Y++L         +Q       VGTF  +N +L           +     IDW     + P   P CGF G+KC   T  + A ++   + ++ ++S+V++   + + EL+S+ WKI++ +++  E  + ++S          +P                        +  P    P I  S                    ++L+    +    T +F    +YK  + A+K +R   + ++I RE+  ++K ++D  +++I  FIG C DP N CII+EYC +GSL+D+LENE +KLD++F  S++ D+ RG++YL  S I +HG L +SNCLVDSR+V+K+TDFGL AF+ G E S+ D  Q    K    L+ APE+LR  P+   +G  + D YSF I+  E+  R G F  + +  +     V + +   NP +RP L+        +   +R CW E P  RP F  I+ KLR +      +I DN++  ME+YANNLE LV  RT Q  EEK++ + LL+ MLP+ VA QL +G  V  E +E+V+IYFSDI GFTA+SAE TP+QV+  LN+LYT FDSI   +DVYKVETIGDAYMVVSGLP RNG +H   IA MSL  LS + +FKI H+P  +L +RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMES+G PLKIH S   ++ LD  G +   ERG + +KGKG Q+TYWL G  E
Sbjct:  134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNW-----TQVSFLYLDDASGQYQPVAET--ILSTLTDAGVSIRDIRT-WNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGL----LLEDVEPLAVQAFQSYLGIVPTASVSFAT-----FANEVNKYMERPP--FNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVG--GTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP-----------------------RRLPPQSTHPLIRTSQ-------------------VSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVR--KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTD-MQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNP-YRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1102          

Query:  514 YKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLI-RIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSA-------NQIKGLQPWYMPNDSKKNNVMAKEAFRSVI---TVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYK------IDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITG-KIIIDDNGAGFADYSLL-------DMDQITGNFLVVGTFYGKNKTLVMARD--------RNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNK----LWTAPEVLR-NPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            + +P+++      D S+K  +P   R       + +    +   FNW     T V F Y+      Y+   +T  I+      G    ++    + +  HGFM++    L+ +   N RI +I      +V  ++       L+ G+Y    ID+           ++GL    +  D +   V A +++  ++   +VSF       + + + K  E+    +N+         +   ++     +DAV LY  AL + L       +G  +   I  S +    G  + ID+NG    +Y++L         +Q       VGTF  +N +L               IDW     + P   P CGF G+KC   T  + A ++   + ++ ++S+V++   + + EL+S+ WKI++ +++  E     R   S  +  ++ P+   +Q++ S N   + +Y                                                    T +F    +YK  + A+K +R   + ++I RE+  ++K ++D  +++I  FIG C DP N CII+EYC +GSL+D+LENE +KLD++F  S++ D+ RG++YL  S I +HG L +SNCLVDSR+V+K+TDFGL AF+ G E S+ D  Q    K    L+ APE+LR  P+   +G  + D YSF I+  E+  R G F  + +  +     V + +   NP +RP L+        +   +R CW E P  RP F  I+ KLR +      +I DN++  ME+YANNLE LV  RT Q  EEK++ + LL+ MLP+ VA QL +G  V  E +E+V+IYFSDI GFTA+SAE TP+QV+  LN+LYT FDSI   +DVYKVETIGDAYMVVSGLP RNG +H   IA MSL  LS + +FKI H+P  +L +RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMES+G PLKIH S   ++ LD  G +   ERG + +KGKG Q+TYWL G  E
Sbjct:  134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNW-----TQVSFLYLDDASGQYQPVAET--ILSTLTDAGVSIRDIRT-WNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGL----LLEDVEPLAVQAFQSYLGIVPTASVSFAT-----FANEVNKYMERPP--FNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVG--GTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENE---REQQSQKQTRSTHPLIRTSQVSLSSNPDADFRY----------------------------------------------------TTIFTPIGLYKGQLYAIKKVR--KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTD-MQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNP-YRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1087          

Query:  100 SLSALMLSIFIVFLITLYLCSLCQAGKSYITRIIKPLDKSNESSLEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNAT-----FSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWH--KFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENI 3504
            SL  +   +FIV L  + +   C+A K  IT                 +AV+LP + K      +VLPAI +A + ++ +  L R  T     FS   S  + S     +IA+D    +  +  +GP   + +A+V R++S+ +K+P++TA G A      + +  + R   T K +      +   FNWS ++        I+H  K D     F +  I  + +      L    E      +  M      +  I++N RI  IC     + + + L    +K +  +Y  F +D+ A  + G    PW   +D + N+ +  + F+SV  V++++PD   YT F  ++ +++   +N   +    +   G FHD  VLY  AL++ L+   S  DG  +   + N    G+TG + ID   A F D+SL  M  + +G + +VG + G +K ++ +    I W   K   PLD P CGF   K   +    +  +   +  I+  IS  +  RK K++ EL  M W+I W +++ +       S N  +K++ S                     +   S+ G + +   I+    Y                               Q+FAKT  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM YL  S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E  N DS   Y  KLWTAPE+L     PP G  K DVYSF I+ QEI  R+G FY+  +D+   +I+       + P FRP  ++ R   +++  ++  CW EDP  RP F+ IK+ + + N          LL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L ++  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMES G+ L+IH+S ++K  LD FG F L  RG+V++KGKG  +TYWL G K ++
Sbjct:    8 SLLKMGYRVFIVLLTRMVVLE-CRAEKGNIT-----------------VAVMLPENLKYSWASPRVLPAIRMAQEKIQ-KSGLLRGHTINLLNFSTEDSSGSCSENEAQIIAVDTKLYHKPDAFIGPGCTYSVASVGRFASH-WKLPLITAGGPAYGFDKWEEFKTIVRTGPTTKKLGDFVNYLHGQFNWSSRALM------IFHDLKQDDRPHYFLSEGIYTVLREENITVLAFPYEDEQTYNYKDM------ITFIKDNGRIVYICGPLPTFFQIMKLFEDEVK-SPEDYAIFYLDVFAESLSGDVPMPW-QGSDIQWNDPI--KLFQSVFVVTYQEPDSPEYTAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQWP--KGCPPLDYPPCGFSPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFE-------SPNKYHKRAGS---------------------RLTLSQRG-SSYGSLITAHGKY-------------------------------QLFAKTGYFKGNLVAIKHVN--KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE--NEDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMDLSPKEIIQKVRNG-QKPYFRPTTDNSRHC-EELTILMEGCWSEDPAERPDFSHIKVFIAKFNK--QHQYSQYLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGEKTDV 1048          

Query:  238 IKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNAT-----FSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWH--KFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENI 3504
            I +AV+LP + K      +VLPAI +A + ++ +  L R  T     FS   S  + S     +IA+D    +  +  +GP   + +A+V R++S+ +K+P++TA G A      + +  + R   T K +      +   FNWS ++        I+H  K D     F +  I  + +      L    E      +  M      +  I++N RI  IC     + + + L    +K +  +Y  F +D+ A  + G    PW   +D + N+ +  + F+SV  V++++PD   YT F  ++ +++   +N   +    +   G FHD  VLY  AL++ L+   S  DG  +   + N    G+TG + ID   A F D+SL  M  + +G + +VG + G +K ++ +    I W   K   PLD P CGF   K   +    +  +   +  I+  IS  +  RK K++ EL  M W+I W +++ +       S N  +K++ S                     +   S+ G + +   I+    Y                               Q+FAKT  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM YL  S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E  N DS   Y  KLWTAPE+L     PP G  K DVYSF I+ QEI  R+G FY+  +D+   +I+       + P FRP  ++ R   +++  ++  CW EDP  RP F+ IK+ + + N          LL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L ++  FKI H+P+ QL++RI          ++  K    CLF   V + +        L+IH+S ++K  LD FG F L  RG+V++KGKG  +TYWL G K ++
Sbjct:   24 ITVAVMLPENLKYSWASPRVLPAIRMAQEKIQ-KSGLLRGHTINLLNFSTEDSSGSCSENEAQIIAVDTKLYHKPDAFIGPGCTYSVASVGRFASH-WKLPLITAGGPAYGFDKWEEFKTIVRTGPTTKKLGDFVNYLHGQFNWSSRALM------IFHDLKQDDRPHYFLSEGIYTVLREENITVLAFPYEDEQTYNYKDM------ITFIKDNGRIVYICGPLPTFFQIMKLFEDEVK-SPEDYAIFYLDVFAESLSGDVPMPW-QGSDIQWNDPI--KLFQSVFVVTYQEPDSPEYTAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQWP--KGCPPLDYPPCGFSPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFE-------SPNKYHKRAGS---------------------RLTLSQRG-SSYGSLITAHGKY-------------------------------QLFAKTGYFKGNLVAIKHVN--KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE--NEDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMDLSPKEIIQKVRNG-QKPYFRPTTDNSRHC-EELTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYS--QYLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRI---GIHTGTIIIISKFLMNCLFVMVVFSTA--------LRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGEKTDV 1025          

Query: 1921 LTLAGIQLSQLAST----QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            L+L G     L +T    Q+FAKT  +K NIVA+K++    RR+E+ R++LF++K ++D+ N H+ RFIG C+DP N CI+TEYCP+GSLQ++LEN+ I LD +F+ SL+ D+ +GM +L  S I  HGNLKSSNC+VD+RFVLKITD+GLS+ R   E    D+  +Y  KLW APE+ R    PP G  K DVYSF I+ QE+  R GVFY+    +   +IV       E P  RP L + +  ++++  +++ CW E+P+ RP F+ I + LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT+LSAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+PD+QLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNT+SRMESNG+PLKIHVS +++  L  F  F L  RG+V++KGKG  +TYWL G
Sbjct:  290 LSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINR--RRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRT--ESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLLSPKEIVDRVALG-EWPYLRPSL-NPQAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLG 811          

Query:  871 TIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL--QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDA--NSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGK----KCPPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNS 1719
              +C  S +  R +++  H   L   EYV+F ID+  +  +    QPW   +    ++V AKEAF+SV  +++ +P +Q Y DF+  +K  +K  +N+   +DD+  N   G F+D ++LYC ALN++LS +     GE V   +WN ++ G+TG + ID+NG    D++L DM  I TG+F +V  + G  K + +     I W   K   P+D P CGF  +    +   I    +  + + +I I++    V   RK K++ EL +  W+I+W DI+     +  RS  S
Sbjct:    2 VFVCC-SPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGD---SDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNF--TVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGK--VPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGS 286          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  L+   + Q++AKT  YK NI A+K++    +RIE+ R++LF++K ++D+ N H+ RFIG C+DP N CI+TEYCP+GSLQD++E+E I LD +FR SL+ D+ +GM +L  S I  HGNLKSSNC+VDSRFVLKITD+GL +F   ++ +  D   FY  +LWTAPE+LR    P  G  K DVYSF I+ QE+    GVFY+    +   +I+   V     P  RP L  +   ++++  ++  CW ED N RP F+QIK+ LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y+EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPM+V+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  ++ F+I H+P+ QL++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVSE+++  L  F  F L  RG+V++KGKG  +TYWL G
Sbjct:  547 GSLLTMDGNFQIYAKTGYYKGNITAIKYVN--KKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFH--KDSNLDDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEG-RWPYLRPLLCPQSH-SEEMGQLMLRCWSEDVNERPDFSQIKVLLRKNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLG 1060          

Query:  217 SNESSLEIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTR-PIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQ--EKRQRR 1704
            ++ S   I +AV+LP ++++      +V PA+  A++ V ++ NL       + ++ S +     S +V PL+A+D+         +GP  D+  + V R++++ ++VP++T+   A   +   +Y  +T +  T+K +     ++   F W   +    +  +  +K D   C F    P   + + N    +   D +    E       +  L  I   AR+  +C K   + R +M+          EY +F IDL    ++    +PW    D+  N   AKEAF+SV  +++R+P +  Y DF+ K+K ++   +N++ +    N   G FHD V+LY  ALN T+  + S   G+ V   +WN +++G+TG + +D+NG    D++L DM D  TG++ +V  + G  K +++     + W   K   P D P CGF  D   C    +T   +  + +  I I++V   V   RK K++ EL +  W+++W DI+    EK  RR
Sbjct:   40 AHASQKNITLAVILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGPGCDYSSSPVARFTTH-WEVPMITSGARALGFN---LYSSITNIGPTHKKLGEFVLRMHRHFGWDKHA----MLMFNDNKNDDRPCYFAVEGPYTQMREDN----ITADDLVFNEDEEPLRYDEL--LRDISHKARVVYVCCKWETF-RKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWAR-GDADDN--AAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWL--KGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRR 532          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  L+   + Q++AKT  YK NI A+K++    +RIE+ R++LF++K ++D+ N H+ RFIG C+DP N CI+TEYCP+GSLQD++E+E I LD +FR SL+ D+ +GM +L  S I  HGNLKSSNC+VDSRFVLKITD+GL +F   ++ +  D   FY  +LWTAPE+LR    P  G  K DVYSF I+ QE+    GVFY+    +   +I+   V     P  RP L  +   ++++  ++  CW ED N RP F+QIK+ LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y+EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPM+V+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  ++ F+I H+P+ QL++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVSE+++  L  F  F L  RG+V++KGKG  +TYWL G
Sbjct:  547 GSLLTMDGNFQIYAKTGYYKGNITAIKYVN--KKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFH--KDSNLDDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEG-RWPYLRPLLCPQSH-SEEMGQLMLRCWSEDVNERPDFSQIKVLLRKNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLG 1060          

Query:  217 SNESSLEIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTR-PIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQ--EKRQRR 1704
            ++ S   I +AV+LP ++++      +V PA+  A++ V ++ NL       + ++ S +     S +V PL+A+D+         +GP  D+  + V R++++ ++VP++T+   A   +   +Y  +T +  T+K +     ++   F W   +    +  +  +K D   C F    P   + + N    +   D +    E       +  L  I   AR+  +C K   + R +M+          EY +F IDL    ++    +PW    D+  N   AKEAF+SV  +++R+P +  Y DF+ K+K ++   +N++ +    N   G FHD V+LY  ALN T+  + S   G+ V   +WN +++G+TG + +D+NG    D++L DM D  TG++ +V  + G  K +++     + W   K   P D P CGF  D   C    +T   +  + +  I I++V   V   RK K++ EL +  W+++W DI+    EK  RR
Sbjct:   40 AHASQKNITLAVILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGPGCDYSSSPVARFTTH-WEVPMITSGARALGFN---LYSSITNIGPTHKKLGEFVLRMHRHFGWDKHA----MLMFNDNKNDDRPCYFAVEGPYTQMREDN----ITADDLVFNEDEEPLRYDEL--LRDISHKARVVYVCCKWETF-RKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWAR-GDADDN--AAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWL--KGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRR 532          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLE-----DERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGK 3459
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RF+G C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L +S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E    D++  Y  KLWTAPE+LR    P  G  K DVYSF I+ QEI  R+G FYI  +D+   +IV     K+ N   P FRP ++     +E GI  D       CW E+P  RP F QIK  + + N  G   ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S ++K  LD F  F L  RG++++K K
Sbjct:   54 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEAD--DAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQ----KVRNGQRPYFRPTVDISCHSEELGILMD------RCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLE-----DERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGK 3459
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RF+G C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L +S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E    D++  Y  KLWTAPE+LR    P  G  K DVYSF I+ QEI  R+G FYI  +D+   +IV     K+ N   P FRP ++     +E GI  D       CW E+P  RP F QIK  + + N  G   ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S ++K  LD F  F L  RG++++K K
Sbjct:  139 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEAD--DAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQ----KVRNGQRPYFRPTVDISCHSEELGILMD------RCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLE-----DERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGK 3459
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RF+G C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L +S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E    D++  Y  KLWTAPE+LR    P  G  K DVYSF I+ QEI  R+G FYI  +D+   +IV     K+ N   P FRP ++     +E GI  D       CW E+P  RP F QIK  + + N  G   ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S ++K  LD F  F L  RG++++K K
Sbjct:  184 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEAD--DAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQ----KVRNGQRPYFRPTVDISCHSEELGILMD------RCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLE-----DERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGK 3459
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RF+G C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L +S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E    D++  Y  KLWTAPE+LR    P  G  K DVYSF I+ QEI  R+G FYI  +D+   +IV     K+ N   P FRP ++     +E GI  D       CW E+P  RP F QIK  + + N  G   ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S ++K  LD F  F L  RG++++K K
Sbjct:  212 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEAD--DAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQ----KVRNGQRPYFRPTVDISCHSEELGILMD------RCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLE-----DERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGK 3459
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RF+G C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L +S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E    D++  Y  KLWTAPE+LR    P  G  K DVYSF I+ QEI  R+G FYI  +D+   +IV     K+ N   P FRP ++     +E GI  D       CW E+P  RP F QIK  + + N  G   ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S ++K  LD F  F L  RG++++K K
Sbjct:  107 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEAD--DAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQ----KVRNGQRPYFRPTVDISCHSEELGILMD------RCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSFAI+ QEI  RSG FY+  +D+   +IV     K+ N   P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  101 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE--PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQ----KVRNGQRPYFRPSI-DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 608          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSFAI+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD--DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 1042          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  D   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ +++P+LTA   AS  + K + Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    ++G+TG +++D N     D+ L  M  + +G+F     + G  K  +    R I W   K + PLD P C F  D   C   P++   +  L   V  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG--RALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYAREPGGPEQATHF----IRANGRIVYICG-PLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTK 3495
            G  L+     Q+FAKTA YK N+VA+K  R+  +RIE+ R++LF++K ++D+ N H+ RF+G C DP N CI+TEYCP+GSLQD+LENE I LD +FR SL  D+ +GML+L    IG HGNLKSSNC+VD RFVLKITD+GL +FR       H     +  KLWTAPE+LR  + P  G    DVYSF I+ QEI  RSGVFY+  +D+   +I+     + E PPFRP ++ +  + +++  +++ CW EDP  RP F QI+L LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD++ ++ DVYKVETIGDAYMVVSGLP RNG +H R +A M+LA L  +  F+I H+P +QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S  +K  L+ F  F L  RG+V++KGKG  +TYWL G +
Sbjct:  537 GSLLTTEGQFQVFAKTAYYKGNLVAVK--RVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGH---TLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVT-RGEQPPFRPSMDLQSHL-EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051          

Query:  235 EIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAV-----GPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNF-------QTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQ------PWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFD 1521
            ++ +AV+LP  ++       +V PA+++A+  VK   +L    T  +    S ++  V      PL A+D+  ++   V LGP   +  A V R++++ ++VP+LTA   A  +  K  Y + TR   ++  +      +     W  ++    +  Y     D   C F       + R  ++I   N  +F+E  D  H              L+R ++   R+  IC+ S +  R++ML A    LT  +YV+F++D+    ++G Q      PW   +   +    A++AF++   +++++PD+  Y +F+ ++K  +   +N+  +    N     FHD ++LY  A+ +TL+   ++TDGE +   +WN SF G+TG + ID NG    D+SL DMD  TG F VV  F G ++ L+   +  + W       P D P CGFD
Sbjct:   30 DLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAH-WRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA----LVLYADRLGDDRPCFFIVEGLYMRVRERLNI-TVNHQEFVE-GDPDHY-----------TKLLRTVQRKGRVIYICS-SPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRR---ARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWP--LGYPPPDIPKCGFD 454          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTG 3264
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSFAI+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD--DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  D   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ +++P+LTA   AS  + K + Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    ++G+TG +++D N     D+ L  M  + +G+F     + G  K  +    R I W   K + PLD P C F  D   C   P++   +  L   V  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG--RALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYAREPGGPEQATHF----IRANGRIVYICGPL-EMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query: 1966 MFAKTAIYKENIVALKHLRLEG----RRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKL-WTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRS--GVFYXXXXXXXXXXXXXXXXXKIENP----PFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
             FA   +Y+ N VAL ++  E     ++  + RE+        +L + +I  F G+C +P N CI+T+YC KGSLQDV+ N   ++D +F+LS   D+  G+L+L  S +  HGNLK SNCLVDS   LK++ FGL  F+ G    +++      ++L WTAPE+LR    P  G  + DVYSFAI+ +++I++   G F              + + +I++P    P RP L +++G  + I++++R CW E P LRP F  IK  LR  +  G   ILD+++ ++E YAN+LE +V +RT++   EKR+ E LL +MLP  V  QLI G+ V  E FE VTI+FSDI GFT L + S+P+QV+ LLN+LY+LFD   + HDVYKVETIGDAYMV SGLP RNG  H   IA M+L  LS    F+I H P+++LK+RIG+HTG V AGVVG+ MPRYCLFGDTVN ASRMES+  PL+IHVS+S+   L   G + L +RG + +KGKG Q T+WL G
Sbjct:  570 FFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMC----ELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPF------EDLEAAPEEIISRIKDPRAPVPLRPSLLEDKGDGR-IVALVRECWDESPELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKG 1078          

Query:  121 SIFIVFLITLYLCSLCQAGKSYITRIIKPLDKSNESSLEIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDE---IHMLTEHGFMNSTIANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQI--KGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAI--YKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENI 3504
            S+F+VF  T +L + C+                 E    I + V+LP N  K      +V PAI +A D ++ +  L R  T ++    + S     S +   ++A+D       +   GP   + +A+V R+ ++ +K+P++TA   A     K+ Y  + R   +   +      + + FNW+ +++              ++     RP    F + G  FL L  E   +  +      NS    +I  ++ N RI  IC     ++ + M    +  L   +Y  F +D+ A  I  K  +PW     S  N     + F+SV  ++ ++PD+  Y  F  ++  ++K  ++   +    +   G F+D  +LY  ALN+TL+   S  DG  +   + N  F G+TG +  D N     D++L  M +  TG + +V  + G NK +V +    I W   K S PLD P C F  D   C    +    +  +   +  I+  IS  +  RK K++ EL  M W+I W +++ +       S N  +K + S                     +   S+ G + +   I+    Y+               L    G     L + +   K  I   ++ +  LKH+R                    D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L  S IG HGNLKSSNC+VDSRFVLKITD+GL++FR   E  N DS   Y  KLWTAPE+L     PP G  K DVYSF I+ QEI  R+G FY+  +D+   +IV       + P FRP   D    ++++  ++  CW EDP  RP F+ IK+ + ++N  G   IL+NLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVS    RNG +H R IA MSLA L ++  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIH+S ++K  LD FG F L  RG+V++KGKG  +TYWL G K ++
Sbjct:    6 SLFVVF--TCFLMARCRT----------------EIGKNITVVVMLPDNHLKYSFAFPRVFPAIRMAHDDIQKKGKLLRGYTINLLNHSTESQGAGCSESQAQIMAVDTKLYEKPDAFFGPGCVYSVASVGRFVNH-WKLPLITAWAPAFGFDSKEEYRTIVRTGLSTTKLGEFAHYLHSHFNWTTRAFMLF-----------HDLKVDDRPYY--FISEGV-FLVLRRENITVEAVPYDDQKNSDYREMISSLKSNGRIVYICGPLDTFL-EFMRIFQNEGLPPEDYAIFYLDMFAKSILDKDYKPW---ESSDINWTDPIKLFKSVFVITAKEPDNPEYKAFQRELHARAKQEFSVQLEPSLEDIIAGCFYDGFMLYAQALNETLAEGGSQNDGINITQKMQNRRFWGVTGLVSTDKNNDRDIDFNLWAMTNHKTGQYGIVAYYNGTNKEIVWSETEKIQWP--KGSPPLDNPPCVFSMDEPFCNEDQLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFE-------SPNKYHKCAGS---------------------RLTISQRG-SSYGSLITAHGKYQ---------------LFAKTGYFKGNLVAIKHVNKKRIELTRQVLFELKHMR--------------------DVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE--NEDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVDGMDLSPKEIVQKVRNG-QKPYFRPT-TDTSCHSEELSILMEGCWAEDPADRPDFSYIKIFVMKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSDSQSRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWLLGEKTDV 1047          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSFAI+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD--DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  D   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ + +P+LTA   AS  + K + Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    ++G+TG +++D N     D+ L  M  + +G+F     + G  K  +    R I W   K + PLD P C F  D   C   P++   +  L   +  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG--RALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WHLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYTREPGGPEQATHF----IRANGRIVYICG-PLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSFAI+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD--DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 1042          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  D   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ +++P+LTA   AS  + K + Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    ++G+TG +++D N     D+ L  M  + +G+F     + G  K  +    R I W   K + PLD P C F  D   C   P++   +  L   V  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAVEALG--RALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYAREPGGPEQATHF----IRANGRIVYICG-PLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTK 3495
            G  L+     Q+FAKTA YK N+VA+K  R+  +RIE+ R++LF++K ++D+ N H+ RF+G C DP N CI+TEYCP+GSLQD+LENE I LD +FR SL  D+ +GML+L    IG HGNLKSSNC+VD RFVLKITD+GL +FR       H     +  KLWTAPE+LR  + P  G    DVYSF I+ QEI  RSGVFY+  +D+   +I+     + E PPFRP ++ +  + +++  +++ CW EDP  RP F QI+L LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD++ ++ DVYKVETIGDAYMVVSGLP RNG +H R +A M+LA L  +  F+I H+P +QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ L+IH+S  +K  L+ F  F L  RG+V++KGKG  +TYWL G +
Sbjct:  537 GSLLTTEGQFQVFAKTAYYKGNLVAVK--RVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGH---TLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVT-RGEQPPFRPSMDLQSHL-EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051          

Query:  235 EIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAV-----GPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNF-------QTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQ------PWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFD 1521
            ++ +AV+LP  ++       +V PA+++A+  VK   +L    T  +    S ++  V      PL A+D+  ++   V LGP   +  A V R++++ ++VP+LTA   A  +  K  Y + TR   ++  +      +     W  ++    +  Y     D   C F       + R  ++I   N  +F+E  D  H              L+R ++   R+  IC+ S +  R++ML A    LT  +YV+F++D+    ++G Q      PW   +   +    A++AF++   +++++PD+  Y +F+ ++K  +   +N+  +    N     FHD ++LY  A+ +TL+   ++TDGE +   +WN SF G+TG + ID NG    D+SL DMD  TG F VV  F G ++ L+   +  + W       P D P CGFD
Sbjct:   30 DLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAH-WRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA----LVLYADRLGDDRPCFFIVEGLYMRVRERLNI-TVNHQEFVE-GDPDHY-----------TKLLRTVQRKGRVIYICS-SPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRR---ARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWP--LGYPPPDIPKCGFD 454          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            Q+FA T  +K N+VA+KH+    +RIE+ R++LF++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LEN+ I LD +FR SL+ D+ +GM +L  S I  HG+LKSSNC+VDSRFVLKITD+GL++FR   E    DS   Y  KLWTAPE+L    LP  G+ KADVYSF I+ QEI  RSG FY+  +D+   +IV       + P FRP + D   +N++++ ++  CW +DP  RP F QIK  +RR N  G   ILDNLL RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG  H   IA M+LA L  +  F+I H+P  QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD  G F L  RG+V++KGKG  +TYWL G ++ 
Sbjct:  535 QIFANTGHFKGNVVAIKHV--NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIASHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE--PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNG-QRPYFRPSI-DRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042          

Query:  238 IKIAVLLPNDSKSQC-QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDK-KIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGL------QPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRKKM-KTELESMDWKINWCDIE 1680
            + +AV+LP  + S      +V PA+ +A++ +   R L  +  F  S  D   S  + PL A+D+   +  ++LLGP   +  A+V R++S+ +++P+LTA   AS  S K + Y  L R   +   +      +   FNW+ ++       Y+  + D     F    + +  + +    L +  +++     G   +T      IR N RI  IC      + +I+L A    LTNG+YV+F +D+    ++        +PW   N +++     +EAF++V+ +++R+P +  Y +F  ++  +++  +  +      N   G F+D ++LY   LN+T+    +  DG  +   +    + G+TG +++D N     D+ L  M D ++G+F     + G  K  +    R I W   K   PLD P C F  D   C   P++   +  L   +  I+  +S  +  RK M + EL SM W+I W +++
Sbjct:   25 LTLAVVLPEHNLSYAWAWPRVGPAVALAMEALG--RALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFSAKSEHYRTLVRTGPSAPKLGEFVVMLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSN---LSVQHQVYAREPGGPEQATHF----IRANGRIVYICG-PLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRSMGRPW-QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYRGVTGLVVMDKNNDRETDFVLWAMGDLVSGDFQPAAHYSGAEKQ-IWWTGRPIPWV--KGVPPLDNPPCAFDMDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500          

Query:  286 LIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSY-RYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTE--------HGFMNSTI-ANLIRI-RENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLN--RSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCP---PITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEK---------------------------RQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLN---PKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQF--YKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDE-----RGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRIN-GAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVD 3510
            L +VLP +D+AI+ V    +L    + S+  +DS    +V P++ + +    + +++LGP   F LA V RY+    Y+ PILT  G AS L DK  Y  L R+  ++  +E++   +F  FNW P+   T++F       +  + + + +   D       + L    E H + E        +   N+   + + R+ R+  R+ ++CA   + VR+IM+ A  L   NGEYV+FNIDL +++   LQPW   ND+ + N  A  A+R+++T++ R+P    Y +F  +VK  +KS YN+ Y  ++ NS VG FHDAV+LY LA+N T+  +    I +G  +   + N +F GITG + I+ NG   ADYSLLDMD+ T NF+VV  +YG  +   +   + IDW NE N  P D P CGFD   C            V+ +V+I ++ V+  VI+ + ++++EL +M+W+I W ++E  E+                           R  +    S  K++ S+ I   N  N+   S  N    K+Q         E    +S                     + T+AG+ LSQ+  TQ+F KTA YK  +VALK L L  +RIE+  ++L ++K VKDL ++++ RFIG CLD  NEC+++EYCPKGSLQDVLEN+ + LD +F+ SLM D+CRGM+YL    G HGNLKSSNCLVDSRF LKI DFGL + R  ++  + +  ++  Y+NKLWTAPE+LRNPT PP G  + DVYSFAI+CQEIIYR GVF+ISD D   P  +V++V++I N  +RP L+ E     +  ++ +I+ +R+CWQEDP  RP F  IK ++ R N  A  G+ILDNLL RMEQY+NNLE LVA+RT  Y EEK++AE+LLY MLPKSVA  L+RGE VTAE F+ VTIYFSDICGFTALS+ESTP++V+TLLN+LYTLFD I E +D YKVETIGDAYMVVSGLP RNGI+H R I+ M+L+FL  IY FKI HKPD QLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+S  +   L+  G F+ T RG V++KGKG Q TYWLHG  ++IVD
Sbjct:    3 LEQVLPVVDIAIETVTT-LDLLHGHSVSLIANDSKCDYSVAPVLGVLLLQQKI-DLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDKAEYFNLIRVGPSFDGVEKMLYLVFQRFNWKPRDVQTILF------IELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQYEMHNAQFKSEIFRVMRDEIRLVVLCA-DPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVS---------------------VDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVD 1101          

Query:  232 LEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVF----------WYIWHKFDAYECNFQTRPIMDIFKTNGYKFLE--LSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPI----TPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREI-SNHDSFQFYKNKLWTAPEVLRN--PTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGD-ILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLP 3519
            L +++  L P++        +VLPAID+A++ +++    F   +F+        +LA   L  +   N N  NV+ GP+NDF LAN  R+S+  Y VPI+   G+A  LSDK  Y MLTR+  TY D+E VF      + W P   T +              + H        FQ   +        YK L   L DE  +         T   L R+ ++ARI I+C      VRDIML AH L + NG+Y +FN+DL ++Q K  +PWY    S + N  A++A+R+++TV+  +PD   Y  F  +V+ ++   Y++ Y+  +    +G FHDAV LY LALN  L+   +IT+G  +   +WN +F G+TG + ID NG   ADYSLLDM+ +TG+F VV  ++G +K+L     R IDW N  N  PL TP CGFDG +C          + AV+ I+++T+ LV+ ++ + R K + EL +M+W I W  ++  EK  RR                                Y+ ++    PN+       S+  RK  SE                   +  A++QMFA+TA Y ++IVALK LR + R +E ++ +  ++K VKDLN +HI R IG+CL+  ++CI+ EYCPKGSLQDVLENEQIKLD +F+ SLMQD+CRG++YL    G HGNLKSSNCLVDSRFVLKITDFGL   R    + S   SF F++N LWTAPE+L +   T+ P    K DVYSFAIVCQEI+YR GVFYI +     PD +V  V+    PPFRP L+   G ++D++ +I   W +DP++RP F  IKL +R++N AGD + +LDNLL+RMEQYANNLE LV QRT QY EEK++ EDLLYSMLP+SVA QL R +PVTAESFE VTIYFSDI GFT+LSAESTPMQV+ LLN LYTLFD I E+ D YKVETIGDAYMV SGLPQRNG  H R +A MS+AFL  I++F+IPH+P+++L++RIG+H+G VCAGVVG KMPRYCLFGDTVNT+SRMESNG PLKIH+S+ +   L TF  FI+TERG V++KGKG QKTYWLHG    IVD +P
Sbjct:   81 LGVQLGPLGPDN------FAQVLPAIDLALEDIQS-FPAFGGVSFTTVLILYIDALACDALALLTQLNSNGVNVIFGPLNDFTLANAARFSTAMYNVPIVAPAGFAHQLSDKLEYGMLTRVLFTYSDLEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHT--GMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDV---------TDRFLKRLPDSARIIILCT-DPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEYRTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKHLRR--------------------------------YRRESDIRSPNQ------SSDPLRKISSETCT----------------AAAANSQMFARTAFYMKSIVALKPLRRQTR-MEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLESEVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKPPFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIP 1122          

Query:  460 GPVNDFLLANVVRYSSYR-YKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYI------WHK-FDAYECNFQT--RPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLN--RSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPP-ITPWXXXXXXXXXXXXXXXXXXXXXXRKKMK--TELESMDWKINWCDIETQEK-RQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHD--SFQFYKNKLWTAPEVLRNP-TLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKI--ENPPFRPRLEDERGINKD------IISIIRSCWQEDPNLRPGFAQIKLKLRRIN-GAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVD 3510
            GP   F LA V RY+ Y  Y+ PI+T+ G A++L DK+ Y  L R+     D+E +   IF  +NW P+    ++  Y+       HK  D     F    R  ++   ++ ++++ L  + +  T   F +     +   RE  R+ ++CA   + VR+IM+ AH L   NGEYV+FNIDL +++    +PWY   DS + N  A  A+R+++T++ R+P+   Y DF  KVK  +K  Y+++Y  ++ NS VG FHDAV+LY LA+N TL+ +    I++G  + + + + +F GITG + I+ NG   ADYSLLDMD+ T NF VV  +YG  K   +   + IDW ++ N  P D P CGFD  +C   ++   +  + ++++ I ++  ++  I +K++  +EL +M+W+I W ++E  E+   RRRS+ S + +    P     Q   +  ++     +A+     PNE      Q +       + S    S+ S+ T+AG+ LSQ+   Q+FAKTA YK N+VALK + L  +R+E+N +IL +IK VKDL +++I RFIG CLD  NEC++TEYCPKGSLQD+LEN+ + LD +F+ SLM D+CRGM+YL  + G HGNLKSSNCLVDSRF LKI DFGL + R  +E+   D   +  Y+NKLWTAPE+LRNP T P  G  + DVYSF I+ QEIIYR GVFYISD D   P  +++++R+     PPFRP L  E  ++ D      ++ I+RSCW EDPN RP F  +K ++ R N  A  G+ILDNLL RMEQY+NNLE LVA+RT QY EEK++AE+LLY MLPK VA  L++GE VTAE F+ VTIYFSDICGFTALS+ESTPM+V+ LLN+LYTLFD I E +D YKVETIGDAYMVVSGLP RNG +H R IA MSL+FL  I+ FKI HKPD QLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+S  +   L+  G F+ TERG V++KGKG+QKTYWLHG  +NIVD
Sbjct:   37 GPFCTFCLAAVARYNRYYLYQKPIITS-GAAANLEDKEEYYNLIRVGPMNFDIENMLLAIFQRYNWLPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYI-LRVKPYSATNKHFQSEVFRCM---REEVRLVVLCA-DPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGVIYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNE----QQQQDEDPAIAPKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQEL-VDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVD 1070          

Query:  274 SQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYR-YKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFW----YIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRS--ITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPP-ITPWXXXXXXXXXXXXXXXXXXXXXXRKKMK--TELESMDWKINWCDIETQEK-RQRRRSL-----------NSANKKSASIPI----------FIHNQLNDSRNSYLNPKYQAKAS---KEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIG----REISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERG-INKD----IISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPT 3522
            S   L +VLP +DVA+   ++   L  N T  +  +DS    ++ P++ + M  +   +++LGP   F L  V RY+ Y  Y+ PI+T+ G AS L++K  Y  L R+  +++ +E +  KIF  +NW P+   TV+       I  +    E       +M +          +S     LT           L ++ E  RI ++CA   + VRDIM+ A  L   NGEYV+FNIDL +++   ++PW   ND+ + N  A  A+RS++T++ R+P+   Y +F  +VKE +   YN+ Y  ++ NS VG FHDAV+LY LA+N TL  + S  I +G  V   + + SF GITG + I+ NG   ADYSLLDMD+ TG F VV  + G  K   + +DR IDW NE+N  P D P CGFD   C   +T   +  + ++++ I  +  ++  I +K++  +EL  M+W+I W ++E  E+   RRRSL            +  KK A +            F  N     R++  +P   A  +   +      +           S S V   S S  S+ T+AG+ LSQ+ + Q+FAKTA YK  +VALK L L  +RIE+   +L ++K VKDL ++++ RFIG CLDP NEC++TEYCPKGSLQD+LEN+ + LD +F+LSLM D+CRGM+YL  + G HGNLKSSNC+VDSRF LKI DFGL + R      R+  + D +  Y+NKLWTAPE+LR P  P  G  + DVYSFAI+CQE+IYR GVF++SD D I P  +V+RVR  +NPPFRP L +E   +  D    + +++  CW EDP  RP F   K ++ R N   + G+ILDNLL RMEQY+NNLE LVA+RT QY  EK++AEDLLY MLPK+VA  L+RGE VTAE F+ V+IYFSDICGFTALS+ESTP+QV+TLLN+LYTLFD I E +  YKVETIGDAYMVVSGLP+RNG  H   I+ M+L+FL+ IY F+I H P  QLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+S ++   L   G F+ T RG V++KGKG Q TYWLHG  + IVD  P 
Sbjct:    7 SHMSLERVLPVVDVAVASAQSV-GLLSNVTVRLLSNDSECDYSIAPVVGMLMLRE--VDLMLGPYCSFCLGAVARYNRYHLYQRPIITSGGGASVLNNKVEYYNLIRVGPSHEQIEEMLLKIFKHYNWRPRPVQTVLVVGPPDEINSRQHQSESIISDALVMSVAIEKMLTQPNVSYIARRLTYKPGRPHLATQLFKVLEEVRIVVLCA-DPDTVRDIMIRAEELGFINGEYVFFNIDLFSSEKLTVRPWRRVNDTAERNSKAFRAYRSLMTITLRKPNSPEYRNFSRQVKELAYHKYNFTYPEEEVNSFVGAFHDAVLLYALAINDTLREHGSEGIRNGSLVTEKMKSRSFEGITGTVSINKNGDRNADYSLLDMDKDTGEFAVVAHYNGNKKVYELVKDRQIDWNNEENLPPKDIPTCGFDYSLCKKDLTQMALYAVVVLLVLICFLTILIFVIYRKLRLESELHGMNWRIAWEELEPTERVAARRRSLAQPQPPPPQKQTTNKKKRARLNQKKQQQQQPHWFFANHHGTKRSNRGDPDEAAAETLPLRPSGGGANDSGGGDIGAGDSQSVVQMDSASMESVETIAGVPLSQIPTAQLFAKTAYYKGTLVALKQLNLRNKRIEVTNRLLMEVKRVKDLASDNVVRFIGACLDPPNECLVTEYCPKGSLQDILENDNLNLDWMFKLSLMADICRGMIYLHHSFGSHGNLKSSNCMVDSRFSLKIADFGLQSLRSNKLEYRDKEDGD-YSTYRNKLWTAPELLRLPNPPFEGTKEGDVYSFAIICQEVIYRKGVFFLSDSDFIEPQDIVERVRTPQNPPFRPALVEEMSDLEPDRTAALTAMVELCWHEDPGARPTFNAAKSRISRFNKTAESGNILDNLLKRMEQYSNNLESLVAKRTDQYQVEKKKAEDLLYCMLPKAVATTLMRGEAVTAEWFDSVSIYFSDICGFTALSSESTPLQVVTLLNDLYTLFDRIIEQYSCYKVETIGDAYMVVSGLPERNGNRHAGEISRMALSFLNNIYSFEIRHMPGVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISATTHELLTDIGNFVTTVRGEVEMKGKGKQLTYWLHGEGDKIVDPPPA 1129          

Query:  196 IIKPLDKSNESSLEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDH-VKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAY------ECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRE-NARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFY-NYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXX----XRKKMKTELESMDWKINWCDI-----ETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            ++  L  +N  ++++ I V+LP   K    L +  PAI+ AI+H + +  N+       I+Y DS  S   GPL AID++    A+V +GP  D+ +A + R+S  R+ +P+L+A    S  SDK  Y +LTR+ G+Y      F K+ A FN+            I+H F          C+F    I    ++  YK     D  +   +    N+  + L++    + R+ ++CA   + VR+IM+ AH L   NGEYV+FNIDL +++     PWY  +D+ + N  A+ A+ +++TV+ R+P    Y  F  +VK K+K  Y N+ Y  ++ NS VG FHDAV+LY  ALN+TL  N SI+DG  +   +WN +F GITG + ID NG   ADYSLLD++     F VV  ++G  K     + + I WA  +   P D PVCGFDG  CPP  P+    + I+V+  +LVI +V         K++ EL  M+W++ W DI     E   K +R+ S  S                       LN KY   +S  G                                T+A + L+   + Q+F KT  YK  IVA+K +  +   I I + +L +IK +KDL N+HI R  G C+DP + C +TEYCPKGSLQDVLEN+QIKLD +FR S+MQD+ RG+ YL  S I  HGNLKS+NC+VDSRFV+KITDFGL  FR   +    +S+ FY  KLWTAPE+LR  T  P G  K D+YSF+I+CQEI+YR+GVFY+ ++D+   +I V     +  P FRP L+D    + ++ +IIR CW EDP  RP    +K  +R++N  GD G+ILDNLL+RMEQYANNLE LV +RT  Y EEK++AE+LLY MLPK VAGQLIRGE V AE+F++VTIYFSDICGFTALSAESTPMQV+ LLN+LYT FDSI E+ DVYKVETIGDAYMVVSGLP RNG +H R I+ MSLA L  +  F+I H+PD+QLK+RIG+HTG V AGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+S  +K  LD FG F +  RG +D+KGKG Q TYWL G K++
Sbjct:    9 LVNALYINNIEAVDLHIGVILPFKGKFPWVLKRTKPAIEFAINHSIPSTFNVI------INYRDSECSDTEGPLAAIDLYVQKRAHVFIGPACDYAVAPIARFS-LRWGIPVLSAGALVSAFSDKSEYSLLTRVQGSYAKAGGCFVKLCADFNFRS-------IGLIYHDFRNRPNGINSNCHFTMEAIFLAVRS-AYK-----DPWYKSFDQTSKNNDFSALLQAASMHTRVVVLCAAPES-VREIMIKAHELNFDNGEYVFFNIDLFSSKNASQTPWYKADDTPERNEAARLAYDALMTVTLRKPTSPEYKTFSEEVKRKAKELYPNFTYGEEEVNSFVGAFHDAVILYATALNETLEANGSISDGAAITKRMWNRTFEGITGTVSIDANGDRNADYSLLDLNPENDKFEVVANYFGNKKQYEKVKGKEIHWAGGRTEPPPDVPVCGFDGSLCPPEEPFPEYGIVIIVLGSILVIVLVTVFFIYRHIKLEAELAEMNWRVKWDDILFGSPEKNHKLERQGSRIS-----------------------LNRKYSYASSCSGD-------------------------------TIA-VHLNDAGNRQLFTKTGYYKGAIVAVKPI--QRTNITITKPLLIEIKRMKDLQNDHIVRLSGACIDPPHCCTLTEYCPKGSLQDVLENDQIKLDWMFRYSIMQDILRGLSYLHTSEIRVHGNLKSTNCVVDSRFVVKITDFGLRYFREVEKEEEDESYAFYNKKLWTAPEILRISTKNPCGTQKGDIYSFSIICQEIVYRNGVFYLHNLDLSPKEIYVKVRNGLR-PYFRPTLDDYDCPSDELANIIRRCWAEDPAERPDCQALKSLIRKLNRDGDKGNILDNLLSRMEQYANNLEALVEERTADYLEEKKKAENLLYLMLPKPVAGQLIRGESVAAETFDQVTIYFSDICGFTALSAESTPMQVVNLLNDLYTTFDSIIENFDVYKVETIGDAYMVVSGLPVRNGNLHAREISRMSLALLDAVLSFRIKHRPDEQLKLRIGLHTGFVVAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSTQTKETLDNFGTFEVELRGQIDMKGKGTQTTYWLLGEKQS 1051          

Query:  109 ALMLSIFIVFLITLYLCSLCQAGKSYITRIIKPLDKSNE----SSLE-IKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWH--KFDAYECNFQTR-PIMDIFKTN-GYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPR----------------LEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTG 3264
             L+ S+++  L+ L       AG S     ++PL +       SSL  I +A++LP  +++      +V PA++ A++ V ++  L       + +S S +     S +V PL+A+D+   +     +GP  D+  + V R++++ ++VP++TA   A   +   +Y  +T    T+K +     ++   F W    Y  V+F    H  K D   C F    P  ++   N   K +  +++   L+    +N        I +  R+  +C K   + R +M+  +  +L   EYV+F IDL    ++    +PW        ++  AK+AF+SV  +++R+P +  Y  F+ K+K  +K  +N+  +    N   G FHD V+LY  ALN+++  +     G  V   +WN +F+G+TG + +D+NG    D++L DM D  +G + +V  +    K +V+     + W   K S P D PVCGF  D   C    +T   +  +    I I++V   V   RK K++ EL +  W++ W DI+         +L+ A +++ S                     +   S  G N  S                         LLTL G       + Q++AKT  YK NI A+K++    +RIE+ R++LF++K ++D+ N H+ RFIG C+D  N CI+TEYCP+GSLQD++E E I LD +FR SL+ D+ +GM +L  S I  HGNLKSSNCLVDSRFVLKITD+GL++FR  +E    D+  +Y  KLWTAPE++R+    P G  K DVYSF I+ QE+    GVFY                  +++PPF P+                L   +  ++++  +++ CW ED N RP F QIK+ L + N     +ILDNLL+RMEQYANNLE LV +RTQ Y+EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTA+SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H   IA MSLA L  +Y F+I H+PD QL++RIG+HTG
Sbjct:    7 GLLGSVWLPLLVLL-------AGVSLGVMELEPLSQEESHPAGSSLRNITLAIILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAHDPWAFIGPGCDYASSPVARFTTH-WEVPMVTAGAPALGFN---MYSSITNTGPTHKKLGEFVVRMHHNFGW--HKYAMVMF----HDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLSYADLING-------ISQRGRVVYVCCKWDTF-RKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPW---ARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEIVSVYNSSAKQMVLEPGMKVHWL--KGSPPPDIPVCGFKNDNPACLAKTVTMHQMISIVACFIFIIIVTVTVFIYRKVKLENELAAQLWRVYWEDIQIS-------NLDKALRRACS---------------------RLTLSLRGSNYGS-------------------------LLTLEG-------NVQIYAKTCYYKGNITAIKYVN--KKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYLEDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFY------------------LDSPPFSPKEIVEHVAEGRWPYLRPLLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTG 986          

Query:  238 IKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNAT----FSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQI--KGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVC--GFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAI--YKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIV 3507
            I +AV+LP++ K      +VLPAI +A +H+     L   A     FS+  S  + S     +IA+D    +  +  LGP   + +A+V R++S+ +K+P++TA G A    + + +  L R   T   +      + A FNW+ ++        I+H           RP    F + G     L++ + +       N++   ++  IRE+ RI  IC     +   +      +K T  +Y  F +D     +  +  QPW+      K+ +   + F++V  ++FR+PD+  Y  F  ++ +++   +N   +    +   G F+D  VLY  ALN+ L+   S  DG  +   + N S  G+TG +  D N A + D+SL  M  +T    V G + G NK +V ++ + I WA      P+D P C    +G+       W        V+     +S +   + K++ EL  M W+I W D++ +       S N  +K++ S                     +   S+ G + +   IS    ++               L    G     L + +   K  I   ++ +  LKH+R                    D+  NH+ RF+G C+DP N CI+TEYCP+GSLQ         +++    +L+     GM YL  S IG HGNLKSSNC+VDSRFVLKITD+GL++FR      N DS + Y  KLWTAPE+L     PP G  K D+YSF I+ QEI  R+G FY+  +D+   +I+       + P FRP  ++ R   +++  ++  CW EDP  RP F+ IK+ + ++N  G   IL+NLL+RMEQYANNLE LV +RTQ Y EEKRRAE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT+         V+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L ++  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMES G+ L+IH+S ++K  LD FG F L  RG+V++K K      WL   +E I+
Sbjct:   34 ITVAVMLPDNMKYPWASPRVLPAIRMAREHILRSGMLRDRAVHLLNFSVEDSAGSCSENKAQIIAVDTKLYHRPDAFLGPGCVYSVASVGRFASH-WKLPLITAGGLAYGFDNSEEFRTLVRTGPTTTKLGDFVNSLHAEFNWTRRALL------IFHDLKR-----DDRP--HFFLSEGIYINLLAENMTVEVLPYEDNTSYQEIVTFIRESGRIVYICGPLQTFFNIMSTFEEEVKNTE-DYAIFYLDAFGESLSNEAHQPWHTSAMQWKDPI---KLFQNVFVITFREPDNPEYAAFRTELHKRATQDFNVQLEPSLMDYIAGCFYDGFVLYATALNEALADGVSQNDGINITTRMLNRSIWGVTGLVSTDQNNARYTDFSLWSMSNLTTGQYVAGHYNGTNKEIVWSK-KGIQWA---KGIPIDDPRCLVSCEGRS------W--------VLLFFKGLSYIGNRKLKLEKELARMLWRIKWEDLQFE-------SPNKYHKRAGS---------------------RLTLSQRG-SSYGSLISAHGKHQ---------------LFAKTGYFKGNLVAIKHVNKKRIELTRQVLFELKHMR--------------------DVQFNHLTRFVGACIDPPNICIVTEYCPRGSLQ---------VNTYASCTLL-----GMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFR--SSYDNEDSHELYARKLWTAPELLIYDRPPPQGTQKGDIYSFGIILQEIALRNGPFYVEAMDLSPKEIIQKVRNG-QRPYFRPTTDNSRHC-EELTILMEGCWAEDPTERPDFSHIKIFITKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRRAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTS--------NVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFDLQLRGDVEMKVK------WLFLKEELIL 1003          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  L+   + Q+FAKTA +K NIVA+K++    +RIE+ R++LF++K ++D+ N+H+ RFIG C+DP N  I+TEYCP+GSLQD+LENE I LD +F+ SL+ D+ +GM +L  S I  HGNLKSSNC+VD+RFVLKITD+GLS+FR   E    D+  +Y  KLW AP++LR    P  G  K D+YSF I+ QE+  R GVFYI    +   +IV       E P  RP + + +  ++++  +++ CW E+P  RP F+ IK+ LR+ N     DILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT+LSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+PDQQLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNT+SRMESNG+PLKIHVS +S   L  F  F L  RG+V++KGKG  +TYWL G
Sbjct:  553 GSLLTADGNFQVFAKTAYFKGNIVAIKYVNR--KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT--ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGDSLSPKEIVDRVALG-EWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLG 1066          

Query:  238 IKIAVLLPNDSKS-QCQLIKVLPAIDVAIDHVKNERNLFRNATFSISY-----SDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKK-IYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQI--KGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDA--NSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNS 1719
            IK+AV+LP  + S      +V PAID A+  V +  +L    +    +     +D   S ++ PL+A+D+   +     +GP  D+  + V  ++++ + +P++TA   A   SD+   Y  +T    T+K +      I   F WS  +    +  +   K    EC F    +    K      ++L     +  E     +   +L +I+E  R+  +C  S +  R +M+      L   E+V+  ID+    +  + +QPW        ++ +AK+A++SV  +++R+P +  Y DF++ +K  +K  +N+   +DD+  N   G F+D ++LY  ALN++L+ +      + +   +WN ++ G+TG + ID +G    D++L DM D  +  F +V  + G  K +         W       P D P CGF  D   C    IT   +  + +  I +++    V   RK K++ EL +  W+I+W D++     +  RS  S
Sbjct:   49 IKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHA----LLMFGDSKMGERECYFAVEGLYTELKEVNITTVDL-----VFEEDSRPVNYSEHLQKIKEEGRVVFVCC-SPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPW---ARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNF--TVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMSNLEKVLRSAGS 541          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  L+   + Q+FAKTA +K NIVA+K++    +RIE+ R++LF++K ++D+ N+H+ RFIG C+DP N  I+TEYCP+GSLQD+LENE I LD +F+ SL+ D+ +GM +L  S I  HGNLKSSNC+VD+RFVLKITD+GLS+FR   E    D+  +Y  KLW AP++LR    P  G  K D+YSF I+ QE+  R GVFYI    +   +IV       E P  RP + + +  ++++  +++ CW E+P  RP F+ IK+ LR+ N     DILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT+LSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L  +  FKI H+PDQQLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNT+SRMESNG+PLKIHVS +S   L  F  F L  RG+V++KGKG  +TYWL G
Sbjct:  553 GSLLTADGNFQVFAKTAYFKGNIVAIKYVNR--KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT--ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGDSLSPKEIVDRVALG-EWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLG 1066          

Query:  238 IKIAVLLPNDSKS-QCQLIKVLPAIDVAIDHVKNERNLFRNATFSISY-----SDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKK-IYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQI--KGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDA--NSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNS 1719
            IK+AV+LP  + S      +V PAID A+  V +  +L    +    +     +D   S ++ PL+A+D+   +     +GP  D+  + V  ++++ + +P++TA   A   SD+   Y  +T    T+K +      I   F WS  +    +  +   K    EC F    +    K      ++L     +  E     +   +L +I+E  R+  +C  S +  R +M+      L   E+V+  ID+    +  + +QPW        ++ +AK+A++SV  +++R+P +  Y DF++ +K  +K  +N+   +DD+  N   G F+D ++LY  ALN++L+ +      + +   +WN ++ G+TG + ID +G    D++L DM D  +  F +V  + G  K +         W       P D P CGF  D   C    IT   +  + +  I +++    V   RK K++ EL +  W+I+W D++     +  RS  S
Sbjct:   49 IKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHA----LLMFGDSKMGERECYFAVEGLYTELKEVNITTVDL-----VFEEDSRPVNYSEHLQKIKEEGRVVFVCC-SPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPW---ARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNF--TVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMSNLEKVLRSAGS 541          

Query: 1918 LLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPR----------------LEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            LLTL G       + Q++AKT  YK NI A+K++    +RIE+ R++LF++K ++D+ N H+ RFIG C+D  N CI+TEYCP+GSLQD++E E I LD +FR SL+ D+ +GM +L  S I  HGNLKSSNCLVDSRFVLKITD+GL++FR  +E    D+  +Y  KLWTAPE++R+    P G  K DVYSF I+ QE+    GVFY                  +++PPF P+                L   +  ++++  +++ CW ED N RP F QIK+ L + N     +ILDNLL+RMEQYANNLE LV +RTQ Y+EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTA+SAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H   IA MSLA L  +Y F+I H+PD QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVSE+++  L  F  F L  RG++++KGKG  +TYWL G
Sbjct:  535 LLTLEG-------NVQIYAKTCYYKGNITAIKYV--NKKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYLEDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFY------------------LDSPPFSPKEIVEHVAEGRWPYLRPLLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLG 1046          

Query:  238 IKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWH--KFDAYECNFQTR-PIMDIFKTN-GYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKG--LQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM 1380
            I +A++LP  +++      +V PA++ A++ V ++  L       + +S S +     S +V PL+A+D+   +     +GP  D+  + V R++++ ++VP++TA   A   +   +Y  +T    T+K +     ++   F W    Y  V+F    H  K D   C F    P  ++   N   K +  +++   L+    +N        I +  R+  +C K   + R +M+  +  +L   EYV+F IDL    ++    +PW        ++  AK+AF+SV  +++R+P +  Y  F+ K+K  +K  +N+  +    N   G FHD V+LY  ALN+++  +     G  V   +WN +F+G+TG + +D+NG    D++L DM
Sbjct:   25 ITLAIILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAHDPWAFIGPGCDYASSPVARFTTH-WEVPMVTAGAPALGFN---MYSSITNTGPTHKKLGEFVVRMHHNFGW--HKYAMVMF----HDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLSYADLING-------ISQRGRVVYVCCKWDTF-RKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPW---ARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDM 396          

Query:  853 RENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNID-----LSANQI-KGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAI--YKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSL-QDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIEN---PPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKE 3498
            R+   +   C  ++ + R  M+ AH   +T G+YV+F +D     LS + + +  +PW   ++  +    AKEA+++V+ +S+R+P +  Y DF++K+K+++K  +N+  +    N   G F+DA+++Y  ALNKTLS    + DG  +   +WN ++ G+TG+  ID NG    D+SL D+ D  TG F VV ++ G +  L+      I W     S P D P+CGF+ + C     +   V ++   +I +++ +S  +  RK K++ EL SM W++ W +I+     + RRS  S                            +   S  G +  S   +Q  N                 +    G     L + +   K  I   +E +  LKH+R                    D+ N H+ RF+G C+DP N CI+TEYCP+GSL QD+LENE I LD VFR SL+ D+ +GML+L  S IG HG+LKSSNC+VDSRFVLKITD+GL++FR   E    D    Y  KLWTAPE+LR    PP G  K DVYS  I+ QEI  R+G FY             + V+K++N   P FRP   DE    +++  +++ CW EDP  RP F+QIK+ + + N     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT+LSAESTPMQV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG ++ + IA MSLA L  +  FKI H+ + +LK+RIG+HTG VCAGVVG+KMPR+CLFGDTVNTASRMESNG+ LKIHVS+++K  LD FG F L  RG+V++KGKG  +TYWL G  E
Sbjct:    1 RDCVSVVYFCCSAAVF-RQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPWKRGDEFDEQ---AKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPG--GSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARRSAGS----------------------------KLTLSMRGSSCGSLLTTQGRN----------------QMFAKTGYYRGNLVAIKPINKKKIELTREVLFELKHMR--------------------DVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSEC--EDMHSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFY----VEGMDLSPKEIVQKVKNGQRPYFRPS-TDESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNKENSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGEIE 822          

Query: 2032 RRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQST-IGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDG-------DILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            ++IE+ R++LF++K ++D+ N H+ RF+G C+D  N CIITEYCP+GSLQD+LENE I LD +FR SLM D+ +GMLYL S+ IG HGNLKSSNC+VDSRFVLKITD+GLS+ R   +  +  S  +++ +LWTAPE+LR   + P G  K DVYSFAI+ QEI  RSG FY+    + + +IV       E P  RP + D  G ++++  +++ CW E+   RP F QIK+ L++ +   DG        ILDNLL+RMEQYANNLE LV +RTQ Y EEK +AE LLY +LP SVA QL RGE V AE+F+ VTIY SDI GFTA+SA+STPMQV+  LN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP  NG  H   +A M+LA LS +  F I H+P Q+L +RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRME+ G+  +IH+S ++K  LD +G F++   G+VDIKGKG  +TYWL G
Sbjct:   13 KKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKADS--SANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEANHLTAKEIVQRVKLG-EWPYLRPTV-DPGGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLG 502          

Query: 1981 AIYKENIVALKHL-RLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGR-----EISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
             IY+ N VALK L R     ++ NR   F +K ++++ + ++  F G+C++  N CI+T+YC KGSL+DVL+    +LD +F+ S   D+  GM++L +S I  HGNLK S CL+DSR  +K+T FG+  FR G+     +I+N  SF  +    WTAPE+LR   LP  G  K DV+SFAI+ +E+IY         + +   DI+      I  PP RP L +       I ++IR CW E  + RP F+ +   LR  +  GD +ILDN+++++E+YAN+LE +V  RT Q   EK++ + LL S+LP  V  QL  G+ V  E +E VTI+F DI GFTA+SA STP++VI LLN+LY L D I +++DVYKVETIGDAYMV SGLP RNG+ HV  IA MSL FLS I  F+I H P +QLK+RIG+++G V AGVVG  MPRYCLFGDTVN ASRMES G PL IHVSE++   L   G + L ERG +++KGKG Q TYWL G
Sbjct:  215 GIYQGNQVALKFLERTHPPDLKSNR---FALK-MREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSF--FIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYVGIHLEPKDIIDQVRDGIAVPPLRPLLTER--CEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKG 716          

Query: 1198 FHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSS---FNGITGKIIIDDNGAGFADYSLLDMDQ---ITGNFLVVGTFYGKNKTLVMARD-RNIDWANEKNSAPLDTPVCGFDGKKC 1533
             HDA +LY +A+ + L    +  DG  V   I  S+   F G +G++ ID NG  F DY++ D+ +    TG   +    Y   +T+    + + + W + +   P D P CGF G+ C
Sbjct:    4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKMGWPDGR--PPSDMPECGFTGELC 120          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGR-----EISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            +MF    IY+ N VALK L+        ++ +L +++ +++L + ++  F G+C++  N CI+T+YC KGSL+DVL+    +LD +F+ S   D+  GM++L +S I  HGNLK S CL+DSR  +K+T FG+  FR G+     +++N D  + +    WT+PE+LR    P  G  K DV+SF ++ +E+IY         VD+   +I+        +PP RP L +       I ++I+ CW E P+ RP F  I   LR  +  G   ILDN+++++E+YAN+LE +V  RT Q   EK++ + LL S+LP  V  QL  G+ V  E FE+VTI+F DI GFTA+SA S+P++VITLLN+LY L D I +++DVYKVETIGDAYMV SGLP RNG+ HV  I+ MSL FLS I  F+I H P +QLKIRIG+++G V AGVVG  MPRYCLFGDTVN ASRMES G PL+IHVSES+   L + G + L ERG + +KGKG Q TYWL+G
Sbjct:  543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKKGKIMDVNNQDIAELF----WTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGVDMEPKEIIDQVREGKCSPPLRPLLTER--CEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHRSILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNG 1051          

Query:  244 IAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVAN----VLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFW-YIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITI-ICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEK--SKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSS---FNGITGKIIIDDNGAGFADYSLLDMDQITGN---FLVVGTFYGKNKTLVMARD-RNIDWANEKNSAPLDTPVCGFDGKKCPPI 1542
            I +  P    +   ++++  A+ +A D + +      N TF+ +Y+D     A    +++D F   V       LLGPV     + V    + ++ VP+L   G+   +    +Y    R+    + M ++ E     F W+  +          W   D    + +      +  T   K+      +H             NL+ I   ARI I IC   S   R+++L A  L L  G++++  +    +       ++    +++ +    +A   V+  + +      Y  F+ +V+ +     FY+      + +      HDA +LY +A+ + L    +  DG  +   I  S+   F G++G++ ID NG  F DY++ ++ Q  GN   FL V  F     ++    + + + W   +   P D P+CGF G+ C  I
Sbjct:   19 IGLQAPQALSNPFSVMRLGAALQIAFDSLNSNPTFMPNHTFAFTYADC----ACDAKVSLDSFVTQVREKGIIALLGPVCA-EASEVTGLLAAQWNVPMLGFVGHTQRMDSSAVYDTYVRIMSPLQRMGQMLEATMRHFGWTRAAMLGGTAQNSTWANIDELWASVERELARSVTITARIKYDTSDKVLHR-----------QNLLDISTKARIVILICG--SEEAREVLLEAQSLGLATGKFIFLVVQQFEDS------FWKSVAAERLDTQTLQALEPVMLFTIKAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPYAAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNL-QKKGNSSQFLPVMVFDTFQGSISFTPEYQKMVWP--EGGPPNDMPICGFLGELCQEI 439          

Query: 2053 EILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYL-QSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISN------HDSFQFYKNKL-WTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAG-DGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            EI   I  ++++ + ++  F G+C++  N CI+T+YC KGSL+DVL+    +LD +F+ S   D+  GM++L +S I  HGNLK S CL+DSR  +K+T FG+  FR G++          D++     +L WTAPE+LR   LP  G  K DV+SFAI+ +E   R          +  PDI+      I  PP RP L +       I ++IR CW E  + RP F+ +   LR  +  G   +ILDN+++++E+YAN+LE +V  RT Q   EK++ + LL S+LP  V  QL  G+ V  E +E VTI+F DI GFTA+SA STP++VI LLN+LY L D I +++DVYKVETIGDAYMV SGLP RNG+ HV  IA MSL FLS I  F+I H P +QLK+RIG+++G V AGVVG  MPRYCLFGDTVN ASRMES G PL IHVSE++   L   G + L ERG +++KGKG Q TYWL G
Sbjct:  142 EIPIGIYQMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLRMEDLPVNGTPKGDVFSFAILMRESTPREWPTATRANRVPFPDIIDQVRDGIAVPPLRPLLTER--CEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKG 627          

Query: 1957 STQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSA 2364
            S ++FA   + K +I + K            +++L +I+  K +++ +I +FI    D  N  I+ E CP GSL ++L+  ++  +   R    Q +C  + Y+ S    H +LK  N   DS + LKI DFGL+A
Sbjct:  103 SGEIFAAKTVAKASIKSEK----------TRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAA 227          

Query: 2077 VKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCR----GMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEI 2520
            +K+L++ +I  + G   + GN  I  EY P GS+  +L N        F  SL+ +  R    G+ YL      H ++K +N L+D +  +KITDFG+S          +       +  W +PEV++         AKAD++S   V  E+
Sbjct:  508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATT----AKADIWSTGCVVIEM 650          

Query: 2002 VALKHLRL--EGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNEC-IITEYCPKGSLQDVLENEQIKLDSVFRLS------LMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEII 2523
            VA+K + L  + R+  I  EIL     +KD  + +I  F+   L   ++  ++ E+   GSL D++EN     +S   L+      ++++ C+G+ +L      H ++KS N L+D+R  +KITDFG  A R+  + S   +        W APEV++          K DV+S  I+  E++
Sbjct:  591 VAIKQMVLSKQPRKELIVNEILV----MKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCA-RLTDKRSKRAT--MVGTPYWMAPEVVKQREYD----EKIDVWSLGIMTIEML 762          

Query: 1987 YKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFY 2544
            + + +VA+K +  E    E+N +I+ +I  +K+LN+N+I ++ G         I+ EYC  GSL+ ++      L      + +     G+ YL      H ++K++N L+ +   +K+ DFG+S       I N  +        W APE+L N     +    +D++S      E++ ++  ++
Sbjct:   46 HTDQVVAIKEVVYENDE-ELN-DIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVST------IVNSSALTLAGTLNWMAPEILGNRGASTL----SDIWSLGATVVEMLTKNPPYH 219          

Query: 1999 IVALKHLRLEGRRIEI---NREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQ---FYKNKLWTAPEVLRNPTLPPVGL---AKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQ-IKLKLRRINGAGDGDILDNLLTR 2787
            + A+K L L+    E+    REI F + S+K ++N  I R+ G  L   +  II E+C  GSL+ +L     K+D  +   +M+++   +  +      H ++K++N L+ +   +K+ DFG++A        N  S +         W APEV+        G+    K D++S  I   EI   +  +   +       I       I++ P  PRLED R  +  +   I  C  EDP  R      +K K  R + A    IL  L++R
Sbjct:   48 VYAIKVLNLDSDSDEVEDVQREIQF-LASLKQISN--ITRYYGSYLKDTSLWIIMEHCAGGSLRSLL--RPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQ------VNQTSLRRQTMAGTPYWMAPEVIME------GVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLI-------IKSKP--PRLED-RSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISR 293          

Query: 1963 QMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQST-IGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDS-FQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLED---ERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGT 3492
            Q+F    IYK N+VA+K  R+  R+IE+ REI +++K ++ + + ++  F G C++P N CI+ +YCPKGSLQD+LENE IKLDS+F  SL+ D+ +GM YL ST I  HG LKS NC+VD R+VLKITD+GL+ F+  ++IS  +  +  Y  KLWTAPE+LR     P G  K DVYSF I+ QE++ RSG F         P  ++++V ++E+PPFRP+L     E      I+ + + CW+E+P+ RP F +I+  +R++      +I+DN++  +E+YANNLE LV +RT Q  +EKR+ E+LL  MLP SVA  L+ G+ VTAE+F++V+I+FSDI GFT+LS+ESTP+QV+ LLN+LYTLFD I  ++DVYKVETIGDAYMVVSGLP RNG  H   IA M+L  L EI  FKI H+P+ +LK+RIG+H+G   AGVVG KMPRYCLFGDTVNTASRMESNG+ LKIH+S S+KR LD  G + + +RG V +KGKG   TYWL G+
Sbjct:    6 QIFTTVGIYKSNMVAIK--RINKRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRKLWTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPF-DLSYYTNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLPMGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGS 517          

Query: 2023 LEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRI--NGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEI-YKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGT 3492
            L  R I+I+R++L ++K ++D+ ++++ +FIG C+ P N CI+ +YC +GSLQD+LEN+ +KLD VF  SL+ D+ +GM YL  S I  HGNLKSSNCLVDSR+VLKITD+GL   R   + S  ++   +++ LW APE+LR P+ PP G  K DVYSF+I+ QE   R G +     + + P  ++++VRK E PP+RP + +     +++  +++ CW EDP+LRP F +IK  +RRI        +I DN++  ME YA+NLE LVAQRT Q  +EKR+ + LL S+LP+ VA QL +G+ V AESF +VTIYFSDI GFT+LSAESTPMQV+T LN+LYT+FD I +++DVYKVETIGDAYMV SGLP RNG  H   IA M+L  +  + + F + HKP+ +L++R+G HTG V AGVVG  M RYCLFGDTVNTASRMESNG+PL+IH+S+ +K  LD  G F++  RG V +KGKG  +T+WL  T
Sbjct:    8 LPKRTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIETN--WRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPY---SANYMEPKAIIEKVRKSEFPPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWLVST 496          

Query: 1951 LASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGR----EISNHDSFQFYKNKLWTAPEVLRN--PTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNG 3357
            LA    F + +  K  +VALK LR +   + + R++L ++K V+D+ + ++  +IG+C  P N CI+++YC +GSLQ++L N++I LD  FR S   D+  GM  +  S+I  HG+L+SS CL+DSR+V K+ DFGL+  +  +    EI  H     Y    W APE+L+N   T  PV     DVYSF I+  E++ R   +  ++   I     +       NPPFRP    E   N+ +  ++  CW +DP  RP F+ IK +LR + G G   I+DN+L  ME Y   LE +V +RT+Q  +EK + ++LLY MLP+ +A  L RGEPV AES+  VTI+FSDI GFT L+A STP+QV+ LLN+LYT FD+I + HDVYKVETIGDAYMVVSGLP RNG  H   IA M+L  LS +  F+  H P++ + +RIG+HTG   AGVVG+KMPRYCLFGDTVN ASRMES G
Sbjct:   53 LALFPWFCEHSFIKSYLVALKMLRKDS--LTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQ---YSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTEFAPIEVIERIRCHL---NPPFRPETPFEIR-NRSVTKLMTQCWNDDPQARPTFSDIKRQLRLLKG-GKSSIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTG 518          

Query: 2068 IKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVL---------RNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLED--ERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLP 3519
            +K V+DL++ ++ R++G+C++  N C+++ +C +G+LQD+L N+ IKLD +FR S   D+  GM  +  S I  HGNLKSSNCL+DSR+  KITD+GL   R  +   +   F  YKN  WTAPE+L         +N T         DVYS+ IV  EII R    Y ++ D +S   V++ VRK + P FRP+     E      ++ + + CW  D   RP F+ IK KL+  NG G+G I   + +R   Y NN   LV  R       KR    LL  +L + +A +L +G  V+AESF+ VTI+FSDI GFT+++A+STP+QV+ LLN LYT FD + ++HDVYKVETIGDAYMVVSGLP RNG  H   +A M+L  LSE+  F+IPH P +++++RIG+H+G   AGVVG+KMPRYCLFGDTVN ASRMES+G  L+IHVS   K  LD  G + L ERG V +KGKG   TY+L G K+     LP
Sbjct:    1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGEFAVYKNLFWTAPELLPLADGFKDRKNKT------QAGDVYSYGIVLYEIITRDEP-YSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLK-ANGMGNGKI-SGMFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTG-KDGFDKPLP 477          

Query: 2185 VLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVL---------RNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLED--ERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDG-DILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIK 3453
            +L N+ IKLD +FR S   D+  GM  +  S I  HGNLKSSNCL+DSR+  KITD+GL   R  +   +   F  Y+N  WT PE+L         +N T         DVYS+ IV  EII R    Y ++ D +S   V++ VRK + P FRP+     E      ++ + + CW  D   RP F+ IK KL+  NG G   +I+DN++T M +Y + LE +V +RT+Q  EEK + ++LLY MLP+ +A +L +G PV+AESF+ VTI+FSDI GFT+++A+STP+QV+ LLN LYT FD + ++HDVYKVETIGDAYMVVSGLP RNG  H   +A M+L  LSE+  F+IPH P +++++RIG+H+G   AGVVG+KMPRYCLFGDTVN ASRMES+G  L+IHVS   K  LD  G + L ERG V +K
Sbjct:    2 LLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGEFAVYRNLFWTVPELLPLADGFKDHKNKT------QAGDVYSYGIVLYEIITRDEP-YSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLK-ANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429          

Query:  238 IKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSI-SYSDSNSSL------AVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHM-LTEHGFMNST-IANLIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMK--TELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENI 3504
            I  AV+LP N  K    L +V PA+ +A + +  +  L    T +I +YS  N +       +   ++ +D    +  +V  GP   + LA+V R+ S+ +K+P++TA G A        Y  + R+  +   +      +   FNW+ ++   V+F         Y+     RP    F + G  F+ L DE++M ++   + N      L+  I+EN RI  IC     ++  + L    ++     Y  F +D+ A  +   +PW    ++K +     + F+SV  +++  PD+  Y DF  K+  +++  +  + +    +   G F+D  VLY +AL++TL+   +  +G  +     N SF G+TG + ID   A   D  L  M +Q TG + VV  + G  K +V ++   I W +     PLD P C F  D   C    P L  V     + +++       I +K+K   EL  M W++ W D++ +       S N  +K++ S                     +   S+ G + +   I+    Y                               Q+FAKT  +K N+VA+KH+    +RIE+ R++L ++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L  S  G HGNLKSSNC+VDSRFVLKITD+GL++FR   E  N DS   Y  KLWTAPE+L     PP G  K DVYSF I+ QEI  R+G FY+  +D+   +IV       + P FRP   D R  ++++  ++  CW EDP  RP F  IK+ + ++N  G   IL+NLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L ++  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD F  F L  RG+V++KGKG  +TYWL G K ++
Sbjct:   34 ITAAVMLPDNYHKYPWALPRVFPALLMAQEDLHTKHKLLLGHTITILNYSTENPAAPGSCAESRAQVVVVDAKLYSRPDVFFGPGCVYPLASVGRFVSH-WKLPLITAGGPAYGFEKLDEYKTIVRIGPSTTKLGAFVNVLHTQFNWTSRA--VVIF---------YDLKQDDRP--HYFLSEGI-FMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQDPE-SYAIFYLDVFAESLTHRKPW---QNAKFDWTNPIQVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPS--CGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQFE-------SPNKYHKRAGS---------------------RLTLSQRG-SSYGSLITAQGKY-------------------------------QLFAKTGYFKGNLVAIKHV--NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE--NDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMDLSPKEIVQKVRNG-QRPYFRPT-TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1052          

Query:  928 HLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRS---------VITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMK--TELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQ-STIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENI 3504
            H  L+ G  ++ N+    N     +P+    D K+     KE  RS         V  +++  PD+  Y DF  K+  +++  +  + +    +   G F+D  VLY +AL++TL+   +  +G  +     N SF G+TG + ID   A   D  L  M +Q TG + VV  + G  K +V ++   I W +     PLD P C F  D   C    P L  V     + +++       I +K+K   EL  M W++ W D++ +       S N  +K++ S                     +   S+ G + +   I+    Y                               Q+FAKT  +K N+VA+KH+    +RIE+ R++L ++K ++D+  NH+ RFIG C+DP N CI+TEYCP+GSLQD+LENE I LD +FR SL+ D+ +GM +L  S  G HGNLKSSNC+VDSRFVLKITD+GL++FR   E  N DS   Y  KLWTAPE+L     PP G  K DVYSF I+ QEI  R+G FY+  +D+   +IV       + P FRP   D R  ++++  ++  CW EDP  RP F  IK+ + ++N  G   IL+NLL+RMEQYANNLE LV +RTQ Y EEKR+AE+LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFT++SAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R IA MSLA L ++  FKI H+P+ QL++RIG+HTG VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ LKIHVS ++K  LD F  F L  RG+V++KGKG  +TYWL G K ++
Sbjct:  197 HYFLSEG--IFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPS--CGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQFE-------SPNKYHKRAGS---------------------RLTLSQRG-SSYGSLITAQGKY-------------------------------QLFAKTGYFKGNLVAIKHV--NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE--NDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMDLSPKEIVQKVRNG-QRPYFRPT-TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1000          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGY-HGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKEN 3501
            G  ++   + Q+FAKT  YK NIVA+K+     +RIE+NR++LF++K ++D+ N H+ RFIG C+DP N CIITEYCP+GSLQD+LEN+ I L+ +F+ SL+ D+ +GM++L +++ + HG LKSSNC+VD+RFVLKITD+GLS FR   ++ + DS  +Y  KLW APE+LR    PP G  K DVYSF+I+ QE+  R G FY+    +   +IV   +   + P  RP + D +  + ++  +++ CW E+P  RP F  I+L LR+ N     +ILDNLL+RMEQYANNLE LV +RTQ Y+EEKR+AE LLY +LP SVA QL RGE V AE+F+ V+IYFSDI GFTALSAESTPM+V+TLLN+LYT FD++ ++ DVYKVETIGDAYMVVSGLP RNG +H R IA M+LA L  +  F+I H+P+QQLK+RIG+H+G VCAGVVG+KMPRYCLFGDTVNT+SRMES+G+ LKIHVS +++  L  F  F L  RG++DIKGKG   TYWL G  ++
Sbjct:  544 GSLMTANGNLQVFAKTGYYKGNIVAIKYT--NKKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFRQESDVGS-DSHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDGDPLSPKEIVDRVILG-DWPCLRPSI-DPQSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRTNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESDS 1062          

Query:  238 IKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSS-----LAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDM-DQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIETQEKRQRRRS 1710
            I +A++LP  ++       ++ PA++ AI  + ++ NL  N   +  +  S +S      +V PL+A+D+         +GP   +  + V  ++++ + VP++TA   A    D  IYP +T    T+K + R   +I   F W  + Y T++F    +K D   C F    + +  K+     + L D +    +     S I  L  I+   R+  +C  S +  R +M+      L + +YV+  IDL A  +   QPW       +++ +AK+AF+SV  +S+R+P +Q Y  F+  +K  +K+ +NY  +    N   G F+D ++LY  ALN+T  +  +   G+ +   +WN +F+G+TG + +D +G    D++L D+ D  + +F +V  +    + +      ++ W     + PLD P CGF  D   C    IT   +  +++  I  + +   +   RK K++ EL +  W+I+W DI+     +  RS
Sbjct:   45 ITLAIILPETNTAYPWAWPRIGPALERAIIKINSDPNLLPNHHLTYVFKSSENSNGICSESVAPLVAVDLEFAYKPWAFIGPGCSYTASPVGLFTTH-WDVPLITAGAPAIAFLDG-IYPTITNTGPTHKKLGRFALRICEHFGW--REYVTLMFSD--NKEDDRPCYFAMEGLYEELKSIN---ISLQDSVFEENKPPINYSQI--LADIQNIGRVMFVCC-SPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPW---ARGDQDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRWLG--GARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQMSNLDKVLRS 530          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGY-HGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRL-----EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  ++   + Q++ KT  YK N+VA+K++    +RIE+ R +LF++K ++D++N H+ RFIG C+DP N CIITEYCP+GSLQD++E+E + LD +FR SL+ D+ +GM +L +++ + HGNLKSSNC+VDSRFVLKITD+GL + R        D+  +Y  KLWTAPE+LR    P  G  K DVYSF I+ QE+    GVFYI    +I  +I+   + +   P  RP L      +E G+      +++ CW E+P  RP F  IK+ LR+ +     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R +A M+LA L  +  FKI H+P QQL++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMES G+ LKIHVSE++++ L  F  F L  RG +++KGKG  +TYWL G
Sbjct:  536 GSLMTMEGNLQIYTKTGYYKGNLVAIKYI--NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS--CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHTLIPKEIIQGVI-RGGVPLLRPSLCFHSHSEELGV------LMQRCWCEEPGERPDFNTIKILLRKQHRGYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQG 1049          

Query:  235 EIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIAN--LIRI-RENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNR------SITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQI-TGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIE 1680
            E+ +A +LP  ++       +V PA+  A+D V ++ +L       + +  S +     S +  PL+A+D+   +     +GP  D+  + V R++++ + VP++TA   A   S    +  +T    T+K +     KI  TF W    +T ++F       D   C F    +  +   +     +            F+ S I +  L++I ++N R+  +C    N +R +M+      +    YV+F IDL A  + G +P        +++  A+ AFRSV  +++ +P +  Y  F+  +K+ ++  +N+  K    N   G F+D V+LY  ALN+TLS  +          G+ V   +WN +F G+ G + +D  G    D++L DM  I +G F VV  +    K LV+ +  N  W     S PL+ P CGF  D   C    +T   +  + I  + ++++   +   RK K++ EL +  W+++W DI+
Sbjct:   29 EVTLAAILPLTNTDYPWAWPRVAPALYRAVDSVNSDPHLLPGLKLQLVHGSSENREGFCSDSAAPLVAVDLKLSHDPWAFIGPGCDYSSSPVARFTTH-WDVPMVTAGARADGFSK---FAAVTNTGPTHKKLGEFSLKIQETFGW--HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDY-----------FVESNINHKELVQIIQKNGRVVYLCCSWDN-MRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQ 511          

Query: 1933 GIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGY-HGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRL-----EDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHG 3489
            G  ++   + Q++ KT  YK N+VA+K++    +RIE+ R +LF++K ++D++N H+ RFIG C+DP N CIITEYCP+GSLQD++E+E + LD +FR SL+ D+ +GM +L +++ + HGNLKSSNC+VDSRFVLKITD+GL + R        D+  +Y  KLWTAPE+LR    P  G  K DVYSF I+ QE+    GVFYI    +I  +I+   + +   P  RP L      +E G+      +++ CW E+P  RP F  IK+ LR+ +     +ILDNLL+RMEQYANNLE LV +RTQ Y EEKR+AE LLY +LP SVA QL RGE V AE+F+ VTIYFSDI GFTALSAESTP+QV+TLLN+LYT FD+I ++ DVYKVETIGDAYMVVSGLP RNG +H R +A M+LA L  +  FKI H+P QQL++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMES G+ LKIHVSE++++ L  F  F L  RG +++KGKG  +TYWL G
Sbjct:  477 GSLMTMEGNLQIYTKTGYYKGNLVAIKYIN--KKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS--CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHTLIPKEIIQGVI-RGGVPLLRPSLCFHSHSEELGV------LMQRCWCEEPGERPDFNTIKILLRKQHRGYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQG 990          

Query:  235 EIKIAVLLP-NDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNS-----SLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIAN--LIR-IRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKS--KSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGF--DGKKC--PPITPWXXXXXXXXXXXXXXXXXXXXXXRK-KMKTELESMDWKINWCDIE 1680
            E+ +A +LP  ++       +V PA+  A+D V ++ +L       + +  S +     S +  PL+A+D+   +     +GP  D+  + V R++++ + VP++TA   A   S    +  +T    T+K +     KI  TF W    +T ++F       D   C F    +  +   +     +            F+ S I +  L++ I++N R+  +C    N +R +M+      +    YV+F IDL A  + G +P  MP                     FR   D H      +V+  S   SF  Y+                       L+ T++  +S    +     +W     G+ G + +D  G    D++L DM  I           GK +   + +  N  W     S PL+ P CGF  D   C    +T   +  + I  + ++++   +   RK K++ EL +  W+++W DI+
Sbjct:   29 EVTLAAILPLTNTDYPWAWPRVAPALYRAVDSVNSDPHLLPGLKLQLVHGSSENREGFCSDSAAPLVAVDLKLSHDPWAFIGPGCDYSSSPVARFTTH-WDVPMVTAGARADGFSK---FAAVTNTGPTHKKLGEFSLKIQETFGW--HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDY-----------FVESNINHKELVQIIQKNGRVVYLCCSWDN-MRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKP-GMP--------------------WFRGDQDDHAARLAFRVRHPSIFNSFSVYN-----------------------LSTTIT-PQSFMQIKMCSEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINS---------GKFEVKHLPKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQ 452          

Query:   91 MKLSLSALMLSIFIVFLITLYLCSLCQAGKSYITRIIKPLDKSNESSLEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPTE 3525
            MKLS+SALMLSIFIVFLITLYLCSLCQAGKSYITRII+PLDKSNESSLEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSS YVRDIMLAAH LKLTNGEYVYFNIDLSANQIKG QPWYMPN+SKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWLVAV SIVVITIVLVISVVIFIRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKSISEVSRRSESSSSLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTL PVGLAKADVYSFAIVCQEIIYRSGVFYISDVDIISPDIVVDRVRKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPTE
Sbjct:    1 MKLSMSALMLSIFIVFLITLYLCSLCQAGKSYITRIIRPLDKSNESSLEIKIAVLLPNDSKSQCQLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSKYVRDIMLAAHQLKLTNGEYVYFNIDLSANQIKGHQPWYMPNESKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWLVAVFSIVVITIVLVISVVIFIRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYLNPKYQAKASKEGPNEFSPFISQSNNYRKSISEVSRRSESSSSLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGREISNHDSFQFYKNKLWTAPEVLRNPTLHPVGLAKADVYSFAIVCQEIIYRSGVFYISDVDIISPDIVVDRVRKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGDGDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPTE 1145          

Query:  208 LDKSNESSLEIKIAVLLPNDSKSQC-----QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMF-NDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSR---NSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGRE-ISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXK-IENPPFRPRLEDE-RGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPTE 3525
            ++  N    ++ I ++L N+S          L +++PA+D+A + +K +   FRN            S++      ID+  N     V+LGP++DF +AN VR S  RY+VP+LT  G A  L  K+ + MLT    T++D++ V   +F  F W P+SY  V  +    + D    +F +  +    +   +K   ++ EI+         +   NL  + +N+RI I+CAK    +RDIM AA+ L    G+Y + + D+  N+ +  +PWY P +S + N + K+A+RS++ ++   P+  ++  F  +VK+KSKS  +      D +  V  FHD+V++Y  ALN  L  +++++DG+ +   + N S NGI+G + ID NG   ADYSLLDMD  T  F VV    G +K      +  IDW N  N  PLDTP CGF    C       ++ + +V++ I  V+S+VI+   K   EL++M+W I W  IET EKR+ R S N    K  ++   I+ +  +S     S+   ++  +      N+      Q  ++R         + S +SL TLAGIQ   L + QMF+KT +YK  IVA+K + +  ++IEIN+ +L Q+K VKDLNN+HI RFIG CL+P + CI++EYCPKGSLQDVLEN+QIKLD +F+ SL+QD+CRGM+YL S IG HGNLKSSNCL+DSRFV+K+TDFGL   R  ++ +   + + FY+N LWTAPE+LRN      G  K D+YSFAI+ QEIIYR+GVFY+ + +       +    K     PFRP L  E      +I SII+  W+E P  RP    IK+  R+ N AGD G+ILDNLL+RMEQYANNLEGLV QRT+QY EEKR+AEDLLY MLPKSVA QLIR EPVTAES+E VTIYFSDI GFT+LSAESTPMQVI LLN+LYT FDSI E++DVYKVETIGDAY+VVSGLPQRNG +H R I+ MSLAFL  ++ F+IPH+ D+QL +RIGMH+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ +KIH+S ++   L TFG FI+TERG +++KGKG Q TYWLHG  E+IVD +  E
Sbjct:   14 INAENSKKHQMVIGIILENNSSQNHLGNLPTLDQIVPAVDIAFEKIKKKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFK---IAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPE-VIRDIMKAAYDLGFHKGDYAFISFDI-LNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGS-----QDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLF-QGGSFRN---ARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFTFQIPHRQDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPE 1115          

Query:  244 IAVLLPNDSKSQC-----QLIKVLPAIDVAIDHVKNERNLFRNATFSISYSDSNSSLAVGPLIAIDMF-NDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKIYPMLTRLSGTYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXXXXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSR---NSYLNPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGRE-ISNHDSFQFYKNKLWTAPEVLRNPTLPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXK-IENPPFRPRLEDE-RGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLPTE 3525
            I ++L N+S          L +++PA+D+A + +K +   FRN            S++      ID+  N     V+LGP++DF +AN VR S  RY+VP+LT  G A  L  K+ + MLT    T++D++ V   +F  F W P+SY  V  +    + D    +F +  +    +   +K   ++ EI+         +   NL  + +N+RI I+CAK    +RDIM AA+ L    G+Y + + D+  N+ +  +PWY P +S + N + K+A+RS++ ++   P+  ++  F  +VK+KSKS  +      D +  V  FHD+V++Y  ALN  L  +++++DG+ +   + N S NGI+G + ID NG   ADYSLLDMD  T  F VV    G +K      +  IDW N  N  PLDTP CGF    C       ++ + +V++ I  V+S+VI+   K   EL++M+W I W  IET EKR+ R S N    K  ++   I+ +  +S     S+   ++  +      N+      Q  ++R         + S +SL TLAGIQ   L + QMF+KT +YK  IVA+K + +  ++IEIN+ +L Q+K VKDLNN+HI RFIG CL+P + CI++EYCPKGSLQDVLEN+QIKLD +F+ SL+QD+CRGM+YL S IG HGNLKSSNCL+DSRFV+K+TDFGL   R  ++ +   + + FY+N LWTAPE+LRN      G  K D+YSFAI+ QEIIYR+GVFY+ + +       +    K     PFRP L  E      +I SII+  W+E P  RP    IK+  R+ N AGD G+ILDNLL+RMEQYANNLEGLV QRT+QY EEKR+AEDLLY MLPKSVA QLIR EPVTAES+E VTIYFSDI GFT+LSAESTPMQVI LLN+LYT FDSI E++DVYKVETIGDAY+VVSGLPQRNG +H R I+ MSLAFL  ++ F+IPH+ D+QL +RIGMH+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG+ +KIH+S ++   L TFG FI+TERG +++KGKG Q TYWLHG  E+IVD +  E
Sbjct:    3 IGIILENNSSQNHLGNLPTLDQIVPAVDIAFEKIKKKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFK---IAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPE-VIRDIMKAAYDLGFHKGDYAFISFDI-LNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGS-----QDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLF-QGGSFRN---ARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFTFQIPHRQDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPE 1092          

Query:  250 VLLPNDSKSQCQLIKVLPAIDVAIDHVK--NERNLFRNATFSISYSDSNSSLAVG--PLI-AIDMFNDNVANVLLGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKI--YPMLTRLSG--TYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXX---XXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYL----------------NPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGRE-ISNHDSFQFYKNKLWTAPEVLRNPT-LPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLP 3519
            +++P+D +       +L A D+A++ ++  N     R   +   Y+D++S       PL   + +   +   V  GP+ D+ LA + R   + + +PI+T  G +      K   Y  LTR++       ++ +F KIF  +NWS               ++    NF  R +  +F +  YK       + +  E      T+  +    ENA + ++C +  + VR I+L AH L   NGEYV+ NIDL  ++    +PWY  ND+ + N  AKEA+RS++TV+ ++P+ + Y +FI +VK ++   Y     ++++N  +G FHD+++LY LALN T+++N +  +G F+   +WN +  GITG++ ID+NG   ADYS+LDMD+ TG F +V  + GK +  +    + IDW N+KN  P   PVCG++ K CP        +  I +  I+L   +    I+ R K + EL +M+W I W ++ET+EKR R       +K S ++P   +++L   R  Y                 NP       K  P+  +      N++                  +  G+Q   L   + F  TA+YK N+VALK L    +++EINR +L ++K VK+LNN HI RFIG+CLD     ++TEYCPKGSLQD+LENEQI LD +F+ SL+QD+CRGM+YL S IG HGNLKSSNCLVDSRFVLKI DFGL   R  +E +  +D + +Y+N LWTAPE+LR  T +      KADVYSF I+CQE++YR+GVFY+SD+++    IV     K++  P+RP L +    ++ +  IIR  WQED +LRP F  IK  +R +N  GD G+ILDNLL+RMEQYANNLE LV QRT+QY EEKR+ EDLLYSMLPKSVAGQLIR E VTAES+E V+IYFSDI GFTALSAESTPMQVI LLN LYT FDSI E  DVYKVETIGDAYMV SGLPQRNG +H+R IA MSLAFLS I++F+IPHKP++++++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+SE S   L TF  FI+++RG V++KGKG Q TYWLHG    IVD +P
Sbjct:   43 IMIPDDIRHNFNKNLMLSAFDIALEKIRTWNIHPFIRKLKY---YADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPF-WDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLI----------YEQTFLNF-CRSVGTLFDSENYKNKTFKSVVLLNAE------TLLEIDMGSENA-VVVLCVEPES-VRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRL-----THKVSDTLP---NSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWE-----------------SFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVT-KVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 1110          

Query:  379 SDSNSSLAVGPLIAID-MFNDNVANVL----LGPVNDFLLANVVRYSSYRYKVPILTAQGYASDLSDKKI--YPMLTRLSG--TYKDMERVFEKIFATFNWSPKSYTTVVFWYIWHKFDAYECNFQTRPIMDIFKTNGYKFLELSDEIHMLTEHGFMNSTIANLIRIRENARITIICAKSSNYVRDIMLAAHHLKLTNGEYVYFNIDLSANQIKGLQPWYMPNDSKKNNVMAKEAFRSVITVSFRQPDDQHYTDFIIKVKEKSKSFYNYDYKIDDANSCVGRFHDAVVLYCLALNKTLSLNRSITDGEFVKNMIWNSSFNGITGKIIIDDNGAGFADYSLLDMDQITGNFLVVGTFYGKNKTLVMARDRNIDWANEKNSAPLDTPVCGFDGKKCPPITPWXXXXXXXXXXXXXXXXXXX---XXXRKKMKTELESMDWKINWCDIETQEKRQRRRSLNSANKKSASIPIFIHNQLNDSRNSYL----------------NPKYQAKASKEGPNEFSPFISQSNNYRKXXXXXXXXXXXXXXLLTLAGIQLSQLASTQMFAKTAIYKENIVALKHLRLEGRRIEINREILFQIKSVKDLNNNHIARFIGICLDPGNECIITEYCPKGSLQDVLENEQIKLDSVFRLSLMQDMCRGMLYLQSTIGYHGNLKSSNCLVDSRFVLKITDFGLSAFRIGRE-ISNHDSFQFYKNKLWTAPEVLRNPT-LPPVGLAKADVYSFAIVCQEIIYRSGVFYXXXXXXXXXXXXXXXXXKIENPPFRPRLEDERGINKDIISIIRSCWQEDPNLRPGFAQIKLKLRRINGAGD-GDILDNLLTRMEQYANNLEGLVAQRTQQYYEEKRRAEDLLYSMLPKSVAGQLIRGEPVTAESFEKVTIYFSDICGFTALSAESTPMQVITLLNNLYTLFDSITEDHDVYKVETIGDAYMVVSGLPQRNGIMHVRHIACMSLAFLSEIYKFKIPHKPDQQLKIRIGMHTGMVCAGVVGVKMPRYCLFGDTVNTASRMESNGKPLKIHVSESSKRELDTFGEFILTERGNVDIKGKGIQKTYWLHGTKENIVDQLP 3519
            + SN   ++ P I +      NV NV      GP+ D+ LA + R   + + +PI+T  G +      K   Y  LTR++       ++ +F KIF  +NWS               ++    NF  R +  +F +  YK       + +  E      T+  +    ENA + ++C +  + VR I+L AH L   NGEYV+ NIDL  ++    +PWY  ND+ + N  AKEA+RS++TV+ ++P+ + Y +FI +VK ++   Y     ++++N  +G FHD+++LY LALN T+++N +  +G F+   +WN +  GITG++ ID+NG   ADYS+LDMD+ TG F +V  + GK +  +    + IDW N+KN  P   PVCG++ K CP        +  I +  I+L   +    I+ R K + EL +M+W I W ++ET+EKR R       +K S ++P   +++L   R  Y                 NP       K  P+  +      N++                  +  G+Q   L   + F  TA+YK N+VALK L    +++EINR +L ++K VK+LNN HI RFIG+CLD     ++TEYCPKGSLQD+LENEQI LD +F+ SL+QD+CRGM+YL S IG HGNLKSSNCLVDSRFVLKI DFGL   R  +E +  +D + +Y+N LWTAPE+LR  T +      KADVYSF I+CQE++YR+GVFY+SD+++    IV     K++  P+RP L +    ++ +  IIR  WQED +LRP F  IK  +R +N  GD G+ILDNLL+RMEQYANNLE LV QRT+QY EEKR+ EDLLYSMLPKSVAGQLIR E VTAES+E V+IYFSDI GFTALSAESTPMQVI LLN LYT FDSI E  DVYKVETIGDAYMV SGLPQRNG +H+R IA MSLAFLS I++F+IPHKP++++++RIG+H+G VCAGVVG+KMPRYCLFGDTVNTASRMESNG PLKIH+SE S   L TF  FI+++RG V++KGKG Q TYWLHG    IVD +P
Sbjct:   24 TQSNRISSLDPKINVQSTVTTNVLNVFKYVWFGPICDYSLAPIARLLPF-WDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLI----------YEQTFLNF-CRSVGTLFDSENYKNKTFKSVVLLNAE------TLLEIDMGSENA-VVVLCVEPES-VRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRL-----THKVSDTLP---NSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWE-----------------SFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVT-KVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 1051