G protein regulated inducer of neurite outgrowth
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30015061 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 16
Homology
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Zebrafish
Match: si:dkeyp-123h10.2 (si:dkeyp-123h10.2 [Source:ZFIN;Acc:ZDB-GENE-090313-376]) HSP 1 Score: 51.9878 bits (123), Expect = 2.731e-6 Identity = 27/64 (42.19%), Postives = 40/64 (62.50%), Query Frame = 3 Query: 1500 KQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 K+ + E +DE+EN A + +S+ ++ +DE G TWE+YGA DPE LG AIQ+HL+ Sbjct: 474 KKLMPEKDDQDEEEN-AKQSKKSVH-------DVVWDEQGMTWEVYGASVDPESLGFAIQSHLQ 529
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Xenopus
Match: mrps7 (mitochondrial ribosomal protein S7 [Source:Xenbase;Acc:XB-GENE-974637]) HSP 1 Score: 52.7582 bits (125), Expect = 2.411e-6 Identity = 21/34 (61.76%), Postives = 26/34 (76.47%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLER 1694 K++ +DE G TWE+YGA DPE LG AIQ HL+R Sbjct: 632 KDVVWDEQGMTWEVYGASMDPEALGIAIQNHLQR 665
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Xenopus
Match: nrarp (NOTCH regulated ankyrin repeat protein [Source:Xenbase;Acc:XB-GENE-996958]) HSP 1 Score: 52.373 bits (124), Expect = 3.136e-6 Identity = 25/48 (52.08%), Postives = 33/48 (68.75%), Query Frame = 3 Query: 1551 PEDTESLQLLPLLP-KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 PE +LQ P P +E+ +D+ G TWE+YGA DPE+LG AIQ HL+ Sbjct: 489 PEVGLALQC-PRSPVREVRWDDEGMTWEVYGASMDPEVLGLAIQKHLD 535
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Mouse
Match: Gprin2 (G protein regulated inducer of neurite outgrowth 2 [Source:MGI Symbol;Acc:MGI:2444560]) HSP 1 Score: 50.447 bits (119), Expect = 7.538e-6 Identity = 19/33 (57.58%), Postives = 25/33 (75.76%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 +++ +D G TWE+YGA DPE+LG AIQ HLE Sbjct: 377 RDVRWDAEGMTWEVYGASVDPEVLGIAIQKHLE 409
BLAST of G protein regulated inducer of neurite outgrowth vs. UniProt/SwissProt
Match: sp|Q9PWA3|GRIN2_CHICK (GRIN2-like protein OS=Gallus gallus OX=9031 PE=1 SV=1) HSP 1 Score: 53.1434 bits (126), Expect = 8.327e-6 Identity = 20/33 (60.61%), Postives = 26/33 (78.79%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 +E+ +D+ G TWE+YGA DPE+LG AIQ HLE Sbjct: 428 REVRWDDEGMTWEVYGASVDPEVLGLAIQKHLE 460
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Match: A0A0R3W0V8 (GRIN_C domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS3329 PE=4 SV=1) HSP 1 Score: 72.0182 bits (175), Expect = 1.861e-9 Identity = 42/110 (38.18%), Postives = 63/110 (57.27%), Query Frame = 3 Query: 1371 RKVSAIAEEIESHAPTEYERRSSLANTQYDTIDKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLM 1700 R A A I+S APTE RR S + + +++ KQ +KQ ++ EDT+ + + P+E+ +D+ GQTWEIYGAD DP LGQAI++HLE+++ Sbjct: 177 RDSQAEATSIQSKAPTE--RRLSTSAPHLEALEQHHRDKQ--KKQAA-----------ASTEDTKKIISRSVRPREVNYDDQGQTWEIYGADQDPNALGQAIESHLEKMI 271
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Match: R7VD02 (GRIN_C domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_223299 PE=4 SV=1) HSP 1 Score: 71.633 bits (174), Expect = 5.023e-9 Identity = 69/210 (32.86%), Postives = 96/210 (45.71%), Query Frame = 3 Query: 1125 SNDNGIICTDMDLKAIINSFKREES----SLSINSNNAGQEKLKLSAN----ISKTPTASSSVIGPGFGKRKLMRKQVSFDDEQGVMMINRKVSAIAEEIESHAPTEY--ERRSSLAN--TQYDTIDKETLGKQ----TMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLP-KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLMI 1703 S+D+G+IC+ +DLKA+ FK+ S + S + Q KL S N +S +A SSV GK +D E + E + S P+EY + R L D T+G T++ L+ S E T Q PL P EI FD GQTW++YGA+ DPE+LG+AIQ HL +LM+ Sbjct: 396 SSDSGVICSSVDLKAMKTDFKKRRSPRPSKQDLRSLSVDQTKLLDSQNSMESVSSGYSAQSSV---SAGK---------YDAE------------VDEGLTSDTPSEYSAQMRQPLVPRIVGGDGSQNRTVGDGGQNITLQNATLLY--------GSLDESTPGCQDEPLKPIPEIVFDAQGQTWDVYGAEFDPEVLGEAIQRHLVKLML 573
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Match: A0A0R3SV56 (GRIN_C domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS9430 PE=4 SV=1) HSP 1 Score: 68.9366 bits (167), Expect = 2.017e-8 Identity = 28/62 (45.16%), Postives = 41/62 (66.13%), Query Frame = 3 Query: 1515 EMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLM 1700 E+ + N++ + S + + P+E+ +DE GQTWEIYGAD DP LGQAI+ HLE++M Sbjct: 211 ELEIKKNQSNTSSTEAGSFVVKSIRPREVSYDEKGQTWEIYGADQDPNALGQAIENHLEKMM 272
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Match: A0A068Y9L5 (G protein regulated inducer of neurite outgrowth OS=Echinococcus multilocularis OX=6211 PE=4 SV=1) HSP 1 Score: 68.5514 bits (166), Expect = 2.875e-8 Identity = 38/113 (33.63%), Postives = 62/113 (54.87%), Query Frame = 3 Query: 1362 MINRKVSAIAEEIESHAPTEYERRSSLANTQYDTIDKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLM 1700 ++ R A E I+S ++ERR S + D +++ + KQ + +E TK+ + + P +E+ +D+ GQTWEIYGAD DP LGQAI++HLE+++ Sbjct: 251 LLFRDSQAEVESIKS--KEQWERRLSTSALHLDGLEQHHIEKQKKQAAATIEDTKKTFSKGNRP-------------REVNYDDQGQTWEIYGADQDPNALGQAIESHLEKMI 348
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Match: W6V7I8 (G protein-regulated inducer of neurite outgrowth 3 OS=Echinococcus granulosus OX=6210 GN=EGR_02872 PE=4 SV=1) HSP 1 Score: 68.1662 bits (165), Expect = 3.600e-8 Identity = 38/113 (33.63%), Postives = 61/113 (53.98%), Query Frame = 3 Query: 1362 MINRKVSAIAEEIESHAPTEYERRSSLANTQYDTIDKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLM 1700 ++ R A E I+S P ERR S + D +++ + KQ + +E T++ + + P +E+ +D+ GQTWEIYGAD DP LGQAI++HLE+++ Sbjct: 174 LLFRDSQAEVESIKSKEP--RERRLSTSALHLDGLEQHHMDKQKKQVAATIEDTRKTFSKGNRP-------------REVNYDDQGQTWEIYGADQDPNALGQAIESHLEKMI 271
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Cavefish
Match: ENSAMXT00000025937.2 (pep primary_assembly:Astyanax_mexicanus-2.0:4:6690721:6698708:-1 gene:ENSAMXG00000025211.2 transcript:ENSAMXT00000025937.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 52.373 bits (124), Expect = 1.635e-6 Identity = 22/33 (66.67%), Postives = 25/33 (75.76%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 KE+E+D G TWE+YGA DPE LG AIQ HLE Sbjct: 411 KEVEWDAEGMTWEVYGASLDPEELGLAIQRHLE 443
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Cavefish
Match: si:dkey-191g9.7 (uncharacterized LOC103041404 [Source:NCBI gene;Acc:103041404]) HSP 1 Score: 51.6026 bits (122), Expect = 2.873e-6 Identity = 21/33 (63.64%), Postives = 25/33 (75.76%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 KE+++D G TWE+YGA DPE LG AIQ HLE Sbjct: 401 KEVKWDAEGMTWEVYGASVDPEELGLAIQKHLE 433
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Medaka
Match: si:dkey-191g9.7 (G protein regulated inducer of neurite outgrowth 2 [Source:NCBI gene;Acc:105357946]) HSP 1 Score: 50.0618 bits (118), Expect = 5.480e-6 Identity = 20/33 (60.61%), Postives = 25/33 (75.76%), Query Frame = 3 Query: 1593 KEIEFDEYGQTWEIYGADPDPEILGQAIQTHLE 1691 K++++D G TWE+YGA DPE LG AIQ HLE Sbjct: 264 KDVKWDAEGMTWEVYGASVDPEELGLAIQRHLE 296
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Medaka
Match: ENSORLT00000028169.1 (G protein-regulated inducer of neurite outgrowth 3-like [Source:NCBI gene;Acc:105354446]) HSP 1 Score: 49.6766 bits (117), Expect = 9.698e-6 Identity = 23/48 (47.92%), Postives = 31/48 (64.58%), Query Frame = 3 Query: 1596 EIEFDEYGQTWEIYGADPDPEILGQAIQTHL-------ERLMICRQSL 1718 ++ +DE G TWE+YGA DPE LG AIQ+HL ER +I + S+ Sbjct: 325 DVVWDEQGMTWEVYGASVDPESLGFAIQSHLQCKIKEQERKLIVQTSI 372
BLAST of G protein regulated inducer of neurite outgrowth vs. Planmine SMEST
Match: SMESG000062691.1 (SMESG000062691.1) HSP 1 Score: 1159.05 bits (2997), Expect = 0.000e+0 Identity = 594/598 (99.33%), Postives = 594/598 (99.33%), Query Frame = 3 Query: 180 MSVLGYDNSNKSLNNIYVDIPLTNNRLRQRRSLDYGKSGFILAGPNRQKSFTTXXXXXXXXXXXXXXCNFNSSAPIPKPQISIRRQSSERCLIKRHSVDSNKSNISDPGYSLINTKNCAGSNFLIPSQQRSPKESNSPRSYYSSVASVAGRQASYASISLLSRQNSINSSNLMGKQQSNDNLENRKWFSSSSVILTRVKSMKDKFRRVVVQSVQPDDWPPPSILFSERYRYPXXXXXXXXXXXXKFSQNMHKETAHLIKSKSVDQSSFPSSINNSNRKSTRNPNPAGSGRQFKRGKLQRSMTAYSSTNDPLEHITSNDNGIICTDMDLKAIINSFKREESSLSINSNNAGQEKLKLSANISKTPTASSSVIGPGFGKRKLMRKQVSFDDEQGVMMINRKVSAIAEEIESHAPTEYERRSSLANTQYDTIDKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLMICRQSLTISNGNANISKPKVPDDFGLTKTEIPKRILKPLRVDLESSENHLRLIARRLCGKWSCFSDSRQQSNSSKFTGIGQKITVSVDKES 1973 MSVLGYDNSNKSLNNIYVDIPLTNNRLRQRRSLDYGKSGFILAGPNRQKSF TSHHYSIPSSPSHNSCNFNSSAPI KPQISIRRQSSERCLIKRHSVDSNKSNISDPGYSLINTKNCAGSNFLIPSQQRSPKESNSPRSYYSSVASVAGRQASYASISLLSRQNSINSSNLMGKQQSNDNLENRKWFSSSSVILTRVKSMKDKFRRVVVQSVQPDDWPPPSILFSERYRYPSSSSCQSANVSSKFSQNMHKETAHLIKSKSVDQSSFPSSINNSNRKSTRNPNPAGSGRQFKRGKLQRSMTAYSSTNDPLEHITSNDNGIICTDMDLKAIINSFKREESSLSINSNNAGQEKLKLSANISKTPTASSSVIGPGFGKRKLMRKQVSFDDEQGVMMINRKVSAIAEEIESHAPTEYERRSSLANTQYDT DKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLMICRQSLTISNGNANISKPKVPDDFGLTKTEIP RILKPLRVDLESSENHLRLIARRLCGKWSCFSDSRQQSNSSKFTGIGQKITVSVDKES Sbjct: 1 MSVLGYDNSNKSLNNIYVDIPLTNNRLRQRRSLDYGKSGFILAGPNRQKSFNTSHHYSIPSSPSHNSCNFNSSAPISKPQISIRRQSSERCLIKRHSVDSNKSNISDPGYSLINTKNCAGSNFLIPSQQRSPKESNSPRSYYSSVASVAGRQASYASISLLSRQNSINSSNLMGKQQSNDNLENRKWFSSSSVILTRVKSMKDKFRRVVVQSVQPDDWPPPSILFSERYRYPSSSSCQSANVSSKFSQNMHKETAHLIKSKSVDQSSFPSSINNSNRKSTRNPNPAGSGRQFKRGKLQRSMTAYSSTNDPLEHITSNDNGIICTDMDLKAIINSFKREESSLSINSNNAGQEKLKLSANISKTPTASSSVIGPGFGKRKLMRKQVSFDDEQGVMMINRKVSAIAEEIESHAPTEYERRSSLANTQYDTTDKETLGKQTMEKQYLVEMTKEDEDENSAPEDTESLQLLPLLPKEIEFDEYGQTWEIYGADPDPEILGQAIQTHLERLMICRQSLTISNGNANISKPKVPDDFGLTKTEIPNRILKPLRVDLESSENHLRLIARRLCGKWSCFSDSRQQSNSSKFTGIGQKITVSVDKES 598 The following BLAST results are available for this feature:
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of G protein regulated inducer of neurite outgrowth vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 1
BLAST of G protein regulated inducer of neurite outgrowth vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of G protein regulated inducer of neurite outgrowth vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of G protein regulated inducer of neurite outgrowth vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30015061 ID=SMED30015061|Name=G protein regulated inducer of neurite outgrowth|organism=Schmidtea mediterranea sexual|type=transcript|length=2408bpback to top protein sequence of SMED30015061-orf-1 >SMED30015061-orf-1 ID=SMED30015061-orf-1|Name=SMED30015061-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=599bp MSVLGYDNSNKSLNNIYVDIPLTNNRLRQRRSLDYGKSGFILAGPNRQKSback to top Aliases
The feature 'G protein regulated inducer of neurite outgrowth' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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