Cullin-3

Overview
NameCullin-3
Smed IDSMED30015048
Length (bp)4621
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cullin-3 (SMED30015048) t-SNE clustered cells

Violin plots show distribution of expression levels for Cullin-3 (SMED30015048) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cullin-3 (SMED30015048) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cullin-3 (SMED30015048) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30015048

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30015048h1SMcG0002989 Contig14510uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015048h1SMcG0002989 Contig14510newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015048h1SMcG0002989 Contig50394uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015048h1SMcG0002989 Contig50394newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
neuronSMED30015048h1SMcG0002989 Contig18900uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30015048h1SMcG0002989 Contig18900newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30015048h1SMcG0002989 HO005153smed_ncbi_20240424PMID:29291974
Strand et al., 2018
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 211.075 bits (536), Expect = 8.575e-60
Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  111 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 342          
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 209.92 bits (533), Expect = 6.126e-56
Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702          
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 209.92 bits (533), Expect = 1.199e-55
Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  513 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744          
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 209.92 bits (533), Expect = 1.199e-55
Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  513 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744          
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 209.92 bits (533), Expect = 1.629e-55
Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 170.244 bits (430), Expect = 2.711e-47
Identity = 108/260 (41.54%), Postives = 167/260 (64.23%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFI-ATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++Y  KH GR + +   LGN ++ A +    P    S++  +    P+      S + + +                   ILQV+T+QMIIL++FN  ++ S ++L++E KIPER+L R L SL+L K++QRIL++  KNK  + I  +D F++N++F SK  ++K+Q +    E+EPE++ET+ KV+++RK  +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A
Sbjct:    4 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVR--KNKGKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 240          
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 167.548 bits (423), Expect = 2.342e-42
Identity = 104/259 (40.15%), Postives = 163/259 (62.93%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++Y  KH GR + +   LGN ++ A +     ++  +     G S    +   +  +                       ILQV+T+QMIIL++FN  ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+     +D F++N++F SK  ++K+Q +    E+EPE++ET+ KV+++RK  +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A
Sbjct:  481 QYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKERKPE---------------------HKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 717          
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42
Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++Y  KH GR + +   LGN ++ A +    P    S++  +    P+      S + + +                   ILQV+T+QMIIL++FN  ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+     +D F++N++F SK  ++K+Q +    E+EPE++ET+ KV+++RK  +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A
Sbjct:  541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777          
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42
Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++Y  KH GR + +   LGN ++ A +    P    S++  +    P+      S + + +                   ILQV+T+QMIIL++FN  ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+     +D F++N++F SK  ++K+Q +    E+EPE++ET+ KV+++RK  +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A
Sbjct:  541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777          
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42
Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++Y  KH GR + +   LGN ++ A +    P    S++  +    P+      S + + +                   ILQV+T+QMIIL++FN  ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+     +D F++N++F SK  ++K+Q +    E+EPE++ET+ KV+++RK  +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A
Sbjct:  541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777          
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302158)

HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53
Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR + LQP +G    TAY      + F    A +  SE + +    SS   G               + RK ILQVSTYQM +L+ FN +   +Y+++ +ET IPER+L R L SLS+ K  QR+L++  K K  +   TD F +N++F SK  ++KIQ++A K     E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V  QLKSRF+P+P  IK+RIE L+ER+YL RS +DRKVY+YLA
Sbjct:  538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773          
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302157)

HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53
Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR + LQP +G    TAY      + F    A +  SE + +    SS   G               + RK ILQVSTYQM +L+ FN +   +Y+++ +ET IPER+L R L SLS+ K  QR+L++  K K  +   TD F +N++F SK  ++KIQ++A K     E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V  QLKSRF+P+P  IK+RIE L+ER+YL RS +DRKVY+YLA
Sbjct:  538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773          
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302156)

HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53
Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR + LQP +G    TAY      + F    A +  SE + +    SS   G               + RK ILQVSTYQM +L+ FN +   +Y+++ +ET IPER+L R L SLS+ K  QR+L++  K K  +   TD F +N++F SK  ++KIQ++A K     E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V  QLKSRF+P+P  IK+RIE L+ER+YL RS +DRKVY+YLA
Sbjct:  538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773          
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302159)

HSP 1 Score: 202.216 bits (513), Expect = 1.336e-52
Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR + LQP +G    TAY      + F    A +  SE + +    SS   G               + RK ILQVSTYQM +L+ FN +   +Y+++ +ET IPER+L R L SLS+ K  QR+L++  K K  +   TD F +N++F SK  ++KIQ++A K     E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V  QLKSRF+P+P  IK+RIE L+ER+YL RS +DRKVY+YLA
Sbjct:  699 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934          
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul4 (gene:FBgn0033260 transcript:FBtr0301355)

HSP 1 Score: 129.028 bits (323), Expect = 9.397e-30
Identity = 93/258 (36.05%), Postives = 134/258 (51.94%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            +FYL KH+GR +  QP LGN  L A +                                 D G                  L VS +Q ++L+ FN K   SYEE++  T I + +L R L SL+  ++  R++ K PK +  E +  D F  N  FT+K  +IKI  I +KET  E K T+ +V ++R+Y I+A IVRIMK RK+L+HNLL+ E+  QL   F   P  +K+RIESL++RDY+ R  D++  Y+Y+A
Sbjct:  618 KFYLEKHSGRKLQWQPTLGNCMLRAQF---------------------------------DAGPKE---------------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRA--RVITKTPKGR--EILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLT--FPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821          
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376])

HSP 1 Score: 207.223 bits (526), Expect = 8.954e-55
Identity = 123/260 (47.31%), Postives = 172/260 (66.15%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG               VG  GA     +       RK ILQVST+QM ILM FN + K+++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  543 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDGSD-------------VGVGGALLTGSNT------RKHILQVSTFQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774          
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul3b (cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1])

HSP 1 Score: 203.756 bits (517), Expect = 1.115e-53
Identity = 123/260 (47.31%), Postives = 172/260 (66.15%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG            S +VG  GA     +       RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTS+  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  536 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG------------SDMVG--GAQVTGSNT------RKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSRLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766          
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 128.642 bits (322), Expect = 1.960e-29
Identity = 94/257 (36.58%), Postives = 134/257 (52.14%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A                       F +G +                           LQVS +Q ++L+ FN   ++S E++   T I + +L R L SL+  K+  R+L K PK+K+ E    D FS N+ F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y+Y+A
Sbjct:  662 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGKA--RVLTKIPKSKDVE--DGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 864          
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032])

HSP 1 Score: 111.694 bits (278), Expect = 2.210e-24
Identity = 76/181 (41.99%), Postives = 110/181 (60.77%), Query Frame = 1
Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            + ++  V+TYQM +L+ FN     SY+EL + T++ E++L + + SL   K     L KE      E     TFS+  SFTSK  K KI +   K+T  E+++T++ VDE+RK  ++A IVRIMKARK L HN L+ EVI Q K+RF P+  MIK+ IE L+++ Y+ RS      Y Y+A
Sbjct:  571 KPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKE------EIEPESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA 745          
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032])

HSP 1 Score: 111.694 bits (278), Expect = 2.343e-24
Identity = 76/181 (41.99%), Postives = 110/181 (60.77%), Query Frame = 1
Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            + ++  V+TYQM +L+ FN     SY+EL + T++ E++L + + SL   K     L KE      E     TFS+  SFTSK  K KI +   K+T  E+++T++ VDE+RK  ++A IVRIMKARK L HN L+ EVI Q K+RF P+  MIK+ IE L+++ Y+ RS      Y Y+A
Sbjct:  584 KPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKE------EIEPESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA 758          
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 211.46 bits (537), Expect = 1.996e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702          
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 211.075 bits (536), Expect = 5.927e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 211.075 bits (536), Expect = 6.142e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  539 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770          
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 211.075 bits (536), Expect = 6.791e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  539 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770          
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul4a (cullin 4A [Source:NCBI gene;Acc:548647])

HSP 1 Score: 132.88 bits (333), Expect = 6.294e-31
Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A + + +                                                  LQVS +Q ++L+ FN+  ++ +EE+   T I + +L R L SL+  K+  R+L K PK+K+ E    D F  N  F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L HNLLV+E+  QLK  F   P  +K+RIESL++RDY+ R  D+ K YHYLA
Sbjct:  502 FYLGKHSGRRLQWQSTLGHAVLKADFKEEKKE------------------------------------------------LQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKA--RVLNKSPKSKDVE--DGDRFCFNADFKHKLYRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLTHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA 704          
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360])

HSP 1 Score: 211.46 bits (537), Expect = 1.484e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702          
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360])

HSP 1 Score: 211.075 bits (536), Expect = 4.530e-56
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4a (cullin 4A [Source:MGI Symbol;Acc:MGI:1914487])

HSP 1 Score: 132.109 bits (331), Expect = 1.309e-30
Identity = 94/257 (36.58%), Postives = 129/257 (50.19%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A                      +F +G +                            QVS +Q ++L+ FN    +S+EE+   T I + +L R L SL+  K+  R+L+K PK K  E    D F  N  F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L HNLLV+E+  QLK  F   P  +K+RIESL++RDY+ R  D    YHY+A
Sbjct:  557 FYLGKHSGRKLQWQTTLGHAVLKA----------------------DFKEGKKE--------------------------FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVE--DGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759          
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834])

HSP 1 Score: 130.183 bits (326), Expect = 8.729e-30
Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A                       F +G +                           LQVS +Q ++L+ FN   ++S EE+   T I + +L R L SL+  K+  R+L K PK K+ E    D F  N+ F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y+Y+A
Sbjct:  768 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIE--DGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970          
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834])

HSP 1 Score: 130.183 bits (326), Expect = 8.729e-30
Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A                       F +G +                           LQVS +Q ++L+ FN   ++S EE+   T I + +L R L SL+  K+  R+L K PK K+ E    D F  N+ F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y+Y+A
Sbjct:  768 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIE--DGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970          
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q6GPF3|CUL3B_XENLA (Cullin-3-B OS=Xenopus laevis OX=8355 GN=cul3b PE=1 SV=1)

HSP 1 Score: 211.846 bits (538), Expect = 1.568e-55
Identity = 126/260 (48.46%), Postives = 176/260 (67.69%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       + ++   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGAVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q6DE95|CUL3A_XENLA (Cullin-3-A OS=Xenopus laevis OX=8355 GN=cul3a PE=1 SV=1)

HSP 1 Score: 211.075 bits (536), Expect = 2.946e-55
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNRDKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|A4IHP4|CUL3_XENTR (Cullin-3 OS=Xenopus tropicalis OX=8364 GN=cul3 PE=2 SV=1)

HSP 1 Score: 211.075 bits (536), Expect = 3.140e-55
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q9JLV5|CUL3_MOUSE (Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=1)

HSP 1 Score: 211.075 bits (536), Expect = 3.169e-55
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|B5DF89|CUL3_RAT (Cullin-3 OS=Rattus norvegicus OX=10116 GN=Cul3 PE=1 SV=2)

HSP 1 Score: 211.075 bits (536), Expect = 3.227e-55
Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768          
BLAST of Cullin-3 vs. TrEMBL
Match: G4VPI8 (Putative cullin OS=Schistosoma mansoni OX=6183 GN=Smp_031000.3 PE=3 SV=1)

HSP 1 Score: 261.151 bits (666), Expect = 2.110e-69
Identity = 146/260 (56.15%), Postives = 185/260 (71.15%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVS---EPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KHNGR INLQ N+G  EL+A +    P   ++L   + +S    PN                            +RK+ LQVSTYQMIILMKFNR+++YS+ EL  ET IPER+L R L++L+L + +QRIL KEPK ++ E  +TD F +N+SF SKHIK+++QSI VKE+EPE +ET+ KVDENR+YVIEATIVR+MKARK+L+H  LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA
Sbjct:  537 FYLSKHNGRKINLQTNMGYAELSAVFYGRSPGAPKTLDPPNLISTSSRPN----------------------------VRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 766          
BLAST of Cullin-3 vs. TrEMBL
Match: G4VPI9 (Putative cullin OS=Schistosoma mansoni OX=6183 GN=Smp_031000.2 PE=3 SV=1)

HSP 1 Score: 257.299 bits (656), Expect = 7.747e-68
Identity = 154/279 (55.20%), Postives = 198/279 (70.97%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYM---QSQPSTFQSLTATD---------GVSEPN--FNQGYQSSQIVGDVGAXXXXXX--------XXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KHNGR INLQ N+G  EL+A +     +  +T Q  + TD         G S  N   +Q  Q + I G  G+     +         S+  ++RK+ LQVSTYQMIILMKFNR+++YS+ EL  ET IPER+L R L++L+L + +QRIL KEPK ++ E  +TD F +N+SF SKHIK+++QSI VKE+EPE +ET+ KVDENR+YVIEATIVR+MKARK+L+H  LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA
Sbjct:  537 FYLSKHNGRKINLQTNMGYAELSAVFYGRPNADINTPQISSVTDSHIHSFLIHGSSSSNQVTSQSSQQTPISGLPGSPGAPKTLDPPNLISTSSRPNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 813          
BLAST of Cullin-3 vs. TrEMBL
Match: A0A5K4F8C9 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 256.914 bits (655), Expect = 1.260e-67
Identity = 154/281 (54.80%), Postives = 198/281 (70.46%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYM---QSQPSTFQSLTATD---------GVSEPNFNQGYQS-------SQIVGDVGAXXX-----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KHNGR INLQ N+G  EL+A +     +  ST Q  + TD         G S  + NQ           S + G  GA  +     S S ++  ++RK+ LQVSTYQMIILMKFNR+++YS+ EL  ET IPER+L R L++L+L + +QRIL KEPK ++ E  +TD F +N+SF SKHIK+++Q I VKE+EPE +ET+ KVDENR+YVIEATI+R+MKARK+L+H  LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA
Sbjct:  537 FYLSKHNGRKINLQTNMGYAELSAVFYGRPNADISTPQISSVTDSHTHGFLIHGSSSASLNQMTSQSSQQSPISGLPGSPGAPKSLDPPNSISTTSRSNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQGITVKESEPERQETRTKVDENRRYVIEATIMRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 815          
BLAST of Cullin-3 vs. TrEMBL
Match: A0A183SVC2 (Cullin-3 OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS8170 PE=3 SV=1)

HSP 1 Score: 256.529 bits (654), Expect = 1.307e-67
Identity = 149/266 (56.02%), Postives = 198/266 (74.44%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTA-YYMQSQPSTFQSLT----ATDGVSEPNFNQGYQSSQIVGDVGAXXX----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR I+L  NLG+ EL+A ++  S  ST Q       A  G S  + +     S + G  G S      S + ++  + RK+ILQVSTYQM+ILM FNR++++++ EL+ +T IPERDL R L++LSLS+STQRIL KEPK+K  EF  TD F++N++FTS+H K+K+Q+IAV+E+EPE +ET+ ++DENR+YVIEATIVRIMK RK+L HN L+AEVIEQLKSRF PTP  IKQRIE+L+ER+++ARSD DRKVY YLA
Sbjct:  533 FYLSKHSGRKISLHTNLGHAELSALFFGNSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQASASRANARKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 796          
BLAST of Cullin-3 vs. TrEMBL
Match: A0A0X3PL62 (Cullin-3 (Fragment) OS=Schistocephalus solidus OX=70667 GN=CUL3 PE=3 SV=1)

HSP 1 Score: 256.144 bits (653), Expect = 1.489e-67
Identity = 149/266 (56.02%), Postives = 198/266 (74.44%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTA-YYMQSQPSTFQSLT----ATDGVSEPNFNQGYQSSQIVGDVGAXXX----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYL KH+GR I+L  NLG+ EL+A ++  S  ST Q       A  G S  + +     S + G  G S      S + ++  + RK+ILQVSTYQM+ILM FNR++++++ EL+ +T IPERDL R L++LSLS+STQRIL KEPK+K  EF  TD F++N++FTS+H K+K+Q+IAV+E+EPE +ET+ ++DENR+YVIEATIVRIMK RK+L HN L+AEVIEQLKSRF PTP  IKQRIE+L+ER+++ARSD DRKVY YLA
Sbjct:  538 FYLSKHSGRKISLHTNLGHAELSALFFGNSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQASASRANARKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 801          
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul3b (cullin 3 [Source:NCBI gene;Acc:103024283])

HSP 1 Score: 206.838 bits (525), Expect = 8.719e-55
Identity = 122/260 (46.92%), Postives = 173/260 (66.54%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       + ++   DG      + G   +Q+ G               + RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  536 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGAIKKEDGS-----DIGVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 767          
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376])

HSP 1 Score: 204.527 bits (519), Expect = 1.579e-53
Identity = 124/260 (47.69%), Postives = 172/260 (66.15%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G+ +L A +       +  +   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN + K  +EE+ +ET IPER+L R L SL+  K+TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL+ RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  655 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKCVFEEIQQETDIPERELVRALQSLACGKTTQRVLTKEPKSKEIE--NGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRVRFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 886          
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul4a (cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357])

HSP 1 Score: 130.568 bits (327), Expect = 1.096e-30
Identity = 93/257 (36.19%), Postives = 132/257 (51.36%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  QP LG+  L A                       F +G +                           LQVS +Q ++L+ FN   +++ EE+   T I E +L R L SL+  K+  R+L K P+ K+ E    D F+ N  F  K  +IKI  I +KET  E   T  +V ++R+Y I+A +VRIMK RK+L+HNLLV+E+  QLK  F   P  +K+RIESL++RDY+ R  +    YHY+A
Sbjct:  410 FYLGKHSGRKLQWQPTLGHAVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFTLEEIQTATGIEEGELKRTLQSLACGKA--RVLNKNPRGKDVE--DGDRFNFNIDFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKESPNQYHYVA 612          
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: ENSAMXT00000057183.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001049.1:257741:270576:1 gene:ENSAMXG00000034138.1 transcript:ENSAMXT00000057183.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 129.028 bits (323), Expect = 3.935e-30
Identity = 95/257 (36.96%), Postives = 134/257 (52.14%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  Q  LG+  L A                       F +G +                           LQVS +Q ++L+ FN   ++S EE+   T I + +L R L SL+  K+  R+L K PK+K+ E    D FS N+ F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y+Y+A
Sbjct:  433 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGKA--RVLTKIPKSKDVE--DGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 635          
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul2 (cullin 2 [Source:NCBI gene;Acc:103040496])

HSP 1 Score: 114.775 bits (286), Expect = 2.551e-25
Identity = 75/181 (41.44%), Postives = 110/181 (60.77%), Query Frame = 1
Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            + ++  V+TYQM +L+ FN      Y+EL + T++ E++L + + SL   K       KE      E  A  TFS+N SFTSK  K KI +   ++T  E+++T++ VDE+RK  ++A IVRIMKARK L HN L+ EVI Q K+RF P+  MIK+ IE L+++ Y+ RS      Y Y+A
Sbjct:  571 KPYVAMVTTYQMAVLLAFNNSETVGYKELQDSTQMSEKELQKTIKSLLDVKMINHDSQKE------EIEAESTFSLNMSFTSKRTKFKITTSMQRDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKILRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQTSADEYSYVA 745          
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032])

HSP 1 Score: 108.612 bits (270), Expect = 3.721e-24
Identity = 71/185 (38.38%), Postives = 110/185 (59.46%), Query Frame = 1
Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLT---RCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQS-IAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            + ++  V+TYQM +L+ FN   + +Y EL   T++ ER+L    R LI + L  S+          K  E      FS+N  F+SK  K KI S +     + EV++T++ VDE+RK  ++A IVRIMK+RK L HN L+ EVI Q ++RF+P+  MIK+ IE L+++ Y+ R+ +    Y+Y+A
Sbjct:  569 KPYVATVTTYQMGVLLAFNGAEQVTYRELEYSTQLNERELVKTIRSLIDVKLVNSS---------GKEDEITPECIFSLNMEFSSKRTKFKITSAMQKDTPQQEVEQTRSAVDEDRKMYLKAAIVRIMKSRKVLKHNALIQEVISQSRARFIPSVSMIKKCIEDLIDKQYIERNQNSTDEYNYVA 744          
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887])

HSP 1 Score: 98.5969 bits (244), Expect = 5.695e-21
Identity = 67/183 (36.61%), Postives = 107/183 (58.47%), Query Frame = 1
Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESF---TSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++ LQ ST+QM +L+++N +  Y+ ++L E T+I    L + L  L  SK    +L+ E +N N + +     ++   F    +K +++ I      E + E + T   ++E+RK VI+A IVRIMK RK L H  L+AEV+ QL SRF P   +IK+ I+ L+E++YL R D ++  Y YLA
Sbjct:  597 RYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMDILVQVLQILLKSK----LLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 775          
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887])

HSP 1 Score: 95.9005 bits (237), Expect = 3.708e-20
Identity = 64/185 (34.59%), Postives = 109/185 (58.92%), Query Frame = 1
Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEET--KIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESF---TSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++ LQ ST+QM +L+++N +  Y+ ++L E T  K+  +D+   ++ + L     ++L+ E +N N + +     ++   F    +K +++ I      E + E + T   ++E+RK VI+A IVRIMK RK L H  L+AEV+ QL SRF P   +IK+ I+ L+E++YL R D ++  Y YLA
Sbjct:  556 RYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMKTKDILVQVLQILLKS---KLLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 737          
BLAST of Cullin-3 vs. Ensembl Yeast
Match: CUL3 (Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 [Source:SGD;Acc:S000003235])

HSP 1 Score: 68.1662 bits (165), Expect = 7.230e-12
Identity = 53/182 (29.12%), Postives = 90/182 (49.45%), Query Frame = 1
Query: 3922 LQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAX-----XXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            +  S Y  +I + F    + +  E+ E T IP  D+   ++S+S +    +IL K   + N +F      S+N  F+S + K+K+  IA      K        + +  D      + A IVRIMK    L+H  L+    ++ +SR   TP ++K+ I+ L+E++Y+ R+ DD   YHYL+
Sbjct:  570 ISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMS-TIPRCKILKKSSSSGNMKF------SVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS 744          
BLAST of Cullin-3 vs. Ensembl Yeast
Match: CDC53 (Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant [Source:SGD;Acc:S000002290])

HSP 1 Score: 63.1586 bits (152), Expect = 2.679e-10
Identity = 33/70 (47.14%), Postives = 44/70 (62.86%), Query Frame = 1
Query: 4243 RKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            R+  +EA IVRIMKA+++L H  LV E I Q   RF     M+K+ I+SL+++ YL R DD    Y YLA
Sbjct:  747 RQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGES-YAYLA 815          
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO35230 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM65])

HSP 1 Score: 218.009 bits (554), Expect = 1.930e-59
Identity = 131/264 (49.62%), Postives = 171/264 (64.77%), Query Frame = 1
Query: 3667 INCL-RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
             +C  RFYLG H+GR + LQP LG  EL A +                   P   +G    Q                    RK I Q+S+YQM ILM FN + +++YE+++++T IPERDL R L SL+  K+TQR+L KEPK K+    ATD FS+N+ FTSK  ++KIQ++ A  E+EPE KET+ KVDE+RK+ IEA IVRIMKARK   HNLLVAEV EQLK+RF+P+PQ+IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  471 FDCFKRFYLGNHSGRQLTLQPQLGTAELNATF------------------PPVKKEGASLGQ--------------------RKHIFQMSSYQMCILMLFNSQERWTYEDILQQTLIPERDLNRALQSLACGKATQRVLSKEPKGKD--ITATDVFSVNDLFTSKLHRVKIQTVLAKGESEPERKETRTKVDEDRKHEIEAAIVRIMKARKKRPHNLLVAEVTEQLKARFLPSPQVIKKRIEGLIEREYLARTPEDRKVYLYVA 694          
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO35660 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKY8])

HSP 1 Score: 120.939 bits (302), Expect = 3.991e-28
Identity = 87/258 (33.72%), Postives = 134/258 (51.94%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            +FYL KH+GR +  Q  LG+  + A + + +                                                  LQVS +Q ++L+ FN  ++YS E++ + T + + +L R L SL+  K+  R++ K P++K+ E    D F+ N+ F  K I+IKI  + +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+H LLV+E+  QLK  F   P  +K+RIESL+ERDY+ R  +    YHY+A
Sbjct:  374 KFYLAKHSGRKLQWQNTLGHCVVKADFSEVKKE------------------------------------------------LQVSLFQTLVLLMFNEGNEYSLEDIKQATGVEDGELRRTLQSLACGKA--RVIKKRPQSKDIE--DGDIFTFNKEFKHKLIRIKINQVQMKETPEENVNTTERVFQDRQYQIDAAIVRIMKTRKTLSHTLLVSELYTQLK--FPVKPTDLKKRIESLIERDYMERDKEIANQYHYVA 577          
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO37570 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFF7])

HSP 1 Score: 91.6633 bits (226), Expect = 1.289e-18
Identity = 62/180 (34.44%), Postives = 101/180 (56.11%), Query Frame = 1
Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            ++ LQ STYQM +L+ FN    Y+ E++ E+T++    L + L  L  +K    +LL +     +    +    +   + +K +++ I      E   E ++T   ++E+RK +I+A IVRIMK RK L H  L+AEV+ QL SRF P    IK+ I+ L+E++YL R + ++  Y YLA
Sbjct:  594 RYTLQASTYQMGVLLMFNTADSYTVEQIQEQTQLKMELLIQVLGILLKTK----LLLCDTCEDVSGLEPSSVLKLFFGYKNKKLRVNINVPMKTEQRNEQEQTHKYIEEDRKLLIQAAIVRIMKMRKMLKHQPLLAEVLSQLSSRFKPRVPTIKKCIDILIEKEYLERVEGEKDTYAYLA 769          
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO38761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC24])

HSP 1 Score: 83.9593 bits (206), Expect = 2.853e-16
Identity = 62/190 (32.63%), Postives = 105/190 (55.26%), Query Frame = 1
Query: 3913 KFILQVSTYQMIILMKFNRK--SKYSYEELVEETKIPERDLTRCLISL-SLSKSTQRILLKEPKNKN-TEFIATDTFSINESFTS-KHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYV------IEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYL 4449
            KF L+V+T+QM +L  +N +     SYE L   T++P+ +L + L S+ S+ K  ++IL  EP  ++  +F  +  F +N+ F   K+ K++ +         ++   K K +EN   V      I+  IV+IMK RK + +  L  E++E LK+ F+P  +MIK++ E L+E  YL R ++D   + YL
Sbjct:  595 KFDLEVTTFQMSVLFAWNERPLDHISYENLRLATELPDSELRKTLWSMVSIPKLKRQILTCEPAVRSPKDFTDSSMFWVNQDFALIKNGKVQKRGKVNLIGRLQLSTDKAKQEENEGIVALRILRIQEAIVKIMKMRKRITNAALQTELVEILKNMFIPQKKMIKEQTEWLIEHKYLKRDEEDINTFIYL 784          
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO49091 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI48])

HSP 1 Score: 71.2478 bits (173), Expect = 2.231e-12
Identity = 55/188 (29.26%), Postives = 101/188 (53.72%), Query Frame = 1
Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI----AXXXXXXXXXXXXXXXDENRKYVIEATIVR---IMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            R + L VST+QM +++ FN K ++++ EL   T++  ++LTR + SL   K     LL + ++ +++     T+S+N +F+SK  K+KI S     + +             D    ++ E  +VR   + +   +L    L  +VI Q ++RF+P+  MIK+ IE+L+++ YL R +  +  Y Y+A
Sbjct:  569 RTYFLTVSTFQMAVMLLFNDKLQFTFSELSTLTQLLNKELTRIIQSLVDVK-----LLNKTEDDDSK---EATYSLNMNFSSKRTKLKITSAVQRDSPQVVILLSTRGTADSDNWHLHLAEKPMVRSYHLQQTNDTLFSFCL--QVISQSRARFIPSVPMIKKCIEALIDKQYLDRQEGSKDEYSYVA 746          
BLAST of Cullin-3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875])

HSP 1 Score: 207.223 bits (526), Expect = 4.394e-55
Identity = 124/260 (47.69%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G  +L A +       + ++   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN   K+++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  515 RFYLAKHSGRQLTLQHHMGGADLNATF-------YGAVKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746          
BLAST of Cullin-3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875])

HSP 1 Score: 207.608 bits (527), Expect = 4.995e-55
Identity = 124/260 (47.69%), Postives = 174/260 (66.92%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYL KH+GR + LQ ++G  +L A +       + ++   DG SE     G   +Q+ G               + RK ILQVST+QM ILM FN   K+++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E  +   F++N+ FTSK  ++KIQ++A K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  535 RFYLAKHSGRQLTLQHHMGGADLNATF-------YGAVKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766          
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul3b (cullin-3 [Source:NCBI gene;Acc:101172920])

HSP 1 Score: 205.682 bits (522), Expect = 1.552e-54
Identity = 124/260 (47.69%), Postives = 172/260 (66.15%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYLGKH+GR + LQ ++G+ +L A +       +  +   DG           S  +VG  GA     +       RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+  K TQR+L KEPK+K  E      F++N+ FTSK  ++KIQ++  K+ E   E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A
Sbjct:  515 RFYLGKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG-----------SEVVVG--GAQVTGSNT------RKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVVAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746          
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul4a (cullin-4A [Source:NCBI gene;Acc:101154851])

HSP 1 Score: 132.494 bits (332), Expect = 3.261e-31
Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1
Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            FYLGKH+GR +  QP LG+  L A                       F +G +                           LQVS +Q ++L+ FN   ++S EE+   T I E +L R L SL+  K+  R+L K P+ K+ E    D F+ N  F  K  +IKI  I +KET  E   T  +V ++R+Y I+A +VRIMK RK+L+HNLLV+E+  QLK  F   P  +K+RIESL++RDY+ R  +    YHY+A
Sbjct:  410 FYLGKHSGRKLQWQPTLGHAVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSVEEIRAATGIEEGELKRTLQSLACGKA--RVLNKNPRGKDVE--DGDRFNFNSDFKHKLFRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKETPNQYHYVA 612          
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul4b (cullin 4B [Source:NCBI gene;Acc:101161413])

HSP 1 Score: 122.094 bits (305), Expect = 1.176e-27
Identity = 79/177 (44.63%), Postives = 113/177 (63.84%), Query Frame = 1
Query: 3922 LQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            LQVS +Q ++L+ FN   ++S EE+   T I + +L R L SL+  K+  R+L K PK+K+ E    D FS N  F  K  +IKI  I +KET  E   T  +V ++R+Y I+A IVRIMK RK+L+HNLL++EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y+Y+A
Sbjct:  583 LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGKA--RVLTKTPKSKDVE--DGDKFSCNNDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLMSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENSNQYNYVA 753          
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000001134.1 (SMESG000001134.1)

HSP 1 Score: 465.692 bits (1197), Expect = 2.633e-145
Identity = 258/258 (100.00%), Postives = 258/258 (100.00%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452
            RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPEVKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA
Sbjct:  536 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPEVKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 793          
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000040512.1 (SMESG000040512.1)

HSP 1 Score: 234.958 bits (598), Expect = 8.006e-71
Identity = 136/154 (88.31%), Postives = 142/154 (92.21%), Query Frame = 2
Query:  287 RSQLN-QIRNEVYESPVISLGELENWLQSSSSIPELEDEAFVVNYKITYAXXXXXXXXXXXXXXXXXXHGSKFRFFISTIRLLKLASASKILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGLRKINASLF 745
            R+QL  +IRNEVY  PVISLGELENWLQSSSSIPEL+DE FVVNYKITY+ EYECEESNEESDEDEENHG KFRFFISTIRLLKLASAS ILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGL+K    +F
Sbjct:   15 RAQLILEIRNEVYGPPVISLGELENWLQSSSSIPELKDEGFVVNYKITYSYEYECEESNEESDEDEENHGFKFRFFISTIRLLKLASASTILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGLKKNKCIIF 168          
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000033325.1 (SMESG000033325.1)

HSP 1 Score: 168.318 bits (425), Expect = 1.934e-42
Identity = 117/217 (53.92%), Postives = 153/217 (70.51%), Query Frame = 1
Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTF--------QSLTATDGVSEPNF--------NQGYQSSQI--------VGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVI 4257
            +FYL KHNGRVINLQPNLGNVEL+  +  + P++          S + T  + E  F        + G   SQI         G+  +S NS  G TS  I+++ILQVSTYQM+ILMKFN+KSKY+++EL++ET IP+RDLTR L+SLSLSK +QRIL+KEPK+K+T+ + TD F+INESFTSKH KIK+Q+I +KETEPE +ETK +VDENRK  +
Sbjct:  536 KFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNSIPLPLVGSPSSSSTTGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRSLLSLSLSKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNITIKETEPERRETKTRVDENRKLCL 752          
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000026165.1 (SMESG000026165.1)

HSP 1 Score: 88.5817 bits (218), Expect = 9.379e-20
Identity = 49/110 (44.55%), Postives = 69/110 (62.73%), Query Frame = 2
Query:  755 VLISDASNAIRKAYSQVFNKNE-IVMCWAHMRRNCVKKIESLVAKEDQNELIEDVDQLQLSQTKVIFEKASSLFVKKWRQKKATEFLDYMNMMWLTTHNT*YEG---YMP 1072
            VLI+D SNAIR  +S+VF  +  + MCW HMR    KK+  +  K+  +E+++DVD LQLS+ K IF+ A +LF+KKW   K+ E  DY +  WL   +  YEG   Y+P
Sbjct:    7 VLIADGSNAIRNPFSEVFGPDHSMAMCWYHMRERVAKKLCVIDDKDLCSEIMDDVDALQLSKNKPIFDMAVNLFLKKW---KSQERFDYFSREWLGLKSDWYEGLELYVP 113          
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000003282.1 (SMESG000003282.1)

HSP 1 Score: 90.5077 bits (223), Expect = 1.027e-18
Identity = 48/87 (55.17%), Postives = 52/87 (59.77%), Query Frame = 2
Query: 1307 SVPQEQSTNYYVSASD------DIDKVEKMRWTTFDQFTKRAFTVCRINLPNDKANWPTVSAIAQHFLKNLFASMLSAFQSDLNIAK 1549
             + ++QSTNYYVSASD      DIDKVEKM WT FDQFTKRAFTV RINLPNDKANW         F K L    +      L   K
Sbjct:  228 CIDKQQSTNYYVSASDATITQEDIDKVEKMHWTIFDQFTKRAFTVWRINLPNDKANWADGQCNCPAFFKKLICKHVVCISIRLKYCK 314          

HSP 2 Score: 79.7221 bits (195), Expect = 4.056e-15
Identity = 36/45 (80.00%), Postives = 40/45 (88.89%), Query Frame = 1
Query: 1450 SQLADGQCDCPTFFKKFICKHVVGISIRLKYCKVPAVAKNTSIGS 1584
            +  ADGQC+CP FFKK ICKHVV ISIRLKYCKVPA+AKNTSIG+
Sbjct:  282 ANWADGQCNCPAFFKKLICKHVVCISIRLKYCKVPALAKNTSIGN 326          
The following BLAST results are available for this feature:
BLAST of Cullin-3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CUL38.575e-6048.46cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553][more]
CUL36.126e-5648.46cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553][more]
CUL31.199e-5548.46cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553][more]
CUL31.199e-5548.46cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553][more]
CUL31.629e-5548.46cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553][more]
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BLAST of Cullin-3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cul-32.711e-4741.54Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391][more]
cul-32.342e-4240.15Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391][more]
cul-33.262e-4240.93Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391][more]
cul-33.262e-4240.93Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391][more]
cul-33.262e-4240.93Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391][more]
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BLAST of Cullin-3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cul33.613e-5348.06gene:FBgn0261268 transcript:FBtr0302158[more]
Cul33.613e-5348.06gene:FBgn0261268 transcript:FBtr0302157[more]
Cul33.613e-5348.06gene:FBgn0261268 transcript:FBtr0302156[more]
Cul31.336e-5248.06gene:FBgn0261268 transcript:FBtr0302159[more]
Cul49.397e-3036.05gene:FBgn0033260 transcript:FBtr0301355[more]
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BLAST of Cullin-3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cul3a8.954e-5547.31cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376][more]
cul3b1.115e-5347.31cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1][more]
cul4b1.960e-2936.58cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208][more]
cul22.210e-2441.99cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032][more]
cul22.343e-2441.99cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032][more]
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BLAST of Cullin-3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cul31.996e-5648.46cullin 3 [Source:NCBI gene;Acc:548729][more]
cul35.927e-5648.46cullin 3 [Source:NCBI gene;Acc:548729][more]
cul36.142e-5648.46cullin 3 [Source:NCBI gene;Acc:548729][more]
cul36.791e-5648.46cullin 3 [Source:NCBI gene;Acc:548729][more]
cul4a6.294e-3136.58cullin 4A [Source:NCBI gene;Acc:548647][more]
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BLAST of Cullin-3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cul31.484e-5648.46cullin 3 [Source:MGI Symbol;Acc:MGI:1347360][more]
Cul34.530e-5648.46cullin 3 [Source:MGI Symbol;Acc:MGI:1347360][more]
Cul4a1.309e-3036.58cullin 4A [Source:MGI Symbol;Acc:MGI:1914487][more]
Cul4b8.729e-3036.58cullin 4B [Source:MGI Symbol;Acc:MGI:1919834][more]
Cul4b8.729e-3036.58cullin 4B [Source:MGI Symbol;Acc:MGI:1919834][more]
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BLAST of Cullin-3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6GPF3|CUL3B_XENLA1.568e-5548.46Cullin-3-B OS=Xenopus laevis OX=8355 GN=cul3b PE=1... [more]
sp|Q6DE95|CUL3A_XENLA2.946e-5548.46Cullin-3-A OS=Xenopus laevis OX=8355 GN=cul3a PE=1... [more]
sp|A4IHP4|CUL3_XENTR3.140e-5548.46Cullin-3 OS=Xenopus tropicalis OX=8364 GN=cul3 PE=... [more]
sp|Q9JLV5|CUL3_MOUSE3.169e-5548.46Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=... [more]
sp|B5DF89|CUL3_RAT3.227e-5548.46Cullin-3 OS=Rattus norvegicus OX=10116 GN=Cul3 PE=... [more]
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BLAST of Cullin-3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
G4VPI82.110e-6956.15Putative cullin OS=Schistosoma mansoni OX=6183 GN=... [more]
G4VPI97.747e-6855.20Putative cullin OS=Schistosoma mansoni OX=6183 GN=... [more]
A0A5K4F8C91.260e-6754.80Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A183SVC21.307e-6756.02Cullin-3 OS=Schistocephalus solidus OX=70667 GN=SS... [more]
A0A0X3PL621.489e-6756.02Cullin-3 (Fragment) OS=Schistocephalus solidus OX=... [more]
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BLAST of Cullin-3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cul3b8.719e-5546.92cullin 3 [Source:NCBI gene;Acc:103024283][more]
cul3a1.579e-5347.69cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376][more]
cul4a1.096e-3036.19cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357][more]
ENSAMXT00000057183.13.935e-3036.96pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
cul22.551e-2541.44cullin 2 [Source:NCBI gene;Acc:103040496][more]
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BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cul23.721e-2438.38cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032][more]
cul1b5.695e-2136.61cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887][more]
cul1b3.708e-2034.59cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887][more]
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BLAST of Cullin-3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
CUL37.230e-1229.12Ubiquitin-protein ligase; forms a complex with Elc... [more]
CDC532.679e-1047.14Cullin; structural protein of SCF complexes (which... [more]
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BLAST of Cullin-3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO352301.930e-5949.62Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO356603.991e-2833.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO375701.289e-1834.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387612.853e-1632.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490912.231e-1229.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cullin-3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CUL34.394e-5547.69cullin-3-like [Source:NCBI gene;Acc:101170875][more]
CUL34.995e-5547.69cullin-3-like [Source:NCBI gene;Acc:101170875][more]
cul3b1.552e-5447.69cullin-3 [Source:NCBI gene;Acc:101172920][more]
cul4a3.261e-3136.58cullin-4A [Source:NCBI gene;Acc:101154851][more]
cul4b1.176e-2744.63cullin 4B [Source:NCBI gene;Acc:101161413][more]
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BLAST of Cullin-3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000001134.12.633e-145100.00SMESG000001134.1[more]
SMESG000040512.18.006e-7188.31SMESG000040512.1[more]
SMESG000033325.11.934e-4253.92SMESG000033325.1[more]
SMESG000026165.19.379e-2044.55SMESG000026165.1[more]
SMESG000003282.11.027e-1855.17SMESG000003282.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015048 ID=SMED30015048|Name=Cullin-3|organism=Schmidtea mediterranea sexual|type=transcript|length=4621bp
AAAAAGTTTACTATCGATGCAATCAAGTTAAATTTAAAGGCAAGCAATGT
GATTCTGCATTACATTTACTTTACGACTCAAGATCAGACGAAGTTATTCT
TTTTAGGGCAGAAGCTGAGCATAAGCATGAAGAAAACATGTCTAAATCTG
CAATATCTAACGAAGCTAAAGAACTAATTAAAGAGTTGTTTAAGCTTAAA
ATAAAACCTAAGAGAATGTTAGAAATCTTTCATGAACGAGGTATAAAGCC
TGTTCCAGGAACAGTGTTCCTACCACTATACAATTAAGAAGTCAATTAAA
CCAGATTAGAAATGAAGTTTACGAGTCACCAGTAATAAGCTTAGGTGAGC
TTGAAAATTGGCTTCAATCATCATCTTCTATACCAGAGTTAGAAGATGAA
GCCTTTGTAGTCAATTATAAAATAACTTATGCCGATGAATATGAGTGTGA
AGAGAGTAATGAAGAAAGCGATGAAGATGAAGAAAACCACGGCTCTAAAT
TTAGATTTTTTATAAGTACAATAAGATTACTTAAGCTAGCCTCAGCATCA
AAAATTTTAAATGCTGATGCAACTTATAAACTGGTTTGGCAGGGCTATCC
AATTTTAATCATTGGTACAACCGATTTAGATAGGCATTTTCATTCGTTTG
GCCTAGGTATATGTACCAATGAAAAAACTGCTGATTTTAATTTTATTTTT
TCAAGTATCAATATTGGCTTGAGAAAAATAAATGCATCATTATTCAATCC
TCGTGTATTGATTTCTGATGCTTCTAACGCTATACGTAAAGCTTATTCAC
AAGTTTTTAATAAAAATGAAATTGTGATGTGTTGGGCACATATGCGTAGA
AATTGTGTCAAAAAAATCGAGTCTTTAGTAGCTAAAGAAGATCAAAACGA
ATTAATTGAAGATGTAGATCAACTTCAATTGTCACAAACAAAAGTCATTT
TTGAAAAAGCAAGTTCTCTATTTGTTAAGAAATGGAGACAAAAAAAAGCG
ACTGAGTTTTTAGACTATATGAATATGATGTGGCTTACGACACACAATAC
TTGATATGAAGGATACATGCCCTTCACGTCAAGTACTAACAATAATATAG
AGTCAAATAATCGAGTTCTAAAAGACGAAGAAACTATTAGAGAGCGCACG
CCATTATCTAGATTTAGCAAACAAGCTTTAGATATTGTTAAAAAGTGGTC
ACTAGCATATCCTCGAAGTCTGAAGGAGTTTATTACAAAACAATCAATCG
ACACAGCATTATGGACACAGTCTTATCAATGGGCTAAAGAAAGCAAAGCA
ATTCTTTCGGTGCCCCAAGAACAGTCGACAAACTACTATGTTTCAGCTAG
TGACGACATTGACAAAGTTGAAAAAATGCGCTGGACAACATTCGATCAAT
TTACGAAGCGAGCTTTTACTGTCTGTCGCATTAATTTACCAAACGATAAA
GCCAATTGGCCGACGGTCAGTGCGATTGCCCAACATTTTTTAAAAAATTT
ATTTGCAAGCATGTTGTCGGCATTTCAATCAGACTTAAATATTGCAAAGT
ACCGGCTGTAGCTAAGAATACTTCTATTGGAAGTAAACTACCAAGAGGAA
GACCAACTAAAGCTAAAAAAGCCTTATTAAAACAATAATTTCAAATATTT
TTATAATAGTCTTTGTGAAATAGTCTTTGTATTTTTATGGATTTTTTTAT
TGTGTCACTTTTGTTTATTCTTATGAATTTTTCATTGTTTTACTTAGTTT
TTGTATTTTTTTACTTATAAAAATTAAAAATATTACCTATAATAAAATAA
TTAAATACCTAATGAATTCTATTTTTTACTTATACAATTAATATAATACT
TAGCATTTTATAAATATTTACTTAGAAAAAAATACATAAAGGCACTAATA
AAATACATAGCGTTTAGTAAAAAATACATAGCGAATAAATAGGAGCCTTA
AACCAATTATAAAAAAGTTTGTATGTTTAAACAAAGTTCTGTCATTAAGT
TGCTGGAATATATAACTCATTAAAAATACTGATTTCGAAACGATAAAAAC
TAAATTGTAAATCGTTTTAGGAAATTATAAATAAAATTTAAATTTTTGAT
TCGAAAATTAACATAACTTGTTTTTTAAATAATAATTATCATCTTAAATT
AGTTAATTATGAAATGGTGATGTACTCACATGAATAGAAGGGGTATAGCT
CTTTGTTACAAATTTTGACAGTGTTGGAATTTTATGGGGAGGATAACGTG
ATATCGTTTAAAAACCGCTCCACTGCTGTGTTTCTAAGGAGGCATATCAA
GAAGTGATTATATACTGAATTTAATAAGGTAAAGTATAATGTTTATTAAA
TGTAATATATGAAATTTAAATATTCAAGTCTTTGTTTCACTTTTGAAAAT
ATTAAGAAAAGCATAAAAAATTAATCATATTATATTTTTGGAGAAAATCG
TTCAAAAATTTCAATTTATTATTGAATTTTACTATGAATTTATCACCTGA
ATTACTTTTGATAAGTTTTTTTTAAAAGACTGAATAAAAATGACACAGAA
TGAAGTTTAATACCTTTACAAATGTTATTACAATGTTTATAGTAAACAGT
GTTGCCACATATAAGACCATGTTCACTATTGTCAATTAACGTCATATTAT
AATAGATTAAAAATATAAAAAATCAACCTATTTCTGTTAGGTACGTAAAA
TAGTCCGCGAAAATTAGTAAATTCAGAGGTTAAGTTATTTAGGTTATTTT
TAATGAAAGAAAATTTGTAATTCTAATGTTGTACACTGTTATTGGCAAGG
TTCTAGTATATGTACATTAGAATCATCATATATTTAATTACCCGTGCCCA
CATTTATAGCAAGAATTTTAAGGACTTTAATACTAAATGTGTCAAATTTT
GAAAATTTTGAAAATATTTTAAAAAACGATTTTGATGTATTGATTTTTCA
CTATAATTTTGTTTATAACATGTCAGCGAAGTCCGACAATTTTATTCGTG
TAATATTTCACTTTGTTTTCCGGTGAATATTTTTGAATTACTTTTGTATA
AAATAAGTAGATAATTTTTAAACTTGTATTTTATTGATAGACAATAATAT
AATGGAGAATATTTCTGTGTAACAAATAGATTTATTCTGCTGATCATAAT
TAATAGGACGTATTACAAAAAATTGTTTAATAATTTTTTTAATATATGAA
TTTTTGTGCGTAACGCTATTAATTGATTGTACTGACTGAATAATAGAATA
CATACCGAATTTTTCATACGGAATTAAAAGTCTAAAAGAAAAAAAGAATT
TCTTTTACTTATGTCATTTATGACGGCTATACGTAACAGACAAATAAATG
ACGTCACGCGCTTAAAGGTGGGAAGACCACAAAGAGGTGTCTTAGAAATA
TTATATTACATGAAATTGCATCGAACATCAACACGTTCTTAATTTGTTGG
CTCCTTAGTTTGATTATTTCAAATTTTAATTCTTTAAGTAATTGTGAGAT
ATTCAGAATAACTATTAAATGACTGAAAATATTTTATTCTGCTGTATTAT
TCAGAACTATAATGCGTTTGGTTAGGTTTCAGTTTAGAACCATATTTTTT
TCATTTTTATTGCATTTAATATTTGTCTTAAAAAACTTTATATACATTTA
GTCCCTTTTAATTAACATAAATTGTTTAAGATTCTATCTTGGTAAACATA
ATGGAAGAGTAATAAATCTTCAGCCGAATTTGGGAAATGTTGAATTGACG
GCTTATTATATGCAAAGTCAACCATCGACATTTCAATCTTTAACTGCAAC
CGATGGCGTCTCTGAGCCTAACTTTAATCAGGGCTATCAAAGCAGTCAGA
TCGTTGGAGATGTTGGTGCTTCATTTAATTCTTTTTCAGGATCTACTTCT
CAGTCAATCAGAAAATTTATTCTTCAAGTTTCGACTTATCAAATGATCAT
TCTGATGAAATTTAATCGTAAATCCAAATATTCCTATGAAGAATTGGTAG
AGGAGACAAAAATTCCAGAGCGTGATCTTACAAGATGTTTGATCTCTTTA
TCGCTTAGCAAAAGTACGCAGAGAATATTATTAAAGGAACCAAAAAATAA
AAACACTGAATTTATAGCCACAGATACGTTTAGTATCAATGAAAGCTTTA
CATCAAAGCATATCAAAATAAAGATTCAGAGTATTGCTGTTAAGGAAACT
GAACCAGAAGTAAAAGAAACGAAAAACAAAGTTGACGAGAATCGAAAATA
TGTTATTGAAGCTACTATAGTTCGAATAATGAAAGCAAGGAAATCATTAG
CACATAATTTATTGGTGGCGGAGGTTATTGAACAATTAAAATCCAGATTC
GTTCCAACTCCACAGATGATTAAACAGCGGATTGAGTCTTTACTAGAGCG
TGATTATTTAGCTCGATCTGATGATGACAGAAAGGTTTATCATTATCTAG
CTTAGTTGATTTATTTTATTTTAATACAATTTTGAAAAAAATTCGAGTTA
CAAATCTTTTCAATGACGTAGGATATTGTTGATTAATAATCATGTAAGTA
TACCAGCAATTTTACGAAAGATAACTTGTCTGTAATTTATATTATTTTCT
TTTAATAAATTCTGTTCCACA
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protein sequence of SMED30015048-orf-1

>SMED30015048-orf-1 ID=SMED30015048-orf-1|Name=SMED30015048-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=165bp
MPFTSSTNNNIESNNRVLKDEETIRERTPLSRFSKQALDIVKKWSLAYPR
SLKEFITKQSIDTALWTQSYQWAKESKAILSVPQEQSTNYYVSASDDIDK
VEKMRWTTFDQFTKRAFTVCRINLPNDKANWPTVSAIAQHFLKNLFASML
SAFQSDLNIAKYRL*
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protein sequence of SMED30015048-orf-2

>SMED30015048-orf-2 ID=SMED30015048-orf-2|Name=SMED30015048-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=232bp
MQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSI
RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLS
KSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPE
VKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPT
PQMIKQRIESLLERDYLARSDDDRKVYHYLA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000136whole organism
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR036388WH-like_DNA-bd_sf
IPR036317Cullin_homology_sf
IPR036390WH_DNA-bd_sf
IPR019559Cullin_neddylation_domain
IPR001373Cullin_N
IPR011991WHTH_DNA-bd_dom
IPR016157Cullin_CS
IPR016158Cullin_homology
IPR013809ENTH
IPR007527Znf_SWIM
IPR018289MULE_transposase_dom
Vocabulary: molecular function
TermDefinition
GO:0031625ubiquitin protein ligase binding
GO:0008270zinc ion binding
Vocabulary: biological process
TermDefinition
GO:0006511ubiquitin-dependent protein catabolic process
Vocabulary: cellular component
TermDefinition
GO:0031461cullin-RING ubiquitin ligase complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR019559Cullin protein, neddylation domainSMARTSM00884Cullin_Nedd8_2coord: 158..225
e-value: 2.3E-36
score: 136.8
IPR019559Cullin protein, neddylation domainPFAMPF10557Cullin_Nedd8coord: 161..223
e-value: 4.7E-29
score: 100.2
IPR001373Cullin, N-terminalPFAMPF00888Cullincoord: 33..130
e-value: 8.1E-23
score: 80.9
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 144..231
e-value: 8.9E-36
score: 123.7
NoneNo IPR availableGENE3DG3DSA:1.10.10.2620coord: 32..143
e-value: 6.5E-23
score: 83.0
NoneNo IPR availablePANTHERPTHR11932CULLINcoord: 37..231
NoneNo IPR availablePANTHERPTHR11932:SF126CULLIN-3coord: 37..231
IPR016157Cullin, conserved sitePROSITEPS01256CULLIN_1coord: 204..231
IPR016158Cullin homology domainPROSITEPS50069CULLIN_2coord: 33..98
score: 12.951
IPR036317Cullin homology domain superfamilySUPERFAMILYSSF75632Cullin homology domaincoord: 51..143
IPR036390Winged helix DNA-binding domain superfamilySUPERFAMILYSSF46785"Winged helix" DNA-binding domaincoord: 142..231