Cullin-3
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30015048 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]) HSP 1 Score: 211.075 bits (536), Expect = 8.575e-60 Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 111 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 342
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]) HSP 1 Score: 209.92 bits (533), Expect = 6.126e-56 Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]) HSP 1 Score: 209.92 bits (533), Expect = 1.199e-55 Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 513 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]) HSP 1 Score: 209.92 bits (533), Expect = 1.199e-55 Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 513 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744
BLAST of Cullin-3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]) HSP 1 Score: 209.92 bits (533), Expect = 1.629e-55 Identity = 126/260 (48.46%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]) HSP 1 Score: 170.244 bits (430), Expect = 2.711e-47 Identity = 108/260 (41.54%), Postives = 167/260 (64.23%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFI-ATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++Y KH GR + + LGN ++ A + P S++ + P+ S + + + ILQV+T+QMIIL++FN ++ S ++L++E KIPER+L R L SL+L K++QRIL++ KNK + I +D F++N++F SK ++K+Q + E+EPE++ET+ KV+++RK +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A Sbjct: 4 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVR--KNKGKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 240
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]) HSP 1 Score: 167.548 bits (423), Expect = 2.342e-42 Identity = 104/259 (40.15%), Postives = 163/259 (62.93%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++Y KH GR + + LGN ++ A + ++ + G S + + + ILQV+T+QMIIL++FN ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+ +D F++N++F SK ++K+Q + E+EPE++ET+ KV+++RK +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A Sbjct: 481 QYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKERKPE---------------------HKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 717
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]) HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42 Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++Y KH GR + + LGN ++ A + P S++ + P+ S + + + ILQV+T+QMIIL++FN ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+ +D F++N++F SK ++K+Q + E+EPE++ET+ KV+++RK +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A Sbjct: 541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]) HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42 Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++Y KH GR + + LGN ++ A + P S++ + P+ S + + + ILQV+T+QMIIL++FN ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+ +D F++N++F SK ++K+Q + E+EPE++ET+ KV+++RK +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A Sbjct: 541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777
BLAST of Cullin-3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]) HSP 1 Score: 167.933 bits (424), Expect = 3.262e-42 Identity = 106/259 (40.93%), Postives = 166/259 (64.09%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++Y KH GR + + LGN ++ A + P S++ + P+ S + + + ILQV+T+QMIIL++FN ++ S ++L++E KIPER+L R L SL+L K++QRIL+++ K K+ +D F++N++F SK ++K+Q + E+EPE++ET+ KV+++RK +EA IVRIMKARK L HN LVAEV +QL+ RF+P+P +IKQRIE+L+ER+YLAR + D + Y Y+A Sbjct: 541 QYYTEKHTGRKLTINTLLGNADVKATFY---PPPKASMSNEENGPGPS-----SSGESMKERKPEHK-------------ILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302158) HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53 Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR + LQP +G TAY + F A + SE + + SS G + RK ILQVSTYQM +L+ FN + +Y+++ +ET IPER+L R L SLS+ K QR+L++ K K + TD F +N++F SK ++KIQ++A K E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V QLKSRF+P+P IK+RIE L+ER+YL RS +DRKVY+YLA Sbjct: 538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302157) HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53 Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR + LQP +G TAY + F A + SE + + SS G + RK ILQVSTYQM +L+ FN + +Y+++ +ET IPER+L R L SLS+ K QR+L++ K K + TD F +N++F SK ++KIQ++A K E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V QLKSRF+P+P IK+RIE L+ER+YL RS +DRKVY+YLA Sbjct: 538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302156) HSP 1 Score: 201.83 bits (512), Expect = 3.613e-53 Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR + LQP +G TAY + F A + SE + + SS G + RK ILQVSTYQM +L+ FN + +Y+++ +ET IPER+L R L SLS+ K QR+L++ K K + TD F +N++F SK ++KIQ++A K E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V QLKSRF+P+P IK+RIE L+ER+YL RS +DRKVY+YLA Sbjct: 538 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302159) HSP 1 Score: 202.216 bits (513), Expect = 1.336e-52 Identity = 124/258 (48.06%), Postives = 165/258 (63.95%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX-XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR + LQP +G TAY + F A + SE + + SS G + RK ILQVSTYQM +L+ FN + +Y+++ +ET IPER+L R L SLS+ K QR+L++ K K + TD F +N++F SK ++KIQ++A K E KET+ KVDE+RK+ IEA IVRIMKARK LAHNLLV++V QLKSRF+P+P IK+RIE L+ER+YL RS +DRKVY+YLA Sbjct: 699 FYLNKHSGRQLTLQPQMG----TAYI----NAVFYGRKAVE--SEKDKDAPSSSSSGCG------------VPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934
BLAST of Cullin-3 vs. Ensembl Fly
Match: Cul4 (gene:FBgn0033260 transcript:FBtr0301355) HSP 1 Score: 129.028 bits (323), Expect = 9.397e-30 Identity = 93/258 (36.05%), Postives = 134/258 (51.94%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 +FYL KH+GR + QP LGN L A + D G L VS +Q ++L+ FN K SYEE++ T I + +L R L SL+ ++ R++ K PK + E + D F N FT+K +IKI I +KET E K T+ +V ++R+Y I+A IVRIMK RK+L+HNLL+ E+ QL F P +K+RIESL++RDY+ R D++ Y+Y+A Sbjct: 618 KFYLEKHSGRKLQWQPTLGNCMLRAQF---------------------------------DAGPKE---------------LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRA--RVITKTPKGR--EILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLT--FPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376]) HSP 1 Score: 207.223 bits (526), Expect = 8.954e-55 Identity = 123/260 (47.31%), Postives = 172/260 (66.15%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG VG GA + RK ILQVST+QM ILM FN + K+++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 543 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDGSD-------------VGVGGALLTGSNT------RKHILQVSTFQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul3b (cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1]) HSP 1 Score: 203.756 bits (517), Expect = 1.115e-53 Identity = 123/260 (47.31%), Postives = 172/260 (66.15%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG S +VG GA + RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTS+ ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 536 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG------------SDMVG--GAQVTGSNT------RKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSRLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]) HSP 1 Score: 128.642 bits (322), Expect = 1.960e-29 Identity = 94/257 (36.58%), Postives = 134/257 (52.14%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A F +G + LQVS +Q ++L+ FN ++S E++ T I + +L R L SL+ K+ R+L K PK+K+ E D FS N+ F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV QLK F P +K+RIESL++RDY+ R ++ Y+Y+A Sbjct: 662 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGKA--RVLTKIPKSKDVE--DGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 864
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032]) HSP 1 Score: 111.694 bits (278), Expect = 2.210e-24 Identity = 76/181 (41.99%), Postives = 110/181 (60.77%), Query Frame = 1 Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 + ++ V+TYQM +L+ FN SY+EL + T++ E++L + + SL K L KE E TFS+ SFTSK K KI + K+T E+++T++ VDE+RK ++A IVRIMKARK L HN L+ EVI Q K+RF P+ MIK+ IE L+++ Y+ RS Y Y+A Sbjct: 571 KPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKE------EIEPESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA 745
BLAST of Cullin-3 vs. Ensembl Zebrafish
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032]) HSP 1 Score: 111.694 bits (278), Expect = 2.343e-24 Identity = 76/181 (41.99%), Postives = 110/181 (60.77%), Query Frame = 1 Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 + ++ V+TYQM +L+ FN SY+EL + T++ E++L + + SL K L KE E TFS+ SFTSK K KI + K+T E+++T++ VDE+RK ++A IVRIMKARK L HN L+ EVI Q K+RF P+ MIK+ IE L+++ Y+ RS Y Y+A Sbjct: 584 KPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKE------EIEPESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA 758
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729]) HSP 1 Score: 211.46 bits (537), Expect = 1.996e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729]) HSP 1 Score: 211.075 bits (536), Expect = 5.927e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729]) HSP 1 Score: 211.075 bits (536), Expect = 6.142e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 539 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729]) HSP 1 Score: 211.075 bits (536), Expect = 6.791e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 539 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770
BLAST of Cullin-3 vs. Ensembl Xenopus
Match: cul4a (cullin 4A [Source:NCBI gene;Acc:548647]) HSP 1 Score: 132.88 bits (333), Expect = 6.294e-31 Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A + + + LQVS +Q ++L+ FN+ ++ +EE+ T I + +L R L SL+ K+ R+L K PK+K+ E D F N F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L HNLLV+E+ QLK F P +K+RIESL++RDY+ R D+ K YHYLA Sbjct: 502 FYLGKHSGRRLQWQSTLGHAVLKADFKEEKKE------------------------------------------------LQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKA--RVLNKSPKSKDVE--DGDRFCFNADFKHKLYRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLTHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA 704
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360]) HSP 1 Score: 211.46 bits (537), Expect = 1.484e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 471 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360]) HSP 1 Score: 211.075 bits (536), Expect = 4.530e-56 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4a (cullin 4A [Source:MGI Symbol;Acc:MGI:1914487]) HSP 1 Score: 132.109 bits (331), Expect = 1.309e-30 Identity = 94/257 (36.58%), Postives = 129/257 (50.19%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A +F +G + QVS +Q ++L+ FN +S+EE+ T I + +L R L SL+ K+ R+L+K PK K E D F N F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L HNLLV+E+ QLK F P +K+RIESL++RDY+ R D YHY+A Sbjct: 557 FYLGKHSGRKLQWQTTLGHAVLKA----------------------DFKEGKKE--------------------------FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVE--DGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834]) HSP 1 Score: 130.183 bits (326), Expect = 8.729e-30 Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A F +G + LQVS +Q ++L+ FN ++S EE+ T I + +L R L SL+ K+ R+L K PK K+ E D F N+ F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV QLK F P +K+RIESL++RDY+ R ++ Y+Y+A Sbjct: 768 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIE--DGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970
BLAST of Cullin-3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834]) HSP 1 Score: 130.183 bits (326), Expect = 8.729e-30 Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A F +G + LQVS +Q ++L+ FN ++S EE+ T I + +L R L SL+ K+ R+L K PK K+ E D F N+ F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV QLK F P +K+RIESL++RDY+ R ++ Y+Y+A Sbjct: 768 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGKDIE--DGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q6GPF3|CUL3B_XENLA (Cullin-3-B OS=Xenopus laevis OX=8355 GN=cul3b PE=1 SV=1) HSP 1 Score: 211.846 bits (538), Expect = 1.568e-55 Identity = 126/260 (48.46%), Postives = 176/260 (67.69%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + ++ DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGAVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q6DE95|CUL3A_XENLA (Cullin-3-A OS=Xenopus laevis OX=8355 GN=cul3a PE=1 SV=1) HSP 1 Score: 211.075 bits (536), Expect = 2.946e-55 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNRDKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|A4IHP4|CUL3_XENTR (Cullin-3 OS=Xenopus tropicalis OX=8364 GN=cul3 PE=2 SV=1) HSP 1 Score: 211.075 bits (536), Expect = 3.140e-55 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|Q9JLV5|CUL3_MOUSE (Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=1) HSP 1 Score: 211.075 bits (536), Expect = 3.169e-55 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. UniProt/SwissProt
Match: sp|B5DF89|CUL3_RAT (Cullin-3 OS=Rattus norvegicus OX=10116 GN=Cul3 PE=1 SV=2) HSP 1 Score: 211.075 bits (536), Expect = 3.227e-55 Identity = 126/260 (48.46%), Postives = 175/260 (67.31%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + KY++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QLK+RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPVKKEDG-SEV----GVGGAQVTGS--------------NTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
BLAST of Cullin-3 vs. TrEMBL
Match: G4VPI8 (Putative cullin OS=Schistosoma mansoni OX=6183 GN=Smp_031000.3 PE=3 SV=1) HSP 1 Score: 261.151 bits (666), Expect = 2.110e-69 Identity = 146/260 (56.15%), Postives = 185/260 (71.15%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVS---EPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KHNGR INLQ N+G EL+A + P ++L + +S PN +RK+ LQVSTYQMIILMKFNR+++YS+ EL ET IPER+L R L++L+L + +QRIL KEPK ++ E +TD F +N+SF SKHIK+++QSI VKE+EPE +ET+ KVDENR+YVIEATIVR+MKARK+L+H LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA Sbjct: 537 FYLSKHNGRKINLQTNMGYAELSAVFYGRSPGAPKTLDPPNLISTSSRPN----------------------------VRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 766
BLAST of Cullin-3 vs. TrEMBL
Match: G4VPI9 (Putative cullin OS=Schistosoma mansoni OX=6183 GN=Smp_031000.2 PE=3 SV=1) HSP 1 Score: 257.299 bits (656), Expect = 7.747e-68 Identity = 154/279 (55.20%), Postives = 198/279 (70.97%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYM---QSQPSTFQSLTATD---------GVSEPN--FNQGYQSSQIVGDVGAXXXXXX--------XXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KHNGR INLQ N+G EL+A + + +T Q + TD G S N +Q Q + I G G+ + S+ ++RK+ LQVSTYQMIILMKFNR+++YS+ EL ET IPER+L R L++L+L + +QRIL KEPK ++ E +TD F +N+SF SKHIK+++QSI VKE+EPE +ET+ KVDENR+YVIEATIVR+MKARK+L+H LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA Sbjct: 537 FYLSKHNGRKINLQTNMGYAELSAVFYGRPNADINTPQISSVTDSHIHSFLIHGSSSSNQVTSQSSQQTPISGLPGSPGAPKTLDPPNLISTSSRPNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 813
BLAST of Cullin-3 vs. TrEMBL
Match: A0A5K4F8C9 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 256.914 bits (655), Expect = 1.260e-67 Identity = 154/281 (54.80%), Postives = 198/281 (70.46%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYM---QSQPSTFQSLTATD---------GVSEPNFNQGYQS-------SQIVGDVGAXXX-----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KHNGR INLQ N+G EL+A + + ST Q + TD G S + NQ S + G GA + S S ++ ++RK+ LQVSTYQMIILMKFNR+++YS+ EL ET IPER+L R L++L+L + +QRIL KEPK ++ E +TD F +N+SF SKHIK+++Q I VKE+EPE +ET+ KVDENR+YVIEATI+R+MKARK+L+H LV EVIEQLKSRFVPTP MIKQRIESL+ER++LAR +DDR+VY YLA Sbjct: 537 FYLSKHNGRKINLQTNMGYAELSAVFYGRPNADISTPQISSVTDSHTHGFLIHGSSSASLNQMTSQSSQQSPISGLPGSPGAPKSLDPPNSISTTSRSNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTRDIE--STDVFYVNDSFVSKHIKVRVQGITVKESEPERQETRTKVDENRRYVIEATIMRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 815
BLAST of Cullin-3 vs. TrEMBL
Match: A0A183SVC2 (Cullin-3 OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS8170 PE=3 SV=1) HSP 1 Score: 256.529 bits (654), Expect = 1.307e-67 Identity = 149/266 (56.02%), Postives = 198/266 (74.44%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTA-YYMQSQPSTFQSLT----ATDGVSEPNFNQGYQSSQIVGDVGAXXX----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR I+L NLG+ EL+A ++ S ST Q A G S + + S + G G S S + ++ + RK+ILQVSTYQM+ILM FNR++++++ EL+ +T IPERDL R L++LSLS+STQRIL KEPK+K EF TD F++N++FTS+H K+K+Q+IAV+E+EPE +ET+ ++DENR+YVIEATIVRIMK RK+L HN L+AEVIEQLKSRF PTP IKQRIE+L+ER+++ARSD DRKVY YLA Sbjct: 533 FYLSKHSGRKISLHTNLGHAELSALFFGNSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQASASRANARKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 796
BLAST of Cullin-3 vs. TrEMBL
Match: A0A0X3PL62 (Cullin-3 (Fragment) OS=Schistocephalus solidus OX=70667 GN=CUL3 PE=3 SV=1) HSP 1 Score: 256.144 bits (653), Expect = 1.489e-67 Identity = 149/266 (56.02%), Postives = 198/266 (74.44%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTA-YYMQSQPSTFQSLT----ATDGVSEPNFNQGYQSSQIVGDVGAXXX----XXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYL KH+GR I+L NLG+ EL+A ++ S ST Q A G S + + S + G G S S + ++ + RK+ILQVSTYQM+ILM FNR++++++ EL+ +T IPERDL R L++LSLS+STQRIL KEPK+K EF TD F++N++FTS+H K+K+Q+IAV+E+EPE +ET+ ++DENR+YVIEATIVRIMK RK+L HN L+AEVIEQLKSRF PTP IKQRIE+L+ER+++ARSD DRKVY YLA Sbjct: 538 FYLSKHSGRKISLHTNLGHAELSALFFGNSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQASASRANARKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 801
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul3b (cullin 3 [Source:NCBI gene;Acc:103024283]) HSP 1 Score: 206.838 bits (525), Expect = 8.719e-55 Identity = 122/260 (46.92%), Postives = 173/260 (66.54%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + ++ DG + G +Q+ G + RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 536 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGAIKKEDGS-----DIGVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 767
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376]) HSP 1 Score: 204.527 bits (519), Expect = 1.579e-53 Identity = 124/260 (47.69%), Postives = 172/260 (66.15%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G+ +L A + + + DG SE G +Q+ G + RK ILQVST+QM ILM FN + K +EE+ +ET IPER+L R L SL+ K+TQR+L KEPK+K E F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL+ RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 655 RFYLAKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKCVFEEIQQETDIPERELVRALQSLACGKTTQRVLTKEPKSKEIE--NGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRVRFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 886
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul4a (cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357]) HSP 1 Score: 130.568 bits (327), Expect = 1.096e-30 Identity = 93/257 (36.19%), Postives = 132/257 (51.36%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + QP LG+ L A F +G + LQVS +Q ++L+ FN +++ EE+ T I E +L R L SL+ K+ R+L K P+ K+ E D F+ N F K +IKI I +KET E T +V ++R+Y I+A +VRIMK RK+L+HNLLV+E+ QLK F P +K+RIESL++RDY+ R + YHY+A Sbjct: 410 FYLGKHSGRKLQWQPTLGHAVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFTLEEIQTATGIEEGELKRTLQSLACGKA--RVLNKNPRGKDVE--DGDRFNFNIDFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKESPNQYHYVA 612
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: ENSAMXT00000057183.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001049.1:257741:270576:1 gene:ENSAMXG00000034138.1 transcript:ENSAMXT00000057183.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 129.028 bits (323), Expect = 3.935e-30 Identity = 95/257 (36.96%), Postives = 134/257 (52.14%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + Q LG+ L A F +G + LQVS +Q ++L+ FN ++S EE+ T I + +L R L SL+ K+ R+L K PK+K+ E D FS N+ F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L+HNLLV+EV QLK F P +K+RIESL++RDY+ R ++ Y+Y+A Sbjct: 433 FYLGKHSGRKLQWQSTLGHCVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGKA--RVLTKIPKSKDVE--DGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 635
BLAST of Cullin-3 vs. Ensembl Cavefish
Match: cul2 (cullin 2 [Source:NCBI gene;Acc:103040496]) HSP 1 Score: 114.775 bits (286), Expect = 2.551e-25 Identity = 75/181 (41.44%), Postives = 110/181 (60.77%), Query Frame = 1 Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 + ++ V+TYQM +L+ FN Y+EL + T++ E++L + + SL K KE E A TFS+N SFTSK K KI + ++T E+++T++ VDE+RK ++A IVRIMKARK L HN L+ EVI Q K+RF P+ MIK+ IE L+++ Y+ RS Y Y+A Sbjct: 571 KPYVAMVTTYQMAVLLAFNNSETVGYKELQDSTQMSEKELQKTIKSLLDVKMINHDSQKE------EIEAESTFSLNMSFTSKRTKFKITTSMQRDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKILRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQTSADEYSYVA 745
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032]) HSP 1 Score: 108.612 bits (270), Expect = 3.721e-24 Identity = 71/185 (38.38%), Postives = 110/185 (59.46%), Query Frame = 1 Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLT---RCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQS-IAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 + ++ V+TYQM +L+ FN + +Y EL T++ ER+L R LI + L S+ K E FS+N F+SK K KI S + + EV++T++ VDE+RK ++A IVRIMK+RK L HN L+ EVI Q ++RF+P+ MIK+ IE L+++ Y+ R+ + Y+Y+A Sbjct: 569 KPYVATVTTYQMGVLLAFNGAEQVTYRELEYSTQLNERELVKTIRSLIDVKLVNSS---------GKEDEITPECIFSLNMEFSSKRTKFKITSAMQKDTPQQEVEQTRSAVDEDRKMYLKAAIVRIMKSRKVLKHNALIQEVISQSRARFIPSVSMIKKCIEDLIDKQYIERNQNSTDEYNYVA 744
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887]) HSP 1 Score: 98.5969 bits (244), Expect = 5.695e-21 Identity = 67/183 (36.61%), Postives = 107/183 (58.47%), Query Frame = 1 Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESF---TSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++ LQ ST+QM +L+++N + Y+ ++L E T+I L + L L SK +L+ E +N N + + ++ F +K +++ I E + E + T ++E+RK VI+A IVRIMK RK L H L+AEV+ QL SRF P +IK+ I+ L+E++YL R D ++ Y YLA Sbjct: 597 RYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMDILVQVLQILLKSK----LLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 775
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887]) HSP 1 Score: 95.9005 bits (237), Expect = 3.708e-20 Identity = 64/185 (34.59%), Postives = 109/185 (58.92%), Query Frame = 1 Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEET--KIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESF---TSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++ LQ ST+QM +L+++N + Y+ ++L E T K+ +D+ ++ + L ++L+ E +N N + + ++ F +K +++ I E + E + T ++E+RK VI+A IVRIMK RK L H L+AEV+ QL SRF P +IK+ I+ L+E++YL R D ++ Y YLA Sbjct: 556 RYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMKTKDILVQVLQILLKS---KLLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 737
BLAST of Cullin-3 vs. Ensembl Yeast
Match: CUL3 (Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 [Source:SGD;Acc:S000003235]) HSP 1 Score: 68.1662 bits (165), Expect = 7.230e-12 Identity = 53/182 (29.12%), Postives = 90/182 (49.45%), Query Frame = 1 Query: 3922 LQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAX-----XXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 + S Y +I + F + + E+ E T IP D+ ++S+S + +IL K + N +F S+N F+S + K+K+ IA K + + D + A IVRIMK L+H L+ ++ +SR TP ++K+ I+ L+E++Y+ R+ DD YHYL+ Sbjct: 570 ISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMS-TIPRCKILKKSSSSGNMKF------SVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS 744
BLAST of Cullin-3 vs. Ensembl Yeast
Match: CDC53 (Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant [Source:SGD;Acc:S000002290]) HSP 1 Score: 63.1586 bits (152), Expect = 2.679e-10 Identity = 33/70 (47.14%), Postives = 44/70 (62.86%), Query Frame = 1 Query: 4243 RKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 R+ +EA IVRIMKA+++L H LV E I Q RF M+K+ I+SL+++ YL R DD Y YLA Sbjct: 747 RQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGES-YAYLA 815
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO35230 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM65]) HSP 1 Score: 218.009 bits (554), Expect = 1.930e-59 Identity = 131/264 (49.62%), Postives = 171/264 (64.77%), Query Frame = 1 Query: 3667 INCL-RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI-AXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 +C RFYLG H+GR + LQP LG EL A + P +G Q RK I Q+S+YQM ILM FN + +++YE+++++T IPERDL R L SL+ K+TQR+L KEPK K+ ATD FS+N+ FTSK ++KIQ++ A E+EPE KET+ KVDE+RK+ IEA IVRIMKARK HNLLVAEV EQLK+RF+P+PQ+IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 471 FDCFKRFYLGNHSGRQLTLQPQLGTAELNATF------------------PPVKKEGASLGQ--------------------RKHIFQMSSYQMCILMLFNSQERWTYEDILQQTLIPERDLNRALQSLACGKATQRVLSKEPKGKD--ITATDVFSVNDLFTSKLHRVKIQTVLAKGESEPERKETRTKVDEDRKHEIEAAIVRIMKARKKRPHNLLVAEVTEQLKARFLPSPQVIKKRIEGLIEREYLARTPEDRKVYLYVA 694
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO35660 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKY8]) HSP 1 Score: 120.939 bits (302), Expect = 3.991e-28 Identity = 87/258 (33.72%), Postives = 134/258 (51.94%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 +FYL KH+GR + Q LG+ + A + + + LQVS +Q ++L+ FN ++YS E++ + T + + +L R L SL+ K+ R++ K P++K+ E D F+ N+ F K I+IKI + +KET E T +V ++R+Y I+A IVRIMK RK+L+H LLV+E+ QLK F P +K+RIESL+ERDY+ R + YHY+A Sbjct: 374 KFYLAKHSGRKLQWQNTLGHCVVKADFSEVKKE------------------------------------------------LQVSLFQTLVLLMFNEGNEYSLEDIKQATGVEDGELRRTLQSLACGKA--RVIKKRPQSKDIE--DGDIFTFNKEFKHKLIRIKINQVQMKETPEENVNTTERVFQDRQYQIDAAIVRIMKTRKTLSHTLLVSELYTQLK--FPVKPTDLKKRIESLIERDYMERDKEIANQYHYVA 577
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO37570 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFF7]) HSP 1 Score: 91.6633 bits (226), Expect = 1.289e-18 Identity = 62/180 (34.44%), Postives = 101/180 (56.11%), Query Frame = 1 Query: 3913 KFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 ++ LQ STYQM +L+ FN Y+ E++ E+T++ L + L L +K +LL + + + + + +K +++ I E E ++T ++E+RK +I+A IVRIMK RK L H L+AEV+ QL SRF P IK+ I+ L+E++YL R + ++ Y YLA Sbjct: 594 RYTLQASTYQMGVLLMFNTADSYTVEQIQEQTQLKMELLIQVLGILLKTK----LLLCDTCEDVSGLEPSSVLKLFFGYKNKKLRVNINVPMKTEQRNEQEQTHKYIEEDRKLLIQAAIVRIMKMRKMLKHQPLLAEVLSQLSSRFKPRVPTIKKCIDILIEKEYLERVEGEKDTYAYLA 769
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO38761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC24]) HSP 1 Score: 83.9593 bits (206), Expect = 2.853e-16 Identity = 62/190 (32.63%), Postives = 105/190 (55.26%), Query Frame = 1 Query: 3913 KFILQVSTYQMIILMKFNRK--SKYSYEELVEETKIPERDLTRCLISL-SLSKSTQRILLKEPKNKN-TEFIATDTFSINESFTS-KHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYV------IEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYL 4449 KF L+V+T+QM +L +N + SYE L T++P+ +L + L S+ S+ K ++IL EP ++ +F + F +N+ F K+ K++ + ++ K K +EN V I+ IV+IMK RK + + L E++E LK+ F+P +MIK++ E L+E YL R ++D + YL Sbjct: 595 KFDLEVTTFQMSVLFAWNERPLDHISYENLRLATELPDSELRKTLWSMVSIPKLKRQILTCEPAVRSPKDFTDSSMFWVNQDFALIKNGKVQKRGKVNLIGRLQLSTDKAKQEENEGIVALRILRIQEAIVKIMKMRKRITNAALQTELVEILKNMFIPQKKMIKEQTEWLIEHKYLKRDEEDINTFIYL 784
BLAST of Cullin-3 vs. Ensembl Nematostella
Match: EDO49091 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI48]) HSP 1 Score: 71.2478 bits (173), Expect = 2.231e-12 Identity = 55/188 (29.26%), Postives = 101/188 (53.72%), Query Frame = 1 Query: 3910 RKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSI----AXXXXXXXXXXXXXXXDENRKYVIEATIVR---IMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 R + L VST+QM +++ FN K ++++ EL T++ ++LTR + SL K LL + ++ +++ T+S+N +F+SK K+KI S + + D ++ E +VR + + +L L +VI Q ++RF+P+ MIK+ IE+L+++ YL R + + Y Y+A Sbjct: 569 RTYFLTVSTFQMAVMLLFNDKLQFTFSELSTLTQLLNKELTRIIQSLVDVK-----LLNKTEDDDSK---EATYSLNMNFSSKRTKLKITSAVQRDSPQVVILLSTRGTADSDNWHLHLAEKPMVRSYHLQQTNDTLFSFCL--QVISQSRARFIPSVPMIKKCIEALIDKQYLDRQEGSKDEYSYVA 746
BLAST of Cullin-3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875]) HSP 1 Score: 207.223 bits (526), Expect = 4.394e-55 Identity = 124/260 (47.69%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G +L A + + ++ DG SE G +Q+ G + RK ILQVST+QM ILM FN K+++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 515 RFYLAKHSGRQLTLQHHMGGADLNATF-------YGAVKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746
BLAST of Cullin-3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875]) HSP 1 Score: 207.608 bits (527), Expect = 4.995e-55 Identity = 124/260 (47.69%), Postives = 174/260 (66.92%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYL KH+GR + LQ ++G +L A + + ++ DG SE G +Q+ G + RK ILQVST+QM ILM FN K+++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E + F++N+ FTSK ++KIQ++A K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 535 RFYLAKHSGRQLTLQHHMGGADLNATF-------YGAVKKEDG-SEV----GVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul3b (cullin-3 [Source:NCBI gene;Acc:101172920]) HSP 1 Score: 205.682 bits (522), Expect = 1.552e-54 Identity = 124/260 (47.69%), Postives = 172/260 (66.15%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXX--XXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYLGKH+GR + LQ ++G+ +L A + + + DG S +VG GA + RK ILQVST+QM ILM FN + K ++EE+ +ET IPER+L R L SL+ K TQR+L KEPK+K E F++N+ FTSK ++KIQ++ K+ E E KET+ KVD++RK+ IEA IVRIMK+RK + HN+LVAEV +QL++RF+P+P +IK+RIE L+ER+YLAR+ +DRKVY Y+A Sbjct: 515 RFYLGKHSGRQLTLQHHMGSADLNATF-------YGPIKKEDG-----------SEVVVG--GAQVTGSNT------RKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVVAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul4a (cullin-4A [Source:NCBI gene;Acc:101154851]) HSP 1 Score: 132.494 bits (332), Expect = 3.261e-31 Identity = 94/257 (36.58%), Postives = 132/257 (51.36%), Query Frame = 1 Query: 3682 FYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 FYLGKH+GR + QP LG+ L A F +G + LQVS +Q ++L+ FN ++S EE+ T I E +L R L SL+ K+ R+L K P+ K+ E D F+ N F K +IKI I +KET E T +V ++R+Y I+A +VRIMK RK+L+HNLLV+E+ QLK F P +K+RIESL++RDY+ R + YHY+A Sbjct: 410 FYLGKHSGRKLQWQPTLGHAVLKA----------------------EFKEGKKE--------------------------LQVSLFQTLVLLMFNEGEEFSVEEIRAATGIEEGELKRTLQSLACGKA--RVLNKNPRGKDVE--DGDRFNFNSDFKHKLFRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKETPNQYHYVA 612
BLAST of Cullin-3 vs. Ensembl Medaka
Match: cul4b (cullin 4B [Source:NCBI gene;Acc:101161413]) HSP 1 Score: 122.094 bits (305), Expect = 1.176e-27 Identity = 79/177 (44.63%), Postives = 113/177 (63.84%), Query Frame = 1 Query: 3922 LQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 LQVS +Q ++L+ FN ++S EE+ T I + +L R L SL+ K+ R+L K PK+K+ E D FS N F K +IKI I +KET E T +V ++R+Y I+A IVRIMK RK+L+HNLL++EV QLK F P +K+RIESL++RDY+ R ++ Y+Y+A Sbjct: 583 LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGKA--RVLTKTPKSKDVE--DGDKFSCNNDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLMSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENSNQYNYVA 753
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000001134.1 (SMESG000001134.1) HSP 1 Score: 465.692 bits (1197), Expect = 2.633e-145 Identity = 258/258 (100.00%), Postives = 258/258 (100.00%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 4452 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPEVKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA Sbjct: 536 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPEVKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 793
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000040512.1 (SMESG000040512.1) HSP 1 Score: 234.958 bits (598), Expect = 8.006e-71 Identity = 136/154 (88.31%), Postives = 142/154 (92.21%), Query Frame = 2 Query: 287 RSQLN-QIRNEVYESPVISLGELENWLQSSSSIPELEDEAFVVNYKITYAXXXXXXXXXXXXXXXXXXHGSKFRFFISTIRLLKLASASKILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGLRKINASLF 745 R+QL +IRNEVY PVISLGELENWLQSSSSIPEL+DE FVVNYKITY+ EYECEESNEESDEDEENHG KFRFFISTIRLLKLASAS ILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGL+K +F Sbjct: 15 RAQLILEIRNEVYGPPVISLGELENWLQSSSSIPELKDEGFVVNYKITYSYEYECEESNEESDEDEENHGFKFRFFISTIRLLKLASASTILNADATYKLVWQGYPILIIGTTDLDRHFHSFGLGICTNEKTADFNFIFSSINIGLKKNKCIIF 168
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000033325.1 (SMESG000033325.1) HSP 1 Score: 168.318 bits (425), Expect = 1.934e-42 Identity = 117/217 (53.92%), Postives = 153/217 (70.51%), Query Frame = 1 Query: 3679 RFYLGKHNGRVINLQPNLGNVELTAYYMQSQPSTF--------QSLTATDGVSEPNF--------NQGYQSSQI--------VGDVGAXXXXXXXXXXXXIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAXXXXXXXXXXXXXXXDENRKYVI 4257 +FYL KHNGRVINLQPNLGNVEL+ + + P++ S + T + E F + G SQI G+ +S NS G TS I+++ILQVSTYQM+ILMKFN+KSKY+++EL++ET IP+RDLTR L+SLSLSK +QRIL+KEPK+K+T+ + TD F+INESFTSKH KIK+Q+I +KETEPE +ETK +VDENRK + Sbjct: 536 KFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNSIPLPLVGSPSSSSTTGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRSLLSLSLSKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNITIKETEPERRETKTRVDENRKLCL 752
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000026165.1 (SMESG000026165.1) HSP 1 Score: 88.5817 bits (218), Expect = 9.379e-20 Identity = 49/110 (44.55%), Postives = 69/110 (62.73%), Query Frame = 2 Query: 755 VLISDASNAIRKAYSQVFNKNE-IVMCWAHMRRNCVKKIESLVAKEDQNELIEDVDQLQLSQTKVIFEKASSLFVKKWRQKKATEFLDYMNMMWLTTHNT*YEG---YMP 1072 VLI+D SNAIR +S+VF + + MCW HMR KK+ + K+ +E+++DVD LQLS+ K IF+ A +LF+KKW K+ E DY + WL + YEG Y+P Sbjct: 7 VLIADGSNAIRNPFSEVFGPDHSMAMCWYHMRERVAKKLCVIDDKDLCSEIMDDVDALQLSKNKPIFDMAVNLFLKKW---KSQERFDYFSREWLGLKSDWYEGLELYVP 113
BLAST of Cullin-3 vs. Planmine SMEST
Match: SMESG000003282.1 (SMESG000003282.1) HSP 1 Score: 90.5077 bits (223), Expect = 1.027e-18 Identity = 48/87 (55.17%), Postives = 52/87 (59.77%), Query Frame = 2 Query: 1307 SVPQEQSTNYYVSASD------DIDKVEKMRWTTFDQFTKRAFTVCRINLPNDKANWPTVSAIAQHFLKNLFASMLSAFQSDLNIAK 1549 + ++QSTNYYVSASD DIDKVEKM WT FDQFTKRAFTV RINLPNDKANW F K L + L K Sbjct: 228 CIDKQQSTNYYVSASDATITQEDIDKVEKMHWTIFDQFTKRAFTVWRINLPNDKANWADGQCNCPAFFKKLICKHVVCISIRLKYCK 314 HSP 2 Score: 79.7221 bits (195), Expect = 4.056e-15 Identity = 36/45 (80.00%), Postives = 40/45 (88.89%), Query Frame = 1 Query: 1450 SQLADGQCDCPTFFKKFICKHVVGISIRLKYCKVPAVAKNTSIGS 1584 + ADGQC+CP FFKK ICKHVV ISIRLKYCKVPA+AKNTSIG+ Sbjct: 282 ANWADGQCNCPAFFKKLICKHVVCISIRLKYCKVPALAKNTSIGN 326 The following BLAST results are available for this feature:
BLAST of Cullin-3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cullin-3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cullin-3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Cullin-3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Cullin-3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cullin-3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cullin-3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30015048 ID=SMED30015048|Name=Cullin-3|organism=Schmidtea mediterranea sexual|type=transcript|length=4621bpback to top protein sequence of SMED30015048-orf-1 >SMED30015048-orf-1 ID=SMED30015048-orf-1|Name=SMED30015048-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=165bp MPFTSSTNNNIESNNRVLKDEETIRERTPLSRFSKQALDIVKKWSLAYPRback to top protein sequence of SMED30015048-orf-2 >SMED30015048-orf-2 ID=SMED30015048-orf-2|Name=SMED30015048-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=232bp MQSQPSTFQSLTATDGVSEPNFNQGYQSSQIVGDVGASFNSFSGSTSQSIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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