Thyroglobulin

Overview
NameThyroglobulin
Smed IDSMED30015030
Length (bp)747
Neoblast Clusters

Zeng et. al., 2018




 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30015030

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30015030h1SMcG0022941 dd_Smed_v6_84104_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
copulatory apparatusSMED30015030h1SMcG0020767 PL04013A1D02smed_ncbi_20240424PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
reproductive organSMED30015030h1SMcG0020767 Contig34141uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30015030h1SMcG0020767 Contig34141newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Thyroglobulin vs. Ensembl Human
Match: TG (thyroglobulin [Source:HGNC Symbol;Acc:HGNC:11764])

HSP 1 Score: 60.4622 bits (145), Expect = 8.626e-10
Identity = 37/124 (29.84%), Postives = 56/124 (45.16%), Query Frame = 2
Query:  347 TAKESPT-YFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNK---------------ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICP 670
            T +++P   FVP C + GSY+ +QC    C+C NS GK +     +     C    E+ + +               +  C S G + P+QC N+ C+CV+  G A+ G    R AI     CP
Sbjct:  607 TCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPG---TRSAIGKPKKCP 727          
BLAST of Thyroglobulin vs. Ensembl Xenopus
Match: amd1 (adenosylmethionine decarboxylase 1 [Source:Xenbase;Acc:XB-GENE-484611])

HSP 1 Score: 50.447 bits (119), Expect = 1.564e-6
Identity = 34/129 (26.36%), Postives = 52/129 (40.31%), Query Frame = 2
Query:  353 KESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNC--KCVLERDKNKILR-------------CKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK*KLFSG 694
            K S   ++P C   G Y+ IQC +  C+C +  G+ I     +     C  KC  ER +   +R             C   G +  +QC   +CFCV+  G  + G   V    +    CP   +L +G
Sbjct:  610 KRSSEIYIPACKEDGRYNDIQCSKAECWCVDDQGREIDRTRTQGTHPRCPTKCEKERYRQTAVRESLPPGAELFIPACDLEGHFLTVQCTGKLCFCVDLEGRIIPGTQKVSGGDIQ---CPSLCQLAAG 735          
BLAST of Thyroglobulin vs. Ensembl Mouse
Match: Tg (thyroglobulin [Source:MGI Symbol;Acc:MGI:98733])

HSP 1 Score: 55.8398 bits (133), Expect = 1.828e-8
Identity = 33/113 (29.20%), Postives = 52/113 (46.02%), Query Frame = 2
Query:  335 YNISTAKESP-TYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNC--KCVLERDKNKIL-------------RCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            ++    K+ P  +FVP C + GSY+ IQC    C+C +S GK +     +     C  KC  +R + + L              C   G + P+QC N+ C+CV+  G  + G
Sbjct:  603 FSAQACKQMPGKFFVPSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCEKQRAQMQSLASAQPAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPG 715          

HSP 2 Score: 48.1358 bits (113), Expect = 7.350e-6
Identity = 28/103 (27.18%), Postives = 47/103 (45.63%), Query Frame = 2
Query:  371 FVPICDSFGSYDPIQCRRD--TCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKIL--------------RCKSNGEYKPIQC--ANTMCFCVNRSGIAVQG 625
            +VP C   GS+  +QC+ D  +C+C +S G+ +         + C    +  K +IL              +C+ +G Y P+QC      C+CV+  G+ V G
Sbjct:   49 YVPQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPGSRQLGRPTVCLSFCQLHKQRILLGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG 151          
BLAST of Thyroglobulin vs. UniProt/SwissProt
Match: sp|P01266|THYG_HUMAN (Thyroglobulin OS=Homo sapiens OX=9606 GN=TG PE=1 SV=5)

HSP 1 Score: 60.4622 bits (145), Expect = 4.142e-9
Identity = 37/124 (29.84%), Postives = 56/124 (45.16%), Query Frame = 2
Query:  347 TAKESPT-YFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNK---------------ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICP 670
            T +++P   FVP C + GSY+ +QC    C+C NS GK +     +     C    E+ + +               +  C S G + P+QC N+ C+CV+  G A+ G    R AI     CP
Sbjct:  607 TCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPG---TRSAIGKPKKCP 727          
BLAST of Thyroglobulin vs. UniProt/SwissProt
Match: sp|P06882|THYG_RAT (Thyroglobulin OS=Rattus norvegicus OX=10116 GN=Tg PE=1 SV=4)

HSP 1 Score: 58.151 bits (139), Expect = 2.351e-8
Identity = 34/106 (32.08%), Postives = 49/106 (46.23%), Query Frame = 2
Query:  353 KESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNC--KCVLERDKNKIL-------------RCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            + S  +FVP C + GSY+ IQC    C+C NS GK +           C  KC  +R + + L              C S G + P+QC N+ C+CV+  G  + G
Sbjct:  610 QTSGRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCEKQRAQMQNLAGAQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIPG 715          
BLAST of Thyroglobulin vs. UniProt/SwissProt
Match: sp|O08710|THYG_MOUSE (Thyroglobulin OS=Mus musculus OX=10090 GN=Tg PE=1 SV=3)

HSP 1 Score: 55.8398 bits (133), Expect = 1.279e-7
Identity = 33/113 (29.20%), Postives = 52/113 (46.02%), Query Frame = 2
Query:  335 YNISTAKESP-TYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNC--KCVLERDKNKIL-------------RCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            ++    K+ P  +FVP C + GSY+ IQC    C+C +S GK +     +     C  KC  +R + + L              C   G + P+QC N+ C+CV+  G  + G
Sbjct:  603 FSAQACKQMPGKFFVPSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCEKQRAQMQSLASAQPAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPG 715          
BLAST of Thyroglobulin vs. UniProt/SwissProt
Match: sp|P01267|THYG_BOVIN (Thyroglobulin OS=Bos taurus OX=9913 GN=TG PE=1 SV=1)

HSP 1 Score: 54.299 bits (129), Expect = 4.102e-7
Identity = 31/117 (26.50%), Postives = 52/117 (44.44%), Query Frame = 2
Query:  365 TYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNK---------------ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICP 670
            + FVP C + GSY+ +QC    C+C ++ G+ ++    +     C    E+ + +               +  C S G + P+QC N+ C+CV+  G   Q I   R A+     CP
Sbjct:  613 SLFVPACTAEGSYEEVQCFAGDCWCVDAQGRELAGSRVRGGRPRCPTECEKQRARMQSLLGSQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEG---QPIPGTRSALGEPKKCP 726          
BLAST of Thyroglobulin vs. UniProt/SwissProt
Match: sp|F1RRV3|THYG_PIG (Thyroglobulin OS=Sus scrofa OX=9823 GN=TG PE=1 SV=5)

HSP 1 Score: 51.2174 bits (121), Expect = 3.883e-6
Identity = 24/102 (23.53%), Postives = 46/102 (45.10%), Query Frame = 2
Query:  365 TYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNK---------------ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            + FVP C + GSY+ +QC    C+C ++ G+ ++    +     C    E+ + +               +  C   G + P+QC ++ C+CV+  G  + G
Sbjct:  615 SLFVPSCTAEGSYEDVQCFAGECWCVDARGRELAGSRARGGRPRCPTACEKQRERMQSLLGRQPAGSSVFVPSCTREGHFLPVQCFSSDCYCVDADGQPIPG 716          
BLAST of Thyroglobulin vs. TrEMBL
Match: A0A1S3J5E7 (equistatin-like OS=Lingula unguis OX=7574 GN=LOC106170269 PE=4 SV=1)

HSP 1 Score: 70.4774 bits (171), Expect = 1.122e-11
Identity = 35/107 (32.71%), Postives = 55/107 (51.40%), Query Frame = 2
Query:  377 PICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSN---CKCVLERDK-------NKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLIC 667
            P CD+ G+Y   QC+  +CFC N  G R+  Y  +F  +    C C  + D+        K+  CK NG Y+  QC  ++C+CV+  G  ++   PV ++ V +L C
Sbjct:   26 PTCDADGTYSAKQCKEASCFCVNKDGDRLGDYSARFWEAKDMTCNCARDEDEYQKKGLIGKMYICKENGNYEKYQCTGSVCYCVDEKGSKLESTPPVSISAVKTLNC 132          
BLAST of Thyroglobulin vs. TrEMBL
Match: A0A1S3IF36 (uncharacterized protein LOC106163748 OS=Lingula unguis OX=7574 GN=LOC106163748 PE=4 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 7.316e-9
Identity = 34/107 (31.78%), Postives = 53/107 (49.53%), Query Frame = 2
Query:  377 PICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLS---NCKCVLERDK-------NKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLIC 667
            P CD+ G+Y   QC   +CFC N  G R+  Y  +F  +    C C  + D+        K+  C  NG Y+  QC  ++C+CV+  G  ++   PV ++ V +L C
Sbjct:  124 PTCDADGTYSAKQCIEASCFCVNKDGDRLGDYSARFWEAKDMTCNCARDEDEYQKKGLIGKMYICNENGNYEKYQCTGSVCYCVDEKGSKLESTPPVSISAVKTLNC 230          
BLAST of Thyroglobulin vs. TrEMBL
Match: A0A2T7PUN3 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_04128 PE=4 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 4.599e-8
Identity = 34/95 (35.79%), Postives = 49/95 (51.58%), Query Frame = 2
Query:  371 FVPICDSFGS--YDPIQCRRDTCFCSNSLGKRISSYFDK--FNLSNCKCVLERD-------KNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQ 622
            F+P CD+  +  Y P+QC    C+C +S G R+S Y +       NC+C  E D       + +I  C  +G Y P +C  + CFCVNR G  +Q
Sbjct:   40 FLPRCDAGNTALYSPLQCHGSVCYCVSSDGTRLSDYSNIPIGTPGNCECAREEDEFRKTGMRGQIFNCAPDGTYSPTRCTGSRCFCVNRDGTRMQ 134          
BLAST of Thyroglobulin vs. TrEMBL
Match: B0WKC4 (Uncharacterized protein OS=Culex quinquefasciatus OX=7176 GN=6039563 PE=4 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 6.912e-8
Identity = 45/156 (28.85%), Postives = 70/156 (44.87%), Query Frame = 2
Query:  242 GCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDT----CFCSNSLGKRI--SSYFDKFNLSNCKCVLERD-------KNKILRCKSNGEYKPIQCANTMCFCVN-RSGIAVQGITPVRLAIVTSLIC 667
            GC     C   L C  G C  +  ++ C    ++         + P CDS G + P+QCR D     CFC +S G+RI  S +  +     C C   R        ++  L C SNG ++P+QC   +C+CV  ++G  +  +  V  ++ T L C
Sbjct:   63 GCGALSPCLPGLTCRSGSCVLD--SSSCLSAEHVPPE----VSWTPTCDSSGRFQPVQCRGDLLHGRCFCYSSTGRRIFGSEWRGRATDMTCACSRLRSDLEASGRQDVTLHCSSNGNFEPLQCDGGVCWCVEPKTGQPLPQVPAVLPSMWTKLPC 212          
BLAST of Thyroglobulin vs. TrEMBL
Match: A0A1Q3FHF9 (Putative thyroglobulin type i repeat protein OS=Culex tarsalis OX=7177 PE=4 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 1.056e-7
Identity = 46/156 (29.49%), Postives = 68/156 (43.59%), Query Frame = 2
Query:  245 CKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTY-FVPICDSFGSYDPIQCRRDT----CFCSNSLGKRI--SSYFDKFNLSNCKCVLERD-------KNKILRCKSNGEYKPIQCANTMCFCVN-RSGIAVQGITPVRLAIVTSLIC 667
            C     C   L C    C  +  N        ++T    P   + P CDS G + P+QCR D     CFC +S G+RI  S +  K     C C   R        ++  L C SNG ++P+QC   +C+CV  ++G  +  +  V  ++ T L C
Sbjct:   64 CNELSPCLPGLTCTNESCGLDSANC-------LATEHAPPEISWTPSCDSSGHFQPVQCRGDLLSGRCFCYSSTGRRIFGSEWRGKATDMTCACSRLRSDLEASGRQDVTLHCSSNGNFEPLQCDGGVCWCVEPKTGQPLPEVPAVLPSMWTKLPC 212          
BLAST of Thyroglobulin vs. Ensembl Cavefish
Match: tg (thyroglobulin [Source:NCBI gene;Acc:103037495])

HSP 1 Score: 55.0694 bits (131), Expect = 2.938e-8
Identity = 32/137 (23.36%), Postives = 62/137 (45.26%), Query Frame = 2
Query:  308 PMNTKCYKNYNISTAKESPT-YFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNK---------------ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICP 670
            P+    ++N+++ ++  SP+  ++P C   G Y  +QC+   C+C++S G+ +           C    E+++                 I +C+ +GEY  +QC    CFC+++ G+         L   +SL CP
Sbjct:  603 PLFQAVFQNFDVCSSPASPSSLYLPQCTEDGQYQAVQCQGSECWCADSQGQEVMGSRSIGYRPRCPSRCEKERMMAIAVKASSSAGSEVFIPKCEEDGEYVSLQCLGKSCFCLDQRGVRYS-----TLGSGSSLQCP 734          

HSP 2 Score: 51.9878 bits (123), Expect = 2.571e-7
Identity = 33/106 (31.13%), Postives = 47/106 (44.34%), Query Frame = 2
Query:  344 STAKESPTYFVPICDSFGSYDPIQCRRD-TCFCSNSLGKRISSYFDKFNLSNC--KCVLER-------DKNKILRCKSNGEYKPIQCANTM--CFCVNRSGIAVQG 625
            S   E     +P C   G Y  +QC R   C+C NS G  I        +  C   C L+R       D   + RC  +GEY+P+QC   +  C+CV+  G+ + G
Sbjct:   70 SVGSEQQNEHIPQCSEDGRYRYVQCNRGGECWCVNSDGTEIPGSRQNDTVVTCLTPCQLQRQRLLLSGDAGVVPRCLDSGEYEPVQCDGALGQCWCVDMEGMEIYG 175          
BLAST of Thyroglobulin vs. Ensembl Sea Lamprey
Match: tg (thyroglobulin [Source:ZFIN;Acc:ZDB-GENE-030519-1])

HSP 1 Score: 47.7506 bits (112), Expect = 1.555e-6
Identity = 28/102 (27.45%), Postives = 44/102 (43.14%), Query Frame = 2
Query:  371 FVPIC-DSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLS-NCKCVLERDKNKIL---------------RCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            FV  C +  G+Y+P+QC    C+C ++ G+ I+           C    E ++ + L                C   G+Y+P+QC+   CFCV   G  V G
Sbjct:  606 FVARCGEDGGAYEPVQCHGAACWCVDAHGREIAGTRAVGGAPPRCPSACEGERARALLARRGRPVGTPLFVPECDGAGDYRPVQCSGDRCFCVGAGGAEVPG 707          
BLAST of Thyroglobulin vs. Ensembl Nematostella
Match: EDO40369 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7C0])

HSP 1 Score: 48.9062 bits (115), Expect = 3.536e-7
Identity = 35/122 (28.69%), Postives = 53/122 (43.44%), Query Frame = 2
Query:  317 TKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFD-------KFNLSNCK------CVLERD--KNKILRCKSNGEYKPIQC--ANTMCFCVNRSGIAVQG 625
            T C + Y  +T+   P  F P C + GS++ +QC +    C+C +  G  I               LS C+        L R   +  I  CKS+G Y+ +QC      C+CV+  G+ V G
Sbjct:   72 TPCQRRYQEATSSPVPGSFAPRCRADGSFEEVQCHKSQGYCWCVDQFGNEIPRTRSIKPVRCPSPILSPCQRRRLLGTALGRGNVEGYIPHCKSDGRYEEVQCHTGTKYCWCVDEKGVEVWG 193          
BLAST of Thyroglobulin vs. Ensembl Nematostella
Match: EDO40364 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7B5])

HSP 1 Score: 46.595 bits (109), Expect = 1.899e-6
Identity = 42/151 (27.81%), Postives = 67/151 (44.37%), Query Frame = 2
Query:  284 VKGECSTNPMNTKCYKN--------YNISTAKESPT---YFVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFDKF---------NLSNCK------CVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIV 652
            + G  ST P+  KC K           +  A E+P+    FVP C + G ++ +QC   T  C+C ++ G  I     K          +L+ C+       V       + +C+S+G Y  +QC   +C+CV++ GI +QG    RL I 
Sbjct:   54 IMGSRSTGPV--KCTKQGVPETECQSQVKQALETPSGKGRFVPRCKADGQFEEVQCNEWTGQCWCVDNSGIEIQGTRTKDFVSCPGQTNSLTVCQYKHQVSSVNAAPGAFVPQCRSDGGYDVVQCRGAVCYCVDKRGIEIQG---TRLPIA 199          

HSP 2 Score: 46.2098 bits (108), Expect = 2.907e-6
Identity = 34/124 (27.42%), Postives = 55/124 (44.35%), Query Frame = 2
Query:  317 TKCYKNYN-ISTAKESPTYFVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFDKFNL-------------SNCKCVLERDKNK---ILRCKSNGEYKPIQC--ANTMCFCVNRSGIAVQG 625
            T C K    + + +  P  + P C   G ++ +QC   T  C+C +S G+ I        +             S  K  LE    K   + RCK++G+++ +QC      C+CV+ SGI +QG
Sbjct:    3 TPCQKQKQALGSRRLIPDRYTPTCKPDGRFEEVQCNPATSACWCVDSDGQEIMGSRSTGPVKCTKQGVPETECQSQVKQALETPSGKGRFVPRCKADGQFEEVQCNEWTGQCWCVDNSGIEIQG 126          
BLAST of Thyroglobulin vs. Ensembl Nematostella
Match: EDO40373 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7C4])

HSP 1 Score: 45.0542 bits (105), Expect = 7.056e-6
Identity = 35/122 (28.69%), Postives = 53/122 (43.44%), Query Frame = 2
Query:  317 TKCYKNYNIS---TAKESPTYFVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFDK--------FNLSNCKCVLERDKNK---------ILRCKSNGEYKPIQCANTM--CFCVNRSG 610
            T C K   I+   T   +P  FVP C S G YD +QC   T  C+C +  G  I +   +          LS C+   +R             +  C S G+Y+ +QC ++   C+CV++ G
Sbjct:   56 TMCQKERQIAIGWTGVAAPGSFVPKCKSSGDYDTVQCHGSTGFCWCVDDDGNEIPATRVRGRPMCGLLAGLSQCQQERQRHMGVLGIAPPGRFVPACTSTGQYERVQCHSSTGYCWCVDKFG 177          
BLAST of Thyroglobulin vs. Ensembl Nematostella
Match: EDO40372 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7C3])

HSP 1 Score: 44.669 bits (104), Expect = 7.466e-6
Identity = 39/136 (28.68%), Postives = 60/136 (44.12%), Query Frame = 2
Query:  293 ECSTNPMNTKCYKN----YNISTAKESPTYFVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFDKFNLSNCK----CVLERDKNKIL-------------RCKSNGEYKPIQCA--NTMCFCVNRSGIAVQG 625
            +CS     T C K     Y +S +  +  Y VP CD+ G Y+P+QC   T  C+C +  G  I     +     CK       ER++ + L              C+ +G Y+ +QC   +  C+CV+RSG  + G
Sbjct:   45 DCSARVGLTPCQKQRFNAYGVSESTPADRY-VPRCDASGGYEPVQCLSTTGHCWCVDKDGIEIRGTRRRGVRPVCKQGYNTPCERERYRALGWTGLRVTGLWVPDCRPDGSYESVQCHALSGYCWCVDRSGHELFG 179          
BLAST of Thyroglobulin vs. Ensembl Nematostella
Match: EDO40371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7C2])

HSP 1 Score: 44.2838 bits (103), Expect = 9.184e-6
Identity = 31/107 (28.97%), Postives = 49/107 (45.79%), Query Frame = 2
Query:  371 FVPICDSFGSYDPIQCRRDT--CFCSNSLGKRISSYFDKFNLSNCK-----CVLERDKNKIL-------------RCKSNGEYKPIQCANT--MCFCVNRSGIAVQG 625
            FVP C   G+Y+ +QC+  T  C+C ++ G  +        L  C       V ++D+ + L             RC+S+G Y PIQC  +   C+CV+  G  + G
Sbjct:   78 FVPRCTLDGAYEDVQCQESTGECWCVDAQGSELDGTR-STELVTCHKHMSPSVCQQDRMQALAWSGRLVVGAFIPRCRSDGSYDPIQCHESPGQCWCVDVHGNELTG 183          
BLAST of Thyroglobulin vs. Ensembl Medaka
Match: ENSORLT00000046650.1 (pep primary_assembly:ASM223467v1:16:31876438:31883319:-1 gene:ENSORLG00000030206.1 transcript:ENSORLT00000046650.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.595 bits (109), Expect = 3.498e-6
Identity = 33/115 (28.70%), Postives = 49/115 (42.61%), Query Frame = 2
Query:  347 TAKESPTYFVPICDSFGSYDPIQCRRD-TCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKIL-----------RCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVT 655
             A E+ + FVP C+  GSY   QC++   C+C +  G+ +           C      +KN  L           +C  +G + P+QC  T C+CV   G  V G    +L  VT
Sbjct:   49 AALETSSVFVPTCERGGSYSFTQCQQGGQCWCVDPSGREVPGTRQLGGPLACG-----EKNHPLIANMAAGLQRRQCGPDGSFAPLQCDVTSCWCVTEYGQEVVGTRTPQLTGVT 158          
BLAST of Thyroglobulin vs. Planmine SMEST
Match: SMESG000017159.1 (SMESG000017159.1)

HSP 1 Score: 312.768 bits (800), Expect = 1.281e-109
Identity = 153/153 (100.00%), Postives = 153/153 (100.00%), Query Frame = 2
Query:  218 IFSTEFVHGCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK 676
            IFSTEFVHGCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK
Sbjct:   10 IFSTEFVHGCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK 162          
BLAST of Thyroglobulin vs. Planmine SMEST
Match: SMESG000017159.1 (SMESG000017159.1)

HSP 1 Score: 282.722 bits (722), Expect = 4.448e-98
Identity = 139/139 (100.00%), Postives = 139/139 (100.00%), Query Frame = 2
Query:  260 MCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK 676
            MCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK
Sbjct:    1 MCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLICPEK 139          
BLAST of Thyroglobulin vs. Planmine SMEST
Match: SMESG000017161.1 (SMESG000017161.1)

HSP 1 Score: 105.531 bits (262), Expect = 4.255e-28
Identity = 57/149 (38.26%), Postives = 79/149 (53.02%), Query Frame = 2
Query:  242 GCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLER-------DKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLIC 667
            GC +S+ C    VCV G CS NP+ TKCY+ Y+          F+P C + G Y P+QC  + C+CS+  GK+IS+YF+    SNCKC L++           I  C  NG Y+PIQC  + C+CV+  G  + G   V +     L C
Sbjct:   18 GCNDSKGCTDLEVCVSGNCSKNPLTTKCYQEYDKVMKNLLFGSFIPCCKTNGIYCPVQCPTNICYCSSPDGKKISNYFNINENSNCKCGLDKYLYSLNMAVGIIFNCNENGSYRPIQCLGSSCYCVDAQGKKIPGTISVHIEKANELKC 166          
BLAST of Thyroglobulin vs. Planmine SMEST
Match: SMESG000017039.1 (SMESG000017039.1)

HSP 1 Score: 100.908 bits (250), Expect = 2.538e-26
Identity = 56/158 (35.44%), Postives = 82/158 (51.90%), Query Frame = 2
Query:  218 IFSTEFVHGCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCV---LERDKNK-----ILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVRLAIVTSLIC 667
            I   E   GC++S  C+ P VC+ G+C  NP+ TKC++ Y  +    + T  +P CDS G+Y P+QC+   C+CSN  G  I  Y D    S+CKC    +E  +N         CK++G Y  +QC  T CFC +  G+ + G   V      +L+C
Sbjct:   10 ILLVEATRGCEDSFDCRPPKVCMSGKCYANPLTTKCFQIYGKAIKSMADT-LIPRCDSNGNYAPVQCQNGKCWCSNRDGITIHDYPDAKKKSHCKCARASIEFKQNSDGPITAFFCKTDGNYGDVQCKQTTCFCTDEDGVRMPGKATVDYEKRKTLLC 166          
BLAST of Thyroglobulin vs. Planmine SMEST
Match: SMESG000017157.1 (SMESG000017157.1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.973e-23
Identity = 47/128 (36.72%), Postives = 70/128 (54.69%), Query Frame = 2
Query:  242 GCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYNISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNLSNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQG 625
            GC+ S  CK PLVCV+G C  NP++T CYK+ + +        F+P CDS G Y  IQC    C+C +  G R+  +   ++ S CKC    D +   +C+ +G +K   C  + C+C+N +G  V G
Sbjct:   18 GCEESSDCKQPLVCVEGICGLNPLSTTCYKDLDSAIKSILIGRFMPRCDSKGLYFRIQCTNKLCYCYHREGYRLQMFSQVYDNSKCKCAQLVDYSTFNKCRKDGSFKSYWCNTSQCWCINENGKIVSG 145          
The following BLAST results are available for this feature:
BLAST of Thyroglobulin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
TG8.626e-1029.84thyroglobulin [Source:HGNC Symbol;Acc:HGNC:11764][more]
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BLAST of Thyroglobulin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Thyroglobulin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Thyroglobulin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Thyroglobulin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
amd11.564e-626.36adenosylmethionine decarboxylase 1 [Source:Xenbase... [more]
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BLAST of Thyroglobulin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Tg1.828e-829.20thyroglobulin [Source:MGI Symbol;Acc:MGI:98733][more]
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BLAST of Thyroglobulin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P01266|THYG_HUMAN4.142e-929.84Thyroglobulin OS=Homo sapiens OX=9606 GN=TG PE=1 S... [more]
sp|P06882|THYG_RAT2.351e-832.08Thyroglobulin OS=Rattus norvegicus OX=10116 GN=Tg ... [more]
sp|O08710|THYG_MOUSE1.279e-729.20Thyroglobulin OS=Mus musculus OX=10090 GN=Tg PE=1 ... [more]
sp|P01267|THYG_BOVIN4.102e-726.50Thyroglobulin OS=Bos taurus OX=9913 GN=TG PE=1 SV=... [more]
sp|F1RRV3|THYG_PIG3.883e-623.53Thyroglobulin OS=Sus scrofa OX=9823 GN=TG PE=1 SV=... [more]
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BLAST of Thyroglobulin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3J5E71.122e-1132.71equistatin-like OS=Lingula unguis OX=7574 GN=LOC10... [more]
A0A1S3IF367.316e-931.78uncharacterized protein LOC106163748 OS=Lingula un... [more]
A0A2T7PUN34.599e-835.79Uncharacterized protein OS=Pomacea canaliculata OX... [more]
B0WKC46.912e-828.85Uncharacterized protein OS=Culex quinquefasciatus ... [more]
A0A1Q3FHF91.056e-729.49Putative thyroglobulin type i repeat protein OS=Cu... [more]
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BLAST of Thyroglobulin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tg2.938e-823.36thyroglobulin [Source:NCBI gene;Acc:103037495][more]
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BLAST of Thyroglobulin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tg1.555e-627.45thyroglobulin [Source:ZFIN;Acc:ZDB-GENE-030519-1][more]
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BLAST of Thyroglobulin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Thyroglobulin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO403693.536e-728.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403641.899e-627.81Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403737.056e-628.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403727.466e-628.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403719.184e-628.97Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Thyroglobulin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSORLT00000046650.13.498e-628.70pep primary_assembly:ASM223467v1:16:31876438:31883... [more]
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BLAST of Thyroglobulin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000017159.11.281e-109100.00SMESG000017159.1[more]
SMESG000017159.14.448e-98100.00SMESG000017159.1[more]
SMESG000017161.14.255e-2838.26SMESG000017161.1[more]
SMESG000017039.12.538e-2635.44SMESG000017039.1[more]
SMESG000017157.11.973e-2336.72SMESG000017157.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015030 ID=SMED30015030|Name=Thyroglobulin|organism=Schmidtea mediterranea sexual|type=transcript|length=747bp
TGTGTTAAATTTATAAAATGATATTAATTGCATTTTTAGAAAACAAGTAA
ATTTTGAATAAATTAATTTTATTTTACTATGTTTCATTTTCATTCTACTC
TATGTCGCCTTTCCTGAATCCGGGAGGACTCCTTTCTTGTATAAATTGAA
ACGGGCTTTTACTGGAAATATTGTTCTTTTAAATTGAGTTATGAGTGTAT
TATTAGTTCTCTTGGTTATATTTTCAACTGAATTTGTCCACGGTTGTAAG
AATTCGAGAATGTGTAAAACCCCTTTGGTTTGTGTGAAAGGCGAGTGTTC
CACCAACCCCATGAATACCAAATGCTATAAAAACTACAACATTTCAACAG
CTAAAGAGTCCCCCACTTATTTCGTACCTATCTGTGATTCTTTTGGTAGC
TATGATCCTATCCAGTGTAGACGAGATACGTGCTTTTGTTCCAACAGTTT
GGGAAAGAGAATTTCATCTTATTTTGATAAATTCAATCTATCGAATTGCA
AATGTGTCTTAGAAAGGGATAAGAATAAGATCCTTCGGTGCAAAAGCAAT
GGCGAATACAAACCTATACAATGTGCCAATACGATGTGCTTTTGTGTTAA
TAGATCCGGAATTGCGGTTCAAGGAATTACTCCTGTTAGACTTGCCATAG
TGACGAGTCTGATTTGTCCGGAGAAATAAAAATTATTTTCTGGTTATTAA
AACTGATTTATAATTATTCTATCGGTGTGAAAATTATTGAAAAACAG
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protein sequence of SMED30015030-orf-1

>SMED30015030-orf-1 ID=SMED30015030-orf-1|Name=SMED30015030-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=163bp
MSVLLVLLVIFSTEFVHGCKNSRMCKTPLVCVKGECSTNPMNTKCYKNYN
ISTAKESPTYFVPICDSFGSYDPIQCRRDTCFCSNSLGKRISSYFDKFNL
SNCKCVLERDKNKILRCKSNGEYKPIQCANTMCFCVNRSGIAVQGITPVR
LAIVTSLICPEK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000232copulatory apparatus
PLANA:0000419prepharyngeal region
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR036857Thyroglobulin_1_sf
IPR000716Thyroglobulin_1
Vocabulary: molecular function
TermDefinition
GO:0005179hormone activity
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
Vocabulary: biological process
TermDefinition
GO:0042446hormone biosynthetic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000716Thyroglobulin type-1SMARTSM00211TY_2coord: 62..109
e-value: 0.18
score: 11.2
coord: 114..151
e-value: 0.006
score: 24.2
IPR000716Thyroglobulin type-1PFAMPF00086Thyroglobulin_1coord: 53..93
e-value: 3.7E-8
score: 32.9
coord: 116..146
e-value: 1.1E-6
score: 28.1
IPR000716Thyroglobulin type-1PROSITEPS51162THYROGLOBULIN_1_2coord: 42..105
score: 8.173
IPR000716Thyroglobulin type-1PROSITEPS51162THYROGLOBULIN_1_2coord: 106..159
score: 6.834
IPR036857Thyroglobulin type-1 superfamilyGENE3DG3DSA:4.10.800.10coord: 42..103
e-value: 2.8E-9
score: 38.2
coord: 104..152
e-value: 4.1E-8
score: 34.4
IPR036857Thyroglobulin type-1 superfamilySUPERFAMILYSSF57610Thyroglobulin type-1 domaincoord: 116..147
IPR036857Thyroglobulin type-1 superfamilySUPERFAMILYSSF57610Thyroglobulin type-1 domaincoord: 44..106
NoneNo IPR availablePANTHERPTHR12352SECRETED MODULAR CALCIUM-BINDING PROTEINcoord: 14..146
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.855