P21 activated kinase-1

Overview
NameP21 activated kinase-1 (AFJ24790.1)
Smed IDSMED30014999
Length (bp)2705
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of P21 activated kinase-1 (SMED30014999) t-SNE clustered cells

Violin plots show distribution of expression levels for P21 activated kinase-1 (SMED30014999) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of P21 activated kinase-1 (SMED30014999) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for P21 activated kinase-1 (SMED30014999) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014999

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30014999SMESG000008326.1 Contig2271uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30014999SMESG000008326.1 Contig2271newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30014999SMESG000043190.1 Contig2271uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30014999SMESG000043190.1 Contig2271newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30014999SMESG000008326.1 dd_Smed_v4_5741_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30014999SMESG000008326.1 dd_Smed_v4_5741_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30014999SMESG000008326.1 dd_Smed_v4_5741_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 491.115 bits (1263), Expect = 8.954e-164
Identity = 250/358 (69.83%), Postives = 291/358 (81.28%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVA--------VHSPSA------IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + + S+A        V  PSA          +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  209 PPVIAPRPEHTKSIYTRSVVE-SIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 558

HSP 2 Score: 63.5438 bits (153), Expect = 1.270e-9
Identity = 51/148 (34.46%), Postives = 72/148 (48.65%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                      G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 159
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 491.115 bits (1263), Expect = 8.954e-164
Identity = 250/358 (69.83%), Postives = 291/358 (81.28%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVA--------VHSPSA------IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + + S+A        V  PSA          +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  209 PPVIAPRPEHTKSIYTRSVVE-SIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 558

HSP 2 Score: 63.5438 bits (153), Expect = 1.270e-9
Identity = 51/148 (34.46%), Postives = 72/148 (48.65%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                      G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 159
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 489.96 bits (1260), Expect = 1.202e-163
Identity = 246/357 (68.91%), Postives = 288/357 (80.67%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + +   +   P             S+    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  188 PPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 75.8702 bits (185), Expect = 1.798e-13
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 489.96 bits (1260), Expect = 1.202e-163
Identity = 246/357 (68.91%), Postives = 288/357 (80.67%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + +   +   P             S+    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  188 PPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 75.8702 bits (185), Expect = 1.798e-13
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Human
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 489.96 bits (1260), Expect = 1.202e-163
Identity = 246/357 (68.91%), Postives = 288/357 (80.67%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + +   +   P             S+    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  188 PPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 75.8702 bits (185), Expect = 1.798e-13
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 462.611 bits (1189), Expect = 9.800e-154
Identity = 235/351 (66.95%), Postives = 276/351 (78.63%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            PP I DRP +T SIYTKP E++                 QK K K+++ E+  KLR IVS+G+P+RKY+K +KIG GASG VY  IE ST  +VAIKQM LK QPKKELIINEI VM+ N+H N+VNYLDSYLV       DELWVVMEYL GGSLT+VVTE  M++G IAAVCRE LQAL+FLH+ +VIHRDIKSDNILLG+DGSVKLTDFGFCAQL+ EQ KR+TMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMA+EM++GEPPYLNENPLRA+YLIATNGKP+   +  ++++F DF+D  LEVQVE R SAS+LLTHPF+ R AKPL+SL  LIV AK+  A  S+
Sbjct:  179 PPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLV------CDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL-RCAKPLASLYYLIVAAKKSIAEASN 522

HSP 2 Score: 61.2326 bits (147), Expect = 2.501e-9
Identity = 29/70 (41.43%), Postives = 43/70 (61.43%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVIL-ENNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            P IS P +  H +H+ +   TGEF G+P  W  +L ++ ISK EQQQNP+AVL+AL        + +K++
Sbjct:   19 PVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQGESSGQKWL 88
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 462.996 bits (1190), Expect = 3.552e-153
Identity = 235/351 (66.95%), Postives = 276/351 (78.63%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            PP I DRP +T SIYTKP E++                 QK K K+++ E+  KLR IVS+G+P+RKY+K +KIG GASG VY  IE ST  +VAIKQM LK QPKKELIINEI VM+ N+H N+VNYLDSYLV       DELWVVMEYL GGSLT+VVTE  M++G IAAVCRE LQAL+FLH+ +VIHRDIKSDNILLG+DGSVKLTDFGFCAQL+ EQ KR+TMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMA+EM++GEPPYLNENPLRA+YLIATNGKP+   +  ++++F DF+D  LEVQVE R SAS+LLTHPF+ R AKPL+SL  LIV AK+  A  S+
Sbjct:  228 PPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLV------CDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL-RCAKPLASLYYLIVAAKKSIAEASN 571

HSP 2 Score: 64.6994 bits (156), Expect = 1.926e-10
Identity = 46/137 (33.58%), Postives = 68/137 (49.64%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVIL-ENNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            M    + D   PAPP+R +S   + ++   + KPLP  P  E  KK K               +   P IS P +  H +H+ +   TGEF G+P  W  +L ++ ISK EQQQNP+AVL+AL        + +K++
Sbjct:    1 MKAFSSYDEKPPAPPIRFSSSATRENQVVGL-KPLPKEP--EATKKKKTMPNPFMKKNKDKKEASEKPVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQGESSGQKWL 134
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 462.996 bits (1190), Expect = 3.667e-153
Identity = 235/351 (66.95%), Postives = 276/351 (78.63%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            PP I DRP +T SIYTKP E++                 QK K K+++ E+  KLR IVS+G+P+RKY+K +KIG GASG VY  IE ST  +VAIKQM LK QPKKELIINEI VM+ N+H N+VNYLDSYLV       DELWVVMEYL GGSLT+VVTE  M++G IAAVCRE LQAL+FLH+ +VIHRDIKSDNILLG+DGSVKLTDFGFCAQL+ EQ KR+TMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMA+EM++GEPPYLNENPLRA+YLIATNGKP+   +  ++++F DF+D  LEVQVE R SAS+LLTHPF+ R AKPL+SL  LIV AK+  A  S+
Sbjct:  225 PPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLV------CDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL-RCAKPLASLYYLIVAAKKSIAEASN 568

HSP 2 Score: 64.6994 bits (156), Expect = 1.901e-10
Identity = 46/137 (33.58%), Postives = 68/137 (49.64%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVIL-ENNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            M    + D   PAPP+R +S   + ++   + KPLP  P  E  KK K               +   P IS P +  H +H+ +   TGEF G+P  W  +L ++ ISK EQQQNP+AVL+AL        + +K++
Sbjct:    1 MKAFSSYDEKPPAPPIRFSSSATRENQVVGL-KPLPKEP--EATKKKKTMPNPFMKKNKDKKEASEKPVISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQGESSGQKWL 134
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3])

HSP 1 Score: 362.459 bits (929), Expect = 1.575e-116
Identity = 173/295 (58.64%), Postives = 227/295 (76.95%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQ 2267
            +  +LR+IV+  +P  KY+  ++IG GASG V+      +   VA+K+M  K QPKKE+++ EI VMK  RHPN+VNY++SYLV      AD+LWVVM+YL+GG+LT+VV +T +DEG IAAV +ECL+AL FLH ++++HRDIKSDN+LLG++G VKLTD GFCAQ+    +KR T+VGTPYWM+PE++ +KQY  KVD+WSLGIMALEMIDGEPPYL E PL+A+YLIA NGKPEIK++ RLS  F +FLDKCL V  ++R   +ELL HPF+ +KAKPLSSL P I   +E+
Sbjct:  139 VLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVD-----ADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQ-PGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFL-KKAKPLSSLIPYIRAVREK 426
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Match: max-2 (Serine/threonine-protein kinase max-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ3])

HSP 1 Score: 363.999 bits (933), Expect = 7.260e-115
Identity = 173/295 (58.64%), Postives = 227/295 (76.95%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQ 2267
            +  +LR+IV+  +P  KY+  ++IG GASG V+      +   VA+K+M  K QPKKE+++ EI VMK  RHPN+VNY++SYLV      AD+LWVVM+YL+GG+LT+VV +T +DEG IAAV +ECL+AL FLH ++++HRDIKSDN+LLG++G VKLTD GFCAQ+    +KR T+VGTPYWM+PE++ +KQY  KVD+WSLGIMALEMIDGEPPYL E PL+A+YLIA NGKPEIK++ RLS  F +FLDKCL V  ++R   +ELL HPF+ +KAKPLSSL P I   +E+
Sbjct:  311 VLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVD-----ADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQ-PGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFL-KKAKPLSSLIPYIRAVREK 598
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539)

HSP 1 Score: 485.723 bits (1249), Expect = 4.221e-160
Identity = 230/294 (78.23%), Postives = 259/294 (88.10%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I EKLR IVS+GDPNRKY K EKIGQGASG VY  IE+STG +VAIKQM L QQPKKELIINEI VM+ N+HPNVVNYLDSYLV      ++ELWVVMEYL GGSLT+VVTET MDEG IAAVCRE LQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQ++ EQ+KR+TMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EM++GEPPYLNENPL+ALYLIATNGKPEIKEK +LS  F DFLD+CLEV+V++R SA +LL HPF+ + A+PL+SLTPLI+ AKE
Sbjct:  413 ILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLV------SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-KLARPLASLTPLIMAAKE 699

HSP 2 Score: 63.929 bits (154), Expect = 5.908e-10
Identity = 34/72 (47.22%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK--EKYM 815
            PNIS P +  H VH+ F   TGEF G+P  W  +L N NISK EQ++NP+AVL+ L    +  K +   KYM
Sbjct:   81 PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714)

HSP 1 Score: 485.723 bits (1249), Expect = 4.221e-160
Identity = 230/294 (78.23%), Postives = 259/294 (88.10%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I EKLR IVS+GDPNRKY K EKIGQGASG VY  IE+STG +VAIKQM L QQPKKELIINEI VM+ N+HPNVVNYLDSYLV      ++ELWVVMEYL GGSLT+VVTET MDEG IAAVCRE LQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQ++ EQ+KR+TMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EM++GEPPYLNENPL+ALYLIATNGKPEIKEK +LS  F DFLD+CLEV+V++R SA +LL HPF+ + A+PL+SLTPLI+ AKE
Sbjct:  413 ILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLV------SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-KLARPLASLTPLIMAAKE 699

HSP 2 Score: 63.929 bits (154), Expect = 5.908e-10
Identity = 34/72 (47.22%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK--EKYM 815
            PNIS P +  H VH+ F   TGEF G+P  W  +L N NISK EQ++NP+AVL+ L    +  K +   KYM
Sbjct:   81 PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081716)

HSP 1 Score: 485.723 bits (1249), Expect = 4.221e-160
Identity = 230/294 (78.23%), Postives = 259/294 (88.10%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I EKLR IVS+GDPNRKY K EKIGQGASG VY  IE+STG +VAIKQM L QQPKKELIINEI VM+ N+HPNVVNYLDSYLV      ++ELWVVMEYL GGSLT+VVTET MDEG IAAVCRE LQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQ++ EQ+KR+TMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EM++GEPPYLNENPL+ALYLIATNGKPEIKEK +LS  F DFLD+CLEV+V++R SA +LL HPF+ + A+PL+SLTPLI+ AKE
Sbjct:  413 ILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLV------SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-KLARPLASLTPLIMAAKE 699

HSP 2 Score: 63.929 bits (154), Expect = 5.908e-10
Identity = 34/72 (47.22%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK--EKYM 815
            PNIS P +  H VH+ F   TGEF G+P  W  +L N NISK EQ++NP+AVL+ L    +  K +   KYM
Sbjct:   81 PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081715)

HSP 1 Score: 485.723 bits (1249), Expect = 4.221e-160
Identity = 230/294 (78.23%), Postives = 259/294 (88.10%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I EKLR IVS+GDPNRKY K EKIGQGASG VY  IE+STG +VAIKQM L QQPKKELIINEI VM+ N+HPNVVNYLDSYLV      ++ELWVVMEYL GGSLT+VVTET MDEG IAAVCRE LQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQ++ EQ+KR+TMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EM++GEPPYLNENPL+ALYLIATNGKPEIKEK +LS  F DFLD+CLEV+V++R SA +LL HPF+ + A+PL+SLTPLI+ AKE
Sbjct:  413 ILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLV------SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-KLARPLASLTPLIMAAKE 699

HSP 2 Score: 63.929 bits (154), Expect = 5.908e-10
Identity = 34/72 (47.22%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK--EKYM 815
            PNIS P +  H VH+ F   TGEF G+P  W  +L N NISK EQ++NP+AVL+ L    +  K +   KYM
Sbjct:   81 PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334544)

HSP 1 Score: 485.723 bits (1249), Expect = 4.221e-160
Identity = 230/294 (78.23%), Postives = 259/294 (88.10%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I EKLR IVS+GDPNRKY K EKIGQGASG VY  IE+STG +VAIKQM L QQPKKELIINEI VM+ N+HPNVVNYLDSYLV      ++ELWVVMEYL GGSLT+VVTET MDEG IAAVCRE LQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQ++ EQ+KR+TMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EM++GEPPYLNENPL+ALYLIATNGKPEIKEK +LS  F DFLD+CLEV+V++R SA +LL HPF+ + A+PL+SLTPLI+ AKE
Sbjct:  413 ILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLV------SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL-KLARPLASLTPLIMAAKE 699

HSP 2 Score: 63.929 bits (154), Expect = 5.908e-10
Identity = 34/72 (47.22%), Postives = 44/72 (61.11%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK--EKYM 815
            PNIS P +  H VH+ F   TGEF G+P  W  +L N NISK EQ++NP+AVL+ L    +  K +   KYM
Sbjct:   81 PNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM 152
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 475.322 bits (1222), Expect = 1.342e-157
Identity = 225/296 (76.01%), Postives = 254/296 (85.81%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQA 2270
            I EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE A
Sbjct:  287 ILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELLQHQFL-KVAKPLSSLTPLIIAAKEAA 575

HSP 2 Score: 66.2402 bits (160), Expect = 1.033e-10
Identity = 47/132 (35.61%), Postives = 71/132 (53.79%), Query Frame = 3 
Query:  441 PAPPLRTTSVI----HQNSENFN-ISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDK-NKNKEKYM 815
            PAPP+R TS +     ++S   N  SKPLP  P ++ +K+             ++      P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPMRNTSTMIGSSGKDSGPLNHGSKPLPPNPEDKRRKEGFIRSILTGGGDKTNKKKER-PEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETSNNQKYM 142
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 475.322 bits (1222), Expect = 1.342e-157
Identity = 225/296 (76.01%), Postives = 254/296 (85.81%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQA 2270
            I EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE A
Sbjct:  287 ILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELLQHQFL-KVAKPLSSLTPLIIAAKEAA 575

HSP 2 Score: 66.2402 bits (160), Expect = 1.033e-10
Identity = 47/132 (35.61%), Postives = 71/132 (53.79%), Query Frame = 3 
Query:  441 PAPPLRTTSVI----HQNSENFN-ISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDK-NKNKEKYM 815
            PAPP+R TS +     ++S   N  SKPLP  P ++ +K+             ++      P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPMRNTSTMIGSSGKDSGPLNHGSKPLPPNPEDKRRKEGFIRSILTGGGDKTNKKKER-PEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETSNNQKYM 142
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Match: pak2b (p21 protein (Cdc42/Rac)-activated kinase 2b [Source:ZFIN;Acc:ZDB-GENE-030131-3759])

HSP 1 Score: 466.848 bits (1200), Expect = 5.858e-155
Identity = 234/348 (67.24%), Postives = 286/348 (82.18%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKP--IEDKSVAVHSPS--AIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP +A RPE TKS+YT+P  I+     V SP   A +K ++  + KK K+++EEI +KLR IVS+GDP +KY ++EKIGQGASG V+  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+LVG      +EL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS +F DFL +CLE+ VEKR  + ELL HPF+ + AKPLSSLTPLI+ AK+
Sbjct:  191 PPVVAPRPEHTKSVYTRPSVIDPLPPPVTSPESDAASKATDRQRPKKGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVG------EELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPEKLSPIFRDFLGRCLEMDVEKRGGSKELLQHPFL-KLAKPLSSLTPLILAAKD 531

HSP 2 Score: 73.559 bits (179), Expect = 6.114e-13
Identity = 42/131 (32.06%), Postives = 66/131 (50.38%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNI-----SKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            PAPP+R +S I   +++  +     SKPLP +P    + K        +            P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K EQ++NP+AVL+ L         ++KY+
Sbjct:   12 PAPPVRMSSTIFSGAKDHALTANHSSKPLPSVPEERKRNKIYSIFSGAEKGGRRKDRDKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGRQKYL 142
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Match: pak2b (p21 protein (Cdc42/Rac)-activated kinase 2b [Source:ZFIN;Acc:ZDB-GENE-030131-3759])

HSP 1 Score: 466.848 bits (1200), Expect = 5.858e-155
Identity = 234/348 (67.24%), Postives = 286/348 (82.18%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKP--IEDKSVAVHSPS--AIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP +A RPE TKS+YT+P  I+     V SP   A +K ++  + KK K+++EEI +KLR IVS+GDP +KY ++EKIGQGASG V+  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+LVG      +EL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS +F DFL +CLE+ VEKR  + ELL HPF+ + AKPLSSLTPLI+ AK+
Sbjct:  191 PPVVAPRPEHTKSVYTRPSVIDPLPPPVTSPESDAASKATDRQRPKKGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVG------EELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPEKLSPIFRDFLGRCLEMDVEKRGGSKELLQHPFL-KLAKPLSSLTPLILAAKD 531

HSP 2 Score: 73.559 bits (179), Expect = 6.114e-13
Identity = 42/131 (32.06%), Postives = 66/131 (50.38%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNI-----SKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            PAPP+R +S I   +++  +     SKPLP +P    + K        +            P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K EQ++NP+AVL+ L         ++KY+
Sbjct:   12 PAPPVRMSSTIFSGAKDHALTANHSSKPLPSVPEERKRNKIYSIFSGAEKGGRRKDRDKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGRQKYL 142
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 466.848 bits (1200), Expect = 3.684e-154
Identity = 220/289 (76.12%), Postives = 249/289 (86.16%), Query Frame = 3 
Query: 1404 IVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQA 2270
            IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE A
Sbjct:  302 IVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELLQHQFL-KVAKPLSSLTPLIIAAKEAA 583
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Match: flii (FLII actin remodeling protein [Source:Xenbase;Acc:XB-GENE-478681])

HSP 1 Score: 484.952 bits (1247), Expect = 2.275e-162
Identity = 245/359 (68.25%), Postives = 289/359 (80.50%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTK----------PIEDKSVAVHSP--------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+          P ++ S +  +P        ++    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS +F DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  139 IAPRPEHTKSIYTRSVIEPVALTAPAKEASTSPVTPQPENSNSSTSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAIFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 490

HSP 2 Score: 64.3142 bits (155), Expect = 6.399e-10
Identity = 31/71 (43.66%), Postives = 45/71 (63.38%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   16 PEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 86
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Match: flii (FLII actin remodeling protein [Source:Xenbase;Acc:XB-GENE-478681])

HSP 1 Score: 485.723 bits (1249), Expect = 5.854e-162
Identity = 245/359 (68.25%), Postives = 289/359 (80.50%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTK----------PIEDKSVAVHSP--------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+          P ++ S +  +P        ++    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS +F DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVIEPVALTAPAKEASTSPVTPQPENSNSSTSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAIFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 542

HSP 2 Score: 76.6406 bits (187), Expect = 7.682e-14
Identity = 53/138 (38.41%), Postives = 77/138 (55.80%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            M+ S  ++   PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:    1 MSDSVDIEEKPPAPPLRMNSNNRDSSALNHCSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Match: flii (FLII actin remodeling protein [Source:Xenbase;Acc:XB-GENE-478681])

HSP 1 Score: 485.723 bits (1249), Expect = 1.152e-161
Identity = 245/359 (68.25%), Postives = 289/359 (80.50%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTK----------PIEDKSVAVHSP--------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+          P ++ S +  +P        ++    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS +F DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  206 IAPRPEHTKSIYTRSVIEPVALTAPAKEASTSPVTPQPENSNSSTSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAIFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 557

HSP 2 Score: 67.0106 bits (162), Expect = 8.795e-11
Identity = 53/153 (34.64%), Postives = 77/153 (50.33%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            M+ S  ++   PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:    1 MSDSVDIEEKPPAPPLRMNSNNRDSSALNHCSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLCGSQMGTGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Match: taf3 (TATA-box binding protein associated factor 3 [Source:Xenbase;Acc:XB-GENE-940280])

HSP 1 Score: 471.47 bits (1212), Expect = 7.678e-157
Identity = 238/347 (68.59%), Postives = 285/347 (82.13%), Query Frame = 3 
Query: 1227 KDPPP-IADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            K PPP IA RPE TKS+YT+ + D        S     +   QKKK+K+S+EEI EKLR IVS+GDP +KY ++EKIGQGASG V+  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+LV      +DEL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE+++  +LS +F DFL++ LE+ VEKR SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  173 KAPPPVIAPRPEHTKSMYTRSVIDPIPPPPGDSDSAAKAGDRQKKKTKMSDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLV------SDELYVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQKPEKLSPIFRDFLNRSLEMDVEKRGSARELLQHPFL-KLAKPLSSLTPLILAAKE 512

HSP 2 Score: 75.485 bits (184), Expect = 1.874e-13
Identity = 49/138 (35.51%), Postives = 73/138 (52.90%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNIS-KPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            M+ +  L+   PAPP R +S   ++    N S KPLPLIP     K         K  +      P    IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K+ +K+KY+
Sbjct:    1 MSDNGELEDKPPAPPARISSTGTKDPLTSNHSHKPLPLIPEKPRNKIISMFSGTEKGSRKKERERP---EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKHTDKQKYL 135
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Match: qsox2 (quiescin sulfhydryl oxidase 2 [Source:Xenbase;Acc:XB-GENE-986398])

HSP 1 Score: 470.7 bits (1210), Expect = 1.879e-156
Identity = 238/358 (66.48%), Postives = 283/358 (79.05%), Query Frame = 3 
Query: 1227 KDPPPIADRPEKTKSIYTK--------PIEDKSVAVHSPSAI--XXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQA 2270
            +DPP    RP+ TKSIYT+        P+  K    +  S     ++S    KKK K+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N+HPN+VNYLDSYLVG      +ELWVVMEYL GGSLT+VVTET M EG IAAVCRECLQAL+FLH+N VIHRDIKSDNILLG+DG+VKLTDFGFCAQ++ EQ KRSTMVGTPYWMAPEVVTRK YGPKVDVWSLGIMA+EM++GEPPYLNENPLRALYLIATNG P+++E  + S  F DFL +CLE+ VEKR SA +LL HPF+ + AKP+SSLTP I+  K+ A
Sbjct:  167 EDPPAFPPRPDHTKSIYTRSVIEPPVPPLAAKPTTENGSSVTDGAESSVDKTKKKPKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYIAVDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHPNIVNYLDSYLVG------EELWVVMEYLAGGSLTDVVTETCMQEGEIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGAVKLTDFGFCAQISPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPQLQEPEKKSPAFRDFLSRCLEMDVEKRGSARDLLQHPFL-KVAKPMSSLTPYIITGKQMA 517

HSP 2 Score: 58.5362 bits (140), Expect = 3.279e-8
Identity = 29/69 (42.03%), Postives = 43/69 (62.32%), Query Frame = 3 
Query:  615 ISAPISVMHKVHITFSQDTGEFAGVPLEWQVILEN-NISKIEQQQNPRAVLNALNILVDKNKNK-EKYM 815
            IS+P    H  H+     TGEF G+P +W  +L+  NISKI+Q++NP+ VL+ LN    +  +K +KYM
Sbjct:   65 ISSPFGYEHIYHVGIDPSTGEFTGMPKQWAQLLQTANISKIDQKKNPQVVLDVLNFYSSETTSKSQKYM 133
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656])

HSP 1 Score: 487.263 bits (1253), Expect = 9.900e-163
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 76.2554 bits (186), Expect = 9.933e-14
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656])

HSP 1 Score: 487.263 bits (1253), Expect = 9.900e-163
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 76.2554 bits (186), Expect = 9.933e-14
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656])

HSP 1 Score: 487.263 bits (1253), Expect = 9.900e-163
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 76.2554 bits (186), Expect = 9.933e-14
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656])

HSP 1 Score: 487.263 bits (1253), Expect = 9.900e-163
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 537

HSP 2 Score: 76.2554 bits (186), Expect = 9.933e-14
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Match: Pak3 (p21 (RAC1) activated kinase 3 [Source:MGI Symbol;Acc:MGI:1339656])

HSP 1 Score: 486.878 bits (1252), Expect = 2.151e-162
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  206 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 552

HSP 2 Score: 65.855 bits (159), Expect = 1.462e-10
Identity = 51/142 (35.92%), Postives = 72/142 (50.70%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Match: sp|Q7YQL3|PAK3_PONPY (Serine/threonine-protein kinase PAK 3 OS=Pongo pygmaeus OX=9600 GN=PAK3 PE=2 SV=1)

HSP 1 Score: 489.574 bits (1259), Expect = 1.324e-162
Identity = 250/358 (69.83%), Postives = 291/358 (81.28%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVA--------VHSPSA------IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + + S+A        V  PSA          +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  203 PPVIAPRPEHTKSIYTRSVVE-SIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 552

HSP 2 Score: 65.855 bits (159), Expect = 1.184e-9
Identity = 51/142 (35.92%), Postives = 72/142 (50.70%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Match: sp|Q7YQL4|PAK3_PANTR (Serine/threonine-protein kinase PAK 3 OS=Pan troglodytes OX=9598 GN=PAK3 PE=2 SV=1)

HSP 1 Score: 489.574 bits (1259), Expect = 1.324e-162
Identity = 250/358 (69.83%), Postives = 291/358 (81.28%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVA--------VHSPSA------IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + + S+A        V  PSA          +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  203 PPVIAPRPEHTKSIYTRSVVE-SIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 552

HSP 2 Score: 65.855 bits (159), Expect = 1.184e-9
Identity = 51/142 (35.92%), Postives = 72/142 (50.70%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Match: sp|O75914|PAK3_HUMAN (Serine/threonine-protein kinase PAK 3 OS=Homo sapiens OX=9606 GN=PAK3 PE=1 SV=2)

HSP 1 Score: 489.574 bits (1259), Expect = 1.324e-162
Identity = 250/358 (69.83%), Postives = 291/358 (81.28%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVA--------VHSPSA------IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + + S+A        V  PSA          +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  203 PPVIAPRPEHTKSIYTRSVVE-SIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 552

HSP 2 Score: 65.855 bits (159), Expect = 1.184e-9
Identity = 51/142 (35.92%), Postives = 72/142 (50.70%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Match: sp|Q62829|PAK3_RAT (Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus OX=10116 GN=Pak3 PE=1 SV=1)

HSP 1 Score: 488.034 bits (1255), Expect = 4.177e-162
Identity = 244/354 (68.93%), Postives = 287/354 (81.07%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S+    +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  191 IAPRPEHTKSIYTRSVVESIASPAAPNKEATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLILAAKE 537

HSP 2 Score: 76.2554 bits (186), Expect = 6.315e-13
Identity = 51/127 (40.16%), Postives = 72/127 (56.69%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Match: sp|Q61036|PAK3_MOUSE (Serine/threonine-protein kinase PAK 3 OS=Mus musculus OX=10090 GN=Pak3 PE=1 SV=2)

HSP 1 Score: 486.878 bits (1252), Expect = 1.504e-161
Identity = 244/354 (68.93%), Postives = 286/354 (80.79%), Query Frame = 3 
Query: 1242 IADRPEKTKSIYTKPIEDKSVAVHSP-------------SAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            IA RPE TKSIYT+ + +   +  +P             S     +   Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  ++ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:  206 IAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLIIAAKE 552

HSP 2 Score: 65.855 bits (159), Expect = 1.022e-9
Identity = 51/142 (35.92%), Postives = 72/142 (50.70%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFA---------------GVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G   K +       P IS P    H +H+ F   TGEF                G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYM 153
[Close]
BLAST of P21 activated kinase-1 vs. TrEMBL
Match: I1ZID6 (p21 activated kinase-1 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 853.973 bits (2205), Expect = 0.000e+0
Identity = 446/448 (99.55%), Postives = 446/448 (99.55%), Query Frame = 3 
Query:  942 FSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            FSNGNGFNFNINNAISTKEYSCTLEIQE NLLNTED NDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH
Sbjct:    1 FSNGNGFNFNINNAISTKEYSCTLEIQEANLLNTEDSNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 448
[Close]
BLAST of P21 activated kinase-1 vs. TrEMBL
Match: G4M138 (Serine/threonine kinase OS=Schistosoma mansoni OX=6183 GN=Smp_179800 PE=4 SV=1)

HSP 1 Score: 522.702 bits (1345), Expect = 7.862e-173
Identity = 244/301 (81.06%), Postives = 272/301 (90.37%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            I EKLR IVS+GDPNRKY++ EKIGQGASGVVY+G+E+STG++VAIKQM LK+QPKKELI+NEI VMK  +HPNVVNYLDSYLVG      DELWVVMEYLDGGSLTEVVTET MDEG IAAVCRECLQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQL+ EQTKRSTMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EMIDGEPPYLNENP+RALYLI TNGKPEIKE+ +LS  FLDFLD+CLEV V+ R SA ELL HPFIVR++KPLSSLTPLI+VA++QA +++ 
Sbjct:  273 IQEKLRMIVSIGDPNRKYQRLEKIGQGASGVVYSGMESSTGRRVAIKQMNLKKQPKKELIVNEIYVMKVKKHPNVVNYLDSYLVG------DELWVVMEYLDGGSLTEVVTETLMDEGQIAAVCRECLQALEFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSAEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSAEFLDFLDRCLEVNVDLRASAFELLKHPFIVRRSKPLSSLTPLILVARDQARNQTQ 567
[Close]
BLAST of P21 activated kinase-1 vs. TrEMBL
Match: A0A183LBG3 (Protein kinase domain-containing protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS1138 PE=4 SV=1)

HSP 1 Score: 520.39 bits (1339), Expect = 1.948e-172
Identity = 244/301 (81.06%), Postives = 272/301 (90.37%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            I EKLR IVS+GDPNRKY+K EKIGQGASGVVY+GIE++TG++VAIKQM LK+QPKKELI+NEI VMK  +HPNVVNYLDSYL+G      DELWVVMEYLDGGSLTEVVTET MDEG IAAVCRECLQAL+FLH N VIHRDIKSDNILLGLDGSVKLTDFGFCAQL+ EQTKRSTMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EMIDGEPPYLNENP+RALYLI TNGKPEIKE+ +LS  FLDFLD+CLEV V+ R SA ELL HPFIVR++KPLSSLTPLI+VA++QA +++ 
Sbjct:  236 IQEKLRMIVSIGDPNRKYQKLEKIGQGASGVVYSGIESTTGRRVAIKQMNLKKQPKKELIVNEIYVMKVKKHPNVVNYLDSYLIG------DELWVVMEYLDGGSLTEVVTETLMDEGQIAAVCRECLQALEFLHKNQVIHRDIKSDNILLGLDGSVKLTDFGFCAQLSPEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIDGEPPYLNENPVRALYLIGTNGKPEIKERDKLSPEFLDFLDRCLEVNVDLRASAFELLKHPFIVRRSKPLSSLTPLILVARDQARNQTQ 530
[Close]
BLAST of P21 activated kinase-1 vs. TrEMBL
Match: V3Z6J3 (Non-specific serine/threonine protein kinase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_179393 PE=3 SV=1)

HSP 1 Score: 513.072 bits (1320), Expect = 4.073e-170
Identity = 266/383 (69.45%), Postives = 311/383 (81.20%), Query Frame = 3 
Query: 1164 KNKLSVKSSDI-----IHNSADNNCIKD----PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            K  L++KSS I     + N+ D N  ++    PPPIA RP++TKSIYTKPIE+       P   + ++ + + KK K++++EI EKLR IV++GDPNRKY K EKIGQGASG VY  IE +TG++VAIK M L QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      +ELWVVME+L GGSLT+VVTET MDEG I+AVCRECLQAL+FLH N VIHRDIKSDNILLG+DGSVKLTDFGFCAQL+ EQ+KRSTMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNGKP+IKEK +LS VF DFLDKCL+V VEKR SASELL HPF+ R AKPL+SL PLI+ AKE  A + H
Sbjct:  128 KYMLNIKSSTISKPENLANAGDVNDAENAESPPPPIAARPDRTKSIYTKPIEE-----DKPHDTSHDNKTEKPKKKKMTDDEIMEKLRSIVTIGDPNRKYTKMEKIGQGASGTVYIAIEVATGREVAIKTMNLSQQPKKELIINEILVMRENQNPNIVNYLDSYLVG------EELWVVMEFLAGGSLTDVVTETCMDEGQISAVCRECLQALEFLHENQVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQSKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGKPDIKEKQKLSPVFQDFLDKCLDVDVEKRASASELLKHPFL-RLAKPLASLVPLILAAKE--AQKGH 496

HSP 2 Score: 69.3218 bits (168), Expect = 2.154e-8
Identity = 50/130 (38.46%), Postives = 74/130 (56.92%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQN-SENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENN-ISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDL 824
            PAPP+R  S    + S+ +   KPLP  P  + K K++K    GK  +         P IS P +  H VH+ F   TGEF G+P  W  +L+N+ I+K EQ++NP+AVL+ LN    K+K + KYM+++
Sbjct:   13 PAPPVRLESTRESSLSQEY---KPLPKEPDEKKKFKNQKGNKTGKQKENEK------PVISEPKNFEHMVHVGFDCHTGEFTGMPESWAKLLQNSTITKSEQKKNPQAVLDVLNYYDSKDKRESKYMLNI 133
[Close]
BLAST of P21 activated kinase-1 vs. TrEMBL
Match: R7V8P5 (Non-specific serine/threonine protein kinase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_219445 PE=4 SV=1)

HSP 1 Score: 512.686 bits (1319), Expect = 1.412e-169
Identity = 257/351 (73.22%), Postives = 294/351 (83.76%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            PPPIA RPEKTKSIYTKP+E+         A        ++KK K+++EEI EKLR IVS+GDPNRKY K +KIGQGASG VY  +E +TG +VAIKQM L QQPKKELIINEI VM+ N++PN+VNYLDS+LVG      +ELWV+MEYLDGGSLT+VVTET MDEG IAAVCRECLQAL+FLH N+VIHRDIKSDNILLG+DGSVKLTDFGFCAQL  EQ KRSTMVGTPYWMAPEVVTRKQYGPKVD+WSLGIMA+EMIDGEPPYLNENPLRALYLIATNGKP+IK+K +LS VF DFLD+CL+ +V+ R SA+ELL HPF+ R AKPL+SLTPLI+ AKE  AS+ H
Sbjct:  187 PPPIATRPEKTKSIYTKPVEEDKAKSAGQKA-------DRQKKKKMTDEEILEKLRTIVSIGDPNRKYTKMDKIGQGASGTVYIALEIATGHEVAIKQMNLSQQPKKELIINEILVMRENKNPNIVNYLDSFLVG------EELWVIMEYLDGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHENHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLLPEQNKRSTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIDGEPPYLNENPLRALYLIATNGKPDIKDKHKLSTVFQDFLDRCLDCEVDTRYSATELLRHPFL-RLAKPLASLTPLILAAKE--ASKGH 521

HSP 2 Score: 63.929 bits (154), Expect = 1.201e-6
Identity = 33/73 (45.21%), Postives = 46/73 (63.01%), Query Frame = 3 
Query:  609 PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNIL--VDKNKNKEKYMM 818
            P IS P +  H VH+ F   TGEF G+P  W  +L+ +NISK+EQ++NP+AVL+ LN      K   + KYM+
Sbjct:   86 PVISPPSNFEHTVHVGFDAHTGEFTGMPESWARLLQTSNISKVEQKKNPQAVLDVLNYYDTSTKQATESKYMI 158
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Match: pak2a (p21 protein (Cdc42/Rac)-activated kinase 2a [Source:ZFIN;Acc:ZDB-GENE-021011-2])

HSP 1 Score: 461.07 bits (1185), Expect = 8.960e-152
Identity = 232/349 (66.48%), Postives = 285/349 (81.66%), Query Frame = 3 
Query: 1233 PPPI-ADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXX----XXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PPPI A RPE TKS+ T+P     + + + SA +  S ++ ++K     K+++EEI EKLR IVS+GDP +KY ++EKIGQGASG V+  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+LVG      +EL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS +F DFL++CLE+ VEKR    ELL HPF+ + AKPLSSLTPLI+ AK+
Sbjct:  265 PPPIVAPRPEHTKSVLTRPSMIDPLPLPAASADSDASRAADRQKKNPKGKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVG------EELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGGGKELLQHPFL-KLAKPLSSLTPLILAAKD 606

HSP 2 Score: 65.0846 bits (157), Expect = 2.185e-10
Identity = 43/129 (33.33%), Postives = 66/129 (51.16%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFN-ISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCI--PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNKNKEKYM 815
            P PP+R +S   ++    N  SKPLP +P  +   ++K       + K           P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K EQ++NP+AVL+ L         K+KY+
Sbjct:  104 PPPPVRMSSTGSKDGAPTNHSSKPLPSVPEEKKPSRNKIISIIFPAEKGGRKKDKDKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGKQKYL 232
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Match: pak2b (p21 protein (Cdc42/Rac)-activated kinase 2b [Source:ZFIN;Acc:ZDB-GENE-030131-3759])

HSP 1 Score: 452.21 bits (1162), Expect = 4.379e-150
Identity = 213/294 (72.45%), Postives = 253/294 (86.05%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            I +KLR IVS+GDP +KY ++EKIGQGASG VY  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+LVG      +EL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS +F DFL +CLE+ VEKR S+ ELL HPF+ + AKPLSSLTPLI+ AK+
Sbjct:  197 IMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVG------EELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPEKLSPIFRDFLARCLEMDVEKRGSSKELLQHPFL-KLAKPLSSLTPLILAAKD 483
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 453.366 bits (1165), Expect = 5.969e-150
Identity = 237/362 (65.47%), Postives = 277/362 (76.52%), Query Frame = 3 
Query: 1197 IHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVH------SPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            +    D N    PP IA RPE TKS+ T  I      ++      +PS+     ++ + +K K+S+EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N+          YLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE
Sbjct:  173 VSEDEDENEAAPPPVIAPRPEHTKSVSTSYIYISLTHINGGSPTPTPSS-TAPRSADKTRKKKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK---------PYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSVFRDFLNRCLEMDVEKRGSAKELLQHQFL-KVAKPLSSLTPLILAAKE 517

HSP 2 Score: 69.3218 bits (168), Expect = 8.717e-12
Identity = 50/132 (37.88%), Postives = 71/132 (53.79%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSEN-----FNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDK-NKNKEKYM 815
            PAPP+R TS +   S        + SKPLP  P+ EDKK+  +S     +        P    IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPMRNTSTMMGASSKDPGPLNHSSKPLP--PNPEDKKRKDRSIRSILTGANKKKERP---EISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETANSQKYM 138
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Match: pak1 (p21 protein (Cdc42/Rac)-activated kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030826-29])

HSP 1 Score: 441.039 bits (1133), Expect = 1.238e-145
Identity = 230/355 (64.79%), Postives = 264/355 (74.37%), Query Frame = 3 
Query: 1212 DNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVH-SPSAIXXXXXXXXXXXXXXXXXXICEK---LRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            D N    PP IA RPE TKS+ T  I      ++ SP        S       L  + +C     +  IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N+          YLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EMI+GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE
Sbjct:  153 DENEAAPPPVIAPRPEHTKSVSTSYIYISLTHINLSPPPCCPTCISYSLILLLLFSDCLCVSCVFIGSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK---------PYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSVFRDFLNRCLEMDVEKRGSAKELLQHQFL-KVAKPLSSLTPLILAAKE 491

HSP 2 Score: 67.0106 bits (162), Expect = 4.698e-11
Identity = 46/132 (34.85%), Postives = 68/132 (51.52%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSEN-----FNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDK-NKNKEKYM 815
            PAPP+R TS +   S        + SKPLP  P ++ +K              ++      P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPMRNTSTMMGASSKDPGPLNHSSKPLPPNPEDKKRKDRSIRSILTGGGDKTNKKKE-RPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETANSQKYM 142
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Match: PAK3 (p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592])

HSP 1 Score: 403.29 bits (1035), Expect = 7.734e-131
Identity = 218/361 (60.39%), Postives = 249/361 (68.98%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTK-----------------PIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+                 P E +     + S+        Q+KKSK+++EEI E+LR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLR                                              H F+ + AKPLSSLTPLIV AKE
Sbjct:  192 PPIIAPRPEHTKSIYTRSVIEPAAPPAPVKEVTTPPESQVQPEDTTSSTLYRHTDRQRKKSKMTDEEILERLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR----------------------------------------------HSFL-KLAKPLSSLTPLIVAAKE 499

HSP 2 Score: 68.5514 bits (166), Expect = 1.678e-11
Identity = 49/138 (35.51%), Postives = 75/138 (54.35%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            M+ S  ++   PAPPLR +S    +S +   SKPLP+ P  ++KK  +         K +       P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AV++ L     K   N +KYM
Sbjct:    1 MSDSVDIEEKPPAPPLRMSSSSRDSSLH--SSKPLPMAPEEKNKKSARLRSIFPGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVIDVLKFYDSKETVNNQKYM 136
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 306.22 bits (783), Expect = 1.603e-92
Identity = 144/285 (50.53%), Postives = 203/285 (71.23%), Query Frame = 3 
Query: 1395 LRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLI 2249
            L+++V  GDP+   +   KIG+G++GVV   ++  +G++VA+K+M L++Q ++EL+ NE+ +M+   H NVV+  +SYLV      ADELWVVME+L+GG+LT++VT T M+E  IA VC   L+AL +LH   VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E T+R ++VGTPYWMAPEV++R  YGP+VDVWSLGIM +EM+DGEPPY NE PL+A+  I  N  P++K   + S +   FLD+ L      R +A ELL HPF+ + A P + + PL+
Sbjct:  406 LQQVVDPGDPSEYLENFIKIGEGSTGVVCLAVDRRSGRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLV------ADELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQVSKEVTRRKSLVGTPYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFL-QNAGPPACIVPLM 683
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 225.328 bits (573), Expect = 1.520e-65
Identity = 123/283 (43.46%), Postives = 167/283 (59.01%), Query Frame = 3 
Query: 1410 SLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIIN-EICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIK--SDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLI 2249
            S  DP   + K E+IG+G+ G V+ GI+  T + VAIK + L++   +   I  EI V+     P V +Y  SYL G       +LW++MEYL GGS  +++    ++E  IA + RE L+ LD+LH+   IHRDIK  + N+LL   G VKL DFG   QL + Q KR+T VGTP+WMAPEV+ +  Y  K D+WSLGI A+E+  GEPP    +P+R L+LI  N  P +  +   S  F +F+D CL    + R +A ELL H FI R AK  S LT LI
Sbjct:   18 SCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKG------TKLWIIMEYLGGGSALDLIKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTL--EGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELI 292
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Match: myo3a (myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4])

HSP 1 Score: 201.445 bits (511), Expect = 1.921e-53
Identity = 111/289 (38.41%), Postives = 163/289 (56.40%), Query Frame = 3 
Query: 1392 KLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIK------QMQLKQQPKKELIINEICVMKA-NRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETF-----MDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQ-----YGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI 2207
            KL K   L DP+  ++  E IG+G  G VY       G K A+K       ++   Q   E I  E  ++ +   HPN+V +   Y     G   D+LW+V+E  +GGS+T++V         MD   IA + R  L  L+ LH++N+IHRDIK +NILL  DG ++L DFG  AQ++  + +R+T VGTP+WMAPEV+  +Q     Y  + DVWS+GI A+E+ DG+PP    +P+RAL+ I  N  P +K+      +F +F+ +CL    E+R + S+LL  PFI
Sbjct:   10 KLIKFEQLKDPSDTWELVETIGKGTYGKVYKATSRKDGSKAAVKTLDPVNNLETSNQDIDEEIEAEYSILTSLPEHPNIVRFFGMY-YQKDGVNGDQLWIVLELCNGGSVTDLVKGQLKRGERMDVMLIAYILRGALLGLNHLHSHNIIHRDIKGNNILLTTDGGIRLVDFGVSAQVSKTRVERNTAVGTPFWMAPEVIACEQQLDYMYDRRCDVWSMGITAIELGDGDPPLYELHPMRALFKIPRNPPPTLKQPELWPPLFNEFIAQCLVKDFERRATVSQLLEDPFI 297
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 197.593 bits (501), Expect = 1.007e-52
Identity = 112/278 (40.29%), Postives = 166/278 (59.71%), Query Frame = 3 
Query: 1446 EKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETF-MDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEV--VTRK-QYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNG--KPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAK 2261
            E++G G  G V+      TG+ VAIK ++L+      +I  EI +MK  +H N+V Y  SYL        D+LW+ ME+  GGSL ++   T  + E  IA V RE LQ L +LH+   +HRDIK  NILL  DG VKL DFG  AQ+     KR + +GTPYWMAPEV  V RK  Y  + DVW++GI A+E+ + +PP  + +P+RAL+L++ +G   P++++K + S VF +F+   L    +KR +A ++LTH ++    +PLS    L ++ +
Sbjct:   18 ERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLR------HDKLWICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYV---QQPLSRAQALELLER 286
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 195.667 bits (496), Expect = 1.286e-51
Identity = 114/306 (37.25%), Postives = 165/306 (53.92%), Query Frame = 3 
Query: 1395 LRKIVSLGDPNRKYKKHE----------------KIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTE--TFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVV---TRKQ--YGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI--VRKAKPLSSL 2237
             RKI  LG   RK K+++                ++G GA G VY      +G   A K ++ K + + E  + EI ++    HPN+V  L+++         ++LW+ +E+  GG++  ++ E    + E  I  VC++ L+AL++LHT+ +IHRD+K+ NILL  +G VKL DFG  A+      +R + +GTPYWMAPEVV   T K   Y  K D+WSLGI  +E+   EPP    NP+R +  IA N  P +   S+ S  F DFL KCL+   E R +A +LL H FI  V   KPL  L
Sbjct:    4 FRKIFKLGSERRKPKQYDHVRRDVDPAELWSVIGELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAFYY------ENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFISGVDSNKPLREL 303
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 386.341 bits (991), Expect = 3.510e-120
Identity = 181/290 (62.41%), Postives = 220/290 (75.86%), Query Frame = 3 
Query: 1392 KLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAK 2261
            KL +I S GDP+ KY    KIGQGASG VY   E  T   VAIKQM L++QPKKELIINEI VMK ++HPN+VN++DSY++ G      +LWV+MEY++GGSLT+VVT   + EG I AVCRE L  L+FLH+  V+HRDIKSDNILL ++G +KLTDFGFCAQ+N    KR+TMVGTPYWMAPEVV+RK+YGPKVD+WSLGIM +EMI+GEPPYLNE PLRALYLIATNG P++KE   LS     FLD CL V+ E R SA+ELL   +I   A+  SSL PL+ +A+
Sbjct:  606 KLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKG------DLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVKLAR 889

HSP 2 Score: 49.2914 bits (116), Expect = 2.774e-6
Identity = 24/59 (40.68%), Postives = 35/59 (59.32%), Query Frame = 3 
Query:  615 ISAPISVMHKVHITFSQDTGEFAGVPLEWQVIL-ENNISKIEQQQNPRAVLNALNILVD 788
            IS P +  H  H+     TGE+ G+P EW+ +L  + ISK EQQQN +AV++ +    D
Sbjct:  337 ISTPYNAKHIHHVGVDSKTGEYTGLPEEWEKLLTSSGISKREQQQNMQAVMDIVKFYQD 395
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 310.071 bits (793), Expect = 8.744e-93
Identity = 160/314 (50.96%), Postives = 207/314 (65.92%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVY------------------NGI-ETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVV--------TETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKP--LSSL 2237
            I  KL+K+    DP++ +K  EK GQGASG VY                  N I E   G KVAIKQM L +QP+KELI+NEI VMK +RH N+VN+L++YL        D+LWVVME+++GGSLT+++        + + + E  IA + RE  Q L FLH  ++IHRDIKSDN+LL     VK+TDFGFCA+L ++++KR+TMVGTPYWMAPEVV +++Y  K+DVWSLGIM +EM++GEPPYLNE+PL+ALYLIATNG P++K    LS+    FL  CL V V  R S  ELL H F      P  L+SL
Sbjct:  529 IMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYL-----RTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSL 837
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473])

HSP 1 Score: 286.189 bits (731), Expect = 1.039e-85
Identity = 142/308 (46.10%), Postives = 196/308 (63.64%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVY-----------------NGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETF----------MDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKP 2225
            I  K++ +    +P   ++  EK GQGASG VY                 +      G++VAIKQ++L +QPKK+LI+NE+ VM  +R  N+VN+L++Y++       +ELWV+MEY++GG LT+++              ++E  +A + +E  Q L FLH   +IHRDIKSDNILL   G VK+TDFGFC +L  +++KR+TMVGTPYWMAPE+V +K Y  KVDVWSLGIM +EMI+GEPPYLNE+PL+ALYLIA NG P+++    +S     FLD CL+V VE R S  +LLT  F+     P
Sbjct:  343 IIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDD-----EELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSP 645

HSP 2 Score: 48.9062 bits (115), Expect = 3.482e-6
Identity = 23/66 (34.85%), Postives = 36/66 (54.55%), Query Frame = 3 
Query:  600 PCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKN 794
            P +  +S+P +  HKVH+ F    G F GVP  W  +L+ + I+  +  +N +AV+ AL    D N
Sbjct:  118 PLLSGVSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYN 183
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 201.06 bits (510), Expect = 1.122e-53
Identity = 113/276 (40.94%), Postives = 159/276 (57.61%), Query Frame = 3 
Query: 1434 YKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKK-ELIINEICVMKANRH-PNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRK-QYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI-VRKAKPLSSLTPLI 2249
            +K+ E IG+G  GVVY G    TG+  AIK + L     + E +  EI  + + +   N+  Y  SYL   +      LW++ME+  GGSL  ++    +DE +I  + RE L AL  +H +NVIHRDIK+ N+L+  +G+VKL DFG  AQ+N    +R TM GTPYWMAPEV+     Y  KVD+WSLGI   E+  G PPY +   LRA+ LI  +  P ++++S  S    +F+  CL+   ++R+SA +LL   FI   KA P S L  LI
Sbjct:   23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTS------LWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELI 291
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 162.925 bits (411), Expect = 2.733e-41
Identity = 97/271 (35.79%), Postives = 154/271 (56.83%), Query Frame = 3 
Query: 1434 YKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQL-KQQPKKELIIN-------EICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVV-TETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRS-TMVGTPYWMAPEVVTRKQ-YGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIA-TNGKPEIKEKS--RLSVVFLDFLDKCLEVQVEKRISASELLTHPF 2204
            + K E IG+G+ G VY  +  +TG+ +A+KQ+++ K   + E I++       E+  +K   H N+V YL      G     +   + +EY+ GGS+  ++      DE  I  +  + L+ L +LH+  ++HRD+K+DN+LL  DG  K++DFG   +  +  +    TM GT +WMAPE+V  KQ Y  KVD+WSLG + LEM  G+ P+ N   + A++ I  +   P I E +   +S +  +FLD C E+  EKR +A+ELL+HPF
Sbjct: 1175 WMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYL------GFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0])

HSP 1 Score: 470.7 bits (1210), Expect = 2.026e-157
Identity = 245/366 (66.94%), Postives = 280/366 (76.50%), Query Frame = 3 
Query: 1197 IHNSADNNCIKD---PPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            I     +N + D   PP I  RPE TKS   KP   +  A               K+K K+S+EEI  +LR IVS+GDP +KY K EKIGQGASG VY  IE +TG +VAIKQM L QQPKKELIINEI VM+ N+HPN+VNY+DSYLVG      +ELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQAL+FLH+N VIHRDIKSDNILLG+DG VKLTDFGFCA +  EQ KRSTMVGTPYWMAPEVVTRKQYGP+VDVWSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE+    +LS VF DFL + LE+ VEKR SA ELL HPF+ ++AKPL+SL PLI+ AKE A SR+H
Sbjct:  160 ITEHGSSNSVNDDAQPPAIPSRPEHTKS---KPSHGQVQA-------------RDKRKKKMSDEEILARLRTIVSIGDPKKKYTKFEKIGQGASGTVYTAIEVATGHEVAIKQMNLSQQPKKELIINEILVMRENKHPNIVNYVDSYLVG------EELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATITPEQNKRSTMVGTPYWMAPEVVTRKQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFL-KQAKPLASLVPLILAAKE-ATSRAH 501

HSP 2 Score: 67.781 bits (164), Expect = 9.265e-12
Identity = 47/122 (38.52%), Postives = 68/122 (55.74%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNKNK 803
            PAPP+R TS   +++ N   SKPLP  P  E KKK    +      + +    P    IS P    H +H+ F   TGEF G+P  W  +L+ +NI++ EQ++NP+AVL+ LN   D +K+K
Sbjct:    8 PAPPIRLTS---KDASNSLGSKPLPNAPVEEKKKKTATFRLFPNKTEYNKKNKP---EISYPTQFEHTIHVGFDPVTGEFTGMPEAWARLLQVSNITQAEQKKNPQAVLDVLN-FYDSSKDK 122
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1])

HSP 1 Score: 278.87 bits (712), Expect = 8.232e-87
Identity = 131/253 (51.78%), Postives = 179/253 (70.75%), Query Frame = 3 
Query: 1449 KIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI 2207
            KIG+G++G+V    +  TG++VA+K+M LK+Q ++EL+ NE+ +M+   HPN+V    S+LVG      DELWVVME+L+GG+LT++VT T + E  +A VCR  L+AL FLH+  VIHRDIKSD+ILL  +G+VKL+DFGFCAQ+  +  +R ++VGTPYWMAPEV++RK YG +VD+WSLGIM LEM+DGEPPY NE PL+A+  +     P  +   ++S     FLD  L      R +A ELL HPFI
Sbjct:   34 KIGEGSTGIVCLATDKRTGRQVAVKKMDLKKQQRRELLFNEVVIMRDYPHPNIVEMYGSHLVG------DELWVVMEFLEGGTLTDIVTHTNLSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCAQVTEDMPRRKSLVGTPYWMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQAMRKLRDLEPPTSRNPIQISPRLQSFLDNALIRDPLYRATAFELLNHPFI 280
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 208.379 bits (529), Expect = 1.576e-60
Identity = 110/278 (39.57%), Postives = 165/278 (59.35%), Query Frame = 3 
Query: 1422 PNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEV--VTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLI 2249
            P   +   EK+G+G+ G V+  +   +G+ VAIKQ+ +    ++  II EI +M+    P VV Y  SY          +LW+VMEY   GS++++  +    + E  I  V +  L+ L++LH    IHRDIK+ NILL  +G  KL DFG   QL +   KR+T++GTP+WMAPEV+    Y    D+WSLGI A+EM +G+PPY + +P+RA+++I T   P  ++  + S  F DF+ KCL    E+R +A+ELL H FI + AK +S L+ +I
Sbjct:   20 PEEVFDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPVDTDLQE--IIKEISMMQQCDSPYVVKYYGSYFKN------TDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFI-QGAKQISILSSMI 288
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 209.149 bits (531), Expect = 6.121e-60
Identity = 116/279 (41.58%), Postives = 163/279 (58.42%), Query Frame = 3 
Query: 1416 GDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIIN-EICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLI 2249
             DP + + K E+IG+G+ G V+ GI+  T + VAIK + L++   +   I  EI V+       V  Y  SYL G       +LW++MEYL GGS  +++    ++E +IA + RE L+ LD+LHT   +HRDIK+ N+L+   G VKL DFG   QL +   KR+T VGTP+WMAPEV+ +  Y  K D+WSLGI A+E+  GEPP  + +P+R L+LI  N  PE+      S  F +F+  CL      R +A ELL H FI + AK  + L  LI
Sbjct:    5 ADPEKLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKG------TKLWIIMEYLGGGSALDLMKAGNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPEL--TGNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFI-KTAKKNAYLVELI 274
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1])

HSP 1 Score: 198.364 bits (503), Expect = 4.838e-57
Identity = 108/279 (38.71%), Postives = 162/279 (58.06%), Query Frame = 3 
Query: 1395 LRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETF-MDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQ---YGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNG--KPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVR 2213
            LR  +S G+P++ +   EK+G G  G V+     +TG   A+K ++++     ELI  EI +M+  RH N++NY+ +Y+        D+LW+ MEY  GGS+ +V   T    E  I+ V  E L+ L +LH  +++HRDIK  NILL  +G VKL DFG  A++     KR + +GTPYWMAPE+   ++   Y  K D+W++GI A+EM + +PP  + +P+RALY+I       P +KEK + S     F+   L    +KR SA ++LTHPF  R
Sbjct:    5 LRAQISRGNPDKVFDLIEKVGGGTYGDVFKARVIATGDLAAVKVVKVEPGDDFELIQQEIAMMQQCRHNNIINYIGAYMR------RDKLWIGMEYCGGGSIQDVYCVTGPCSETQISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITAIEMAELQPPMFDLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKNPKKRPSADKMLTHPFCCR 277
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Match: PAK3 (serine/threonine-protein kinase PAK 3 [Source:NCBI gene;Acc:101162700])

HSP 1 Score: 479.559 bits (1233), Expect = 1.243e-159
Identity = 245/360 (68.06%), Postives = 283/360 (78.61%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIED----------------KSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + D                  V   + S         Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++ N+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA +LL H F+ + AKPLSSLTPLI+ AKE
Sbjct:  196 PPVIAPRPEHTKSIYTRSVMDPPKPPSPVKEVVTPPESQVQPENTSNTMYRHTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNSNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSSVFRDFLNRCLEMDVDRRGSAKDLLQHSFL-KLAKPLSSLTPLILAAKE 548

HSP 2 Score: 70.8626 bits (172), Expect = 3.828e-12
Identity = 61/182 (33.52%), Postives = 88/182 (48.35%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFS 947
            M+ S  ++   PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G             P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AV++ L     K   N +KYM         S  S D+T     +       +S S D P  P  S
Sbjct:    1 MSDSVDIEEKPPAPPLRMNSSSRDSSSVNHASKPLPMAPEEKNKKVRLRSIFPGGDKTNKKKEKER-PEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVIDVLKFYDSKETVNNQKYM---------SFTSGDKTAHGYIAANTLGAKTSSSTDPPIAPPVS 172
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Match: PAK3 (serine/threonine-protein kinase PAK 3 [Source:NCBI gene;Acc:101162700])

HSP 1 Score: 479.945 bits (1234), Expect = 1.660e-159
Identity = 245/360 (68.06%), Postives = 283/360 (78.61%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIED----------------KSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + D                  V   + S         Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++ N+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA +LL H F+ + AKPLSSLTPLI+ AKE
Sbjct:  217 PPVIAPRPEHTKSIYTRSVMDPPKPPSPVKEVVTPPESQVQPENTSNTMYRHTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNSNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSSVFRDFLNRCLEMDVDRRGSAKDLLQHSFL-KLAKPLSSLTPLILAAKE 569

HSP 2 Score: 69.707 bits (169), Expect = 7.096e-12
Identity = 51/138 (36.96%), Postives = 75/138 (54.35%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            M+ S  ++   PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G             P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AV++ L     K   N +KYM
Sbjct:    1 MSDSVDIEEKPPAPPLRMNSSSRDSSSVNHASKPLPMAPEEKNKKVRLRSIFPGGDKTNKKKEKER-PEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVIDVLKFYDSKETVNNQKYM 137
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Match: PAK3 (serine/threonine-protein kinase PAK 3 [Source:NCBI gene;Acc:101162700])

HSP 1 Score: 479.945 bits (1234), Expect = 1.660e-159
Identity = 245/360 (68.06%), Postives = 283/360 (78.61%), Query Frame = 3 
Query: 1233 PPPIADRPEKTKSIYTKPIED----------------KSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            PP IA RPE TKSIYT+ + D                  V   + S         Q+KKSK+++EEI EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++ N+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDEG IAAVCRECLQALDFLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   RLS VF DFL++CLE+ V++R SA +LL H F+ + AKPLSSLTPLI+ AKE
Sbjct:  217 PPVIAPRPEHTKSIYTRSVMDPPKPPSPVKEVVTPPESQVQPENTSNTMYRHTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNSNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQNKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSSVFRDFLNRCLEMDVDRRGSAKDLLQHSFL-KLAKPLSSLTPLILAAKE 569

HSP 2 Score: 69.707 bits (169), Expect = 7.096e-12
Identity = 51/138 (36.96%), Postives = 75/138 (54.35%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDKNK-NKEKYM 815
            M+ S  ++   PAPPLR  S    +S   + SKPLP+ P  ++KK   +S F G             P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AV++ L     K   N +KYM
Sbjct:    1 MSDSVDIEEKPPAPPLRMNSSSRDSSSVNHASKPLPMAPEEKNKKVRLRSIFPGGDKTNKKKEKER-PEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVIDVLKFYDSKETVNNQKYM 137
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Match: pak1 (p21 (RAC1) activated kinase 1 [Source:NCBI gene;Acc:101164663])

HSP 1 Score: 468.774 bits (1205), Expect = 2.409e-155
Identity = 222/296 (75.00%), Postives = 254/296 (85.81%), Query Frame = 3 
Query: 1383 ICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQA 2270
            I EKLR IVS+GDP +KY + EKIGQGASG VY  I+ +TG++VAIKQM L+QQPKKELIINEI VM+ N++PN+VNYLDSYLVG      DELWVVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH+N VIHRDIKSDNILLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK Y PKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS +F DFL++CLE+ VEKR SA ELL H F+ + AKPLSSLTPLI+ AKE A
Sbjct:  271 ILEKLRTIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYCPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSTIFRDFLNRCLEMDVEKRGSAKELLQHQFL-KMAKPLSSLTPLILAAKEAA 559

HSP 2 Score: 69.3218 bits (168), Expect = 9.386e-12
Identity = 48/132 (36.36%), Postives = 71/132 (53.79%), Query Frame = 3 
Query:  441 PAPPLRTTSVIHQNSENFNI-----SKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILE-NNISKIEQQQNPRAVLNALNILVDK-NKNKEKYM 815
            PAPP+R TS +  +     +     SKPLP  P ++  KKD+  +F        +      P IS P    H +H+ F   TGEF G+P +W  +L+ +NI+K+EQ++NP+AVL+ L     K   N +KYM
Sbjct:   12 PAPPMRNTSTMIGSCNKDAVPLNHGSKPLPPNPEDKKNKKDRSIRFILTGGGDKTYKKKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETSNSQKYM 143
[Close]
BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Match: pak2b (p21 (RAC1) activated kinase 2 [Source:NCBI gene;Acc:101167280])

HSP 1 Score: 457.218 bits (1175), Expect = 5.373e-153
Identity = 231/338 (68.34%), Postives = 276/338 (81.66%), Query Frame = 3 
Query: 1257 EKTKSIYTKP-IEDKSVAVHSPSA-IXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKE 2264
            E TKS+YT+  IE    A   P       +   QKKKSK+++EEI +KLR IVS+GDP +KY ++EKIGQGASG V+  I+ +TG++VAIKQ+ L++QPKKELIINEI VMK  ++PN+VN+LDS+L+G      DEL+VVMEYL GGSLT+VVTET MDE  IAAVCRECLQAL+FLH N VIHRDIKSDN+LLG+DGSVKLTDFGFCAQ+  EQ+KRSTMVGTPYWMAPEVVTRK YGPKVD+WSLGIMA+EM++GEPPYLNENPLRALYLIATNG PE++   +LS VF DFL++CLE+ VEKR    ELL HPF+ + AKPLSSLTPLI+ AKE
Sbjct:   87 EHTKSVYTRSVIEPIPAASTGPDGDAASKAADRQKKKSKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLMG------DELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFRDFLNRCLEMDVEKRGGGKELLQHPFL-KLAKPLSSLTPLILAAKE 417
[Close]
BLAST of P21 activated kinase-1 vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 1164.06 bits (3010), Expect = 0.000e+0
Identity = 624/626 (99.68%), Postives = 624/626 (99.68%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTED NDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNS DNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH
Sbjct:    1 MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTEDSNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSTDNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 626
[Close]
BLAST of P21 activated kinase-1 vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 1159.05 bits (2997), Expect = 0.000e+0
Identity = 624/627 (99.52%), Postives = 624/627 (99.52%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNS-ENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            MNPSQALDLSTPAPPLRTTSVIHQNS ENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTED NDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNS DNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH
Sbjct:    1 MNPSQALDLSTPAPPLRTTSVIHQNSSENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTEDSNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSTDNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 627
[Close]
BLAST of P21 activated kinase-1 vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 1150.58 bits (2975), Expect = 0.000e+0
Identity = 623/633 (98.42%), Postives = 623/633 (98.42%), Query Frame = 3 
Query:  408 MNPSQALDLSTPAPPLRTTSVIHQNS-ENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRS------TGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
            MNPSQALDLSTPAPPLRTTSVIHQNS ENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTN S      TGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTED NDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNS DNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH
Sbjct:    1 MNPSQALDLSTPAPPLRTTSVIHQNSSENFNISKPLPLIPSNEDKKKDKKSKFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNSSSDSAGSTGSTDRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSCTLEIQETNLLNTEDSNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTHTIKNKLSVKSSDIIHNSTDNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 633
[Close]
BLAST of P21 activated kinase-1 vs. Planmine SMEST
Match: SMESG000021793.1 (SMESG000021793.1)

HSP 1 Score: 632.869 bits (1631), Expect = 0.000e+0
Identity = 357/623 (57.30%), Postives = 436/623 (69.98%), Query Frame = 3 
Query:  432 LSTPAPPLRTTSV--IHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGN-SSPSQDIPSVPTFSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSY--NHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
             +TPAPPLRTTS   I+ +  +F++ KPLP IP ++D+K+++K K K K  K  +     +PNISAPISV HK+HITF  +TGEF G+P EW  +LE+NISK+EQQQNP AV++ALN   DKN  K+K+M      T     + ++T S S S  GDD    SP+       T S+ +           TKE     +   +N  +   F       ++     ++SQL  N +  ++    +TP +T         S I      +N + +PPPI+ RPEKTKSIYTKPIE+      S S ++       K+K+++S+E+I EK+R IVSLGDP RKY+  E+IGQGASG+V +GIE STGKKVAIKQM LK QPKKEL+INEI VMKAN HPN+VNYLDSYL+       DELWVVMEYLDGGSLTEVVTET+M+EGHIAAV RECLQAL FLH   VIHRDIKSDNILLG+DGSVKL DFGFCAQL++EQ KRSTMVGTPYWMAPEVV +KQYGPKVD+WSLGIMA+EMIDGEPPYLNENPLRALYLIATNGKPEIKE+ +LS +F+ FLD  L V VE R SA++LL HPFI + AKPLSSL PLIVVAKEQA  R+ 
Sbjct:   11 FNTPAPPLRTTSSTGINYSDNSFDVKKPLPKIPDDDDRKRERKLKTKAKLQKSKN----TLPNISAPISVTHKLHITFCSETGEFTGMPPEWMRMLEDNISKVEQQQNPNAVVSALNFFADKNHTKDKFM------TVEHLLNLNQTSSGSTSFNGDDAAVESPNS------TNSSESLSFHKDLTVAKTKEIPPNFKNSHSNNTHNNFFTTQNNKSNSLNFSNDDSQLFLNSSNLNFPPESVTPANT---------SPIFTKMTPHNLVIEPPPISSRPEKTKSIYTKPIEEIKEPYPS-SQLSPTKIHHIKRKARMSDEQISEKIRAIVSLGDPIRKYELKERIGQGASGIVNSGIEISTGKKVAIKQMNLKSQPKKELLINEIYVMKANHHPNIVNYLDSYLLPH-----DELWVVMEYLDGGSLTEVVTETYMEEGHIAAVSRECLQALKFLHERKVIHRDIKSDNILLGIDGSVKLIDFGFCAQLSSEQMKRSTMVGTPYWMAPEVVAKKQYGPKVDIWSLGIMAIEMIDGEPPYLNENPLRALYLIATNGKPEIKERDKLSSLFISFLDNSLSVDVEMRSSAADLLVHPFIKQCAKPLSSLIPLIVVAKEQALKRNQ 602
[Close]
BLAST of P21 activated kinase-1 vs. Planmine SMEST
Match: SMESG000021793.1 (SMESG000021793.1)

HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0
Identity = 358/637 (56.20%), Postives = 437/637 (68.60%), Query Frame = 3 
Query:  432 LSTPAPPLRTTSV--IHQNSENFNISKPLPLIPSNEDXXXXXXXXXXXXXXXXXXXXXPCI--------------PNISAPISVMHKVHITFSQDTGEFAGVPLEWQVILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGSTDRTPSTSASITGDDGN-SSPSQDIPSVPTFSXXXXXXXXXXXAISTKEYSCTLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSY--NHLTPTHTIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVAVHSPSAIXXXXXXXXXXXXXXXXXXICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFIVRKAKPLSSLTPLIVVAKEQAASRSH 2285
             +TPAPPLRTTS   I+ +  +F++ KPLP IP ++D+K+++K K K  ++ I    S  I              PNISAPISV HK+HITF  +TGEF G+P EW  +LE+NISK+EQQQNP AV++ALN   DKN  K+K+M      T     + ++T S S S  GDD    SP+       T S+ +           TKE     +   +N  +   F       ++     ++SQL  N +  ++    +TP +T         S I      +N + +PPPI+ RPEKTKSIYTKPIE+      S S ++       K+K+++S+E+I EK+R IVSLGDP RKY+  E+IGQGASG+V +GIE STGKKVAIKQM LK QPKKEL+INEI VMKAN HPN+VNYLDSYL+       DELWVVMEYLDGGSLTEVVTET+M+EGHIAAV RECLQAL FLH   VIHRDIKSDNILLG+DGSVKL DFGFCAQL++EQ KRSTMVGTPYWMAPEVV +KQYGPKVD+WSLGIMA+EMIDGEPPYLNENPLRALYLIATNGKPEIKE+ +LS +F+ FLD  L V VE R SA++LL HPFI + AKPLSSL PLIVVAKEQA  R+ 
Sbjct:   11 FNTPAPPLRTTSSTGINYSDNSFDVKKPLPKIPDDDDRKRERKLKTKAIAVLICQEKSSLIDYLEAKLQKSKNTLPNISAPISVTHKLHITFCSETGEFTGMPPEWMRMLEDNISKVEQQQNPNAVVSALNFFADKNHTKDKFM------TVEHLLNLNQTSSGSTSFNGDDAAVESPNS------TNSSESLSFHKDLTVAKTKEIPPNFKNSHSNNTHNNFFTTQNNKSNSLNFSNDDSQLFLNSSNLNFPPESVTPANT---------SPIFTKMTPHNLVIEPPPISSRPEKTKSIYTKPIEEIKEPYPS-SQLSPTKIHHIKRKARMSDEQISEKIRAIVSLGDPIRKYELKERIGQGASGIVNSGIEISTGKKVAIKQMNLKSQPKKELLINEIYVMKANHHPNIVNYLDSYLLPH-----DELWVVMEYLDGGSLTEVVTETYMEEGHIAAVSRECLQALKFLHERKVIHRDIKSDNILLGIDGSVKLIDFGFCAQLSSEQMKRSTMVGTPYWMAPEVVAKKQYGPKVDIWSLGIMAIEMIDGEPPYLNENPLRALYLIATNGKPEIKERDKLSSLFISFLDNSLSVDVEMRSSAADLLVHPFIKQCAKPLSSLIPLIVVAKEQALKRNQ 620
The following BLAST results are available for this feature:
BLAST of P21 activated kinase-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PAK38.954e-16469.83p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
PAK38.954e-16469.83p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
PAK31.202e-16368.91p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
PAK31.202e-16368.91p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
PAK31.202e-16368.91p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak-19.800e-15466.95Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
pak-13.552e-15366.95Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
pak-13.667e-15366.95Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
max-21.575e-11658.64Serine/threonine-protein kinase max-2 [Source:Uni... [more]
max-27.260e-11558.64Serine/threonine-protein kinase max-2 [Source:Uni... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pak4.221e-16078.23gene:FBgn0267698 transcript:FBtr0334539[more]
Pak4.221e-16078.23gene:FBgn0267698 transcript:FBtr0081714[more]
Pak4.221e-16078.23gene:FBgn0267698 transcript:FBtr0081716[more]
Pak4.221e-16078.23gene:FBgn0267698 transcript:FBtr0081715[more]
Pak4.221e-16078.23gene:FBgn0267698 transcript:FBtr0334544[more]
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BLAST of P21 activated kinase-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak11.342e-15776.01p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
pak11.342e-15776.01p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
pak2b5.858e-15567.24p21 protein (Cdc42/Rac)-activated kinase 2b [Sourc... [more]
pak2b5.858e-15567.24p21 protein (Cdc42/Rac)-activated kinase 2b [Sourc... [more]
pak13.684e-15476.12p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
flii2.275e-16268.25FLII actin remodeling protein [Source:Xenbase;Acc:... [more]
flii5.854e-16268.25FLII actin remodeling protein [Source:Xenbase;Acc:... [more]
flii1.152e-16168.25FLII actin remodeling protein [Source:Xenbase;Acc:... [more]
taf37.678e-15768.59TATA-box binding protein associated factor 3 [Sour... [more]
qsox21.879e-15666.48quiescin sulfhydryl oxidase 2 [Source:Xenbase;Acc:... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pak39.900e-16368.93p21 (RAC1) activated kinase 3 [Source:MGI Symbol;A... [more]
Pak39.900e-16368.93p21 (RAC1) activated kinase 3 [Source:MGI Symbol;A... [more]
Pak39.900e-16368.93p21 (RAC1) activated kinase 3 [Source:MGI Symbol;A... [more]
Pak39.900e-16368.93p21 (RAC1) activated kinase 3 [Source:MGI Symbol;A... [more]
Pak32.151e-16268.93p21 (RAC1) activated kinase 3 [Source:MGI Symbol;A... [more]
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BLAST of P21 activated kinase-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q7YQL3|PAK3_PONPY1.324e-16269.83Serine/threonine-protein kinase PAK 3 OS=Pongo pyg... [more]
sp|Q7YQL4|PAK3_PANTR1.324e-16269.83Serine/threonine-protein kinase PAK 3 OS=Pan trogl... [more]
sp|O75914|PAK3_HUMAN1.324e-16269.83Serine/threonine-protein kinase PAK 3 OS=Homo sapi... [more]
sp|Q62829|PAK3_RAT4.177e-16268.93Serine/threonine-protein kinase PAK 3 OS=Rattus no... [more]
sp|Q61036|PAK3_MOUSE1.504e-16168.93Serine/threonine-protein kinase PAK 3 OS=Mus muscu... [more]
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BLAST of P21 activated kinase-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZID60.000e+099.55p21 activated kinase-1 (Fragment) OS=Schmidtea med... [more]
G4M1387.862e-17381.06Serine/threonine kinase OS=Schistosoma mansoni OX=... [more]
A0A183LBG31.948e-17281.06Protein kinase domain-containing protein OS=Schist... [more]
V3Z6J34.073e-17069.45Non-specific serine/threonine protein kinase OS=Lo... [more]
R7V8P51.412e-16973.22Non-specific serine/threonine protein kinase OS=Ca... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak2a8.960e-15266.48p21 protein (Cdc42/Rac)-activated kinase 2a [Sourc... [more]
pak2b4.379e-15072.45p21 protein (Cdc42/Rac)-activated kinase 2b [Sourc... [more]
pak15.969e-15065.47p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
pak11.238e-14564.79p21 protein (Cdc42/Rac)-activated kinase 1 [Source... [more]
PAK37.734e-13160.39p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak41.603e-9250.53p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
stk25a1.520e-6543.46serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
myo3a1.921e-5338.41myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4][more]
MAP4K31.007e-5240.29mitogen-activated protein kinase kinase kinase kin... [more]
slka1.286e-5137.25STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE203.510e-12062.41Cdc42p-activated signal transducing kinase; involv... [more]
CLA48.744e-9350.96Cdc42p-activated signal transducing kinase; member... [more]
SKM11.039e-8546.10Member of the PAK family of serine/threonine prote... [more]
KIC11.122e-5340.94Protein kinase of the PAK/Ste20 family, required f... [more]
BCK12.733e-4135.79MAPKKK acting in the protein kinase C signaling pa... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO336672.026e-15766.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458468.232e-8751.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428451.576e-6039.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319346.121e-6041.58Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490474.838e-5738.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of P21 activated kinase-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PAK31.243e-15968.06serine/threonine-protein kinase PAK 3 [Source:NCBI... [more]
PAK31.660e-15968.06serine/threonine-protein kinase PAK 3 [Source:NCBI... [more]
PAK31.660e-15968.06serine/threonine-protein kinase PAK 3 [Source:NCBI... [more]
pak12.409e-15575.00p21 (RAC1) activated kinase 1 [Source:NCBI gene;Ac... [more]
pak2b5.373e-15368.34p21 (RAC1) activated kinase 2 [Source:NCBI gene;Ac... [more]
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BLAST of P21 activated kinase-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000008326.10.000e+099.68SMESG000008326.1[more]
SMESG000008326.10.000e+099.52SMESG000008326.1[more]
SMESG000008326.10.000e+098.42SMESG000008326.1[more]
SMESG000021793.10.000e+057.30SMESG000021793.1[more]
SMESG000021793.10.000e+056.20SMESG000021793.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30014999
GenBankAFJ24790.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014999 ID=SMED30014999|Name=P21 activated kinase-1|organism=Schmidtea mediterranea sexual|type=transcript|length=2705bp
CGAAAATTTGTGAATATCAATAAATCATCTGATTAATAGTCATAAATAAA
ATAAATTATTTATGTCATTATATAAAAATTGTAGAGAATTAAACTCTACA
AAATCACTTCAATCTTTTAATTTGATGTGTTAATCATATGTCGAAACGCA
AAACAAAACCTTCATTGAGTTTTCATCATAACCAGATTATTTAATTGACG
AGTTGTCAACTACGAAGTTGTGGGGAATAAAATACTCTACAAGAGGAATC
ATTCAAAAATTTTATATAATACTTTTATATTCAATAAAAACAATCATTTA
AAAACAATAAAAACAATATTTAAGAAAATTATATAGACAGATAATTTAAA
AGAAATGAAATTTTTTGAAAAATATTTTAATGGAACATATTGGAATTCTT
TAGGTTTATGAATCCATCTCAGGCACTTGATCTGAGTACTCCTGCTCCAC
CACTTCGGACAACTAGTGTTATACATCAGAATAGTGAAAATTTTAATATT
TCTAAACCTCTTCCATTAATCCCATCAAATGAAGACAAGAAAAAAGACAA
AAAGTCTAAATTTAAAGGAAAGTCCATAAAAATATCGTCGGCGATTTCAC
CTTGTATACCGAACATTTCCGCACCGATTAGTGTGATGCATAAAGTCCAT
ATTACATTCAGTCAAGATACGGGAGAATTCGCAGGCGTTCCTCTCGAATG
GCAGGTTATTCTTGAGAATAATATTAGTAAAATCGAACAGCAGCAAAATC
CAAGAGCTGTTTTAAATGCATTAAACATTTTAGTGGATAAAAATAAAAAC
AAAGAGAAATATATGATGGATTTATCACTGCCGACAAATAGATCTACTGG
ATCAACGGATCGCACTCCATCAACGTCTGCAAGCATTACCGGAGACGATG
GAAATTCCAGTCCGAGTCAGGACATTCCATCTGTACCAACATTTAGTAAT
GGGAATGGATTCAATTTTAATATAAACAATGCAATATCCACCAAGGAATA
CAGTTGCACTTTAGAAATTCAGGAAACCAATTTATTGAACACAGAAGATT
TCAATGATGATAAAACTCTTTTAAGCGCAGGGAAAAACGTTCAGAATAAT
TCTCAACTTGCTAGAAATCAGACCACAACTTCTTATAATCACCTGACACC
AACTCATACCATAAAAAATAAATTGTCCGTGAAAAGTTCAGATATAATCC
ACAACTCGGCCGATAACAATTGCATCAAGGATCCTCCACCTATTGCTGAT
CGACCAGAAAAGACTAAATCTATATACACAAAACCAATTGAGGATAAATC
AGTTGCGGTTCATTCACCTAGCGCAATTAATAAAAATAGTAATTCATCAC
AGAAGAAAAAATCCAAACTATCAGAAGAAGAAATATGTGAAAAATTAAGG
AAAATTGTCAGTTTAGGTGATCCAAATAGAAAATATAAAAAACATGAAAA
AATCGGCCAAGGAGCATCTGGTGTGGTTTATAACGGAATAGAAACAAGCA
CAGGAAAAAAAGTTGCAATTAAGCAAATGCAATTGAAACAACAACCGAAG
AAAGAGTTAATAATCAACGAAATTTGTGTTATGAAAGCTAATCGACATCC
AAATGTCGTCAACTATTTAGACAGTTATCTAGTCGGTGGTACGGGGACTG
TTGCAGATGAGTTGTGGGTGGTGATGGAGTATTTGGACGGCGGCTCGTTG
ACTGAGGTTGTCACTGAGACATTTATGGACGAGGGCCACATTGCAGCGGT
CTGTAGAGAGTGCTTGCAAGCACTGGATTTCTTGCACACTAACAATGTTA
TCCATCGTGACATCAAATCAGACAATATTCTCTTGGGATTGGATGGCTCT
GTGAAACTGACAGATTTTGGATTTTGTGCCCAGCTGAATAACGAGCAAAC
GAAACGATCAACTATGGTTGGCACTCCTTACTGGATGGCTCCTGAAGTCG
TTACCCGCAAACAATACGGTCCTAAAGTCGATGTGTGGTCTCTAGGAATT
ATGGCCCTTGAAATGATAGACGGGGAACCCCCTTATCTAAATGAAAATCC
ACTTCGTGCCCTATATTTAATTGCCACTAACGGTAAACCGGAAATCAAAG
AAAAATCACGACTCTCTGTGGTTTTTCTCGATTTTTTGGATAAATGTCTA
GAAGTACAAGTTGAGAAACGAATTTCAGCATCAGAATTATTAACACATCC
TTTTATCGTCAGAAAAGCGAAACCCTTGTCCAGTTTAACACCTCTTATTG
TTGTCGCAAAAGAACAAGCTGCTTCAAGGTCGCATTAGAGCTAAATTTGA
GTAAATCTTTTCTAGAAGTATTGAACAATGATCTCATTTACTTTTTTTTT
CTATTTATATAATTGTCATTTATAATTTTGAATTCTCTGTAAATATTTTT
ATGTTGCAATCGGATTTCTTTTCCGTCTAAGATGTGCAATCTCCACCCGT
TTTTTCTTCAATATTACCATTGTGTTTATTACTCATGATTTTCATTTTGC
AGTGGATCAAGATTTATTATTAGAAAATATATATTTTGCATTCTCTCTCA
TATTTTTCATTGAACAGTTTTAAAATTTCTTGTGATTGCACATTTTTTAT
TGATTAATTGTTATAATAATATTTTATGAAATTTATTAATTGTTATTGAT
TTTAAATAAATGCAAAAAATCGTAAAGTCTACCAATCATTTTTATGTAAT
CTAGT
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protein sequence of SMED30014999-orf-1

>SMED30014999-orf-1 ID=SMED30014999-orf-1|Name=SMED30014999-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=627bp
MNPSQALDLSTPAPPLRTTSVIHQNSENFNISKPLPLIPSNEDKKKDKKS
KFKGKSIKISSAISPCIPNISAPISVMHKVHITFSQDTGEFAGVPLEWQV
ILENNISKIEQQQNPRAVLNALNILVDKNKNKEKYMMDLSLPTNRSTGST
DRTPSTSASITGDDGNSSPSQDIPSVPTFSNGNGFNFNINNAISTKEYSC
TLEIQETNLLNTEDFNDDKTLLSAGKNVQNNSQLARNQTTTSYNHLTPTH
TIKNKLSVKSSDIIHNSADNNCIKDPPPIADRPEKTKSIYTKPIEDKSVA
VHSPSAINKNSNSSQKKKSKLSEEEICEKLRKIVSLGDPNRKYKKHEKIG
QGASGVVYNGIETSTGKKVAIKQMQLKQQPKKELIINEICVMKANRHPNV
VNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCR
ECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKR
STMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLR
ALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI
VRKAKPLSSLTPLIVVAKEQAASRSH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036936CRIB_dom_sf
IPR000719Prot_kinase_dom
IPR000095CRIB_dom
IPR017441Protein_kinase_ATP_BS
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 343..600
e-value: 2.1E-96
score: 336.3
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 343..600
e-value: 2.0E-71
score: 240.5
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 343..600
score: 50.774
IPR000095CRIB domainSMARTSM00285PBD_5coord: 70..105
e-value: 1.2E-5
score: 34.8
IPR000095CRIB domainPFAMPF00786PBDcoord: 70..122
e-value: 1.5E-11
score: 44.5
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 288..425
e-value: 9.3E-43
score: 148.2
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 426..625
e-value: 2.0E-73
score: 247.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 297..322
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 139..179
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 140..179
NoneNo IPR availablePANTHERPTHR45832FAMILY NOT NAMEDcoord: 45..620
NoneNo IPR availablePANTHERPTHR45832:SF7coord: 45..620
IPR036936CRIB domain superfamilyGENE3DG3DSA:3.90.810.10coord: 67..140
e-value: 8.6E-20
score: 72.7
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 349..372
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 464..476
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 335..603