Serine/threonine-protein phosphatase with EF-hands

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELD-------------------------------QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKE--FQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +++ + IQ WYRGY+ARL+AR+  +  I+QSIEY+ EQ Q++L  FF  ++      +     L  ++L     ++   +Y + I +   Y+GP +QFPLT T I  L+ AF  +QILH HY+ E+L +T+ +LK  PN +    S  K +TICGDLHG+L DL  IF +N  P   NPYVFNGDF+DRGK+S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  + + WLP+ TI+ N+I + HGGIS    L  L  ++R+K  S L  P+++  D                               + EW Q++DILWSDP+ + GC  N  RGGGCYFGPD+T + L KY+ ++LIRSHECKP GYE CH  +V+TIFSASNYY+ GSN+GA++KL     P+   +   K   FQ    + + +  +E SA++ LR ++++ +S L   F   D   SG +    W   M  +L L+LPWR+L + L  +  +G + Y S+F+ + R++      +   V + +Y+YR  LE +F  +D+D+SG IS++EF+   K+  SH   ++    +  LA  +D+NKDGSID NEFL+AF +
Sbjct:   17 LRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQP---LRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNI-RIEKPVQEAHSTLV-ETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV 637          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQK-GCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKE--FQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +++ + IQ WYRGY+ARL+AR+  +  I+QSIEY+ EQ Q++L  FF  ++      +     L  ++L     ++   +Y + I +   Y+GP +QFPLT T I  L+ AF  +QILH HY+ E+L +T+ +LK  PN +    S  K +TICGDLHG+L DL  IF +N  P   NPYVFNGDF+DRGK+S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  + + WLP+ TI+ N+I + HGGIS    L  L  ++R+K  S L  P+++  D            +D K  K G   N    G        T    E                 +EW   ++V+TIFSASNYY+ GSN+GA++KL     P+   +   K   FQ    + + +  +E SA++ LR ++++ +S L   F   D   SG +    W   M  +L L+LPWR+L + L  +  +G + Y S+F+ + R++      +   V + +Y+YR  LE +F  +D+D+SG IS++EF+   K+  SH   ++    +  LA  +D+NKDGSID NEFL+AF +
Sbjct:   17 LRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHD----------TDSKHNKVGVTFNAH--GRIKTNGSPTEHLTE-----------------HEW---EQVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQP---LRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNI-RIEKPVQEAHSTLV-ETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV 575          

Query: 1119 QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            Q EW QV+DILWSDP  Q+GC+ N  RGGGCYFGPD+T Q L+KY  + LIRSHECKP GYE+CH  +VLTIFSASNYY+ GSN+GA+VKL  +L P I+ + A K     + + + I  +EESALR LR K+  + S L+SEF   D D  GLI    W   + +VL L LPWR LR QL   +    + Y S  + L++    + ++   S+ + +Y+ R  LET+FRI+DSD+SG IS+DEF++  K+  SH   ++T + + DLARSID NKDG ID+NEFLEAFR+ E
Sbjct:  435 QEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANK-VTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESVLHLGLPWRMLRPQLVNSSADNMLEYKSWLKNLAKEQLSRENIQS-SLLETLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEAFRLVE 725          

Query:  216 KSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALN-----KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNC 1097
            K+   IQ+WYR Y ARLE RR+C+W I+QSIEY+G+QDQ+KLH+FF  LM+     + +     T+        + + +K+ S+YE+ I +   Y+GP + FPL     T+L+ AF  +Q LH  Y+  LL +T+  L   PNI+       + IT+CGDLHGQL DLI+IF +N  P P   YVFNGDF+DRGK SVEI +ILF+F+++YP    LNRGNHED ++NLRYGF KEV  KYK H   I+    D+F WLPLAT+I  K+ I HGG+S+   LE L  I+RSK +S + C
Sbjct:   21 KAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVKLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYES-IEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRC 318          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALN-----KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNC 1097
             K+   IQ+WYR Y ARLE RR+C+W I+QSIEY+G+QDQ+KLH+FF  LM+     + +     T+        + + +K+ S+YE+ I +   Y+GP + FPL     T+L+ AF  +Q LH  Y+  LL +T+  L   PNI+       + IT+CGDLHGQL DLI+IF +N  P P   YVFNGDF+DRGK SVEI +ILF+F+++YP    LNRGNHED ++NLRYGF KEV  KYK H   I+    D+F WLPLAT+I  K+ I HGG+S+   LE L  I+RSK +S + C
Sbjct:   20 FKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQVKLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYES-IEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRC 318          

Query: 1119 QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQ 1592
            Q EW QV+DILWSDP  Q+GC+ N  RGGGCYFGPD+T Q L+KY  + LIRSHECKP GYE+CH  +VLTIFSASNYY+ GSN+GA+VKL  +L P I+ + A K     + + + I  +EESALR LR K+  + S L+SEF   D D  GL   Q
Sbjct:  435 QEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANK-VTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLASSQ 591          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E +YSGP ++   +T++ +  L+  + +++ LH    +++LVQ + +L     + ET L   + IT+CGD HGQ  DL+ IFE N  P  +NPY+FNGDF+DRG  SVE+ + LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F WLPLA  I+ K+ I HGG+   + + L+ ++ I+R++       P DS         + D+LWSDP+PQ G R    RG  C FGPD+T  FLE+     +IRSHE K  GYE  H    +T+FSA NY D   NK +++ L  S L P+   F A
Sbjct:  169 MTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQ---MYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQ------PPDSG-------PMCDLLWSDPQPQNG-RSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTA 477          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQN-------------LSSDSLFTKAL---NKSTSIKRSSE--YENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP---------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVK-LTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            MGC  S  ++N               S  + +KS I IQKWYR  +ARLEARR+ +W I+ ++EY+GEQDQLKL++FF D++  M ++N             +S+ S + K     ++  ++K+  E     ++ ++ +Y GP +  PL    +  +I AF   ++LH  Y+  +L + R I K  P++S    SI   +TICGDLHG+  DL  I  +N YP   NPY+FNGDF+DRG  S+E+  +LF+ +I+ P  ++LNRGNHED IMNLRYGFIKE+ TKYK  +  I  L  D+F WLP+ATII   IF+ HGGIS++ ++  L  I R ++ S L  P          +S ++  EW Q+LDI+WSDPK  KGC  N+FRGGG YFG DIT  FLEK+ FRLL+RSHECK  GYE+ H +  LT+FSASNYY+TGSN+GA+VK + KS +P  + + A K  +K  L  E +  +EESA++EL+ K+ +  + L  EF   D + SG +    W + +  +  L+LPW  L  ++A ++  G          ++++     H  +  + + +Y+++ TLET+FR +D DNSG++S+ EF + C++L  ++K  +  + +  +A SID NKDG IDLNE LEAFR+
Sbjct:    1 MGCGPSSGRQN--------------PSTELTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYMASKTHRKSTL-RERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPKVATLSEDGKYVMYKEDRRIAQVGG--THAQEKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRL 635          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQN-------------LSSDSLFTKAL---NKSTSIKRSSE--YENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP---------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVK-LTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            + +KS I IQKWYR  +ARLEARR+ +W I+ ++EY+GEQDQLKL++FF D++  M ++N             +S+ S + K     ++  ++K+  E     ++ ++ +Y GP +  PL    +  +I AF   ++LH  Y+  +L + R I K  P++S    SI   +TICGDLHG+  DL  I  +N YP   NPY+FNGDF+DRG  S+E+  +LF+ +I+ P  ++LNRGNHED IMNLRYGFIKE+ TKYK  +  I  L  D+F WLP+ATII   IF+ HGGIS++ ++  L  I R ++ S L  P          +S ++  EW Q+LDI+WSDPK  KGC  N+FRGGG YFG DIT  FLEK+ FRLL+RSHECK  GYE+ H +  LT+FSASNYY+TGSN+GA+VK + KS +P  + + A K  +K  L  E +  +EESA++EL+ K+ +  + L  EF   D + SG +    W + +  +  L+LPW  L  ++A ++  G          ++++     H  +  + + +Y+++ TLET+FR +D DNSG++S+ EF + C++L  ++K  +  + +  +A SID NKDG IDLNE LEAFR+
Sbjct:   81 LTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYMASKTHRKSTL-RERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPKVATLSEDGKYVMYKEDRRIAQVGG--THAQEKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRL 700          

Query:  459 NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP---------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVK-LTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
             ++ ++ +Y GP +  PL    +  +I AF   ++LH  Y+  +L + R I K  P++S    SI   +TICGDLHG+  DL  I  +N YP   NPY+FNGDF+DRG  S+E+  +LF+ +I+ P  ++LNRGNHED IMNLRYGFIKE+ TKYK  +  I  L  D+F WLP+ATII   IF+ HGGIS++ ++  L  I R ++ S L  P          +S ++  EW Q+LDI+WSDPK  KGC  N+FRGGG YFG DIT  FLEK+ FRLL+RSHECK  GYE+ H +  LT+FSASNYY+TGSN+GA+VK + KS +P  + + A K  +K  L  E +  +EESA++EL+ K+ +  + L  EF   D + SG +    W + +  +  L+LPW  L  ++A ++  G          ++++     H  +  + + +Y+++ TLET+FR +D DNSG++S+ EF + C++L  ++K  +  + +  +A SID NKDG IDLNE LEAFR+
Sbjct:   48 TNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYMASKTHRKSTL-RERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPKVATLSEDGKYVMYKEDRRIAQVGG--THAQEKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRL 565          

Query:  459 NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLT-KSLEPKIISFNA 1430
            N + +E  Y GP ++  +T   +  LI  F N+Q LH  Y F++L++    +K+ P + E  +   K  TICGD+HGQ  DL  IFE N YP  +NPY+FNGDF+DRG  SVE    +  F +LYP   F++RGNHE  +MN  YGF  EV+ KY      + ++F + F WLPL  +I+ KIF+CHGG+   + + LE ++  DR++       P D  +       + D+LWSDP+P  G R    RG GC FGPD+T ++ E      ++RSHE KP GYE  H  +  T+FSA NY D  +NKGAF+ +T  +L P+   F+A
Sbjct:  168 NAMAIEDSYDGPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKY---TQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGVTLEDIRKTDRNRQ------PPDEGI-------MCDLLWSDPQPING-RSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTPFDA 477          

Query:  519 TVITSLINAFNNEQ----ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGIS----NRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLE 1406
            ++I  +++A  +E+    ++    + +LL    G+ K +  + E +  I     +CGD+HGQ  DL+ +F    +P P+  Y+F GD++DRG+ S+E  V+L ++ + +P   FL RGNHE + +N  YGF +E Q +Y+  +  +   F D+F WLPL  +I+ KI   HGG+S        L+TL+ I+R         P++ +    E L V D+LW+DP        N  RG GC FG D       +++  L+ R+H+    GYE+    +++TIFSA +Y     N  AF+   + L+
Sbjct:    8 SIIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPI----KVCGDIHGQFPDLLRLFHRGGWP-PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQ--SVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLDTLRKIER---------PTEGK----EGL-VADLLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQ 290          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:    6 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 599          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:   22 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 615          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:   91 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 684          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:   91 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 684          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:   91 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 684          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKS----TSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDS 1109
            + +K+ I IQ+WYR Y A LE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q N +   L +  L+      T   R  +YE  I +   YSGP + FPL++T   +L++AF  EQ LHG Y+ +LL +T+  LK  PN+     S  K ITICGDLHG+L DL+ IF +N  P   NPY+FNGDF+DRGK S EI +ILF+F++LYP  + LNRGNHED IMNLRYGF +EV  KYK H   I+ L  D+F  LP+AT+I NK+ I HGGIS++  L+ L  ++R K  SAL  P  S
Sbjct:   29 LTIKAAILIQRWYRRYVAHLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFTFMLDNFTQINGNGPDLISHLLDSVVDPLTEEVRQLKYEQ-IMVPESYSGPRLSFPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKKFLKQMPNVIYLSTSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSTEIIIILFAFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKYKTHGREILQLLQDVFSLLPVATVIDNKVLIVHGGISDKTDLDFLSTVERHKVKSALRLPKRS 332          

Query: 1098 PSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            P +   ++ EW QV+DILWSDPK Q GC  N FRGGGCYFGPD+T   L+K+   LLIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA+VKL   L P+   +   +  +K + +++ +   E SALR L+ K+  +RS+LM+ F   D +N+G I    W  ++ +VL+LDLPWRTLR +LA +   G + Y S FE +S  +        +  ++ +Y+YR  LE +F I+D D+SG+ISI+EF++  K+  SH    +  + ++D+ARSID NKDGSID  EFLEAFR+
Sbjct:  423 PPELPREELEWQQVVDILWSDPKHQNGCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTRK-LTLHQRVRVAEGSALRALKEKLYAHRSELMAAFQQYDINNTGRISTSEWAQVVESVLRLDLPWRTLRPRLARLGTDGNVEYESCFEDISPGEPIPPVTPNL--AETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSSHLGVAVNDQTIDDMARSIDFNKDGSIDFTEFLEAFRV 717          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKS----TSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDS 1109
            +K+ I IQ+WYR Y A LE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q N +   L +  L+      T   R  +YE  I +   YSGP + FPL++T   +L++AF  EQ LHG Y+ +LL +T+  LK  PN+     S  K ITICGDLHG+L DL+ IF +N  P   NPY+FNGDF+DRGK S EI +ILF+F++LYP  + LNRGNHED IMNLRYGF +EV  KYK H   I+ L  D+F  LP+AT+I NK+ I HGGIS++  L+ L  ++R K  SAL  P  S
Sbjct:   20 IKAAILIQRWYRRYVAHLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFTFMLDNFTQINGNGPDLISHLLDSVVDPLTEEVRQLKYEQ-IMVPESYSGPRLSFPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKKFLKQMPNVIYLSTSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSTEIIIILFAFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKYKTHGREILQLLQDVFSLLPVATVIDNKVLIVHGGISDKTDLDFLSTVERHKVKSALRLPKRS 321          

Query: 1098 PSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            P +   ++ EW QV+DILWSDPK Q GC  N FRGGGCYFGPD+T   L+K+   LLIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA+VKL   L P+   +   +  +K + +++ +   E SALR L+ K+  +RS+LM+ F   D +N+G I    W  ++ +VL+LDLPWRTLR +LA +   G + Y S FE +S  +         ++++ +Y+YR  LE +F I+D D+SG+ISI+EF++  K+  SH    +  + ++D+ARSID NKDGSID  EFLEAFR+
Sbjct:  412 PPELPREELEWQQVVDILWSDPKHQNGCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTRK-LTLHQRVRVAEGSALRALKEKLYAHRSELMAAFQQYDINNTGRISTSEWAQVVESVLRLDLPWRTLRPRLARLGTDGNVEYESCFEDISPGEPIPPVTP--NLAETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSSHLGVAVNDQTIDDMARSIDFNKDGSIDFTEFLEAFRV 706          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKS----TSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDS 1109
            +K+ I IQ+WYR Y A LE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q N +   L +  L+      T   R  +YE  I +   YSGP + FPL++T   +L++AF  EQ LHG Y+ +LL +T+  LK  PN+     S  K ITICGDLHG+L DL+ IF +N  P   NPY+FNGDF+DRGK S EI +ILF+F++LYP  + LNRGNHED IMNLRYGF +EV  KYK H   I+ L  D+F  LP+AT+I NK+ I HGGIS++  L+ L  ++R K  SAL  P  S
Sbjct:   20 IKAAILIQRWYRRYVAHLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFTFMLDNFTQINGNGPDLISHLLDSVVDPLTEEVRQLKYEQ-IMVPESYSGPRLSFPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKKFLKQMPNVIYLSTSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSTEIIIILFAFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKYKTHGREILQLLQDVFSLLPVATVIDNKVLIVHGGISDKTDLDFLSTVERHKVKSALRLPKRS 321          

Query: 1098 PSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            P +   ++ EW QV+DILWSDPK Q GC  N FRGGGCYFGPD+T   L+K+   LLIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA+VKL   L P+   +   +  +K + +++ +   E SALR L+ K+  +RS+LM+ F   D +N+G I    W  ++ +VL+LDLPWRTLR +LA +   G + Y S FE +S  +         ++++ +Y+YR  LE +F I+D D+SG+ISI+EF++  K+  SH    +  + ++D+ARSID NKDGSID  EFLEAFR+
Sbjct:  412 PPELPREELEWQQVVDILWSDPKHQNGCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTRK-LTLHQRVRVAEGSALRALKEKLYAHRSELMAAFQQYDINNTGRISTSEWAQVVESVLRLDLPWRTLRPRLARLGTDGNVEYESCFEDISPGEPIPPVTP--NLAETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSSHLGVAVNDQTIDDMARSIDFNKDGSIDFTEFLEAFRV 706          

Query: 1125 EWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            EW Q+LD+LWSDP  Q GC  N  RGGGCY+GP+IT  FL ++  +L+IRSHECK  GYE+CH  +V+T+FSASNYY+ GSN+GAFV+L   L P  I + A     + +   + +   E +AL+ LR K+  ++S L+S F   D +N+GLI    W   +  VL LDLPWR L  QL   T +G +NY   F  L+ +    + + + S+ + +Y++R TLET+FRI+D+DNSG IS ++F++  K+L ++ K  ++ E + +L  S+D N DGSID++EF+EAFR+
Sbjct:  387 EWKQILDLLWSDPMSQDGCVPNEVRGGGCYWGPNITEDFLNRHNLQLIIRSHECKQDGYEFCHNRKVVTLFSASNYYEIGSNRGAFVRLGPDLMPYFIQYQATS-MTRGLSFPQNVKRTEHTALKVLREKLFAHKSDLLSAFQELDKENTGLISLSDWARAVERVLHLDLPWRILHPQLVSSTTNGMLNYHGWFCDLA-LKKPNSEVIEQSMLETLYRHRSTLETIFRIVDTDNSGLISFEDFRQTLKLLSAYLKMEISDEVINELVVSMDTNNDGSIDIDEFMEAFRL 673          

Query:  264 LEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYE-----NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            +E RR+ +W I+QS+EY+  QDQ+KL+NF   L++       SS+      + +   + R +E+E      +I +   YSGP + FPL +     L+ AF N+Q LH  Y+ +LL++T  +L+  PNI+       K ITICGDLHGQL+DL+ IF +N  P    PYVFNGD++DRGK S+E+ +ILF+FL++YPG V+LNRGNHED I+NLRYGF KEV  KYK H   I+ L   IF WLPL T+I  ++ I HGGIS+   L  +  +DR +Y+SAL  P
Sbjct:    1 MEMRRRYTWNIFQSMEYADLQDQIKLYNFLGYLVDNFTPS--SSERNLISHIFRENEVCRDAEWERYFNYTNIDVPDIYSGPRLTFPLDMDQAADLVEAFKNKQQLHSRYVLQLLLETWKLLRVLPNINRVSTCHSKEITICGDLHGQLEDLLLIFYKNGMPSMEKPYVFNGDYVDRGKDSMEVLLILFAFLLVYPGDVYLNRGNHEDHIINLRYGFTKEVLGKYKLHGKRILKLLQKIFSWLPLVTVIDQRVLIVHGGISDSTNLALIARVDRHRYVSALRPP 282          

Query:  432 SIKRSSEYENDIPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            S+  S + EN + +E DY+GP ++   +TL  +  L++ F +++ LH    +++LVQ + +L   P++ E  L   + ITICGD HGQ  DL+ IFE N  P P+NPY+FNGDF+DRG  SVE+ + LF F +LYP    L RGNHE   MN  YGF  EV+ KY   ++ +  LF+++F+WLPLA  I++K+ + HGG+   + + L+ ++ IDR++       P DS         + D+LWSDP+ Q G R    RG  C FGPD+T +FLE+ K   ++RSHE K  GYE  H  + +T+FSA NY D   NKGA++ L  S L+P+   F A
Sbjct:  150 SVVDSLDIEN-MTIEDDYAGPKLEDGKVTLKFMEDLMDWFKDQKKLHRKCAYQILVQVKEVLTKLPSLVEITLKESEKITICGDTHGQYYDLLNIFELNSLPSPTNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPEHFHLLRGNHETDNMNQMYGFEGEVKAKY---SSQMFKLFSEVFQWLPLAQCINDKVLVMHGGLFSEDGVTLDDIRKIDRNRQ------PPDSG-------PMCDLLWSDPQLQNG-RSISKRGVSCQFGPDVTERFLEQNKLEYIVRSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTA 468          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNL-RYGFIKEVQTKYKAHANSI-----INLFADIFRWLPLATIISNKI-------------------FICHGGISNRI--QLETLKNIDRSKYISALNCPSDSELD-------------------QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLS-RMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            + +K+ I IQ+WYR Y ARLE RR+ +  I+QSIEY+ EQ QL+L NFF  +M+           L +   N S    +  +YE  I +   Y GP I FPLT++   +L+ AF   Q LH  Y+ +L  +T+  LK  PNI     S  K ITICGDLHG+L DL+ IF +N  P   N Y+FNGD +DRGK+S+EI V+LF+FL++YP  V +NRGNHED IMNL R      V +K       I     ++  + I R+   + + + K                     +  G   NR    + T  NI +++       P   E++                   + EW QV+DILWSDP+ Q GC  N FRGGGCYFGP++T + L KY F++LIRSHECK  GYE CH  +V+TIFSASNYYD GSN+GA++KL+  L P+ + +   K  +K + +++ + A+E++ALR LR KI  +RS+L++ F  CD   +G I    W + + AVL LDLPWRTLR +L  +T  G+++Y S+FE L      K+   N +   + IY+Y+  LE +F I+D D+SG IS++EF++  K+  SH   N+   A++DLA SID NKDGSID NEFLEAFR+
Sbjct:   17 LAIKAAILIQRWYRFYTARLEMRRRYTLNIFQSIEYAEEQAQLQLSNFFTFMMDHFAHWKGQGPDLISDISN-SKEGHKFIDYEK-IEVPNSYGGPRITFPLTVSDTNALLRAFKQGQQLHARYVLQLFHETKKFLKQLPNIVHLSTSYSKEITICGDLHGKLDDLLLIFYKNGLPSTENHYLFNGDLVDRGKNSIEILVLLFTFLLMYPNNVHINRGNHEDPIMNLSRLPLATIVDSKVLILHGGIGDKTDLDFLSSIDRFKYKSALRTPKTDSEKCTSRDKMLDGKNKKSSVDVGANQNRANKHMTTSSNISQNRSQQGFRSPGILEINYMDSRIQLPDKMPELPDSIRKEWKQVVDILWSDPRNQNGCTPNSFRGGGCYFGPNVTKKLLAKYNFKMLIRSHECKQEGYELCHNGKVVTIFSASNYYDEGSNRGAYLKLSPDLTPRFVPYQVSKCTRK-LTLHQRVSAVEDTALRALREKIYAHRSELINAFKLCDPKETGKISISEWASAVEAVLHLDLPWRTLRPRLIKLTSDGSVDYLSSFEDLQIEQPIKEVQPNLV---ETIYRYKADLEIIFNIIDKDHSGLISVEEFRQTWKLFSSHLHINIDDSAIDDLAHSIDTNKDGSIDFNEFLEAFRV 652          

Query: 1104 DSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            + ++D  E  Q++DILWSDP PQ GC+ N  RGGGCYFGPD+T + L+K+  ++LIRSHECK  GYE+CH  +VLTIFSASNYY+ GSNKGAFVKL   L P  + + A +    ++ + + +  +EESALR LR K+  ++S LM+ F   D + +G I    W  ++ +VL L LPWR LR QL   +P G + Y   F+ LS     Q H++  S+ + +Y+ R  LET+FRI+DSD+SG IS +EF+   K+L SH    ++ EA+  +ARSID NKDG+ID+NEFLEAFR+
Sbjct:  400 ECDIDDEEKKQIVDILWSDPIPQDGCKSNTVRGGGCYFGPDVTEKILQKHGLQMLIRSHECKQEGYEFCHSGKVLTIFSASNYYEVGSNKGAFVKLGPDLVPHFVQYQASR-LTNNLTLRQRVSTVEESALRALREKLFAHKSDLMNAFRNYDNNQTGYINLSDWAIVLESVLNLGLPWRMLRPQLIHSSPEGLLRYREWFDELSVCQPIQEHLHD-SLLEALYRNRSDLETIFRIIDSDSSGLISFEEFQHTWKLLSSHLNIEVSDEAICKMARSIDFNKDGNIDINEFLEAFRL 693          

Query:  261 RLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDS----LFTKALN-KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISAL 1091
            ++E RR+C+W I+QSIEY+GEQDQ+KL++FF  LM+     N         +FT+  N K T +++  +YE  I +   Y+GP + FP+  T  T+L+ AF   Q LH  Y+  LL +T+  LK  PNI     S  K ITICGDLHG+L DL  IF +N  P P  PY+FNGDF+DRGK S+EI +ILF+F ++YP  V LNRGNHED I+NLRYGF KEV  KYK H   I+ +   +F WLPLAT+I  K+ + HGG+S+   LE L  I+R K+ S L
Sbjct:    1 QMEVRRRCTWSIFQSIEYTGEQDQIKLYDFFNLLMDHFTPDNSKERDFICRIFTEEENFKDTELEKYCDYET-IEVPESYTGPHLSFPIKPTHATALVEAFKQNQQLHSRYVLHLLHETKKYLKQLPNIKRISTSYGKEITICGDLHGRLDDLFLIFYKNGLPSPEKPYIFNGDFVDRGKQSIEILMILFAFQLVYPKVVHLNRGNHEDYIVNLRYGFTKEVMKKYKVHGKKILKMLQSVFSWLPLATLIDQKVLVTHGGVSDTTDLEILSKIERHKFASTL 281          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E +Y+GP ++   +T+  +  L+  + +++ LH   ++++LVQ + IL   P++ E  L   + +T+CGD HGQ  DL+ IF  N  P  +NPY+FNGDF+DRG  SVE+ V LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F+WLPLA  ++ ++ I HGG+   + + L+ +++I+R++       P DS         + D+LWSDP+PQ G R +  RG  C FGPD+T +FLE+     +IRSHE KP GYE  H    +T+FSA NY D   NKGA++ L  S L+PK   F A
Sbjct:  182 MTIEDEYTGPQLKDGNVTIDFMLELMQFYKDQKKLHRKCVYQMLVQVKDILSKLPSLVEISLEKSQQVTVCGDTHGQFYDLMNIFHLNGLPSENNPYIFNGDFVDRGSFSVEVIVTLFGFKLLYPAHFHLLRGNHETDTMNQMYGFEGEVKAKYSAQ---MFQLFSEVFQWLPLAMCVNQRVLIMHGGLFSEDGVTLDQIRSIERNRQ------PPDSG-------PMCDLLWSDPQPQDG-RSSSKRGVSCQFGPDVTRRFLEENGLDYIIRSHEVKPEGYEVSHNGLCVTVFSAPNYCDQMGNKGAYIHLNGSDLKPKFHQFEA 490          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E +Y+GP ++   +T+  +  L+  + +++ LH   ++++LVQ + IL   P++ E  L   + +T+CGD HGQ  DL+ IF  N  P  +NPY+FNGDF+DRG  SVE+ V LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F+WLPLA  ++ ++ I HGG+   + + L+ +++I+R++       P DS +     L +   ++SD       R +  RG  C FGPD+T +FLE+     +IRSHE KP GYE  H    +T+FSA NY D   NKGA++ L  S L+PK   F A
Sbjct:  182 MTIEDEYTGPQLKDGNVTIDFMLELMQFYKDQKKLHRKCVYQMLVQVKDILSKLPSLVEISLEKSQQVTVCGDTHGQFYDLMNIFHLNGLPSENNPYIFNGDFVDRGSFSVEVIVTLFGFKLLYPAHFHLLRGNHETDTMNQMYGFEGEVKAKYSAQ---MFQLFSEVFQWLPLAMCVNQRVLIMHGGLFSEDGVTLDQIRSIERNRQ------PPDSGVTLVLLLLLSFPIFSD------GRSSSKRGVSCQFGPDVTRRFLEENGLDYIIRSHEVKPEGYEVSHNGLCVTVFSAPNYCDQMGNKGAYIHLNGSDLKPKFHQFEA 492          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E +Y+GP ++   +T+  +  L+  + +++ LH     + + Q R  L                + +CGD HGQ  DL+ IF  N  P  +NPY+FNGDF+DRG  SVE+ V LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F+WLPLA  ++ ++ I HGG+   + + L+ +++I+R++       P DS         + D+LWSDP+PQ G R +  RG  C FGPD+T +FLE+     +IRSHE KP GYE  H    +T+FSA NY D   NKGA++ L  S L+PK   F A
Sbjct:  165 MTIEDEYTGPQLKDGNVTIDFMLELMQFYKDQKKLHR----KCVYQVRFCLS---------------LYMCGDTHGQFYDLMNIFHLNGLPSENNPYIFNGDFVDRGSFSVEVIVTLFGFKLLYPAHFHLLRGNHETDTMNQMYGFEGEVKAKYSAQ---MFQLFSEVFQWLPLAMCVNQRVLIMHGGLFSEDGVTLDQIRSIERNRQ------PPDSG-------PMCDLLWSDPQPQDG-RSSSKRGVSCQFGPDVTRRFLEENGLDYIIRSHEVKPEGYEVSHNGLCVTVFSAPNYCDQMGNKGAYIHLNGSDLKPKFHQFEA 454          

Query:  210 MMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALN---KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-----------------------------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            ++K+ + IQ WYR Y+ARL  R+  +  I+QSIEYS EQ Q++L +FF  ++    + N    +L T+  +   + + IK   ++   I +   Y GP +QFPLT T I  L+ AF  +QILH HY+ E+L + R +LK  PN S       K ITICGDLHG+L DL+ IF +N  P  +NPYVFNGDF+DRG +S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  +++ WLP+ TII N+I + HGGIS    L TL  + R+K  S L  P                                +L + EW Q++DILWSDP+ +KGC  N  RGGGCYFGPD+T + L K + ++LIRSHECKP GYE  H  +V+T+FSASNYY+ GSN+GA+++L+    P+   +        + L ++ ++A+E SA + L+ K+++ ++ L++ F   D   SG I    W   M  +L L+LPWR+L + L  +  SG+++Y S+F+ + R++     M K ++++ +Y+YR  L+ +F I+DSD SG IS+DEF+   K+  +H KA++    +++LA  +D NKDG+ID NEFL+AF +
Sbjct:   16 VIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVEPDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPL-HQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPWRSLSSHLVTIDSSGSVDYMSSFDDI-RIEKPTKDM-KSNLTETMYRYRSDLKIIFNIIDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYV 638          

Query: 1125 EWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDN 2003
            EW QV+DILWSDP  Q+GC+ N  RGGGCYFGPD+T + +EKYK +LLIRSHECKP GYE+CH  +VLTIFSASNYY+ GSN+GA+VKL  +L P I+ + A K   + + + + I  +EESALR LR K+  + S L+ EF   D D SG+I    W   + +VL L LPWR LR QL   +    + Y S  + L++    + ++   S+ +++Y+ R  LET+FRI+DSD+SG IS+DEF++  K+  SH   ++T + + DLARSID NKDG ID+NEFLEAFR+ E +
Sbjct:  441 EWKQVVDILWSDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHR-LTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSADNVLEYRSWLDSLAKEQLSRENIQS-SLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQS 731          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSS----DSLFTKA-LNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAE 1127
             K+   IQ+WYR Y ARLE RR+C+W I+QSIEY+G+QDQ+KLH FF  L++     +       + +FT+    +    +   ++E+ I +   Y+GP + FPL     T+L+ AF   Q LH  Y+  LL +TR  L   PNI+       + +T+CGDLHGQL DLI+IF +N  P P   YVFNGDF+DRGK SVE+ ++LF+F+++YP    LNRGNHED ++NLRYGF KEV  KYK H   I+    D+F WLPLAT++  K+ + HGG+S++  LE L  +DR K +S + C +  E +  E
Sbjct:   20 FKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEGGDFES-IEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENRE 328          

Query: 1125 EWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDN 2003
            EW QV+DILWSDP  Q+GC+ N  RGGGCYFGPD+T + +EKYK +LLIRSHECKP GYE+CH  +VLTIFSASNYY+ GSN+GA+VKL  +L P I+ + A K   + + + + I  +EESALR LR K+  + S L+ EF   D D SG+I    W   + +VL L LPWR LR QL   +    + Y S  + L++    + ++   S+ +++Y+ R  LET+FRI+DSD+SG IS+DEF++  K+  SH   ++T + + DLARSID NKDG ID+NEFLEAFR+ E +
Sbjct:  441 EWKQVVDILWSDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHR-LTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSADNVLEYRSWLDSLAKEQLSRENIQS-SLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQS 731          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSS----DSLFTKA-LNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAE 1127
             K+   IQ+WYR Y ARLE RR+C+W I+QSIEY+G+QDQ+KLH FF  L++     +       + +FT+    +    +   ++E+ I +   Y+GP + FPL     T+L+ AF   Q LH  Y+  LL +TR  L   PNI+       + +T+CGDLHGQL DLI+IF +N  P P   YVFNGDF+DRGK SVE+ ++LF+F+++YP    LNRGNHED ++NLRYGF KEV  KYK H   I+    D+F WLPLAT++  K+ + HGG+S++  LE L  +DR K +S + C +  E +  E
Sbjct:   20 FKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEGGDFES-IEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENRE 328          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E +YSGP ++   +T+T +  L+  + +++ LH    +++LVQ + +L     + ET L   + IT+CGD HGQ  DL+ IFE N  P  +NPY+FNGDF+DRG  SVE+ + LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F WLPLA  I+ K+ I HGG+   + + L+ ++ I+R++       P DS         + D+LWSDP+PQ G R    RG  C FGPD+T  FLE+ +   +IRSHE K  GYE  H    +T+FSA NY D   NK +++ L  S L P+   F A
Sbjct:  170 MTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQ---MYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQ------PPDSG-------PMCDLLWSDPQPQNG-RSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTA 478          

Query:  423 KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETL 1055
            + + IK   ++   I +   Y GP +QFPLT T I  L+ AF  +QILH HY+ E+L + R +LK  PN S       K ITICGDLHG+L DL+ IF +N  P  +NPYVFNGDF+DRG +S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  +++ WLP+ TII N+I + HGGIS    L TL
Sbjct:   25 RESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTL 235          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQN-------------LSSDSLFTKAL---NKSTSIKRSSE--YENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP---------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVK-LTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            + +KS I IQKWYR  +ARLEARR+ +W I+ ++EY+GEQDQLKL++FF D++  M ++N             +S+ S + K     ++  ++K+  E     ++ ++ +Y GP +  PL    +  +I AF   ++LH  Y+  +L + R I K  P++S    SI   +TICGDLHG+  DL  I  +N YP   NPY+FNGDF+DRG  S+E+  +LF+ +I+ P  ++LNRGNHED IMNLRYGFIKE+ TKYK  +  I  L  D+F WLP+ATII   IF+ HGGIS++ ++  L  I R ++ S L  P          +S ++  EW Q+LDI+WSDPK  KGC  N+FRGGG YFG DIT  FLEK+ FRLL+RSHECK  GYE+ H +  LT+FSASNYY+TGSN+GA+VK + KS +P  + + A K  +K  L  E +  +EESA++EL+ K+ +  + L  EF   D + SG +    W + +  +  L+LPW  L  ++A ++  G          ++++     H  +  + + +Y+++ TLET+FR +D DNSG++S+ EF + C++L  ++K  +  + +  +A SID NKDG IDLNE LEAFR+
Sbjct:   81 LTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPPVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYMASKTHRKSTL-RERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPKVATLSEDGKYVMYKEDRRIAQVGG--THAQEKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRL 700          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELD-------------------------------QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKE--FQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +++ + IQ WYRGY+ARL+AR+  +  I+QSIEY+ EQ Q++L  FF  ++      +     L  ++L     ++   +Y + I +   Y+GP +QFPLT T I  L+ AF  +QILH HY+ E+L +T+ +LK  PN +    S  K +TICGDLHG+L DL  IF +N  P   NPYVFNGDF+DRGK+S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  + + WLP+ TI+ N+I + HGGIS    L  L  ++R+K  S L  P+++  D                               + EW Q++DILWSDP+ + GC  N  RGGGCYFGPD+T + L KY+ ++LIRSHECKP GYE CH  +V+TIFSASNYY+ GSN+GA++KL     P+   +   K   FQ    + + +  +E SA++ LR ++++ +S L   F   D   SG +    W   M  +L L+LPWR+L + L  +  +G + Y S+F+ + R++      +   V + +Y+YR  LE +F  +D+D+SG IS++EF+   K+  SH   ++    +  LA  +D+NKDGSID NEFL+AF +
Sbjct:   17 LRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQP---LRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNI-RIEKPVQEAHSTLV-ETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYV 637          

Query:  210 MMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKAL-NKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP--------------------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            ++++ + IQ WYR Y+ARL AR+  +  I+QSIEY+ EQ Q++L +FF  ++      +    +L ++   N     K   EY   I +   Y GP +QFPLT T I  L+ AF  +Q LH HY+ E+L + R ILK  PN +       K ITICGDLHG+L DL+ IF +N  P   NPYVFNGDF+DRG +S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  +++ WLP+ TII N+I + HGGIS    L  L+ + R+K  S L  P                    +  +L + EW Q++D+LWSDP+ +KGC  N  RGGGCYFGPD+T + L K + +++IRSHECKP GYE CH  +V+T+FSASNYY+ GSN+GA+++L+    P+   +        + L  + ++A+E SA R L+ +++  ++ L++ F   D   +G I    W   M ++L L+LPWR+L + L     SG+++Y S+F+ +  ++     M K  + + +Y+YR  L+ +F I+D+D SG IS+DEF+   K+  +H K ++    +++LA ++D NKDG+ID NEFL AF +
Sbjct:   16 VVRAALIIQNWYRRYRARLSARQHYALAIFQSIEYADEQGQMQLSSFFSFMLENYTNTHKEDSALVSRLFENTRLESKDREEYVGLIDVPDSYDGPRLQFPLTFTDINLLLQAFKQQQTLHAHYVLEVLFEARKILKQMPNFTRIQTFPAKEITICGDLHGKLDDLMLIFYKNGLPSEKNPYVFNGDFVDRGNNSMEILMILLVSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGKKILQVLEELYTWLPIGTIIDNEILVIHGGISESTDLNILQQLQRNKMKSVLMPPMSTNQECNIKKNKAGPSEQSASEQLTKLEWEQIIDLLWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLNKNQLKMVIRSHECKPDGYEICHDGKVITVFSASNYYEEGSNRGAYIRLSYGTSPQFFQYQVTSTSCLNPLY-QRVNAMEFSAFRILKERMIARKTDLINAFELRDHSRTGKISLAQWAFSMESILGLNLPWRSLSSHLVSTDSSGSVDYMSSFDDI-HIEKPMKDM-KSDLIETMYRYRSDLKIIFNIIDTDQSGLISMDEFRTMWKLFNAHYKVHIDDSQIDELASTMDSNKDGNIDFNEFLRAFYV 627          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLE-TDYSGPIIQFPLTLTVITSLINAFNNEQ--ILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE-LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            +++ I IQKWYR +QAR E +R+C+W I+Q++EY+ EQDQ +L+ FF DL+  M    G++N    S     L+           ++D+  E  D     I+ P+    I  LI+ F  ++   LH  Y+  +L +    LK  PNIS    ++ + +T+CGDLHG+L DL+ +  +N  P  SNPYVFNGDF+DRGK  +E+ ++L S  + +P  VFLNRGNHED +MN RYGFI+EV++KY  +   I+    +++RWLPL +++++++ I HGG S+   L+ +K+IDR KY+S L  P +D E LD+ EW Q+ DI+WSDP+   GC  N  RG G +FGPD+T  FL++++   +IRSHECKP G+E+ H ++++TIFSASNYY  GSNKGA+++L   L P  + + +     K +   + +  +E SAL+EL  ++  +R +L  EF   D  +SG I   HWC +M  V +L LPWR LR++LA  T S  +NY+ T +LL      +   + +SV D +Y  + +L  +F I+D+DNSG I++DEF+    +L +H     +   M +  R +D+N DG +DLNEFLEAFR+++
Sbjct:    6 IRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDD----------KDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSD 599          

Query:  210 MMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALN---KSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-----------------------------SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            ++K+ + IQ WYR Y+ARL  R+  +  I+QSIEYS EQ Q++L +FF  ++    + N    +L T+  +   + + IK   ++   I +   Y GP +QFPLT T I  L+ AF  +QILH HY+ E+L + R +LK  PN S       K ITICGDLHG+L DL+ IF +N  P  +NPYVFNGDF+DRG +S+EI +IL    ++YP  + LNRGNHED +MNLRYGF KE+  KYK H   I+ +  +++ WLP+ TII N+I + HGGIS    L TL  + R+K  S L  P                                +L + EW Q++DILWSDP+ +KGC  N  RGGGCYFGPD+T + L K + ++LIRSHECKP GYE  H  +V+T+FSASNYY+ GSN+GA+++L+    P+   +        + L ++ ++A+E SA + L+ K+++ ++ L++ F   D   SG I    W   M  +L L+LPWR+L + L  +  SG+++Y S+F+ + R++     M K ++++ +Y+YR  L+ +F I+DSD SG IS+DEF+   K+  +H KA++    +++LA  +D NKDG+ID NEFL+AF +
Sbjct:   16 VIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVEPDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPL-HQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPWRSLSSHLVTIDSSGSVDYMSSFDDI-RIEKPTKDM-KSNLTETMYRYRSDLKIIFNIIDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYV 638          

Query:  177 EDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLS-------SDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKH--------------------ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP----SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLS---RMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +D E      + ++S + IQKWYR Y+ARLEARR+ SWMIYQSIEYS E  QL L+NFF D++ L G            ++ L  +++ +           ++I +E +Y GP + FPL+ T +  +I++F    +LH  YL +LL +TR +LKT+ NI     SI K                     +T+ GDLHG+L+DL+ +  +N  PD +NPY+FNGDF+DRG +SVEI  ILF+  +++P  VFLNRGNHED++MNLRYGFIKEVQ KY+  AN ++N+F+++F W+PLAT+I +++F+ HGGIS+++ L+ ++ +DR +Y+S L  P    SD ++D  EW QVLD+LWSDPK Q GC+ N FRGGGCYFGP++T  FL+KY ++LL+RSHECK  G+E+CH+D VLT+FSASNYY+ GSNKGA+VK      P+++ F A +  +  +   + + ++EESALR+LR KIL N+S+L+  FL  D + +G I    WC+ M   L+L+LPWRTLR  LA +   G + Y STF+  +   R+   +   N  SV++ +YK ++ LET+FRI+D DNSG+IS++EFKE C+IL   ++  MT + + D+A+S+D+N DG ID NEFLEAFRI
Sbjct:   49 DDMEAEAKNEVSLQSAVLIQKWYRRYKARLEARRQTSWMIYQSIEYSSESSQLHLYNFFNDMLRLGGGSVGGASANAGFAERLRQRSIEEEDEELLEHTGYSEITVERNYKGPKLSFPLSATHVQLMIDSFRQGGLLHARYLLQLLHETRSVLKTRQNIQLVSSSISKQLDSVIKKLSLNANFHAPILKVTVVGDLHGKLEDLLIVLYKNGLPDVTNPYIFNGDFVDRGPNSVEILAILFACQLVWPSAVFLNRGNHEDQVMNLRYGFIKEVQYKYRQTANKVLNMFSEVFAWMPLATVIDDRVFVTHGGISDKVDLDRVRRLDRHRYVSVLRPPVAKSSDEKVDYMEWRQVLDLLWSDPKAQPGCKPNTFRGGGCYFGPNVTRAFLDKYGYKLLVRSHECKQDGWEFCHEDTVLTVFSASNYYEEGSNKGAYVKFDSECRPRLVQFVASR--RDKLPKGQRLSSVEESALRDLRGKILANKSELIDAFLRLDPEKTGAIRVSQWCSTMEEQLRLELPWRTLRPHLAQLNKDGRLLYMSTFQRAAIQHRLSGGKEMAN--SVTETVYKNKEELETIFRIMDKDNSGQISLEEFKESCRILCQATQRQMTEDEVADMAKSLDLNSDGYIDFNEFLEAFRI 683          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLS-------SDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKH--------------------ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP----SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLS---RMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            + ++S + IQKWYR Y+ARLEARR+ SWMIYQSIEYS E  QL L+NFF D++ L G            ++ L  K++ +           +++ +E +Y GP + FPL+ T +  +I++F    +LH  YL +LL +TR +LKT+ NI     SI K                     +T+ GDLHG+L+DL+ +  +N  PD +NPY+FNGDF+DRG +SVEI  ILF+  +++P  VFLNRGNHED++MNLRYGFIKEVQ KY+  AN ++N+F+++F W+PLAT+I +++F+ HGGIS+++ L+ ++ +DR +Y+S L  P    SD ++D  EW QVLD+LWSDPK Q+GC+ N FRGGGCYFGP++T  FL+KY ++LL+RSHECK  G+E+CH+D VLT+FSASNYY+ GSNKGA+VK      P+++ F A +  +  +   + + ++EESALR+LR KIL ++S+L+  FL  D + +G I    WC+ M   L+L+LPWRTLR  LA +   G + Y STF+  +   R+   +   N  SV++ +YK R+ LET+FRI+D DNSG+IS++EFKE C+IL   ++  MT + + D+A+S+D+N DG ID NEFLEAFRI
Sbjct:   59 VSLQSAVLIQKWYRRYKARLEARRQTSWMIYQSIEYSSESSQLHLYNFFNDMLRLGGGGVGGASANAGFAERLRQKSIEEEDEELLEHTGYSEMTVERNYKGPKLSFPLSATHVQLMIDSFRQGGLLHARYLLQLLHETRSVLKTRQNIQLVSSSISKQLDLVIKMLSLNANFHAPILKVTVVGDLHGKLEDLLIVLYKNGLPDVTNPYIFNGDFVDRGPNSVEILAILFACQLVWPSAVFLNRGNHEDQVMNLRYGFIKEVQYKYRQTANKLLNMFSEVFAWMPLATVIDDRVFVTHGGISDKVDLDRVRRLDRHRYVSVLRPPVAKSSDEKVDYMEWRQVLDLLWSDPKAQQGCKPNTFRGGGCYFGPNVTRAFLDKYGYKLLVRSHECKQDGWEFCHEDTVLTVFSASNYYEEGSNKGAYVKFDSECRPRLVQFVASR--RDKLPKGQRLSSVEESALRDLRGKILASKSELIDAFLRLDPEKTGAIRVSQWCSTMEEKLRLELPWRTLRPHLAQLNKDGRLLYMSTFQRAAIQHRLSGGKEMAN--SVTETVYKNREELETIFRIMDKDNSGQISLEEFKESCRILCQATQRQMTEDEVADMAKSLDLNSDGYIDFNEFLEAFRI 683          

Query:  177 EDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----------------GQQNLSSDSLFTKALNKSTSIKRS-----SEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-SDSE---LDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLS---RMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +D  D   + + +KS + IQKWYR Y+ARLEARR+ +WMIYQSIEYS E  QL L+NFF D+M L                 G  + +++    +   KS   +       + YE  I +E  Y GP + FPL+ + +  LI++F     LH  YL +LL + R +LKTKPN+ +   SI + +T+ GDLHG+L DL+ IF +N  PD +NPYVFNGDF+DRG +SVE A +LF+ L+++P  VF+NRGNHED +MN RYGFIKEVQ KYK  AN I+ LF D F WLPLAT I +KI + HGGIS+++ +E ++ +DR +Y+SAL  P SD+E   +D  EW QVLD+LWSDPKPQ GC  N FRGGGCYFGP+IT  FL K+KF LL+RSHECKP G+E+CH   VLT+FSASNYY+ GSNKGA+ K     +P I+ + A K   + + +   +  +EE AL++LR K++ ++++L + F   D D +G I    WC  M   L+L LPWRTLR  LA +   G + Y ++F+ +S   ++ +        S+++ +YK ++ LET+FRI+D DNSG+IS+DEF+E C++L   +   MT   + D+ARS+D+N DG ID NEFLEAFRI
Sbjct:   78 KDVTDASVEALSIKSALLIQKWYRRYKARLEARRRTTWMIYQSIEYSSEASQLHLYNFFSDMMQLADGKQPQQPQQQHLSPAGSGDPANNRFAERLRQKSLEEEDQELLELTSYEG-IQVEKSYRGPHLSFPLSASHVQVLIDSFRQGTQLHSRYLLQLLHEARLLLKTKPNVYQASTSISRQVTVVGDLHGKLDDLLVIFYKNGLPDVTNPYVFNGDFVDRGANSVETAALLFACLLVWPSAVFINRGNHEDHLMNCRYGFIKEVQAKYKTPANKIVRLFGDTFSWLPLATNIDDKILVTHGGISDKVDMERVQKLDRHQYLSALKPPVSDNENAKVDYKEWRQVLDLLWSDPKPQAGCAPNTFRGGGCYFGPNITEAFLRKHKFSLLVRSHECKPDGWEFCHGGAVLTLFSASNYYEDGSNKGAYAKFDAEGKPHIVQYMASK--ARKLPVGRRLSTVEEGALKDLRAKVIASKTELTAAFQRFDPDKTGSIRLADWCEAMEQTLRLGLPWRTLRPHLAQLAKDGRLLYMTSFDCVSIQTKLGASAGKEVAGSLTEAVYKNKEELETIFRIMDKDNSGQISLDEFQESCRVLTQATGRQMTEAEVGDMARSMDLNSDGYIDFNEFLEAFRI 707          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYE--------NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPS-----DSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            MGC  S   +NG  S +    +E      I ++S I IQKW+R YQAR+EARR+C+W I+QS+EY+GEQDQLKL NFF D++N +   + ++  +  K    S++   S   E        + I +E  Y GP +  PLTL  + ++I  + + ++LH  Y+  +L +TR  LK  PNI      I K ITICGDLHG+L DL  IF +N  P   NPY+FNGD +DRG +SVEIA+ILFSF +LYP  V++NRGNHED IMNLRYGF+KEV  KYK H++ ++ LF DIF WLPLAT+++NKI I HGGISN   L  +  IDR KY+S L  P          D  EW QVLD+LWSDPKP  GC+ N FRGGGCYFGPDIT + L+K+   LL+RSHECK  GYE+ H  +V+TIFSAS+YY+ GSN+GA++K+   + P  + + A K  +KH+ + + I  +EESA+RELR ++  N+  LM+ F   D  N+G +    W + + +VL+LD+PW  LR+QLA V P G + Y S F+    +     H N  S+++ +Y++R  LET+FR++D DNSG +S++EF+E C +L  H+ +N+  +++EDLA+SID++KDG ID NEFLEAFR+
Sbjct:    1 MGCGVS--VENGDDSSVALGKSE------IAIRSAILIQKWFRRYQARIEARRRCTWKIFQSVEYAGEQDQLKLFNFFNDMLNHVADGDNNAVDILRKGSASSSTSTISKTSEKLEMLTDPSKITVEETYKGPHVALPLTLLTVRNIIELYKSHKLLHVKYVLLILRETREKLKVLPNIYRASTRISKQITICGDLHGKLDDLFVIFHKNGLPSAENPYIFNGDLVDRGPYSVEIAIILFSFFLLYPTGVYINRGNHEDHIMNLRYGFVKEVMDKYKEHSSKVMQLFGDIFGWLPLATVVNNKILITHGGISNITDLSFIDKIDRHKYVSILKPPGMDKAHPDTFDLLEWRQVLDLLWSDPKPFPGCKPNTFRGGGCYFGPDITDRILKKHDLELLVRSHECKFEGYEYMHGGKVITIFSASDYYEQGSNRGAYMKIGPDMNPYFVQYQASKA-KKHLTLKQRIGIVEESAIRELRERLYANKIALMAAFEERDKGNTGYLTATQWASAVESVLKLDVPWNMLRHQLAHVLPDGKVEYRSCFD--QYIIETGLHKNGPSITETLYRHRSNLETIFRLMDKDNSGFVSMEEFEECCHLLNEHTNSNIPVDSIEDLAKSIDMDKDGHIDFNEFLEAFRL 626          

Query:  237 KWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLS-------SDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKH--------------------ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP----SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLS---RMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            KWYR Y+ARLEARR+ SWMIYQSIEYS E  QL L+NFF D++ L G            ++ L  +++ +           ++I +E +Y GP + FPL+ T +  +I++F    +LH  YL +LL +TR +LKT+ NI     SI K                     +T+ GDLHG+L+DL+ +  +N  PD +NPY+FNGDF+DRG +SVEI  ILF+  +++P  VFLNRGNHED++MNLRYGFIKEVQ KY+  AN ++N+F+++F W+PLAT+I +++F+ HGGIS+++ L+ ++ +DR +Y+S L  P    SD ++D  EW QVLD+LWSDPK Q+GC+ N FRGGGCYFGP++T  FL+KY ++LL+RSHECK  G+E+CH+D VLT+FSASNYY+ GSNKGA+VK      P+++ F A +  +  +   + + ++EESALR+LR KIL ++S+L+  FL  D + +G I    WC+ M   L+L+LPWRTLR  LA +   G + Y STF+  +   R+   +   N  SV++ +YK R+ LET+FRI+D DNSG+IS++EFKE C+IL   ++  MT + + D+A+S+D+N DG ID NEFLEAFRI
Sbjct:    1 KWYRRYKARLEARRQTSWMIYQSIEYSSESSQLHLYNFFNDMLRLGGGGVGGASANAGFAERLRQRSIEEEDEELLEHTGYSEITVERNYKGPKLSFPLSATHVQLMIDSFRQGGLLHARYLLQLLHETRSVLKTRQNIQLVSSSISKQLDLVIKIFSLNANFHAPILKVTVVGDLHGKLEDLLIVLYKNGLPDVTNPYIFNGDFVDRGPNSVEILAILFACQLVWPSAVFLNRGNHEDQVMNLRYGFIKEVQYKYRQTANKLLNMFSEVFAWMPLATVIDDRVFVTHGGISDKVDLDRVRRLDRHRYVSVLRPPVAKSSDEKVDYMEWRQVLDLLWSDPKAQQGCKPNTFRGGGCYFGPNVTRAFLDKYGYKLLVRSHECKQDGWEFCHEDTVLTVFSASNYYEEGSNKGAYVKFDSECRPRLVQFVASR--RDKLPKGQRLSSVEESALRDLRGKILASKSELIDAFLRLDPEKTGAIRVSQWCSTMEEKLRLELPWRTLRPHLAQLNKDGRLLYMSTFQRAAIQHRLSGGKEMAN--SVTETVYKNREELETIFRIMDKDNSGQISLEEFKESCRILCQATQRQMTEDEVADMAKSLDLNSDGYIDFNEFLEAFRI 615          

Query:  120 MGCQQS-DLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIK----RSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            MGC  S  ++  G  S +  + +  L S  + MK+ I IQ+WYR Y ARLE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q N +   L +  L+ +        R S+YE  +  E+ YSGP + FPL++T    L++AF  +Q LH  Y+ +LL +T+  LK  PN+     S  K ITICGDLHG+L DL+ IF +N  P   NPY+FNGDF+DRGK S+EI +ILF+FL+LYP  + LNRGNHED IMNLRYGF KEV  KYK H   I+ L  D+F  LP+ATII NK+ I HGGIS++  LE L +++R K  SAL  P
Sbjct:    1 MGCGTSVAIENQGRPSEV--DVSARLPSPALTMKAAILIQRWYRRYVARLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFSFMLDNFTQLNGNGPDLISHLLDSAVDPVVDEVRQSKYEQIVVPES-YSGPRLSFPLSVTDTNVLLSAFKEQQTLHAKYVLQLLHETQKFLKQMPNVIYLSSSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSIEIIIILFAFLLLYPDHMHLNRGNHEDHIMNLRYGFTKEVMQKYKTHGREILQLLQDVFSLLPIATIIDNKVLIVHGGISDKTDLEFLASVERQKVKSALRLP 329          

Query: 1086 ALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            AL  P   EL   EW Q++D+LWSDPK Q GC  N FRGGGCYFGPD+T   L+K+   LLIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA++KL   L P+   +   +  +K + + + +   E SAL+ L+ K+ T+RS+LM+ F   D +N+G I    W  ++  VL+LDLPWRTLR +L  +   G + Y S FE +S    +       + ++ +Y+YR  LE +F I+D D+SG+ISI+EF++  K+  +H   ++  +A+ D+AR+ID NKDGSID NEFLEAFR+
Sbjct:  421 ALPEPPREEL---EWRQIVDVLWSDPKIQNGCSPNSFRGGGCYFGPDVTQNLLKKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYIKLGPELIPRFFQYQVSRSTRK-LTLQQRVSVAESSALKALQEKLFTHRSELMAFFQQYDINNTGRISINEWAQVLDTVLRLDLPWRTLRPRLVRLASDGNVEYESCFENISA--GQPLPQVTPNFAETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSAHLGVDVDDQAIVDMARNIDFNKDGSIDFNEFLEAFRV 716          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIK----RSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            + MK+ I IQ+WYR Y ARLE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q N +   L +  L+ +        R S+YE  +  E+ YSGP + FPL++T    L++AF  +Q LH  Y+ +LL +T+  LK  PN+     S  K ITICGDLHG+L DL+ IF +N  P   NPY+FNGDF+DRGK S+EI +ILF+FL+LYP  + LNRGNHED IMNLRYGF KEV  KYK H   I+ L  D+F  LP+ATII NK+ I HGGIS++  LE L +++R K  SAL  P
Sbjct:   18 VAMKAAILIQRWYRRYVARLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFSFMLDNFTQLNGNGPDLISHLLDSAVDPVVDEVRQSKYEQIVVPES-YSGPRLSFPLSVTDTNVLLSAFKEQQTLHAKYVLQLLHETQKFLKQMPNVIYLSSSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSIEIIIILFAFLLLYPDHMHLNRGNHEDHIMNLRYGFTKEVMQKYKTHGREILQLLQDVFSLLPIATIIDNKVLIVHGGISDKTDLEFLASVERQKVKSALRLP 318          

Query: 1086 ALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            AL  P   EL   EW Q++D+LWSDPK Q GC  N FRGGGCYFGPD+T   L+K+   LLIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA++KL   L P+   +   +  +K + + + +   E SAL+ L+ K+ T+RS+LM+ F   D +N+G I    W  ++  VL+LDLPWRTLR +L  +   G + Y S FE +S    +       + ++ +Y+YR  LE +F I+D D+SG+ISI+EF++  K+  +H   ++  +A+ D+AR+ID NKDGSID NEFLEAFR+
Sbjct:  410 ALPEPPREEL---EWRQIVDVLWSDPKIQNGCSPNSFRGGGCYFGPDVTQNLLKKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYIKLGPELIPRFFQYQVSRSTRK-LTLQQRVSVAESSALKALQEKLFTHRSELMAFFQQYDINNTGRISINEWAQVLDTVLRLDLPWRTLRPRLVRLASDGNVEYESCFENISA--GQPLPQVTPNFAETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSAHLGVDVDDQAIVDMARNIDFNKDGSIDFNEFLEAFRV 705          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYE-----NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            M++ + IQ+WYR Y ARLE RR+C+W I+QSIEYSGEQDQ+KL+NFF  LM+       SS+      + + + + + +E+E       I +   Y+GP + FPLT+ +IT L+ AF ++Q LH  Y+ +LL +T  +L+  PNI+E      K ITICGDLHGQL+DL+ +F +N  P    PYVFNGDF+DRGK S+EI +ILF+F ++YP  V LNRGNHED I+NLRYGF KEV  KY+ H   I+ L   IF WLPLAT+I  K+ I HGGIS+   L+ +  ++R++Y+SAL  P
Sbjct:    1 MRAALLIQRWYRQYVARLEMRRRCTWNIFQSIEYSGEQDQIKLYNFFGFLMDHFTPA--SSERNLISHIFRESEVFQDAEWEPYFCYKSIDVPDMYTGPHLTFPLTVNIITELVEAFKHKQHLHARYVLQLLGETWRLLRILPNINEVSTFHSKEITICGDLHGQLEDLLLVFYKNGLPSVETPYVFNGDFVDRGKDSIEILLILFAFQLVYPNDVHLNRGNHEDHIVNLRYGFTKEVLGKYRVHGKKILKLLQKIFSWLPLATVIDQKVLILHGGISDTTDLKLIAKLERNRYVSALRPP 299          

Query: 1110 ELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQL-AVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            E D  EW Q++D+LWSDP  Q GC  N  RGGGCY+GPDIT   L ++  RLLIRSHECK  GYE+CH   VLTIFSASNYY+ GSN+GA+++L   L P ++ + A +   + + + + +   E SALR LR ++  ++S L S +   D +++G+I  +HW      VLQL LPWR LR QL    T  G INY+  F  L+ MD     +    + + +Y++   LET+FRI+D+D+SG IS +EF++  K+L SH K  ++ +A+ DLA SID NKDGSID+NEF+EAFR+
Sbjct:  398 ETDAEEWKQIVDMLWSDPMSQDGCIPNEVRGGGCYWGPDITEDVLNRHNLRLLIRSHECKQDGYEFCHNRRVLTIFSASNYYEVGSNRGAYIRLGPDLNPHVVQYQASRS-TRELTLRQSVGRTERSALRALREQVFAHKSDLTSAYEEFDPEHTGVISMKHWAVATETVLQLGLPWRVLREQLVGDSTQDGIINYNDWFRELALMDPN-TELAHTGLLETMYRHHSNLETIFRIIDTDHSGLISFEEFRQTWKLLSSHLKMEISDKAISDLALSIDFNKDGSIDINEFMEAFRL 690          

Query: 1119 QAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDN 2003
            Q EW Q+LD+LWSDP    GC  N  RGGGCY+GP++T +FL K+  +L+IRSHECK  GYE+CH  +VLTIFSASNYY+ GSN+GAFV+L   L P  I + A     + + + + +   E SAL+ LR ++  ++S LMS F   D +N+GLI    W + M+ VL LDLPWR LR+QL   T    ++Y + F  L+  +    H+ + ++ D +YK+R TLET+FRI+D+DNSG IS ++F++  K+L ++ K  ++ E++ DL  SID NKDG+ID++EF+E+FR+ + N
Sbjct:  439 QNEWKQILDLLWSDPMIPDGCVPNEVRGGGCYWGPNVTEEFLNKHSMQLIIRSHECKQDGYEFCHNRKVLTIFSASNYYEVGSNRGAFVRLGPDLVPYFIQYQANS-MTREMSVRQSLRRTEHSALKVLREQLFAHKSDLMSAFQQHDKENTGLISLSDWGSAMSQVLHLDLPWRMLRSQLITTTTDDMLDYHNWFRNLAIKEKSYEHIEQ-TLLDTLYKHRSTLETIFRIVDTDNSGFISFEDFRQTWKLLNAYLKMEISEESINDLVVSIDTNKDGNIDIDEFMESFRLVDKN 731          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM----GQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            +++ + IQ+WYR Y AR+E RR+ +W I+QSIEY+G+QDQ+KL+NF   L++       ++NL S       + +    +R  +Y + I +   YSGP + FPL       L+ AF ++Q LH  Y+ +LL +T  +L+  PNI+       K ITICGDLHGQL+DL+ IF +N  P     YVFNGDF+DRGK S+EI +ILF+FL++YPG V LNRGNHED I+NLRYGF KEV  KYK H   I+ L   IF WLPLAT+I  K+ I HGGIS+   L  +  +DR KY+S+L  P
Sbjct:   33 IRAAVLIQRWYRQYVARMELRRRYTWNIFQSIEYAGQQDQIKLYNFLGYLVDNFTPSSNERNLISHIFRENEVCRDIEWERFFDYRH-IEVPDIYSGPRLTFPLNADQAADLVEAFRSKQQLHSRYVLQLLGETWKLLRVLPNINRISTCHSKEITICGDLHGQLEDLLLIFYKNGMPSMEKAYVFNGDFVDRGKDSIEILLILFAFLLVYPGEVHLNRGNHEDHIINLRYGFTKEVLGKYKMHGKRILKLLQKIFSWLPLATVIDQKVLIVHGGISDTTDLALVARVDRHKYVSSLRPP 331          

Query:  405 FTKALNKSTSIKRSSEYENDI---PLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            F +A+  S  +KRS     DI    +E +Y+GP ++   +TL  +  +++ F +++ LH    +++LVQ + +L   P++ E  L   + ITICGD HGQ  DL+ IFE N  P P+NPY+FNGDF+DRG  S+E+ + LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F+WLPLA  I++K+ + HGG+   + + L+ L+ IDR++       P DS         + D+LWSDP+PQ G R    RG  C FGPD+T +FLE+ K + ++RSHE K  GYE  H  + +T+FSA NY D   NKGA++ L  S L+P+   F A
Sbjct:  141 FERAI-ASDELKRSVVDSLDIENMTIEDEYAGPKLEDGKVTLKFMKEMMDWFKDQKKLHRKCAYQMLVQVKEVLSKLPSLVEITLKETEKITICGDTHGQYYDLLNIFELNGLPSPTNPYLFNGDFVDRGSFSMEVILTLFGFKLLYPDHFHLLRGNHETDNMNQMYGFEGEVKAKYTAQ---MFQLFSEVFQWLPLAQCINSKVLVMHGGLFSEDGVTLDDLRKIDRNRQ------PPDSG-------PMCDLLWSDPQPQNG-RSISKRGVSCQFGPDVTQRFLEQNKLQYIVRSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTA 471          

Query:  459 NDIPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKH--ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLT-KSLEPKIISFNA 1430
            + + +E DY+GP +    +T+T +  LI  F +++ LH  Y +++L+Q +  L+  P++ E  +   +   IT+CGD+HGQ  DL++IFE N  P  +NPYVFNGDF+DRG  SVE+ ++LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    + + F+++F+WLPLA  I++++ I HGG+   + + L+ ++ IDR++       P DS         + D+LWSDP+PQ G R    RG  C FGPD++  F+E+    L+IRSHE KP GYE  H    +T+FSA NY D   NKG+++ LT  +L+P+   F A
Sbjct:  128 DSMAIEDDYTGPKVDNGQVTITFMKELIEWFKDQKKLHRKYAYQILLQVKQSLQKLPSLVEVTIKDEQGDMITVCGDIHGQYFDLLHIFELNGLPSETNPYVFNGDFVDRGSWSVEVILVLFGFKLLYPDHFHLMRGNHETDNMNQMYGFEGEVKAKYTAQ---MFDFFSEVFQWLPLAMCINSRVLIMHGGLFSEDGVTLDDIRKIDRNRQ------PPDSG-------PMCDLLWSDPQPQPG-RSVSKRGVSCQFGPDVSRAFMEQNNLELIIRSHE-KPDGYEVAHDGRCVTVFSAPNYCDQMGNKGSYIHLTAPALKPEFHEFAA 439          

Query:  552 NEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHA 1478
            N Q+  G  +  L +++R I  ++P + E +  +     ICGD+HGQ  DL+ +FE   +P  SN Y+F GD++DRGK S+E   +L ++ I YP   FL RGNHE  I N  YGF  E + +Y      +   F D F  LP+A I+  KIF CHGG+S  +Q +E ++ I R         P+D   DQ     + D+LWSDP K   G  +N  RG    FG ++  +FL K+   L+ R+H+    GYE+  K +++T+FSA NY     N GA + + ++L   + SF   K   K      G++A
Sbjct:    9 NVQLTEGE-IRGLCLKSREIFLSQPILLELEAPL----KICGDIHGQYYDLLRLFEYGGFPPESN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEASI-NRIYGFYDECKRRYNI---KLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMR---------PTDVP-DQG---LLCDLLWSDPDKDTMGWGEND-RGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETL---MCSFQILKPADKKKFPYVGLNA 292          

Query:  675 GDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSL--EPKIISFNAKKEFQKHILINEGIHAIEESALRELRTK 1514
            GD+HGQ  DL+ +FE   +P  +N Y+F GD++DRGK S+E   +L ++ I YP   FL RGNHE   +N  YGF  E + ++      +   F D F  LP+A I+  KIF CHGG+S  +Q +E ++ I R         P+D   D  +   + D+LWSDP K  +G  +N  RG    FG D+  +FL ++   L+ R+H+    GYE+  K +++T+FSA NY     N G  + + ++L    +I+  + KK   ++  +N G       A   L  K
Sbjct:    1 GDIHGQYTDLLRLFEYGGFPPEAN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNI---KLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMR---------PTDVP-DTGDAGLLCDLLWSDPDKDVQGWGEND-RGVSFTFGGDVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGMNSGRPVTPPKAAVPLPKK 269          

Query:  636 ETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-------KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDE------VLTIFSASNYYDTGSNKGAFVK 1388
            +T + I   +T+CGD+HGQ  DL+ +FE    P  +  Y+F GD++DRG  S+E  + L++  ILYP  +FL RGNHE + +   + F +E + KY     ++ +   D F  LPLA +++ +    HGG+S  +  LE ++ +DR K   A                + D+LWSDP       K Q+    N  RG   ++       FL+      +IR+HE +  GY    K +      ++TIFSA NY D  +NK A +K
Sbjct:   59 KTMIDIEAPVTVCGDIHGQFFDLMKLFEVGGSPANTR-YLFLGDYVDRGYFSIECVLYLWALKILYPTTLFLLRGNHECRHLTEYFTFKQECKIKY---TETVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEVHNLEDIRKLDRFKEPPAFG-------------PMCDLLWSDPSEDFGNEKTQEYFCHNTVRGCSYFYSYPAVCDFLQNNNLLSVIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLK 306          

Query:  588 LLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-KPQKGCRQNLFRGGGCYFGPDITHQF 1241
            L +++R I  ++P + E +  +     ICGD+HGQ  DL+ +FE   +P  SN Y+F GD++DRGK S+E   +L ++ I YP   FL RGNHE   +N  YGF  E + ++      +   F D F  LP+A I+  KIF CHGG+S  +Q +E ++ I R   +       D+ L       + D+LWSDP K  +G  +N  RG    FG D+  +F
Sbjct:   24 LCIKSREIFLSQPILLELEAPL----KICGDIHGQYTDLLRLFEYGGFPPESN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNI---KLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDV------PDTGL-------LCDLLWSDPDKDVQGWGEND-RGVSFTFGADVVSKF 221          

Query:  477 TDYSGPIIQFP----------------LTLTVITSLINA-FNNEQILHGHYLFELLVQTRGILKTKPNISE--TDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISN--RIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLT 1394
             +Y GP ++F                 ++   I+ ++N  F   + L   Y+  ++     + + +P++ E   + +    I++CGD HGQ  D++ +F +     P + Y+FNGDF+DRG  S E+A++ +   IL+P   FLNRGNHE   MN  YGF  E + KY   +  I N+FA  F  LPLAT+I+N   + HGG+ +     L   KNIDR         P D           +++LW+DP+   G   +  RG G  FGPDIT +FL   K R + RSHE +  G ++  K +++T+FSA NY D+  N G  + + 
Sbjct:  163 ANYEGPKLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKY---SQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDFKNIDRFA-----QPPRDGAF--------MELLWADPQEANGMGPSQ-RGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVV 472          

Query:  588 LLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRI-QLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEG 1469
            L  + R I   +P + E +  I     ICGD+HGQ  DL+ +FE   +P  SN Y+F GD++DRGK S+E   +L ++ I YP   F+ RGNHE   +N  YGF  E + +Y      +   F D F  LP+A II  KIF  HGG+S  +  +E ++ + R   I  +               + D+LWSDP K   G  +N  RG    FGPD+ ++FL+K    L+ R+H+    GYE+  K +++T+FSA NY     N GA + + +SL   + SF   K  QK +    G
Sbjct:   37 LCSKARSIFIKQPILLELEAPI----KICGDIHGQYYDLLRLFEYGGFPPESN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNI---KLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGL-------------LCDLLWSDPDKDIVGWSEND-RGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESL---LCSFQILKPAQKSLPRQAG 307          

Query:  663 ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNA 1430
            +TICGD+HGQ  DL+ +F+    P P   Y+F GD++DRG +SVE    L +  + YP  + + RGNHE + +   YGF  E   KY + AN +  +F D+F + P+  ++ NKIF  HGG+S  I+ ++ +++++R + +     P +  +         D+LWSDP  + G   +  RG G  FG DI+ QF       L+ R+H+    GY W H+  V+TIFSA NY     N+ A +++ ++   + + ++ 
Sbjct:  120 VTICGDVHGQFHDLLELFKIGG-PCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGS-AN-VWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEV-----PHEGPM--------CDLLWSDPDDRGGWGISP-RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP 359          

Query:  663 ITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNA 1430
            +TICGD+HGQ  DL+ +F+    P P   Y+F GD++DRG +SVE    L +  + YP  + + RGNHE + +   YGF  E   KY + AN +  +F D+F + P+  ++ NKIF  HGG+S  I+ ++ ++ ++R + +     P +  +         D+LWSDP  + G   +  RG G  FG D++ QF       L+ R+H+    GY W H+  V+TIFSA NY     N+ A +++ ++   + + ++ 
Sbjct:  112 VTICGDVHGQFHDLLELFKIGG-PCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGS-AN-VWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEV-----PHEGPM--------CDLLWSDPDDRGGWGISP-RGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP 351          

Query:  579 LFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGIS-NRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNA 1430
            +F L + ++ +L  + N+++ D  +    TICGD+HGQL DL+ +FE++   + +  Y+F GDF+DRG +S+E  ++L  + + YP  + L RGNHE + +   YGF  EV  KY    +++     ++F +L L  II+N IF  HGG+S +   ++ ++ IDR + +     P +  +         D+LWSDP+       +  RG G  FG     QFLEK    L+ R+H+    GY+      ++T++SA NY     N  A +K+   L  +   F A
Sbjct:   22 VFRLCLNSQELLMNEGNVTQVDTPV----TICGDIHGQLHDLLTLFEKSGGVEKTR-YIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYG--NSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEV-----PHEGAM--------CDLLWSDPEDVDTWSLSP-RGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEA 285          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM-------GQQNLSSDSLFTKALNKSTSIKRSSEYE-----NDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP-----SDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            ++S + IQ W+R Y+ARLEARR+C+W I+QSIEYSGEQDQLKL NFF D++  +        + N+  D+L       STS K S+  E     +DI +E  Y+G +++ P+TL  + ++I      +++H  Y+  +L + R   +  PN+      I K +TICGDLHG+L DL  IF +N  P P NPY+FNGD +DRG  S+EI +ILF+F ILYP  V++NRGNHED IMNLRYGF+KEV  KYK HA+ II LF DIF WLPLATI++NKIF+ HGGISN   L+ ++ IDR KY+S L  P     + S     EW QVLD+LWSDPKP  GC+ N FRGGGCYFGPD+T Q L K+ F LL+RSHECK  GYE+ H  +V+TIFSASNYY+ GSN+GA++K+   + P  + +   +  +KH+ + + +  +EESA+REL+ K+  N+S LM  F   D  ++G + C  W   + + L LD+PW  LR+QLA V P G ++Y S  E  + ++ K    N  S+++ +Y+ R  LET+FR++D DNSG +S++EF+  C++L  HS+  +  ++++DLARSID++KDG ID NEFLEAFR+
Sbjct:   29 LRSAVLIQNWFRRYRARLEARRRCTWKIFQSIEYSGEQDQLKLFNFFTDMLTHVQPDNTGASRANIIEDTLSRNGSASSTSSKSSTTLEAATDPSDIKVEPTYTGHVVKLPITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLDIIERIDRHKYVSVLKPPNIVKDNPSLSSLKEWRQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQYQVSRT-KKHLTLKQRVGIVEESAIRELKEKLYANKSALMEAFTKRDEQHTGYLTCSQWAAAIESTLHLDVPWNMLRHQLAYVAPDGKVDYRSCLEQYA-IEGKTKK-NGPSITEALYRNRSNLETIFRLMDKDNSGHVSMEEFQASCRLLNQHSETEIPEDSIQDLARSIDMDKDGYIDFNEFLEAFRL 635          

Query:  588 LLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHA 1478
            L +++R I  ++P + E +  +     ICGD+HGQ  DL+ +FE   +P  SN Y+F GD++DRGK S+E   +L ++ I YP   FL RGNHE   +N  YGF  E + +Y      +   F D F  LP+A I+  KIF CHGG+S  +Q +E ++ I R         P+D   DQ     + D+LWSDP K  +G  +N  RG    FGPDI  +FL K+   L+ R+H+    GYE+  K +++T+FSA NY     N GA + + ++L   + SF   K   K      G+++
Sbjct:   38 LCLKSREIFLSQPILLELEAPL----KICGDIHGQYYDLLRLFEYGGFPPESN-YLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI---KLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMR---------PTDVP-DQG---LLCDLLWSDPDKDVQGWGEND-RGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETL---MCSFQILKPADKKKFPYGGLNS 311          

Query:  555 EQILHGHYLFELLVQT-----RGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFE-ENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFN-AKKEFQKHI 1454
            EQ++    L E  V+T     + IL  + N+ E    +    T+CGD+HGQ  DL+ +F    + PD +  Y+F GD++DRG +SVE   +L +  + +P  + + RGNHE + +   YGF  E   KY     S+   F D+F +LPL  ++ N+IF  HGG+S  I  L+ ++ +DR + +     P +  +         D+LWSDP  + G   +  RG G  FG DI+  F       L+ R+H+    GY WCH   V+TIFSA NY     N+ A ++L  +L+   + F+ A +  + H+
Sbjct:   16 EQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPV----TVCGDVHGQFHDLMELFRIGGKSPDTN--YLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGN--ASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEV-----PHEGPM--------CDLLWSDPDDRGGWGISP-RGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRRGEPHV 301          

Query:  537 INAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKE 1439
            I    N +++    + +L  + R IL  + N+   D      +T+CGD+HGQ  DL  +F+      P   Y+F GDF+DRG +SVE  ++L +  + YP  + L RGNHE + +   YGF  E   KY   + ++    A+IF +L L+ II N++F  HGG+S  I  L+ +++IDR + +     P D  +         D+LWSDP+  +G   +  RG G  FG D+  Q+       L+ R+H+    GY+W   + VLT++SA NY     N  A ++L + L+ +   F A  +
Sbjct:   11 IEKLRNCELITEKEVKQLCAKAREILVEESNVQRVD----SPVTVCGDIHGQFYDLKELFKVGG-DVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYG--SITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEV-----PHDGPM--------CDLLWSDPEDIQGWGVSP-RGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQ 291          

Query:  540 NAFNNEQILHGHYLFELLVQTRGILKTKPNIS------ETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQ-LETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDP-------KPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDE------VLTIFSASNYYDTGSNKGAFVK 1388
            N      +L  H++ E  V+    LK   + +      +T L +   IT+CGD+HGQ  DL+ +FE    P  +  Y+F GD++DRG  S+E  + L++   LY   +FL RGNHE + +   + F  E + KY   + ++ +   + F  LPLA +++ +    HGG+S  I  L+ +K +DR K   A                + D+LWSDP       K  +    N  RG   ++    T +FL+      +IR+HE +  GY    K +      ++TIFSA NY D  +NK A +K
Sbjct:   16 NGKPRADVLKAHFILEGRVEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTR-YLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKY---SEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFG-------------PMCDLLWSDPLEDYGNEKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLK 301          

Query: 1080 ISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKIS--VSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +S++  PS  + +Q EW Q++DILWSDPK Q+GC  NLFRGGGCYFGPD+T + L ++  ++LIRSHECK  GYE CH  +V+TIFSASNYY+ GSN+GA++KL + L P+   +   +   + + + + I A E SALR L+ K+  +RS+L+  F   D DN+G +    W  ++  VL+LDLPWRTLR  LA +   G++ Y S FE +    +    + K++  +++ +++YR  +E +F I+D D+SG ISI+EF+   ++  +H    +   A++DLARSID NKDGSID  EFLEAFR+
Sbjct:  426 LSSIPLPSPPQHEQ-EWKQIVDILWSDPKTQEGCSPNLFRGGGCYFGPDVTQKLLLQHGLQMLIRSHECKQEGYEICHGGKVITIFSASNYYEEGSNRGAYIKLGRELVPRFYQYQVSR-ITRKLTLTQRIRAAEGSALRALKEKLFAHRSELVGSFQQYDPDNTGTVSVCEWAQVLECVLRLDLPWRTLRPHLARLASDGSVEYQSCFEDMEPGAT----LPKVTPNLAETLFRYRTDIEIIFNIIDKDHSGLISIEEFRHTWRLFSAHLGVAIDDRAIDDLARSIDFNKDGSIDFTEFLEAFRV 725          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTS--IKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            MGC  S   +  +  +   E      S  + +K+ + IQ+WYR Y ARLE RR+ +W I+QSIEY+GEQDQL+L +FF  +++   Q + +   L T+ L+      + R   Y N +P+   Y+GP I FPL ++   +L++AF  +QILH  Y+ +LL + + +LK  PNI+    S  K ITICGDLHG L DL+ IF +N  P    PYVFNGDF+DRGK SVE+ ++LF++ +LYP  + LNRGNHED IMNLRYGF KEV  KYK H   I+ LF D+F  LP+AT+I  K+ I HGGIS++  L  L +I R K  SAL  P
Sbjct:    1 MGCGTSVATETQLKKLETDEAGRT-PSLALTIKAAVLIQRWYRRYMARLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFSFMLDNFTQLSGNGPDLITQLLDPVVDPWLDREICY-NLVPVPDSYTGPRISFPLGVSDTNTLLSAFKEQQILHARYVLQLLYEAKKLLKQMPNINHLSTSYTKDITICGDLHGHLDDLLLIFYKNGLPSAETPYVFNGDFVDRGKKSVEVVIMLFAYFLLYPDYMHLNRGNHEDPIMNLRYGFTKEVMQKYKIHGREILQLFQDVFSLLPIATVIDGKVLIVHGGISDQTDLNLLSSIKRHKVKSALRFP 327          

Query: 1086 ALNCPSDS---ELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPS-GAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            ALN  +DS   +    EW Q+LD+LWSDP  Q GC+ N  RGGGCY+GPDIT  FL ++  +L+IRSHECK  GYE+CH   VLT+FSASNYYD GSN+GA+VK+   LEP +I + A     + +   + I   E SAL+ LR ++  ++S L+  F   D +N+GL+    W   + +V+ L+LPWR LR QL     S G I+Y++ F  L+      +H+ + ++ + +Y++R TLET+FRI+D+DNSG IS+++F++  K+L  + K  +T EA+ DLA +ID N+DGSID++EF+EAFR+ +
Sbjct:  366 ALNVSTDSVRSDNSNEEWRQILDLLWSDPMTQNGCKPNEVRGGGCYWGPDITEDFLNRHNMQLIIRSHECKQEGYEFCHNRRVLTLFSASNYYDVGSNRGAYVKMGPDLEPYVIQYQASS-MTRELTAKQSIGRTERSALKVLREQLFAHKSDLICAFRGFDTENAGLVSLSDWACAVESVMHLNLPWRMLRCQLVTCKGSDGMIDYNAWFHELAIKGPNTDHIEQ-TLLETLYRHRSTLETIFRIVDTDNSGFISMEDFRQTWKLLSVYLKMEITDEAISDLAVTIDSNQDGSIDIDEFMEAFRLTD 671          

Query:  273 RRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYEN-----DIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            RR+ +W I+QSIEYSGEQ Q+KL+NF   LM+       SS+      + +   I R +E+E      +I +   YSGP + FPLTL     L++AF N++ LH  Y+ +LL++T  +L+  PNI+       K +TICGDLHGQL+DL+ IF +N  P    PYVFNGDF+DRGK S+EI +ILFSFL++YP  V+LNRGNHED I+NLRYGF KEV TKY+ H   I+ L   IF WLPLAT+I  K+ + HGGIS+   L  L  +DR  Y+SAL  P
Sbjct:    2 RRRYTWNIFQSIEYSGEQAQIKLYNFLGYLMDNFTPS--SSERNLISHIFRENDICRDAEWERYFCYKNIEVPEVYSGPHLTFPLTLEQAIGLLDAFRNKKQLHSRYVLQLLLETWRLLRMLPNINRISTCHSKEVTICGDLHGQLEDLLLIFYKNGMPSLEKPYVFNGDFVDRGKDSIEILLILFSFLLIYPSDVYLNRGNHEDHIINLRYGFTKEVLTKYRVHGKRILKLLQKIFSWLPLATVIDQKVLVLHGGISDTTDLAVLAKLDRHSYVSALRPP 280          

Query: 1086 ALNCPSDS---ELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPS-GAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINE 1997
            ALN  +DS   +    EW Q+LD+LWSDP  Q GC+ N  RGGGCY+GPDIT  FL ++  +L+IRSHECK  GYE+CH   VLT+FSASNYYD GSN+GA+VK+   LEP +I + A     + +   + I   E SAL+ LR ++  ++S L+  F   D +N+GL+    W   + +V+ L+LPWR LR QL     S G I+Y++ F  L+      +H+ + ++ + +Y++R TLET+FRI+D+DNSG IS+++F++  K+L  + K  +T EA+ DLA +ID N+DGSID++EF+EAFR+ +
Sbjct:  403 ALNVSTDSVRSDNSNEEWRQILDLLWSDPMTQNGCKPNEVRGGGCYWGPDITEDFLNRHNMQLIIRSHECKQEGYEFCHNRRVLTLFSASNYYDVGSNRGAYVKMGPDLEPYVIQYQASS-MTRELTAKQSIGRTERSALKVLREQLFAHKSDLICAFRGFDTENAGLVSLSDWACAVESVMHLNLPWRMLRCQLVTCKGSDGMIDYNAWFHELAIKGPNTDHIEQ-TLLETLYRHRSTLETIFRIVDTDNSGFISMEDFRQTWKLLSVYLKMEITDEAISDLAVTIDSNQDGSIDIDEFMEAFRLTD 708          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYEN-----DIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            +++ + IQ+WYR Y AR E RR+ +W I+QSIEYSGEQ Q+KL+NF   LM+       SS+      + +   I R +E+E      +I +   YSGP + FPLTL     L++AF N++ LH  Y+ +LL++T  +L+  PNI+       K +TICGDLHGQL+DL+ IF +N  P    PYVFNGDF+DRGK S+EI +ILFSFL++YP  V+LNRGNHED I+NLRYGF KEV TKY+ H   I+ L   IF WLPLAT+I  K+ + HGGIS+   L  L  +DR  Y+SAL  P
Sbjct:   19 IRAAVLIQRWYRQYVARTEMRRRYTWNIFQSIEYSGEQAQIKLYNFLGYLMDNFTPS--SSERNLISHIFRENDICRDAEWERYFCYKNIEVPEVYSGPHLTFPLTLEQAIGLLDAFRNKKQLHSRYVLQLLLETWRLLRMLPNINRISTCHSKEVTICGDLHGQLEDLLLIFYKNGMPSLEKPYVFNGDFVDRGKDSIEILLILFSFLLIYPSDVYLNRGNHEDHIINLRYGFTKEVLTKYRVHGKRILKLLQKIFSWLPLATVIDQKVLVLHGGISDTTDLAVLAKLDRHSYVSALRPP 317          

Query:  213 MKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMN----LMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCP 1100
            +++ + IQ+WYR Y ARLE RR+C+W I+QSIEY+GEQDQ+KL++FF  LM+       ++NL S       + + T  +R   Y+ DI +   Y+GP + FP+T   ++ L+ AF ++Q LH  Y+ ++L +T  +L+  PNI+   +S  K ITICGDLHGQL+DL+ IF +N  P    PY+FNGDF+DRGK S+EI +ILF FL++YP  + LNRGNHED I+NLRYGF KE+  KY+ H   I+ L   IF WLPLAT+I++K+ + HGGISN   L  +  +DR +Y+S L  P
Sbjct:   26 IRAALLIQRWYRQYVARLEMRRRCTWNIFQSIEYAGEQDQIKLYSFFGFLMDHFTPASSERNLISHIFHENEICRDTEWERYFCYK-DIEVPDSYTGPHLTFPMTFCGVSKLVEAFKHKQQLHARYVLQILGETWRLLRILPNINYVSVSQTKEITICGDLHGQLEDLLLIFYKNGLPSSEKPYIFNGDFVDRGKSSLEILLILFGFLLVYPNDLHLNRGNHEDHIVNLRYGFTKEILGKYRVHGKKILKLLQKIFSWLPLATVINDKVLVVHGGISNSTDLCVVSRVDRHRYVSVLRPP 324          

Query: 1101 SDSELDQAE--------WLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            SDS+ D AE        W Q++++LWSDP PQ GC  N  RGGGCY+GPD+T + L ++  +LLIRSHECK  GYE+CH   VLTIFSASNYY+ GSN+GA++++   L P +I + A +  ++ + + + +   E SALR LR ++  ++S L+  +   D   +G I  +HW +   +VL+L LPWR LR+QL   T  G ++Y    + LS  + K   ++  S+ + +YK    LET+FRI+D+D+SG IS++EF++  K+L SH K  ++ +A+ DLA SID NKDGSID+NEF+EAFR+
Sbjct:  408 SDSDPDFAEASKANGHDWKQIVNLLWSDPMPQNGCISNEVRGGGCYWGPDVTEEVLGRHNLQLLIRSHECKQDGYEFCHNRRVLTIFSASNYYEVGSNRGAYIRMGADLVPHLIQYQASRTCRE-LTLRQSVGWTERSALRALREQLFVHKSDLIRAYQEFDPHQTGKISMRHWASATESVLKLGLPWRVLRSQLVSRTHYGMVDYQQWIKELSITEPKLE-VSDTSILETMYKNHSNLETIFRIIDTDHSGLISLEEFRQTWKLLSSHLKMEISDKAIADLAHSIDFNKDGSIDINEFMEAFRL 710          

Query:  465 IPLETDYSGPIIQ-FPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGI--SNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKS-LEPKIISFNA 1430
            + +E DY+GP ++   +T++ +T ++  F  ++ LH    +++LVQ + +L   P++ E  L     +TICGD HGQ  DL+ IF+ N  P  +NPY+FNGDF+DRG  S+E+ + LF F +LYP    L RGNHE   MN  YGF  EV+ KY A    +  LF+++F+WLPLA  I++K+ + HGG+   + + L+ ++ IDR++       P DS         + D+LWSDP+PQ G R    RG  C FGPD+T  FLEK K   +IRSHE K  GYE  H  + +T+FSA NY D   NKGA++ L  S L+P+   F A
Sbjct:  162 MTIEDDYAGPKLEDGKVTVSFMTDMMEWFKEQKKLHRKCAYQILVQVKDVLSKLPSLVEITLKETDKLTICGDTHGQYYDLLNIFKLNGLPSDANPYLFNGDFVDRGSFSLEVILTLFGFKLLYPDNFHLLRGNHETDNMNQMYGFEGEVKAKYTAQ---MFQLFSEVFQWLPLAQCINSKVLVMHGGLFSEDGVTLDDIRKIDRNRQ------PPDSG-------PMCDLLWSDPQPQNG-RSVSKRGVSCQFGPDVTESFLEKNKLDYIIRSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTA 470          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ 2009
            MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ
Sbjct:    1 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ 630          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ 2009
            MGCQQSDLKKNGIASVLLREDNEDLK    MMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ
Sbjct:    1 MGCQQSDLKKNGIASVLLREDNEDLK----MMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDSELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRINEDNYQ 626          

Query:  120 MGCQQSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM--GQQNLSSDSLFTKALNKSTSIKRSSEYEND------------IPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSD---SELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            MGC QS+  K+         + +++ +    +K+ I IQ WYR Y+A+LEA+R+ +WMIYQSIEYSGEQDQLKL +FF DL++L   GQ+    DS   +AL+K+  +K +    ++            I +E  Y G  + FPL++  +T+LI +F  EQILH  YL ELL  TR +LKTKPN+S+   SI K +TICGDLHGQL DL+ IF +N++PD SNPY+ NGDF+DRG HSVEIA ILFSF +LYP  VFLNRGNHED +MN RYGF+KE+Q KYK++AN I+  FADIF WLPL TII N I +CHGGIS  + L+ ++ +DR K++S L  P +   +E  + EW+Q+LD+LWSDP+ + GC  N +RGGGCYFGPDIT+  L+KY   LLIRSHECK  GYEWCH+++V+T+FSASNYY  GSNKGAF+++      +   +   K+ QKH+ + + ++ IEESALR+L+ KIL  +++L  EF+  D +N G+IE Q WC +M  VL+L LPWRTLR  L  ++  G + YSS FE   ++D+K   M   ++++E+YK ++ LET+FRI+D DNSG IS+ EF++ CK+L  H+  N++ EA+EDLA+ +DINKDG ID NEFLEAFRI
Sbjct:    1 MGCAQSNSPKH---------EYDNIYNSPKAIKAAILIQNWYRRYRAKLEAKRRYTWMIYQSIEYSGEQDQLKLQSFFNDLLSLTNKGQE---CDSEVIEALSKTHVLKTAPTVSDEDRDLQYLTKIEQIVVEPTYKGAKLTFPLSINQVTALIESFRKEQILHARYLLELLDHTRNLLKTKPNVSQASTSISKRVTICGDLHGQLDDLVTIFYKNKFPDTSNPYIINGDFVDRGSHSVEIAAILFSFFLLYPQSVFLNRGNHEDHVMNYRYGFVKEIQIKYKSNANKIVRFFADIFSWLPLMTIIDNSILVCHGGISAMLNLDVIEKLDRHKFLSVLQAPVEDIKNENKEEEWMQILDLLWSDPRSKPGCSVNQYRGGGCYFGPDITNDILKKYNLSLLIRSHECKIDGYEWCHENKVVTLFSASNYYKQGSNKGAFLRIDNEHNKQFFQYTTHKKNQKHLTLIQSVNQIEESALRDLKGKILAFKNELAEEFIQKDVNNRGVIELQEWCTVMENVLKLPLPWRTLRPHLVKLSKEGKVEYSSIFE-AQQVDNK-FLMIAGTMTEELYKNKENLETIFRIMDKDNSGHISLSEFRDACKLLHRHTNRNVSEEAIEDLAKCLDINKDGQIDFNEFLEAFRI 627          

Query:  207 IMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLM--GQQNLSSDSLFTKALNKSTSIKRSSEYEND------------IPLETDYSGPIIQFPLTLTVITSLINAFNNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSD---SELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKKEFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDNSGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEIYKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            I +K+ I IQ WYR Y+A+LEA+R+ +WMIYQSIEYSGEQDQLKL +FF DL++L   GQ+    DS   +AL+K+  +K +    ++            I +E  Y G  + FPL++  +T+LI +F  EQILH  YL ELL  TR +LKTKPN+S+   SI K +TICGDLHGQL DL+ IF +N++PD SNPY+ NGDF+DRG HSVEIA ILFSF +LYP  VFLNRGNHED +MN RYGF+KE+Q KYK++AN I+  FADIF WLPL TII N I +CHGGIS  + L+ ++ +DR K++S L  P +   +E  + EW+Q+LD+LWSDP+ + GC  N +RGGGCYFGPDIT+  L+KY   LLIRSHECK  GYEWCH+++V+T+FSASNYY  GSNKGAF+++      +   +   K+ QKH+ + + ++ IEESALR+L+ KIL  +++L  EF+  D +N G+IE Q WC +M  VL+L LPWRTLR  L  ++  G + YSS FE   ++D+K   M   ++++E+YK ++ LET+FRI+D DNSG IS+ EF++ CK+L  H+  N++ EA+EDLA+ +DINKDG ID NEFLEAFRI
Sbjct:   47 ISIKAAILIQNWYRRYRAKLEAKRRYTWMIYQSIEYSGEQDQLKLQSFFNDLLSLTNKGQE---CDSEVIEALSKTHVLKTAPTVSDEDRDLQYLTKIEQIVVEPTYKGAKLTFPLSINQVTALIESFRKEQILHARYLLELLDHTRNLLKTKPNVSQASTSISKRVTICGDLHGQLDDLVTIFYKNKFPDTSNPYIINGDFVDRGSHSVEIAAILFSFFLLYPQSVFLNRGNHEDHVMNYRYGFVKEIQIKYKSNANKIVRFFADIFSWLPLMTIIDNSILVCHGGISAMLNLDVIEKLDRHKFLSVLQAPVEDIKNENKEEEWMQILDLLWSDPRSKPGCSVNQYRGGGCYFGPDITNDILKKYNLSLLIRSHECKIDGYEWCHENKVVTLFSASNYYKQGSNKGAFLRIDNEHNKQFFQYTTHKKNQKHLTLIQSVNQIEESALRDLKGKILAFKNELAEEFIQKDVNNRGVIELQEWCTVMENVLKLPLPWRTLRPHLVKLSKEGKVEYSSIFE-AQQVDNK-FLMIAGTMTEELYKNKENLETIFRIMDKDNSGHISLSEFRDACKLLHRHTNRNVSEEAIEDLAKCLDINKDGQIDFNEFLEAFRI 653          

Query:  117 LMGCQ-QSDLKKNGIASVLLREDNEDLKSKLIMMKSVIAIQKWYRGYQARLEARRKCSWMIYQSIEYSGEQDQLKLHNFFLDLMNLMGQQNLSSDSLFTKALNKSTSIKRSSEYENDIPLETDYSGPIIQFPLTLTVITSLINAF---NNEQILHGHYLFELLVQTRGILKTKPNISETDLSIFKHITICGDLHGQLQDLIYIFEENRYPDPSNPYVFNGDFIDRGKHSVEIAVILFSFLILYPGCVFLNRGNHEDKIMNLRYGFIKEVQTKYKAHANSIINLFADIFRWLPLATIISNKIFICHGGISNRIQLETLKNIDRSKYISALNCPSDS--ELDQAEWLQVLDILWSDPKPQKGCRQNLFRGGGCYFGPDITHQFLEKYKFRLLIRSHECKPLGYEWCHKDEVLTIFSASNYYDTGSNKGAFVKLTKSLEPKIISFNAKK--EFQKHILINEGIHAIEESALRELRTKILTNRSQLMSEFLACDGDN----SGLIECQHWCNIMAAVLQLDLPWRTLRNQLAVVTPSGAINYSSTFELLSRMDSKQNHMNKISVSDEI-YKYRDTLETVFRILDSDNSGRISIDEFKEGCKILKSHSKANMTPEAMEDLARSIDINKDGSIDLNEFLEAFRI 1991
            +MGC+  S+L KN     ++   + ++ + L   K+V+ IQK+YR Y+A+ EA+RK  W I+Q +EYS EQ+Q+ +       ++   +++      F+K  +     K++  + +   L+  ++G  +++P+T  ++ +L+  +   NN+  L    L ELL++ + +L+  PN+ E        ITICGD+HG   DL+ IF++N  P  SNPY+FNGDF+DRG  SVE+  +L    +  P  VFLNRGNHED  MN RYGF KE+  KY                                                  K+ S L   SD+  E +  EW QVL++LWSDP+P  GC+ N +RGGGCYFGPD+T QFLEK   +L+IRSHECK  G+++CH+D+VLT+FSASNYY+ GSN GAF  + KS   +I  + +++  +F+K+          EE ++R L ++I   R+ L+ +F   D D     SG+I    W   M+ ++ +DLPWR L+  L    P+  +     +  +      Q    KIS   EI  ++   +E +F +LDS  SG ++  EF E  +   +  +  +  E +  L ++ D+N DG ID  EFL+  RI
Sbjct:   69 VMGCKLSSNLFKNNTNDDMIACKSSNIVATL---KAVLLIQKYYRRYRAKCEAKRKMIWKIHQLVEYSNEQNQILMQKLLSITLHNNPERHFDVKCKFSKFNDILPPDKQAIPWADIDALDASHNGFKLKYPITSKIVRNLVEFYKSGNNK--LSNRDLIELLLRAQVVLRDLPNVYEISPV---SITICGDIHGNFDDLVTIFQKNCLPSTSNPYLFNGDFVDRGSKSVEVISVLLVCFLQNPNAVFLNRGNHEDHFMNSRYGFFKELNNKY--------------------------------------------------KFKSVLQYESDNMNECEINEWKQVLNLLWSDPRPLNGCKMNTYRGGGCYFGPDVTLQFLEKNFMKLIIRSHECKMNGWDYCHEDKVLTLFSASNYYELGSNYGAFAIIDKSANVRITQYKSQEGVDFRKN----------EEESVRCLMSEIWRKRNSLLKKFREFDIDKSDKYSGVISIGQWVTAMSTIMNMDLPWRQLKWYL---IPTSLVETDVPYLTMINNAEIQYTNKKISSLGEIDSRFDSNVEEMFHVLDSKYSGHLTFPEFAEFIQNT-TLGQNPLQDEELTQLWKNFDLNNDGWIDKEEFLKIARI 634