DNA topoisomerase

Overview
NameDNA topoisomerase
Smed IDSMED30014945
Length (bp)366
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA topoisomerase (SMED30014945) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA topoisomerase (SMED30014945) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014945

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30014945SMESG000081337.1 SmedASXL_018637SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of DNA topoisomerase vs. Ensembl Human
Match: TOP3A (DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992])

HSP 1 Score: 137.117 bits (344), Expect = 5.228e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   11 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. Ensembl Human
Match: TOP3A (DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992])

HSP 1 Score: 137.117 bits (344), Expect = 5.228e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   11 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. Ensembl Human
Match: TOP3A (DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992])

HSP 1 Score: 137.117 bits (344), Expect = 5.239e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Human
Match: TOP3A (DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992])

HSP 1 Score: 137.117 bits (344), Expect = 5.239e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Human
Match: TOP3A (DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992])

HSP 1 Score: 137.117 bits (344), Expect = 5.239e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Celegans
Match: top-3 (DNA topoisomerase 3 [Source:UniProtKB/Swiss-Prot;Acc:O61660])

HSP 1 Score: 131.339 bits (329), Expect = 1.479e-36
Identity = 62/118 (52.54%), Postives = 81/118 (68.64%), Query Frame = 2 
Query:   11 LNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            L VAEKND AK ++  LSNGTA+++EG+S +NKIY     L GQQT + +TSVSGHMMNF+F   MSNW+     ELF  PV  V T  MK ++ +L    +  ++L++WTDCDREGE
Sbjct:    5 LFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGHMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGE 122
[Close]
BLAST of DNA topoisomerase vs. Ensembl Celegans
Match: Y48C3A.14 (DNA topoisomerase [Source:UniProtKB/TrEMBL;Acc:H1UBJ8])

HSP 1 Score: 92.8189 bits (229), Expect = 6.278e-23
Identity = 43/120 (35.83%), Postives = 70/120 (58.33%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A +I+  LSNG A K++G +    + E+    NG+     +TS  GH+M+ +FP + +NW+ VDP EL+  P  ++  +    +   L +  K+ + L++W DCD+EGE
Sbjct:    4 TVLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHVMSLDFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Fly
Match: Top3alpha (gene:FBgn0040268 transcript:FBtr0081246)

HSP 1 Score: 150.214 bits (378), Expect = 6.845e-43
Identity = 67/121 (55.37%), Postives = 84/121 (69.42%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M  LNVAEKNDAAK I+G LSNG A ++EG SVYNK+++F+  + GQ   M+MTSVSGHMM   F +   NW+ VDP  LFD PV K    + + +K +LE  ++ C  LIIWTDCDREGE
Sbjct:   26 MKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGE 146
[Close]
BLAST of DNA topoisomerase vs. Ensembl Fly
Match: Top3beta (gene:FBgn0026015 transcript:FBtr0340028)

HSP 1 Score: 84.7297 bits (208), Expect = 4.918e-20
Identity = 44/121 (36.36%), Postives = 67/121 (55.37%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNL-NGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            ++L VAEK   A +++G LSNG    K G       +E+  N  N       MTSV GH+M+ +F  + + W  VDP +LF C   K  T+  +N++  L +  + C+ L++W DCD+EGE
Sbjct:    3 SVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Fly
Match: Top3beta (gene:FBgn0026015 transcript:FBtr0070930)

HSP 1 Score: 84.7297 bits (208), Expect = 4.918e-20
Identity = 44/121 (36.36%), Postives = 67/121 (55.37%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNL-NGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            ++L VAEK   A +++G LSNG    K G       +E+  N  N       MTSV GH+M+ +F  + + W  VDP +LF C   K  T+  +N++  L +  + C+ L++W DCD+EGE
Sbjct:    3 SVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Zebrafish
Match: top3a (DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-GENE-071212-2])

HSP 1 Score: 135.961 bits (341), Expect = 7.239e-38
Identity = 62/119 (52.10%), Postives = 79/119 (66.39%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SNG + ++EG SVYNKIYE++YNL GQ   + MTSVSGH++  EF      W    P  LFD  V K C +N   +K +LE  ++ C  LI+WTDCDREGE
Sbjct:   33 VLCVAEKNDAAKGIAEIMSNGRSRRREGCSVYNKIYEYEYNLFGQNVTVNMTSVSGHLLALEFKAPFQKWHSCSPVLLFDAEVEKYCPENFIPIKRTLEREVRQCQALIVWTDCDREGE 151
[Close]
BLAST of DNA topoisomerase vs. Ensembl Zebrafish
Match: top3b (DNA topoisomerase III beta [Source:ZFIN;Acc:ZDB-GENE-070705-37])

HSP 1 Score: 84.7297 bits (208), Expect = 7.327e-20
Identity = 44/121 (36.36%), Postives = 69/121 (57.02%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+  LS G+   ++G +    ++E+  +  GQ     MTSV GH+M+ +F  + +NW  VDP ELF   P  K   +   N+   L+   K C+ +++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIAKILSKGSCSTRKGLNGACSVHEYMGSFTGQNVRFKMTSVCGHVMSLDFIGKYNNWDKVDPAELFSKAPTEKKEANPKLNMVKFLQVEAKGCDYVVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Zebrafish
Match: top3b (DNA topoisomerase III beta [Source:ZFIN;Acc:ZDB-GENE-070705-37])

HSP 1 Score: 84.7297 bits (208), Expect = 7.327e-20
Identity = 44/121 (36.36%), Postives = 69/121 (57.02%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+  LS G+   ++G +    ++E+  +  GQ     MTSV GH+M+ +F  + +NW  VDP ELF   P  K   +   N+   L+   K C+ +++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIAKILSKGSCSTRKGLNGACSVHEYMGSFTGQNVRFKMTSVCGHVMSLDFIGKYNNWDKVDPAELFSKAPTEKKEANPKLNMVKFLQVEAKGCDYVVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Zebrafish
Match: BX005237.1 (DNA topoisomerase III beta [Source:NCBI gene;Acc:793414])

HSP 1 Score: 62.7734 bits (151), Expect = 2.678e-12
Identity = 31/80 (38.75%), Postives = 45/80 (56.25%), Query Frame = 2 
Query:  128 NLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +  GQ     MTSV GH+M+ +F  + +NW  VDP ELF   P  K   +   N+   L+   K C+ +++W DCD+EGE
Sbjct:    1 SFTGQNVRFKMTSVCGHVMSLDFIGKYNNWDKVDPAELFSKAPTEKKEANPKLNMVKFLQVEAKGCDYVVLWLDCDKEGE 80
[Close]
BLAST of DNA topoisomerase vs. Ensembl Xenopus
Match: cryba1 (crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956128])

HSP 1 Score: 133.65 bits (335), Expect = 7.190e-37
Identity = 58/119 (48.74%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SN    ++EG S +NKIYE++Y+L G+   ++MTSVSGH++  +F   M  W   +P  LF+  V K C D+  N+K +LE  ++ C  LIIWTDCDREGE
Sbjct:   41 VLCVAEKNDAAKGIADLMSNSRMRRREGFSKFNKIYEYEYHLFGKDVTVVMTSVSGHLLALDFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGE 159
[Close]
BLAST of DNA topoisomerase vs. Ensembl Xenopus
Match: cryba1 (crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956128])

HSP 1 Score: 133.65 bits (335), Expect = 7.541e-37
Identity = 58/119 (48.74%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SN    ++EG S +NKIYE++Y+L G+   ++MTSVSGH++  +F   M  W   +P  LF+  V K C D+  N+K +LE  ++ C  LIIWTDCDREGE
Sbjct:   41 VLCVAEKNDAAKGIADLMSNSRMRRREGFSKFNKIYEYEYHLFGKDVTVVMTSVSGHLLALDFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGE 159
[Close]
BLAST of DNA topoisomerase vs. Ensembl Xenopus
Match: cryba1 (crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956128])

HSP 1 Score: 133.265 bits (334), Expect = 1.055e-36
Identity = 58/119 (48.74%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SN    ++EG S +NKIYE++Y+L G+   ++MTSVSGH++  +F   M  W   +P  LF+  V K C D+  N+K +LE  ++ C  LIIWTDCDREGE
Sbjct:   41 VLCVAEKNDAAKGIADLMSNSRMRRREGFSKFNKIYEYEYHLFGKDVTVVMTSVSGHLLALDFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGE 159
[Close]
BLAST of DNA topoisomerase vs. Ensembl Xenopus
Match: cryba1 (crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956128])

HSP 1 Score: 133.265 bits (334), Expect = 1.068e-36
Identity = 58/119 (48.74%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SN    ++EG S +NKIYE++Y+L G+   ++MTSVSGH++  +F   M  W   +P  LF+  V K C D+  N+K +LE  ++ C  LIIWTDCDREGE
Sbjct:   31 VLCVAEKNDAAKGIADLMSNSRMRRREGFSKFNKIYEYEYHLFGKDVTVVMTSVSGHLLALDFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGE 149
[Close]
BLAST of DNA topoisomerase vs. Ensembl Xenopus
Match: cryba1 (crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956128])

HSP 1 Score: 98.9821 bits (245), Expect = 9.056e-25
Identity = 49/119 (41.18%), Postives = 69/119 (57.98%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +SN +  +++  S Y+               ++MTSVSGH++  +F   M  W   +P  LF+  V K C D+  N+K +LE  ++ C  LIIWTDCDREGE
Sbjct:   38 VLCVAEKNDAAKGIADLMSN-SRMRRQMFSRYD-------------VTVVMTSVSGHLLALDFQDHMKKWHSCNPVSLFEAEVQKYCPDDFVNIKRTLEREVRQCQALIIWTDCDREGE 142
[Close]
BLAST of DNA topoisomerase vs. Ensembl Mouse
Match: Top3a (topoisomerase (DNA) III alpha [Source:MGI Symbol;Acc:MGI:1197527])

HSP 1 Score: 136.732 bits (343), Expect = 2.653e-38
Identity = 61/119 (51.26%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   +KEG S +NKIYEF Y+L GQ   MIMTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE     C  L+IWTDCDREGE
Sbjct:   11 VLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. Ensembl Mouse
Match: Top3a (topoisomerase (DNA) III alpha [Source:MGI Symbol;Acc:MGI:1197527])

HSP 1 Score: 136.732 bits (343), Expect = 3.462e-38
Identity = 61/119 (51.26%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   +KEG S +NKIYEF Y+L GQ   MIMTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE     C  L+IWTDCDREGE
Sbjct:   11 VLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. Ensembl Mouse
Match: Top3a (topoisomerase (DNA) III alpha [Source:MGI Symbol;Acc:MGI:1197527])

HSP 1 Score: 136.732 bits (343), Expect = 3.796e-38
Identity = 61/119 (51.26%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   +KEG S +NKIYEF Y+L GQ   MIMTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE     C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Mouse
Match: Top3a (topoisomerase (DNA) III alpha [Source:MGI Symbol;Acc:MGI:1197527])

HSP 1 Score: 136.732 bits (343), Expect = 3.813e-38
Identity = 61/119 (51.26%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   +KEG S +NKIYEF Y+L GQ   MIMTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE     C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Mouse
Match: Top3b (topoisomerase (DNA) III beta [Source:MGI Symbol;Acc:MGI:1333803])

HSP 1 Score: 76.6406 bits (187), Expect = 9.852e-18
Identity = 41/121 (33.88%), Postives = 64/121 (52.89%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELF-DCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+  LS G     +G +    ++++     GQ     MTSV GH+M  +F  + + W  VDP ELF   P  K   +   N+   L+   + C+ +++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGTFAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. UniProt/SwissProt
Match: sp|Q9NG98|TOP3A_DROME (DNA topoisomerase 3-alpha OS=Drosophila melanogaster OX=7227 GN=Top3alpha PE=2 SV=2)

HSP 1 Score: 150.214 bits (378), Expect = 6.862e-42
Identity = 67/121 (55.37%), Postives = 84/121 (69.42%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M  LNVAEKNDAAK I+G LSNG A ++EG SVYNK+++F+  + GQ   M+MTSVSGHMM   F +   NW+ VDP  LFD PV K    + + +K +LE  ++ C  LIIWTDCDREGE
Sbjct:   26 MKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGE 146
[Close]
BLAST of DNA topoisomerase vs. UniProt/SwissProt
Match: sp|Q13472|TOP3A_HUMAN (DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 2.516e-37
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   ++EG S +NKIYEF Y+L GQ   M+MTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE   + C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. UniProt/SwissProt
Match: sp|O70157|TOP3A_MOUSE (DNA topoisomerase 3-alpha OS=Mus musculus OX=10090 GN=Top3a PE=2 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 2.667e-37
Identity = 61/119 (51.26%), Postives = 80/119 (67.23%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  LSNG   +KEG S +NKIYEF Y+L GQ   MIMTSVSGH++  +F ++   W+  +P  LF+  + K C +N  ++K +LE     C  L+IWTDCDREGE
Sbjct:   36 VLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. UniProt/SwissProt
Match: sp|O61660|TOP3_CAEEL (DNA topoisomerase 3 OS=Caenorhabditis elegans OX=6239 GN=top-3 PE=2 SV=1)

HSP 1 Score: 131.339 bits (329), Expect = 1.882e-35
Identity = 62/118 (52.54%), Postives = 81/118 (68.64%), Query Frame = 2 
Query:   11 LNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            L VAEKND AK ++  LSNGTA+++EG+S +NKIY     L GQQT + +TSVSGHMMNF+F   MSNW+     ELF  PV  V T  MK ++ +L    +  ++L++WTDCDREGE
Sbjct:    5 LFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGHMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGE 122
[Close]
BLAST of DNA topoisomerase vs. UniProt/SwissProt
Match: sp|Q9LVP1|TOP3A_ARATH (DNA topoisomerase 3-alpha OS=Arabidopsis thaliana OX=3702 GN=TOP3A PE=1 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 6.611e-35
Identity = 58/121 (47.93%), Postives = 80/121 (66.12%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +T+LNVAEK   AK+++G LS GT   +EG+S YNKI+EF Y +NGQ   M+MTSV GH+M  EF  R   W   DP +L+  PV K   ++ K++K +LE   +  + L++W DCDREGE
Sbjct:    9 VTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. TrEMBL
Match: A0A1B6ECA1 (DNA topoisomerase (Fragment) OS=Clastoptera arizonana OX=38151 GN=g.11036 PE=3 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 5.555e-46
Identity = 75/121 (61.98%), Postives = 89/121 (73.55%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M +LNVAEKND AK ++ FLS G + K+EG SVYNKIYEF+YN  G +  MIMTSVSGH++N EF     NWK  +P  LFD PVNK CT + + +K +LE  IKSCN LIIWTDCDREGE
Sbjct:   38 MKVLNVAEKNDVAKNLAFFLSGGNSRKREGFSVYNKIYEFEYNFQGTRRQMIMTSVSGHLLNNEFMGTYKNWKSCNPLSLFDAPVNKSCTQDYEPIKRTLEREIKSCNTLIIWTDCDREGE 158
[Close]
BLAST of DNA topoisomerase vs. TrEMBL
Match: A0A0L0CIM9 (DNA topoisomerase (Fragment) OS=Lucilia cuprina OX=7375 GN=FF38_12991 PE=3 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 7.754e-46
Identity = 73/121 (60.33%), Postives = 92/121 (76.03%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M  LNVAEKNDAAK I+G LSNGTA ++EG SVYNKIYEF+  + G+++ M+MTSVSGH++ FEF     NW  VDP+ LFD PV K C++N   +K +LE  ++SCN LI+WTDCDREGE
Sbjct:   26 MKYLNVAEKNDAAKTIAGQLSNGTARRREGLSVYNKIYEFEATVLGRKSKMVMTSVSGHLLTFEFLSSYRNWNNVDPQSLFDAPVRKACSENFAAIKRTLEREVRSCNGLIVWTDCDREGE 146
[Close]
BLAST of DNA topoisomerase vs. TrEMBL
Match: A0A182GUY7 (DNA topoisomerase OS=Aedes albopictus OX=7160 GN=RP20_CCG016201 PE=3 SV=1)

HSP 1 Score: 164.851 bits (416), Expect = 1.343e-44
Identity = 72/121 (59.50%), Postives = 90/121 (74.38%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M  LNVAEKNDAAK I+G LS G++H++EG S YNKIYEF Y++ GQQ  M+MTSVSGH++N+EF      W   +PE+LFD PV K CT+NM  +K +LE  +K C  L+IWTDCDREGE
Sbjct:    1 MKYLNVAEKNDAAKNIAGLLSRGSSHRREGYSPYNKIYEFNYSIRGQQVQMVMTSVSGHLLNYEFLPSFRGWNSCNPEQLFDAPVRKTCTENMDKIKQTLEREVKYCQTLVIWTDCDREGE 121
[Close]
BLAST of DNA topoisomerase vs. TrEMBL
Match: A0A0T6AY37 (DNA topoisomerase (Fragment) OS=Oryctes borbonicus OX=1629725 GN=AMK59_7330 PE=3 SV=1)

HSP 1 Score: 154.451 bits (389), Expect = 3.615e-44
Identity = 69/121 (57.02%), Postives = 89/121 (73.55%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M  LNVAEKNDAAK I+  LS+ +A+++EG S YNKIYEF   LNGQQT M+MTSVSGH++N+ FP    +W+  +P  LFD P+ KVC ++ + +K +LE  I+ C  LIIWTDCDREGE
Sbjct:    1 MKYLNVAEKNDAAKNIAAILSSRSANRREGLSNYNKIYEFDATLNGQQTRMVMTSVSGHLLNYAFPANFKSWQSCNPLVLFDAPITKVCPEDSQRIKKTLEREIRGCQALIIWTDCDREGE 121
[Close]
BLAST of DNA topoisomerase vs. TrEMBL
Match: A0A1B6FT43 (DNA topoisomerase (Fragment) OS=Cuerna arida OX=1464854 GN=g.338 PE=3 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 9.550e-44
Identity = 69/121 (57.02%), Postives = 86/121 (71.07%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M+ILNVAEKND AK +SG+LS G + ++EG S YNKIYEF   + GQQ  MIMTSVSGH++NFEF      W    P +LFD P+ K C  + + +K +LE  ++SCN LIIWTDCDREGE
Sbjct:   45 MSILNVAEKNDVAKHLSGYLSGGNSRRREGFSKYNKIYEFDCLVRGQQRKMIMTSVSGHLLNFEFEGNYQKWHSCRPIDLFDAPIKKFCPPDYEPIKRTLEREVRSCNTLIIWTDCDREGE 165
[Close]
BLAST of DNA topoisomerase vs. Ensembl Cavefish
Match: top3a (DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-GENE-071212-2])

HSP 1 Score: 136.732 bits (343), Expect = 3.331e-38
Identity = 63/119 (52.94%), Postives = 79/119 (66.39%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK I+  +S+G A ++EG SVYNKIYE++YNL GQ   + MTSVSGH++  EF      W   +P  LFD  V K C +N   +K +LE   + C  LIIWTDCDREGE
Sbjct:   34 VLCVAEKNDAAKGIAEIMSSGRARRREGLSVYNKIYEYEYNLFGQNVTVNMTSVSGHLLALEFKAHFQKWHSCNPVLLFDAEVEKYCPENYVQIKRTLEKEARQCQALIIWTDCDREGE 152
[Close]
BLAST of DNA topoisomerase vs. Ensembl Cavefish
Match: top3b (DNA topoisomerase III beta [Source:NCBI gene;Acc:103043516])

HSP 1 Score: 80.1073 bits (196), Expect = 1.928e-18
Identity = 41/121 (33.88%), Postives = 68/121 (56.20%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+  LS G+   ++G +    ++++  +  GQ     MTSV GH+M+ +F  + +NW  VDP EL    P  K   +   ++   L+   K C+ +++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIAKILSKGSCSSRKGLNGACSVHDYTGSFMGQSVRFKMTSVCGHVMSLDFTGKYNNWDKVDPAELLSKAPTEKKEANPKLSMVKFLQVEAKGCDYVVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Ensembl Cavefish
Match: top3a (DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-GENE-071212-2])

HSP 1 Score: 79.337 bits (194), Expect = 4.384e-18
Identity = 34/69 (49.28%), Postives = 41/69 (59.42%), Query Frame = 2 
Query:  158 MTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MTSVSGH++  EF      W   +P  LFD  V K C +N   +K +LE   + C  LIIWTDCDREGE
Sbjct:    1 MTSVSGHLLALEFKAHFQKWHSCNPVLLFDAEVEKYCPENYVQIKRTLEKEARQCQALIIWTDCDREGE 69
[Close]
BLAST of DNA topoisomerase vs. Ensembl Sea Lamprey
Match: top3a (DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-GENE-071212-2])

HSP 1 Score: 132.88 bits (333), Expect = 1.626e-37
Identity = 59/119 (49.58%), Postives = 83/119 (69.75%), Query Frame = 2 
Query:   11 LNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQT-DMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            L VAEKNDAAK I+  +S G   ++EG S +NKIYE+ Y+ +GQQ  +++MTSVSGH++  EF     NW+G  P +LFD  + K+C +++  +K +LE  ++ C  LIIWTDCDREGE
Sbjct:   36 LCVAEKNDAAKGIANIMSRGGFTRREGLSKFNKIYEYNYSFSGQQNVNVVMTSVSGHLLGLEFIAGFKNWRGCHPVDLFDAEIEKICLNDLVAIKRTLEREVRQCQALIIWTDCDREGE 154
[Close]
BLAST of DNA topoisomerase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006910.1 (pep scaffold:Pmarinus_7.0:GL489578:1765:6875:1 gene:ENSPMAG00000006247.1 transcript:ENSPMAT00000006910.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 66.6254 bits (161), Expect = 9.766e-15
Identity = 34/100 (34.00%), Postives = 53/100 (53.00%), Query Frame = 2 
Query:   68 GTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            G+   ++G +    ++E+     GQ     MTSV GH+M  +F  + +NW  VDP ELF   P  K   +   ++   L+   K C+ +++W DCDREGE
Sbjct:    1 GSMTSRKGLNGACSVHEYMGTFQGQSARFKMTSVCGHVMTLDFIGKYNNWDQVDPAELFSKAPTEKKEANPKLSMGKFLQIEGKGCDYVVLWLDCDREGE 100
[Close]
BLAST of DNA topoisomerase vs. Ensembl Yeast
Match: TOP3 (DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination [Source:SGD;Acc:S000004224])

HSP 1 Score: 95.5153 bits (236), Expect = 1.076e-24
Identity = 46/126 (36.51%), Postives = 74/126 (58.73%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYN-----LNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M +L VAEKN  AKA+S  L  G +  ++   +Y K Y+F ++      NG   ++ MTSV+GH+   +F      W     +ELFD P+N++  +N K + ++++   ++ + L+IWTDCDREGE
Sbjct:    1 MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGE 126
[Close]
BLAST of DNA topoisomerase vs. Ensembl Nematostella
Match: EDO40018 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S883])

HSP 1 Score: 130.568 bits (327), Expect = 2.068e-36
Identity = 60/121 (49.59%), Postives = 78/121 (64.46%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            M +LNVAEKNDAAK +S  +S G   ++EG+S +NKIYEF +N+      M+MTSVSGH+M+ EF I    W    P  LFD PV K   ++   +K +LE  ++    LIIWTDCDREGE
Sbjct:    1 MRVLNVAEKNDAAKELSRIMSRGQCTRREGQSRFNKIYEFNFNILNANARMVMTSVSGHLMSLEFAIAYRKWSSCSPLSLFDAPVVKNVGEDYLPIKKTLECEVRGSQALIIWTDCDREGE 121
[Close]
BLAST of DNA topoisomerase vs. Ensembl Nematostella
Match: EDO44262 (DNA topoisomerase [Source:UniProtKB/TrEMBL;Acc:A7RW77])

HSP 1 Score: 82.8037 bits (203), Expect = 9.717e-20
Identity = 44/121 (36.36%), Postives = 71/121 (58.68%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCP-VNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+ FLSNG  + ++G +    ++E+  +   +     MTSV GH+M+ +F  + +NW  VDP ELF    + K  T+ ++  K  L +  K  + L++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIAKFLSNGRMNSRKGLNGACSVHEYSGSFRNEPVKFKMTSVCGHVMSLDFHHKYNNWDAVDPLELFTATTLKKEATEKLQMPKF-LSHEAKGVDYLVLWLDCDKEGE 122
[Close]
BLAST of DNA topoisomerase vs. Ensembl Medaka
Match: top3a (DNA topoisomerase III alpha [Source:NCBI gene;Acc:101168371])

HSP 1 Score: 137.117 bits (344), Expect = 2.749e-38
Identity = 62/119 (52.10%), Postives = 79/119 (66.39%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK IS  +S+G A ++EG S +NKIYE++Y L GQ   + MTSVSGH++  EF      W   +P  LFD  V K C DNM  +K +LE  ++ C  L+IWTDCDREGE
Sbjct:   11 VLCVAEKNDAAKGISEIMSSGRARRREGMSKFNKIYEYEYFLFGQNVTVTMTSVSGHLLALEFKAPFQKWHSCNPVMLFDAEVEKYCPDNMIPIKRTLEKEVRQCQALVIWTDCDREGE 129
[Close]
BLAST of DNA topoisomerase vs. Ensembl Medaka
Match: top3a (DNA topoisomerase III alpha [Source:NCBI gene;Acc:101168371])

HSP 1 Score: 137.117 bits (344), Expect = 2.757e-38
Identity = 62/119 (52.10%), Postives = 79/119 (66.39%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK IS  +S+G A ++EG S +NKIYE++Y L GQ   + MTSVSGH++  EF      W   +P  LFD  V K C DNM  +K +LE  ++ C  L+IWTDCDREGE
Sbjct:   54 VLCVAEKNDAAKGISEIMSSGRARRREGMSKFNKIYEYEYFLFGQNVTVTMTSVSGHLLALEFKAPFQKWHSCNPVMLFDAEVEKYCPDNMIPIKRTLEKEVRQCQALVIWTDCDREGE 172
[Close]
BLAST of DNA topoisomerase vs. Ensembl Medaka
Match: top3a (DNA topoisomerase III alpha [Source:NCBI gene;Acc:101168371])

HSP 1 Score: 137.117 bits (344), Expect = 2.759e-38
Identity = 62/119 (52.10%), Postives = 79/119 (66.39%), Query Frame = 2 
Query:    8 ILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            +L VAEKNDAAK IS  +S+G A ++EG S +NKIYE++Y L GQ   + MTSVSGH++  EF      W   +P  LFD  V K C DNM  +K +LE  ++ C  L+IWTDCDREGE
Sbjct:   52 VLCVAEKNDAAKGISEIMSSGRARRREGMSKFNKIYEYEYFLFGQNVTVTMTSVSGHLLALEFKAPFQKWHSCNPVMLFDAEVEKYCPDNMIPIKRTLEKEVRQCQALVIWTDCDREGE 170
[Close]
BLAST of DNA topoisomerase vs. Ensembl Medaka
Match: top3a (DNA topoisomerase III alpha [Source:NCBI gene;Acc:101168371])

HSP 1 Score: 83.9593 bits (206), Expect = 1.079e-19
Identity = 35/69 (50.72%), Postives = 43/69 (62.32%), Query Frame = 2 
Query:  158 MTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MTSVSGH++  EF      W   +P  LFD  V K C DNM  +K +LE  ++ C  L+IWTDCDREGE
Sbjct:    1 MTSVSGHLLALEFKAPFQKWHSCNPVMLFDAEVEKYCPDNMIPIKRTLEKEVRQCQALVIWTDCDREGE 69
[Close]
BLAST of DNA topoisomerase vs. Ensembl Medaka
Match: top3b (DNA topoisomerase III beta [Source:NCBI gene;Acc:101167966])

HSP 1 Score: 83.5741 bits (205), Expect = 1.241e-19
Identity = 42/121 (34.71%), Postives = 68/121 (56.20%), Query Frame = 2 
Query:    5 TILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFD-CPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            T+L VAEK   A++I+  LS G+   ++G +    ++E+     GQ     MTSV GH+M+ +F  + +NW  VDP ELF   P  K   +   ++   L+   + C+ +++W DCD+EGE
Sbjct:    3 TVLMVAEKPSLAQSIARILSKGSCTSRKGLNGACSVHEYTGTFQGQSVRFKMTSVCGHVMSLDFIGKYNNWDKVDPAELFSKAPTEKKEANPKLSMVKFLQVEARGCDFVVLWLDCDKEGE 123
[Close]
BLAST of DNA topoisomerase vs. Planmine SMEST
Match: SMESG000081337.1 (SMESG000081337.1)

HSP 1 Score: 252.677 bits (644), Expect = 1.242e-79
Identity = 120/121 (99.17%), Postives = 120/121 (99.17%), Query Frame = 2 
Query:    2 MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MTILNVAEKNDAAKAISGFLSNGTA KKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE
Sbjct:    1 MTILNVAEKNDAAKAISGFLSNGTARKKEGKSVYNKIYEFKYNLNGQQTDMIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 121
[Close]
BLAST of DNA topoisomerase vs. Planmine SMEST
Match: SMESG000081353.1 (SMESG000081353.1)

HSP 1 Score: 98.9821 bits (245), Expect = 3.680e-25
Identity = 44/71 (61.97%), Postives = 51/71 (71.83%), Query Frame = 2 
Query:  152 MIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MIMTSVSGH M+F FP  + NWK V+P  LFD PV+K+C  NM  VK SL+ +   C  LIIWTDCDREGE
Sbjct:    1 MIMTSVSGHFMDFVFPEHLMNWKTVNPIALFDSPVDKICLKNMVGVKESLQKIATRCQRLIIWTDCDREGE 71
[Close]
BLAST of DNA topoisomerase vs. Planmine SMEST
Match: SMESG000081353.1 (SMESG000081353.1)

HSP 1 Score: 98.9821 bits (245), Expect = 4.361e-25
Identity = 44/71 (61.97%), Postives = 51/71 (71.83%), Query Frame = 2 
Query:  152 MIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MIMTSVSGH M+F FP  + NWK V+P  LFD PV+K+C  NM  VK SL+ +   C  LIIWTDCDREGE
Sbjct:    1 MIMTSVSGHFMDFVFPEHLMNWKTVNPIALFDSPVDKICLKNMVGVKESLQKIATRCQRLIIWTDCDREGE 71
[Close]
BLAST of DNA topoisomerase vs. Planmine SMEST
Match: SMESG000081353.1 (SMESG000081353.1)

HSP 1 Score: 95.5153 bits (236), Expect = 7.124e-24
Identity = 42/69 (60.87%), Postives = 49/69 (71.01%), Query Frame = 2 
Query:  158 MTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MTSVSGH M+F FP  + NWK V+P  LFD PV+K+C  NM  VK SL+ +   C  LIIWTDCDREGE
Sbjct:    1 MTSVSGHFMDFVFPEHLMNWKTVNPIALFDSPVDKICLKNMVGVKESLQKIATRCQRLIIWTDCDREGE 69
[Close]
BLAST of DNA topoisomerase vs. Planmine SMEST
Match: SMESG000081353.1 (SMESG000081353.1)

HSP 1 Score: 95.1301 bits (235), Expect = 8.836e-24
Identity = 42/69 (60.87%), Postives = 49/69 (71.01%), Query Frame = 2 
Query:  158 MTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASLENLIKSCNMLIIWTDCDREGE 364
            MTSVSGH M+F FP  + NWK V+P  LFD PV+K+C  NM  VK SL+ +   C  LIIWTDCDREGE
Sbjct:    1 MTSVSGHFMDFVFPEHLMNWKTVNPIALFDSPVDKICLKNMVGVKESLQKIATRCQRLIIWTDCDREGE 69
The following BLAST results are available for this feature:
BLAST of DNA topoisomerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TOP3A5.228e-3849.58DNA topoisomerase III alpha [Source:HGNC Symbol;Ac... [more]
TOP3A5.228e-3849.58DNA topoisomerase III alpha [Source:HGNC Symbol;Ac... [more]
TOP3A5.239e-3849.58DNA topoisomerase III alpha [Source:HGNC Symbol;Ac... [more]
TOP3A5.239e-3849.58DNA topoisomerase III alpha [Source:HGNC Symbol;Ac... [more]
TOP3A5.239e-3849.58DNA topoisomerase III alpha [Source:HGNC Symbol;Ac... [more]
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BLAST of DNA topoisomerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
top-31.479e-3652.54DNA topoisomerase 3 [Source:UniProtKB/Swiss-Prot;... [more]
Y48C3A.146.278e-2335.83DNA topoisomerase [Source:UniProtKB/TrEMBL;Acc:H1... [more]
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BLAST of DNA topoisomerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Top3alpha6.845e-4355.37gene:FBgn0040268 transcript:FBtr0081246[more]
Top3beta4.918e-2036.36gene:FBgn0026015 transcript:FBtr0340028[more]
Top3beta4.918e-2036.36gene:FBgn0026015 transcript:FBtr0070930[more]
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BLAST of DNA topoisomerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
top3a7.239e-3852.10DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-G... [more]
top3b7.327e-2036.36DNA topoisomerase III beta [Source:ZFIN;Acc:ZDB-GE... [more]
top3b7.327e-2036.36DNA topoisomerase III beta [Source:ZFIN;Acc:ZDB-GE... [more]
BX005237.12.678e-1238.75DNA topoisomerase III beta [Source:NCBI gene;Acc:7... [more]
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BLAST of DNA topoisomerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cryba17.190e-3748.74crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956... [more]
cryba17.541e-3748.74crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956... [more]
cryba11.055e-3648.74crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956... [more]
cryba11.068e-3648.74crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956... [more]
cryba19.056e-2541.18crystallin beta A1 [Source:Xenbase;Acc:XB-GENE-956... [more]
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BLAST of DNA topoisomerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Top3a2.653e-3851.26topoisomerase (DNA) III alpha [Source:MGI Symbol;A... [more]
Top3a3.462e-3851.26topoisomerase (DNA) III alpha [Source:MGI Symbol;A... [more]
Top3a3.796e-3851.26topoisomerase (DNA) III alpha [Source:MGI Symbol;A... [more]
Top3a3.813e-3851.26topoisomerase (DNA) III alpha [Source:MGI Symbol;A... [more]
Top3b9.852e-1833.88topoisomerase (DNA) III beta [Source:MGI Symbol;Ac... [more]
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BLAST of DNA topoisomerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9NG98|TOP3A_DROME6.862e-4255.37DNA topoisomerase 3-alpha OS=Drosophila melanogast... [more]
sp|Q13472|TOP3A_HUMAN2.516e-3749.58DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 ... [more]
sp|O70157|TOP3A_MOUSE2.667e-3751.26DNA topoisomerase 3-alpha OS=Mus musculus OX=10090... [more]
sp|O61660|TOP3_CAEEL1.882e-3552.54DNA topoisomerase 3 OS=Caenorhabditis elegans OX=6... [more]
sp|Q9LVP1|TOP3A_ARATH6.611e-3547.93DNA topoisomerase 3-alpha OS=Arabidopsis thaliana ... [more]
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BLAST of DNA topoisomerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B6ECA15.555e-4661.98DNA topoisomerase (Fragment) OS=Clastoptera arizon... [more]
A0A0L0CIM97.754e-4660.33DNA topoisomerase (Fragment) OS=Lucilia cuprina OX... [more]
A0A182GUY71.343e-4459.50DNA topoisomerase OS=Aedes albopictus OX=7160 GN=R... [more]
A0A0T6AY373.615e-4457.02DNA topoisomerase (Fragment) OS=Oryctes borbonicus... [more]
A0A1B6FT439.550e-4457.02DNA topoisomerase (Fragment) OS=Cuerna arida OX=14... [more]
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BLAST of DNA topoisomerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
top3a3.331e-3852.94DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-G... [more]
top3b1.928e-1833.88DNA topoisomerase III beta [Source:NCBI gene;Acc:1... [more]
top3a4.384e-1849.28DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of DNA topoisomerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
top3a1.626e-3749.58DNA topoisomerase III alpha [Source:ZFIN;Acc:ZDB-G... [more]
ENSPMAT00000006910.19.766e-1534.00pep scaffold:Pmarinus_7.0:GL489578:1765:6875:1 gen... [more]
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BLAST of DNA topoisomerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
TOP31.076e-2436.51DNA Topoisomerase III; conserved protein that func... [more]
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BLAST of DNA topoisomerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO400182.068e-3649.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO442629.717e-2036.36DNA topoisomerase [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of DNA topoisomerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
top3a2.749e-3852.10DNA topoisomerase III alpha [Source:NCBI gene;Acc:... [more]
top3a2.757e-3852.10DNA topoisomerase III alpha [Source:NCBI gene;Acc:... [more]
top3a2.759e-3852.10DNA topoisomerase III alpha [Source:NCBI gene;Acc:... [more]
top3a1.079e-1950.72DNA topoisomerase III alpha [Source:NCBI gene;Acc:... [more]
top3b1.241e-1934.71DNA topoisomerase III beta [Source:NCBI gene;Acc:1... [more]
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BLAST of DNA topoisomerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081337.11.242e-7999.17SMESG000081337.1[more]
SMESG000081353.13.680e-2561.97SMESG000081353.1[more]
SMESG000081353.14.361e-2561.97SMESG000081353.1[more]
SMESG000081353.17.124e-2460.87SMESG000081353.1[more]
SMESG000081353.18.836e-2460.87SMESG000081353.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014945 ID=SMED30014945|Name=DNA topoisomerase|organism=Schmidtea mediterranea sexual|type=transcript|length=366bp
TATGACTATTCTTAATGTTGCTGAAAAAAATGATGCAGCCAAAGCAATAT
CTGGATTTCTTTCAAATGGTACTGCTCACAAAAAAGAAGGAAAATCAGTT
TATAATAAGATCTACGAATTTAAATATAACTTAAATGGTCAACAAACTGA
TATGATTATGACATCAGTTTCTGGTCATATGATGAATTTCGAATTTCCTA
TTCGTATGAGCAATTGGAAAGGCGTTGATCCTGAAGAGTTGTTTGATTGT
CCGGTCAACAAAGTTTGCACTGATAATATGAAAAACGTTAAGGCATCATT
AGAAAATCTAATCAAATCATGCAATATGTTGATCATATGGACAGATTGTG
ATAGAGAAGGTGAAAA
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protein sequence of SMED30014945-orf-1

>SMED30014945-orf-1 ID=SMED30014945-orf-1|Name=SMED30014945-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=121bp
MTILNVAEKNDAAKAISGFLSNGTAHKKEGKSVYNKIYEFKYNLNGQQTD
MIMTSVSGHMMNFEFPIRMSNWKGVDPEELFDCPVNKVCTDNMKNVKASL
ENLIKSCNMLIIWTDCDREGE
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR000380Topo_IA
IPR034144TOPRIM_TopoIII
IPR006171TOPRIM_domain
IPR023405Topo_IA_core_domain
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0003916DNA topoisomerase activity
GO:0003917DNA topoisomerase type I activity
GO:0008270zinc ion binding
GO:0016853isomerase activity
Vocabulary: cellular component
TermDefinition
GO:0005694chromosome
Vocabulary: biological process
TermDefinition
GO:0006265DNA topological change
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006171TOPRIM domainSMARTSM00493toprim5coord: 2..121
e-value: 0.003
score: 26.3
IPR006171TOPRIM domainPFAMPF01751Toprimcoord: 5..121
e-value: 2.2E-13
score: 50.3
IPR006171TOPRIM domainPROSITEPS50880TOPRIMcoord: 2..121
score: 16.153
NoneNo IPR availableGENE3DG3DSA:3.40.50.140coord: 1..121
e-value: 3.6E-44
score: 152.8
NoneNo IPR availablePANTHERPTHR11390:SF21DNA TOPOISOMERASE 3-ALPHAcoord: 1..121
IPR000380DNA topoisomerase, type IAPANTHERPTHR11390PROKARYOTIC DNA TOPOISOMERASEcoord: 1..121
IPR034144DNA topoisomerase 3-like, TOPRIM domainCDDcd03362TOPRIM_TopoIA_TopoIIIcoord: 2..121
e-value: 6.7777E-39
score: 125.809
IPR023405DNA topoisomerase, type IA, core domainSUPERFAMILYSSF56712Prokaryotic type I DNA topoisomerasecoord: 3..121