N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Overview
NameN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Smed IDSMED30014853
Length (bp)1644
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (SMED30014853) t-SNE clustered cells

Violin plots show distribution of expression levels for N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (SMED30014853) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (SMED30014853) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (SMED30014853) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014853

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30014853 SmedASXL_068218SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30014853SMESG000000990.1 dd_Smed_v4_6408_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30014853SMESG000000990.1 dd_Smed_v4_6408_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30014853SMESG000000990.1 dd_Smed_v4_6408_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30014853SMESG000000990.1 dd_Smed_v4_6408_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30014853SMESG000000990.1 dd_Smed_v4_6408_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol;Acc:HGNC:21683])

HSP 1 Score: 296.59 bits (758), Expect = 4.516e-95
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol;Acc:HGNC:21683])

HSP 1 Score: 296.59 bits (758), Expect = 4.516e-95
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol;Acc:HGNC:21683])

HSP 1 Score: 296.59 bits (758), Expect = 4.516e-95
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol;Acc:HGNC:21683])

HSP 1 Score: 296.59 bits (758), Expect = 4.516e-95
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol;Acc:HGNC:21683])

HSP 1 Score: 296.59 bits (758), Expect = 4.516e-95
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Celegans
Match: nape-2 (N-Acyl Phosphatidyl Ethanolamine specific phospholipase D (NAPE-PLD) homolog [Source:UniProtKB/TrEMBL;Acc:Q8MXT4])

HSP 1 Score: 234.187 bits (596), Expect = 6.525e-72
Identity = 118/302 (39.07%), Postives = 188/302 (62.25%), Query Frame = 3 
Query:  186 KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDK----ANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYC-GAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVL-SEEHYMAPKEDLEKFVEN----KDIKFITINTGQTVEIKNK 1055
            K  D  +P++N     ++  SD     L  TWLGHA+VL++++G K + DPV+++R     + GP RYR  P  + +LP +D  V+SH+HYDH+D + +++++++   + W +P G K       IG+  +   + E+ W +  E  K+  +   I   P QHW  RGLFD    LW  +A IG + RF++ GDTG+C G FK+ GE  GPF+ AAIPIGAYEPR F+K QH+NPEEA+++H+ I+++ S+GIHWGT+ + S E+Y+ P++ L++ ++     K+  F+TI  G+  E  ++
Sbjct:   60 KILDVEIPVHNITADDFHSESD-----LFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNG-KTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ 355
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Celegans
Match: nape-2 (N-Acyl Phosphatidyl Ethanolamine specific phospholipase D (NAPE-PLD) homolog [Source:UniProtKB/TrEMBL;Acc:Q8MXT4])

HSP 1 Score: 234.572 bits (597), Expect = 7.258e-72
Identity = 118/302 (39.07%), Postives = 188/302 (62.25%), Query Frame = 3 
Query:  186 KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDK----ANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYC-GAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVL-SEEHYMAPKEDLEKFVEN----KDIKFITINTGQTVEIKNK 1055
            K  D  +P++N     ++  SD     L  TWLGHA+VL++++G K + DPV+++R     + GP RYR  P  + +LP +D  V+SH+HYDH+D + +++++++   + W +P G K       IG+  +   + E+ W +  E  K+  +   I   P QHW  RGLFD    LW  +A IG + RF++ GDTG+C G FK+ GE  GPF+ AAIPIGAYEPR F+K QH+NPEEA+++H+ I+++ S+GIHWGT+ + S E+Y+ P++ L++ ++     K+  F+TI  G+  E  ++
Sbjct:   81 KILDVEIPVHNITADDFHSESD-----LFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNG-KTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ 376
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Celegans
Match: nape-2 (N-Acyl Phosphatidyl Ethanolamine specific phospholipase D (NAPE-PLD) homolog [Source:UniProtKB/TrEMBL;Acc:Q8MXT4])

HSP 1 Score: 234.187 bits (596), Expect = 1.109e-71
Identity = 118/302 (39.07%), Postives = 188/302 (62.25%), Query Frame = 3 
Query:  186 KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDK----ANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYC-GAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVL-SEEHYMAPKEDLEKFVEN----KDIKFITINTGQTVEIKNK 1055
            K  D  +P++N     ++  SD     L  TWLGHA+VL++++G K + DPV+++R     + GP RYR  P  + +LP +D  V+SH+HYDH+D + +++++++   + W +P G K       IG+  +   + E+ W +  E  K+  +   I   P QHW  RGLFD    LW  +A IG + RF++ GDTG+C G FK+ GE  GPF+ AAIPIGAYEPR F+K QH+NPEEA+++H+ I+++ S+GIHWGT+ + S E+Y+ P++ L++ ++     K+  F+TI  G+  E  ++
Sbjct:   81 KILDVEIPVHNITADDFHSESD-----LFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNG-KTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ 376
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Celegans
Match: nape-1 (N-Acyl Phosphatidyl Ethanolamine specific phospholipase D (NAPE-PLD) homolog [Source:UniProtKB/TrEMBL;Acc:Q965X7])

HSP 1 Score: 223.016 bits (567), Expect = 1.079e-67
Identity = 127/344 (36.92%), Postives = 201/344 (58.43%), Query Frame = 3 
Query:   72 EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAA-KHLKGVKKA-DENLPIYNPYFIGYNETSDE--NNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANI----IGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGA-FKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVL-SEEHYMAPKEDLEKFVEN----KDIKFITINTGQTVEIKNK 1055
            E  K    WG  P     GL  + K +    + ++L   KK  D  LP++N        T+D+  + S L  TWLGHA+VL++++G K + DPV+++R     + GP RYR  P  + +LP +D  V+SH+HYDH+D + +++++N    + W +P G K  +    IG       + E+ W +  E  K+  + + I   P QH   RGL D    LW  +A IG + RF+F GDTG+C   FK+IGE  GPF+ AAIPIGAYEPR F+K  H+NP+EAV++H+ +++  S+GIHWGT+ + + E+Y+ P++ L++ ++     KD  F+T++ G+  E  ++
Sbjct:   27 ENPKSFTNWGGRP-----GLTNIFKLVLRETSHENLPSDKKVLDSTLPVHN-------ITADDFHSESGLFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKRITNLNPQIKWFVPLGLKKWMKNQGIG-ADGSNTVTELNWGESSEFVKNG-KTITIWCLPAQHSGQRGLSDHNHRLWSGWAVIGENRRFYFPGDTGFCDVEFKKIGEKLGPFDLAAIPIGAYEPRWFMKSHHINPDEAVEVHKLVRARNSIGIHWGTYPMGTTEYYLEPRDKLKELMDAREDLKDTSFVTVDMGEIWEASDR 356
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Zebrafish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:ZFIN;Acc:ZDB-GENE-030131-3856])

HSP 1 Score: 274.248 bits (700), Expect = 5.676e-87
Identity = 137/343 (39.94%), Postives = 205/343 (59.77%), Query Frame = 3 
Query:   57 TNCEKEGS--KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQTVEIKNKE 1058
              C +  S  ++ N W  W    Y+ + +L  ++       +   K+A D  LPI  PYFI   +   +  + ++ TWLGHA+VL+E++G  +L DP+FS R  P  ++GP RYR+ PC++ +LP +DAVVISH HYDH+D  ++  L+++    L W +P G    +    + C  + E+ WW    +   D   +    TP QHW  R   D  K+LWGS++ +G  +RF+F GDTGYC +FKEIG ++GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ S+ IHWGTF LS EHY+ P   L + + N  +    F T++ G++  I  K+
Sbjct:   23 VTCSRRDSQGRFVNPWSTWHFPSYTTVARL--FLTEKNNSKIPSAKEALDRELPIVQPYFIQNPDQCGQTGTSVRATWLGHATVLVEMEGLLVLTDPIFSQRASPVAFMGPKRYRDPPCTIEQLPRLDAVVISHTHYDHLDAASVTALNSRFGSALHWFVPLGLAEWM--QKTGCENVTELDWWVGSRIPGHD--NVSFFCTPAQHWCKRTPVDDNKTLWGSWSIVGSHSRFFFAGDTGYCASFKEIGRHFGPFDLAAIPIGAYVPRGIMKSQHVDPEEAVQIHIDVQAKASLAIHWGTFPLSYEHYLEPPARLREAMVNLGLNPDDFFTLHHGESRMINLKD 359
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Zebrafish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:ZFIN;Acc:ZDB-GENE-030131-3856])

HSP 1 Score: 274.248 bits (700), Expect = 5.676e-87
Identity = 137/343 (39.94%), Postives = 205/343 (59.77%), Query Frame = 3 
Query:   57 TNCEKEGS--KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQTVEIKNKE 1058
              C +  S  ++ N W  W    Y+ + +L  ++       +   K+A D  LPI  PYFI   +   +  + ++ TWLGHA+VL+E++G  +L DP+FS R  P  ++GP RYR+ PC++ +LP +DAVVISH HYDH+D  ++  L+++    L W +P G    +    + C  + E+ WW    +   D   +    TP QHW  R   D  K+LWGS++ +G  +RF+F GDTGYC +FKEIG ++GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ S+ IHWGTF LS EHY+ P   L + + N  +    F T++ G++  I  K+
Sbjct:   23 VTCSRRDSQGRFVNPWSTWHFPSYTTVARL--FLTEKNNSKIPSAKEALDRELPIVQPYFIQNPDQCGQTGTSVRATWLGHATVLVEMEGLLVLTDPIFSQRASPVAFMGPKRYRDPPCTIEQLPRLDAVVISHTHYDHLDAASVTALNSRFGSALHWFVPLGLAEWM--QKTGCENVTELDWWVGSRIPGHD--NVSFFCTPAQHWCKRTPVDDNKTLWGSWSIVGSHSRFFFAGDTGYCASFKEIGRHFGPFDLAAIPIGAYVPRGIMKSQHVDPEEAVQIHIDVQAKASLAIHWGTFPLSYEHYLEPPARLREAMVNLGLNPDDFFTLHHGESRMINLKD 359
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Zebrafish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:ZFIN;Acc:ZDB-GENE-030131-3856])

HSP 1 Score: 275.404 bits (703), Expect = 7.934e-87
Identity = 137/342 (40.06%), Postives = 205/342 (59.94%), Query Frame = 3 
Query:   60 NCEKEGS--KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQTVEIKNKE 1058
             C +  S  ++ N W  W    Y+ + +L  ++       +   K+A D  LPI  PYFI   +   +  + ++ TWLGHA+VL+E++G  +L DP+FS R  P  ++GP RYR+ PC++ +LP +DAVVISH HYDH+D  ++  L+++    L W +P G    +    + C  + E+ WW    +   D   +    TP QHW  R   D  K+LWGS++ +G  +RF+F GDTGYC +FKEIG ++GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ S+ IHWGTF LS EHY+ P   L + + N  +    F T++ G++  I  K+
Sbjct:   76 TCSRRDSQGRFVNPWSTWHFPSYTTVARL--FLTEKNNSKIPSAKEALDRELPIVQPYFIQNPDQCGQTGTSVRATWLGHATVLVEMEGLLVLTDPIFSQRASPVAFMGPKRYRDPPCTIEQLPRLDAVVISHTHYDHLDAASVTALNSRFGSALHWFVPLGLAEWM--QKTGCENVTELDWWVGSRIPGHD--NVSFFCTPAQHWCKRTPVDDNKTLWGSWSIVGSHSRFFFAGDTGYCASFKEIGRHFGPFDLAAIPIGAYVPRGIMKSQHVDPEEAVQIHIDVQAKASLAIHWGTFPLSYEHYLEPPARLREAMVNLGLNPDDFFTLHHGESRMINLKD 411
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Zebrafish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:ZFIN;Acc:ZDB-GENE-030131-3856])

HSP 1 Score: 275.404 bits (703), Expect = 7.934e-87
Identity = 137/342 (40.06%), Postives = 205/342 (59.94%), Query Frame = 3 
Query:   60 NCEKEGS--KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQTVEIKNKE 1058
             C +  S  ++ N W  W    Y+ + +L  ++       +   K+A D  LPI  PYFI   +   +  + ++ TWLGHA+VL+E++G  +L DP+FS R  P  ++GP RYR+ PC++ +LP +DAVVISH HYDH+D  ++  L+++    L W +P G    +    + C  + E+ WW    +   D   +    TP QHW  R   D  K+LWGS++ +G  +RF+F GDTGYC +FKEIG ++GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ S+ IHWGTF LS EHY+ P   L + + N  +    F T++ G++  I  K+
Sbjct:   76 TCSRRDSQGRFVNPWSTWHFPSYTTVARL--FLTEKNNSKIPSAKEALDRELPIVQPYFIQNPDQCGQTGTSVRATWLGHATVLVEMEGLLVLTDPIFSQRASPVAFMGPKRYRDPPCTIEQLPRLDAVVISHTHYDHLDAASVTALNSRFGSALHWFVPLGLAEWM--QKTGCENVTELDWWVGSRIPGHD--NVSFFCTPAQHWCKRTPVDDNKTLWGSWSIVGSHSRFFFAGDTGYCASFKEIGRHFGPFDLAAIPIGAYVPRGIMKSQHVDPEEAVQIHIDVQAKASLAIHWGTFPLSYEHYLEPPARLREAMVNLGLNPDDFFTLHHGESRMINLKD 411
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Xenopus
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:100494898])

HSP 1 Score: 286.574 bits (732), Expect = 5.471e-91
Identity = 147/347 (42.36%), Postives = 217/347 (62.54%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA----DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEI 1046
            ++VT   + +  ++ N W  W    +  +   +KW  +   K    V  +    D+ LP+  PYF+ Y + + +  + +++TWLGHASV++E+D    L DP+FS    P  + GP R+R  PCSV +LP IDAVVISHNHYDH+DY T+  L+ +    L W +P G    ++  + +CG   ++E+ WW+   +   DE  +  V+TP QHW  R   D  K LWGS++ +GPSNRF+F GDTGYC AF+EIG+ YGPF+ AAIPIGAYEPR F++ QHV+PEEAV+IH D++++ S+ IHWGTF L+ EH++ P     E LE++  N D  F  +N G+++ +
Sbjct:   70 EDVTKSRRHKNGRFVNPWPTWKTPSFWNI---LKW--AFTEKDNSSVPSSREELDKVLPVVKPYFVQYPDFAGKTENGIRVTWLGHASVMVEMDDVIFLTDPIFSQHASPLSFAGPKRFRGPPCSVEQLPKIDAVVISHNHYDHLDYNTVVGLNERFGTELRWFVPLG----LLNWMQSCGCDNVIELDWWEQNCVPGHDE--VTFVFTPCQHWCKRTPIDDNKVLWGSWSVLGPSNRFFFAGDTGYCAAFEEIGKRYGPFDIAAIPIGAYEPRWFMRSQHVDPEEAVRIHADVRAKKSIAIHWGTFALANEHFLDPPRKLSEALERYGLNID-DFFVLNHGESISL 404
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Xenopus
Match: NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:100494898])

HSP 1 Score: 286.96 bits (733), Expect = 7.384e-91
Identity = 138/296 (46.62%), Postives = 199/296 (67.23%), Query Frame = 3 
Query:  186 KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEI 1046
            ++ D+ LP+  PYF+ Y + + +  + +++TWLGHASV++E+D    L DP+FS    P  + GP R+R  PCSV +LP IDAVVISHNHYDH+DY T+  L+ +    L W +P G    ++  + +CG   ++E+ WW+   +   DE  +  V+TP QHW  R   D  K LWGS++ +GPSNRF+F GDTGYC AF+EIG+ YGPF+ AAIPIGAYEPR F++ QHV+PEEAV+IH D++++ S+ IHWGTF L+ EH++ P     E LE++  N D  F  +N G+++ +
Sbjct:  142 EELDKVLPVVKPYFVQYPDFAGKTENGIRVTWLGHASVMVEMDDVIFLTDPIFSQHASPLSFAGPKRFRGPPCSVEQLPKIDAVVISHNHYDHLDYNTVVGLNERFGTELRWFVPLG----LLNWMQSCGCDNVIELDWWEQNCVPGHDE--VTFVFTPCQHWCKRTPIDDNKVLWGSWSVLGPSNRFFFAGDTGYCAAFEEIGKRYGPFDIAAIPIGAYEPRWFMRSQHVDPEEAVRIHADVRAKKSIAIHWGTFALANEHFLDPPRKLSEALERYGLNID-DFFVLNHGESISL 430
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Mouse
Match: Napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:MGI Symbol;Acc:MGI:2140885])

HSP 1 Score: 288.5 bits (737), Expect = 4.188e-92
Identity = 141/327 (43.12%), Postives = 216/327 (66.06%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGV----KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVEN 998
            ++VT  +K +  ++ N W  W +     +P +++W+  +  K+  GV    ++ D+ LP+  PYF+   E +    + L++TWLGHA++++E+D    L DP+FS+R  P  Y+GP R+R  PC+++ELPTIDAV+ISHNHYDH+DY ++  L+ +    L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP +RF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QH +PE+AV+IH D++++ SV IHWGTF L+ EHY+ P   L + +E 
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---ISIPNVLRWL--IMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALER 367
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Mouse
Match: Napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:MGI Symbol;Acc:MGI:2140885])

HSP 1 Score: 288.5 bits (737), Expect = 4.188e-92
Identity = 141/327 (43.12%), Postives = 216/327 (66.06%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGV----KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVEN 998
            ++VT  +K +  ++ N W  W +     +P +++W+  +  K+  GV    ++ D+ LP+  PYF+   E +    + L++TWLGHA++++E+D    L DP+FS+R  P  Y+GP R+R  PC+++ELPTIDAV+ISHNHYDH+DY ++  L+ +    L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP +RF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QH +PE+AV+IH D++++ SV IHWGTF L+ EHY+ P   L + +E 
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---ISIPNVLRWL--IMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALER 367
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Match: sp|Q6IQ20|NAPEP_HUMAN (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Homo sapiens OX=9606 GN=NAPEPLD PE=1 SV=2)

HSP 1 Score: 296.59 bits (758), Expect = 2.169e-94
Identity = 149/350 (42.57%), Postives = 226/350 (64.57%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F  +  G++  + N +
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---PSIPNVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAE-DFFVLKHGESRYLNNDD 390
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Match: sp|Q5RCU3|NAPEP_PONAB (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Pongo abelii OX=9601 GN=NAPEPLD PE=2 SV=1)

HSP 1 Score: 295.434 bits (755), Expect = 5.888e-94
Identity = 147/336 (43.75%), Postives = 220/336 (65.48%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLK---GVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFI 1016
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H       ++ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D    L DP+FS+R  P  Y+GP R+R +PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAV+IH D++++ S+ IHWGTF L+ EHY+ P     E LE++  N +  F+
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---HSIPHVLRWLI-MEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVRETGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRRFMKYQHVDPEEAVRIHIDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAEDFFV 377
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Match: sp|Q58CN9|NAPEP_BOVIN (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Bos taurus OX=9913 GN=NAPEPLD PE=2 SV=1)

HSP 1 Score: 295.049 bits (754), Expect = 7.629e-94
Identity = 148/340 (43.53%), Postives = 220/340 (64.71%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCS-MAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDN-LCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQT 1037
            ++VT  +K +  ++ N W  W +     +P L++W+ +      +   K+ D+ LP+  PYFI   E +    + L++TWLGHA+V++E+D   +L DP+FS R  P   +GP R+R APC+V ELP IDAV++SHNHYDH+D  ++  L+ +  N L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QHV+PEEAVKIH D++++ SV IHWGTF L+ EHY+ P   L + +E   +K   F+ +  G++
Sbjct:   51 EDVTKSKKGKDGRFVNPWPTWKN---PSIPSLLRWVITERDHSSVPCSKELDKELPVLKPYFIDDPEEAGVRGAGLRVTWLGHATVMVEMDELILLTDPIFSARASPSQRMGPKRFRRAPCTVEELPRIDAVLVSHNHYDHLDCNSVIALNERFGNELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCSAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVKIHIDVQAKKSVAIHWGTFALANEHYLEPPAKLCEALEKYRLKTEDFLVLKHGES 381
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Match: sp|Q769K2|NAPEP_RAT (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Rattus norvegicus OX=10116 GN=Napepld PE=1 SV=1)

HSP 1 Score: 291.197 bits (744), Expect = 2.649e-92
Identity = 146/342 (42.69%), Postives = 222/342 (64.91%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKH--LKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQT 1037
            ++VT  +K +  ++ N W  W +     +P +++W+  M   H  + G K+  D+ LP+  PYFI   E +    + L++TWLGHA++++E+D   +L DP+FS+R  P  Y+GP R+R  PC+++ELP IDAV+ISHNHYDH+DY ++  L+ +    L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP NRF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QH +PE+AV+IH D++++ SV IHWGTF L+ EHY+ P   L + +E   +K   F  +  G++
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---VSIPNVLRWLI-MEKDHSSVPGSKEELDKELPVLKPYFISDPEEAGVREAGLRVTWLGHATLMVEMDELILLTDPMFSSRASPSQYMGPKRFRRPPCTISELPPIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDVQAKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLKSEDFFILKHGES 383
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Match: sp|Q8BH82|NAPEP_MOUSE (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Mus musculus OX=10090 GN=Napepld PE=1 SV=1)

HSP 1 Score: 288.5 bits (737), Expect = 2.929e-91
Identity = 141/327 (43.12%), Postives = 216/327 (66.06%), Query Frame = 3 
Query:   48 KNVTNCEK-EGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGV----KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCG--EIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVEN 998
            ++VT  +K +  ++ N W  W +     +P +++W+  +  K+  GV    ++ D+ LP+  PYF+   E +    + L++TWLGHA++++E+D    L DP+FS+R  P  Y+GP R+R  PC+++ELPTIDAV+ISHNHYDH+DY ++  L+ +    L W +P G    ++  +  CG   ++E+ WW+   +   D  K+  V+TP+QHW  R L D  K LWGS++ +GP +RF+F GDTGYC AF+EIG+ +GPF+ AAIPIGAYEPR F+K+QH +PE+AV+IH D++++ SV IHWGTF L+ EHY+ P   L + +E 
Sbjct:   52 EDVTKSKKGKDGRFVNPWPTWKN---ISIPNVLRWL--IMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLG----LLDWMQKCGCENVIELDWWEENCVPGHD--KVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALER 367
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Match: A0A564XWH5 (Lactamase_B domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS96 PE=4 SV=1)

HSP 1 Score: 306.99 bits (785), Expect = 4.153e-97
Identity = 151/286 (52.80%), Postives = 194/286 (67.83%), Query Frame = 3 
Query:  201 NLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVS--NCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQT 1037
            NLPI+ P F           S ++MTWLGH+SVL  IDG ++L DPVFS+RC    + GP RYR  PC +++LP IDAVVISHNHYDH+D  ++++L  +  NL W +P G +  I+  VS  N   + +  WW   E K   +  +K V+TPTQHWS R  FD F +LWGS+A IGP++R WFGGDTGYC  FKEIG + GPF+ AAIPIGAYEPR  L+ QHVNP EAV+IH++IK++ S+ IHWGTF LS+E YMAPK DL K ++  D+    F TI  GQ+
Sbjct:   22 NLPIHQPKFTSLGL----EKSGVRMTWLGHSSVLFLIDGVRVLTDPVFSDRCSASSFFGPLRYRPPPCKIDDLPYIDAVVISHNHYDHLDVNSVRELDKRFPNLYWFVPSGIRDFILATVSQANKDRVQDFLWW---EEKPIGDTGVKAVFTPTQHWSTRNFFDRFTTLWGSWALIGPNHRVWFGGDTGYCSVFKEIGHHLGPFDVAAIPIGAYEPRAVLRAQHVNPTEAVQIHKEIKAKYSIAIHWGTFPLSKESYMAPKNDLIKAIKEADLTEADFRTIFLGQS 300
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Match: A0A0R3SDP5 (Lactamase_B domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS2822 PE=4 SV=1)

HSP 1 Score: 308.145 bits (788), Expect = 4.437e-97
Identity = 151/286 (52.80%), Postives = 194/286 (67.83%), Query Frame = 3 
Query:  201 NLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVS--NCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQT 1037
            NLPI+ P F           S ++MTWLGH+SVL  IDG ++L DPVFS+RC    + GP RYR  PC +++LP IDAVVISHNHYDH+D  ++++L  +  NL W +P G +  I+  VS  N   + +  WW   E K   +  +K V+TPTQHWS R  FD F +LWGS+A IGP++R WFGGDTGYC  FKEIG + GPF+ AAIPIGAYEPR  L+ QHVNP EAV+IH++IK++ S+ IHWGTF LS+E YMAPK DL K ++  D+    F TI  GQ+
Sbjct:   57 NLPIHQPKFTSLGL----EKSGVRMTWLGHSSVLFLIDGVRVLTDPVFSDRCSASSFFGPLRYRPPPCKIDDLPYIDAVVISHNHYDHLDVNSVRELDKRFPNLYWFVPSGIRDFILATVSQANKDRVQDFLWW---EEKPIGDTGVKAVFTPTQHWSTRNFFDRFTTLWGSWALIGPNHRVWFGGDTGYCSVFKEIGHHLGPFDVAAIPIGAYEPRAVLRAQHVNPTEAVQIHKEIKAKYSIAIHWGTFPLSKESYMAPKNDLIKAIKEADLTEADFRTIFLGQS 335
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Match: A0A0R3W9K3 (Lactamase_B domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS7140 PE=4 SV=1)

HSP 1 Score: 305.834 bits (782), Expect = 3.912e-96
Identity = 148/286 (51.75%), Postives = 195/286 (68.18%), Query Frame = 3 
Query:  201 NLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMV--SNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQT 1037
            +LPIY P F       +     +++TWLGH+SVL+ +DG ++LCDPVFS RC    Y GP RYR  PC V +LP IDAV ISHNHYDH+D  +++ LS++     W +P   +  I+     +N   + +  WW   E +      +K+V+TPTQHWS R LFD+F SLWGS+A IGP +R WFGGDTGYCGAFKEIG + GPF+ AAIPIGAYEPR  LK QHVNP EAV+IH+DI++  S+GIHWGTF L++E +MAPK DLE+ ++   +   +F TI+ GQ+
Sbjct:   55 HLPIYRPKF-------EAQGDGVRLTWLGHSSVLVYVDGVRVLCDPVFSERCSASQYFGPRRYRPPPCKVEDLPPIDAVAISHNHYDHLDVNSVRDLSDRFPQAYWFVPSKCRDFILSTANQANGSRVQDFLWW---EERPIGGTGVKVVFTPTQHWSARNLFDSFASLWGSWALIGPKHRVWFGGDTGYCGAFKEIGRHLGPFDVAAIPIGAYEPRWVLKSQHVNPWEAVEIHKDIRARHSIGIHWGTFPLTQEAFMAPKTDLERALQTAGLHPSEFQTIHHGQS 330
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Match: A0A0R3X3E1 (Lactamase_B domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS7844 PE=4 SV=1)

HSP 1 Score: 300.827 bits (769), Expect = 3.037e-94
Identity = 158/333 (47.45%), Postives = 210/333 (63.06%), Query Frame = 3 
Query:   81 KYTNRWGLWPHGYYSG------LPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPY--IGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVS--NCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGL-FDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQT 1037
            ++ N W  W    +         P  + W  S +   L      D  LP+Y P F       + N+  +++TWLGH+SVL+ IDG ++LCDP+FS RC P+   G  RYR +PC V +LP IDAVVISHNHYDH+D  +++ LS++     W +P   +  I+  V+  N   + +  WW   E +   +  +K V+TPTQHWS R L FD+F +LWGS+A IGP +R WFGGDTGYC AFKEIG   GPF+ AAIPIGAYEPR  LK QHVNP EAV+IH+DI+++ SVGIHWGTF L+ E +MAPK DLEK V+   +   +F TI+ GQ+
Sbjct:   15 RFANPWSTWDDVRFRTAFALFFTPGDVDWCPSPSDPRL------DSQLPVYRPKF-------EVNSDEVRVTWLGHSSVLVYIDGIRVLCDPIFSERCSPFQHFGIRRYRPSPCKVEDLPHIDAVVISHNHYDHLDVNSVRDLSDRFPQAYWFVPSKCRGFILNTVNQPNESRVHDFLWW---EERPIGDTSVKAVFTPTQHWSARNLVFDSFATLWGSWALIGPKHRVWFGGDTGYCDAFKEIGGYLGPFDVAAIPIGAYEPRWVLKTQHVNPWEAVEIHKDIRAKHSVGIHWGTFPLTREAFMAPKMDLEKAVQAAGLSPFEFRTIHHGQS 331
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Match: A0A068X1Z1 (N acyl phosphatidylethanolamine hydrolyzing OS=Echinococcus granulosus OX=6210 GN=EgrG_000144800 PE=4 SV=1)

HSP 1 Score: 300.827 bits (769), Expect = 4.954e-94
Identity = 150/288 (52.08%), Postives = 198/288 (68.75%), Query Frame = 3 
Query:  201 NLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGE--IVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRG-LFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQTV 1040
            +LPIY P F       +     +++TWLGH+SVL+ +DG ++LCDPVFS RC    YIGP RYR  PC V +LP IDAVVISHNHYDH+D  +++ LS++     W +P G +  I+   +   E  + +  WW   E +   +  +K V+TPTQHWS R  LFD+F +LWGS+A IGP +R WFGGDTGYC AFKEIG + GPF+ AAIPIGAYEPR  LK QHVNP EAV+IH+DI+++ SVGIHWGTF L++E +MAPK  LEK ++   +   +F TI+ GQ++
Sbjct:   74 HLPIYRPKF-------EAKGDGVRLTWLGHSSVLVYVDGVRVLCDPVFSERCSASQYIGPRRYRPPPCKVEDLPPIDAVVISHNHYDHLDVNSVRGLSDRFPQAHWFVPSGCRDFILSTANEANESRVHDFLWW---EERPVGDTGVKAVFTPTQHWSARNFLFDSFATLWGSWALIGPKHRVWFGGDTGYCDAFKEIGGHLGPFDVAAIPIGAYEPRWVLKSQHVNPWEAVEIHKDIRAKYSVGIHWGTFPLTQESFMAPKTALEKALQTAGLHPSEFRTIHHGQSL 351
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Cavefish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:103040918])

HSP 1 Score: 274.633 bits (701), Expect = 7.831e-87
Identity = 143/347 (41.21%), Postives = 217/347 (62.54%), Query Frame = 3 
Query:   48 KNVTNCEKEGS-KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSN-CGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAP----KEDLEKFVENKDIKFITINTGQTVEIKNKE 1058
            + VT+  ++ S ++ N W  W    Y+ + +L  ++      ++   K+A D+ LP+  PYF+   E     +S L++TWLGHA+VLLE+DG  +L DP+FS R  P  ++GP RYR   C+V +LP +DAV+ISH HYDH+D +++  L+++    L W +P G    +  M  N C  ++E+ WW+   +   D+  +  V TP QHW  R   D  ++LWGS++ +GPS+RF+F GDTGYC  F+EIG+ +GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ SV IHWGTF L+ E+Y+ P    +E +     N D +F T+N G++  +   E
Sbjct:   51 EEVTHSSRDSSGRFINPWPTWQFPSYTTVLRL--FLTEKNHSNVPSSKQALDKELPVLEPYFVQNPEQCGRVSSSLRVTWLGHATVLLEMDGLVVLTDPIFSQRASPVPFLGPKRYRGPACTVAQLPRVDAVLISHTHYDHLDVDSVTALNSRFGAELRWFVPLG---LLDWMRKNGCENVIELDWWEENCVPGHDD--ITFVCTPAQHWCKRTPTDDNRALWGSWSVLGPSHRFFFAGDTGYCPVFQEIGKRFGPFDLAAIPIGAYLPRGIMKSQHVDPEEAVQIHIDVQAKNSVAIHWGTFALAYEYYLEPPVRVREAMVAHGLNPD-QFFTLNHGESRLLTQDE 389
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Cavefish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:103040918])

HSP 1 Score: 264.233 bits (674), Expect = 3.739e-82
Identity = 140/357 (39.22%), Postives = 215/357 (60.22%), Query Frame = 3 
Query:   48 KNVTNCEKEGS-KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSN-CGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISEL 1100
            + VT+  ++ S ++ N W  W    Y+ + +L  ++      ++   K+A D+ LP+  PYF+   E     +S L++TWLGHA+VLLE+DG  +L DP+FS R  P  ++GP RYR   C+V +LP +DAV+ISH HYDH+D +++  L+++    L W +P G    +  M  N C  ++E+ WW+   +   D+  +  V TP QHW  R   D  ++LWGS++ +GPS+RF+F GDTGYC  F+EIG+ +GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ SV IHWGTF L+ E      E +   V+      I  N+ Q   +K     ++     ++++L
Sbjct:   51 EEVTHSSRDSSGRFINPWPTWQFPSYTTVLRL--FLTEKNHSNVPSSKQALDKELPVLEPYFVQNPEQCGRVSSSLRVTWLGHATVLLEMDGLVVLTDPIFSQRASPVPFLGPKRYRGPACTVAQLPRVDAVLISHTHYDHLDVDSVTALNSRFGAELRWFVPLG---LLDWMRKNGCENVIELDWWEENCVPGHDD--ITFVCTPAQHWCKRTPTDDNRALWGSWSVLGPSHRFFFAGDTGYCPVFQEIGKRFGPFDLAAIPIGAYLPRGIMKSQHVDPEEAVQIHIDVQAKNSVAIHWGTFALAYETAFVVDE-VSTIVKEAVEGAIGENSYQQSRVKQWTNNVVEQCLSQLNKL 399
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Cavefish
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:103040918])

HSP 1 Score: 265.003 bits (676), Expect = 4.729e-82
Identity = 140/357 (39.22%), Postives = 215/357 (60.22%), Query Frame = 3 
Query:   48 KNVTNCEKEGS-KYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSN-CGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISEL 1100
            + VT+  ++ S ++ N W  W    Y+ + +L  ++      ++   K+A D+ LP+  PYF+   E     +S L++TWLGHA+VLLE+DG  +L DP+FS R  P  ++GP RYR   C+V +LP +DAV+ISH HYDH+D +++  L+++    L W +P G    +  M  N C  ++E+ WW+   +   D+  +  V TP QHW  R   D  ++LWGS++ +GPS+RF+F GDTGYC  F+EIG+ +GPF+ AAIPIGAY PR  +K QHV+PEEAV+IH D++++ SV IHWGTF L+ E      E +   V+      I  N+ Q   +K     ++     ++++L
Sbjct:   51 EEVTHSSRDSSGRFINPWPTWQFPSYTTVLRL--FLTEKNHSNVPSSKQALDKELPVLEPYFVQNPEQCGRVSSSLRVTWLGHATVLLEMDGLVVLTDPIFSQRASPVPFLGPKRYRGPACTVAQLPRVDAVLISHTHYDHLDVDSVTALNSRFGAELRWFVPLG---LLDWMRKNGCENVIELDWWEENCVPGHDD--ITFVCTPAQHWCKRTPTDDNRALWGSWSVLGPSHRFFFAGDTGYCPVFQEIGKRFGPFDLAAIPIGAYLPRGIMKSQHVDPEEAVQIHIDVQAKNSVAIHWGTFALAYETAFVVDE-VSTIVKEAVEGAIGENSYQQSRVKQWTNNVVEQCLSQLNKL 399
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Sea Lamprey
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:ZFIN;Acc:ZDB-GENE-030131-3856])

HSP 1 Score: 254.988 bits (650), Expect = 6.067e-81
Identity = 139/336 (41.37%), Postives = 193/336 (57.44%), Query Frame = 3 
Query:   81 KYTNRWGLW--PHGYYSGLPKLIKWMCSMAAKHLKGVKKADE---NLPIYNPYFI-GYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPT-IDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSN--CGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAF---IGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVE---NKDIKFITINTGQT 1037
            ++ N W  W  P   ++     +KWM  +  K    V  A+E    LP++ PYF+ G   +       +++TWLGHA VL+E++GF  L DPVFS R  P  + GP RYR  PC+V +LP  +DAV+ISHNHYDH+D+ ++ QL+ +       +P G    + G + N  C  + E+ WW   E        + + +TP QHW  RG FD  K LWGS+     +G   RF+F GDTGYC  F++IG  YGPF  AAIPIGAY P  F+  QHV+PE AVKIH D+++  SVGIHWGTF L+ E Y+ P + L + +    +K   F  +  G+T
Sbjct:    1 RFVNPWSTWKTPDKKHA-----LKWM--LTEKDFSKVPAAEELQRTLPVHKPYFVEGAGGSGGSPPESVRVTWLGHACVLVELEGFSFLTDPVFSERASPVGFAGPRRYRPVPCTVAQLPEGLDAVLISHNHYDHLDHNSVVQLNRRYGTRLSFVPLG----LAGWMQNTGCENVQELDWWS--ERSAGLRSNITVAFTPAQHWCKRGAFDDNKVLWGSWCVRCVLGTDARFYFAGDTGYCDVFQQIGRRYGPFTLAAIPIGAYAPSWFMSSQHVDPEAAVKIHVDVRAGYSVGIHWGTFSLANEFYLEPPQKLAEALSAGGHKPDVFFVLQHGET 323
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Yeast
Match: FMP30 (Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D [Source:SGD;Acc:S000006024])

HSP 1 Score: 173.711 bits (439), Expect = 9.320e-49
Identity = 97/245 (39.59%), Postives = 141/245 (57.55%), Query Frame = 3 
Query:  276 TWLGHASVLLEIDGFKILCDPVFSN-RCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSN-CGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWF-GGDTGYC-GAFKEIGENYGP-FNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVE 995
            TWLG +      +G +IL DP+FS+      +GP R    P  + E+P  D +++SHNH DH+D E+++  S K D+  W++P+G K+    M SN C  ++E+ WW+  ++KK++E    I  TP  HWS R L D  KSLW S+      N   F  GDTGY    F  I E +G     A +P G Y P    K +H+NP+E +KI +D+++   +G+HWGTFVLS E+++ PKE LE   E
Sbjct:  209 TWLGQSCNYTVYNGLRILTDPLFSDFLIHKTLGPKRITQMPSQITEVPKPDIILVSHNHPDHLDLESLEYWSGK-DSPLWIVPKGMKSY---MTSNGCDNVLELSWWETLQVKKNNE-IYHISATPAMHWSGRSLLDTNKSLWCSFLLTHHGNPILFHAGDTGYVKDLFVRIKERFGKGCKLALLPCGQYCPEWHQKPRHINPQEVLKIMKDLEARNVLGVHWGTFVLSGEYFLEPKEKLEMLAE 448
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Nematostella
Match: EDO39507 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Z0])

HSP 1 Score: 273.092 bits (697), Expect = 4.019e-88
Identity = 134/270 (49.63%), Postives = 182/270 (67.41%), Query Frame = 3 
Query:  261 SHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQL-SNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWD-YFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQTVEIK 1049
            S L++TWLGHA +L+++ G  IL DP  +   G    +   RYR  PC VNELP IDAV ISHNHYDH+DY T+QQL ++   N+ W +P G    +    S C  +VE++WWD +   K  D  ++K ++TP+QHWS R L D  KSLWGS++ +G + RF+F GDTGY   F+EIGE +GPF+ AAIPIGAY+PR FL FQHV+P  AV+IH+D+KS++S+GIHWGTF+L  EHY+ P +DL   ++   +    FI +  G+T EI 
Sbjct:   21 SALQVTWLGHAMLLVQLQGLNILTDPHLNEFAGLTRTLSAKRYRPPPCRVNELPEIDAVCISHNHYDHLDYNTVQQLNAHCGSNIYWYVPMGLGDWM--RRSGCHNVVELEWWDEHIHPKHRDRERVKFIFTPSQHWSRRTLTDENKSLWGSWSVVGSNKRFFFAGDTGYNKVFQEIGEMFGPFDVAAIPIGAYKPRWFLSFQHVDPAGAVQIHQDVKSKLSIGIHWGTFLLGHEHYLDPPKDLATSLQANSLSPASFIVLQHGETKEIS 288
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Nematostella
Match: EDO39506 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Y8])

HSP 1 Score: 270.396 bits (690), Expect = 4.311e-86
Identity = 133/329 (40.43%), Postives = 204/329 (62.01%), Query Frame = 3 
Query:  105 WPHGYYSGLPKLIKWMCSMAAKHLKGV------------KKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDI---KFITINTGQT 1037
            W      G   ++KW+  +    L GV            ++ +  LP+  P F       +     L++TW+GHA+ L++++G  IL DPVF++ CG    +G  R+R  PC++++LP IDAV+ISHNHYDH+DY T+ +L+ K  +++ W +P G    I      C  + EM+WWD      S    +  ++TPTQHW  R   D  K+LWGS+  IGP +R +FGGDTGYC  FK IG+ YGPF+ AAIPIGAY PR F++FQHV+P++AV+IH+D++++ S+ +HWGTF L+ EHY++P ++L++ ++++ I    FI +  G+T
Sbjct:   26 WADKTRMGFGSVLKWV--ITETDLSGVGGTWREGWKFKEEELNRTLPVLEPNF---EAIKNPPVDQLQVTWIGHATCLVQMNGLNILTDPVFNDYCGMNRLVGVKRFRPVPCTIDQLPQIDAVIISHNHYDHLDYTTVLELNRKFPESIHWYVPMGQGDWIKS--CGCQNVKEMEWWDQSTHPTSKGNDVAFIFTPTQHWCKRAATDDNKALWGSWTIIGPRHRVFFGGDTGYCDVFKTIGKKYGPFDLAAIPIGAYHPRWFMQFQHVDPQQAVQIHKDLQAKTSMAVHWGTFALAYEHYLSPPKELKEAMKSEGIPQSDFIIMKHGET 347
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Nematostella
Match: EDO39508 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Z1])

HSP 1 Score: 252.292 bits (643), Expect = 1.924e-80
Identity = 123/235 (52.34%), Postives = 163/235 (69.36%), Query Frame = 3 
Query:  261 SHLKMTWLGHASVLLEIDGFKILCDPVFSNRCG--PYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQL-SNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWD-YFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEE 953
            S L++TWLGHA +L+++ G  IL DP  +   G    +   RYR  PC VNELP IDAV ISHNHYDH+DY T+QQL ++   N+ W +P G    +    S C  +VE++WWD +   K  D  ++K ++TP+QHWS R L D  KSLWGS++ +G + RF+F GDTGY   F+EIGE +GPF+ AAIPIGAY+PR FL FQHV+P  AV+IH+D+KS +S+GIHWGTF+L  E
Sbjct:   21 SALQVTWLGHAMLLVQLQGLNILTDPHLNEFAGLTRTLSAKRYRPPPCRVNELPEIDAVCISHNHYDHLDYNTVQQLNAHCGSNIYWYVPMGLGDWM--RRSGCHNVVELEWWDEHIHPKHRDRERVKFIFTPSQHWSRRTLTDENKSLWGSWSVVGSNKRFFFAGDTGYNKVFQEIGEMFGPFDVAAIPIGAYKPRWFLSFQHVDPAGAVQIHQDVKSILSIGIHWGTFLLGHE 253
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Medaka
Match: napepld (N-acyl phosphatidylethanolamine phospholipase D [Source:NCBI gene;Acc:101162968])

HSP 1 Score: 278.87 bits (712), Expect = 1.300e-88
Identity = 142/340 (41.76%), Postives = 214/340 (62.94%), Query Frame = 3 
Query:   60 NCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKA-DENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGP--YIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNK-QDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIK---FITINTGQTVEIKNKE 1058
            + + +  ++ N W  W    +S L + +          +   K+A D  LP+  PYF+   + SD +   +++TWLGHA+VL+E+DG  IL DPVFS R  P  ++GP RYR  PC+V +LP IDAVVISH+HYDH+D  ++  L+ +   +L W +P G    +    + C  ++E+ WW+   +   D+  +  V TP+QHWS R  +D  K+LW S++ +GP +RF+F GDTGYC +F+EIG  +GPF+ AAIPIGAY+PR+ ++ QHV+PEEAV+IH+D++++ SV IHWGTF L+ E Y+ P   L + +E K +K   F T+N G++  I   E
Sbjct:   51 SAQDKHGRWINPWPTWRFPSHSMLFRFL--FLDKNHSDVPTSKEALDCALPVMEPYFVQNPQPSDSHPG-MRVTWLGHATVLVEMDGLTILTDPVFSQRASPLQFMGPKRYRGPPCTVEQLPRIDAVVISHSHYDHLDVGSVASLNARFGGDLRWFVPLGLMDWLAK--TGCENVIELDWWEENCVPGHDD--VTFVCTPSQHWSKRTPWDDNKTLWSSWSVLGPDHRFFFAGDTGYCSSFQEIGRRFGPFDLAAIPIGAYKPRDVMQGQHVDPEEAVEIHQDVQAKRSVAIHWGTFALANEFYLEPPVLLREALERKGLKPESFFTLNHGESRLIAADE 383
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Planmine SMEST
Match: SMESG000000990.1 (SMESG000000990.1)

HSP 1 Score: 765.377 bits (1975), Expect = 0.000e+0
Identity = 367/367 (100.00%), Postives = 367/367 (100.00%), Query Frame = 3 
Query:   24 MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELESFVGCFK 1124
            MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELESFVGCFK
Sbjct:    1 MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELESFVGCFK 367
[Close]
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Planmine SMEST
Match: SMESG000000990.1 (SMESG000000990.1)

HSP 1 Score: 752.666 bits (1942), Expect = 0.000e+0
Identity = 360/360 (100.00%), Postives = 360/360 (100.00%), Query Frame = 3 
Query:   24 MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELE 1103
            MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELE
Sbjct:    1 MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKHLKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFKILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYETIQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDERKLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFKEIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGIHWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIPTTTKEISELE 360
The following BLAST results are available for this feature:
BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NAPEPLD4.516e-9542.57N-acyl phosphatidylethanolamine phospholipase D [S... [more]
NAPEPLD4.516e-9542.57N-acyl phosphatidylethanolamine phospholipase D [S... [more]
NAPEPLD4.516e-9542.57N-acyl phosphatidylethanolamine phospholipase D [S... [more]
NAPEPLD4.516e-9542.57N-acyl phosphatidylethanolamine phospholipase D [S... [more]
NAPEPLD4.516e-9542.57N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
nape-26.525e-7239.07N-Acyl Phosphatidyl Ethanolamine specific phosphol... [more]
nape-27.258e-7239.07N-Acyl Phosphatidyl Ethanolamine specific phosphol... [more]
nape-21.109e-7139.07N-Acyl Phosphatidyl Ethanolamine specific phosphol... [more]
nape-11.079e-6736.92N-Acyl Phosphatidyl Ethanolamine specific phosphol... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
napepld5.676e-8739.94N-acyl phosphatidylethanolamine phospholipase D [S... [more]
napepld5.676e-8739.94N-acyl phosphatidylethanolamine phospholipase D [S... [more]
napepld7.934e-8740.06N-acyl phosphatidylethanolamine phospholipase D [S... [more]
napepld7.934e-8740.06N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
NAPEPLD5.471e-9142.36N-acyl phosphatidylethanolamine phospholipase D [S... [more]
NAPEPLD7.384e-9146.62N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Napepld4.188e-9243.12N-acyl phosphatidylethanolamine phospholipase D [S... [more]
Napepld4.188e-9243.12N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6IQ20|NAPEP_HUMAN2.169e-9442.57N-acyl-phosphatidylethanolamine-hydrolyzing phosph... [more]
sp|Q5RCU3|NAPEP_PONAB5.888e-9443.75N-acyl-phosphatidylethanolamine-hydrolyzing phosph... [more]
sp|Q58CN9|NAPEP_BOVIN7.629e-9443.53N-acyl-phosphatidylethanolamine-hydrolyzing phosph... [more]
sp|Q769K2|NAPEP_RAT2.649e-9242.69N-acyl-phosphatidylethanolamine-hydrolyzing phosph... [more]
sp|Q8BH82|NAPEP_MOUSE2.929e-9143.12N-acyl-phosphatidylethanolamine-hydrolyzing phosph... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A564XWH54.153e-9752.80Lactamase_B domain-containing protein OS=Hymenolep... [more]
A0A0R3SDP54.437e-9752.80Lactamase_B domain-containing protein OS=Hymenolep... [more]
A0A0R3W9K33.912e-9651.75Lactamase_B domain-containing protein OS=Taenia as... [more]
A0A0R3X3E13.037e-9447.45Lactamase_B domain-containing protein OS=Hydatigen... [more]
A0A068X1Z14.954e-9452.08N acyl phosphatidylethanolamine hydrolyzing OS=Ech... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
napepld7.831e-8741.21N-acyl phosphatidylethanolamine phospholipase D [S... [more]
napepld3.739e-8239.22N-acyl phosphatidylethanolamine phospholipase D [S... [more]
napepld4.729e-8239.22N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
napepld6.067e-8141.37N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
FMP309.320e-4939.59Protein with a role in maintaining mitochondrial m... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO395074.019e-8849.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO395064.311e-8640.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO395081.924e-8052.34Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
napepld1.300e-8841.76N-acyl phosphatidylethanolamine phospholipase D [S... [more]
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BLAST of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000000990.10.000e+0100.00SMESG000000990.1[more]
SMESG000000990.10.000e+0100.00SMESG000000990.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014853 ID=SMED30014853|Name=N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D|organism=Schmidtea mediterranea sexual|type=transcript|length=1644bp
TATATGATAACGCTTTTATTTAAATGGCTAAAAGAGATGCTGAATGCAAA
AATGTAACTAATTGTGAAAAAGAAGGATCAAAATATACTAATAGATGGGG
TTTGTGGCCTCATGGATATTATTCTGGGTTGCCCAAATTAATAAAGTGGA
TGTGTTCTATGGCCGCGAAACATCTTAAAGGTGTTAAGAAAGCGGATGAA
AACTTACCAATTTACAATCCTTATTTTATTGGATATAATGAAACTAGTGA
TGAAAATAATTCCCATTTAAAAATGACATGGCTTGGTCATGCTTCTGTTT
TATTAGAAATTGACGGATTTAAAATTTTGTGTGATCCTGTATTCAGCAAT
CGATGTGGTCCATATATAGGACCTGCTCGGTATCGAAATGCTCCTTGCAG
TGTAAATGAATTACCTACAATTGATGCTGTTGTAATTTCTCATAACCATT
ATGACCACATGGACTATGAAACTATACAACAGCTGAGTAATAAACAAGAT
AATTTATGTTGGTTAATACCCGAAGGGGATAAAGCAAACATAATTGGAAT
GGTGAGTAATTGTGGGGAAATAGTCGAGATGAAATGGTGGGATTATTTCG
AGCTTAAAAAATCAGATGAGCGCAAGTTGAAGATTGTCTATACTCCAACT
CAGCATTGGTCAAATCGAGGTTTATTTGATGCATTCAAGAGTCTATGGGG
TAGTTATGCGTTTATTGGTCCAAGTAATCGTTTCTGGTTTGGTGGTGATA
CTGGCTATTGTGGTGCATTTAAAGAGATAGGTGAAAACTACGGACCATTT
AATGGTGCGGCTATTCCAATAGGAGCCTATGAGCCAAGAGAATTTTTGAA
ATTCCAGCACGTAAATCCTGAGGAAGCAGTGAAAATCCATGAAGATATTA
AATCAGAAATATCAGTTGGTATTCACTGGGGTACATTTGTTCTTTCAGAA
GAACATTATATGGCACCTAAAGAAGATTTGGAAAAATTTGTTGAAAATAA
AGATATAAAATTTATTACAATAAATACCGGACAAACTGTGGAAATAAAAA
ATAAAGAATACACTATTATACCAACAACTACTAAAGAAATTTCAGAATTA
GAATCTTTCGTCGGGTGTTTCAAAAGATTAACTGTCCGCACACCGAAAAC
CCCTGTATAACCTTGAAAATTTGCCATTTTCTGGTCAAAAGGTCGATCAA
CTCTGACTAGTTTTAATCAGTAATGCAATATTCTTCGGTAGTTACGGTAA
CATTCACTTCATCCACCGTATCATTTGATATATGATCGTTTTTTAATACC
ATGTTTCAATGTTTCCCAAACTTTCTATTCATGCGTACCCTTTTCAAATA
TTTTTTATCACTTTGTATCCATAAGTAGAACATTTCTAGGAAGCACTATT
ATATATTATCTCTTACTTGTGACATTAGTGAGAGTTGTCTAAATTTAGGA
TTAAAAGTTTGATCTTATTTAAGGATCAATGTTAATGTAAAAATTTTTTT
GATTAATTATTTTGTTGAAAATTCTAGATGGGCCAAGAAGCTTCAAGTGA
AAATTAAGATAATTTATTTAACAAATTTTCCACAATATTTTAATGTTATT
TTATGTATTCAATTTTTAGAATAAAGTTTTACTTTATATAAAAA
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protein sequence of SMED30014853-orf-1

>SMED30014853-orf-1 ID=SMED30014853-orf-1|Name=SMED30014853-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=379bp
MAKRDAECKNVTNCEKEGSKYTNRWGLWPHGYYSGLPKLIKWMCSMAAKH
LKGVKKADENLPIYNPYFIGYNETSDENNSHLKMTWLGHASVLLEIDGFK
ILCDPVFSNRCGPYIGPARYRNAPCSVNELPTIDAVVISHNHYDHMDYET
IQQLSNKQDNLCWLIPEGDKANIIGMVSNCGEIVEMKWWDYFELKKSDER
KLKIVYTPTQHWSNRGLFDAFKSLWGSYAFIGPSNRFWFGGDTGYCGAFK
EIGENYGPFNGAAIPIGAYEPREFLKFQHVNPEEAVKIHEDIKSEISVGI
HWGTFVLSEEHYMAPKEDLEKFVENKDIKFITINTGQTVEIKNKEYTIIP
TTTKEISELESFVGCFKRLTVRTPKTPV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0000139Golgi membrane
GO:0005634nucleus
GO:0005635nuclear envelope
GO:0005654nucleoplasm
GO:0005768endosome
GO:0005769early endosome
GO:0005794Golgi apparatus
GO:0031901early endosome membrane
GO:0005829cytosol
GO:0016020membrane
GO:0042622photoreceptor outer segment membrane
GO:0043227membrane-bounded organelle
GO:0070062extracellular exosome
Vocabulary: biological process
TermDefinition
GO:0001659temperature homeostasis
GO:0048874homeostasis of number of cells in a free-living population
GO:0050729positive regulation of inflammatory response
GO:0070292N-acylphosphatidylethanolamine metabolic process
GO:0090336positive regulation of brown fat cell differentiation
GO:0001523retinoid metabolic process
GO:0006629lipid metabolic process
GO:0006644phospholipid metabolic process
GO:0007568aging
GO:0009395phospholipid catabolic process
GO:0016042lipid catabolic process
GO:0035900response to isolation stress
GO:1903999negative regulation of eating behavior
Vocabulary: INTERPRO
TermDefinition
IPR036866RibonucZ/Hydroxyglut_hydro
IPR024884NAPE-PLD
IPR001279Metallo-B-lactamas
Vocabulary: molecular function
TermDefinition
GO:0004620phospholipase activity
GO:0008270zinc ion binding
GO:0016787hydrolase activity
GO:0046872metal ion binding
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001279Metallo-beta-lactamasePFAMPF12706Lactamase_B_2coord: 101..302
e-value: 7.9E-34
score: 116.9
IPR036866Ribonuclease Z/Hydroxyacylglutathione hydrolase-likeGENE3DG3DSA:3.60.15.10coord: 56..350
e-value: 6.5E-84
score: 283.4
IPR036866Ribonuclease Z/Hydroxyacylglutathione hydrolase-likeSUPERFAMILYSSF56281Metallo-hydrolase/oxidoreductasecoord: 83..312
IPR024884N-acyl-phosphatidylethanolamine-hydrolysing phospholipase DPIRSFPIRSF038896NAPE-PLDcoord: 4..344
e-value: 3.2E-101
score: 336.6
NoneNo IPR availablePANTHERPTHR15032FAMILY NOT NAMEDcoord: 17..344