3 hydroxyacyl CoA dehydrogenase type-2

Overview
Name3 hydroxyacyl CoA dehydrogenase type-2 (AFJ24806.1)
Smed IDSMED30014815
Length (bp)893
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of 3 hydroxyacyl CoA dehydrogenase type-2 (SMED30014815) t-SNE clustered cells

Violin plots show distribution of expression levels for 3 hydroxyacyl CoA dehydrogenase type-2 (SMED30014815) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 3 hydroxyacyl CoA dehydrogenase type-2 (SMED30014815) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for 3 hydroxyacyl CoA dehydrogenase type-2 (SMED30014815) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014815

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30014815h1SMcG0007046 SmedASXL_005891SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30014815h1SMcG0007044 Contig34596newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014815h1SMcG0007044 Contig34596uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014815h1SMcG0007046 Contig34596newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014815h1SMcG0007046 Contig34596uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30014815h1SMcG0007046 dd_Smed_v4_1682_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Match: HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol;Acc:HGNC:4800])

HSP 1 Score: 270.011 bits (689), Expect = 4.450e-90
Identity = 134/238 (56.30%), Postives = 165/238 (69.33%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT ERL   G    + DL       + K L     F  ADV+SE+DV   L        ++D+ VNCAGI +A K YN KK   H L +F++VL VN +GTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+ +G+RV+TIAPGLF TPLL SLPE V   LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP 261
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Match: HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol;Acc:HGNC:4800])

HSP 1 Score: 246.899 bits (629), Expect = 4.176e-81
Identity = 127/238 (53.36%), Postives = 156/238 (65.55%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT ERL   G    + DL       + K L     F  ADV+SE+DV   L        ++D+ VNCAGI +A K YN KK   H L +F++VL VN +GTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+ +         GLF TPLL SLPE V   LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI---------GLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP 252
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Match: HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol;Acc:HGNC:4800])

HSP 1 Score: 120.553 bits (301), Expect = 5.453e-33
Identity = 62/139 (44.60%), Postives = 83/139 (59.71%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQ 513
             AT ERL   G    + DL       + K L     F  ADV+SE+DV   L        ++D+ VNCAGI +A K YN KK   H L +F++VL VN +GTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ
Sbjct:   24 LATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQ 162
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Match: CBR4 (carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891])

HSP 1 Score: 94.7449 bits (234), Expect = 2.218e-22
Identity = 66/200 (33.00%), Postives = 99/200 (49.50%), Query Frame = 1 
Query:  217 DVSSEEDVTKGLQHVSYHAKKLDILVNCAGI---GIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMM 807
            DV+ E DV    + +  H  +++ LVN AGI   G+ V+   K +D+   L         N +G+     L C    +      QQ G IVN  SI    G  GQ+ YSASKG +VG +  LA++++   +RV  +APG   T + + L E    HL   IP   R G   E AH V  ++E+P + G V+ +DG  +++
Sbjct:   56 DVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVR--TKTEDMVSQL-------HTNLLGSM----LTCKAAMRTMIQ--QQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEE---HLKKNIPLG-RFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLI 236
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Match: HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14 [Source:HGNC Symbol;Acc:HGNC:23238])

HSP 1 Score: 79.337 bits (194), Expect = 1.269e-16
Identity = 66/207 (31.88%), Postives = 94/207 (45.41%), Query Frame = 1 
Query:  145 GCKVGIFDLNEP------KTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSE--FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESL------PENVQRHLATTIPFPERLGHPDE 723
            G +V I D +E       + LP G+ F+  DV+ E+DV   +        +LD +VN AG       ++     P   S   F ++L++N +GT+ + +L      K+Q N       ++N SS+    GQ     Y A+KGA+  MT  LA D S  GVRV  I+PG   TPL E L      P    R      P   R+G P E
Sbjct:   33 GARVVICDKDESGGRALEQELP-GAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAG-------HHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGN-------VINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPL-GRMGQPAE 223
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Match: ard-1 (Alcohol/Ribitol Dehydrogenase family [Source:UniProtKB/TrEMBL;Acc:A0A061AD09])

HSP 1 Score: 229.95 bits (585), Expect = 9.294e-75
Identity = 120/232 (51.72%), Postives = 147/232 (63.36%), Query Frame = 1 
Query:  121 TVERLAKLGCKVGIFDLNEPKTLPE----GSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRM 804
              E LAK G +V I DL + K        G  F  A V+SEE+V      V     +LD LVNCAGI  A K+Y+ +K       +  + + VN +GTFN+IR    L  +++ + N QRGV++NT+S+AAFDGQ GQ+AYSASKGAIVGMTLPLARD +  G+R  TIAPGL  TPLL SLPE V+  LA  IP P RLGHP E+   VQ +IEN  LNGE IR DGA RM
Sbjct:   25 AAEVLAKAGAQVAILDLPQSKGADVAKEIGGIFTPASVTSEEEVRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGTFNVIRHGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLARDFAGDGIRFNTIAPGLMDTPLLSSLPEKVKSFLAQLIPNPSRLGHPHEYGALVQHIIENQYLNGETIRFDGALRM 256
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Match: ard-1 (Alcohol/Ribitol Dehydrogenase family [Source:UniProtKB/TrEMBL;Acc:A0A061AD09])

HSP 1 Score: 104.76 bits (260), Expect = 2.576e-28
Identity = 52/82 (63.41%), Postives = 57/82 (69.51%), Query Frame = 1 
Query:  559 MTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRM 804
            MTLPLARD +  G+R  TIAPGL  TPLL SLPE V+  LA  IP P RLGHP E+   VQ +IEN  LNGE IR DGA RM
Sbjct:    1 MTLPLARDFAGDGIRFNTIAPGLMDTPLLSSLPEKVKSFLAQLIPNPSRLGHPHEYGALVQHIIENQYLNGETIRFDGALRM 82
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Match: ard-1 (Alcohol/Ribitol Dehydrogenase family [Source:UniProtKB/TrEMBL;Acc:A0A061AD09])

HSP 1 Score: 104.76 bits (260), Expect = 2.576e-28
Identity = 52/82 (63.41%), Postives = 57/82 (69.51%), Query Frame = 1 
Query:  559 MTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRM 804
            MTLPLARD +  G+R  TIAPGL  TPLL SLPE V+  LA  IP P RLGHP E+   VQ +IEN  LNGE IR DGA RM
Sbjct:    1 MTLPLARDFAGDGIRFNTIAPGLMDTPLLSSLPEKVKSFLAQLIPNPSRLGHPHEYGALVQHIIENQYLNGETIRFDGALRM 82
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Match: dhs-25 (DeHydrogenases, Short chain [Source:UniProtKB/TrEMBL;Acc:Q19246])

HSP 1 Score: 84.7297 bits (208), Expect = 4.452e-19
Identity = 69/218 (31.65%), Postives = 103/218 (47.25%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPKTL--------PEGSYFVKADVSSEEDVTKGLQHVSYHAKKL---DILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFV 738
            A  + LAK G +V + DL+              +       DVS+ + V KGL   S H K L    ILVNCAGI     +   K++      +++ V+KVN  G F++ +     F K   + N     I+N SSI    G  GQ  Y+A+K  ++G T   A++L+   VRV  + PG   TP+ E++P  V   +   IP   R+G  +E A+ V
Sbjct:   22 AISQTLAKHGARVVVADLDSGNAAATAKALPASQSHSSFACDVSNADSV-KGL---SEHVKSLGTPSILVNCAGITKDSTLLKMKQE------QWDSVIKVNLTGVFHVSQA----FVKASVDNNNHPLSIINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVLPGFIKTPMTEAMPPTVLAEICKGIPMG-RMGEAEEIANSV 224
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Match: dhs-11 (DeHydrogenases, Short chain [Source:UniProtKB/TrEMBL;Acc:A0A168H2Z9])

HSP 1 Score: 75.485 bits (184), Expect = 8.666e-16
Identity = 60/217 (27.65%), Postives = 98/217 (45.16%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPKT------LP-EGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGV---IVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFV 738
            A  ++ A  G ++ + DL +         LP  G    + DVS  E V +  + +    +   +LVNCAGI     +    ++      +++ V+ VN    F M ++           E+   G    IVN SSI    G  GQ  Y+A+K  ++G T   AR+L+   +RV  + PG   TP+ E++P  V   + + +P   RLG  +E A+ V
Sbjct:   19 AICKKFAASGARLIVADLKKSAAEATAGNLPGNGHSAFEIDVSDPEHVARLQEFIKSSGESPSVLVNCAGITKDATLLKMSQN------QWQDVMNVNLNSVFLMSQMIA--------RESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATKNIRVNAVLPGFIRTPMTEAMPPKVLDAMVSMVP-QRRLGETEEIANAV 220
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Match: scu (gene:FBgn0021765 transcript:FBtr0074511)

HSP 1 Score: 286.96 bits (733), Expect = 4.179e-97
Identity = 139/237 (58.65%), Postives = 175/237 (73.84%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL-----NE-PKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            AT ERLAK G  V + DL     NE  K L +   FV  DV+SE+DV+  LQ       +LD+ VNCAG   AVK +N  K++ H L +F++V+ +NT+GTFN+IRL  GL   N+PN++ QRGVIVNT+S+AAFDGQ GQAAYSASK A+VGMTLP+ARDLS  G+R+ TIAPGLF TP+L +LPE V+  LA +IPFP+RLG P E+AH VQ++ ENP+LNGEVIR+DGA RMMP
Sbjct:   19 ATAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVTSEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENPLLNGEVIRIDGALRMMP 255
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Match: scu (gene:FBgn0021765 transcript:FBtr0308351)

HSP 1 Score: 192.586 bits (488), Expect = 7.125e-62
Identity = 87/123 (70.73%), Postives = 106/123 (86.18%), Query Frame = 1 
Query:  442 NQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            N+PN++ QRGVIVNT+S+AAFDGQ GQAAYSASK A+VGMTLP+ARDLS  G+R+ TIAPGLF TP+L +LPE V+  LA +IPFP+RLG P E+AH VQ++ ENP+LNGEVIR+DGA RMMP
Sbjct:    4 NEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENPLLNGEVIRIDGALRMMP 126
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Match: CG3603 (gene:FBgn0029648 transcript:FBtr0070558)

HSP 1 Score: 78.5666 bits (192), Expect = 8.450e-17
Identity = 69/241 (28.63%), Postives = 112/241 (46.47%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLN---EPKTL----PEGSYFVKADVSSEEDVTKGL-QHVSYHAKKLDILVNCAGIGIAVKVYNKKKD---IPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVI--ENPMLNGEVIRLDGATR 801
            AT   LA+ G KV   D N     +T+     E S  ++ DVSS + V   + + +    +   I+VN AGI          +D   +  P  +++ V  VN  GTF    L    + K    +  + G IVN SSI A     GQA Y+A+K  ++  T   +++    G+RV  I PG   TP++  +P++V++ +    P   RLG P+E A  +  +   ++  +NG  I + G  +
Sbjct:   23 ATCRLLARDGAKVIAVDRNLKAAQETVQELGSERSAALEVDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGI---------TRDGYLLKMPERDYDDVYGVNLKGTF----LVTQAYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTEVASKEFGKFGIRVNCILPGYIDTPMVAVVPDSVKQEVVQRCPLG-RLGQPEEIAEVIAFLASPQSSYVNGAAIEVTGGLK 249
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Match: CG3603 (gene:FBgn0029648 transcript:FBtr0332493)

HSP 1 Score: 78.5666 bits (192), Expect = 8.450e-17
Identity = 69/241 (28.63%), Postives = 112/241 (46.47%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLN---EPKTL----PEGSYFVKADVSSEEDVTKGL-QHVSYHAKKLDILVNCAGIGIAVKVYNKKKD---IPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVI--ENPMLNGEVIRLDGATR 801
            AT   LA+ G KV   D N     +T+     E S  ++ DVSS + V   + + +    +   I+VN AGI          +D   +  P  +++ V  VN  GTF    L    + K    +  + G IVN SSI A     GQA Y+A+K  ++  T   +++    G+RV  I PG   TP++  +P++V++ +    P   RLG P+E A  +  +   ++  +NG  I + G  +
Sbjct:   23 ATCRLLARDGAKVIAVDRNLKAAQETVQELGSERSAALEVDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGI---------TRDGYLLKMPERDYDDVYGVNLKGTF----LVTQAYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTEVASKEFGKFGIRVNCILPGYIDTPMVAVVPDSVKQEVVQRCPLG-RLGQPEEIAEVIAFLASPQSSYVNGAAIEVTGGLK 249
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Match: CG10672 (gene:FBgn0035588 transcript:FBtr0077179)

HSP 1 Score: 65.0846 bits (157), Expect = 1.015e-11
Identity = 70/239 (29.29%), Postives = 106/239 (44.35%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFD---------LNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVK-VYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPE-RLGHPDEFAHFVQSVIENP--MLNGEVIRLDG 792
            FA  +RLA+ G  V I           L E + L    + +K  VS  ED  +  +       KL+ILV+ A    AV  V    + +      ++K+  VN   ++ + +    L  +      Q+   IV  SSIA +D      AYS SK A++G+T   A+DL+  G+RV  +APG+  T   ++L EN   + A     P  RLG  +E A  V  ++      + GE I   G
Sbjct:   85 FAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKV------WDKIFDVNVKSSYLLAKEALPLLRQ------QKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVIRTKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGG 311
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Match: hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10 [Source:ZFIN;Acc:ZDB-GENE-041010-201])

HSP 1 Score: 279.256 bits (713), Expect = 7.537e-94
Identity = 140/237 (59.07%), Postives = 162/237 (68.35%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPK------TLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL K G    I DL           L +   F   DV+SE DV   L        K+D+ VNCAGI +AVK YN KKD+PH L +F +V+ VN  GTFN+IRL  G   KN+P+ +  RG IVNT+S+AA+DGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL  LPE VQ  LA  +PFP RLG P EFAH V S+ ENPM+NGEVIRLDGA RM P
Sbjct:   24 ATVERLIKHGASAVILDLPSSDGHKVAAALGDRCAFAPTDVTSESDVRSALDLAKEKYGKVDLAVNCAGIAVAVKTYNFKKDLPHSLEDFTRVITVNIAGTFNVIRLAVGEMGKNEPDADGHRGCIVNTASVAAYDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFATPLLAGLPEKVQSFLARQVPFPSRLGDPAEFAHLVTSIAENPMINGEVIRLDGAIRMQP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:402954])

HSP 1 Score: 90.1225 bits (222), Expect = 6.644e-21
Identity = 71/238 (29.83%), Postives = 114/238 (47.90%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNE------PKTLP-EGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGI-AVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMM 807
            A  + LA+ G ++ +   N+       ++LP E    +  DVS EE+V K  + ++     +  LVN AGI   A+ + +K +D+         VL  N +G+     L C    +N  +     G IVN  S+    G  GQ  YSASK  + G T  LA++++   +RV  +APGL  T +   L E        TIP   R G P E A  V  ++E+P + G+++ +DG  +++
Sbjct:   17 AVSKLLAQRGHRIVLLSRNKEAAQATAQSLPGENHLGLSCDVSKEEEVQKAFETINKTCGTVGFLVNAAGINRDALLLRSKSEDML-------SVLHTNLLGSM----LTCKAAVRNMLSHG---GAIVNIGSVVGVKGNAGQCVYSASKAGLEGFTRSLAKEVASRNIRVNLVAPGLIHTDMTAGLAEEAA---VRTIPLG-RFGEPAEVAQAVLFLLESPYITGQILLVDGGLQLL 236
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:402954])

HSP 1 Score: 90.1225 bits (222), Expect = 6.644e-21
Identity = 71/238 (29.83%), Postives = 114/238 (47.90%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNE------PKTLP-EGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGI-AVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMM 807
            A  + LA+ G ++ +   N+       ++LP E    +  DVS EE+V K  + ++     +  LVN AGI   A+ + +K +D+         VL  N +G+     L C    +N  +     G IVN  S+    G  GQ  YSASK  + G T  LA++++   +RV  +APGL  T +   L E        TIP   R G P E A  V  ++E+P + G+++ +DG  +++
Sbjct:   17 AVSKLLAQRGHRIVLLSRNKEAAQATAQSLPGENHLGLSCDVSKEEEVQKAFETINKTCGTVGFLVNAAGINRDALLLRSKSEDML-------SVLHTNLLGSM----LTCKAAVRNMLSHG---GAIVNIGSVVGVKGNAGQCVYSASKAGLEGFTRSLAKEVASRNIRVNLVAPGLIHTDMTAGLAEEAA---VRTIPLG-RFGEPAEVAQAVLFLLESPYITGQILLVDGGLQLL 236
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Match: hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8 [Source:ZFIN;Acc:ZDB-GENE-010110-1])

HSP 1 Score: 77.7962 bits (190), Expect = 2.331e-16
Identity = 64/216 (29.63%), Postives = 100/216 (46.30%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEP---KTLP--------EGSYFVKADVSSEEDVTKGLQHVSY-HAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFA 729
            A  +R A  G  V + D NE    +TL         +    +  DVSS++ V K +  +   + +   + VN AGI     +   ++D      +F+KV+KVN  GTF    L     +K   +    +G I+   SI    G  GQ  Y++SK  + G+T   A++LS  G+R   + PG   TP+ + +PE V   + + IP   R+G P E A
Sbjct:   24 AVCQRFATEGASVVVADRNEESANQTLELLSREHRGQEHMALGVDVSSKDSVEKLVTSIQRRYFQPPSVCVNAAGITQDEFILKMEED------DFDKVIKVNLKGTF----LVTQAVSKALVSAGSVKGSIITVGSIVGKVGNIGQVNYASSKAGVQGLTRTAAKELSKFGIRCNCVLPGFITTPMTDKVPEKVIDKITSIIPLG-RMGEPAEVA 228
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Match: hsd17b14 (hydroxysteroid (17-beta) dehydrogenase 14 [Source:ZFIN;Acc:ZDB-GENE-040801-24])

HSP 1 Score: 69.3218 bits (168), Expect = 3.117e-13
Identity = 54/165 (32.73%), Postives = 73/165 (44.24%), Query Frame = 1 
Query:  190 PEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLAT 684
            P    FV  D+  EED+ + +        ++D LVN  G     K  ++         EF+ +L +N I  F   +       K Q N       I+N SS+ A  GQ   A Y A+KGAI  MT  +A D S   VRV  I+P   +TPL E L  N +   AT
Sbjct:   60 PGSCKFVSCDMREEEDIKQLINVTVESFGQIDCLVNNVGWHPPHKTTDETSG-----EEFKDLLNLNLISFFLASKYALPYLRKTQGN-------IINLSSLVASIGQKDAAPYVATKGAITAMTKAMAVDESRYQVRVNCISPSNIMTPLWEELAANTEDTAAT 212
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Match: hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10 [Source:NCBI gene;Acc:549265])

HSP 1 Score: 285.034 bits (728), Expect = 5.716e-96
Identity = 142/237 (59.92%), Postives = 169/237 (71.31%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL--NEPKT----LPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL + G    I DL  +E KT    L E   F   DV+SE DV   L+       ++D++VNCAGI +A K YN  K +PH L +F++V+ VN  GTFN+IRL  G   KN P+E+  RGVIVNT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL  LPE V+  LA  +PFP RLG P E+AH VQS++ENPMLNGEVIRLDGA RM P
Sbjct:   23 ATVERLVRQGASAVILDLPKSEGKTVAESLGEKCAFSPTDVTSEADVKNALELARTKFGRVDVVVNCAGIAVAAKTYNLNKQLPHSLEDFQRVINVNIAGTFNVIRLAAGEMGKNDPDEDGHRGVIVNTASVAAFDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFATPLLVGLPEKVRNFLAKQVPFPSRLGDPGEYAHLVQSIVENPMLNGEVIRLDGALRMQP 259
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Match: hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10 [Source:NCBI gene;Acc:549265])

HSP 1 Score: 284.263 bits (726), Expect = 2.914e-95
Identity = 142/237 (59.92%), Postives = 169/237 (71.31%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL--NEPKT----LPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL + G    I DL  +E KT    L E   F   DV+SE DV   L+       ++D++VNCAGI +A K YN  K +PH L +F++V+ VN  GTFN+IRL  G   KN P+E+  RGVIVNT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL  LPE V+  LA  +PFP RLG P E+AH VQS++ENPMLNGEVIRLDGA RM P
Sbjct:   58 ATVERLVRQGASAVILDLPKSEGKTVAESLGEKCAFSPTDVTSEADVKNALELARTKFGRVDVVVNCAGIAVAAKTYNLNKQLPHSLEDFQRVINVNIAGTFNVIRLAAGEMGKNDPDEDGHRGVIVNTASVAAFDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFATPLLVGLPEKVRNFLAKQVPFPSRLGDPGEYAHLVQSIVENPMLNGEVIRLDGALRMQP 294
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:493259])

HSP 1 Score: 88.1965 bits (217), Expect = 3.992e-20
Identity = 61/197 (30.96%), Postives = 97/197 (49.24%), Query Frame = 1 
Query:  217 DVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGI-AVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRM 804
            DVS E ++    + ++ +   +D LVN AGI   A+ +  + +DI   LS       VN +GT    +L        +    QQ G IVN  SI    G  GQ+ Y ASK  ++G +  LA++++   +RV  +APG   T +   L E+    L   +P   R G P+E A  V  ++E+P + G V+ +DG  ++
Sbjct:   55 DVSKENEIQDTFKEITNNLGNVDYLVNSAGIRRDALLLRTRSEDIRSLLS-------VNLVGTIQTCKLAL------RSMIQQQGGAIVNIGSIVGHKGNIGQSIYGASKEGLIGFSKSLAKEVAKRNIRVNVVAPGFIHTDMTLGLEED---SLTKMVPLG-RFGDPEEVAQSVLFLLESPYITGHVLVVDGGLQL 234
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Match: armc8 (armadillo repeat containing 8 [Source:Xenbase;Acc:XB-GENE-493289])

HSP 1 Score: 77.7962 bits (190), Expect = 3.911e-16
Identity = 70/245 (28.57%), Postives = 111/245 (45.31%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNE------PKTLPE--GSY---FVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSL--MGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLG---------HPDEFAHFVQSVIENPMLNGEVIRL 786
            A VE L + G  + + D N         +L E  GS+   F++ DV+ +E +    +    H  +LDILVN AG+       N +KD       +EK ++VN         L   L +K         GVI+N SS+A       Q  YSASK  ++G T  +A   S+   GVR+ T+ P    TPLLES+ +  + ++     + +R+           P   A  + ++IE+   NG V+++
Sbjct:   20 AMVEELLQKGAALALVDQNRIAGELCKASLDEQFGSHRTLFIQCDVTDQEQLKDAFRKTVEHFGRLDILVNNAGV-------NNEKD-------WEKTIEVNLTSVIRGTYLGLELMSKKNGGHG---GVIINISSLAGLTPAAYQPVYSASKHGVIGFTRSIAALASIGNYGVRINTVCPAFVDTPLLESIEK--EENMGEFFKYKDRIKDMMKCYGVLDPTLIAKGMINLIEDDASNGAVMKI 245
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Match: hmgb1 (high mobility group box 1 [Source:Xenbase;Acc:XB-GENE-1001206])

HSP 1 Score: 70.0922 bits (170), Expect = 2.091e-13
Identity = 75/264 (28.41%), Postives = 119/264 (45.08%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLN---EPKTLPEGSYFVKADVSSEE------DVTKGLQHVSYHAKKLD--------ILVNCAGIGIAVKVYNKKKDIPHPLSE--FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAH---FVQSVIENPMLNGEVIRLDGATRMMP*ILWR*LCFKK 843
            A  +RL+  G  V + DL+      TL   S+    ++S +E      DV+K   HV+   +K+         I ++ AGI         K +    LSE  F+ VL VN  G F    L      +      +  G I+N  SI    G  GQ+ Y+ASK  + G+T   A++L+  G+R  T+ PG   TP+ + +P+ V    A  +P   RLG+P++ A    F+ S  ++  + G  I + G  ++   I W    F+K
Sbjct:   17 AICQRLSVEGASVVVVDLDISSANATLQTLSH----NLSGQEHAAFATDVSKA-NHVNSLMQKIQGRYSVPPRIAISSAGI--------TKDEFLLRLSEESFDSVLNVNLKGPF----LITQAVARAIVASGEHGGSIINIGSIVGKVGNLGQSNYAASKAGVEGLTKTAAKELAKFGIRCNTVLPGFISTPMTDKVPQKVLDKFAGMVPLG-RLGYPEDIADVCAFLAS-DDSKYITGASIEVTGNGQISFQIRWH--SFRK 259
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Match: Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10 [Source:MGI Symbol;Acc:MGI:1333871])

HSP 1 Score: 270.011 bits (689), Expect = 3.482e-90
Identity = 129/238 (54.20%), Postives = 169/238 (71.01%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT +RL   G    + D+       + K L E   F  A+V+SE+++   L        ++D+ VNCAGI +A+K Y++KK+  H L +F++V+ VN IGTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+  G+RVVTIAPGLF TPLL +LPE V+  LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAKRLVGQGATAVLLDVPDSEGEAQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP 261
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Match: Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10 [Source:MGI Symbol;Acc:MGI:1333871])

HSP 1 Score: 263.462 bits (672), Expect = 1.956e-87
Identity = 130/248 (52.42%), Postives = 170/248 (68.55%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKV----------LKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT +RL   G    + D+       + K L E   F  A+V+SE+++   L        ++D+ VNCAGI +A+K Y++KK+  H L +F++V          L+VN IGTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+  G+RVVTIAPGLF TPLL +LPE V+  LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAKRLVGQGATAVLLDVPDSEGEAQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINILHHGSTILQVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP 271
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Match: Cbr4 (carbonyl reductase 4 [Source:MGI Symbol;Acc:MGI:2384567])

HSP 1 Score: 94.3597 bits (233), Expect = 1.777e-22
Identity = 67/199 (33.67%), Postives = 100/199 (50.25%), Query Frame = 1 
Query:  211 KADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGI-AVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRM 804
            + DV+ E+DV    Q +  H   ++ LVN AGI   ++ V  K +D+   +S+    L  N +G+     L C    K      QQ G IVN  SI    G  GQ+AYSA+KG +VG +  LA++++   +RV  +APG   T +   L E    H    IP   R G   E AH V  ++E+P + G V+ +DG  ++
Sbjct:   54 RCDVAKEQDVQSTFQEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDM---ISQ----LHTNLLGSM----LTCKAAMKTMI---QQGGSIVNVGSIIGLKGNVGQSAYSATKGGLVGFSRSLAKEVARKKIRVNVVAPGFIRTDMTRHLKEE---HFKKNIPLG-RFGETLEVAHAVVFLLESPYITGHVLIVDGGLQL 234
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Match: Hsd17b14 (hydroxysteroid (17-beta) dehydrogenase 14 [Source:MGI Symbol;Acc:MGI:1913315])

HSP 1 Score: 88.1965 bits (217), Expect = 6.443e-20
Identity = 64/185 (34.59%), Postives = 89/185 (48.11%), Query Frame = 1 
Query:  196 GSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSE--FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLAT----TIPFP-ERLGHPDEFA 729
            G+ F+  DV+ E D+   +         LD +VN AG       Y+    +P   S   F ++L+VN +GT+ +I+L         P+  + RG I+N SS+    GQ     Y A+KGA+  MT  LA D S  GVRV  I+PG   TPL E L  +     AT    T+  P  R+G P E A
Sbjct:   55 GTVFIPGDVTQERDLQTLVSETLSRFGHLDCVVNNAG-------YHPPAQLPEETSAQGFRQLLEVNLLGTYTLIKLAL-------PHLRKSRGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRHGVRVNCISPGNIWTPLWEELAASTSDPRATILEGTLAQPLGRMGQPAEVA 225
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Match: Hpgd (hydroxyprostaglandin dehydrogenase 15 (NAD) [Source:MGI Symbol;Acc:MGI:108085])

HSP 1 Score: 84.7297 bits (208), Expect = 1.029e-18
Identity = 68/245 (27.76%), Postives = 115/245 (46.94%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLN-----------EPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLM--GVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLG---------HPDEFAHFVQSVIENPMLNGEVIRL 786
            A  E L   G KV + D N           + +  P+ + FV+ DV+ ++ +    + V  H  +LDILVN AG+       N +K+       +E+ L++N +   +   L     +K    E    G+I+N SS+A       Q  Y ASK  I+G T   A   +LM  GVR+  I PG   TP+LES+ +  + ++   I + +++          HP   A+ + ++IE+  LNG ++++
Sbjct:   20 AFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGV-------NNEKN-------WEQTLQINLVSVISGTYLGLDYMSKQNGGEG---GIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEK--EENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKI 245
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Match: sp|O18404|HCD2_DROME (3-hydroxyacyl-CoA dehydrogenase type-2 OS=Drosophila melanogaster OX=7227 GN=scu PE=1 SV=1)

HSP 1 Score: 286.96 bits (733), Expect = 4.190e-96
Identity = 139/237 (58.65%), Postives = 175/237 (73.84%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL-----NE-PKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            AT ERLAK G  V + DL     NE  K L +   FV  DV+SE+DV+  LQ       +LD+ VNCAG   AVK +N  K++ H L +F++V+ +NT+GTFN+IRL  GL   N+PN++ QRGVIVNT+S+AAFDGQ GQAAYSASK A+VGMTLP+ARDLS  G+R+ TIAPGLF TP+L +LPE V+  LA +IPFP+RLG P E+AH VQ++ ENP+LNGEVIR+DGA RMMP
Sbjct:   19 ATAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVTSEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENPLLNGEVIRIDGALRMMP 255
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Match: sp|O02691|HCD2_BOVIN (3-hydroxyacyl-CoA dehydrogenase type-2 OS=Bos taurus OX=9913 GN=HSD17B10 PE=1 SV=3)

HSP 1 Score: 270.781 bits (691), Expect = 1.099e-89
Identity = 132/238 (55.46%), Postives = 166/238 (69.75%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT ERL   G    + DL       + K L +   F  ADV+SE+DV   L        ++D+ VNCAGI +A K YN KK   H L +F++V+ VN IGTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+ MG+RV+TIAPGLF TPLL +LP+ V+  LA+ +PFP RLG P E+AH VQ++IEN  LNGEVIRLDGA RM P
Sbjct:   24 LATAERLVGQGATAVLLDLPNSDGETQAKKLGKSCAFAPADVTSEKDVQAALTLAREKFGRVDVAVNCAGIAVASKTYNLKKSQAHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVMTIAPGLFGTPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQAIIENSFLNGEVIRLDGAIRMQP 261
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Match: sp|Q99714|HCD2_HUMAN (3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3)

HSP 1 Score: 270.011 bits (689), Expect = 2.137e-89
Identity = 134/238 (56.30%), Postives = 165/238 (69.33%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT ERL   G    + DL       + K L     F  ADV+SE+DV   L        ++D+ VNCAGI +A K YN KK   H L +F++VL VN +GTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+ +G+RV+TIAPGLF TPLL SLPE V   LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP 261
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Match: sp|O70351|HCD2_RAT (3-hydroxyacyl-CoA dehydrogenase type-2 OS=Rattus norvegicus OX=10116 GN=Hsd17b10 PE=1 SV=3)

HSP 1 Score: 267.7 bits (683), Expect = 1.658e-88
Identity = 129/238 (54.20%), Postives = 169/238 (71.01%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             +T +RL   G    + D+       E K L     F  A+V+SE++V   L        ++D+ VNCAGI +A+K Y++KK+  H L +F++V+ VN IGTFN+IRL  G+  +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG IVGMTLP+ARDL+ +G+RVVTIAPGLF TPLL +LP+ V+  LA+ +PFP RLG P E+AH VQ VIENP LNGEVIRLDGA RM P
Sbjct:   24 LSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRMQP 261
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Match: sp|O08756|HCD2_MOUSE (3-hydroxyacyl-CoA dehydrogenase type-2 OS=Mus musculus OX=10090 GN=Hsd17b10 PE=1 SV=4)

HSP 1 Score: 267.7 bits (683), Expect = 2.177e-88
Identity = 128/238 (53.78%), Postives = 169/238 (71.01%), Query Frame = 1 
Query:  115 FATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
             AT +RL   G    + D+      ++ K L E   F  A+V+SE+++   L        ++D+ VNCAGI +A+K Y++KK+  H L +F++V+ VN IGTFN+IRL  G   +N+P++  QRGVI+NT+S+AAF+GQ GQAAYSASKG I GMTLP+ARDL+  G+RVVTIAPGLF TPLL +LPE V+  LA+ +PFP RLG P E+AH VQ++IENP LNGEVIRLDGA RM P
Sbjct:   24 LATAKRLVGQGATAVLLDVPDSEGESQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIDGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP 261
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Match: I1ZIF2 (3 hydroxyacyl CoA dehydrogenase type-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 502.671 bits (1293), Expect = 9.141e-179
Identity = 260/260 (100.00%), Postives = 260/260 (100.00%), Query Frame = 1 
Query:   31 KFHMAKSLVLSSFKXXXXXXXXXXXXXXFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            KFHMAKSLVLSSFKGLSAVVSGGSSGLGFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP
Sbjct:    1 KFHMAKSLVLSSFKGLSAVVSGGSSGLGFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Match: A0A2C9JID1 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106056571 PE=3 SV=1)

HSP 1 Score: 298.901 bits (764), Expect = 3.152e-98
Identity = 148/237 (62.45%), Postives = 174/237 (73.42%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPK------TLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVER  K G KV + DL   K       L     F   DV+SEEDV+K LQ        L + VNCAGIG+A K YN  K  PH L++F KVL VNT GTFN+IRL  GL   N+PN + QRGVIVNT+S+AAFDGQ GQAAYSASKGAIV MTLP+ARDL+  G+RVVT+APGLF TPLL+ LPE V++ L++TIPFP RLGHP+E+AH VQS++ENP+LNGEVIRLDGA RMMP
Sbjct:   24 ATVERFVKQGAKVVLCDLANSKGQEVAQALGSNCIFTPTDVTSEEDVSKALQLAKDKFGGLQVAVNCAGIGVAFKTYNFNKQRPHELTDFNKVLMVNTGGTFNVIRLAAGLIGSNEPNSDGQRGVIVNTASVAAFDGQMGQAAYSASKGAIVSMTLPIARDLASQGIRVVTVAPGLFDTPLLQQLPEKVRKFLSSTIPFPSRLGHPEEYAHLVQSIVENPLLNGEVIRLDGALRMMP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Match: E9FRN7 (Uncharacterized protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_299789 PE=3 SV=1)

HSP 1 Score: 298.516 bits (763), Expect = 3.774e-98
Identity = 147/237 (62.03%), Postives = 176/237 (74.26%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPKT------LPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVER+ + G +V + DL   K       + E   F   DVSSE+DV   L        KLD+ VNCAGIG+A K YN  K++PH L +F KVL VNT+GTFN+IRL  GL  +NQPNE+ QRGVIVNT+S+AA+DGQ GQAAYSASKGAIVGMTLP+ARDLS  G+RV TIAPGLF TPLLESLPE VQ +LA T+PFP+RLG PDE+A  V+S+I NPM+NGEV+R+DGA RM P
Sbjct:   19 ATVERIVRQGGRVVLCDLPTSKGQQVAAGMSENVIFAPTDVSSEKDVMNALSMTKEKFGKLDVAVNCAGIGVAFKTYNFNKNLPHKLEDFIKVLMVNTVGTFNVIRLSAGLMGENQPNEDGQRGVIVNTASVAAYDGQMGQAAYSASKGAIVGMTLPIARDLSSQGIRVCTIAPGLFKTPLLESLPEKVQSYLAKTVPFPQRLGKPDEYAMMVESIILNPMMNGEVVRVDGAIRMQP 255
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Match: H3B6K3 (Hydroxysteroid 17-beta dehydrogenase 10 OS=Latimeria chalumnae OX=7897 GN=HSD17B10 PE=3 SV=1)

HSP 1 Score: 296.204 bits (757), Expect = 3.675e-97
Identity = 146/237 (61.60%), Postives = 170/237 (71.73%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL K G    I DL      N  KTL EG  F  ADV+SE DV   +        +LDI VNCAGI +AVK YN KKDIPH L +F++V+ VN  GTFN+IRL  G   KN+ + +  RGV++NT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL  LPE VQ  LA  +PFP RLG P E+AH VQ+++ENPMLNGEVIRLDGA RM P
Sbjct:   24 ATVERLLKQGANAVILDLPSSDGANVAKTLGEGCVFAPADVTSEADVKAAVALAREKFGRLDIAVNCAGIAVAVKTYNFKKDIPHTLEDFQRVINVNIAGTFNVIRLSAGEMGKNEADSDGHRGVVINTASVAAFDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFATPLLAGLPEKVQTFLARQVPFPSRLGDPGEYAHLVQAIVENPMLNGEVIRLDGAIRMQP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Match: A0A3S0ZQZ8 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_011466 PE=3 SV=1)

HSP 1 Score: 296.204 bits (757), Expect = 4.058e-97
Identity = 145/237 (61.18%), Postives = 178/237 (75.11%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVER  + G +V + DL          +L +   F   DV+SE DVT+ L+ V  +  +LD+ VNCAGIG+A K YN  K  PH L++F+KVL VNT G+FN+IRL  G+  + +PN + QRGV+VNT+S+AA+DGQ GQAAYSASKGAIVGMTLP+ARDL+  G+RVVTIAPGLF TPLL SLPE V++ LA+TIPFP RL HPDE+AH VQ+V ENPMLNGEVIRLDGA RMMP
Sbjct:   25 ATVERFVREGARVVLCDLPTSNGKEVADSLGKNCVFAPTDVTSEADVTQALETVKSNFGRLDMAVNCAGIGVAFKTYNFNKKRPHDLADFQKVLMVNTAGSFNVIRLAAGVMGEQEPNADGQRGVVVNTASVAAYDGQMGQAAYSASKGAIVGMTLPIARDLASHGIRVVTIAPGLFDTPLLASLPEKVRKFLASTIPFPSRLAHPDEYAHLVQAVYENPMLNGEVIRLDGALRMMP 261
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Match: hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:NCBI gene;Acc:103024621])

HSP 1 Score: 276.559 bits (706), Expect = 5.907e-93
Identity = 141/237 (59.49%), Postives = 165/237 (69.62%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL---NEPKTLPE-GSY--FVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL   G    I DL   +  K   E G +  F  ADV+SE DV   +        +LD+ VNCAGI +A K YN +K+IPH L +F +V+ VN  GTFN+IRL  G   KN+PN +  RG I+NT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL  LPE VQ  LA  +PFP RLG P EFAH V S++ENPMLNGEVIRLDGA RM P
Sbjct:   24 ATVERLLSQGASAVILDLPSSDGHKVATELGGHCAFAPADVTSESDVQAAVSLAREKFGRLDLAVNCAGIAVAAKTYNFRKEIPHSLEDFTRVITVNIAGTFNVIRLAVGEMGKNEPNADGHRGCIINTASVAAFDGQVGQAAYSASKGGIVGMTLPVARDLAPMGIRVVTIAPGLFSTPLLAGLPEKVQSFLARQVPFPSRLGDPAEFAHLVTSIVENPMLNGEVIRLDGAIRMQP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:103036748])

HSP 1 Score: 91.6633 bits (226), Expect = 1.279e-21
Identity = 70/238 (29.41%), Postives = 111/238 (46.64%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLN------EPKTLPEGSYF-VKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCC-GLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMM 807
            A  + LA+ G +V +   N      +  +LP G +  +  DVS+E+DV +  + ++     +  LVN AGI     +   K +      +   VL  N +G+    R     + +K         G IVN  S+    G  GQ  YSASK  + G T  LAR+L+   + V  +APGL  T +   L E+V+      IP   R G P+E A  V  ++E P + G+V+ +DG  +++
Sbjct:   17 AVAQLLAQRGHRVVVVSRNLEAAQTKANSLPGGDHVGISCDVSNEQDVQRAFETITKTCGPVGYLVNSAGINRDALLMRSKSE------DMVSVLHTNLLGSMFTCRAALRSMLSKG--------GAIVNIGSVVGVKGNAGQCVYSASKAGLEGFTRSLARELASRNITVNLVAPGLIRTDMTAGLKEDVE---GRRIPLG-RFGKPEEVAQAVLFLLETPYVTGQVLLVDGGLQLV 236
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Match: hsd17b14 (hydroxysteroid 17-beta dehydrogenase 14 [Source:NCBI gene;Acc:103039867])

HSP 1 Score: 75.0998 bits (183), Expect = 2.041e-15
Identity = 57/165 (34.55%), Postives = 77/165 (46.67%), Query Frame = 1 
Query:  190 PEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLAT 684
            P    F+  D+S EED+ + +        ++D LVN AG     K  ++         EF+ +L +N I  F   +       K Q N       I+N SS+ A  GQ   A Y A+KGAI+ MT  +A D S   VRV  I+PG  +TPL E L E     LAT
Sbjct:   58 PGSCLFLPCDISKEEDIKRLITVTVEKFGQIDCLVNNAGWHPPHKPTDETT-----AEEFKDLLNLNLINYFLASKFALPYLRKTQGN-------IINVSSLVATIGQKHAAPYVATKGAIISMTKAMAVDESRYNVRVNCISPGNVMTPLWEELAEQTPDALAT 210
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Match: hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8 [Source:NCBI gene;Acc:103023719])

HSP 1 Score: 67.3958 bits (163), Expect = 1.134e-12
Identity = 63/216 (29.17%), Postives = 96/216 (44.44%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEP---KTLP--------EGSYFVKADVSSEEDVTKGLQHVSYHA-KKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFA 729
            A  +R A  G  V + D NE    +TL         +    +  DVS ++ V + +  +  H  +   I V  AGI     + N  ++      +F+KV++VN  GTF    L     +K        +G I+   SI    G  GQ  YSASK  + G+T   A++LS  G+R   I PG   +P+ + +PE V   + T +    R+G P E A
Sbjct:   24 AVCQRFASEGASVVVADRNEESAHETLELLSRNHKGQEHMALGVDVSLKDSVGRLVNTIQSHFFQPPSICVTAAGITQDEFLMNMTEE------DFDKVIQVNLKGTF----LLTQAVSKAAVAAGISKGSIITVGSIVGKVGNVGQINYSASKAGVEGLTRTAAKELSRYGIRCNCILPGFIESPMTDKVPEKVIYKI-TPLILMGRMGKPAEVA 228
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Match: hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8 [Source:NCBI gene;Acc:103023719])

HSP 1 Score: 67.3958 bits (163), Expect = 1.134e-12
Identity = 63/216 (29.17%), Postives = 96/216 (44.44%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEP---KTLP--------EGSYFVKADVSSEEDVTKGLQHVSYHA-KKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFA 729
            A  +R A  G  V + D NE    +TL         +    +  DVS ++ V + +  +  H  +   I V  AGI     + N  ++      +F+KV++VN  GTF    L     +K        +G I+   SI    G  GQ  YSASK  + G+T   A++LS  G+R   I PG   +P+ + +PE V   + T +    R+G P E A
Sbjct:   24 AVCQRFASEGASVVVADRNEESAHETLELLSRNHKGQEHMALGVDVSLKDSVGRLVNTIQSHFFQPPSICVTAAGITQDEFLMNMTEE------DFDKVIQVNLKGTF----LLTQAVSKAAVAAGISKGSIITVGSIVGKVGNVGQINYSASKAGVEGLTRTAAKELSRYGIRCNCILPGFIESPMTDKVPEKVIYKI-TPLILMGRMGKPAEVA 228
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Match: HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol;Acc:HGNC:4800])

HSP 1 Score: 206.838 bits (525), Expect = 7.697e-68
Identity = 95/142 (66.90%), Postives = 116/142 (81.69%), Query Frame = 1 
Query:  385 VNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            VN +G+FN+IRL  G   +N+P+ + QRGVI+NT+S+AA+DGQ GQ AYSASKGAIVGMTLP+ARDL+  G+RV+TIAPGLF TPLL +LPE V+  LA  +PFP RLG P E+A  VQS++ENPMLNGEVIRLDGA RM P
Sbjct:    1 VNVVGSFNVIRLAAGEIGRNEPDCSGQRGVIINTASVAAYDGQVGQVAYSASKGAIVGMTLPIARDLASQGIRVMTIAPGLFATPLLMTLPEKVRDFLARQVPFPSRLGDPSEYAQLVQSILENPMLNGEVIRLDGAIRMQP 142
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Match: bdh2 (3-hydroxybutyrate dehydrogenase, type 2 [Source:NCBI gene;Acc:550507])

HSP 1 Score: 59.6918 bits (143), Expect = 8.533e-11
Identity = 64/241 (26.56%), Postives = 103/241 (42.74%), Query Frame = 1 
Query:  133 LAKLGCKVGIFDLN-----EPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGI---GIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAA-FDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESL------PENVQRHLATTIPFPERLGHPDEFAHFVQSVI--ENPMLNGEVIRLDGATRM 804
             AK G KV   D+N     E + +P G      +V+S++ +    + ++    K+D+L NCAG    G  +   +K  D           + +N  G + MIR       K      Q+ G I+N +S+A+   G   +  YS SK AI+G+T  +A D    G+R   + PG   TP L+        PE  ++          RL  P+E AH    +   E+  + G  + +DG   +
Sbjct:   26 FAKEGAKVIATDINGEALKELEQIP-GIEVGVLNVTSKDQI----EALAAKIDKVDVLFNCAGFVHHGTILDCEDKDWDF---------TMNLNVKGMYYMIR---AFLPKMLA---QKSGSIINMASVASSIKGVANRCVYSTSKAAIIGLTKSVAADFLTEGIRCNAVCPGTVDTPSLQERINAQPDPEKARQDFMAR-QKSGRLAKPEEVAHLCVYLASDESAYVTGNEMVIDGGWSL 245
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Match: zgc:56585 (zgc:56585 [Source:ZFIN;Acc:ZDB-GENE-040426-1084])

HSP 1 Score: 53.1434 bits (126), Expect = 1.380e-8
Identity = 50/206 (24.27%), Postives = 85/206 (41.26%), Query Frame = 1 
Query:  199 SYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLM--GVRVVTIAPGLFLTPLLESLP--------ENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRL 786
            S F++ DV+S  ++         H   +DI++N AGI              +  +E+EK   +N +       L   + +K         GV++N +S+A          Y ASK  +VG +  +A    L   GVRV  + P    TPLL ++         E+++  L  T+     +  P      V  ++E+  LNG V+ +
Sbjct:   29 SIFLQCDVTSATELQDAFNKTKSHFGAIDIVINNAGI--------------NNEAEWEKTFNINLVAVVRSTYLALEILSKG--------GVVINIASMAGLGVIPYAPVYCASKHGVVGFSRAIAGACELQGRGVRVCCVCPTYVDTPLLSTVGRADTMGQFEDLREGLVKTL-MDTPIMQPCSVVEGVIRLLEDDSLNGTVMSV 211
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Match: dhrs4 (dehydrogenase/reductase (SDR family) member 4 [Source:ZFIN;Acc:ZDB-GENE-040426-1498])

HSP 1 Score: 51.2174 bits (121), Expect = 8.082e-8
Identity = 44/148 (29.73%), Postives = 67/148 (45.27%), Query Frame = 1 
Query:  367 FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRG--VIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLP--ENVQRHLATTIPFPERLGHPDEFAHFVQSVIENP--MLNGEVIRLDG 792
            ++KVL VN    F        LF K      ++RG   +V  SS+ A+        Y  SK A++G+T  L+R L+ M +RV  +APGL  T     L   E + +        P R G+P+E A  V  +       + G+ + +DG
Sbjct:  134 WDKVLDVNLKAPF--------LFVKEAAPHMKERGEGAVVFISSVTAYFPNEDIGPYCVSKTALLGLTKALSRPLAAMNIRVNNVAPGLIETGFSAGLTKDEKMMQMFRNVTAIP-RAGYPEEVASLVSFLCSRDAGYITGQTMVVDG 272
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Match: dhrs9 (dehydrogenase/reductase (SDR family) member 9 [Source:ZFIN;Acc:ZDB-GENE-030131-1249])

HSP 1 Score: 48.1358 bits (113), Expect = 1.042e-6
Identity = 46/176 (26.14%), Postives = 77/176 (43.75%), Query Frame = 1 
Query:  208 VKADVSSEEDVTKGLQHVS--YHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQ-RHLATTIPFPERLGHPDEF 726
            V  DV++ E V +  + V        L  LVN AG+ + V   +        + +F   ++VN +G   +   C        P   + RG +VN +S+       G  +YS SK  +   +  L RD+ + G++V+ I PG F T L +    N   R +  T+P   R  + ++F
Sbjct:   91 VSLDVTNNESVKRAAEAVQGIVGDTGLWGLVNNAGVCLPVGPMDW-----LTIEDFRPCMEVNAMGLVAVTLACL-------PMLKRGRGRVVNIASVMG-RLALGGGSYSLSKFCVEAFSDILRRDVRVFGIKVIIIEPGFFKTNLTDEKKFNKSLRDIWATLPKDTRHQYGEDF 253
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Yeast
Match: FOX2 (3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4 [Source:SGD;Acc:S000001717])

HSP 1 Score: 55.0694 bits (131), Expect = 4.953e-9
Identity = 56/172 (32.56%), Postives = 88/172 (51.16%), Query Frame = 1 
Query:  133 LAKLGCKVGIFDLNEP--------KTLPEGSYFVKA-DVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAP 621
             A+ G KV + D+ +P        K   EG+    + DV +E  +   +Q      +++DILVN AGI +  K + K KD      E+  VLKV+   TF++ +    +F K      Q+ G I+NT+S +   G  GQA Y+A+K AI+G +  +A + +  G+ V  IAP
Sbjct:  342 FARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLI--IQTAISKFQRVDILVNNAGI-LRDKSFLKMKD-----EEWFAVLKVHLFSTFSLSKAVWPIFTK------QKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAP 499

HSP 2 Score: 52.373 bits (124), Expect = 4.590e-8
Identity = 43/145 (29.66%), Postives = 72/145 (49.66%), Query Frame = 1 
Query:  277 KLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLES-LPENVQRHLATTIPFPERL 708
            ++D+L+N AGI   V      +       EF  V+ V+  G + + R             +Q+ G I+NT+S A   G  GQA YSA+K  +VG+   LA++ +   + V +IAP L  + + E+ LP ++ + L      PE++
Sbjct:   93 RVDVLINNAGILRDVSFAKMTE------REFASVVDVHLTGGYKLSRAAWPYM------RSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAP-LARSRMTENVLPPHILKQLG-----PEKI 219
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Yeast
Match: OAR1 (Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant [Source:SGD;Acc:S000001538])

HSP 1 Score: 53.5286 bits (127), Expect = 8.553e-9
Identity = 50/171 (29.24%), Postives = 78/171 (45.61%), Query Frame = 1 
Query:  280 LDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQ---PNENQQ--RGVIVNTSSIAAFDGQC---GQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFL-TPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPML 765
            +++L+NCAG+        +   +    S+ + ++ VN +    M  +C     K+Q   P  + Q  R  IVN SSI    G+    G + YSASK A+   T  LA ++    +R  TI+PGL   T ++++LP   +  L  TI        P E A  V S+     L
Sbjct:  114 VNLLINCAGLT------QESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSIL-HSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQNLPVEAKEMLERTIG-ASGTSAPAEIAEEVWSLYSRTAL 276
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Yeast
Match: YMR226C (NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004839])

HSP 1 Score: 48.1358 bits (113), Expect = 4.296e-7
Identity = 39/145 (26.90%), Postives = 63/145 (43.45%), Query Frame = 1 
Query:  202 YFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLT 636
            +  + D++  E +   ++++    K +DILVN AG     K     +       + + V   N     N+ +    +F      + +  G IVN  SIA  D     + Y ASK A+   T  L ++L    +RV+ IAPGL  T
Sbjct:   70 HVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAG-----KALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIF------QAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTKIRVILIAPGLVET 203
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Yeast
Match: IRC24 (Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci [Source:SGD;Acc:S000001475])

HSP 1 Score: 46.2098 bits (108), Expect = 1.998e-6
Identity = 40/150 (26.67%), Postives = 70/150 (46.67%), Query Frame = 1 
Query:  217 DVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENV 666
            D++    +   ++ +     KLD +V  AG+   VK  ++     H + ++E++  VN     +++ LC  L  K+ P      G IV  SS A+     G +AY  SK A+    + +A +     VR V IAPG+  T + + + E +
Sbjct:   59 DITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNS-EHDIKQWERLFDVNFFSIVSLVALCLPLL-KSSPF----VGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRAVCIAPGVVDTQMQKDIRETL 202
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Match: EDO44410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVM2])

HSP 1 Score: 271.937 bits (694), Expect = 1.744e-91
Identity = 142/237 (59.92%), Postives = 167/237 (70.46%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            AT  RL + G +V I DL      N  K L +   F   DV+SE DV + +   +     L+  VNCAGIGIAVK  +K  +  H L  FEKVLKVNT G+FN+IRL      KN+P E  +RGVI NT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+  G+RV TIAPGLFLTPLLESLPE V+  LA T+PFP RLGHPDE+AH VQSV+ENPM+NGE IR+DGA RM P
Sbjct:   24 ATAARLVRNGARVVIADLPSSDGNNVAKELGKNCAFAPTDVTSEADVRQAIAVANEKFGPLNAAVNCAGIGIAVKTLSKTGEA-HALDLFEKVLKVNTTGSFNVIRLVAEQMIKNEPTEGGERGVITNTASVAAFDGQMGQAAYSASKGGIVGMTLPIARDLARNGIRVNTIAPGLFLTPLLESLPEKVRIALAKTVPFPPRLGHPDEYAHLVQSVMENPMMNGETIRIDGALRMQP 259
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Match: EDO44409 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVM1])

HSP 1 Score: 181.8 bits (460), Expect = 2.556e-56
Identity = 96/235 (40.85%), Postives = 138/235 (58.72%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDL------NEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLAT-TIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATR 801
            AT  RL + G +  I DL      N  +       F+   V SE ++   ++        ++  +N A +    ++   +   PHPL  FE+ +K+N +GTFN+ RL       N P++  +RGVIVN SSI   +GQ G+ AY+A+KGAI  MTLP+ARDL+ +G+RV TI+PG+F TP+  +      R   T ++PFP R G P+EFA  VQ+VIENPM+NGE+IR+DGA R
Sbjct:   20 ATAIRLIRAGARAVIVDLPSSEGQNTAQEFGSHCTFIPGHVDSESEIKAAIKVAKEKYGCVNASINTAALNTK-ELTLSESGCPHPLELFEETMKINAVGTFNVARLVAESMATNTPDQEGERGVIVNVSSIHGTEGQSGKVAYAATKGAINAMTLPMARDLAKLGIRVNTISPGIFNTPMFMAGRTKESREAITKSVPFPRRTGKPEEFAQLVQAVIENPMINGEIIRIDGALR 253
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Match: EDO43775 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXH2])

HSP 1 Score: 80.1073 bits (196), Expect = 1.344e-17
Identity = 72/240 (30.00%), Postives = 106/240 (44.17%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNE--PKTLPEG----------SYFVKADVSSEEDVTKGLQHVSYHAKKLD-ILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQ--SVIENPMLNGEVIRLDG 792
            A  E LA  G  V + DL+    K   E           ++F   +V+S  +V   LQ +    ++   ILVN AGI     +   K+       +F+ V+ VN  GTF M +       +N+ N     G I+N SSI A  G  GQA Y+ASK  + G+T   A +L+  G+R   I PG   TP+   +P ++   +   IP   R G P   A  V   +  E+  + G  I + G
Sbjct:   25 AVCEALANRGASVSVIDLHGVGAKETSENLATHNDTTRHTHFA-VNVASSSEVKDLLQAIHKEYQRAPCILVNSAGIAKDALLLKMKEQ------DFDDVIDVNLKGTFLMCQTTAKAMVENKINN----GSIINISSIVAKSGNMGQANYAASKAGVEGLTKVCAIELARFGIRCNAILPGFIDTPMTRKVPAHITEQIKHFIPLG-RFGQPSNIADVVSFLACDESSYITGASIDVTG 252
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Match: EDO25912 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DVB2])

HSP 1 Score: 77.411 bits (189), Expect = 9.065e-17
Identity = 68/223 (30.49%), Postives = 98/223 (43.95%), Query Frame = 1 
Query:  208 VKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCG-LFNKNQPNENQQRGVIVNTSSIAAFDGQCGQ-AAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP*ILWR*LCFKKYNSSDLFDI 870
            V+ADV+ E  V +    +  H  +LD+LVN AGI     +  + +     L+ +++V   N  G+F    LCC     +    +    G IVN SS AA  G  G+   Y+A KGAI  MTL LA++++  G+RV  + PG+  T +  S                   G P+  A   QSV   PM  G + R      +   ILW       Y S  L D+
Sbjct:   57 VQADVADERQVMQLFARLDQHFGRLDVLVNNAGI-----LETQMRLEQMELARWQRVFATNVFGSF----LCCREAIKRMSTRQGGNGGAIVNLSSAAARLGAPGEYIDYAAVKGAIDSMTLGLAKEVAADGIRVNAVRPGVIETEIHAS------------------GGEPERVARVSQSV---PMGRGGLAR-----EVAEAILWLASEQASYTSGALLDV 244
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Match: EDO37490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFM0])

HSP 1 Score: 75.8702 bits (185), Expect = 4.644e-16
Identity = 54/165 (32.73%), Postives = 81/165 (49.09%), Query Frame = 1 
Query:  184 TLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHP---------LSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLES 651
            T P  S+F++ DV+ EED+   +        +LD L+N AG               HP         + +FE + K+N +  F M +       ++ P+  + +G I+N SS+ A  GQ    +Y A+KGAI  MT  LA D +  GVRV +++ G  LTPL ES
Sbjct:   59 TGPGESFFIQCDVTKEEDLKNVVDIAIEKYGQLDCLINNAG--------------THPDATSIDDTSVQDFENLFKLNVVSYFIMCK-------RSLPHLRKTKGNIINMSSLVALIGQQHAVSYVATKGAITSMTRALAIDEAAYGVRVNSLSIGNVLTPLWES 202
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Match: hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10 [Source:NCBI gene;Acc:101170516])

HSP 1 Score: 283.108 bits (723), Expect = 1.662e-95
Identity = 142/237 (59.92%), Postives = 165/237 (69.62%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPK------TLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            ATVERL + G    I DL          +L E   F   DV+SE DV   +        KLD+ VNCAGI +AVK YN KKD+PH L +F++V+ VN  GTFN+IRL  G   KNQP+ +  RG IVNT+S+AAFDGQ GQAAYSASKG IVGMTLP+ARDL+ MG+RVVTIAPGLF TPLL SLPE V+  LA  +PFP RLG P EFAH V S+ ENPM+NGEVIRLDGA RM P
Sbjct:   24 ATVERLVQSGASAVIVDLPSSDGEAVAASLGERCAFAPTDVTSEADVRSAVSLAKEKFGKLDLAVNCAGIAVAVKTYNFKKDVPHSLEDFQRVINVNIAGTFNVIRLAVGEMGKNQPDADGHRGCIVNTASVAAFDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFSTPLLASLPEKVRSFLARQVPFPSRLGDPAEFAHLVTSIAENPMINGEVIRLDGAIRMQP 260
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:101155177])

HSP 1 Score: 85.5001 bits (210), Expect = 2.653e-19
Identity = 65/228 (28.51%), Postives = 105/228 (46.05%), Query Frame = 1 
Query:  133 LAKLGCKVGIFDLNEPKT------LPEGSYFV-KADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSE-FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDG 792
            LA+ GC++ +   NE  +      LP   +     DVS E++V +  + +     ++  LVN AGI       N+   +    SE    +L  N +G      L C    ++  +   +   IVN  S+    G  GQ AYSA+K  + G T  LA++++   VRV  +APG   T +   L E      A +IP   R G P++ A     ++E+P + G+V+ +DG
Sbjct:   24 LAERGCRLAVVSRNEDASRAAVAALPGADHVAFSCDVSQEQEVQRTFESIRRSCGRVTYLVNAAGI-------NRDAVLLRTSSEDMLALLHTNLLGCM----LTCRAAMRDMLH--MRDAAIVNIGSVVGLKGNAGQCAYSATKAGLAGFTRSLAKEVASRNVRVNLLAPGFIHTDMTAGLSEE---QSARSIPLG-RFGEPEDVAQAALFLLESPYVTGQVLVVDG 234
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Match: cbr4 (carbonyl reductase 4 [Source:NCBI gene;Acc:101155177])

HSP 1 Score: 85.5001 bits (210), Expect = 2.653e-19
Identity = 65/228 (28.51%), Postives = 105/228 (46.05%), Query Frame = 1 
Query:  133 LAKLGCKVGIFDLNEPKT------LPEGSYFV-KADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSE-FEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDG 792
            LA+ GC++ +   NE  +      LP   +     DVS E++V +  + +     ++  LVN AGI       N+   +    SE    +L  N +G      L C    ++  +   +   IVN  S+    G  GQ AYSA+K  + G T  LA++++   VRV  +APG   T +   L E      A +IP   R G P++ A     ++E+P + G+V+ +DG
Sbjct:   24 LAERGCRLAVVSRNEDASRAAVAALPGADHVAFSCDVSQEQEVQRTFESIRRSCGRVTYLVNAAGI-------NRDAVLLRTSSEDMLALLHTNLLGCM----LTCRAAMRDMLH--MRDAAIVNIGSVVGLKGNAGQCAYSATKAGLAGFTRSLAKEVASRNVRVNLLAPGFIHTDMTAGLSEE---QSARSIPLG-RFGEPEDVAQAALFLLESPYVTGQVLVVDG 234
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Match: hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8 [Source:NCBI gene;Acc:101165741])

HSP 1 Score: 77.411 bits (189), Expect = 3.191e-16
Identity = 63/223 (28.25%), Postives = 107/223 (47.98%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEPK------TLPE---GSYFVKA--DVSSEEDVTKGLQHV-SYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIR------LCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAH 732
            A  +RLA  G  V + D+N+        +LP+   G   +    DVS ++ V K + ++ + + +   + VN AGI     + N +++      +F++V++VN  G+F + +      + CG            +G I+   SI    G  GQA Y+ASK  + G+T   A++LS  G+R   + PG   TP+ + +PE V   + T +P   R+G P E A 
Sbjct:   24 AVCQRLASEGASVVVADINQESADETFSSLPDNLRGQVHMATVVDVSLKDSVKKLVTNIQTRYFQPPSVCVNTAGITQDEFLLNMEEE------QFDRVIQVNLKGSFLVTQAVAQALVACG----------ASKGSIITVGSIVGKVGNLGQANYAASKAGVEGLTRTAAKELSRFGIRCNCVLPGFITTPMTDKVPEKVISKITTLVPLG-RMGEPAEVAD 229
[Close]
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Match: hpgd (15-hydroxyprostaglandin dehydrogenase [Source:NCBI gene;Acc:101171390])

HSP 1 Score: 72.4034 bits (176), Expect = 1.985e-14
Identity = 71/247 (28.74%), Postives = 117/247 (47.37%), Query Frame = 1 
Query:  118 ATVERLAKLGCKVGIFDLNEP-----KTLPEGSY------FVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRG-VIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLM---GVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPE-------RLG--HPDEFAHFVQSVIENPMLNGEVIRL 786
            A VE L + G KV + D+N+      K+  +  +      F++ DV+    +    Q       +LDI++N AGI       N +K+       +EK + VN         L  GL  ++   E+ +RG  IVN SS+AAF     Q  Y+A+K  ++G T  +A D S++   GVR+  + P    TPLL+S+ +  + ++   I F E       + G   P   A  + ++I +P LNG V+++
Sbjct:   20 AVVEALLRSGAKVSVVDINQSCGDVCKSELDAEFGGDNCAFIQCDVTDGHALRDAFQKTVELFGRLDIVINNAGI-------NNEKN-------WEKTIDVNLTSLIKGTYL--GL--EHMSREHGKRGGTIVNVSSMAAFLHSPHQPVYTATKHGVIGFTRAMA-DASILGNYGVRINALCPAFVDTPLLQSVED--EDNMGKFIKFKEDFKRSMDKFGVLQPSLIAEGMMTLITDPSLNGAVMKI 245
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Match: SMESG000044485.1 (SMESG000044485.1)

HSP 1 Score: 496.123 bits (1276), Expect = 8.873e-180
Identity = 257/257 (100.00%), Postives = 257/257 (100.00%), Query Frame = 1 
Query:   40 MAKSLVLSSFKXXXXXXXXXXXXXXFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 810
            MAKSLVLSSFKGLSAVVSGGSSGLGFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP
Sbjct:    1 MAKSLVLSSFKGLSAVVSGGSSGLGFATVERLAKLGCKVGIFDLNEPKTLPEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLDGATRMMP 257
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Match: SMESG000016829.1 (SMESG000016829.1)

HSP 1 Score: 63.5438 bits (153), Expect = 2.003e-11
Identity = 56/190 (29.47%), Postives = 88/190 (46.32%), Query Frame = 1 
Query:  205 FVKADVSSEEDVTKGLQHVS-YHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNK-NQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLL------------ESLPENVQRHLATTIPFPERLGHPDEFAH 732
            F+  DV  EE++   ++ ++  H +KLD ++N  G        ++K D     S+ + +  VN    F        LF+K + P   +  G I+N SS     GQ     Y+ +KGA+  MT  LA D +  GVRV +++PG+  TPLL             +  EN    + T IP    LG+P++ A 
Sbjct:   56 FLFCDVIIEENIKSVIEFINKTHGEKLDCIINNVG----THPEDRKID-DFSTSDLDFIFNVNVKSHF--------LFSKYSMPLLRKSSGCIINMSSQVGSIGQRNAVTYAITKGAVNAMTKSLALDEAENGVRVNSVSPGIIYTPLLVQNTIDNVRIKGNTFYENEIDKMKTLIPLGA-LGYPEDVAR 231
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Match: SMESG000079254.1 (SMESG000079254.1)

HSP 1 Score: 58.5362 bits (140), Expect = 1.036e-9
Identity = 56/205 (27.32%), Postives = 93/205 (45.37%), Query Frame = 1 
Query:  214 ADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLE--SLPENVQRHL---ATTIPFPERLGHPDEFAHFVQSVIEN--PMLNGEVIRLDGATRMM 807
            AD+++EEDV K  +       KLDIL+N AG+     + N +      +  F+ V+ +N       +R    L N   P+   ++G IVN SS+A         +Y  SK A+   T   A DL+  GVRV  ++PG+ +T L +   + E+  +     + T     R G  +E A+ +  +  +      G +  +DG   +M
Sbjct:   69 ADLTNEEDVKKLAEKTLLEFPKLDILINNAGVISNDTIENVE------MENFDSVMNMN-------LRSVIQLTNLLSPSLIDRKGSIVNVSSVAGTRAFPNVMSYCISKAALEQFTKCTALDLASKGVRVNAVSPGVTVTNLHKRAGMSESAYQAFLEKSKTTHALGRAGESEEIAYSIAFLASDAASFTTGAIFPVDGGRHLM 260
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Match: SMESG000079251.1 (SMESG000079251.1)

HSP 1 Score: 50.0618 bits (118), Expect = 6.081e-7
Identity = 49/182 (26.92%), Postives = 80/182 (43.96%), Query Frame = 1 
Query:  214 ADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTPLLE-------SLPENVQRHLATTIPFPERLGHPDEFAHFV 738
            AD+++E+D+ K  +       +LDIL+N AGI +   +     D      +F+  + +N      +  L         P+  + +G IVN SS+A      G  +Y   K  +   T   A DL+  GVRV  + PG+ LT + +       +  E +QR  A       R G+P E A+ +
Sbjct:   68 ADLANEDDIRKLAEKTLSEFVQLDILINNAGILLNDTIETVSMD------QFDMNINLNLRAVIQLTHLLT-------PSLIKAKGSIVNVSSVAGSKSFPGIMSYCIGKAGLDQFTRCAALDLAKKGVRVNAVNPGVILTDIHKRAGMDESAYQEFLQR--AQLTHALGRFGNPIEVAYSI 234
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Match: SMESG000072520.1 (SMESG000072520.1)

HSP 1 Score: 48.521 bits (114), Expect = 1.775e-6
Identity = 47/196 (23.98%), Postives = 88/196 (44.90%), Query Frame = 1 
Query:  142 LGCKVGIFDL----NEPKTLPEGSYF-VKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKKKDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTSSIAAFDGQCGQAA--------YSASKGAIVGMTLPLARDLSLM--GVRVVTIAPGLFLTPLLE-SLPENVQRHLA 681
            +GC   + +L    NE     +G +F  + D+  EED+ K    +  + K L +L+N AG+ +   +   K +       +  + + N +G     R    L  KN+  + +  G I+N SS+      CG           Y ASK A+  +T  + ++L  +   +RV  I+PGL  T  ++ +  E +++ ++
Sbjct:   34 IGCGRNVENLKNLKNEIPKNAKGEFFPFECDIMKEEDILKMFDFIETNFKSLHLLINNAGLCLEGSILQSKTE------NWNIMFQTNVLGLSICTREAFKLLKKNETTD-EVPGHIINISSL------CGHEVISEKFTHFYCASKFAVTAITEGIRQELREIHSKIRVTQISPGLVATEFVKRAFGEEIEKRMS 216
The following BLAST results are available for this feature:
BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HSD17B104.450e-9056.30hydroxysteroid 17-beta dehydrogenase 10 [Source:HG... [more]
HSD17B104.176e-8153.36hydroxysteroid 17-beta dehydrogenase 10 [Source:HG... [more]
HSD17B105.453e-3344.60hydroxysteroid 17-beta dehydrogenase 10 [Source:HG... [more]
CBR42.218e-2233.00carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:... [more]
HSD17B141.269e-1631.88hydroxysteroid 17-beta dehydrogenase 14 [Source:HG... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ard-19.294e-7551.72Alcohol/Ribitol Dehydrogenase family [Source:UniP... [more]
ard-12.576e-2863.41Alcohol/Ribitol Dehydrogenase family [Source:UniP... [more]
ard-12.576e-2863.41Alcohol/Ribitol Dehydrogenase family [Source:UniP... [more]
dhs-254.452e-1931.65DeHydrogenases, Short chain [Source:UniProtKB/TrE... [more]
dhs-118.666e-1627.65DeHydrogenases, Short chain [Source:UniProtKB/TrE... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scu4.179e-9758.65gene:FBgn0021765 transcript:FBtr0074511[more]
scu7.125e-6270.73gene:FBgn0021765 transcript:FBtr0308351[more]
CG36038.450e-1728.63gene:FBgn0029648 transcript:FBtr0070558[more]
CG36038.450e-1728.63gene:FBgn0029648 transcript:FBtr0332493[more]
CG106721.015e-1129.29gene:FBgn0035588 transcript:FBtr0077179[more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsd17b107.537e-9459.07hydroxysteroid (17-beta) dehydrogenase 10 [Source:... [more]
cbr46.644e-2129.83carbonyl reductase 4 [Source:NCBI gene;Acc:402954][more]
cbr46.644e-2129.83carbonyl reductase 4 [Source:NCBI gene;Acc:402954][more]
hsd17b82.331e-1629.63hydroxysteroid (17-beta) dehydrogenase 8 [Source:Z... [more]
hsd17b143.117e-1332.73hydroxysteroid (17-beta) dehydrogenase 14 [Source:... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsd17b105.716e-9659.92hydroxysteroid (17-beta) dehydrogenase 10 [Source:... [more]
hsd17b102.914e-9559.92hydroxysteroid (17-beta) dehydrogenase 10 [Source:... [more]
cbr43.992e-2030.96carbonyl reductase 4 [Source:NCBI gene;Acc:493259][more]
armc83.911e-1628.57armadillo repeat containing 8 [Source:Xenbase;Acc:... [more]
hmgb12.091e-1328.41high mobility group box 1 [Source:Xenbase;Acc:XB-G... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hsd17b103.482e-9054.20hydroxysteroid (17-beta) dehydrogenase 10 [Source:... [more]
Hsd17b101.956e-8752.42hydroxysteroid (17-beta) dehydrogenase 10 [Source:... [more]
Cbr41.777e-2233.67carbonyl reductase 4 [Source:MGI Symbol;Acc:MGI:23... [more]
Hsd17b146.443e-2034.59hydroxysteroid (17-beta) dehydrogenase 14 [Source:... [more]
Hpgd1.029e-1827.76hydroxyprostaglandin dehydrogenase 15 (NAD) [Sourc... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O18404|HCD2_DROME4.190e-9658.653-hydroxyacyl-CoA dehydrogenase type-2 OS=Drosophi... [more]
sp|O02691|HCD2_BOVIN1.099e-8955.463-hydroxyacyl-CoA dehydrogenase type-2 OS=Bos taur... [more]
sp|Q99714|HCD2_HUMAN2.137e-8956.303-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sap... [more]
sp|O70351|HCD2_RAT1.658e-8854.203-hydroxyacyl-CoA dehydrogenase type-2 OS=Rattus n... [more]
sp|O08756|HCD2_MOUSE2.177e-8853.783-hydroxyacyl-CoA dehydrogenase type-2 OS=Mus musc... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZIF29.141e-179100.003 hydroxyacyl CoA dehydrogenase type-2 (Fragment) ... [more]
A0A2C9JID13.152e-9862.45Uncharacterized protein OS=Biomphalaria glabrata O... [more]
E9FRN73.774e-9862.03Uncharacterized protein OS=Daphnia pulex OX=6669 G... [more]
H3B6K33.675e-9761.60Hydroxysteroid 17-beta dehydrogenase 10 OS=Latimer... [more]
A0A3S0ZQZ84.058e-9761.18Uncharacterized protein OS=Elysia chlorotica OX=18... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsd17b105.907e-9359.49hydroxysteroid 17-beta dehydrogenase 10 [Source:NC... [more]
cbr41.279e-2129.41carbonyl reductase 4 [Source:NCBI gene;Acc:1030367... [more]
hsd17b142.041e-1534.55hydroxysteroid 17-beta dehydrogenase 14 [Source:NC... [more]
hsd17b81.134e-1229.17hydroxysteroid 17-beta dehydrogenase 8 [Source:NCB... [more]
hsd17b81.134e-1229.17hydroxysteroid 17-beta dehydrogenase 8 [Source:NCB... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HSD17B107.697e-6866.90hydroxysteroid 17-beta dehydrogenase 10 [Source:HG... [more]
bdh28.533e-1126.563-hydroxybutyrate dehydrogenase, type 2 [Source:NC... [more]
zgc:565851.380e-824.27zgc:56585 [Source:ZFIN;Acc:ZDB-GENE-040426-1084][more]
dhrs48.082e-829.73dehydrogenase/reductase (SDR family) member 4 [Sou... [more]
dhrs91.042e-626.14dehydrogenase/reductase (SDR family) member 9 [Sou... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
FOX24.953e-932.563-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydr... [more]
OAR18.553e-929.24Mitochondrial 3-oxoacyl-[acyl-carrier-protein] red... [more]
YMR226C4.296e-726.90NADP(+)-dependent serine dehydrogenase and carbony... [more]
IRC241.998e-626.67Putative benzil reductase;(GFP)-fusion protein loc... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO444101.744e-9159.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO444092.556e-5640.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO437751.344e-1730.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO259129.065e-1730.49Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8... [more]
EDO374904.644e-1632.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsd17b101.662e-9559.92hydroxysteroid 17-beta dehydrogenase 10 [Source:NC... [more]
cbr42.653e-1928.51carbonyl reductase 4 [Source:NCBI gene;Acc:1011551... [more]
cbr42.653e-1928.51carbonyl reductase 4 [Source:NCBI gene;Acc:1011551... [more]
hsd17b83.191e-1628.25hydroxysteroid 17-beta dehydrogenase 8 [Source:NCB... [more]
hpgd1.985e-1428.7415-hydroxyprostaglandin dehydrogenase [Source:NCBI... [more]
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BLAST of 3 hydroxyacyl CoA dehydrogenase type-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000044485.18.873e-180100.00SMESG000044485.1[more]
SMESG000016829.12.003e-1129.47SMESG000016829.1[more]
SMESG000079254.11.036e-927.32SMESG000079254.1[more]
SMESG000079251.16.081e-726.92SMESG000079251.1[more]
SMESG000072520.11.775e-623.98SMESG000072520.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30014815
GenBankAFJ24806.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014815 ID=SMED30014815|Name=3 hydroxyacyl CoA dehydrogenase type-2|organism=Schmidtea mediterranea sexual|type=transcript|length=893bp
TTTAAACATAATTGACAAAGCGCAAAGTCAAAATTCCACATGGCTAAATC
ACTGGTTTTGTCATCTTTTAAAGGATTGTCTGCTGTTGTATCTGGTGGAT
CTTCTGGCTTAGGATTTGCTACAGTTGAAAGATTAGCTAAACTCGGGTGT
AAAGTAGGCATTTTTGATCTCAATGAACCTAAAACATTGCCGGAAGGTAG
TTATTTTGTTAAGGCAGACGTCTCCAGTGAAGAAGATGTTACAAAAGGTC
TTCAGCATGTTTCTTATCACGCTAAAAAACTTGATATATTAGTTAATTGT
GCTGGGATTGGTATAGCGGTAAAAGTTTACAATAAAAAGAAAGATATTCC
TCATCCTTTAAGTGAATTTGAAAAAGTTTTAAAGGTGAATACTATTGGTA
CTTTTAACATGATACGATTGTGTTGCGGTTTGTTCAATAAAAATCAACCA
AATGAAAACCAACAAAGGGGGGTAATCGTCAACACATCAAGTATTGCCGC
TTTTGATGGGCAATGCGGTCAAGCTGCATATTCAGCAAGCAAAGGAGCTA
TTGTCGGCATGACTCTCCCTCTGGCTCGTGATTTATCTCTCATGGGTGTC
CGAGTAGTAACCATAGCTCCTGGTTTGTTTTTGACACCTTTATTGGAAAG
CTTACCTGAGAACGTGCAGAGACATTTGGCAACTACCATTCCATTTCCCG
AAAGATTGGGACATCCAGATGAATTTGCTCATTTCGTTCAATCAGTAATC
GAAAATCCAATGTTGAATGGAGAAGTGATCCGATTAGATGGGGCTACTCG
AATGATGCCATAGATCTTATGGCGTTAGTTGTGTTTCAAAAAATACAATT
CGTCTGACTTATTTGATATTTATTAAAAAATTATTTTTTCCGA
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protein sequence of SMED30014815-orf-1

>SMED30014815-orf-1 ID=SMED30014815-orf-1|Name=SMED30014815-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=258bp
MAKSLVLSSFKGLSAVVSGGSSGLGFATVERLAKLGCKVGIFDLNEPKTL
PEGSYFVKADVSSEEDVTKGLQHVSYHAKKLDILVNCAGIGIAVKVYNKK
KDIPHPLSEFEKVLKVNTIGTFNMIRLCCGLFNKNQPNENQQRGVIVNTS
SIAAFDGQCGQAAYSASKGAIVGMTLPLARDLSLMGVRVVTIAPGLFLTP
LLESLPENVQRHLATTIPFPERLGHPDEFAHFVQSVIENPMLNGEVIRLD
GATRMMP*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR036291NAD(P)-bd_dom_sf
IPR002347SDR_fam
IPR016040NAD(P)-bd_dom
IPR020904Sc_DH/Rdtase_CS
Vocabulary: molecular function
TermDefinition
GO:0016491oxidoreductase activity
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002347Short-chain dehydrogenase/reductase SDRPRINTSPR00081GDHRDHcoord: 138..154
score: 33.62
coord: 164..183
score: 39.44
coord: 185..202
score: 35.9
coord: 14..31
score: 40.78
coord: 79..90
score: 52.92
IPR002347Short-chain dehydrogenase/reductase SDRPRINTSPR00080SDRFAMILYcoord: 79..90
score: 53.98
coord: 144..152
score: 53.55
coord: 164..183
score: 40.92
IPR002347Short-chain dehydrogenase/reductase SDRPFAMPF00106adh_shortcoord: 15..207
e-value: 5.5E-40
score: 136.9
NoneNo IPR availableGENE3DG3DSA:3.40.50.720coord: 5..257
e-value: 1.6E-64
score: 219.6
NoneNo IPR availablePANTHERPTHR43658FAMILY NOT NAMEDcoord: 10..256
NoneNo IPR availablePANTHERPTHR43658:SF63-HYDROXYACYL-COA DEHYDROGENASE TYPE-2coord: 10..256
NoneNo IPR availableCDDcd05371HSD10-like_SDR_ccoord: 11..257
e-value: 5.61446E-140
score: 391.267
IPR020904Short-chain dehydrogenase/reductase, conserved sitePROSITEPS00061ADH_SHORTcoord: 151..179
IPR036291NAD(P)-binding domain superfamilySUPERFAMILYSSF51735NAD(P)-binding Rossmann-fold domainscoord: 10..253