Endophilin-A3

Overview


Name	Endophilin-A3
Smed ID	SMED30014810
Length (bp)	1367

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Endophilin-A3 (SMED30014810) t-SNE clustered cells

Violin plots show distribution of expression levels for Endophilin-A3 (SMED30014810) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Endophilin-A3 (SMED30014810) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Endophilin-A3 (SMED30014810) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30014810

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30014810	SMESG000065428.1	Contig4212	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30014810	SMESG000061276.1	Contig4212	GPL15192	PMID:23079596 Forsthoefel et al., 2012
pharynx	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30014810	SMESG000061276.1	Contig51546	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30014810	SMESG000061276.1	Contig51546	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
epidermis	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
Category 4 cell	SMED30014810	SMESG000061276.1	dd_Smed_v4_7468_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Endophilin-A3 vs. Ensembl Human
Match: SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3 [Source:HGNC Symbol;Acc:HGNC:10832])

HSP 1 Score: 267.7 bits (683), Expect = 1.177e-85
Identity = 150/360 (41.67%), Postives = 217/360 (60.28%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  E+L+ E+ ID    +  +IL KTTEYLQPNPA+R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+E+ ++ K + E K  L+  + Q FI PL  L+  D++EI  H +K++GRRL +D     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++ FI+A  DYH Q+ +I + L SKL Q R  A SS     PR     +     S + N +++         +   G +     P CR LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGMLNTVSKIRGQ-VKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYD---YKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL-QMRISAASS----VPRREYKPRPVKRSSSELNGVST------TSVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL 345

[Close]

BLAST of Endophilin-A3 vs. Ensembl Human
Match: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2 [Source:HGNC Symbol;Acc:HGNC:10830])

HSP 1 Score: 267.314 bits (682), Expect = 2.839e-85
Identity = 147/370 (39.73%), Postives = 220/370 (59.46%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANS------SEKPKAPRNVNSYKTASWGSEDTN----SLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ E EK +D       ++L +T EYLQPNPA R KL    T  KI G+  + P YPQ EG + E   ++  E GG   FG +L++  ++ K L E K  L+  + QNFI PL  L + D++EI  H +K++GRRL FD     K++  K+ D +L  A +KFEE+K +A  +M N L+++ E ++ +S+ + A+ DYH QA  I + L  KL ++  EA+S        KP+ P ++   + ++ G   T     + +S   S  +P             P+C+ALYDF  E+  EL F +GD+I L  Q+DENW+EG   G++GFFP+++VEVLVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQ-VKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPL 366

[Close]

BLAST of Endophilin-A3 vs. Ensembl Human
Match: SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1 [Source:HGNC Symbol;Acc:HGNC:10831])

HSP 1 Score: 264.618 bits (675), Expect = 2.332e-84
Identity = 145/361 (40.17%), Postives = 214/361 (59.28%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E E+ +D       +I+ KT EYLQPNPA R KL    T  KI G++ + P YPQ E  ++E   K+  E G +  FG +L E+ +  +EL E K  L+  + QNFI PL  L   D+REI  H +K++GRRL FD     K++  K+ D +L  A +KF+E+K IA  +M N L+ + E ++ +S+ ++A+ +YH QA  I + +  +L ++  +A+S  + +  P+   S +  +  S   N   S   +PK   +       Q   P CRALYDF  E+  EL F +GDII L  Q+DENW+EG   G +GFFPIN+VE+LV L
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQE-KGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGV-------QMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL 350

[Close]

BLAST of Endophilin-A3 vs. Ensembl Human
Match: SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3 [Source:HGNC Symbol;Acc:HGNC:10832])

HSP 1 Score: 249.595 bits (636), Expect = 1.543e-78
Identity = 148/366 (40.44%), Postives = 212/366 (57.92%), Query Frame = 1

Query:   61 FAGIKKQFNKAN--------QLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            FAGI    N+AN        QL SEKI G +GT+L  E+L+ E+ ID    +  +IL KTTEYLQPNPA+R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+E+ ++ K + E K  L+  + Q FI PL  L+  D++EI  H +K++GRRL +D     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++ FI+A  DYH Q+ +I + L SKL Q R  A SS     PR     +     S + N +++         +   G +     P CR LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+VEV+VPL
Sbjct:    5 FAGII--CNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGMLNTVSKIRGQ-VKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYD---YKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL-QMRISAASS----VPRREYKPRPVKRSSSELNGVSTTS------VVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL 353

[Close]

BLAST of Endophilin-A3 vs. Ensembl Human
Match: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2 [Source:HGNC Symbol;Acc:HGNC:10830])

HSP 1 Score: 218.779 bits (556), Expect = 4.443e-67
Identity = 128/369 (34.69%), Postives = 196/369 (53.12%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANS------SEKPKAPRNVNSYKTASWGSEDTNS----LNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ E EK +D       ++L +T EYLQPNP                                                G +L++  ++ K L E K  L+  + QNFI PL  L + D++EI  H +K++GRRL FD     K++  K+ D +L  A +KFEE+K +A  +M N L+++ E ++ +S+ + A+ DYH QA  I + L  KL ++  EA+S        KP+ P ++   + ++ G   T +     +S   S  +P             P+C+ALYDF  E+  EL F +GD+I L  Q+DENW+EG   G++GFFP+++VEVLVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNP------------------------------------------------GDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPL 318

[Close]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Match: unc-57 (Endophilin-A homolog [Source:UniProtKB/Swiss-Prot;Acc:B1V8A0])

HSP 1 Score: 259.996 bits (663), Expect = 1.025e-82
Identity = 141/383 (36.81%), Postives = 221/383 (57.70%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQK--------RDE-------ANSSEKPK----APRNVNSYKTASWGSEDTNS---LNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G++KQFNKANQ +SE +G  + T+L   + E EK +D   +L  D++  T EYLQPNPA R K+       K+ G     P YPQ EG +++   KY  + G N   GKSL + ++T++++ + KY +ED + QNF+ PLT L+ ++++++N HR K++GRRL +D  KR + +     D ++  A++K EE+K +A  +M N L ++ E I+ + + I+A+ D+H Q A   E+L  +L  +        R+E       AN S  P+    AP +++   TA+      N      + P+    P        SQ   P CRAL+DF A+S  EL F +G +I+L+ Q+DENW+EG   GKTG FP+ +V+VLVPL+
Sbjct:    1 MSLSGLRKQFNKANQYLSETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATRAKMATQVALSKVRGTTKTSP-YPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMADIKYQMEDNVKQNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRR-----DDEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRALIEAQLDFHRQTAQCLENLQQQLGHRIKDAAARPREEHVPLSVLANESRTPRSRSPAPSDMSHNSTAAAAMPPQNGGGITQAPPSYQGPPPGGLPPPLSQQQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPLK 377

[Close]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Match: unc-57 (Endophilin-A homolog [Source:UniProtKB/Swiss-Prot;Acc:B1V8A0])

HSP 1 Score: 259.225 bits (661), Expect = 2.436e-82
Identity = 141/385 (36.62%), Postives = 221/385 (57.40%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQK--------RDE-------ANSSEKPK------APRNVNSYKTASWGSEDTNS---LNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G++KQFNKANQ +SE +G  + T+L   + E EK +D   +L  D++  T EYLQPNPA R K+       K+ G     P YPQ EG +++   KY  + G N   GKSL + ++T++++ + KY +ED + QNF+ PLT L+ ++++++N HR K++GRRL +D  KR + +     D ++  A++K EE+K +A  +M N L ++ E I+ + + I+A+ D+H Q A   E+L  +L  +        R+E       AN S  P+      AP +++   TA+      N      + P+    P        SQ   P CRAL+DF A+S  EL F +G +I+L+ Q+DENW+EG   GKTG FP+ +V+VLVPL+
Sbjct:    1 MSLSGLRKQFNKANQYLSETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATRAKMATQVALSKVRGTTKTSP-YPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMADIKYQMEDNVKQNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRR-----DDEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRALIEAQLDFHRQTAQCLENLQQQLGHRIKDAAARPREEHVPLSVLANESRTPRSSFRSPAPSDMSHNSTAAAAMPPQNGGGITQAPPSYQGPPPGGLPPPLSQQQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPLK 379

[Close]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Match: unc-57 (Endophilin-A homolog [Source:UniProtKB/Swiss-Prot;Acc:B1V8A0])

HSP 1 Score: 256.529 bits (654), Expect = 2.412e-81
Identity = 142/387 (36.69%), Postives = 222/387 (57.36%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQK--------RDE-------ANSSEKPK------APRNV--NSYKTASWGSEDTNS---LNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G++KQFNKANQ +SE +G  + T+L   + E EK +D   +L  D++  T EYLQPNPA R K+       K+ G     P YPQ EG +++   KY  + G N   GKSL + ++T++++ + KY +ED + QNF+ PLT L+ ++++++N HR K++GRRL +D  KR + +     D ++  A++K EE+K +A  +M N L ++ E I+ + + I+A+ D+H Q A   E+L  +L  +        R+E       AN S  P+      AP ++  NS   A++     N      + P+    P        SQ   P CRAL+DF A+S  EL F +G +I+L+ Q+DENW+EG   GKTG FP+ +V+VLVPL+
Sbjct:    1 MSLSGLRKQFNKANQYLSETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATRAKMATQVALSKVRGTTKTSP-YPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMADIKYQMEDNVKQNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRR-----DDEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRALIEAQLDFHRQTAQCLENLQQQLGHRIKDAAARPREEHVPLSVLANESRTPRSSFRSPAPSDMSHNSTAAAAFKMPPQNGGGITQAPPSYQGPPPGGLPPPLSQQQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPLK 381

[Close]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Match: unc-57 (Endophilin-A homolog [Source:UniProtKB/Swiss-Prot;Acc:B1V8A0])

HSP 1 Score: 85.8853 bits (211), Expect = 2.799e-20
Identity = 36/64 (56.25%), Postives = 48/64 (75.00%), Query Frame = 1

Query:  943 SQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            SQ   P CRAL+DF A+S  EL F +G +I+L+ Q+DENW+EG   GKTG FP+ +V+VLVPL+
Sbjct:   39 SQQQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPLK 102

[Close]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Match: sorb-1 (SORBin homolog [Source:UniProtKB/TrEMBL;Acc:O62482])

HSP 1 Score: 58.5362 bits (140), Expect = 4.922e-9
Identity = 25/63 (39.68%), Postives = 39/63 (61.90%), Query Frame = 1

Query:  931 KGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEV 1119
            + Y  Q  + T  A+Y F   S  EL  + GDII++I++VD  W EGE  G++G FP ++V++
Sbjct:  146 RDYTPQPVM-TATAVYKFEPRSARELPLNRGDIIRIIREVDGYWMEGERNGRSGIFPTSYVQI 207

HSP 2 Score: 51.2174 bits (121), Expect = 1.106e-6
Identity = 24/54 (44.44%), Postives = 31/54 (57.41%), Query Frame = 1

Query:  964 CRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQ-GKTGFFPINFVEVL 1122
             RA+Y F A S  EL    G+II   +Q+D NW EG  Q G  G FP ++VE +
Sbjct:  218 MRAIYPFTARSDTELSLKRGEIITRRRQIDSNWLEGSNQIGIVGIFPASYVEPI 271

[Close]

BLAST of Endophilin-A3 vs. Ensembl Fly
Match: EndoA (gene:FBgn0038659 transcript:FBtr0083699)

HSP 1 Score: 249.595 bits (636), Expect = 1.007e-78
Identity = 141/371 (38.01%), Postives = 218/371 (58.76%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG--GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK----PKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            MAFAG+KKQ NKANQ ++EK+GG +GT+L  +++E E+  D    L +++ LKT E+LQPNP  R K+ A K   K++G+  +   YPQ EG ++E    Y  + G   +VF ++L+E  +  K++ + KY L+D I QNF+ PL  ++  D++E+  HR+K+QGRRL FD  +R + K     D ++  A+ KF E+  +A   M N L+++ EH++ + +F +A  D+H Q AD+   L   L +KR EA S  +    PK   ++N        +ED    +   ++   P   +    S +        P C+ALYDF  E+P EL F + DII L+ +VD+NWFEG   G+TG+FP ++V+V VPL
Sbjct:    1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQ-AKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK-----DDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPL 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Fly
Match: EndoA (gene:FBgn0038659 transcript:FBtr0334522)

HSP 1 Score: 249.595 bits (636), Expect = 1.007e-78
Identity = 141/371 (38.01%), Postives = 218/371 (58.76%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG--GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK----PKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            MAFAG+KKQ NKANQ ++EK+GG +GT+L  +++E E+  D    L +++ LKT E+LQPNP  R K+ A K   K++G+  +   YPQ EG ++E    Y  + G   +VF ++L+E  +  K++ + KY L+D I QNF+ PL  ++  D++E+  HR+K+QGRRL FD  +R + K     D ++  A+ KF E+  +A   M N L+++ EH++ + +F +A  D+H Q AD+   L   L +KR EA S  +    PK   ++N        +ED    +   ++   P   +    S +        P C+ALYDF  E+P EL F + DII L+ +VD+NWFEG   G+TG+FP ++V+V VPL
Sbjct:    1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQ-AKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK-----DDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPL 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Fly
Match: EndoA (gene:FBgn0038659 transcript:FBtr0083698)

HSP 1 Score: 249.595 bits (636), Expect = 1.007e-78
Identity = 141/371 (38.01%), Postives = 218/371 (58.76%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG--GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK----PKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            MAFAG+KKQ NKANQ ++EK+GG +GT+L  +++E E+  D    L +++ LKT E+LQPNP  R K+ A K   K++G+  +   YPQ EG ++E    Y  + G   +VF ++L+E  +  K++ + KY L+D I QNF+ PL  ++  D++E+  HR+K+QGRRL FD  +R + K     D ++  A+ KF E+  +A   M N L+++ EH++ + +F +A  D+H Q AD+   L   L +KR EA S  +    PK   ++N        +ED    +   ++   P   +    S +        P C+ALYDF  E+P EL F + DII L+ +VD+NWFEG   G+TG+FP ++V+V VPL
Sbjct:    1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQ-AKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK-----DDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPL 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Fly
Match: POSH (gene:FBgn0040294 transcript:FBtr0086828)

HSP 1 Score: 64.3142 bits (155), Expect = 1.348e-10
Identity = 27/59 (45.76%), Postives = 40/59 (67.80%), Query Frame = 1

Query:  955 IPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            +P   AL+DFA+    +L+F  GD+I +  ++D NWF G+  G+ G FPIN+V+V VPL
Sbjct:  137 LPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSVPL 195

HSP 2 Score: 53.1434 bits (126), Expect = 4.421e-7
Identity = 24/59 (40.68%), Postives = 35/59 (59.32%), Query Frame = 1

Query:  955 IPTCRALYDFAAESPNE----LQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEV 1119
            +P C A+YDF    PN+    L+F    +I+++++VD NW EG      G FPI FVE+
Sbjct:  197 MPQCIAMYDFKM-GPNDEEGCLEFKKSTVIQVMRRVDHNWAEGRIGQTIGIFPIAFVEL 254

[Close]

BLAST of Endophilin-A3 vs. Ensembl Fly
Match: Asap (gene:FBgn0050372 transcript:FBtr0300954)

HSP 1 Score: 62.3882 bits (150), Expect = 5.718e-10
Identity = 35/94 (37.23%), Postives = 55/94 (58.51%), Query Frame = 1

Query:  868 SEDTNSLNSQPNSPKQPYIFKKG----YDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQV--DENWFEGEFQG---KTGFFPINFVEVL 1122
            S D + LNS P++P +      G    Y+ Q     CRALYD  A++ +EL+F +G+I+ ++ +   DENW EG  +G   + G FP++FV +L
Sbjct: 1035 SSDNDRLNSSPDNPSKTGGAGLGGKFHYNGQRR---CRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEGQPTRKGMFPVSFVHML 1125

[Close]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Match: sh3gl1a (SH3-domain GRB2-like 1a [Source:ZFIN;Acc:ZDB-GENE-030131-4524])

HSP 1 Score: 263.077 bits (671), Expect = 4.653e-84
Identity = 137/362 (37.85%), Postives = 216/362 (59.67%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPL-YPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ + E+  D       D+L KTTEYLQPNPA R +L  A T  K+ G+   K L YPQ EG + E   KY  + G +  FG +L+E+ +  K L E K  L+  + QNFI P   +   D+++I  H +K++GRRL +D     K++  K+ D +L  A +KFEE+++ A  +M N LD++ E ++ + + ++++  +H Q+  + E L   + ++ ++A S  +P+  R   S  +  +   + ++    P++   P       D     P CRALYDF  E+  EL F++GD+I L  Q+D+NW+EG F+G+TG FP N+VEV+VPLR
Sbjct:    1 MSVAGLKKQFYKASQLMSEKVGGAEGTKLDEDFKDLERKADITSKAISDVLCKTTEYLQPNPASRARLTMANTMSKMRGQ--VKSLGYPQAEGLLGECMLKYGRDMGEDTNFGGALVEMGEAMKRLAEVKDSLDIDVKQNFIDPFQTIVDKDLKDIQHHLKKLEGRRLDYD---YKKKRQGKIADEELRMAMEKFEESRDAAETSMQNLLDTDVEQVSQLCALVESQLQFHKQSMQVLEELAGAMRERVNKAQS--QPRQKRMPVSRPSIDYSDPEDSNGGWNPSAAAPPSYSSTAADQ----PCCRALYDFEPENEGELGFNEGDVITLTNQIDDNWYEGSFRGQTGLFPCNYVEVMVPLR 351

[Close]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Match: sh3gl1b (SH3-domain GRB2-like 1b [Source:ZFIN;Acc:ZDB-GENE-031001-6])

HSP 1 Score: 261.536 bits (667), Expect = 1.906e-83
Identity = 144/360 (40.00%), Postives = 210/360 (58.33%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+Q++SEK+GG +GT+L  E+ + E+ +D       +++ KT+EYLQPNPA R KL    T  KI G+  + P YPQ EG + E   KY  E G    FG +LME+ ++ K L E K  L+  + QNFI PL  L   D+REI  H +K++GRRL +D     K++  K+ D +L  A +KF E+K +A  +M N L+++ E ++ +SS ++++  YH QA  I + L  KL  +  +A +      PR    Y        D    N Q N    P       ++ +    C+ALYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFP+N+VEV+VPL
Sbjct:    1 MSVAGLKKQFYKASQMVSEKVGGAEGTKLDEEFKDLERKVDVTNKAVVEVISKTSEYLQPNPASRAKLSMLNTMSKIRGQ-VKSPGYPQAEGLLGECMGKYGRELGEETNFGGALMEVGESMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQALEKFHESKEVAEISMYNLLETDIEQVSQLSSLVESQLQYHRQAVQILDELSDKLRDRMKDAQTR-----PRK--EYIPKPKPVIDFGETNEQSNGGYTPSSAPPMRNAAAEQACCKALYDFEPENEGELGFHEGDIITLTNQIDENWYEGMLRGQSGFFPLNYVEVIVPL 349

[Close]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Match: sh3gl1a (SH3-domain GRB2-like 1a [Source:ZFIN;Acc:ZDB-GENE-030131-4524])

HSP 1 Score: 259.996 bits (663), Expect = 1.402e-82
Identity = 141/372 (37.90%), Postives = 220/372 (59.14%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPL-YPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGS-EDTN-----SLNSQPNSPKQPYIFKKGYDSQ----STIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ + E+  D       D+L KTTEYLQPNPA R +L  A T  K+ G+   K L YPQ EG + E   KY  + G +  FG +L+E+ +  K L E K  L+  + QNFI P   +   D+++I  H +K++GRRL +D     K++  K+ D +L  A +KFEE+++ A  +M N LD++ E ++ + + ++++  +H Q+  + E L   + ++ ++A S  +P+  R   S  +  +   ED+N     S  + P+       F +    Q    +  P CRALYDF  E+  EL F++GD+I L  Q+D+NW+EG F+G+TG FP N+VEV+VPLR
Sbjct:    1 MSVAGLKKQFYKASQLMSEKVGGAEGTKLDEDFKDLERKADITSKAISDVLCKTTEYLQPNPASRARLTMANTMSKMRGQ--VKSLGYPQAEGLLGECMLKYGRDMGEDTNFGGALVEMGEAMKRLAEVKDSLDIDVKQNFIDPFQTIVDKDLKDIQHHLKKLEGRRLDYD---YKKKRQGKIADEELRMAMEKFEESRDAAETSMQNLLDTDVEQVSQLCALVESQLQFHKQSMQVLEELAGAMRERVNKAQS--QPRQKRMPVSRPSIDYSDPEDSNGGWNPSAAAPPSYSSTAPSFNRASSRQKRNSADQPCCRALYDFEPENEGELGFNEGDVITLTNQIDDNWYEGSFRGQTGLFPCNYVEVMVPLR 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Match: sh3gl1b (SH3-domain GRB2-like 1b [Source:ZFIN;Acc:ZDB-GENE-031001-6])

HSP 1 Score: 259.225 bits (661), Expect = 2.777e-82
Identity = 145/370 (39.19%), Postives = 220/370 (59.46%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK----PKAPRNVNSYKTASWGSEDTNSLNSQP--NSPKQPYIFKKGYDSQSTIP----TCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+Q++SEK+GG +GT+L  E+ + E+ +D       +++ KT+EYLQPNPA R KL    T  KI G+  + P YPQ EG + E   KY  E G    FG +LME+ ++ K L E K  L+  + QNFI PL  L   D+REI  H +K++GRRL +D     K++  K+ D +L  A +KF E+K +A  +M N L+++ E ++ +SS ++++  YH QA  I + L  KL  +  +A +  +    PK P+ V  +   +  S    + +S P   + +  + F +    +  +P     C+ALYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFP+N+VEV+VPL
Sbjct:    1 MSVAGLKKQFYKASQMVSEKVGGAEGTKLDEEFKDLERKVDVTNKAVVEVISKTSEYLQPNPASRAKLSMLNTMSKIRGQV-KSPGYPQAEGLLGECMGKYGRELGEETNFGGALMEVGESMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQALEKFHESKEVAEISMYNLLETDIEQVSQLSSLVESQLQYHRQAVQILDELSDKLRDRMKDAQTRPRKEYIPK-PKPVIDFGETNEQSNGGYTPSSAPPMRNAESYHQFGRITTRKPRLPAEQACCKALYDFEPENEGELGFHEGDIITLTNQIDENWYEGMLRGQSGFFPLNYVEVIVPL 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Match: sh3gl2a (SH3 domain containing GRB2 like 2a, endophilin A1 [Source:ZFIN;Acc:ZDB-GENE-040121-3])

HSP 1 Score: 253.832 bits (647), Expect = 1.578e-80
Identity = 143/360 (39.72%), Postives = 215/360 (59.72%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E EK +D       DIL KTTEYLQPNPA R K+    +  KI G D + P Y Q E  + E   K   E G  + FG +L+++ +  +EL E K  L+  + QNFI PL  +   D++EI  H +K++GRRL FD     K++  KVT+ ++  A +KF+++K IA  +M N L+++ E ++ +S+ ++A+ +YH QAA+I + L SK+  +  EA+   KPK    V   +T+   SE+ N         + P    +        P CRALYDF  E+  EL F +GDII L  ++D+NW+EG   G++GFFP+N+V++LV L
Sbjct:    1 MSVAGLKKQFHKATQRVSEKVGGAEGTKLDVDFTEMEKKVDTTSRAVLDILTKTTEYLQPNPATRAKMSMMSSMSKIRGGD-KGPGYTQTETTLGEAMQKAGRELGEESCFGVALIDVGEAMRELGEVKDALDMEVKQNFIDPLQNIHDKDLKEIQHHLKKLEGRRLDFD---YKKKRQGKVTEDEIKQALEKFDDSKEIAEQSMFNLLENDIEQVSQLSALVQAQVNYHRQAAEILQQLSSKIEDRIREASC--KPKR-EYVPKPRTSLDFSENHNGSIGHSGPSRSPAPMDQ--------PCCRALYDFDPENEGELGFKEGDIITLTSKIDDNWYEGMVNGQSGFFPVNYVDILVAL 345

[Close]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Match: sh3gl1 (SH3-domain GRB2-like 1 [Source:NCBI gene;Acc:619364])

HSP 1 Score: 269.626 bits (688), Expect = 2.093e-86
Identity = 151/361 (41.83%), Postives = 218/361 (60.39%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  E+ E EK +D       D+L KT EYLQPNPA R KL    T  KI G+  + P YPQ EG + ET  K+  + G    FG +L++  ++ K L E K  L+  + QNF+ PL  L   D++EI  H +K++GRRL +D     K++  K+ D +L  A +KF E+K +A  +M N LD++ E ++ +++ ++A+ DYH QA  I + L  KL  +  E++S  K +  P+   SY+ A   SE +N   S P+S K P    +        P C+ALYDF  E+  EL F + DII L  Q+DENW+EG   G++GFFP+N+VE+LVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDEFKEMEKKVDVTTKAVTDVLAKTIEYLQPNPASRAKLSMLNTMSKIRGQ-VKNPGYPQPEGVLGETMIKFGKDLGDESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFLDPLQNLCDKDLKEIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQAMEKFIESKEVAETSMINLLDTDVEQVSQLTALVEAQLDYHRQAVQILDELSEKLKDRVRESSSRTKREFKPKPRESYEYAE--SEQSNGGFSNPSS-KAPAPLDQ--------PCCKALYDFDPENDGELGFRESDIITLTNQIDENWYEGMINGQSGFFPVNYVEILVPL 346

[Close]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Match: gipc2 (GIPC PDZ domain containing family member 2 [Source:Xenbase;Acc:XB-GENE-946803])

HSP 1 Score: 263.848 bits (673), Expect = 3.223e-84
Identity = 147/360 (40.83%), Postives = 218/360 (60.56%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  ++ E E+ ID    +  ++L KTTEYLQPNPA+R +L    T  KI G+  +   YPQ EG + +   ++  E G  + FG +L++  +  K++ E K  L+  + QNFI PL  L+  D++EI  H ++++GRRL +D  KR +    K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ +S F++A  DYH Q+A I E L+++L  + + A+S  +PK      S       +E  +      NS  +P     G       P CRALYDF  E+  EL F +GDII L  Q+DENWFEG   G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDDFQEMERKIDITNKVVAELLSKTTEYLQPNPAYRARLGMLNTMSKIRGQ-VKTTGYPQTEGLLGDCMLRHGRELGDESEFGCALLDAGECMKQMAEVKDSLDINVKQNFIDPLQSLQDKDLKEILYHLKRLEGRRLDYDYKKRRQ---GKIPDEEIRQAVEKFEESKELAERSMFNFLENDIEQVSQLSVFVEAALDYHRQSAQILEDLHNRLHNRMNTASS--RPKRELQHKSIIATLESNEKLHHNGIPSNSSIKP----SGSSGNLDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWFEGMVNGESGFFPINYVEVVVPL 350

[Close]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Match: sh3gl2 (SH3-domain GRB2-like 2 [Source:NCBI gene;Acc:100037852])

HSP 1 Score: 263.077 bits (671), Expect = 7.733e-84
Identity = 149/360 (41.39%), Postives = 215/360 (59.72%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E E+ +D       +I+ KTTEYLQPNPA R KL    T  KI G++ + P YPQ E  ++E   K+  E G    FG +L+++ D  +EL + K  L+  + QNFI PL  L   D+REI  H +K++GRRL FD     K++  K+TD ++  A +KF+E+K IA  +M N L+ + E ++ +S+  +A+ +YH QA+ I + +  KL Q+  EA+S      PR    Y+     S +    NSQ N         K   +    P CRALYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+V++LVPL
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDEDFKEMERKVDVTSRAVMEIMTKTTEYLQPNPASRAKLSMLNTMSKIRGQE-KGPGYPQAEALLAEAMFKFGREIGDESNFGLALIDVGDAMRELSDIKDCLDIDVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFD---YKKKRQGKITDDEIRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALAQAQLEYHRQASQILQQVAVKLEQRIREASSQ-----PRR--EYQPKPRMSLELE--NSQLNGGIALAGTPKPSGAPMDQPCCRALYDFDPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVDILVPL 347

[Close]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Match: sh3gl1 (SH3-domain GRB2-like 1 [Source:NCBI gene;Acc:619364])

HSP 1 Score: 259.61 bits (662), Expect = 2.665e-82
Identity = 147/370 (39.73%), Postives = 219/370 (59.19%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTN-SLNSQPNSPKQPYIFKKGYDSQST--------IPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  E+ E EK +D       D+L KT EYLQPNPA R KL    T  KI G+  + P YPQ EG + ET  K+  + G    FG +L++  ++ K L E K  L+  + QNF+ PL  L   D++EI  H +K++GRRL +D     K++  K+ D +L  A +KF E+K +A  +M N LD++ E ++ +++ ++A+ DYH QA  I + L  KL  +  E++S  K +  P+   SY+ A   SE +N   ++  +       F+    +++          P C+ALYDF  E+  EL F + DII L  Q+DENW+EG   G++GFFP+N+VE+LVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDEFKEMEKKVDVTTKAVTDVLAKTIEYLQPNPASRAKLSMLNTMSKIRGQ-VKNPGYPQPEGVLGETMIKFGKDLGDESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFLDPLQNLCDKDLKEIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQAMEKFIESKEVAETSMINLLDTDVEQVSQLTALVEAQLDYHRQAVQILDELSEKLKDRVRESSSRTKREFKPKPRESYEYAE--SEQSNGGFSNPSSKAPASSSFRSEKPARTNNRSSAPLDQPCCKALYDFDPENDGELGFRESDIITLTNQIDENWYEGMINGQSGFFPVNYVEILVPL 364

[Close]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Match: gipc2 (GIPC PDZ domain containing family member 2 [Source:Xenbase;Acc:XB-GENE-946803])

HSP 1 Score: 244.588 bits (623), Expect = 1.265e-76
Identity = 138/346 (39.88%), Postives = 205/346 (59.25%), Query Frame = 1

Query:   97 QLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            QL SEKI G +GT+L  ++ E E+ ID    +  ++L KTTEYLQPNPA+R +L    T  KI G+  +   YPQ EG + +   ++  E G  + FG +L++  +  K++ E K  L+  + QNFI PL  L+  D++EI  H ++++GRRL +D  KR +    K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ +S F++A  DYH Q+A I E L+++L  + + A+S  +PK      S       +E  +      NS  +P     G       P CRALYDF  E+  EL F +GDII L  Q+DENWFEG   G++GFFPIN+VEV+VPL
Sbjct:   20 QLFSEKISGAEGTKLDDDFQEMERKIDITNKVVAELLSKTTEYLQPNPAYRARLGMLNTMSKIRGQ-VKTTGYPQTEGLLGDCMLRHGRELGDESEFGCALLDAGECMKQMAEVKDSLDINVKQNFIDPLQSLQDKDLKEILYHLKRLEGRRLDYDYKKRRQ---GKIPDEEIRQAVEKFEESKELAERSMFNFLENDIEQVSQLSVFVEAALDYHRQSAQILEDLHNRLHNRMNTASS--RPKRELQHKSIIATLESNEKLHHNGIPSNSSIKP----SGSSGNLDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWFEGMVNGESGFFPINYVEVVVPL 355

[Close]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Match: Sh3gl2 (SH3-domain GRB2-like 2 [Source:MGI Symbol;Acc:MGI:700009])

HSP 1 Score: 271.166 bits (692), Expect = 4.011e-87
Identity = 147/361 (40.72%), Postives = 217/361 (60.11%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E E+ +D       +I+ KT EYLQPNPA R KL    T  KI G++ + P YPQ E  ++E   K+  E G +  FG +L E+ +  +EL E K  L+  + QNFI PL  L   D+REI  H +K++GRRL FD     K++  K+ D +L  A +KF+E+K IA  +M N L+ + E ++ +S+ ++A+ +YH QA  I + +  +L ++  +A+S  + +  P+   S + A+  S   N   S   +PK P +       Q   P CRALYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+VE+LV L
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQE-KGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGV-------QMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVAL 350

[Close]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Match: Sh3gl3 (SH3-domain GRB2-like 3 [Source:MGI Symbol;Acc:MGI:700011])

HSP 1 Score: 271.166 bits (692), Expect = 4.170e-87
Identity = 153/360 (42.50%), Postives = 216/360 (60.00%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  E+L  EK ID       +IL K TEYLQPNPA+R KL    T  K+ G+  +   YPQ EG + +   KY  E G  + FG SL+++ +  K + E K  L+  + Q FI PL  L+  D++EI  H RK++GRRL +D  KR   +  K+ + ++  A +KFEE+K +A  +M NFL+++ E ++ ++ F++A  DYH Q+ +I + L SKL     E   S   K P+     K  +  S D N +    +S K P     G D+ S  P CR LYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLNMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQV-KATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKR---RVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKL-----ELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSS-KTP-----GTDTPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPL 345

[Close]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Match: Sh3gl1 (SH3-domain GRB2-like 1 [Source:MGI Symbol;Acc:MGI:700010])

HSP 1 Score: 264.233 bits (674), Expect = 2.903e-84
Identity = 145/370 (39.19%), Postives = 217/370 (58.65%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK------PKAPRNVNSYKTASWG----SEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ + EK +D       ++L++T EYLQPNPA R KL    T  KI G+  + P YPQ EG + E   ++  E GG   FG +L++  ++ K L E K  L+  + QNFI PL  L   D++EI  H +K++GRRL FD     K++  K+ D +L  A +KFEE+K +A  +M N L+++ E ++ +S+ + A+ DYH QA  I E L  KL ++  EA+S  K      P+ P  +   +  + G         + +S   S  +P             P+C+ALYDF  E+  EL F +GD+I L  Q+DENW+EG   G++GFFP+++V+VLVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKDMEKKVDVTSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQ-VKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGELEQPNGGFPCAPAPKITASSSFRSSDKPIRMPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPL 366

[Close]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Match: Sh3gl3 (SH3-domain GRB2-like 3 [Source:MGI Symbol;Acc:MGI:700011])

HSP 1 Score: 230.335 bits (586), Expect = 9.633e-72
Identity = 132/324 (40.74%), Postives = 188/324 (58.02%), Query Frame = 1

Query:  163 EKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            EK ID       +IL K TEYLQPNPA+R KL    T  K+ G+  +   YPQ EG + +   KY  E G  + FG SL+++ +  K + E K  L+  + Q FI PL  L+  D++EI  H RK++GRRL +D  KR   +  K+ + ++  A +KFEE+K +A  +M NFL+++ E ++ ++ F++A  DYH Q+ +I + L SKL     E   S   K P+     K  +  S D N +    +S K P     G D+ S  P CR LYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFPIN+VEV+VPL
Sbjct:    2 EKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQ-VKATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKR---RVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKL-----ELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSS-KTP-----GTDTPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPL 310

[Close]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Match: Sh3gl2 (SH3-domain GRB2-like 2 [Source:MGI Symbol;Acc:MGI:700009])

HSP 1 Score: 233.032 bits (593), Expect = 2.407e-71
Identity = 132/338 (39.05%), Postives = 197/338 (58.28%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENW 1062
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E E+ +D       +I+ KT EYLQPNPA R KL    T  KI G++ + P YPQ E  ++E   K+  E G +  FG +L E+ +  +EL E K  L+  + QNFI PL  L   D+REI  H +K++GRRL FD     K++  K+ D +L  A +KF+E+K IA  +M N L+ + E ++ +S+ ++A+ +YH QA  I + +  +L ++  +A+S  + +  P+   S + A+  S   N   S   +PK P +       Q   P CRALYDF  E+  EL F +GDII L  Q+DEN 
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQE-KGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGV-------QMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENC 327

[Close]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Match: sp|Q62420|SH3G2_MOUSE (Endophilin-A1 OS=Mus musculus OX=10090 GN=Sh3gl2 PE=1 SV=2)

HSP 1 Score: 271.166 bits (692), Expect = 2.806e-86
Identity = 147/361 (40.72%), Postives = 217/361 (60.11%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E E+ +D       +I+ KT EYLQPNPA R KL    T  KI G++ + P YPQ E  ++E   K+  E G +  FG +L E+ +  +EL E K  L+  + QNFI PL  L   D+REI  H +K++GRRL FD     K++  K+ D +L  A +KF+E+K IA  +M N L+ + E ++ +S+ ++A+ +YH QA  I + +  +L ++  +A+S  + +  P+   S + A+  S   N   S   +PK P +       Q   P CRALYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+VE+LV L
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQE-KGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGV-------QMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVAL 350

[Close]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Match: sp|Q62421|SH3G3_MOUSE (Endophilin-A3 OS=Mus musculus OX=10090 GN=Sh3gl3 PE=1 SV=1)

HSP 1 Score: 270.011 bits (689), Expect = 6.910e-86
Identity = 152/360 (42.22%), Postives = 216/360 (60.00%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  E+L  EK ID       +IL K TEYLQPNPA+R KL    T  K+ G+  +   YPQ EG + +   KY  E G  + FG SL+++ +  K + E K  L+  + Q FI PL  L+  D++EI  H RK++GRRL +D  KR   +  K+ + ++  A +KFEE+K +A  +M NFL+++ E ++ ++ F++A  DYH Q+ +I + L SKL     E   S   K P+     K  +  S D N +    +S K P     G D+ +  P CR LYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLNMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQV-KATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKR---RVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKL-----ELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSS-KTP-----GTDTPADQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPL 345

[Close]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Match: sp|O35180|SH3G3_RAT (Endophilin-A3 OS=Rattus norvegicus OX=10116 GN=Sh3gl3 PE=1 SV=2)

HSP 1 Score: 268.085 bits (684), Expect = 3.712e-85
Identity = 151/363 (41.60%), Postives = 220/363 (60.61%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK---APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  E+L+ EK ID       +IL K TEYLQPNPA+R KL    T  K+ G+  +   YPQ EG + +   KY  E G  + FG SL+E+ +  K + E K  L+  + Q FI PL  L+  D++EI  H RK++GRRL +D     K++  K+ + ++  A +KFEE+K +A  +M NFL+++ E ++ ++ F++A  DYH Q+ +I + L +KL  +   A +S+ P+    P+ VN+  T + G E ++S                G D  S  P CR LYDF  E+  EL F +GDII L  Q+DENW+EG  +G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLDMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKLRGQ-VKATGYPQTEGLLGDCMLKYGRELGEDSAFGNSLVEVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYD---YKKKRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQNKLELRI--ALASQVPRRDYMPKPVNTSSTNANGVEPSSSSKL------------TGTDIPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPL 345

[Close]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Match: sp|Q8AXV0|SH3G1_CHICK (Endophilin-A2 OS=Gallus gallus OX=9031 GN=SH3GL1 PE=1 SV=1)

HSP 1 Score: 268.855 bits (686), Expect = 3.877e-85
Identity = 150/371 (40.43%), Postives = 222/371 (59.84%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSED-TNSLNSQPNSPK--QPYIFKKGYDSQSTI--------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+QL+SEK+GG +GT+L  ++ E EK +D       ++L +T EYLQPNPA R KL    T  KI G+  + P YPQ EG + E+  +Y  E G +  FG +L++  ++ K L E K  L+  + QNFI PL  L   D++EI  H +K++GRRL FD     K++  K+ D +L  A +KFEE+K +A  +M N L+++ E ++ +S+ + A+ DYH QA  I + L  KL ++  EA+S  +P+        +T  +G  D +N   S   +PK      F+     ++++        P C+ALYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFP+N+VEVLVPL
Sbjct:    1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDLTSKAVTEVLTRTIEYLQPNPASRAKLTMLNTMSKIRGQ-VKNPGYPQSEGLLGESMIRYGKELGEDSNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFD---YKKKRQGKIPDEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASS--RPRREYKPKPRETYDFGESDQSNGGFSCTPTPKVSASSSFRSDKPFRTSVRSIPHLDQPCCKALYDFEPENDGELGFKEGDIITLTNQIDENWYEGMINGQSGFFPLNYVEVLVPL 365

[Close]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Match: sp|Q99963|SH3G3_HUMAN (Endophilin-A3 OS=Homo sapiens OX=9606 GN=SH3GL3 PE=1 SV=1)

HSP 1 Score: 267.7 bits (683), Expect = 5.651e-85
Identity = 150/360 (41.67%), Postives = 217/360 (60.28%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL SEKI G +GT+L  E+L+ E+ ID    +  +IL KTTEYLQPNPA+R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+E+ ++ K + E K  L+  + Q FI PL  L+  D++EI  H +K++GRRL +D     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++ FI+A  DYH Q+ +I + L SKL Q R  A SS     PR     +     S + N +++         +   G +     P CR LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+VEV+VPL
Sbjct:    1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGMLNTVSKIRGQ-VKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYD---YKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL-QMRISAASS----VPRREYKPRPVKRSSSELNGVST------TSVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL 345

[Close]

BLAST of Endophilin-A3 vs. TrEMBL
Match: A0A1S3K9F9 (endophilin-A3 isoform X3 OS=Lingula unguis OX=7574 GN=LOC106179882 PE=4 SV=1)

HSP 1 Score: 320.857 bits (821), Expect = 4.823e-103
Identity = 166/369 (44.99%), Postives = 244/369 (66.12%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK--APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYD----SQSTIP---TCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG++KQFNKANQ +SEKIGG KGTEL  E+LE E+ ID    L +D++ +T EYLQPNPA R KL+   T  K+ G+  ++  YPQ EG + ET  K+  + G +  FG+ L+E  ++FK+L + KY LED++ QNF+ PL  L+  D++E+N HR+K+ GRRL +D  KR K+KG+ +++ +L  A++KFEE+K +A  AM N L+++ E I+ ++SFI+A+ DYH +AADI + L+  L  KR+EA S  + +  + +  +S++ +S   +  N+L+S         +   GY      QS+ P    C ALYDF  E+P EL F +GD+I LI Q+DENW+EG   G+TGFFP+N+VEV VPL
Sbjct:    1 MSLAGLRKQFNKANQFMSEKIGGAKGTELDEEFLEMERKIDVTGKLVEDVMARTQEYLQPNPASRAKLMTVNTISKLRGQ-VKQTAYPQPEGILGETMIKHGKDLGDDSSFGQCLVEAGESFKQLADVKYALEDSVKQNFLEPLQHLQNKDLKEVNHHRKKLGGRRLDYDCKKRKKDKGSAISEDELQQAEEKFEESKQLAETAMHNLLENDVEQISQLASFIEAQEDYHRRAADILQQLHDTLQSKRNEAASRPRSEFVSKKVTSSFRNSSPAFD--NNLDS---------LDTTGYSLSPAQQSSEPQQACCTALYDFDPENPGELGFREGDMITLISQIDENWYEGSIHGQTGFFPVNYVEVKVPL 357

[Close]

BLAST of Endophilin-A3 vs. TrEMBL
Match: W6USB0 (Endophilin-A3 OS=Echinococcus granulosus OX=6210 GN=EGR_00480 PE=4 SV=1)

HSP 1 Score: 317.39 bits (812), Expect = 1.229e-101
Identity = 166/364 (45.60%), Postives = 235/364 (64.56%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNE-SGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKE---KGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK-PKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+F G++KQ NKANQ +SEKIGG +GT+L  EY+  EK ID    L ++I+ KT EYLQPNPA R KL    TF+KI GK G+ P YPQ EGQ+ +   KY NE    ++FG+ L++    FK +E+ KY +ED + + +I PL  ++  +++EIN HR+K++GRRL FD  KR KE   +  KV +A++  A++KF+E+K +A  AM NFL S+ EHI+ ++ F+ A+  Y+  A++I E+L+  L++K+DEA S  K    P+ +   +T S      N   S P +P      K       + P CRALY F AE+  EL FS+GDII+LI+QVDENWFEG  + K GFFP+N+VEV+ PL
Sbjct:    1 MSFTGLRKQINKANQFMSEKIGGAEGTKLDEEYIHCEKQIDAMSKLIEEIITKTHEYLQPNPATRAKLATLNTFNKIQGK-GKAPPYPQPEGQLGDCMLKYGNELDHDSLFGECLIQTGYAFKNMEDIKYNMEDQVKREYIEPLRGIQSVELKEINFHRKKLEGRRLDFDCKKRKKESNPQAAKVLEAEIKVAEEKFQESKVLAETAMANFLASDFEHISALAEFVDAQASYYRHASEIMENLHKVLLEKKDEAQSRGKQTHNPKPLQITRTLSGEVSTKNGSMSSPRTPN-----KSPAGDGGSGPCCRALYQFEAENDTELAFSEGDIIQLIRQVDENWFEGRLRDKEGFFPVNYVEVIEPL 358

[Close]

BLAST of Endophilin-A3 vs. TrEMBL
Match: A0A1S3K928 (endophilin-A3 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106179882 PE=4 SV=1)

HSP 1 Score: 315.079 bits (806), Expect = 8.651e-101
Identity = 166/373 (44.50%), Postives = 244/373 (65.42%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGN-VFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEK----GNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK--APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYD----SQSTIP---TCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG++KQFNKANQ +SEKIGG KGTEL  E+LE E+ ID    L +D++ +T EYLQPNPA R KL+   T  K+ G+  ++  YPQ EG + ET  K+  + G +  FG+ L+E  ++FK+L + KY LED++ QNF+ PL  L+  D++E+N HR+K+ GRRL +D  KR K+K    G+ +++ +L  A++KFEE+K +A  AM N L+++ E I+ ++SFI+A+ DYH +AADI + L+  L  KR+EA S  + +  + +  +S++ +S   +  N+L+S         +   GY      QS+ P    C ALYDF  E+P EL F +GD+I LI Q+DENW+EG   G+TGFFP+N+VEV VPL
Sbjct:    1 MSLAGLRKQFNKANQFMSEKIGGAKGTELDEEFLEMERKIDVTGKLVEDVMARTQEYLQPNPASRAKLMTVNTISKLRGQ-VKQTAYPQPEGILGETMIKHGKDLGDDSSFGQCLVEAGESFKQLADVKYALEDSVKQNFLEPLQHLQNKDLKEVNHHRKKLGGRRLDYDCKKRKKDKAPASGSAISEDELQQAEEKFEESKQLAETAMHNLLENDVEQISQLASFIEAQEDYHRRAADILQQLHDTLQSKRNEAASRPRSEFVSKKVTSSFRNSSPAFD--NNLDS---------LDTTGYSLSPAQQSSEPQQACCTALYDFDPENPGELGFREGDMITLISQIDENWYEGSIHGQTGFFPVNYVEVKVPL 361

[Close]

BLAST of Endophilin-A3 vs. TrEMBL
Match: A0A4S2LB47 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008447 PE=4 SV=1)

HSP 1 Score: 314.309 bits (804), Expect = 1.991e-100
Identity = 165/371 (44.47%), Postives = 237/371 (63.88%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGN-VFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKG---NKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKP--------KAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG KKQ NKANQ +SEKIGGV+GT+L  EYLE EK +D    L D+++ +T E+LQPNPAHR K+L   T +K+ GK  +  +YPQ EGQ+ +   KY  + G +  +G+ L++  ++FK L + KY +ED +  NF+ PL  ++  +++EIN HR+K++GRRL FD  KR ++K     K+ + +L  A++KF E+K +A  AM NFL+SE E I  ++  + A+ DYH QA +I E L   L+ K+DEA+S  +P          P  VNS +T S  +  T + N        P++      S    P+CR LYDF AE+ +EL FS+GD+I+L+QQVDENWFEGE  G+ G+FPIN+VEV+ PL
Sbjct:    1 MSLAGFKKQLNKANQFVSEKIGGVEGTKLDDEYLETEKKVDVICKLIDEVVTQTQEFLQPNPAHRAKMLTMNTLNKLQGK-AKSSVYPQPEGQLGDCMQKYGRDLGPDSCYGQCLLQSGESFKYLADIKYTMEDHVKDNFLQPLHSIQTHELKEINHHRKKLEGRRLDFDCKKRKQDKAAATAKLPEDELKIAEEKFVESKILAEQAMINFLNSEVEQIQALTELVTAQVDYHRQATEIMEQLQKFLIDKKDEASSKPRPVYEPKRFSTLPNQVNS-RTPSQSALSTPAKNG-------PHV-NASAPSPILGPSCRGLYDFEAENASELPFSEGDVIRLLQQVDENWFEGELNGRRGYFPINYVEVINPL 361

[Close]

BLAST of Endophilin-A3 vs. TrEMBL
Match: A0A0X3PT28 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR132953 PE=4 SV=1)

HSP 1 Score: 313.538 bits (802), Expect = 3.616e-100
Identity = 160/364 (43.96%), Postives = 235/364 (64.56%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGN-VFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEK---GNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSS-EKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG++KQ NKANQ ++EKIGG +GT+L  EY+  EK ID    L D+I+ +T EYLQPNPA R K+L   TF+KI GK  +   YPQ EGQ+ +   KY  E G + +FG+ L++   +FK LEE K+ +ED +   +I PL  ++  +++EIN HR+K++GRRL +D  KR KE    G K  + ++  A++KF+E+K +A  AM NFL S+ EHI  ++ F+ A+  ++ QA +I E+L+  LM+K+DEA ++ +K    + V  Y T+S      N LN+  N  + P    K   +  + P CRALY F AE+  EL F++GD+I+LI+QVDENW+EG   G+ GFFP+N+VE +V L
Sbjct:    1 MSLAGLRKQINKANQFVTEKIGGAEGTKLDDEYINCEKQIDIMSKLIDEIINRTHEYLQPNPATRAKMLTMNTFNKIQGK-AKTSAYPQPEGQLGDCMLKYGEELGNDSLFGECLVQAGQSFKCLEEVKFHMEDQVKAGYIEPLRGIQSVELKEINFHRKKLEGRRLDYDCKKRRKENNPAGGKAIEDEVKIAEEKFQESKVLAETAMINFLSSDIEHIGALAEFVDAQVTFYRQATEIMENLHKYLMEKKDEAAAAGKKEHIQKPVQRYSTSS------NDLNAAKNGTQSPGTTGKTGTNAESGPCCRALYQFDAENDTELAFAEGDVIQLIRQVDENWYEGRLNGREGFFPVNYVETIVDL 357

[Close]

BLAST of Endophilin-A3 vs. Ensembl Cavefish
Match: ENSAMXT00000053701.1 (endophilin-A1 [Source:NCBI gene;Acc:103033999])

HSP 1 Score: 273.092 bits (697), Expect = 5.820e-88
Identity = 151/361 (41.83%), Postives = 218/361 (60.39%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSP-KQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E EK +D       DI+ +TTEYLQPNPA R KL    T  KI G++ + P YPQ E  + E   K+  E G  + FG +L++ S+  +EL E K  L+  + QNFI PL  L   DI+EI  H +K++GRRL FD     K++  KVTD ++  A +KF+E+K IA  +M N L+S+ E ++ +++ +KA+ +YH QA D+ + L SK+ ++  EA  S KP+              SE+ N       SP + P    +        P+CRALYDF  E+  EL F +GDII L  Q+D+NW+EG   G++GFFPIN+V++LVPL
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMEKKVDTTSRAVLDIMARTTEYLQPNPASRAKLTMINTMSKIRGQE-KGPGYPQAESVLGEAMQKFGRELGEESSFGLALIDASEAMRELGEVKDALDMEVKQNFIDPLQNLHDKDIKEIQHHLKKMEGRRLDFD---YKKKRQGKVTDDEIKQALEKFDESKEIAEQSMFNLLESDIEQVSQLAALVKAQLEYHRQATDVLQQLSSKMEERIKEA--SNKPRKEYIPKPRMELQLPSENHNGGIHTAKSPARSPAPLDQ--------PSCRALYDFEPENEGELGFKEGDIITLTNQIDDNWYEGMIHGQSGFFPINYVDILVPL 347

[Close]

BLAST of Endophilin-A3 vs. Ensembl Cavefish
Match: sh3gl3a (endophilin-A3-like [Source:NCBI gene;Acc:103022507])

HSP 1 Score: 258.455 bits (659), Expect = 3.422e-82
Identity = 146/366 (39.89%), Postives = 223/366 (60.93%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQST-----IPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL+SEKI G +GT+L  +++E E+ ID       ++L KTTEYLQPNPA R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+++ +  K++ + K  L+  + QNFI PL  L+  D++EI  H +K++GRRL FD     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++S I+A  +YH Q+ +I E L SKL  +   ANS  + +  P+++ S    +  ++  N L+   +     +      + + T      P CR+LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+V+VLVPL
Sbjct:    1 MSVAGLKKQFHKASQLLSEKISGAEGTKLDEDFMEMERKIDVTNKSVFELLTKTTEYLQPNPASRAKLGMLNTMSKIRGQ-VKTTGYPQTEGLLGDCMLKYGRELGDESTFGAALVDVGEAMKQMGDVKDSLDIGVKQNFIDPLQTLQDKDLKEIGHHLKKLEGRRLDFD---YKKKRQGKIPDEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLASLIEAALEYHRQSYEILEDLNSKLQNRIATANSQPRKEFKPKSIMS-SLETIDNDQQNGLSYSSSLKSSDHQVTHSVNGKKTELHMDQPCCRSLYDFEPENEGELGFKEGDIIILTNQIDENWYEGMINGESGFFPINYVDVLVPL 361

[Close]

BLAST of Endophilin-A3 vs. Ensembl Cavefish
Match: sh3gl1b (SH3 domain containing GRB2 like 1, endophilin A2 [Source:NCBI gene;Acc:103032391])

HSP 1 Score: 258.455 bits (659), Expect = 3.985e-82
Identity = 148/376 (39.36%), Postives = 221/376 (58.78%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEK----PKAPRNV------NSYKTASWG-SEDTNSLNSQPN-----SPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+Q++SEK+GG +GT+L  E+ + E+ +D       +++ KT+EYLQPNPA R KL    T  KI G+  + P YPQ EG + E   KY  + G    FG +LM++ ++ K L E K  L+  + QNFI PL  L   D+REI  H +K++GRRL +D     K++  K+ D ++  A +KF E+K +A  +M N L+++ E ++ +SS ++++  YH QA  I E L  KL  +  EA S  +    PK P+ V      N +    +  S    + NS+PN     S ++P +      + +    C+ALYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFP+N+VEV+VPL
Sbjct:    1 MSVAGLKKQFYKASQMVSEKVGGAEGTKLDEEFKDLERKVDVTSKAVVELISKTSEYLQPNPASRAKLSMLNTMSKIRGQ-VKSPGYPQAEGLLGECMGKYGRDLGEETNFGLALMDVGESMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYD---YKKKRQGKIPDEEVKQALEKFHESKEVAEISMYNLLETDIEQVSQLSSLVESQLQYHKQAVQILEELSDKLKDRIGEAQSRPRKEYIPK-PKPVFDFGETNDHSNGGFAPSSAPPTRNSEPNLKLGKSSRKPRL------TPAEQACCKALYDFEPENEGELGFREGDIITLTNQIDENWYEGMLHGQSGFFPLNYVEVIVPL 365

[Close]

BLAST of Endophilin-A3 vs. Ensembl Cavefish
Match: sh3gl3a (endophilin-A3-like [Source:NCBI gene;Acc:103022507])

HSP 1 Score: 256.529 bits (654), Expect = 2.784e-81
Identity = 153/381 (40.16%), Postives = 218/381 (57.22%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI---------------------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL+SEKI G +GT+L  +++E E+ ID       ++L KTTEYLQPNPA R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+++ +  K++ + K  L+  + QNFI PL  L+  D++EI  H +K++GRRL FD     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++S I+A  +YH Q+ +I E L SKL  +   ANS      PR    +K  S  S      N Q N        K   D  S I                     P CR+LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+V+VLVPL
Sbjct:    1 MSVAGLKKQFHKASQLLSEKISGAEGTKLDEDFMEMERKIDVTNKSVFELLTKTTEYLQPNPASRAKLGMLNTMSKIRGQ-VKTTGYPQTEGLLGDCMLKYGRELGDESTFGAALVDVGEAMKQMGDVKDSLDIGVKQNFIDPLQTLQDKDLKEIGHHLKKLEGRRLDFD---YKKKRQGKIPDEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLASLIEAALEYHRQSYEILEDLNSKLQNRIATANSQ-----PR--KEFKPKSIMSSLETIDNDQQNGLSYSSSLKSSADHVSYIPPMTHTWPESPRDKTELHMDQPCCRSLYDFEPENEGELGFKEGDIIILTNQIDENWYEGMINGESGFFPINYVDVLVPL 370

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BLAST of Endophilin-A3 vs. Ensembl Cavefish
Match: sh3gl3a (endophilin-A3-like [Source:NCBI gene;Acc:103022507])

HSP 1 Score: 256.144 bits (653), Expect = 5.674e-81
Identity = 148/385 (38.44%), Postives = 231/385 (60.00%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNV-NSYKTASWGSED---------------TNSLNSQPNS----PKQPYIFKKGYDSQSTI----PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA+QL+SEKI G +GT+L  +++E E+ ID       ++L KTTEYLQPNPA R KL    T  KI G+  +   YPQ EG + +   KY  E G  + FG +L+++ +  K++ + K  L+  + QNFI PL  L+  D++EI  H +K++GRRL FD     K++  K+ D ++  A +KFEE+K +A  +M NFL+++ E ++ ++S I+A  +YH Q+ +I E L SKL  +   ANS  + +  P+++ +S +T     ++               T+S+N + +     P   + + +    ++ +    P CR+LYDF  E+  EL F +GDII L  Q+DENW+EG   G++GFFPIN+V+VLVPL
Sbjct:    1 MSVAGLKKQFHKASQLLSEKISGAEGTKLDEDFMEMERKIDVTNKSVFELLTKTTEYLQPNPASRAKLGMLNTMSKIRGQ-VKTTGYPQTEGLLGDCMLKYGRELGDESTFGAALVDVGEAMKQMGDVKDSLDIGVKQNFIDPLQTLQDKDLKEIGHHLKKLEGRRLDFD---YKKKRQGKIPDEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLASLIEAALEYHRQSYEILEDLNSKLQNRIATANSQPRKEFKPKSIMSSLETIDNDQQNGLSYSSSLKSSDHQVTHSVNGKTDHVSYIPPMTHTWPESPRDKTELHMDQPCCRSLYDFEPENEGELGFKEGDIIILTNQIDENWYEGMINGESGFFPINYVDVLVPL 381

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BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Match: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2 [Source:HGNC Symbol;Acc:HGNC:10830])

HSP 1 Score: 231.491 bits (589), Expect = 1.683e-72
Identity = 126/351 (35.90%), Postives = 214/351 (60.97%), Query Frame = 1

Query:   85 NKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK-APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            +K  Q +SEK+GG +GT+L  ++ E EK  D       DI+ KT EYLQPNPA R KL    T  KI G+  +   YPQ EG + E  AKY  + G  + FG +L ++ ++ K++ E K  L+  + QNF+ P+  L+  +++EI  H +K++GRRL FD     K++  K+ D ++  A++KFEE++ +A+ +M N ++SE E ++ +++ + A+ +YH ++A + + L + L ++++EA+   K +   + ++++   SWG+    ++      P           S+S+ P+ +ALYDF  E+  EL F +GDII L +Q+D+NW+EG  +G +GFFP+N+V+V+VPL
Sbjct:   13 HKCTQFVSEKVGGAEGTKLDDDFTEMEKKYDTTNKAVMDIITKTQEYLQPNPASRAKLGMLNTMSKIRGQ-VKSTGYPQPEGLLGEAMAKYGKDMGTESCFGLALADVGESMKQMAEIKDSLDIDVKQNFLDPMQALQDKELKEIGHHLKKLEGRRLDFD---YKKKRLGKIPDEEIRQAEEKFEESREVAASSMHNLVESEIEQVSQLAALVDAQLEYHQRSAAVLQDLQAALQERKNEASKMPKKEFKAKPMSTFHENSWGNGGGENI-----YPAMSGSASASASSRSSAPSAKALYDFDPENEGELGFQEGDIITLTKQIDDNWYEGTVRGHSGFFPVNYVDVIVPL 354

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BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Match: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2 [Source:HGNC Symbol;Acc:HGNC:10830])

HSP 1 Score: 100.908 bits (250), Expect = 1.217e-25
Identity = 57/151 (37.75%), Postives = 91/151 (60.26%), Query Frame = 1

Query:  241 AHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEA 690
            A R KL    T  KI G+  +   YPQ EG + E   KY  + G    FG++L+++ +++KE+ E K GL+  + QNFI PL  L++ ++REI  H +K++GRRL FD     K++  K+ + D+  + +KFEE+K +A  +M N L+S+ 
Sbjct:    1 ASRAKLGMLNTMSKIRGQV-KSTGYPQPEGTLGECMVKYGQDLGEESNFGQALVDVGESYKEMAEVKDGLDIGVKQNFIDPLQGLQEKELREIGQHLKKLEGRRLDFD---YKKKRQGKILEEDIRQSAEKFEESKEVAESSMFNLLESDV 147

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BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Match: SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2 [Source:HGNC Symbol;Acc:HGNC:10834])

HSP 1 Score: 70.8626 bits (172), Expect = 1.224e-13
Identity = 86/388 (22.16%), Postives = 152/388 (39.18%), Query Frame = 1

Query:   82 FNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-----GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNK-----VTDADLDDAQKK----FEEAKNIASDAMDNF----------LDSEAEHINIISSFIKAERDYHHQA--------ADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPT-------CRALYDFAAESPNELQFSDGDIIKL--IQQVDENWFEGEFQGKTGFFPINFVEVL 1122
            F++A Q   EK+G  + TEL + +       +  +H  D I+ +    LQPNP  R   +    F K+ GK    PL        SE   +Y  E+G     G  +G +L++   T KEL   +     T    F++PL      D R I   ++ ++ +RL  D  K   +K         T+ D ++ + +       A  + +D +              D +AE   ++   I +    HH+A        A  +   Y  +++ + E  S   P +  + N+   A+     +       ++P  P     G  S    P         R LYD+ A   +EL     +++ +  +  +D +W  GE   + G  P+ ++E+L
Sbjct:   16 FSRAVQFTEEKLGQAERTELDAHFENLLGRAEMTRHWTDKIMRQAETLLQPNPNAR---IEDYFFEKLEGK---APL----RATNSEYLGQYMIEAGQEFGPGTAYGCALIKCGTTQKELGISEKDFIQTTANGFLTPLRNFLDGDFRTIAKEKKILENKRLDLDACKSRLKKARSAEAKAATEPDFNEIRPRNYVLSASAAGLWADEVARAEQELRVTQTEFDRQAEITRLLLEGIGSTHANHHRALKEFVEAQAAYYAKCYQSMVELQKELGSF--PTSFVSNNNLAGAAGSGAASAGTGGGGSAPPVPTPSILGLPSAEGAPPLVTGTRRARVLYDYDAADMSELSLLADEVVTVYSLPGMDSDWLMGERGNQKGKVPVTYLELL 391

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BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Match: sorbs1 (sorbin and SH3 domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-090313-168])

HSP 1 Score: 63.929 bits (154), Expect = 3.061e-11
Identity = 27/65 (41.54%), Postives = 41/65 (63.08%), Query Frame = 1

Query:  925 FKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEV 1119
            +K+    + T  T RA Y+F A+S  EL    GD++ + +QVD+NW+EGE  G+ G FP  +VE+
Sbjct:  386 WKRTSVGEPTRQTARAKYNFRAQSQKELPLHKGDVVYINRQVDQNWYEGEHHGRVGIFPATYVEL 450

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BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Match: nebl (nebulette [Source:ZFIN;Acc:ZDB-GENE-050320-151])

HSP 1 Score: 58.9214 bits (141), Expect = 3.912e-10
Identity = 24/54 (44.44%), Postives = 37/54 (68.52%), Query Frame = 1

Query:  967 RALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQ--GKTGFFPINFVEVL 1122
            RA+YD+AA   +E+ F DGD+I+ ++Q+DE W  G  Q  G+TG  P N+++ L
Sbjct:  199 RAVYDYAAADDDEVSFLDGDVIENVKQIDEGWMYGTVQRTGQTGMLPANYLQPL 252

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BLAST of Endophilin-A3 vs. Ensembl Yeast
Match: HSE1 (Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994])

HSP 1 Score: 65.855 bits (159), Expect = 4.341e-12
Identity = 24/61 (39.34%), Postives = 39/61 (63.93%), Query Frame = 1

Query:  943 SQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLV 1125
            +Q+ +   RALYD     P+EL F  GD+I +++QV  +W++G  +G  G FP+N+V  +V
Sbjct:  215 AQTVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIV 275

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BLAST of Endophilin-A3 vs. Ensembl Yeast
Match: YSC84 (Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication [Source:SGD;Acc:S000001058])

HSP 1 Score: 61.6178 bits (148), Expect = 8.721e-11
Identity = 26/61 (42.62%), Postives = 37/61 (60.66%), Query Frame = 1

Query:  943 SQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDE--NWFEGEFQGKTGFFPINFVEV 1119
            + S  PT  ALY+FA E P +L F  GD+I ++++ D   +W+ G   GK G FP N+V V
Sbjct:  407 TNSATPTAVALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVRV 467

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BLAST of Endophilin-A3 vs. Ensembl Yeast
Match: LSB3 (Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication [Source:SGD;Acc:S000002968])

HSP 1 Score: 53.9138 bits (128), Expect = 2.357e-8
Identity = 22/57 (38.60%), Postives = 34/57 (59.65%), Query Frame = 1

Query:  958 PTCRALYDFAAESPNELQFSDGDIIKLIQQVDE--NWFEGEFQGKTGFFPINFVEVL 1122
            P   ALY FA E   +L F  GD+I ++++ D   +W+ G   G+ G FP N+VE++
Sbjct:  403 PKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV 459

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BLAST of Endophilin-A3 vs. Ensembl Yeast
Match: RVS167 (Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin [Source:SGD;Acc:S000002796])

HSP 1 Score: 49.2914 bits (116), Expect = 7.609e-7
Identity = 19/55 (34.55%), Postives = 35/55 (63.64%), Query Frame = 1

Query:  961 TCRALYDFAAESPNELQFSDGDIIKLIQQVDE--NWFEGEFQGKTGFFPINFVEV 1119
            T  ALYD+ A++  +L F  G +I+++Q+  +   W+ G + G+ G FP N+V++
Sbjct:  425 TVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWWTGRYNGQQGVFPGNYVQL 479

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BLAST of Endophilin-A3 vs. Ensembl Yeast
Match: LSB1 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368])

HSP 1 Score: 46.9802 bits (110), Expect = 1.813e-6
Identity = 18/51 (35.29%), Postives = 31/51 (60.78%), Query Frame = 1

Query:  964 CRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVE 1116
              ALYDF A+   +L    GD I++++++  +W+ G+   K G FP N+V+
Sbjct:   58 VEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVK 108

[Close]

BLAST of Endophilin-A3 vs. Ensembl Nematostella
Match: EDO31161 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYP4])

HSP 1 Score: 261.536 bits (667), Expect = 5.677e-84
Identity = 150/357 (42.02%), Postives = 209/357 (58.54%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVL 1122
            M+FAG KKQ NKANQ +SEKIG  KG++L  E++E E+  D+   L +D+L KT EYLQPNPA R KL      HK+ G +     YPQ EG + ET  K   + G  ++FG++++E  +TF +L E K  L+  + QNF+ PLT+L   DI+EI  HR+K+QGRRL +D  KR   K NK+   D+  A++KFEE+K +  ++M N LD EAE I+ +S+  +A  DYH  AA++ +SL S L  +  EA+S  + + P     +      S    S+ S P           G   +      +ALYDF  E+  EL FS+GDII +   VDENW EG   G+TG FP N+VE +
Sbjct:    1 MSFAGFKKQINKANQYMSEKIGSAKGSQLEEEFVELERKTDSTAKLIEDVLHKTKEYLQPNPAARAKLSMQGAVHKVRG-EARSTRYPQPEGNLGETMVKGGQDLGDTSLFGQAMVEAGETFLQLAEVKDALDANVKQNFLDPLTQLENRDIKEIMQHRKKMQGRRLDYDCKKR---KSNKLPLEDIRIAEEKFEESKELCYNSMMNLLDGEAEQISQLSALSEAILDYHKHAAEVMQSLVSTLNDRVTEASSRPRSERPSFTPKFNDDDDSSSGGGSMPSLPTPTPSAPPPSSGGKEK-----VKALYDFEPENDGELGFSEGDIITIESTVDENWLEGSVHGRTGLFPRNYVESM 348

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BLAST of Endophilin-A3 vs. Ensembl Nematostella
Match: EDO47212 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMW0])

HSP 1 Score: 195.282 bits (495), Expect = 2.449e-58
Identity = 120/368 (32.61%), Postives = 189/368 (51.36%), Query Frame = 1

Query:   61 FAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG----GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQK-------RDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            FAG+KKQ NKANQ +SEK+G  +GT++  E++E E+  D    L  ++  KT EYLQPN  +  K+    T      +  EK  YP  EG + +       E G    G+ +  +L++ +    EL E ++ L++ +  NF+ PL  L  +D++E+  +R+K+QGRRL +D  KR   KGNKV+  ++  AQ KFEE+KN+    M   L +E + I  +   +    +YH ++ +  E   S+L ++       + EA +S   +AP             E  N       +P+      K  DS    P+C+A +D+ A+   EL F++G II L  + D+ W+EG   GK G FP   V++L  L
Sbjct:    5 FAGLKKQINKANQYVSEKMGSAEGTKMEDEFIEMERKTDALIELVANLTPKTKEYLQPNATYNAKVKMHMT------QPDEK--YPYTEGLMGDVMMLAGQEIGQVGKGSDYAAALLDFAGALHELAETRHELDEKVHSNFLGPLHDLEANDLKELTFNRKKLQGRRLDYDCKKR---KGNKVSIEEIKTAQFKFEESKNLCKQGMAKLLGNEMDMIEQLCQLVVDMLEYHKKSTESLEIAMSQLNKRIVNARRNQAEAEASAPKQAPE------------EPENVPEQHEKAPESTNPLAKSSDSDKLKPSCKAKFDYKAKKEGELSFTEGQIITLSGKRDDEWYEGTLDGKFGIFPSALVQILTDL 349

[Close]

BLAST of Endophilin-A3 vs. Ensembl Nematostella
Match: EDO38201 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDK8])

HSP 1 Score: 92.8189 bits (229), Expect = 6.927e-21
Identity = 85/357 (23.81%), Postives = 153/357 (42.86%), Query Frame = 1

Query:   82 FNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFH-KIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGN-----KVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKL-MQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKL--IQQVDENWFEGEFQGKTGFFPINFVEVL 1122
            F++A Q   E++G  + TE  + +    +  D  K   + +L +T   LQPNP  R    A + F+ K+  K  E+  + +  G+I E      NE G G  +G +L++   T K+L   +       + +++ PL    + D++ I+  RR +  +RL  D  K    K       +  +++L  AQ +F+    +    +D    S A H   + SFI+A+  Y+ Q     + L  +L      ++     P AP   +       G  D N+         +P + KK           + LYD+ A   +EL     ++I +  +  +D +W  GE   + G  P+ ++E+L
Sbjct:   19 FSRAKQYTEEQLGKAEATEFDARFESLLERADRTKQWTERLLKQTEALLQPNPGIR----AEEYFYSKLGEKKPERLTHLETLGKIME---DAGNELGPGTSYGSTLVKCGATEKKLASAERDFMTKSVSHYLHPLKSFLEGDMKTISTERRTLLAKRLDLDSCKAKVRKAQTPERIQQAESELRVAQAEFDRQYEVTKLLLDGIATSHANHHRALQSFIEAQAQYYAQCFQYMQDLQRQLGTPPPTDSVPLVPPTAPSAADVR-----GVLDVNAY-------PRPSVTKKA----------KVLYDYDATDSSELSLLSDEVITVYNVPGMDNDWMVGERGSQRGKVPVTYLELL 346

[Close]

BLAST of Endophilin-A3 vs. Ensembl Nematostella
Match: EDO44404 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVL2])

HSP 1 Score: 69.3218 bits (168), Expect = 1.153e-13
Identity = 30/64 (46.88%), Postives = 39/64 (60.94%), Query Frame = 1

Query:  940 DSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            D ++T P  R LYDF      +L    GD + L++QVDENWFEG+  G  GF P N+VEV+  L
Sbjct:   87 DQRTTKPCARVLYDFEPREQGDLALCKGDFVYLLRQVDENWFEGQVNGCQGFLPSNYVEVISAL 150

HSP 2 Score: 65.855 bits (159), Expect = 2.022e-12
Identity = 30/55 (54.55%), Postives = 37/55 (67.27%), Query Frame = 1

Query:  958 PTCRALYDF-AAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEV 1119
            P  +ALYDF   E  + L F  GD+I +I++VDENW EG+   K G FPINFVEV
Sbjct:  160 PVAKALYDFDGGEEQDILPFKQGDVISVIRKVDENWCEGKLNNKCGIFPINFVEV 214

[Close]

BLAST of Endophilin-A3 vs. Ensembl Nematostella
Match: EDO29864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2F6])

HSP 1 Score: 54.299 bits (129), Expect = 2.310e-9
Identity = 27/66 (40.91%), Postives = 40/66 (60.61%), Query Frame = 1

Query:  922 IFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEF--QGKTGFFPINFV 1113
            IF K  DS+ +  T  ALYDF A+   EL F  G+ I+++ + D+NW++G     G+ G FP N+V
Sbjct:   47 IFLKDVDSECSQDTVVALYDFVAQEAGELNFKKGNHIEVLDKEDDNWWKGRVAETGEEGLFPRNYV 112

[Close]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Match: ENSORLT00000037055.1 (endophilin-A1 [Source:NCBI gene;Acc:101160542])

HSP 1 Score: 263.462 bits (672), Expect = 2.777e-84
Identity = 145/363 (39.94%), Postives = 219/363 (60.33%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESG-GNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK---APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF+KA Q +SEK+GG +GT+L  ++ E EK +D       DI+ KTTEYLQPNPA R KL    T  KI G+D + P YPQ E  + +   K+  E G  + FG +L++  ++ KEL E K  L+  + QNFI PL  L   D++EI  H +K++GRRL FD     K++  KV D ++  A +KF+E+K IA  +M N L+S+ E ++ +++ ++A+ +YH +AA+I + L SK+  +  E +S  KP+   +P+   + +           ++S  +  + P    +        P CRALYDF  E+  EL F +GDII L  Q+D+NW+EG   G++GFFPIN+V++LVPL
Sbjct:    1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMEKKVDITSRAVLDIMTKTTEYLQPNPASRAKLSMINTMSKIRGQD-KGPGYPQAETILGDAMLKFGRELGEESSFGMALIDAGESIKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEIQHHLKKMEGRRLDFD---YKKKRQGKVQDEEIKQALEKFDESKEIAEQSMFNLLESDIEQVSQLAALVQAQLEYHSRAAEILQQLSSKMEDRIKEVSS--KPRKEYSPKPRMTLELLPPSESHNGGIHSAKSPGRSPAPMDQ--------PCCRALYDFEPENEGELGFKEGDIITLTNQIDDNWYEGMINGQSGFFPINYVDILVPL 349

[Close]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Match: sh3gl1b (endophilin-A2 [Source:NCBI gene;Acc:101164792])

HSP 1 Score: 261.536 bits (667), Expect = 1.568e-83
Identity = 141/360 (39.17%), Postives = 218/360 (60.56%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG+KKQF KA+Q++SEK+GG +GT+L  ++ + E+ +D       +++ KT+EYLQPNPA R KL    T  KI G+  + P YPQ EG + E  AKY  E G +  FG +L+++ ++ K L E K  L+  + QNFI PL  L   D+REI  H +K++GRRL +D     K++  K+ D ++  A +KF E+K++A  +M N L+++ E ++ +S+ + ++  YH QA  + E L  KL ++ +EA S  +P+            +G ++++S    P +   P         Q   P+C+ALYDF  E+  EL F +GD+I L  Q+DENW+EG   G++GFFP+N+VEVLVPL
Sbjct:    1 MSVAGLKKQFYKASQMVSEKVGGAEGTKLDDDFRDLERKVDVTSKAVAEVISKTSEYLQPNPASRAKLSMLNTMSKIRGQ-VKNPGYPQAEGLLGECMAKYGRELGEDTNFGGALVDVGESMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYD---YKKKRQGKIPDEEIRQALEKFHESKDVAETSMYNLLETDIEQVSQLSALVDSQLQYHRQAVQVLEELSDKLRERMNEAQS--RPRREYTPKPKPIFDFG-DNSHSNGGYPTTMAPPPSRNPAPPEQ---PSCKALYDFEPENEGELGFHEGDVITLTNQIDENWYEGMLNGQSGFFPLNYVEVLVPL 350

[Close]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Match: sh3gl1a (endophilin-A2 [Source:NCBI gene;Acc:101161753])

HSP 1 Score: 258.07 bits (658), Expect = 5.782e-82
Identity = 139/373 (37.27%), Postives = 219/373 (58.71%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTN-------------SLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG++KQ NKA Q+I+EK+GG +GT+L  ++ E E+  D       +++ KTTEYLQPNPA R KL    T  KI G+  + P YPQ EG + E   KY  + G +  FG +L+++ +T K + E K  L+  + QNFI PL  +   DI++I  H +K++GRRL +D     K++  K+ D +L  A +KF E++++A  +M N L+++ E ++ +S+F+ +   YH +A  I + L  +L ++  +A S  K + P+            +D+N             S  +Q  S ++P + KK  D     P C+A+YDF  E+  EL F +GDII L+ ++DENW+EG  QG++G+FP N+VEV+VPL
Sbjct:    1 MSVAGLRKQINKATQMINEKVGGAEGTKLDEDFKELERKADITSKAMLEVISKTTEYLQPNPATRAKLTMLNTVSKIRGQ-VKSPGYPQPEGLLGEAMLKYGRDMGDDTNFGGALLDVGETMKRMAEVKDSLDIDVKQNFIDPLQAVADKDIKDIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQALEKFHESRDLAETSMYNLLETDVEQVSQLSAFVDSLLQYHQEATQILQELNGRLKERVSDAQSRPKREIPKKRQESFEYGHEQDDSNGGYSPAAINPPSYSAAAQYPSFQRPSVKKKPTD-----PCCKAMYDFEPENDGELGFREGDIITLVSKIDENWYEGRLQGRSGYFPTNYVEVMVPL 364

[Close]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Match: sh3gl1a (endophilin-A2 [Source:NCBI gene;Acc:101161753])

HSP 1 Score: 256.529 bits (654), Expect = 1.523e-81
Identity = 134/360 (37.22%), Postives = 215/360 (59.72%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            M+ AG++KQ NKA Q+I+EK+GG +GT+L  ++ E E+  D       +++ KTTEYLQPNPA R KL    T  KI G+  + P YPQ EG + E   KY  + G +  FG +L+++ +T K + E K  L+  + QNFI PL  +   DI++I  H +K++GRRL +D     K++  K+ D +L  A +KF E++++A  +M N L+++ E ++ +S+F+ +   YH +A  I + L  +L ++  +A S  K + P+     ++  +G E  +S      +   P  +       +  P C+A+YDF  E+  EL F +GDII L+ ++DENW+EG  QG++G+FP N+VEV+VPL
Sbjct:    1 MSVAGLRKQINKATQMINEKVGGAEGTKLDEDFKELERKADITSKAMLEVISKTTEYLQPNPATRAKLTMLNTVSKIRGQ-VKSPGYPQPEGLLGEAMLKYGRDMGDDTNFGGALLDVGETMKRMAEVKDSLDIDVKQNFIDPLQAVADKDIKDIQHHLKKLEGRRLDYD---YKKKRQGKIPDEELRQALEKFHESRDLAETSMYNLLETDVEQVSQLSAFVDSLLQYHQEATQILQELNGRLKERVSDAQSRPKREIPKKRQ--ESFEYGHEQDDSNGGYSPAAINPPSYS------AADPCCKAMYDFEPENDGELGFREGDIITLVSKIDENWYEGRLQGRSGYFPTNYVEVMVPL 348

[Close]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Match: ENSORLT00000025093.2 (endophilin-A1 [Source:NCBI gene;Acc:101160542])

HSP 1 Score: 246.899 bits (629), Expect = 6.917e-78
Identity = 139/359 (38.72%), Postives = 212/359 (59.05%), Query Frame = 1

Query:   67 GIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGG-NVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPK---APRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPL 1131
            G+  QF+  +  +SEK+GG +GT+L  ++ E EK +D       DI+ KTTEYLQPNPA R KL    T  KI G+D + P YPQ E  + +   K+  E G  + FG +L++  ++ KEL E K  L+  + QNFI PL  L   D++EI  H +K++GRRL FD     K++  KV D ++  A +KF+E+K IA  +M N L+S+ E ++ +++ ++A+ +YH +AA+I + L SK M+ R  +  S KP+   +P+   + +           ++S  +  + P    +        P CRALYDF  E+  EL F +GDII L  Q+D+NW+EG   G++GFFPIN+V++LVPL
Sbjct:    5 GLSGQFHTGSS-VSEKVGGAEGTKLDDDFKEMEKKVDITSRAVLDIMTKTTEYLQPNPASRAKLSMINTMSKIRGQD-KGPGYPQAETILGDAMLKFGRELGEESSFGMALIDAGESIKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEIQHHLKKMEGRRLDFD---YKKKRQGKVQDEEIKQALEKFDESKEIAEQSMFNLLESDIEQVSQLAALVQAQLEYHSRAAEILQQLSSK-MEDRYRSALSSKPRKEYSPKPRMTLELLPPSESHNGGIHSAKSPGRSPAPMDQ--------PCCRALYDFEPENEGELGFKEGDIITLTNQIDDNWYEGMINGQSGFFPINYVDILVPL 349

[Close]

BLAST of Endophilin-A3 vs. Planmine SMEST
Match: SMESG000061276.1 (SMESG000061276.1)

HSP 1 Score: 740.725 bits (1911), Expect = 0.000e+0
Identity = 360/361 (99.72%), Postives = 360/361 (99.72%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLRD 1137
            MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQ TIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLRD
Sbjct:    1 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQLTIPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLRD 361

[Close]

BLAST of Endophilin-A3 vs. Planmine SMEST
Match: SMESG000043383.1 (SMESG000043383.1)

HSP 1 Score: 397.127 bits (1019), Expect = 1.985e-136
Identity = 195/366 (53.28%), Postives = 269/366 (73.50%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQ--PYIFKKGYD-SQST--IPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLRD 1137
            M+  G+KKQ NKANQLI+EK+G  KGTEL  +Y+E EK ID  K+LFD++L K TEYLQPNP++R KL     FHKI+GK  +K LYPQ E QISE F KY  E     FG  LME S++FK++ + KY LED I QNF+ P++K++++D++EI  HR+KVQGRRL +D  KRNKEKG+K+++ ++  A++KFE++K++A +AM+NFLDSE EHIN ++ FIKAE +YH + A+I ESLY+ +++K +E   S K  A + ++S K  S+   D +S NS+ ++ +Q      K  +D SQST  +PTCRALYDF AES  ELQF++GD+IKL+QQVD++WFEGE   + GFFPIN+VEVL+PL +
Sbjct:    1 MSLTGLKKQLNKANQLINEKVGAAKGTELEEDYIETEKKIDLCKNLFDELLNKITEYLQPNPSYRAKLTTMNAFHKISGKTNQKALYPQPENQISEIFNKYGKELKSTTFGSCLMETSESFKDMADIKYSLEDQIKQNFVEPISKIQETDMKEIMHHRKKVQGRRLDYDCKKRNKEKGSKISEDEVKAAEEKFEDSKSLAIEAMNNFLDSEGEHINALAEFIKAEMEYHSRTAEILESLYNSIIEKSEEC--SNKAPASQRISSLKKCSYS--DNHSSNSETDNSEQLVKLTIKTKHDTSQSTQRVPTCRALYDFKAESEAELQFNEGDVIKLLQQVDDSWFEGEHNNRKGFFPINYVEVLIPLSE 362

[Close]

BLAST of Endophilin-A3 vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1)

HSP 1 Score: 323.939 bits (829), Expect = 8.833e-108
Identity = 170/367 (46.32%), Postives = 240/367 (65.40%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G+KKQFNKANQLISEKIGG KGTEL SE+L+ EK ID    L ++++ +T E++QPNPA R +L+   T HK +GK G+  LYPQ EG + E   KY  + G +  FG++L+E  D F+++ E KY LED I QNF+ P + L+  ++REIN HR+K++GRRL FD  KR ++KG K+ D ++  A+ KFEE+K++A  AM NFL SE EHI  + SFI+++ +YH +A  + + L + L  K D+A    KPK P+ +    T+S    + N +N    S     +FK       T       P  R L+DF AE+  EL F +G+I+KLIQQVDENWFEGE  G+ G+FP+N+VE++VPL+
Sbjct:    1 MSLSGLKKQFNKANQLISEKIGGAKGTELDSEFLDYEKKIDILGKLIEEMIARTHEFMQPNPATRARLMTMNTLHKFSGK-GKSSLYPQPEGLLGECMMKYGKDLGDDSQFGEALIETGDVFRQMAEIKYQLEDNIKQNFLEPFSNLQIRELREINHHRKKLEGRRLDFDCKKRKQDKGAKILDEEIKTAEDKFEESKSLAELAMTNFLSSEVEHIQALQSFIQSQMEYHAEANKLLQELNNLLTVKSDKAKL--KPK-PQPMPKRSTSSRSLYEENPVNDAALSGNS--LFKSNTSQYPTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYVEIIVPLK 361

[Close]

BLAST of Endophilin-A3 vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1)

HSP 1 Score: 323.553 bits (828), Expect = 4.179e-107
Identity = 170/367 (46.32%), Postives = 240/367 (65.40%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G+KKQFNKANQLISEKIGG KGTEL SE+L+ EK ID    L ++++ +T E++QPNPA R +L+   T HK +GK G+  LYPQ EG + E   KY  + G +  FG++L+E  D F+++ E KY LED I QNF+ P + L+  ++REIN HR+K++GRRL FD  KR ++KG K+ D ++  A+ KFEE+K++A  AM NFL SE EHI  + SFI+++ +YH +A  + + L + L  K D+A    KPK P+ +    T+S    + N +N    S     +FK       T       P  R L+DF AE+  EL F +G+I+KLIQQVDENWFEGE  G+ G+FP+N+VE++VPL+
Sbjct:    1 MSLSGLKKQFNKANQLISEKIGGAKGTELDSEFLDYEKKIDILGKLIEEMIARTHEFMQPNPATRARLMTMNTLHKFSGK-GKSSLYPQPEGLLGECMMKYGKDLGDDSQFGEALIETGDVFRQMAEIKYQLEDNIKQNFLEPFSNLQIRELREINHHRKKLEGRRLDFDCKKRKQDKGAKILDEEIKTAEDKFEESKSLAELAMTNFLSSEVEHIQALQSFIQSQMEYHAEANKLLQELNNLLTVKSDKAKL--KPK-PQPMPKRSTSSRSLYEENPVNDAALSGNS--LFKSNTSQYPTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYVEIIVPLK 361

[Close]

BLAST of Endophilin-A3 vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1)

HSP 1 Score: 322.783 bits (826), Expect = 2.204e-105
Identity = 170/367 (46.32%), Postives = 240/367 (65.40%), Query Frame = 1

Query:   55 MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDILLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAKYSNESGGNV-FGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSDIREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIASDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEANSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQSTI------PTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPINFVEVLVPLR 1134
            M+ +G+KKQFNKANQLISEKIGG KGTEL SE+L+ EK ID    L ++++ +T E++QPNPA R +L+   T HK +GK G+  LYPQ EG + E   KY  + G +  FG++L+E  D F+++ E KY LED I QNF+ P + L+  ++REIN HR+K++GRRL FD  KR ++KG K+ D ++  A+ KFEE+K++A  AM NFL SE EHI  + SFI+++ +YH +A  + + L + L  K D+A    KPK P+ +    T+S    + N +N    S     +FK       T       P  R L+DF AE+  EL F +G+I+KLIQQVDENWFEGE  G+ G+FP+N+VE++VPL+
Sbjct:    1 MSLSGLKKQFNKANQLISEKIGGAKGTELDSEFLDYEKKIDILGKLIEEMIARTHEFMQPNPATRARLMTMNTLHKFSGK-GKSSLYPQPEGLLGECMMKYGKDLGDDSQFGEALIETGDVFRQMAEIKYQLEDNIKQNFLEPFSNLQIRELREINHHRKKLEGRRLDFDCKKRKQDKGAKILDEEIKTAEDKFEESKSLAELAMTNFLSSEVEHIQALQSFIQSQMEYHAEANKLLQELNNLLTVKSDKAKL--KPK-PQPMPKRSTSSRSLYEENPVNDAALSGNS--LFKSNTSQYPTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYVEIIVPLK 361

The following BLAST results are available for this feature:

BLAST of Endophilin-A3 vs. Ensembl Human
BLAST of Endophilin-A3 vs. Ensembl Celegans
BLAST of Endophilin-A3 vs. Ensembl Fly
BLAST of Endophilin-A3 vs. Ensembl Zebrafish
BLAST of Endophilin-A3 vs. Ensembl Xenopus
BLAST of Endophilin-A3 vs. Ensembl Mouse
BLAST of Endophilin-A3 vs. UniProt/SwissProt
BLAST of Endophilin-A3 vs. TrEMBL
BLAST of Endophilin-A3 vs. Ensembl Cavefish
BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
BLAST of Endophilin-A3 vs. Ensembl Yeast
BLAST of Endophilin-A3 vs. Ensembl Nematostella
BLAST of Endophilin-A3 vs. Ensembl Medaka
BLAST of Endophilin-A3 vs. Planmine SMEST

BLAST of Endophilin-A3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SH3GL3	1.177e-85	41.67	SH3 domain containing GRB2 like 3, endophilin A3 [...	[more]
SH3GL1	2.839e-85	39.73	SH3 domain containing GRB2 like 1, endophilin A2 [...	[more]
SH3GL2	2.332e-84	40.17	SH3 domain containing GRB2 like 2, endophilin A1 [...	[more]
SH3GL3	1.543e-78	40.44	SH3 domain containing GRB2 like 3, endophilin A3 [...	[more]
SH3GL1	4.443e-67	34.69	SH3 domain containing GRB2 like 1, endophilin A2 [...	[more]

BLAST of Endophilin-A3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
unc-57	1.025e-82	36.81	Endophilin-A homolog [Source:UniProtKB/Swiss-Prot...	[more]
unc-57	2.436e-82	36.62	Endophilin-A homolog [Source:UniProtKB/Swiss-Prot...	[more]
unc-57	2.412e-81	36.69	Endophilin-A homolog [Source:UniProtKB/Swiss-Prot...	[more]
unc-57	2.799e-20	56.25	Endophilin-A homolog [Source:UniProtKB/Swiss-Prot...	[more]
sorb-1	4.922e-9	39.68	SORBin homolog [Source:UniProtKB/TrEMBL;Acc:O6248...	[more]

BLAST of Endophilin-A3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
EndoA	1.007e-78	38.01	gene:FBgn0038659 transcript:FBtr0083699	[more]
EndoA	1.007e-78	38.01	gene:FBgn0038659 transcript:FBtr0334522	[more]
EndoA	1.007e-78	38.01	gene:FBgn0038659 transcript:FBtr0083698	[more]
POSH	1.348e-10	45.76	gene:FBgn0040294 transcript:FBtr0086828	[more]
Asap	5.718e-10	37.23	gene:FBgn0050372 transcript:FBtr0300954	[more]

BLAST of Endophilin-A3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sh3gl1a	4.653e-84	37.85	SH3-domain GRB2-like 1a [Source:ZFIN;Acc:ZDB-GENE-...	[more]
sh3gl1b	1.906e-83	40.00	SH3-domain GRB2-like 1b [Source:ZFIN;Acc:ZDB-GENE-...	[more]
sh3gl1a	1.402e-82	37.90	SH3-domain GRB2-like 1a [Source:ZFIN;Acc:ZDB-GENE-...	[more]
sh3gl1b	2.777e-82	39.19	SH3-domain GRB2-like 1b [Source:ZFIN;Acc:ZDB-GENE-...	[more]
sh3gl2a	1.578e-80	39.72	SH3 domain containing GRB2 like 2a, endophilin A1 ...	[more]

BLAST of Endophilin-A3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sh3gl1	2.093e-86	41.83	SH3-domain GRB2-like 1 [Source:NCBI gene;Acc:61936...	[more]
gipc2	3.223e-84	40.83	GIPC PDZ domain containing family member 2 [Source...	[more]
sh3gl2	7.733e-84	41.39	SH3-domain GRB2-like 2 [Source:NCBI gene;Acc:10003...	[more]
sh3gl1	2.665e-82	39.73	SH3-domain GRB2-like 1 [Source:NCBI gene;Acc:61936...	[more]
gipc2	1.265e-76	39.88	GIPC PDZ domain containing family member 2 [Source...	[more]

BLAST of Endophilin-A3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Sh3gl2	4.011e-87	40.72	SH3-domain GRB2-like 2 [Source:MGI Symbol;Acc:MGI:...	[more]
Sh3gl3	4.170e-87	42.50	SH3-domain GRB2-like 3 [Source:MGI Symbol;Acc:MGI:...	[more]
Sh3gl1	2.903e-84	39.19	SH3-domain GRB2-like 1 [Source:MGI Symbol;Acc:MGI:...	[more]
Sh3gl3	9.633e-72	40.74	SH3-domain GRB2-like 3 [Source:MGI Symbol;Acc:MGI:...	[more]
Sh3gl2	2.407e-71	39.05	SH3-domain GRB2-like 2 [Source:MGI Symbol;Acc:MGI:...	[more]

BLAST of Endophilin-A3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q62420\|SH3G2_MOUSE	2.806e-86	40.72	Endophilin-A1 OS=Mus musculus OX=10090 GN=Sh3gl2 P...	[more]
sp\|Q62421\|SH3G3_MOUSE	6.910e-86	42.22	Endophilin-A3 OS=Mus musculus OX=10090 GN=Sh3gl3 P...	[more]
sp\|O35180\|SH3G3_RAT	3.712e-85	41.60	Endophilin-A3 OS=Rattus norvegicus OX=10116 GN=Sh3...	[more]
sp\|Q8AXV0\|SH3G1_CHICK	3.877e-85	40.43	Endophilin-A2 OS=Gallus gallus OX=9031 GN=SH3GL1 P...	[more]
sp\|Q99963\|SH3G3_HUMAN	5.651e-85	41.67	Endophilin-A3 OS=Homo sapiens OX=9606 GN=SH3GL3 PE...	[more]

BLAST of Endophilin-A3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3K9F9	4.823e-103	44.99	endophilin-A3 isoform X3 OS=Lingula unguis OX=7574...	[more]
W6USB0	1.229e-101	45.60	Endophilin-A3 OS=Echinococcus granulosus OX=6210 G...	[more]
A0A1S3K928	8.651e-101	44.50	endophilin-A3 isoform X2 OS=Lingula unguis OX=7574...	[more]
A0A4S2LB47	1.991e-100	44.47	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
A0A0X3PT28	3.616e-100	43.96	Uncharacterized protein OS=Schistocephalus solidus...	[more]

BLAST of Endophilin-A3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000053701.1	5.820e-88	41.83	endophilin-A1 [Source:NCBI gene;Acc:103033999]	[more]
sh3gl3a	3.422e-82	39.89	endophilin-A3-like [Source:NCBI gene;Acc:103022507...	[more]
sh3gl1b	3.985e-82	39.36	SH3 domain containing GRB2 like 1, endophilin A2 [...	[more]
sh3gl3a	2.784e-81	40.16	endophilin-A3-like [Source:NCBI gene;Acc:103022507...	[more]
sh3gl3a	5.674e-81	38.44	endophilin-A3-like [Source:NCBI gene;Acc:103022507...	[more]

BLAST of Endophilin-A3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SH3GL1	1.683e-72	35.90	SH3 domain containing GRB2 like 1, endophilin A2 [...	[more]
SH3GL1	1.217e-25	37.75	SH3 domain containing GRB2 like 1, endophilin A2 [...	[more]
SH3GLB2	1.224e-13	22.16	SH3 domain containing GRB2 like, endophilin B2 [So...	[more]
sorbs1	3.061e-11	41.54	sorbin and SH3 domain containing 1 [Source:ZFIN;Ac...	[more]
nebl	3.912e-10	44.44	nebulette [Source:ZFIN;Acc:ZDB-GENE-050320-151]	[more]

BLAST of Endophilin-A3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
HSE1	4.341e-12	39.34	Subunit of the endosomal Vps27p-Hse1p complex; com...	[more]
YSC84	8.721e-11	42.62	Actin-binding protein; involved in bundling of act...	[more]
LSB3	2.357e-8	38.60	Protein containing a C-terminal SH3 domain; binds ...	[more]
RVS167	7.609e-7	34.55	Calmodulin-binding actin-associated protein; roles...	[more]
LSB1	1.813e-6	35.29	Negative regulator of actin nucleation-promoting f...	[more]

BLAST of Endophilin-A3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO31161	5.677e-84	42.02	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47212	2.449e-58	32.61	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38201	6.927e-21	23.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44404	1.153e-13	46.88	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29864	2.310e-9	40.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Endophilin-A3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000037055.1	2.777e-84	39.94	endophilin-A1 [Source:NCBI gene;Acc:101160542]	[more]
sh3gl1b	1.568e-83	39.17	endophilin-A2 [Source:NCBI gene;Acc:101164792]	[more]
sh3gl1a	5.782e-82	37.27	endophilin-A2 [Source:NCBI gene;Acc:101161753]	[more]
sh3gl1a	1.523e-81	37.22	endophilin-A2 [Source:NCBI gene;Acc:101161753]	[more]
ENSORLT00000025093.2	6.917e-78	38.72	endophilin-A1 [Source:NCBI gene;Acc:101160542]	[more]

BLAST of Endophilin-A3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000061276.1	0.000e+0	99.72	SMESG000061276.1	[more]
SMESG000043383.1	1.985e-136	53.28	SMESG000043383.1	[more]
SMESG000022674.1	8.833e-108	46.32	SMESG000022674.1	[more]
SMESG000022674.1	4.179e-107	46.32	SMESG000022674.1	[more]
SMESG000022674.1	2.204e-105	46.32	SMESG000022674.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30014810 ID=SMED30014810|Name=Endophilin-A3|organism=Schmidtea mediterranea sexual|type=transcript|length=1367bp
TTCAAAGATTTAAATAATTTAAAGTTTTTCAATTGATAATTTTCAAATAT
TGGAATGGCTTTTGCTGGAATTAAAAAACAATTTAATAAAGCTAATCAGC
TTATTTCAGAAAAAATTGGAGGTGTTAAAGGGACCGAGTTAAGTAGTGAA
TATTTAGAAAATGAAAAGTTAATAGATAATTACAAACATTTATTTGATGA
TATATTATTAAAAACTACTGAATATTTGCAACCTAATCCTGCTCATCGAA
CAAAATTATTGGCTGCGAAAACATTTCACAAAATAGCTGGTAAAGATGGT
GAAAAACCGCTTTATCCACAAATCGAAGGACAGATATCTGAGACATTTGC
AAAATACTCAAATGAATCAGGTGGAAATGTTTTCGGAAAGTCATTAATGG
AGATCAGTGATACTTTTAAGGAATTAGAGGAAAAAAAATATGGATTAGAA
GATACAATAATGCAAAATTTCATCAGTCCACTAACGAAATTACGTCAAAG
TGACATTAGAGAAATTAATTTACACAGAAGAAAGGTTCAAGGTCGACGAT
TGACGTTCGATGGATTGAAAAGAAACAAAGAAAAAGGGAATAAAGTAACA
GACGCTGATTTGGACGATGCACAAAAGAAATTCGAAGAAGCAAAAAATAT
TGCTTCTGATGCTATGGATAACTTTTTAGATTCAGAAGCTGAACATATCA
ATATTATATCATCCTTCATTAAAGCTGAAAGAGATTACCATCATCAGGCT
GCTGATATTTTTGAGTCCCTATATTCCAAATTAATGCAAAAGCGCGATGA
AGCTAATTCATCAGAAAAACCCAAAGCACCCAGGAATGTTAATAGTTATA
AAACCGCAAGCTGGGGCAGTGAGGATACGAACAGTTTGAACAGCCAACCA
AACAGTCCGAAACAACCGTACATTTTCAAGAAAGGATATGATTCACAATC
AACTATTCCTACTTGTCGAGCTTTATATGATTTTGCTGCGGAATCTCCGA
ATGAACTTCAGTTTTCTGACGGGGATATCATTAAACTTATTCAACAAGTT
GATGAAAACTGGTTTGAGGGAGAATTTCAAGGTAAAACGGGATTTTTCCC
CATAAACTTTGTGGAGGTCTTGGTGCCTTTAAGAGATTAAATTCAATTTT
TCAAATCATTTTCTTTGATTTCTATTTGTGATATGTATTTTGATGTTTTG
TGTTTTCTTTTTCTACTTTGCTGGTGACAAAACGTGCATACACTTTTTGT
ACTGCAGGCGTAGATGCTGAACATAACTAGCGATATTGCTCATCACAATA
TTTATTATCAACCGATATTTTCAATACTATATATTAATTATTTTCTAATA
GATGATTTACGCTAGAA

protein sequence of SMED30014810-orf-1

>SMED30014810-orf-1 ID=SMED30014810-orf-1|Name=SMED30014810-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=362bp
MAFAGIKKQFNKANQLISEKIGGVKGTELSSEYLENEKLIDNYKHLFDDI
LLKTTEYLQPNPAHRTKLLAAKTFHKIAGKDGEKPLYPQIEGQISETFAK
YSNESGGNVFGKSLMEISDTFKELEEKKYGLEDTIMQNFISPLTKLRQSD
IREINLHRRKVQGRRLTFDGLKRNKEKGNKVTDADLDDAQKKFEEAKNIA
SDAMDNFLDSEAEHINIISSFIKAERDYHHQAADIFESLYSKLMQKRDEA
NSSEKPKAPRNVNSYKTASWGSEDTNSLNSQPNSPKQPYIFKKGYDSQST
IPTCRALYDFAAESPNELQFSDGDIIKLIQQVDENWFEGEFQGKTGFFPI
NFVEVLVPLRD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000018	Category 4 cell
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR028501	Endophilin-A
IPR036028	SH3-like_dom_sf
IPR001452	SH3_domain
IPR004148	BAR_dom
IPR027267	AH/BAR_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0006897	endocytosis

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 186..206
None	No IPR available	PRINTS	PR00499	P67PHOX	coord: 324..340 score: 45.59 coord: 304..324 score: 33.33 coord: 340..353 score: 51.79
None	No IPR available	GENE3D	G3DSA:2.30.30.40		coord: 292..361 e-value: 2.6E-25 score: 89.7
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 256..285
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 247..285
None	No IPR available	PANTHER	PTHR14167	SH3 DOMAIN-CONTAINING	coord: 3..359
IPR001452	SH3 domain	PRINTS	PR00452	SH3DOMAIN	coord: 333..342 score: 27.0 coord: 344..356 score: 41.72 coord: 316..331 score: 31.57 coord: 302..312 score: 43.47
IPR001452	SH3 domain	SMART	SM00326	SH3_2	coord: 302..357 e-value: 7.6E-21 score: 85.3
IPR001452	SH3 domain	PFAM	PF00018	SH3_1	coord: 305..349 e-value: 9.6E-15 score: 53.9
IPR001452	SH3 domain	PROSITE	PS50002	SH3	coord: 299..358 score: 26.139
IPR004148	BAR domain	SMART	SM00721	5bar	coord: 5..245 e-value: 6.0E-45 score: 165.3
IPR004148	BAR domain	PFAM	PF03114	BAR	coord: 6..243 e-value: 2.2E-49 score: 168.3
IPR004148	BAR domain	PROSITE	PS51021	BAR	coord: 18..252 score: 22.38
IPR027267	AH/BAR domain superfamily	GENE3D	G3DSA:1.20.1270.60		coord: 1..249 e-value: 1.6E-63 score: 217.0
IPR027267	AH/BAR domain superfamily	SUPERFAMILY	SSF103657	BAR/IMD domain-like	coord: 11..243
IPR028501	Endophilin-A	PANTHER	PTHR14167:SF45	ENDOPHILIN-A3	coord: 3..359
IPR036028	SH3-like domain superfamily	SUPERFAMILY	SSF50044	SH3-domain	coord: 299..357