cGMP-dependent protein kinase

Overview


Name	cGMP-dependent protein kinase
Smed ID	SMED30014787
Length (bp)	2801

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of cGMP-dependent protein kinase (SMED30014787) t-SNE clustered cells

Violin plots show distribution of expression levels for cGMP-dependent protein kinase (SMED30014787) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cGMP-dependent protein kinase (SMED30014787) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for cGMP-dependent protein kinase (SMED30014787) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30014787

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30014787	SMESG000016927.1	dd_Smed_v4_27739_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30014787	SMESG000016927.1	dd_Smed_v4_27739_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
anterior side	SMED30014787	SMESG000016927.1	dd_Smed_v4_27739_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30014787	SMESG000016927.1	dd_Smed_v4_27739_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30014787	SMESG000016927.1	dd_Smed_v4_27739_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
pharynx	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
anterior side	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
dorsal ventral margin of the whole animal	SMED30014787	SMESG000016927.1	dd_Smed_v4_7139_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 806.979 bits (2083), Expect = 0.000e+0
Identity = 395/621 (63.61%), Postives = 477/621 (76.81%), Query Frame = 2

Query:  662 RMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
            R KR AIS E   F     S   LP++ K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P +  E PPDD SGWD DF
Sbjct:   73 RTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 797.349 bits (2058), Expect = 0.000e+0
Identity = 391/616 (63.47%), Postives = 473/616 (76.79%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLKT---KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K+   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P +  E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 630.172 bits (1624), Expect = 0.000e+0
Identity = 330/691 (47.76%), Postives = 452/691 (65.41%), Query Frame = 2

Query:  539 LNSSQNNQVLCYNCGAKLQLAYIYTDIEENNK-NGDFKLSNERMKRIAISGESGTFISSPEVLPYF-------EKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDL--------PKEILGPSKEYKNLAL------------------KDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            LN  Q+  V+    G+ LQ +     +E + K +G   L + R  +  +S E  T        P F        K    K+LI  ++ +N F+K L+  QIK +V+CM    +   S IIK+GE G+ ++V+ +G++ V +    L  +   T FGELAILYNCTRTA+V AIT+ K WA+DR  FQ+IM RT   + E+  NFL+SV + K+L E  L KI   LE  +Y  GDYIIR+G +G TFFI++ GKV+VT+  +  D   + Q I+ +Q+GE+FGEKAL  +D+R+ANIIA +   V CLV+DRE++ Q +G    LQ+  E  V +L         K  +   K  K L+L                  ++L +IATLG+GGFGRVELV++  N    +A+K ++K HIV+T+QQEH+ +E+ IL  + S FIV+L+RTFKD K++YML+E CLGGELWSILRDR +FDE T+KF  ACV EA  YLH  GI+YRDLKPENL+LD +G+ K+ DFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD   D WSLGIL++ELLTG PPF+  D M  YN+ILKGI+ ++FP+KI++  ++LI++LCR NP ER+G  K G+ + +KH WL  FNW+GL + ++  P+  ++  P D S FD+YPPE  MPPD++SGWD+DF
Sbjct:   79 LNKLQD--VVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD---QPQLIKTLQKGEYFGEKALISDDVRSANIIAEE-NDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762

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Query:  539 LNSSQNNQVLCYNCGAKLQLAYIYTDIEENNK-NGDFKLSNERMKRIAISGESGTFISSPEVLPYF-------EKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDL--------PKEILGPSKEYKNLAL------------------KDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            LN  Q+  V+    G+ LQ +     +E + K +G   L + R  +  +S E  T        P F        K    K+LI  ++ +N F+K L+  QIK +V+CM    +   S IIK+GE G+ ++V+ +G++ V +    L  +   T FGELAILYNCTRTA+V AIT+ K WA+DR  FQ+IM RT   + E+  NFL+SV + K+L E  L KI   LE  +Y  GDYIIR+G +G TFFI++ GKV+VT+  +  D   + Q I+ +Q+GE+FGEKAL  +D+R+ANIIA +   V CLV+DRE++ Q +G    LQ+  E  V +L         K  +   K  K L+L                  ++L +IATLG+GGFGRVELV++  N    +A+K ++K HIV+T+QQEH+ +E+ IL  + S FIV+L+RTFKD K++YML+E CLGGELWSILRDR +FDE T+KF  ACV EA  YLH  GI+YRDLKPENL+LD +G+ K+ DFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD   D WSLGIL++ELLTG PPF+  D M  YN+ILKGI+ ++FP+KI++  ++LI++LCR NP ER+G  K G+ + +KH WL  FNW+GL + ++  P+  ++  P D S FD+YPPE  MPPD++SGWD+DF
Sbjct:   79 LNKLQD--VVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD---QPQLIKTLQKGEYFGEKALISDDVRSANIIAEE-NDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 609.757 bits (1571), Expect = 0.000e+0
Identity = 315/670 (47.01%), Postives = 441/670 (65.82%), Query Frame = 2

Query:  539 LNSSQNNQVLCYNCGAKLQLAYIYTDIEENNK-NGDFKLSNERMKRIAISGESGTFISSPEVLPYF-------EKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKK-----TYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            LN  Q+  V+    G+ LQ +     +E + K +G   L + R  +  +S E  T        P F        K    K+LI  ++ +N F+K L+  QIK +V+CM    +   S IIK+GE G+ ++V+ +G++ V +    L  +   T FGELAILYNCTRTA+V AIT+ K WA+DR  FQ+IM RT   + E+  NFL+SV + K+L E  L KI   LE  +Y  GDYIIR+G +G TFFI++ GKV+VT+  +  D   + Q I+ +Q+GE+FGEKAL  +D+R+ANIIA +   V CLV+DRE++ Q +G    LQ+  E  V +L ++     K +   ++ +  +   L +      E++Q+ + VK       +A+K ++K HIV+T+QQEH+ +E+ IL  + S FIV+L+RTFKD K++YML+E CLGGELWSILRDR +FDE T+KF  ACV EA  YLH  GI+YRDLKPENL+LD +G+ K+ DFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD   D WSLGIL++ELLTG PPF+  D M  YN+ILKGI+ ++FP+KI++  ++LI++LCR NP ER+G  K G+ + +KH WL  FNW+GL + ++  P+  ++  P D S FD+YPPE  MPPD++SGWD+DF
Sbjct:   79 LNKLQD--VVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD---QPQLIKTLQKGEYFGEKALISDDVRSANIIAEE-NDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRD---DEKRHAKRSMSNWKLSKALSL------EMIQLKEKVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 733

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BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 695.271 bits (1793), Expect = 0.000e+0
Identity = 329/627 (52.47%), Postives = 455/627 (72.57%), Query Frame = 2

Query:  659 ERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDG--VNDLPKEILGPSK-------EYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFP-KKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R K+IA+S E   F + P  L ++ K +  K++I+ ++ +NDF+K L + QI  +V+CM  ++  A   +I+EGE G  ++V+ +G++ VS+EG  L +M+  TV GELAILYNCTRTA+V A+TD +LW +DR  FQ I  R G+ ++ + +NFL  V IF++L E  + K++ V+++ +Y  G YIIRQG KGD FF+I+SG+V+VT++ +  +T  +E  IR + +G++FGE+AL  E++RTANIIA  P GV+ L LDRES+ +LIGDL SL++ Y D   +  + +E   P K       E+  + LK++  +ATLG+GGFGRVELV +  +  KT+ALK LKK HIV+TRQQEHI  ERNI+    +D+IV+L++TF+D+KF+YML+EVCLGGELW+ LRDR  FD+ T +FY ACV+E L YLH + IVYRDLKPEN LL N G+ K+ DFGFAKK+  GRKTWTFCGTPEYV+PEIILNKGHD  AD W+LGI + EL+ G PPF A DPMK Y +ILKG+DA+E P ++I K A  L+KKLCRDNP ER+G G GGV + +KH W   F+W+GL S T+KPPI+P++++P D +NFD YPP+ ++PPD+ SGWD  F
Sbjct:  127 QRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE-GETEPRE--IRVLNQGDFFGERALLGEEVRTANIIAQAP-GVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

[Close]

Query:  659 ERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDG--VNDLPKEILGPSK-------EYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFP-KKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R K+IA+S E   F + P  L ++ K +  K++I+ ++ +NDF+K L + QI  +V+CM  ++  A   +I+EGE G  ++V+ +G++ VS+EG  L +M+  TV GELAILYNCTRTA+V A+TD +LW +DR  FQ I  R G+ ++ + +NFL  V IF++L E  + K++ V+++ +Y  G YIIRQG KGD FF+I+SG+V+VT++ +  +T  +E  IR + +G++FGE+AL  E++RTANIIA  P GV+ L LDRES+ +LIGDL SL++ Y D   +  + +E   P K       E+  + LK++  +ATLG+GGFGRVELV +  +  KT+ALK LKK HIV+TRQQEHI  ERNI+    +D+IV+L++TF+D+KF+YML+EVCLGGELW+ LRDR  FD+ T +FY ACV+E L YLH + IVYRDLKPEN LL N G+ K+ DFGFAKK+  GRKTWTFCGTPEYV+PEIILNKGHD  AD W+LGI + EL+ G PPF A DPMK Y +ILKG+DA+E P ++I K A  L+KKLCRDNP ER+G G GGV + +KH W   F+W+GL S T+KPPI+P++++P D +NFD YPP+ ++PPD+ SGWD  F
Sbjct:  127 QRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE-GETEPRE--IRVLNQGDFFGERALLGEEVRTANIIAQAP-GVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

[Close]

Query:  659 ERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDG--VNDLPKEILGPSK-------EYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFP-KKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R K+IA+S E   F + P  L ++ K +  K++I+ ++ +NDF+K L + QI  +V+CM  ++  A   +I+EGE G  ++V+ +G++ VS+EG  L +M+  TV GELAILYNCTRTA+V A+TD +LW +DR  FQ I  R G+ ++ + +NFL  V IF++L E  + K++ V+++ +Y  G YIIRQG KGD FF+I+SG+V+VT++ +  +T  +E  IR + +G++FGE+AL  E++RTANIIA  P GV+ L LDRES+ +LIGDL SL++ Y D   +  + +E   P K       E+  + LK++  +ATLG+GGFGRVELV +  +  KT+ALK LKK HIV+TRQQEHI  ERNI+    +D+IV+L++TF+D+KF+YML+EVCLGGELW+ LRDR  FD+ T +FY ACV+E L YLH + IVYRDLKPEN LL N G+ K+ DFGFAKK+  GRKTWTFCGTPEYV+PEIILNKGHD  AD W+LGI + EL+ G PPF A DPMK Y +ILKG+DA+E P ++I K A  L+KKLCRDNP ER+G G GGV + +KH W   F+W+GL S T+KPPI+P++++P D +NFD YPP+ ++PPD+ SGWD  F
Sbjct:  127 QRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE-GETEPRE--IRVLNQGDFFGERALLGEEVRTANIIAQAP-GVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

[Close]

Query:  659 ERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDG--VNDLPKEILGPSK-------EYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFP-KKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R K+IA+S E   F + P  L ++ K +  K++I+ ++ +NDF+K L + QI  +V+CM  ++  A   +I+EGE G  ++V+ +G++ VS+EG  L +M+  TV GELAILYNCTRTA+V A+TD +LW +DR  FQ I  R G+ ++ + +NFL  V IF++L E  + K++ V+++ +Y  G YIIRQG KGD FF+I+SG+V+VT++ +  +T  +E  IR + +G++FGE+AL  E++RTANIIA  P GV+ L LDRES+ +LIGDL SL++ Y D   +  + +E   P K       E+  + LK++  +ATLG+GGFGRVELV +  +  KT+ALK LKK HIV+TRQQEHI  ERNI+    +D+IV+L++TF+D+KF+YML+EVCLGGELW+ LRDR  FD+ T +FY ACV+E L YLH + IVYRDLKPEN LL N G+ K+ DFGFAKK+  GRKTWTFCGTPEYV+PEIILNKGHD  AD W+LGI + EL+ G PPF A DPMK Y +ILKG+DA+E P ++I K A  L+KKLCRDNP ER+G G GGV + +KH W   F+W+GL S T+KPPI+P++++P D +NFD YPP+ ++PPD+ SGWD  F
Sbjct:  158 QRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE-GETEPRE--IRVLNQGDFFGERALLGEEVRTANIIAQAP-GVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 780

[Close]

Query:  659 ERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDG--VNDLPKEILGPSK-------EYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFP-KKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R K+IA+S E   F + P  L ++ K +  K++I+ ++ +NDF+K L + QI  +V+CM  ++  A   +I+EGE G  ++V+ +G++ VS+EG  L +M+  TV GELAILYNCTRTA+V A+TD +LW +DR  FQ I  R G+ ++ + +NFL  V IF++L E  + K++ V+++ +Y  G YIIRQG KGD FF+I+SG+V+VT++ +  +T  +E  IR + +G++FGE+AL  E++RTANIIA  P GV+ L LDRES+ +LIGDL SL++ Y D   +  + +E   P K       E+  + LK++  +ATLG+GGFGRVELV +  +  KT+ALK LKK HIV+TRQQEHI  ERNI+    +D+IV+L++TF+D+KF+YML+EVCLGGELW+ LRDR  FD+ T +FY ACV+E L YLH + IVYRDLKPEN LL N G+ K+ DFGFAKK+  GRKTWTFCGTPEYV+PEIILNKGHD  AD W+LGI + EL+ G PPF A DPMK Y +ILKG+DA+E P ++I K A  L+KKLCRDNP ER+G G GGV + +KH W   F+W+GL S T+KPPI+P++++P D +NFD YPP+ ++PPD+ SGWD  F
Sbjct:  158 QRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE-GETEPRE--IRVLNQGDFFGERALLGEEVRTANIIAQAP-GVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 780

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0446099)

HSP 1 Score: 770.385 bits (1988), Expect = 0.000e+0
Identity = 375/621 (60.39%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E     + +      P ++K  +++ELIK +IL+NDFMKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:  128 QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 742

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089310)

HSP 1 Score: 769.229 bits (1985), Expect = 0.000e+0
Identity = 375/621 (60.39%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E     + +      P ++K  +++ELIK +IL+NDFMKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:  474 QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089312)

HSP 1 Score: 769.229 bits (1985), Expect = 0.000e+0
Identity = 375/621 (60.39%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E     + +      P ++K  +++ELIK +IL+NDFMKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:  474 QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089304)

HSP 1 Score: 769.229 bits (1985), Expect = 0.000e+0
Identity = 375/621 (60.39%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E     + +      P ++K  +++ELIK +IL+NDFMKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:  474 QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0473363)

HSP 1 Score: 741.11 bits (1912), Expect = 0.000e+0
Identity = 360/574 (62.72%), Postives = 451/574 (78.57%), Query Frame = 2

Query:  791 MKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            MKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:    1 MKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 568

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 811.601 bits (2095), Expect = 0.000e+0
Identity = 396/623 (63.56%), Postives = 482/623 (77.37%), Query Frame = 2

Query:  656 NERMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            ++R KR AIS E   F     S   LP++ K  ++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++   S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L+E  L K++ VLEETHY++G+YIIRQG +GDTFFIIS GKV VTR++ P+ T     ++R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DRES+  LIG L  +  + Y+D       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   69 HQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT---PVYLRALGKGDWFGEKALQGEDIRTANVIAAE--AVTCLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKYE--AENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 684

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 802.742 bits (2072), Expect = 0.000e+0
Identity = 387/600 (64.50%), Postives = 470/600 (78.33%), Query Frame = 2

Query:  716 EVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            E L    K +++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++   S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L+E  L K++ VLEETHY++G+YIIRQG +GDTFFIIS GKV VTR++ P+ T     ++R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DRES+  LIG L  +  + Y+D       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   77 EALRKHHKSVRSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT---PVYLRALGKGDWFGEKALQGEDIRTANVIAAE--AVTCLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKYE--AENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 669

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 778.859 bits (2010), Expect = 0.000e+0
Identity = 387/622 (62.22%), Postives = 465/622 (74.76%), Query Frame = 2

Query:  650 LSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            LSN+  +R+A S  S                   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV +  NS IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  ++  KLWAIDR  FQ+IMMRTGL+K+ E +  LKSV  F+ L E  L K++ VLEETHY +G+YIIRQG +GDTFFIIS GKV +TR++ P    ++  ++R M RG+ FGEKAL+ ED+RTAN+IAA+   V CLV+DR+SY  LIG L  +  +  ED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR  FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRD P+ER+G  K GVK+ QKH W E FNWDGL   T+ PPI+P + S TD SNFD +P + E  PPDD SGWD DF
Sbjct:   72 LSNQSFRRVAKSDRS-------------------KDLIKSAILDNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCP---GQEPVYLRSMGRGDSFGEKALQGEDIRTANVIAAET--VTCLVIDRDSYKHLIGGLEDVSNKGCEDAEAKAKYE--AENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 667

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 737.643 bits (1903), Expect = 0.000e+0
Identity = 364/600 (60.67%), Postives = 443/600 (73.83%), Query Frame = 2

Query:  716 EVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            E L    K +++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++   S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR S  + +              + S P                  +THY++G+YIIRQG +GDTFFIIS GKV VTR++ P+ T     ++R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DRES+  LIG L  +  + Y+D       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   77 EALRKHHKSVRSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQSLTAFIS-------------IHSSPT----------------PDTHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT---PVYLRALGKGDWFGEKALQGEDIRTANVIAAE--AVTCLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKYE--AENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 640

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: CR925795.1 (protein kinase cGMP-dependent 1b [Source:NCBI gene;Acc:566430])

HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0
Identity = 284/442 (64.25%), Postives = 347/442 (78.51%), Query Frame = 2

Query: 1190 LEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            L  THY++G+YIIRQG +GDTFFIIS GKV VTR++ P+ T     ++R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DRES+  LIG L  +  + Y+D       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   14 LINTHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT---PVYLRALGKGDWFGEKALQGEDIRTANVIAAE--AVTCLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKYE--AENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 448

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 808.135 bits (2086), Expect = 0.000e+0
Identity = 400/636 (62.89%), Postives = 486/636 (76.42%), Query Frame = 2

Query:  620 EENNKNGDFKLSNERMKRIAISGESGTFISSPEV----LPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            ++ +K     L  +R KR AIS E  T I   E+    LP++ K  ++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  + K++ VLEETHY +GDYIIRQG +GDTFFIIS GKV VTR++ P    E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   58 QQVHKQNPTTLGEQRTKRQAISAEP-TAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSP---GEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

[Close]

Query:  620 EENNKNGDFKLSNERMKRIAISGESGTFISSPEV----LPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            ++ +K     L  +R KR AIS E  T I   E+    LP++ K  ++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  + K++ VLEETHY +GDYIIRQG +GDTFFIIS GKV VTR++ P    E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   58 QQVHKQNPTTLGEQRTKRQAISAEP-TAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSP---GEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 799.66 bits (2064), Expect = 0.000e+0
Identity = 392/617 (63.53%), Postives = 474/617 (76.82%), Query Frame = 2

Query:  677 AISGESGTFIS----SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
             IS E  +F S    + +    F K  ++KELIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  + K++ VLEETHY +GDYIIRQG +GDTFFIIS GKV VTR++ P    E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:   64 GISAEPQSFRSYHDLTRQAFKKFTKSERSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSP---GEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 673

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: ptafr (platelet activating factor receptor [Source:Xenbase;Acc:XB-GENE-968925])

HSP 1 Score: 625.935 bits (1613), Expect = 0.000e+0
Identity = 311/616 (50.49%), Postives = 421/616 (68.34%), Query Frame = 2

Query:  737 KHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLP--------------KEILGPSKEYKNL-----------ALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            K+   K LI  ++ +N FMK ++  QI+ +V+CM    +     II++GE GS ++V+ DGK  V +E   L  +   T FGELAILYNCTRTA+V AIT  + WA+DR  FQ+IM +T   K+EE L+FLKSVP+ K+L E  L KI+  LE   Y   DYIIR+G +G TFFIIS GKV+VT+     +  ++ Q+I+ +++G++FGEKAL  +D+R+ANI+A     V+CLV+DRE++ + +G    L +  E  V +L               + +   S E   +             ++L ++ TLG+GGFGRVELV++  N    +ALK +KK HIV+ RQQEHI +E+NIL    S FIV+L+ TFKD K++YML+E CLGGELWSILRDR +FDE T KF T CV EA  YLH +G++YRDLKPENLLLD++G+ K+ DFGFAKKI  G+KTWTFCGTPEYVAPE+ILNKGH    D WSLGIL++ELLTG PPFT PD M IYN+IL+GI+ IEF K I+K  ++LI++LCR+NP ER+G  K G+ + +KH W   FNW+GL + ++  P+ P++  PTD S FD YPP+ E+PPD++SGWD+DF
Sbjct:  177 KNTSEKILISDALNKNQFMKRMDHHQIQDMVECMYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQENKLLTSIPVWTTFGELAILYNCTRTASVKAITGVRTWALDREVFQNIMRKTAQSKHEEYLSFLKSVPLLKELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIISKGKVKVTQST---EGYKEPQYIKFLEKGDYFGEKALISDDVRSANILAYGDR-VECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERRHAKSPVNERHLRAVSMELNKMKQTLARFPSASPFENLEIVTTLGVGGFGRVELVKV-KNENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKNITKRPEDLIRRLCRENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPPDEEIPPDEVSGWDQDF 787

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 614.764 bits (1584), Expect = 0.000e+0
Identity = 296/460 (64.35%), Postives = 359/460 (78.04%), Query Frame = 2

Query: 1136 VPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            VP F+ L E  + K++ VLEETHY +GDYIIRQG +GDTFFIIS GKV VTR++ P    E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P + E  PPDD SGWD DF
Sbjct:    4 VPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSP---GEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 456

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BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 807.364 bits (2084), Expect = 0.000e+0
Identity = 394/621 (63.45%), Postives = 479/621 (77.13%), Query Frame = 2

Query:  662 RMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
            R KR AIS E   F     S   LP++ K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L +  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G+V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P ++ E PPDD SGWD DF
Sbjct:   73 RTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 797.349 bits (2058), Expect = 0.000e+0
Identity = 390/616 (63.31%), Postives = 475/616 (77.11%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLKT---KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K+   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L +  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G+V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P ++ E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 627.476 bits (1617), Expect = 0.000e+0
Identity = 328/691 (47.47%), Postives = 451/691 (65.27%), Query Frame = 2

Query:  539 LNSSQNNQVLCYNCGAKLQLAYIYTDIEENNK-NGDFKLSNERMKRIAISGESGTFISSPEVLPYF-------EKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDL--------PKEILGPSKEYKNLAL------------------KDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            LN  Q+  V+    G+ LQ +     ++ + K +G   L + R  +  +S E  T        P F        K    K+LI  ++ +N F+K L+  QIK +V+CM    +   S +IK+GE G+ ++V+ +G++ V +    L  +   T FGELAILYNCTRTA+V AIT+ K WA+DR  FQ+IM RT   + EE  NFL+SV + K+L E  L KI   LE  +Y  GDYIIR+G +G TFFI++ GKV+VT+  +  D   + Q I+ +Q+GE+FGEKAL  +D+R+ANIIA +   V CLV+DRE++ Q +G    LQ+  E  V  L         K  +   K  K L+L                  ++L +IATLG+GGFGRVELV++  N    +A+K ++K HIV+T+QQEH+ +E+ IL  + S FIV+L+RTFKD K++YML+E CLGGELWSILRDR +FDE T+KF  ACV EA  YLH  GI+YRDLKPENL+LD  G+ K+ DFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD   D WSLGIL++ELLTG PPF+  D M  YN+ILKGI+ ++FP+KI++  ++LI++LCR NP ER+G  K G+ + +KH WL  FNW+GL + ++  P+  +++ P D S FD+YPPE  +PPD++SGWD+DF
Sbjct:   79 LNKLQD--VIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD---QPQLIKTLQKGEYFGEKALISDDVRSANIIAEE-NDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF 762

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 605.52 bits (1560), Expect = 0.000e+0
Identity = 313/670 (46.72%), Postives = 439/670 (65.52%), Query Frame = 2

Query:  539 LNSSQNNQVLCYNCGAKLQLAYIYTDIEENNK-NGDFKLSNERMKRIAISGESGTFISSPEVLPYF-------EKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKK-----TYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            LN  Q+  V+    G+ LQ +     ++ + K +G   L + R  +  +S E  T        P F        K    K+LI  ++ +N F+K L+  QIK +V+CM    +   S +IK+GE G+ ++V+ +G++ V +    L  +   T FGELAILYNCTRTA+V AIT+ K WA+DR  FQ+IM RT   + EE  NFL+SV + K+L E  L KI   LE  +Y  GDYIIR+G +G TFFI++ GKV+VT+  +  D   + Q I+ +Q+GE+FGEKAL  +D+R+ANIIA +   V CLV+DRE++ Q +G    LQ+  E  V  L ++     K +   ++    +   L +      E++Q+ + VK       +A+K ++K HIV+T+QQEH+ +E+ IL  + S FIV+L+RTFKD K++YML+E CLGGELWSILRDR +FDE T+KF  ACV EA  YLH  GI+YRDLKPENL+LD  G+ K+ DFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD   D WSLGIL++ELLTG PPF+  D M  YN+ILKGI+ ++FP+KI++  ++LI++LCR NP ER+G  K G+ + +KH WL  FNW+GL + ++  P+  +++ P D S FD+YPPE  +PPD++SGWD+DF
Sbjct:   79 LNKLQD--VIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD---QPQLIKTLQKGEYFGEKALISDDVRSANIIAEE-NDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRD---DEKRHAKRSMSSWKLSKALSL------EMIQLKEKVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF 733

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 482.641 bits (1241), Expect = 6.818e-163
Identity = 235/381 (61.68%), Postives = 285/381 (74.80%), Query Frame = 2

Query: 1373 LKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
            + +ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCR                     W E FNW+GL   T+ PPI+P + SPTD SNFD +P ++ E PPDD SGWD DF
Sbjct:   27 ISEEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR---------------------WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 382

[Close]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|P00516|KGP1_BOVIN (cGMP-dependent protein kinase 1 OS=Bos taurus OX=9913 GN=PRKG1 PE=1 SV=2)

HSP 1 Score: 800.816 bits (2067), Expect = 0.000e+0
Identity = 393/616 (63.80%), Postives = 474/616 (76.95%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLKT---KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K+   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY NG+YIIRQG +GDTFFIIS GKV VTR++ P   NE   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P +  E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSP---NEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|P0C605|KGP1_MOUSE (cGMP-dependent protein kinase 1 OS=Mus musculus OX=10090 GN=Prkg1 PE=1 SV=1)

HSP 1 Score: 797.349 bits (2058), Expect = 0.000e+0
Identity = 390/616 (63.31%), Postives = 475/616 (77.11%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLKT---KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K+   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L +  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G+V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P ++ E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|Q13976|KGP1_HUMAN (cGMP-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PRKG1 PE=1 SV=3)

HSP 1 Score: 797.349 bits (2058), Expect = 0.000e+0
Identity = 391/616 (63.47%), Postives = 473/616 (76.79%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLKT---KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K+   K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY NG+YIIRQG +GDTFFIIS G V VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P +  E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP---SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|O77676|KGP1_RABIT (cGMP-dependent protein kinase 1 OS=Oryctolagus cuniculus OX=9986 GN=PRKG1 PE=1 SV=3)

HSP 1 Score: 790.415 bits (2040), Expect = 0.000e+0
Identity = 389/616 (63.15%), Postives = 471/616 (76.46%), Query Frame = 2

Query:  677 AISGESGTFISSPEVLPYFEKHLK---TKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPET-EMPPDDISGWDRDF 2509
             IS E  T+ S  ++   F K  K   +K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSL YVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  + + KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY N +Y IRQG +GDTFFIIS GKV VTR++ P   +E   F+R + +G+WFGEKAL+ ED+RTAN+IAA+   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SPTD SNFD +P +  E PPDD SGWD DF
Sbjct:   63 GISAEPQTYRSFHDLRQAFRKFTKFERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLAYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENEEYSIRQGARGDTFFIISKGKVNVTREDSP---SEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAE--AVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAE--AAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDGFPEDNDEPPPDDNSGWDIDF 671

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|Q03043|KGP24_DROME (cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster OX=7227 GN=for PE=1 SV=3)

HSP 1 Score: 769.229 bits (1985), Expect = 0.000e+0
Identity = 375/621 (60.39%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E     + +      P ++K  +++ELIK +IL+NDFMKNL+ +QI+ IVDCM PVK+ A ++IIKEG+VGS+VYVMEDG+V VS+EG +L  +    V GELAILYNC RTAT+TAIT+C LWAI+R  FQ+IMMRTGL++  E  +FLKSVPIFKDL E TL KIS VLEETHY  GDYI+RQG +GDTFFIIS GKV+VT K +  DT E E+FIR + +G++FGEKAL+ +DLRTANII     GV CLV+DRE++ QLI +L  ++  Y+D      ++I   ++E++++ L DL VIATLG+GGFGRVELVQ   +  +++ALKQ+KK  IVETRQQ+HIM+E+ I+      FIV+L +TFKD+K+LYMLME CLGGELW+ILRD+  FD++TT+FYTACV+EA  YLHSR I+YRDLKPENLLL+ +G+ K+ DFGFAKK+  GRKTWTFCGTPEYVAPE+ILN+GHD  AD WSLG+LMFELLTG PPFT  DPM+ YNIILKGIDAIEFP+ I+++A NLIKKLCRDNP ER+GY +GG+ E QKH W + F W GL + T++PPI P + S  D +NF D  P     PPDD++GWD+DF
Sbjct:  474 QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DTQE-EKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKI---NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A267FLY4 (cGMP-dependent protein kinase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig030852g1 PE=3 SV=1)

HSP 1 Score: 861.677 bits (2225), Expect = 0.000e+0
Identity = 404/617 (65.48%), Postives = 491/617 (79.58%), Query Frame = 2

Query:  662 RMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSK-EGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            R KR+AISGES    ++  V P  EK  +T++LI+R+ILEN FMKNLE +QI  I+D M P+    N++IIK GE+GSLVYVME+G   V+  +G  + E+ + TVFGELAILYNC RTATV A+T+CKLWAIDR +FQSIMM+TGLLK++E + FLKSVP FK+L   TL K++ VLE  HY NG+YIIRQG KG+TF+II+ G V+VT++   D    +  FIR M RG+WFGEKAL +ED+RTANII  DP GVDCLVL+RESY QLIGDL  L R Y D     P      S+E+K L LKDL +IATLG+GGFGRVELV+I ++  +++ALKQLKKHHIVETRQQEHIMNER+IL     DFIV+L+RTFKDRK+LYMLME CLGGELW+ILRD+  FD++TT+FY  CV+EAL YLH +GIVYRDLKPENLLLD  G+CKITDFGFAK+IGFG+KTWTFCGTPEYV PE+ILNKGHD  AD WSLG+LMFELLTG PPFTA DPMK YNIILKGIDA++FP++IS++AQNL+KKLCRDNP ER+G G+GGV E  KH+W E FNW G+ S T+ PPI+P+++S  D SNFDEYP + E PPDD+SGWD+DF
Sbjct:   78 RTKRVAISGESSAEFANSNVKPC-EKSTRTRDLIRRAILENAFMKNLENAQISEIIDYMYPMTHKTNALIIKLGEIGSLVYVMEEGSAEVTNTKGDKINEIGSGTVFGELAILYNCKRTATVKALTNCKLWAIDRQTFQSIMMKTGLLKHKEYMEFLKSVPAFKELPGETLSKLADVLEADHYPNGEYIIRQGAKGNTFYIIAKGNVRVTKR---DSATGESVFIRNMGRGDWFGEKALNEEDVRTANIIVEDPNGVDCLVLNRESYKQLIGDLAILGRKYSDESTAQPSR----SEEFKGLTLKDLFIIATLGVGGFGRVELVRIRNDNSRSFALKQLKKHHIVETRQQEHIMNERSILADANCDFIVKLYRTFKDRKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYIGCVVEALQYLHRKGIVYRDLKPENLLLDTTGYCKITDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLTADFWSLGVLMFELLTGTPPFTASDPMKTYNIILKGIDAVDFPRRISRNAQNLVKKLCRDNPTERLGVGRGGVMEVSKHIWFEGFNWAGMNSKTLTPPILPKVSSAVDASNFDEYPADNEHPPDDVSGWDKDF 686

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: V3ZX54 (cGMP-dependent protein kinase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_210612 PE=3 SV=1)

HSP 1 Score: 857.825 bits (2215), Expect = 0.000e+0
Identity = 408/622 (65.59%), Postives = 498/622 (80.06%), Query Frame = 2

Query:  659 ERMKRIAISGESGTFISSPEVL----PYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            ER KR AIS E   F ++  VL     +  K L +KELI+++IL+NDFMKNLE  QI+ IV+CM PV+F  +SIIIKEG+VGSLVYVMEDGKV V+K+G  L  M    VFGELAILYNCTRTA+V A+  C+LWAIDR  FQSIMMRTGL ++ E+L FL+SVP F  L E TLGKI+ VLEE HY NG+YIIRQG +GD+F+II+ GKV+VT+++     + +E  +R +Q+G++FGE+AL+ ED+RTANIIA DP GVDCL +DRE+Y QLI +L  L+R YED      +E LG   EY  + L DL V++TLG+GGFGRVELVQI ++  K YALK LKKHHIVETRQQEHIMNE+ I+   +  FIVRLHRTF+DRK+LYML+E CLGGELW++LRD+ +FD+NTT+FYTACV+EA +YLHSRGIVYRDLKPENLL+D+ G+ K+ DFGFAKK+G GRKTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF  PDPMK YN+ILKGIDAI+FP+KI+K+AQ LIKKLCRDNP ER+GYG+GG++E QKH W E FNWDGL + ++KPPI+P I SPTD SNFD+YP + +  PPDD+SGWD+DF
Sbjct:   73 ERSKRTAISAEPANF-NTFHVLDSETQFVAKSLSSKELIRQAILDNDFMKNLELGQIREIVECMYPVEFTKDSIIIKEGDVGSLVYVMEDGKVEVTKDGQKLCTMSPGKVFGELAILYNCTRTASVKALQACRLWAIDRPCFQSIMMRTGLQRHSEHLEFLRSVPTFDGLPEETLGKIADVLEEAHYNNGEYIIRQGARGDSFYIIAKGKVRVTKRSS---KSHEEVTMRYLQKGDFFGERALQGEDVRTANIIAHDPDGVDCLTIDREAYSQLISNLDDLKRIYEDD-----EEKLGIDSEYAKIKLSDLHVLSTLGVGGFGRVELVQINNDNSKAYALKILKKHHIVETRQQEHIMNEKRIMSEARCAFIVRLHRTFRDRKYLYMLLESCLGGELWTVLRDKGSFDDNTTRFYTACVVEAFNYLHSRGIVYRDLKPENLLMDSTGYVKLVDFGFAKKVGHGRKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFAGPDPMKTYNLILKGIDAIDFPRKITKNAQILIKKLCRDNPLERLGYGRGGIREIQKHTWFEGFNWDGLRNRSMKPPIIPVIKSPTDTSNFDDYPEDEDGPPPDDLSGWDKDF 685

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A267FPA9 (cGMP-dependent protein kinase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003256g1 PE=3 SV=1)

HSP 1 Score: 845.884 bits (2184), Expect = 0.000e+0
Identity = 397/623 (63.72%), Postives = 490/623 (78.65%), Query Frame = 2

Query:  659 ERMKRIAISGESG-----TFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSK-EGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E       + +S+ +++P   K   T++LI+R+ILEN FMKNLE +QI  I+D M P+    N++IIK GE+GSLVYVME+G   V+  +G  + E+ + TVFGELAILYNC RTATV A+++CKLWAIDR +FQSIMM+TGLLK++E + FLKSVP FK+L   TL K++ VLE  HY NG+YIIRQG KG+TF+II+ G V+VT++   D    +  FIR M RG+WFGEKAL +ED+RTANII  DP GVDCLVL+RESY QLIGDL  L R Y D     P      S+E+K L LKDL +IATLG+GGFGRVELV+I ++  +++ALKQLKKHHIVETRQQEHIMNER+IL     DFIV+L+RTFKDRK+LYMLME CLGGELW+ILRD+  FD++TT+FY  CV+EAL YLH +GIVYRDLKPENLLLD  G+CKITDFGFAK+IGFG+KTWTFCGTPEYV PE+ILNKGHD  AD WSLG+LMFELLTG PPFTA DPMK YNIILKGIDA++FP++IS++AQNL+KKLCRDNP ER+G G+GGV E  KH+W E FNW G+ S T+ PPI+P+++S  D SNFDEYP + E PPDD+SGWD+DF
Sbjct:   95 KRQRGVGISAEPQNEQLVSQMSTGKIVP---KDAGTRDLIRRAILENAFMKNLENAQISEIIDYMYPMTHKTNALIIKLGEIGSLVYVMEEGSAEVTNTKGDKINEIGSGTVFGELAILYNCKRTATVKALSNCKLWAIDRQTFQSIMMKTGLLKHKEYMEFLKSVPAFKELPGETLSKLADVLEADHYPNGEYIIRQGAKGNTFYIIAKGNVRVTKR---DSATGESVFIRNMGRGDWFGEKALNEEDVRTANIIVEDPNGVDCLVLNRESYKQLIGDLAILGRKYSDESTAQPSR----SEEFKGLTLKDLFIIATLGVGGFGRVELVRIRNDNSRSFALKQLKKHHIVETRQQEHIMNERSILAEANCDFIVKLYRTFKDRKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYIGCVVEALQYLHRKGIVYRDLKPENLLLDTTGYCKITDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLTADFWSLGVLMFELLTGTPPFTASDPMKTYNIILKGIDAVDFPRRISRNAQNLVKKLCRDNPTERLGVGRGGVMEVSKHIWFEGFNWAGMNSKTLTPPILPKVSSAVDASNFDEYPADNEHPPDDVSGWDKDF 707

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A267GV06 (cGMP-dependent protein kinase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011874g1 PE=3 SV=1)

HSP 1 Score: 845.499 bits (2183), Expect = 0.000e+0
Identity = 397/623 (63.72%), Postives = 490/623 (78.65%), Query Frame = 2

Query:  659 ERMKRIAISGESG-----TFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSK-EGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +R + + IS E       + +S+ +++P   K   T++LI+R+ILEN FMKNLE +QI  I+D M P+    N++IIK GE+GSLVYVME+G   V+  +G  + E+ + TVFGELAILYNC RTATV A+++CKLWAIDR +FQSIMM+TGLLK++E + FLKSVP FK+L   TL K++ VLE  HY NG+YIIRQG KG+TF+II+ G V+VT++   D    +  FIR M RG+WFGEKAL +ED+RTANII  DP GVDCLVL+RESY QLIGDL  L R Y D     P      S+E+K L LKDL +IATLG+GGFGRVELV+I ++  +++ALKQLKKHHIVETRQQEHIMNER+IL     DFIV+L+RTFKDRK+LYMLME CLGGELW+ILRD+  FD++TT+FY  CV+EAL YLH +GIVYRDLKPENLLLD  G+CKITDFGFAK+IGFG+KTWTFCGTPEYV PE+ILNKGHD  AD WSLG+LMFELLTG PPFTA DPMK YNIILKGIDA++FP++IS++AQNL+KKLCRDNP ER+G G+GGV E  KH+W E FNW G+ S T+ PPI+P+++S  D SNFDEYP + E PPDD+SGWD+DF
Sbjct:   95 KRQRGVGISAEPQNEQLVSQMSTGKIVP---KDAGTRDLIRRAILENAFMKNLENAQISEIIDYMYPMTHKTNALIIKLGEIGSLVYVMEEGSAEVTNTKGDKINEIGSGTVFGELAILYNCKRTATVKALSNCKLWAIDRQTFQSIMMKTGLLKHKEYMEFLKSVPAFKELPGETLSKLADVLEADHYPNGEYIIRQGAKGNTFYIIAKGNVRVTKR---DSATGESVFIRNMGRGDWFGEKALNEEDVRTANIIVEDPNGVDCLVLNRESYKQLIGDLAILGRKYSDESTAQPTR----SEEFKGLTLKDLFIIATLGVGGFGRVELVRIRNDNSRSFALKQLKKHHIVETRQQEHIMNERSILAEANCDFIVKLYRTFKDRKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYIGCVVEALQYLHRKGIVYRDLKPENLLLDTTGYCKITDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLTADFWSLGVLMFELLTGTPPFTASDPMKTYNIILKGIDAVDFPRRISRNAQNLVKKLCRDNPTERLGVGRGGVMEVSKHIWFEGFNWAGMNSKTLTPPILPKVSSAVDASNFDEYPADNEHPPDDVSGWDKDF 707

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: K1QUW8 (cGMP-dependent protein kinase OS=Crassostrea gigas OX=29159 GN=CGI_10021856 PE=3 SV=1)

HSP 1 Score: 832.402 bits (2149), Expect = 0.000e+0
Identity = 402/625 (64.32%), Postives = 501/625 (80.16%), Query Frame = 2

Query:  653 SNERMKRIAISGESGTFISSPEVLPYFE-----KHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 2509
            S +R+KR AIS ES    +S ++L  ++     K   +++LI+ +IL+NDFMKNL+  QI+ IVDCM PV +  +S+IIKEG+VGSLVYVME+GKV V+K+G  L  M    VFGELAILYNCTRTA+V A+ +CKLWAIDR  FQSIMMRTGL+++EE+++FL+SVP FK L E  + KI+ VLEE HY NG+YIIRQG +GDTF+II+ GKV+VTR++        EQ IR +Q+GE+FGE+AL+ ED+RTA+I+AADP GV+CLV+DRESY+QLI DL  L+R YED   D  K +    +E+  L L DL ++ATLG+GGFGRVELVQ+ ++  +T+ALK LKKHHIVETRQQEHIMNE+ I+   +SDFIVRL+RTFKDRK+LYML+EVCLGGELW++LRD+ +FD+ TT+FYT CVIEA  YLH++GIVYRDLKPENLLLD+QG+ K+ DFGFAKK+G GRKTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF+  DPMK YNIILKGIDAI+F +KISK+AQNLIKKLCR+ P++R+G+G+GG++E QKH W E FNWDGL   T+KPPI PQ+ S TD SNF D    E + PPDD++GWDRDF
Sbjct:   76 SRDRIKRTAISAESP---NSSQILATYKTVKVPKSNDSRDLIRSAILDNDFMKNLDMGQIREIVDCMYPVDYTKDSLIIKEGDVGSLVYVMEEGKVEVTKDGQKLCTMGPAKVFGELAILYNCTRTASVKALVNCKLWAIDRPCFQSIMMRTGLMRHEEHMDFLRSVPTFKHLPEELVSKIADVLEEAHYNNGEYIIRQGARGDTFYIIAKGKVKVTRRHSK---TGDEQLIRCLQKGEFFGERALQGEDVRTASIVAADPTGVECLVIDRESYLQLISDLDELKRVYED---DEEKAV--ADQEFMKLKLSDLSIVATLGVGGFGRVELVQVNNDNSRTFALKILKKHHIVETRQQEHIMNEKKIMSESRSDFIVRLYRTFKDRKYLYMLLEVCLGGELWTVLRDKGSFDDATTRFYTGCVIEAFAYLHNKGIVYRDLKPENLLLDSQGYVKLVDFGFAKKVGLGRKTWTFCGTPEYVAPEIILNKGHDISADFWSLGILMFELLTGSPPFSGQDPMKTYNIILKGIDAIDFSRKISKNAQNLIKKLCRETPSDRLGFGRGGIREIQKHKWFEGFNWDGLKKRTLKPPITPQVKSATDTSNFDDYPDEEDDPPPDDVTGWDRDF 689

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 788.104 bits (2034), Expect = 0.000e+0
Identity = 391/627 (62.36%), Postives = 472/627 (75.28%), Query Frame = 2

Query:  650 LSNERMKRI-AISGESGTFIS----SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            L   R +R   IS E   F S    + E L    K  ++KELIK +IL+NDFMKNLE SQI+ I  C           IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F+ L E  L K++ VLEETHY +G+YIIRQG +GDTFFIIS GKV VTR++ P DT     ++R + +G+WFGEKAL+ ED+RTAN+IAAD   V CLV+DR+S+  LIG L  +  + YED       E    +  + NL L D  +I TLG+GGFGRVELVQ+     KT+A+K LKK HIV+TRQQEHI +E++I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP+ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P ++SPTD SNFD +P ++E  PPDD SGWD DF
Sbjct:   52 LMGPRTRRAQGISAEPQPFTSFQQLTSEALRKHAKSDRSKELIKEAILDNDFMKNLELSQIQEIESC-----------IIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLAEEILSKLADVLEETHYDDGEYIIRQGARGDTFFIISKGKVNVTREDSPSDT---PVYLRALGKGDWFGEKALQGEDIRTANVIAAD--AVTCLVIDRDSFKHLIGGLDDVSSKGYEDAGAKAKYE--AENAFFSNLKLADFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKHIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPDVSSPTDTSNFDSFPEDSEDPPPDDNSGWDTDF 660

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 704.131 bits (1816), Expect = 0.000e+0
Identity = 366/624 (58.65%), Postives = 443/624 (70.99%), Query Frame = 2

Query:  656 NERMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANI-IAADPAGVDCLVLDRESYIQLIGDLTSL-QRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
             +R KR AIS E   F     S   LP+  K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV+++ +S IIKEG+VGSLVYVMEDGKV V+KEG  L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E + FLKSVP F  L E  L K+  VLEETHY +GDYIIRQG +GDTFFIIS GKV VTR+   D  +++  ++R + +G+WFGEKAL+   +   N  +      ++C      SY  LIG L  +  +  ED       E    +  + NL L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFI    +TFKD K+LYML E CL      I   R +FD++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G     DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRD P+ER+G  K GVK+ QKH W E FNW+GL   T+ PP  P + S TD SNFD +P + E  PPDD SGWD DF
Sbjct:   69 QQRTKRQAISAEPTAFDIQELSHVTLPFNPKSAQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYSKDSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFHGLPEEILSKLGDVLEETHYEDGDYIIRQGARGDTFFIISKGKVTVTRE---DAASQETVYLRSLGKGDWFGEKALQGNQISCLNTDLITLSTFINCW-----SYKHLIGGLEDVSSKGSEDAEAKAKYE--AENAFFFNLHLSDFNIIDTLGVGGFGRVELVQLKSDEYKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFITV--QTFKDSKYLYMLHEACLEESCGPIPETRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRG-----DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPSSP-VTSATDTSNFDSFPEDNEDPPPDDNSGWDGDF 674

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 617.846 bits (1592), Expect = 0.000e+0
Identity = 312/651 (47.93%), Postives = 427/651 (65.59%), Query Frame = 2

Query:  650 LSNERMKRIAISGE--SGTFISSPEVLPYFE-----KHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYE-----------------DGVNDLPKEILGPSK---EYKN----LALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            L+  +  +  +S E  S T+ SS     YFE     K    K+L+  ++ +N +++ LE  QIK +V+CM    +     +IK+GE G+ ++V+ DG + V +    L  +   T FGELAILYNCTRTA+V A +  + W +DR  F +IM  T   ++E++ +FL+SV +   L E  L KI   LE  +Y  GDY+IR+G +G+TF+II+ GKV+VT+  K    +E+ Q I  +Q+G++FGEKAL  +D+R+ANIIA D  GV+CLV+DRE++ Q +G    L++  +                  G N  P   L   +     KN    L+  +L +IATLGIGGFGRVELV++  N   T+ALK +KK HIV+ RQ+EHI +ER IL    S FIV+++RTFKD K++YML+E CLGGE+WS+LRDR +F+ENT KF   CV EA  YLH++ I+YRDLKPENL+LD+ G+ K+ DFGFAKK+  G+KTWTFCGTPEYVAPEIILNKGH    D W+LGIL+FELLTG PPFT  D M  Y  ILKG++ ++FPKKISK   +LI+KLC+ NP+ER+G  K G+ + +KH W   F+W GL + T+  P+  ++  PTD S FD YPPE E+PPD+ISGWD DF
Sbjct:  122 LNKRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTK---DHEEPQVINTLQKGDYFGEKALISDDVRSANIIA-DEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELVKV-KNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWDMDF 767

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000002114.2 (cGMP-dependent protein kinase 2-like [Source:NCBI gene;Acc:103041230])

HSP 1 Score: 611.298 bits (1575), Expect = 0.000e+0
Identity = 310/611 (50.74%), Postives = 421/611 (68.90%), Query Frame = 2

Query:  752 KELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDL-------------PKEILGP-SKEYKNLA-----------LKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            K+LI  +I+ NDF+K LE    + +VDCM    + AN ++I+EGE G+ +YV+ +G + V + G  L +M+  T FGELAILYNC RTATV A+T   +WA+DR +FQSIMMR+   ++EE  +FL+SV + KDL E  L KI   LE  ++  G+YIIR+G +G+TFFII+ G+V VT+     +   +   I+ +  G++FGEKAL  ED+R+ANIIA +     CLV+DR+++ Q++G    LQ    + V  L             P     P + E ++L            L+ L +IATLG+GGFGRVELV++  N    +ALK +KK HIV+TRQQEHI +E+NIL     +FIVRL RTF+D K++YML+EVCLGGELWS+LRD S F+E T +F   CV+EA  YLH  GIVYRDLKPENLLLD +G+ K+TDFGFAK+IG G+KTWTFCGTPEYVAPE+I+NKGHD  ADCWSLGIL+FELL G PPF+  DP+KIY ++L GI+ ++ PK+ISK  ++LI++LC+ NP ER+G  K G+ + +KH W + FNW+GL    +  P+  ++N P D S+FD +PPE E PPD++SGWD+DF
Sbjct:  165 KKLINEAIMNNDFLKKLEPQHTREMVDCMYEKVYTANQLVIQEGEPGNYLYVLAEGLLEVIQNGKLLGQMRPGTAFGELAILYNCKRTATVKAVTQSHIWALDRQTFQSIMMRSTQARHEEYFSFLRSVSLLKDLPEEKLAKIVDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQST---EGYSEPLEIKILGVGDYFGEKALISEDVRSANIIAKE-NDTQCLVVDRDNFNQMVGTYEELQAYLREYVEQLSINDERRIAATQSPLYERSPQAAELRSLHEKAARLSSCSFLQQLQIIATLGMGGFGRVELVKL-KNEDTAFALKCIKKKHIVDTRQQEHIYSEKNILQQTNCNFIVRLFRTFRDEKYVYMLLEVCLGGELWSVLRDMSFFEEATARFCIGCVLEAFDYLHGMGIVYRDLKPENLLLDAEGYVKMTDFGFAKRIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFSGSDPIKIYTMVLHGIEKVDIPKRISKRPEDLIRRLCKLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLASPLRRELNGPLDHSHFDMFPPELEEPPDELSGWDKDF 770

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 588.571 bits (1516), Expect = 0.000e+0
Identity = 296/627 (47.21%), Postives = 415/627 (66.19%), Query Frame = 2

Query:  650 LSNERMKRIAISGE--SGTFISSPEVLPYFE-----KHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            L+  +  +  +S E  S T+ SS     YFE     K    K+L+  ++ +N +++ LE  QIK +V+CM    +     +IK+GE G+ ++V+ DG + V +    L  +   T FGELAILYNCTRTA+V A +  + W +DR  F +IM  T   ++E++ +FL+SV +   L E  L KI   LE  +Y  GDY+IR+G +G+TF+II+ GKV+VT+  K    +E+ Q I  +Q+G++FGEKAL  +D+R+ANIIA D  GV+CLV+DRE++ Q +G    L++  +  V  L ++      + K  A   L+ + +  +    +V+     +NV  T+ALK +KK HIV+ RQ+EHI +ER IL    S FIV+++RTFKD K++YML+E CLGGE+WS+LRDR +F+ENT KF   CV EA  YLH++ I+YRDLKPENL+LD+ G+ K+ DFGFAKK+  G+KTWTFCGTPEYVAPEIILNKGH    D W+LGIL+FELLTG PPFT  D M  Y  ILKG++ ++FPKKISK   +LI+KLC+ NP+ER+G  K G+ + +KH W   F+W GL + T+  P+  ++  PTD S FD YPPE E+PPD+ISGWD DF
Sbjct:  122 LNKRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTK---DHEEPQVINTLQKGDYFGEKALISDDVRSANIIA-DEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARD------DKKRNAKWFLIAVCSSQV----KVK----NENV--TFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWDMDF 728

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002200.1 (pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 gene:ENSPMAG00000001993.1 transcript:ENSPMAT00000002200.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 399.823 bits (1026), Expect = 2.546e-132
Identity = 175/309 (56.63%), Postives = 239/309 (77.35%), Query Frame = 2

Query: 1583 VIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            VIATLG+GGFGRV+LV++ D+   T+ALK LKK  +VE+RQQEH+ +E+ IL      FIVR +RTF+D+KF+++LME CLGGELWS+LRD   F E + +F  ACV+EAL YLH+RGI+YRDLKPENLLLD +G+ K+ DFGFAKK+  GRK WTFCGTPEYV PE+I+N+GHD  ADCW+LG+L++ELL G+PPF+  DPMK YN IL G++ + FP ++ K A+++I++LCR NP+ER+G  K GV + +KH W + F+W+ L S+ +  P+  +++ PTD  NFD +P + ++PPD+ SGWD DF
Sbjct:   36 VIATLGVGGFGRVQLVKLKDS-DVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVRFYRTFRDQKFVFLLMEACLGGELWSVLRDSGGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPNEVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHDF 343

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002201.1 (pep scaffold:Pmarinus_7.0:GL479132:31244:36797:-1 gene:ENSPMAG00000001993.1 transcript:ENSPMAT00000002201.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 332.798 bits (852), Expect = 1.231e-107
Identity = 154/308 (50.00%), Postives = 211/308 (68.51%), Query Frame = 2

Query: 1586 IATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            IATLG+GGFGRV+LV++ D+   T+ALK LKK  +VE+RQQEH+ +E+ IL      FIVR                                F E + +F  ACV+EAL YLH+RGI+YRDLKPENLLLD +G+ K+ DFGFAKK+  GRK WTFCGTPEYV PE+I+N+GHD  ADCW+LG+L++ELL G+PPF+  DPMK YN IL G++ + FP ++ K A+++I++LCR NP+ER+G  K GV + +KH W + F+W+ L S+ +  P+  +++ PTD  NFD +P + ++PPD+ SGWD DF
Sbjct:    1 IATLGVGGFGRVQLVKLKDS-DVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVR------------------------------GGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPNEVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHDF 277

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001814.1 (pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gene:ENSPMAG00000001637.1 transcript:ENSPMAT00000001814.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 251.521 bits (641), Expect = 7.608e-77
Identity = 120/278 (43.17%), Postives = 178/278 (64.03%), Query Frame = 2

Query: 1631 QIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPE 2464
            Q+G +V    +LK  K+  +V+ +Q EH +NE+ IL  +   F+VRL  +FKD   LYM++E   GGE++S LR    F E  ++FY A ++ A  YLHS  ++YRDLKPENLL+D QG+ ++TDFGFAK++  GR TWT CGTPEY+APEIIL+KG++   D W+LG+L++E+  G PPF A  P++IY  I+ G   + FP   S D ++L++ L + +  +R G  K GV + + H W  + +W  +    ++ P +P+   P D SNFD+Y  E
Sbjct:    2 QVGQHV----SLKATKRTKVVKLKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GR-TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFDDYEEE 271

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 204.527 bits (519), Expect = 3.800e-58
Identity = 126/344 (36.63%), Postives = 191/344 (55.52%), Query Frame = 2

Query: 1433 CLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALK--DLVVIATLGIGGFGRVELVQ-IGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYM-VQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKK-IGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFD 2449
            C   D   ++QL       Q   E   ND     LGPS    NL  K  D   +  LG G FG+V L +   D +   YA+K +KK  I++ ++++HIM ERN+L   V+  F+V LH +F+    LY +M+   GGEL+  L+ + +F E+  +FY A +  A+ YLHS  IVYRDLKPEN+LLD QG   +TDFG  K+ I     T TFCGTPEY+APE++    +D   D W LG +++E+L G+PPF + +  ++Y  IL     ++     +  A ++++ L   +P++R+G     + E + H++  + NW+ L +  I  P  P ++ P D  NFD
Sbjct:   48 CQNPDVRKFLQLDNPRNQTQGPME---NDADHINLGPSA---NLQAKPSDFDFLTVLGKGSFGKVLLAKHKSDGI--FYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILH--QPLQLRPCTTNAAISVLEGLLHKDPHQRLG-ATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFD 380

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 202.986 bits (515), Expect = 5.901e-57
Identity = 113/305 (37.05%), Postives = 167/305 (54.75%), Query Frame = 2

Query: 1544 SKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHS-RGIVYRDLKPENLLLDNQGFCKITDFGFAKK-IGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDE 2452
            SK    + + +   +  LG G FG+V LV+      + YA+K LKK  IV   +  H + E  +L   +  F+  L  +F+    L  +ME   GGEL+  L     F E+ T+FY A ++ AL YLH+ + +VYRDLK ENL+LD  G  KI DFG  K+ I  G    TFCGTPEY+APE++ +  +    D W LG++M+E++ G  PF   D  K++ +IL  ++ I FP+ +S DA+ L+  L + +P +R+G G    KE  +H +     W  +    + PP  PQ+ S TD   FDE
Sbjct:  139 SKPKSKVTMNNFDYLKLLGKGTFGKVILVR-EKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDE 440

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BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 255.373 bits (651), Expect = 2.630e-77
Identity = 135/318 (42.45%), Postives = 191/318 (60.06%), Query Frame = 2

Query: 1514 NDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPT-DCSNFDEYPPE 2464
            + LP++ L    +Y    L D  ++ TLG G FGRV LV+   N  + YA+K LKK  +V+ +Q EH  +ER +L +V+  F++R+  TF+D + ++M+M+   GGEL+S+LR    F     KFY A VI AL YLH+  I+YRDLKPEN+LLD  G  KITDFGFAK++     TWT CGTP+Y+APE+I  K ++   D WSLG+L++E+L G  PF    PMK Y  IL+G   + +P     D  +L+ KL   +   R+G  + G ++ + H W     W+ LL+  I+ P  P I S   D S FD+YP E
Sbjct:   52 SQLPQKSLVSKGKY---TLHDFQIMRTLGTGSFGRVHLVRSVHN-GRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV--QTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG--KVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYPEE 361

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BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 253.447 bits (646), Expect = 2.603e-76
Identity = 133/301 (44.19%), Postives = 184/301 (61.13%), Query Frame = 2

Query: 1565 ALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPT-DCSNFDEYPPE 2464
            +L D  ++ TLG G FGRV L++   N  + YALK LKKH IV+ +Q EH  +ER +L +V   FI+R+  TF+D + ++M+M+   GGEL+S+LR    F     KFY A V  AL YLHS+ I+YRDLKPEN+LLD  G  KITDFGFAK +     T+T CGTP+Y+APE++  K ++   D WS G+L++E+L G  PF   + MK Y  IL     ++FP     DAQ+L+KKL   + +ER+G  + G ++ + H W     W+ LL+  I+ P  P I     D S FD YP E
Sbjct:   84 SLSDFQILRTLGTGSFGRVHLIRSNHN-GRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNA--ELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEE 379

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BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 244.588 bits (623), Expect = 4.568e-73
Identity = 127/301 (42.19%), Postives = 184/301 (61.13%), Query Frame = 2

Query: 1565 ALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPT-DCSNFDEYPPE 2464
            +L+D  ++ TLG G FGRV L++   N  + YA+K LKK  +V  +Q EH  +ER +L +V   FI+R+  TF+D + ++M+M+   GGEL+S+LR    F     KFY A V  AL YLHS+ I+YRDLKPEN+LLD  G  KITDFGFAK +     T+T CGTP+Y+APE++  K ++   D WS GIL++E+L G  PF   + MK Y  IL     + FP   ++D ++L+ +L   + ++R+G  + G ++ + H W +   W+ LLS  I+ P  P I     D S FD+YP E
Sbjct:   83 SLQDFQILRTLGTGSFGRVHLIRSRHN-GRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA--ELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEE 378

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BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609])

HSP 1 Score: 220.32 bits (560), Expect = 1.349e-61
Identity = 121/305 (39.67%), Postives = 178/305 (58.36%), Query Frame = 2

Query: 1541 PSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAK-KIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDE 2452
            PS+  K L++ D  ++  +G G FG+V  V+  D  +K YALK ++K +IV   +  H + ER +L  V   FIV L  +F+  + LY ++    GGEL+  L+    FD +  +FYTA ++ AL  LH   +VYRDLKPEN+LLD QG   + DFG  K  +    KT TFCGTPEY+APE++L  G+    D W+LG+L++E+LTG+PP+   D  K+Y  IL+  + + FP    +DA++L+  L   +P  R+GY   G  E + H +    +W  LL     PP  P +++  D SNFDE
Sbjct:  336 PSRN-KPLSIDDFDLLKVIGKGSFGKVMQVRKKD-TQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQ--EPLVFPDGFDRDAKDLLIGLLSRDPTRRLGY--NGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDE 634

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710])

HSP 1 Score: 202.601 bits (514), Expect = 1.994e-55
Identity = 116/305 (38.03%), Postives = 174/305 (57.05%), Query Frame = 2

Query: 1541 PSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAK-KIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDE 2452
            PSK  K L++ D  ++  +G G FG+V  V+  D  +K YALK L+K +IV   +  H + ER +L  V   FIV L  +F+  + LY+++    GGEL+  L+    F    ++FY A ++ AL  LH   ++YRDLKPEN+LLD QG   + DFG  K  +    KT TFCGTPEY+APEI+L +G+    D W+LGIL++E++TG+PP+   +   +Y  IL+    + FP      A++L+  L   +P+ R+G    G  E + H + +  +W  LL     PP  P + S  D +NFD+
Sbjct:  333 PSKN-KPLSIDDFDLLKVIGKGSFGKVMQVRKKD-TQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQ--QPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV--NGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQ 631

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BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO38407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCZ7])

HSP 1 Score: 753.051 bits (1943), Expect = 0.000e+0
Identity = 378/627 (60.29%), Postives = 471/627 (75.12%), Query Frame = 2

Query:  653 SNERMKRIAISGE---SGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQR-TYED---GVN-DLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            S  R +R  IS E   +     S + L    K+ ++KELIK +IL+NDF+KNLE SQ++ +V+CM    F  +  IIKE E GS +YV+E+GK  V+KEG  L  M     FGELAILYNCTRTA+V A T  KLWAIDR +FQ+IMM+TGL++  E++ FL+SV + KDL ES L KI+ V+EET Y  G+YIIRQG +GDTFFII SG V +T++    + +     +R + +G +FGEKALK EDLRTAN IA    GV CLVLDRE+++Q IG+L  +QR  Y+D   GV+      +     E+ N+ L+DL V+ TLGIGGFGRVELVQ+  + K+T+ALK LKKHHIVETRQQ+HIM+E+ I+    S FIVRLH+TFKD+K+LYML+EVCLGGELW+ILRDR +FD++TT+FY  CVIEA  YLHS+GIVYRDLKPENLLLD  G+CK+ DFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHD  AD WSLGILM+ELLTG PPF+  DPMK YNIILKGID I+FP+KI+++A  LIKKLCRDNP ER+GY KGG+K+  KH W + FNWDGL S  +  PI P+I SP D SNFD+YP + ++PPDD++GWD+DF
Sbjct:   40 SRARNQRQGISAEPQSAKQVADSSKPLQRHPKNSRSKELIKEAILDNDFLKNLEASQVREVVECMCERMFKRDEYIIKEKEPGSHLYVLEEGKCQVTKEGTVLGHMGPGKAFGELAILYNCTRTASVRAQTSGKLWAIDRQTFQTIMMKTGLMRTAEHMEFLRSVNLLKDLAESYLLKIADVIEETFYEEGEYIIRQGARGDTFFIIKSGNVDITQRT---NVHSDPVHVRNLSKGAYFGEKALKGEDLRTANCIAG-KGGVTCLVLDREAFVQFIGNLDDIQRDQYDDSQRGVDPQTASHLRAQQDEFANVRLEDLTVVKTLGIGGFGRVELVQVAGD-KRTFALKTLKKHHIVETRQQDHIMSEKKIMMESNSPFIVRLHKTFKDKKYLYMLLEVCLGGELWTILRDRGSFDDSTTRFYVGCVIEAFQYLHSKGIVYRDLKPENLLLDGHGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFSGTDPMKTYNIILKGIDMIDFPRKITRNAHALIKKLCRDNPVERLGYQKGGLKDIMKHKWFDGFNWDGLRSRKLNSPIAPKIKSPVDASNFDDYPADDDIPPDDMTGWDKDF 661

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO38399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCY8])

HSP 1 Score: 671.774 bits (1732), Expect = 0.000e+0
Identity = 342/652 (52.45%), Postives = 458/652 (70.25%), Query Frame = 2

Query:  656 NERMKRIAISGESGTFIS----SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSL-QRTYED---GVN---DLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWL------------------ESFNWDGLLSHTIKPPIVP-----QINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            +++ KR A+SGES T       + + L  F K  ++K+LIK +I ENDF+KNLE +Q++ IVDCM    F  N +II+EG+ G+ +Y + DG++ V++E   L EM    VFGELAILYNC RTATVTA+   KLW IDR  FQ IMMRTG+++  E++ FLKSVP+ K+L  + L K++ VLE   Y  GDYIIR+  +GDTF+II+ G  +VT++ +   T  KE  IR++Q+G++FGEKAL  ED RTAN+IA +  GV+CLV+DR  ++ +IG++  L ++ Y D   G     D+P+E    SKE+ +L L+DL V+ATLG GGFGRVELV        TYALK LKK HI++TRQQEH+ +E+ IL    S FI +++RTFKDRK++YML+E CLGGELW+ILRDR  F++ T +F  ACV+E   YLHS+GIVYRDLKPENLLLD +G+ K+ DFGFAKKIG GRKTWTFCGTPEYVAPEIILNKGHD  +D WSLGIL+FELLTG PPF++ DPMK YNIIL+G+D +EFPK+I ++ QNLIK+LC+DNP ER+GY K G+ + +KH ++                  ++  W  L++ T+     P     ++ S TD SNFD Y  + ++PPD++SGWD +F
Sbjct:   17 SKKEKRQAVSGESSTKAQEESRTGKELERFPKDFRSKQLIKDAIFENDFLKNLEAAQVREIVDCMYSNTFQRNDVIIQEGDAGNALYAIADGRLQVTRENKVLGEMVAGMVFGELAILYNCRRTATVTAMEPTKLWKIDRRVFQIIMMRTGMIRQAEHMAFLKSVPLLKELPNAELSKLADVLEVDFYHAGDYIIRENERGDTFYIITKGSARVTQRIE-GQTGPKE--IRKLQKGDYFGEKALLSEDRRTANVIAEE-NGVECLVVDRTVFMTVIGNMDELREKDYGDEKRGAKRTLDVPEEERKVSKEFADLTLEDLEVVATLGTGGFGRVELV--------TYALKCLKKKHILDTRQQEHVYSEKRILMETNSPFICKIYRTFKDRKYVYMLLEACLGGELWTILRDRGTFEDATARFCIACVVEGFEYLHSKGIVYRDLKPENLLLDAKGYVKLVDFGFAKKIGSGRKTWTFCGTPEYVAPEIILNKGHDLSSDYWSLGILIFELLTGSPPFSSSDPMKTYNIILRGLDMVEFPKRIGRNPQNLIKRLCKDNPVERLGYQKDGLSDIKKHKYVVPWFPLAGTHRRDPRTSNQTRFW--LMTTTLSFKTSPIYLLIRVESSTDYSNFDVYSKDMDIPPDEMSGWDENF 654

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO35228 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM62])

HSP 1 Score: 268.47 bits (685), Expect = 2.862e-82
Identity = 139/307 (45.28%), Postives = 193/307 (62.87%), Query Frame = 2

Query: 1547 KEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKI-SKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPE 2464
            K+ K   L+D  +  TLG G FGRV L +      + YALK +    ++  +Q EH+ NE+NIL  ++  FIV L  T  D+ FLYML+E   GGEL++ LR    F+  T  F+ + ++ A+ YLH   IVYRDLKPEN+LLD  G  K+TDFGFAK++    KTWT CGTPEY+APEII +KGH+   D W+LGIL++E+L G PPF   +P  IY  IL G   +E+PK + +  A++LIKKL   +   R+G  K G ++ + H W +  +W+ +L   +KPPI P+I+ P D  NFD+YP E
Sbjct:    8 KKDKRTTLQDFELSKTLGTGTFGRVLLAR-DRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKEV--HDKTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKILSG--KVEWPKHMDNTSAKDLIKKLLVHDRTRRLGSMKNGSEDVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNFDDYPEE 309

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO31895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWM6])

HSP 1 Score: 228.794 bits (582), Expect = 7.335e-65
Identity = 124/303 (40.92%), Postives = 179/303 (59.08%), Query Frame = 2

Query: 1583 VIATLGIGGFGRVELVQ--IGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDD 2485
            ++  LG G FG+V LV+  IG +    YA+K LKK   ++ R +   M ER+IL  VQ  FIVRL+  F+    +Y++++   GG+L++ L     F E   KFY A +  AL +LH  GI+YRDLKPEN+LLD  G   +TDFG +K+    +KT++FCGT EY+APE++  +GH   AD WS G+LMFE+LTG  PF   D     N+ILK    +  P+ ++ +AQ+L+++L + NP  R+G G  G+++ +KH +  + NW+ L    IKPP  P      D   FD  P  T   P D
Sbjct:   11 LLKVLGQGSFGKVFLVRKVIGADAGTLYAMKVLKKA-TLKVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKA--KLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFFSTINWELLYKREIKPPFKPAAGRADDAFYFD--PEFTSKTPQD 308

HSP 2 Score: 97.0561 bits (240), Expect = 8.151e-21
Identity = 58/162 (35.80%), Postives = 89/162 (54.94%), Query Frame = 2

Query: 1760 IVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLL-DNQGF---CKITDFGFAKKIGFGRKT----WTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGI 2221
            IV L   ++  K +Y++ME+  GGEL   +       E         +   + +LH  G+V+RDLKP N++  D+ G     +I DFGFAK++   R T     T C T  +VAPE++  +G+D   D WSLG+L++ +L+G+ PF A  P    ++ILK I
Sbjct:  410 IVHLRDAYEAGKQVYIVMELMRGGELLDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQM---RATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPF-AVGPEDTPSVILKRI 567

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521])

HSP 1 Score: 217.238 bits (552), Expect = 1.785e-62
Identity = 125/314 (39.81%), Postives = 180/314 (57.32%), Query Frame = 2

Query: 1520 LPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQI--GDNVKKTYALKQLKKHHIVETRQQ-EHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRK-TWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFD 2449
            L +E + P  E   +  +   ++  LG GG+G+V LV+   G + +K +A+K LKK  I+ +++   H   ERNIL  V+  FIV L   F+    LY+++E   GGEL+  L     F E+T  FY + +  AL +LH +GIVYRDLKPEN+LLD  G  K+TDFG  K+  F    T TFCGT EY+APEI+   GH    D WSLG LM+++LTG PPF A +  K  + ILKG   +  P  ++ +A++ I+KL + +P  R+G   G     + H +     W+ LL+  ++PP  P I+   D S FD
Sbjct:   48 LSEETVNPKDE--KVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKG--KLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFD 357

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 802.742 bits (2072), Expect = 0.000e+0
Identity = 392/621 (63.12%), Postives = 478/621 (76.97%), Query Frame = 2

Query:  659 ERMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            +R KR AIS E   F     S   LP++ K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E ++FLKSVP F DL+E  L K++ VLEETHYA G+YIIRQG +GDTFFIIS GKV VTR++ P   N +  ++R + +G+WFGEKAL+ ED+RTA++IAA+   V CLV+DR+S+  LIG L  +     D   D   +    +  + +L L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SP D SNFD +P + E  PPDD SGWD DF
Sbjct:   70 QRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP---NGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAE--AVTCLVIDRDSFKHLIGGLEDVSSKGHDDA-DAKAKYEAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDDNSGWDVDF 684

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 765.377 bits (1975), Expect = 0.000e+0
Identity = 373/592 (63.01%), Postives = 458/592 (77.36%), Query Frame = 2

Query:  656 NERMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQIN 2422
             +R KR AIS E   F     S   LP++ K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E ++FLKSVP F DL+E  L K++ VLEETHYA G+YIIRQG +GDTFFIIS GKV VTR++ P   N +  ++R + +G+WFGEKAL+ ED+RTA++IAA+   V CLV+DR+S+  LIG L  +     D   D   +    +  + +L L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P ++
Sbjct:   69 QQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP---NGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAE--AVTCLVIDRDSFKHLIGGLEDVSSKGHDDA-DAKAKYEAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 654

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 752.281 bits (1941), Expect = 0.000e+0
Identity = 371/594 (62.46%), Postives = 456/594 (76.77%), Query Frame = 2

Query:  647 KLSNERMKRI-AISGESGTFIS-SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQIN 2422
            +L   R +R   IS E  T    S + L  + K   +K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E ++FLKSVP F DL+E  L K++ VLEETHYA G+YIIRQG +GDTFFIIS GKV VTR++ P   N +  ++R + +G+WFGEKAL+ ED+RTA++IAA+   V CLV+DR+S+  LIG L  +     D   D   +    +  + +L L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR +F+++TT+FYTACV+EA  YLHS+GI+YRDLKPENL+LD++G+ K+ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P ++
Sbjct:   51 QLIGPRTRRAQGISAEPQTHQDLSRQALRRYPKSDWSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP---NGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAE--AVTCLVIDRDSFKHLIGGLEDVSSKGHDDA-DAKAKYEAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 638

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 718.383 bits (1853), Expect = 0.000e+0
Identity = 370/622 (59.49%), Postives = 452/622 (72.67%), Query Frame = 2

Query:  659 ERMKRIAISGESGTFIS---SPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDR-SAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETE-MPPDDISGWDRDF 2509
            +R KR AIS E   F     S   LP++ K  ++K+LIK +IL+NDFMKNLE SQI+ IVDCM PV++  +S IIKEG+VGSLVYVMEDGKV V+KE   L  M    VFGELAILYNCTRTATV  +T+ KLWAIDR  FQ+IMMRTGL+K+ E ++FLKSVP F DL+E  L K++ VLEETHYA G+YIIRQG +GDTFFIIS GKV VTR++ P   N +  ++R + +G+WFGEKAL+ ED+RTA++IAA+   V CLV+DR+S+  LIG L  +     D   D   +    +  + +L L D  +I TLG+GGFGRVELVQ+  +  KT+A+K LKK HIV+TRQQEHI +E+ I+    SDFIVRL+RTFKD K+LYMLME CLGGELW+ILRDR  +F  NT  +   C      ++  +G        +NL+     F ++ DFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD  AD WSLGILMFELLTG PPF+ PDPMK YNIIL+GID IEFPKKI+K+A NLIKKLCRDNP ER+G  K GVK+ QKH W E FNW+GL   T+ PPI+P + SP D SNFD +P + E  PPDD SGWD DF
Sbjct:   70 QRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP---NGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAE--AVTCLVIDRDSFKHLIGGLEDVSSKGHDDA-DAKAKYEAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRHKSFKINTHIWIGRCCF-MFTFICIKGHSCPTPDQKNLI-----FLQV-DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDDNSGWDVDF 678

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: ENSORLT00000001302.2 (cGMP-dependent protein kinase 2 [Source:NCBI gene;Acc:101165996])

HSP 1 Score: 627.476 bits (1617), Expect = 0.000e+0
Identity = 301/615 (48.94%), Postives = 419/615 (68.13%), Query Frame = 2

Query:  737 KHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDL----------PKEILGPSKEYKNLA--------------LKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            K+  TK LI  +IL NDF+K LE   ++ +VDCM    ++   ++I+EG+ G+ +YV+ +G + V + G  L EM   T FGELAILYNC RTATV A+    +W ++R +FQ+IMM+T   +++E   FL+SV + K L E  LG+I   LE  ++  G+YIIR+G +G+TFFII+ G+V VT+ +   +   + Q I+ +  G++FGE+AL  ED+R+ANII  +     CLV+DR+++ Q++G    LQ   ++ V +L          P      S E + L+               ++L VIATLG+GGFGRVELV++ D  + T+ALK +KK H+V+TRQQ+HI +E+ IL    S FI+RL RTF+D K++YML+EVCLGGELW++LRD S F+E T +F   CV+EA  YLHS GI+YRDLKPENLLLD  G+ K+ DFGFAK+IG GRKTWTFCGTPEYVAPE+I+NKGHD  ADCWSLGIL+FELLTG PPF+  DP+KIY ++L GID ++FPK+I K   +LI++LC+ NP ER+G  K G+ + +KH W + FNW+GL    +  P+  ++  P D SNFD +PP +E  PD++SGWD+DF
Sbjct:  159 KNSDTKRLINEAILSNDFLKKLEPQHMREMVDCMYEKVYSEGQLVIQEGDAGNYLYVLAEGLLEVIQNGKLLGEMHPGTAFGELAILYNCKRTATVKAVLQSHIWTLERQTFQTIMMQTTQARHQEYFTFLRSVSLLKQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIAKGQVTVTQSS---EGFTQPQEIKTLGVGDYFGERALISEDVRSANIICNE-NDTQCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDERRHFLPHSQQSDSPEAQELSRLRERTARIPANQPFQELEVIATLGMGGFGRVELVKLKDE-ESTFALKCIKKKHVVDTRQQQHIYSEKKILQQTNSSFIIRLFRTFRDNKYIYMLLEVCLGGELWTVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAKQIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIYTMVLHGIDRVDFPKRIGKRPDDLIRRLCKLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRGPMDHSNFDMFPPNSEEAPDELSGWDKDF 768

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000016927.1 (SMESG000016927.1)

HSP 1 Score: 1598.18 bits (4137), Expect = 0.000e+0
Identity = 791/794 (99.62%), Postives = 791/794 (99.62%), Query Frame = 2

Query:  128 MISTIVSHKEENSSLSTLKIYDWTGPLSALLAGKKSAISQASSFRIMGTLRELQMNLRKKLKELKQRXXXXXXXXXXXXXXXXXXXNLQRQLDKYRSILQSPMQIKPQISSIYNEDFQLFTPNGDVSHDSSISTGEMLNSSQNNQVLCYNCGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            MISTIVSHKEENSSLSTLKIYDWTGPLSALLAGKKSAISQASSFRIMGTLRELQMNLRKKLKELKQRDSLIDELEEELDQKDLLIENLQRQLDKYRSILQSPMQIKPQISSIYNEDFQLFTPNGDVSHDSSISTGEMLNSSQNNQVLCYNCGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDT EKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVND PKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDN KKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF
Sbjct:    1 MISTIVSHKEENSSLSTLKIYDWTGPLSALLAGKKSAISQASSFRIMGTLRELQMNLRKKLKELKQRDSLIDELEEELDQKDLLIENLQRQLDKYRSILQSPMQIKPQISSIYNEDFQLFTPNGDVSHDSSISTGEMLNSSQNNQVLCYNCGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 794

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000016927.1 (SMESG000016927.1)

HSP 1 Score: 1236.48 bits (3198), Expect = 0.000e+0
Identity = 597/641 (93.14%), Postives = 608/641 (94.85%), Query Frame = 2

Query:  587 KLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            K Q  +  T  + N ++G    +  R++ + IS E  T   +     +F+K  KTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDT EKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVND PKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDN KKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF
Sbjct:   42 KYQSVFSATQKQNNVQSGPHN-NQTRVRGLGISAEPQTAKIANFQPSFFQKDSKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 681

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000005347.1 (SMESG000005347.1)

HSP 1 Score: 835.484 bits (2157), Expect = 0.000e+0
Identity = 402/646 (62.23%), Postives = 496/646 (76.78%), Query Frame = 2

Query:  575 NCGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEV-LPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            N GAKL ++   +   ++NK         R KR AISGES  ++++  + +   EK  K+KELI+ +I +ND+MK+L+ SQI  IV+CM PV +   S II+EGE+GS+VY +EDG V V+K G  +REM   TVFGELAILYNCTRTA+V A T+CKLWAIDR  FQSIMM+TGL K E+ + FLKSVP F+D+   TLGKI+GVL E HY+ GDYIIR+G KG TF+II  G+V+VT+K    D   +E FIR + RG WFGEKAL+DED+RTA+IIA  P+GVDCLVLDRESY  LIGD+ +  + Y D       +    + ++  LAL+DL VI TLG+GGFGRVELV+IG++ ++T+ALK LKK+HIVET QQEH+MNER+IL  V S+FIV+L++TFKDR++LYMLMEVCLGGE+W+ILR++ +FD+ TTKFYTA VI AL YLH +GIV+RDLKPEN LLD +G+CK+TDFGFAKKIGF RKTWTFCGTPEYVAPEIILNKGHD   D WSLGILM+EL TG PPFT+ DPMK YNIILKGI  I+F  KISK AQ+LIKKLCR+NP+ER+GYGK GV E QKH W E FNW+GLLS   KPPI+PQ+ S  D SNFD Y P+ E P +DISGWD+DF
Sbjct:  230 NFGAKLSVSVAKSTKTDSNK--------MRAKRNAISGESAKYLTTNGITMKRVEKPSKSKELIRSAIYDNDYMKHLDPSQITEIVECMSPVTYHEGSWIIQEGEIGSIVYALEDGLVEVTKSGAIIREMGPGTVFGELAILYNCTRTASVRATTECKLWAIDRQCFQSIMMKTGLRKQEDYIRFLKSVPTFQDMNMETLGKIAGVLGENHYSQGDYIIREGEKGATFYIIEKGRVKVTKKTSKSD---EEVFIRHLDRGSWFGEKALRDEDVRTASIIAESPSGVDCLVLDRESYNLLIGDIVNFDKQYPD-----EDKARRRASKFPELALRDLCVITTLGVGGFGRVELVRIGNDDRRTFALKVLKKYHIVETHQQEHVMNERDILMEVDSEFIVKLYKTFKDRRYLYMLMEVCLGGEVWTILREKVSFDDATTKFYTASVILALEYLHRKGIVFRDLKPENCLLDEKGYCKLTDFGFAKKIGFARKTWTFCGTPEYVAPEIILNKGHDFAVDIWSLGILMYELFTGTPPFTSSDPMKTYNIILKGIQTIDFSSKISKHAQSLIKKLCRENPSERLGYGKLGVAEAQKHAWFEGFNWEGLLSKKTKPPIIPQVKSAVDVSNFDLYSPDEETPAEDISGWDKDF 859

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000007783.1 (SMESG000007783.1)

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 310/630 (49.21%), Postives = 419/630 (66.51%), Query Frame = 2

Query:  662 RMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAAD-PAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDLPKEILGPSKEYKNLA-----------LKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDA--IEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            R KR+ ISGES       + L  F K  + K++I+++I+ N  +  L+ SQ+  I++CM       N  +I+EGE G  +YV ++G+  V K+   + +M N+  FGELA+LYNC RTA+V A+  C LW +DR  FQ+IMM+TGL + ++   FL+SV +F+ L E  L KI  ++E   Y++G  IIRQG + D+FFII +G V+VT+K   D+       +R+M  GE+FGEKAL +E  RTANI A   P  V CL   R+++ +LIG+L  LQ    D   D  +  +  S   +N A           L D  ++ATLG GGFGRVELV    +  K+YALK +KK +IV+T+QQ+H+M+E+ IL   +S +I RL+ TF D K++Y+L EVCLGGELW+ILRDR  FD+  T F  ACV+EAL YLHSRGIVYRDLKPENLL+ N G+ K+ DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD   D WS+GIL +ELL G PPF A DPMKIYN+ LKGI+   I    KI+  A +LI++LCR  P ER+G GK G++E + H + + F+W+G+ S T+K P  P+IN P D SNFD++  E+++PPD+ SGWD+DF
Sbjct:   98 RSKRLGISGESSNH-QRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCYVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE-----VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGELNVLQAKEYD---DESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITSFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPIDTSNFDKFTNESDIPPDENSGWDKDF 716

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000008788.1 (SMESG000008788.1)

HSP 1 Score: 592.038 bits (1525), Expect = 0.000e+0
Identity = 305/632 (48.26%), Postives = 415/632 (65.66%), Query Frame = 2

Query:  662 RMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGDLTSLQ-RTYEDG-------------VNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEF--PKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 2509
            R K+  +SGES    ++ +++ Y +K    K L++ SIL+N  + NL   Q+  +++ M   +      +I EGE G  +YV E G   V K    L  +     FGELA+LYNC RTA+V A+TD KLW +DR  FQ+IMMRTG+ + EE L FLKSVP+ K L E  L K+  +LE   +  G+ IIRQG   D FFII SG V+VT++      + +EQ IR +  GE+FGEKAL   + RTAN+ A + +  D L L R+ +++LIGDL  L+ + YED               ND   E L       N+ LKDL ++ TLG+GGFGRVELV++  + + TYALK +KK+HIV+T+QQ+H+++E+ IL   +S FI RL+ TFKD KF+YMLMEVCLGGELW+ LRD+  FD+  TKF   CV+EA  YLHSRGI+YRDLKPENLL+   G+ K+ DFGFAK+IG G++TWTFCGTPEYV+PEIILNK HD  +D WS+GIL +ELLTG PPFT  DPMKIY +ILKGI+A +    ++I+  A + I+ LC+ N  ER+G G GG++E + H + + F+W+ +    +  P  P++ S TD SNFD++  E E+PPD+ SGWD +F
Sbjct:  245 RSKKQGVSGESNKDQTNLKLIKY-KKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQR-----YDGEEQVIRTLTMGEYFGEKALLSAETRTANVYA-NSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHLLSKSSSKVSICNDAEMEKL------VNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEEF 863

The following BLAST results are available for this feature:

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
BLAST of cGMP-dependent protein kinase vs. TrEMBL
BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
BLAST of cGMP-dependent protein kinase vs. Planmine SMEST

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PRKG1	0.000e+0	63.61	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]
PRKG1	0.000e+0	63.47	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	47.76	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	47.76	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	47.01	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
egl-4	0.000e+0	52.47	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	52.47	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	52.47	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	52.47	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	52.47	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
for	0.000e+0	60.39	gene:FBgn0000721 transcript:FBtr0446099	[more]
for	0.000e+0	60.39	gene:FBgn0000721 transcript:FBtr0089310	[more]
for	0.000e+0	60.39	gene:FBgn0000721 transcript:FBtr0089312	[more]
for	0.000e+0	60.39	gene:FBgn0000721 transcript:FBtr0089304	[more]
for	0.000e+0	62.72	gene:FBgn0000721 transcript:FBtr0473363	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1b	0.000e+0	63.56	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1b	0.000e+0	64.50	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1a	0.000e+0	62.22	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]
prkg1b	0.000e+0	60.67	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
CR925795.1	0.000e+0	64.25	protein kinase cGMP-dependent 1b [Source:NCBI gene...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
camk4	0.000e+0	62.89	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	0.000e+0	62.89	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	0.000e+0	63.53	calcium/calmodulin-dependent protein kinase IV [So...	[more]
ptafr	0.000e+0	50.49	platelet activating factor receptor [Source:Xenbas...	[more]
camk4	0.000e+0	64.35	calcium/calmodulin-dependent protein kinase IV [So...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Prkg1	0.000e+0	63.45	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]
Prkg1	0.000e+0	63.31	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]
Prkg2	0.000e+0	47.47	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg2	0.000e+0	46.72	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg1	6.818e-163	61.68	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P00516\|KGP1_BOVIN	0.000e+0	63.80	cGMP-dependent protein kinase 1 OS=Bos taurus OX=9...	[more]
sp\|P0C605\|KGP1_MOUSE	0.000e+0	63.31	cGMP-dependent protein kinase 1 OS=Mus musculus OX...	[more]
sp\|Q13976\|KGP1_HUMAN	0.000e+0	63.47	cGMP-dependent protein kinase 1 OS=Homo sapiens OX...	[more]
sp\|O77676\|KGP1_RABIT	0.000e+0	63.15	cGMP-dependent protein kinase 1 OS=Oryctolagus cun...	[more]
sp\|Q03043\|KGP24_DROME	0.000e+0	60.39	cGMP-dependent protein kinase, isozyme 2 forms cD4...	[more]

BLAST of cGMP-dependent protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267FLY4	0.000e+0	65.48	cGMP-dependent protein kinase OS=Macrostomum ligna...	[more]
V3ZX54	0.000e+0	65.59	cGMP-dependent protein kinase OS=Lottia gigantea O...	[more]
A0A267FPA9	0.000e+0	63.72	cGMP-dependent protein kinase OS=Macrostomum ligna...	[more]
A0A267GV06	0.000e+0	63.72	cGMP-dependent protein kinase OS=Macrostomum ligna...	[more]
K1QUW8	0.000e+0	64.32	cGMP-dependent protein kinase OS=Crassostrea gigas...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1b	0.000e+0	62.36	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1a	0.000e+0	58.65	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]
prkg2	0.000e+0	47.93	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
ENSAMXT00000002114.2	0.000e+0	50.74	cGMP-dependent protein kinase 2-like [Source:NCBI ...	[more]
prkg2	0.000e+0	47.21	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000002200.1	2.546e-132	56.63	pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 ...	[more]
ENSPMAT00000002201.1	1.231e-107	50.00	pep scaffold:Pmarinus_7.0:GL479132:31244:36797:-1 ...	[more]
ENSPMAT00000001814.1	7.608e-77	43.17	pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gen...	[more]
ENSPMAT00000006766.1	3.800e-58	36.63	pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 g...	[more]
ENSPMAT00000008480.1	5.901e-57	37.05	pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
TPK2	2.630e-77	42.45	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK3	2.603e-76	44.19	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK1	4.568e-73	42.19	cAMP-dependent protein kinase catalytic subunit; p...	[more]
YPK1	1.349e-61	39.67	S/T protein kinase; phosphorylates, downregulates ...	[more]
YPK2	1.994e-55	38.03	Protein kinase similar to S/T protein kinase Ypk1p...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38407	0.000e+0	60.29	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38399	0.000e+0	52.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35228	2.862e-82	45.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31895	7.335e-65	40.92	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41166	1.785e-62	39.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1	0.000e+0	63.12	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
prkg1	0.000e+0	63.01	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
prkg1	0.000e+0	62.46	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
prkg1	0.000e+0	59.49	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
ENSORLT00000001302.2	0.000e+0	48.94	cGMP-dependent protein kinase 2 [Source:NCBI gene;...	[more]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000016927.1	0.000e+0	99.62	SMESG000016927.1	[more]
SMESG000016927.1	0.000e+0	93.14	SMESG000016927.1	[more]
SMESG000005347.1	0.000e+0	62.23	SMESG000005347.1	[more]
SMESG000007783.1	0.000e+0	49.21	SMESG000007783.1	[more]
SMESG000008788.1	0.000e+0	48.26	SMESG000008788.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30014787 ID=SMED30014787|Name=cGMP-dependent protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2801bp
CACCAATCATATCGCGCTAAATATTGTAAATACAGATTACGGAAGATTAT
ATCAGGATTTCAGCAAAATATTTTTACCATATTTGAAATTATTATTTCAA
AATCTTTGATATTTCGTCATTTGTTGTATGATTTCAACAATTGTGTCCCA
TAAAGAAGAAAACAGTTCTTTGAGCACTTTAAAAATCTACGACTGGACAG
GTCCATTGTCAGCTCTGTTAGCTGGGAAAAAATCCGCAATATCTCAAGCA
TCATCGTTCAGAATTATGGGAACTCTAAGGGAACTACAAATGAACCTGAG
AAAGAAATTGAAAGAATTAAAACAACGAGATTCATTGATTGATGAGCTGG
AAGAGGAATTGGATCAGAAAGATTTGTTAATTGAAAATCTTCAAAGACAA
TTGGATAAGTATCGGTCAATTTTACAGTCTCCGATGCAAATTAAGCCACA
AATCTCTTCGATTTATAATGAAGACTTCCAGTTATTCACACCGAACGGAG
ACGTCTCACACGATTCTTCAATATCTACGGGAGAAATGTTGAATAGCTCA
CAAAACAATCAGGTCTTATGCTATAATTGCGGTGCAAAATTGCAGCTTGC
CTACATTTATACCGATATCGAAGAAAACAATAAAAATGGCGATTTTAAAT
TGAGCAATGAACGAATGAAAAGGATCGCCATTTCCGGAGAATCAGGAACT
TTCATTTCATCACCTGAAGTTTTACCATATTTTGAGAAACATTTAAAAAC
AAAAGAGCTTATCAAACGGTCCATTTTAGAAAATGATTTCATGAAAAATC
TGGAACAAAGTCAAATAAAGATGATTGTTGACTGCATGAGACCGGTGAAA
TTCGCAGCAAACAGTATCATTATTAAGGAAGGGGAAGTAGGATCTTTAGT
TTACGTAATGGAAGATGGGAAGGTCAGTGTATCGAAAGAAGGCCACCATT
TACGGGAAATGAAAAATGAGACTGTGTTTGGAGAATTAGCTATTCTTTAC
AATTGCACTCGAACTGCAACGGTTACAGCCATTACTGATTGCAAATTGTG
GGCAATCGATCGGCACAGTTTTCAATCAATAATGATGAGGACTGGACTTT
TAAAATATGAAGAAAATTTAAATTTTTTAAAAAGTGTTCCAATTTTCAAA
GATCTGGAAGAAAGTACTCTAGGAAAAATTTCAGGAGTTCTTGAAGAGAC
CCATTACGCCAATGGAGACTACATAATTCGTCAAGGAACAAAAGGAGACA
CATTTTTTATAATATCATCGGGTAAGGTTCAGGTTACTAGGAAAAATAAG
CCCGATGATACAAACGAAAAAGAACAATTTATTCGACAAATGCAGCGTGG
AGAATGGTTTGGTGAAAAAGCTTTAAAAGATGAAGATTTACGAACTGCCA
ACATTATTGCTGCTGATCCAGCGGGAGTCGACTGCTTGGTTTTGGACAGA
GAATCCTACATTCAACTTATTGGAGATTTAACAAGTCTCCAGCGGACGTA
TGAGGATGGAGTTAACGATTTGCCAAAGGAAATTTTGGGACCTTCAAAAG
AATATAAGAATTTAGCTTTGAAGGATTTGGTCGTGATAGCTACTTTAGGA
ATCGGCGGATTTGGACGAGTAGAACTGGTCCAAATAGGAGATAACGTCAA
AAAGACTTATGCCCTGAAACAGCTCAAAAAACATCACATTGTGGAAACCC
GACAACAGGAGCATATTATGAATGAAAGGAACATTTTATATATGGTTCAA
TCAGATTTTATAGTAAGACTGCATAGAACATTCAAAGACAGAAAATTTCT
ATATATGTTGATGGAAGTTTGCTTAGGCGGTGAATTATGGTCAATTTTAA
GAGACCGAAGCGCATTCGATGAAAATACAACAAAGTTTTATACAGCATGT
GTTATAGAAGCTCTCCACTATTTACATTCAAGAGGAATCGTTTACAGAGA
TCTTAAACCAGAGAATCTCTTATTAGATAACCAAGGATTTTGTAAAATTA
CGGATTTTGGATTCGCTAAAAAAATCGGTTTCGGAAGGAAAACGTGGACA
TTTTGCGGAACACCGGAATACGTTGCTCCAGAAATTATTCTCAATAAAGG
TCATGATACTTATGCCGACTGTTGGTCTTTAGGGATATTAATGTTTGAAT
TGCTCACAGGAATGCCTCCTTTCACGGCACCGGATCCGATGAAAATTTAC
AACATAATTCTCAAAGGAATTGATGCCATTGAATTTCCAAAGAAAATCTC
TAAAGACGCCCAAAACCTAATCAAAAAGCTTTGCAGGGATAATCCAAATG
AAAGAGTGGGTTATGGAAAGGGTGGAGTTAAAGAGTGCCAAAAACATTTA
TGGTTAGAGTCTTTCAACTGGGATGGATTACTGTCTCACACAATCAAGCC
TCCAATAGTGCCCCAAATAAACTCACCAACTGACTGTAGTAATTTTGATG
AATACCCTCCAGAAACCGAAATGCCTCCAGATGATATTAGTGGTTGGGAT
CGGGACTTTTGATGTAGTCCATTGACGAGTATTCCAATCATTGAAATGTC
TTTGAAAGTGAACTTAGAGATCAGTTGTAGTGGAACTCTTCTTGTAAAAA
TCTAATTGCTTTCTCTTATATTGATTTATAAAAAAAACATTTTTTATGTT
AAATTTTATTTTTATTTTTGTCTTCGAATCTTATCATTTGAATGAGTGAA
TAAAATTATAAATATCTAAACTCCTTAAATGGCCATATATTTGTTTTAAT
TCTATCATGTGAGACGGATAAAATGGTGAGTGTTAATGGTCTTGTTAGGA
A

protein sequence of SMED30014787-orf-1

>SMED30014787-orf-1 ID=SMED30014787-orf-1|Name=SMED30014787-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=795bp
MISTIVSHKEENSSLSTLKIYDWTGPLSALLAGKKSAISQASSFRIMGTL
RELQMNLRKKLKELKQRDSLIDELEEELDQKDLLIENLQRQLDKYRSILQ
SPMQIKPQISSIYNEDFQLFTPNGDVSHDSSISTGEMLNSSQNNQVLCYN
CGAKLQLAYIYTDIEENNKNGDFKLSNERMKRIAISGESGTFISSPEVLP
YFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIK
EGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVT
AITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGK
ISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTNEKEQ
FIRQMQRGEWFGEKALKDEDLRTANIIAADPAGVDCLVLDRESYIQLIGD
LTSLQRTYEDGVNDLPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVEL
VQIGDNVKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHR
TFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLH
SRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVA
PEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDA
IEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDG
LLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000043	dorsal ventral margin of the whole animal
PLANA:0000101	muscle cell
PLANA:0000140	anterior region of the whole animal
PLANA:0003001	lateral region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR035014	STKc_cGK
IPR018490	cNMP-bd-like
IPR011009	Kinase-like_dom_sf
IPR002374	cGMP_dep_kinase
IPR000719	Prot_kinase_dom
IPR000961	AGC-kinase_C
IPR000595	cNMP-bd_dom
IPR014710	RmlC-like_jellyroll
IPR018488	cNMP-bd_CS
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004692	cGMP-dependent protein kinase activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0000166	nucleotide binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0030553	cGMP binding

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 47..98
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 569..763 e-value: 6.9E-109 score: 365.3
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 482..775 e-value: 6.9E-109 score: 365.3
None	No IPR available	GENE3D	G3DSA:1.20.5.170		coord: 48..101 e-value: 5.7E-19 score: 69.6
None	No IPR available	PANTHER	PTHR24353:SF68		coord: 47..111 coord: 171..794
None	No IPR available	PANTHER	PTHR24353	CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE	coord: 47..111 coord: 171..794
None	No IPR available	CDD	cd12086	DD_cGKI-beta	coord: 50..101 e-value: 6.12896E-15 score: 67.3672
IPR002374	cGMP-dependent kinase	PRINTS	PR00104	CGMPKINASE	coord: 434..443 score: 70.0 coord: 444..458 score: 32.12 coord: 380..389 score: 67.27 coord: 345..359 score: 66.67 coord: 419..428 score: 81.82
IPR002374	cGMP-dependent kinase	PIRSF	PIRSF000559	cGMP-dep_kinase	coord: 32..794 e-value: 0.0 score: 1019.8
IPR000961	AGC-kinase, C-terminal	SMART	SM00133	pkinase_C_6	coord: 744..794 e-value: 2.0E-10 score: 50.7
IPR000961	AGC-kinase, C-terminal	PROSITE	PS51285	AGC_KINASE_CTER	coord: 744..794 score: 12.438
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 484..743 e-value: 9.0E-85 score: 297.6
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 486..743 e-value: 4.1E-69 score: 232.9
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 484..743 score: 46.463
IPR000595	Cyclic nucleotide-binding domain	SMART	SM00100	cnmp_10	coord: 339..466 e-value: 3.0E-18 score: 76.6 coord: 221..334 e-value: 3.6E-26 score: 103.0
IPR000595	Cyclic nucleotide-binding domain	PFAM	PF00027	cNMP_binding	coord: 240..321 e-value: 8.1E-18 score: 64.3 coord: 358..448 e-value: 6.4E-16 score: 58.2
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 221..336 score: 33.921
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 339..465 score: 30.216
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 339..456 e-value: 4.36343E-25 score: 98.5521
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 221..328 e-value: 2.13457E-27 score: 105.101
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 338..470 e-value: 6.3E-37 score: 128.1
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 198..337 e-value: 2.4E-49 score: 168.5
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 604..616
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00888	CNMP_BINDING_1	coord: 248..264
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00889	CNMP_BINDING_2	coord: 284..301
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00889	CNMP_BINDING_2	coord: 411..428
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00888	CNMP_BINDING_1	coord: 366..382
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 490..514
IPR035014	cGMP-dependent protein kinase, catalytic domain	CDD	cd05572	STKc_cGK	coord: 490..750 e-value: 1.77491E-164 score: 474.406
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 328..454
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 199..321
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 472..784