Ptk7
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014748 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 20Note: Hover over icons to view figure legend
Homology
BLAST of Ptk7 vs. Ensembl Human
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:9618]) HSP 1 Score: 200.29 bits (508), Expect = 1.231e-51 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 657 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 937 HSP 2 Score: 90.8929 bits (224), Expect = 1.350e-17 Identity = 103/434 (23.73%), Postives = 161/434 (37.10%), Query Frame = 3
Query: 1512 NPVPIIEWTFQDKEIPKYDINSQKPP--PRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFP-PEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
P P ++W F+D E P N +PP R VF N L++ + + G Y G R +E T E D +P + C + E + ++W+ G + + H G L + GVY C +L R+Q + I T G +W TD + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D +Y+C A N+ + E + V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 251 QPPPSLQWLFED-ETPI--TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ---GQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPS--VWWEHAGVRLPT---HGRVYQKGHELVLANIAESDAGVYTCHAANLA----GQRRQDVNI--------------------------TVANGSSLPEW----VTD------------------NAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGE 612 HSP 3 Score: 69.707 bits (169), Expect = 4.142e-11 Identity = 72/292 (24.66%), Postives = 121/292 (41.44%), Query Frame = 3
Query: 1737 ADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI---NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPN----EILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVI-NKTIKLVVGEKPKILKITENQTIQEGSTLVLDCV-AGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNG-TLIIKNVALSDEAKYSCFATN 2582
A AE QP ++L C I W +DGTP++ + + + RNL + A PEH+G+Y C S + + + Q + A F + DV + ++ HC+ +++W +F D P PP+ + ++GSL+L V+ AG Y C + +I T+ L E + + E + GS + C+ G P P+V W+ + V+ T +V++ G L++ N+A SD Y+C A N
Sbjct: 135 ASEAEIQP-----QTQVTLRCHID---GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQW---LFED---ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIED---MPLFEPRVFTAGSEERVTCLPPKGLPEPSV-WWEHAGVRLPT------------HGRVYQKGHELVLANIAESDAGVYTCHAAN 395 HSP 4 Score: 59.6918 bits (143), Expect = 4.554e-8 Identity = 123/621 (19.81%), Postives = 213/621 (34.30%), Query Frame = 3
Query: 495 GVTGDGFYLKKSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVG----TRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSI--YEKQGTNVKLTCPWGVGSFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEV----TFPPEFADSAENQPLY-LNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWY-KLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSS 2276
G T K P++++ +G++ C + AP VY W ++ ++ RR+ S+L DR D G + C+A++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + L G T + L + H G Y C G+ S F L++ D++ L P + + YE+ + + + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F+ ++ V + KG P P + W +P + QK LV+ E+D G Y N AG R + I V + P D+A + DD+ + C +AS +A ++ K+E PE T VYQ G++ + C+ +G K I+W K DP + P I +GSLV+ V + +G Y C A +S
Sbjct: 26 GGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVY-WLLDGAPVQDTERRFA--QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDG-TPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSA-QPPPSLQWLFEDETPITNRSRPPHLRRATVFAN-----GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKG-----------------------LPEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTC----IASNGPQGQIRAHVQLTVAVFI----------TFKVE---PERTTVYQ------GHTAL-------------------------------LQCEAQGDPKPLIQWKGKDRILDPTK-------LGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNS 539
BLAST of Ptk7 vs. Ensembl Human
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:9618]) HSP 1 Score: 199.904 bits (507), Expect = 2.337e-51 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 747 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1027 HSP 2 Score: 122.865 bits (307), Expect = 2.339e-27 Identity = 169/799 (21.15%), Postives = 291/799 (36.42%), Query Frame = 3
Query: 495 GVTGDGFYLKKSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVG----TRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSI--YEKQGTNVKLTCPWGVGSFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPN-----EILSD--GSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAEN 2807
G T K P++++ +G++ C + AP VY W ++ ++ RR+ S+L DR D G + C+A++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + L G T + L + H G Y C G+ S F L++ D++ L P + + YE+ + + + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F+ ++ V + KG P P + W +P + QK LV+ E+D G Y N AG R + I V P + ++ L E LDC + +A P+ T V+ R Q +I + D EV K+G + + + WY+ + + P S V+ + E ++D G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D +Y+C A N+ + E + V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 26 GGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVY-WLLDGAPVQDTERRFA--QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDG-TPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQ-PPPSLQWLFEDETPITNRSRPPHLRRATVFAN-----GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKG-----------------------LPEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDC---------------------------------------LTQATPKPTVVW-------------YRNQMLI----------SEDSRFEVFKNGTL--RINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEE 703
BLAST of Ptk7 vs. Ensembl Human
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:9618]) HSP 1 Score: 199.519 bits (506), Expect = 2.664e-51 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 731 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011 HSP 2 Score: 99.3673 bits (246), Expect = 3.590e-20 Identity = 143/673 (21.25%), Postives = 248/673 (36.85%), Query Frame = 3
Query: 495 GVTGDGFYLKKSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVG----TRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSI--YEKQGTNVKLTCPWGVGSFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPV 2447
G T K P++++ +G++ C + AP VY W ++ ++ RR+ S+L DR D G + C+A++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + L G T + L + H G Y C G+ S F L++ D++ L P + + YE+ + + + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F+ ++ V + KG P P + W +P + QK LV+ E+D G Y N AG R + I V P + ++ L E LDC + A+ T + W ++ I+ ++N L+I + Y+C + S Q ++ + KL+F +E +K+ + C G K IKW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W D PV
Sbjct: 26 GGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVY-WLLDGAPVQDTERRFA--QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDG-TPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQ-PPPSLQWLFEDETPITNRSRPPHLRRATVFAN-----GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKG-----------------------LPEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDCLTQ--ATPKPT-VVWYRNQMLISEDSRFEVFKNG--TLRINSVEVYDGTWYRCMSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KDKPV 630 HSP 3 Score: 69.3218 bits (168), Expect = 5.023e-11 Identity = 72/292 (24.66%), Postives = 121/292 (41.44%), Query Frame = 3
Query: 1737 ADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI---NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPN----EILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVI-NKTIKLVVGEKPKILKITENQTIQEGSTLVLDCV-AGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNG-TLIIKNVALSDEAKYSCFATN 2582
A AE QP ++L C I W +DGTP++ + + + RNL + A PEH+G+Y C S + + + Q + A F + DV + ++ HC+ +++W +F D P PP+ + ++GSL+L V+ AG Y C + +I T+ L E + + E + GS + C+ G P P+V W+ + V+ T +V++ G L++ N+A SD Y+C A N
Sbjct: 135 ASEAEIQP-----QTQVTLRCHID---GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQW---LFED---ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIED---MPLFEPRVFTAGSEERVTCLPPKGLPEPSV-WWEHAGVRLPT------------HGRVYQKGHELVLANIAESDAGVYTCHAAN 395 HSP 4 Score: 67.3958 bits (163), Expect = 2.050e-10 Identity = 67/272 (24.63%), Postives = 115/272 (42.28%), Query Frame = 3
Query: 1848 KDGTPIAS-----YMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINS------DVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDG-SLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVL 2627
+D TPI + ++ + NG +L + + +P + G+Y+C + R II++A L I VF +++ KG + ++ W P + + + G LVL ++ + AG Y C A + + + + V P LK ++ ++EG LDC+ P PTV W+ + + LI S++ R +VFKNGTL I +V + D Y C ++ S+E V+VL
Sbjct: 261 EDETPITNRSRPPHLRRATVFANG-SLLLTQVRPRNAGIYRCIGQG-------QRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR-----------VYQKGHELVLANIAESDAGVYTCHAANLAGQR--RQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRN-----QMLI------SEDSRFEVFKNGTLRINSVEVYDGTWYRCM-SSTPAGSIEAQARVQVL 499 HSP 5 Score: 64.3142 bits (155), Expect = 1.808e-9 Identity = 104/476 (21.85%), Postives = 164/476 (34.45%), Query Frame = 3
Query: 1512 NPVPIIEWTFQDKEIPKYDINSQKPP--PRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFP-PEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKL--QFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQE-GSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKV-------LTPEEYS-----------------------KQKLGAHFNRG--------MVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAEN 2807
P P ++W F+D E P N +PP R VF N L++ + + G Y G R +E T E D +P + C + E + ++W+ G + + H G L + GVY C +L R+Q + I ++ D LE K G + C T+ K + WY+ +S+ E+ +G+L + SV+ Y C SS I ++ V EK K + Q E + C A G PT+ W G +L + +DN GTL V D Y+C A+N + V + V + PE + K K + G M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 251 QPPPSLQWLFED-ETPI--TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ---GQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPS--VWWEHAGVRLPT---HGRVYQKGHELVLANIAESDAGVYTCHAANLA----GQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSR---------FEVFKNGTLRINSVEVYDGTWYRC--MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW---ERADGSSLPEW---VTDNA-------GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEE 687
BLAST of Ptk7 vs. Ensembl Human
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:9618]) HSP 1 Score: 199.904 bits (507), Expect = 2.931e-51 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 795 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1075 HSP 2 Score: 111.694 bits (278), Expect = 5.894e-24 Identity = 107/432 (24.77%), Postives = 174/432 (40.28%), Query Frame = 3
Query: 1515 PVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAEN 2807
P P + W +P + QK LV+ E+D G Y N AG R + I V P + ++ L E LDC + A+ T + W ++ I+ ++N L+I + Y+C + S Q ++ + KL+F +E +K+ + C G K IKW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D +Y+C A N+ + E + V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 358 PEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDCLTQ--ATPKPT-VVWYRNQMLISEDSRFEVFKNG--TLRINSVEVYDGTWYRCMSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEE 751 HSP 3 Score: 69.3218 bits (168), Expect = 5.501e-11 Identity = 72/292 (24.66%), Postives = 121/292 (41.44%), Query Frame = 3
Query: 1737 ADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI---NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPN----EILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVI-NKTIKLVVGEKPKILKITENQTIQEGSTLVLDCV-AGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNG-TLIIKNVALSDEAKYSCFATN 2582
A AE QP ++L C I W +DGTP++ + + + RNL + A PEH+G+Y C S + + + Q + A F + DV + ++ HC+ +++W +F D P PP+ + ++GSL+L V+ AG Y C + +I T+ L E + + E + GS + C+ G P P+V W+ + V+ T +V++ G L++ N+A SD Y+C A N
Sbjct: 143 ASEAEIQP-----QTQVTLRCHID---GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQW---LFED---ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIED---MPLFEPRVFTAGSEERVTCLPPKGLPEPSV-WWEHAGVRLPT------------HGRVYQKGHELVLANIAESDAGVYTCHAAN 403
BLAST of Ptk7 vs. Ensembl Human
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:9618]) HSP 1 Score: 199.904 bits (507), Expect = 3.043e-51 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 787 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1067 HSP 2 Score: 143.28 bits (360), Expect = 1.328e-33 Identity = 172/793 (21.69%), Postives = 301/793 (37.96%), Query Frame = 3
Query: 495 GVTGDGFYLKKSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVG----TRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSI--YEKQGTNVKLTCPWGVGSFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAEN 2807
G T K P++++ +G++ C + AP VY W ++ ++ RR+ S+L DR D G + C+A++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + L G T + L + H G Y C G+ S F L++ D++ L P + + YE+ + + + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F+ ++ V + KG P P + W +P + QK LV+ E+D G Y N AG R + I V P + ++ L E LDC + + + W ++ I+ ++N L+I + Y+C + S Q ++ + KL+F +E +K+ + C G K IKW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D +Y+C A N+ + E + V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 26 GGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVY-WLLDGAPVQDTERRFA--QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDG-TPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQ-PPPSLQWLFEDETPITNRSRPPHLRRATVFAN-----GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKG-----------------------LPEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDCLTQ---ATPKPTVVWYRNQMLISEDSRFEVFKNG--TLRINSVEVYDGTWYRCMSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEE 743
BLAST of Ptk7 vs. Ensembl Celegans
Match: scd-2 (ALK tyrosine kinase receptor homolog scd-2 [Source:UniProtKB/Swiss-Prot;Acc:O76411]) HSP 1 Score: 120.939 bits (302), Expect = 4.008e-27 Identity = 87/285 (30.53%), Postives = 146/285 (51.23%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDY-VTKXXXXXXXXXXXXXXXXXXXWGDLKQFLR-CLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVT---PQLNVKISHLGLCRDI-YQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
R ++ +LG+G FG+V ++ + S+ ++C+E L T D V +L+GI E P ++ LEY E GDL F++ C ++ + N L + +C +A G + + VH+D+AARNIL+T PQ KI+ G+ ++I Y +EY++ +G + PI+W PPEA + ++ +SD+WSF V CWE+FS V+P RNEE++ +LT A++ ++P +++ C +RP F D+ +D
Sbjct: 973 RDSIERGRVLGRGNFGEVYYGEYSGVKLAVKMISRTFSASQASQSDFCNE-----ALCMGTFVDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECRPNQVSLNPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAKEITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLT-EGARL--------EYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQD 1243
BLAST of Ptk7 vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.398 bits (298), Expect = 6.548e-27 Identity = 91/274 (33.21%), Postives = 148/274 (54.01%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIV-LPLAKYRNEEILDILTLNNAKVQTMYSSLEQF---PSEC-SHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
+G+GEFG+V L + N + V VK L FHR++ +L + V +++G+C +P L I+EY E GDLK ++ L++ P + Q +++C Q+A G+ + VH+D+AARN LV + NVKI+ G+ R +Y EY++ +G+ + PIRWM EA+L K+S SDVW F VT WEIFS P + ++++++ N + + SL+Q P C S + I C + + RPSF ++ + ++
Sbjct: 533 IGQGEFGEVDLCQLENRK-------VAVKKLHGISQADEFSFHREIRVLGSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYI--LKN------PTIQTSQCISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVE-----NLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 786
BLAST of Ptk7 vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.013 bits (297), Expect = 7.198e-27 Identity = 91/274 (33.21%), Postives = 148/274 (54.01%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIV-LPLAKYRNEEILDILTLNNAKVQTMYSSLEQF---PSEC-SHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
+G+GEFG+V L + N + V VK L FHR++ +L + V +++G+C +P L I+EY E GDLK ++ L++ P + Q +++C Q+A G+ + VH+D+AARN LV + NVKI+ G+ R +Y EY++ +G+ + PIRWM EA+L K+S SDVW F VT WEIFS P + ++++++ N + + SL+Q P C S + I C + + RPSF ++ + ++
Sbjct: 503 IGQGEFGEVDLCQLENRK-------VAVKKLHGISQADEFSFHREIRVLGSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYI--LKN------PTIQTSQCISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVE-----NLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 756
BLAST of Ptk7 vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.013 bits (297), Expect = 7.198e-27 Identity = 91/274 (33.21%), Postives = 148/274 (54.01%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIV-LPLAKYRNEEILDILTLNNAKVQTMYSSLEQF---PSEC-SHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
+G+GEFG+V L + N + V VK L FHR++ +L + V +++G+C +P L I+EY E GDLK ++ L++ P + Q +++C Q+A G+ + VH+D+AARN LV + NVKI+ G+ R +Y EY++ +G+ + PIRWM EA+L K+S SDVW F VT WEIFS P + ++++++ N + + SL+Q P C S + I C + + RPSF ++ + ++
Sbjct: 503 IGQGEFGEVDLCQLENRK-------VAVKKLHGISQADEFSFHREIRVLGSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYI--LKN------PTIQTSQCISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVE-----NLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQ 756
BLAST of Ptk7 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7220200:7221186:1 gene:WBGene00020106.1 transcript:R151.1d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 109.383 bits (272), Expect = 1.557e-26 Identity = 65/190 (34.21%), Postives = 106/190 (55.79%), Query Frame = 3
Query: 3507 WGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
+GDLK +L+ ++ + + +K + ++ QIA GM ++ + +H+DLAARNILV +KIS G+ R Y + + + P+RW+ PEA+ N YS +SDVW+F V WEI + P +++IL+ LT + M LEQ P++CS ++K C ++ ++RPSF I I+
Sbjct: 20 YGDLKHYLQNMRKEKDSDSAIDSK-EFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLT------EGM--RLEQ-PAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIE 196
BLAST of Ptk7 vs. Ensembl Fly
Match: Nrk (gene:FBgn0020391 transcript:FBtr0087728) HSP 1 Score: 141.739 bits (356), Expect = 5.992e-34 Identity = 100/295 (33.90%), Postives = 151/295 (51.19%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCH-EFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCL----------QDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIF-PIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
E+L YPR ++ LG+G FG V ARA + + LV VK L + +F R+ LLA + + +LLG+C P L+ EY GDL +FLR QDR N +L + M A IA GM +S + VH+DLA RN L+ + VKI+ GL IY +Y++ EN F PIRWMP E++L NK+S++SDVW++ + WE+FS + P +EE++ + N + P + +++++C + P RP F +I+ I+
Sbjct: 432 EKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHL-----LQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGN---------VLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQ 712
BLAST of Ptk7 vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0087118) HSP 1 Score: 140.969 bits (354), Expect = 4.302e-33 Identity = 90/276 (32.61%), Postives = 155/276 (56.16%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHE--FHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCA-QIAKGMENISYIRCVHKDLAARNILVT---PQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSF 4052
R LQ LGKG FG+V +A R+ +DG++ + V +R +P E F ++ ++A+ + L+G+C + +P ++LE GDL++FLR ++R P P L + + CA +AKG + R +H+D+AARN L++ P VKI+ G+ RDIY+S+Y+ + G+ + PI+WMPPEA L ++ ++DVWSF + WE+FS P N ++++ L + ++ + P+EC + ++ C + P++RP+F
Sbjct: 1190 RDSLQLVNALGKGAFGEVYMALYRH-RDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLR--ENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVME-LVVRGGRLGS--------PTECPVSIYKVMADCWNPTPEDRPTF 1453
BLAST of Ptk7 vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0331926) HSP 1 Score: 140.969 bits (354), Expect = 4.302e-33 Identity = 90/276 (32.61%), Postives = 155/276 (56.16%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHE--FHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCA-QIAKGMENISYIRCVHKDLAARNILVT---PQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSF 4052
R LQ LGKG FG+V +A R+ +DG++ + V +R +P E F ++ ++A+ + L+G+C + +P ++LE GDL++FLR ++R P P L + + CA +AKG + R +H+D+AARN L++ P VKI+ G+ RDIY+S+Y+ + G+ + PI+WMPPEA L ++ ++DVWSF + WE+FS P N ++++ L + ++ + P+EC + ++ C + P++RP+F
Sbjct: 1190 RDSLQLVNALGKGAFGEVYMALYRH-RDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLR--ENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVME-LVVRGGRLGS--------PTECPVSIYKVMADCWNPTPEDRPTF 1453
BLAST of Ptk7 vs. Ensembl Fly
Match: otk (gene:FBgn0004839 transcript:FBtr0088028) HSP 1 Score: 137.502 bits (345), Expect = 3.324e-32 Identity = 86/254 (33.86%), Postives = 141/254 (55.51%), Query Frame = 3
Query: 3339 QSLVVVKSLMR-SEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNL------PYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIV-LPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECS-HTFLSIIKKCLSIDPQNRPSFTDISVSI 4073
+ LV+VK+L + + C EF RQLDLL V +L G+C E +P ++LEY +WGDLKQFL + N P LT Q + + QIA+GM+ I R H+DLA RN +++ + VK+S+ LC+D Y EY + + PIRW+ PE + +++Y+ +SD++++ V WE+F+ LP + NE+++ ++ SLE +E + + I+ C +P+ RPSF+ + ++
Sbjct: 780 EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQ---------RSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL 1024 HSP 2 Score: 111.694 bits (278), Expect = 2.839e-24 Identity = 87/330 (26.36%), Postives = 158/330 (47.88%), Query Frame = 3
Query: 1941 TGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKD-GNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGG----CCAKDKSSSKTSRS 2915
G YQC ++ ++ ++ + + +L+F+ + LE++ +HCK +G ++W + D N+ P VE + ++G+L+ ++V ++ GNY C A +S I +VV K + + +T ++G T+V+ C A GDP PT+ W D L +D ER + +NGTL I+NV + DE Y C N+ L E+ +V T + ++ ++ G + + ++I ++ A+ Y+VL++GL ++C +R R R L + + G + +P V N G C +K + SRS
Sbjct: 349 AGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVR----DGENTT-LPDHVE----VDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQG-TVVMHCQAIGDPKPTIQWDKD-------LKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGD-GFLVTRAVLITMTVALAYIVLVVGLMLWCRYR--RQARKARLNDLSTKEAGGD----QPDVAGNGKGSEQEPCLSKQHNGHSKSRS 654 HSP 3 Score: 72.0182 bits (175), Expect = 4.305e-12 Identity = 136/617 (22.04%), Postives = 233/617 (37.76%), Query Frame = 3
Query: 477 ISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPS-NNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQ-GVASPKISKENINWFFNGNSELPVGTRVQSDG-TLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFP----NIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFP----PEFADSAEN-----QPLYLNEDDSLSLDCKIKRMASED----TTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGN--MHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLC 2261
++L++ V ++ P ++ V E + V F+C + S + + Y W N I Y+ R + S LHI+ R D G Y CIA N +S S P KL V ++E + +L R E +LLKC AS + I W+ N + +L VQ D L I G Y C + AG++ S ++ + K L + N K+ W +F+ + +R G G E+ P ++ I G + S + + C +YE P+ KN I ++ ++G + ++L S IP + +S K + + LV+ K +N ++ + + AG + Q+E P P + E QP N L LD + ++ + T ++ W +DG + +H+ + NG L EH G Y C + +++ K + +E ++ G MHC+ G K I+W K + N+ + L +G+L +++VQ + G+Y C
Sbjct: 13 MALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVH--QIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLE-SASVQLLGSNRNE-------LLLKCHVEGASGDLEPLEIEWYRN-SEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRL------PRRKNEKMMESWDKQTFL-CRGKRGG----AAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTC-------------------LYEL------PDELKNQRIQLRWRKDGKLLRQVELGGS---------------------APIPGHSFDSGKD---ALLREDARLVLHK--QNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKN----LELDAVVAKVHCKAQGTPTPQVQWVRDGEN-TTLPDHVEVDANG-TLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGP---IETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERF-----RFLENGTLEIRNVQVEDEGSYGC 542
BLAST of Ptk7 vs. Ensembl Fly
Match: Ror (gene:FBgn0010407 transcript:FBtr0079978) HSP 1 Score: 130.568 bits (327), Expect = 1.565e-30 Identity = 89/270 (32.96%), Postives = 151/270 (55.93%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEP-NYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
LG+G FG V + + +Q ++ V +K+L + +F R+++L++ + + +LG+ + EP ++ EY GDL +FL +L L + + + QI++GM+ +S VH+DLAARN LV L VKIS GL RDIY S+Y++ +++ P+RWMP E++L K++ +SDVWSF V WEI+S + P + N+E+++++ + + + S+ P C S++ +C RP+FTDIS +K
Sbjct: 416 LGEGAFGKVY--KGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQL---EFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLI-----RSRQLLSA----PENCPTAVYSLMIECWHEQSVKRPTFTDISNRLK 671
BLAST of Ptk7 vs. Ensembl Zebrafish
Match: ptk7a (protein tyrosine kinase 7a [Source:ZFIN;Acc:ZDB-GENE-050522-216]) HSP 1 Score: 189.889 bits (481), Expect = 2.357e-48 Identity = 110/284 (38.73%), Postives = 177/284 (62.32%), Query Frame = 3
Query: 3231 RLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNP-NLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
+L +PR L T LGKGEFG+VLLA+A+ +D E +++V+VKSL + +F + D+ A+ V +LLGIC E+EP +I+EY + GDLKQ+LR + + + L+ QK+++C Q+A+GME++S R VHKDLAARN L++ + +K+S LGL +D+Y SEY+ ++ P+RW+P EAV ++ +S ++DVWSFAV WE+FS +P A ++++L+ L K+ P C ++ +C + P++R SF++I ++ D
Sbjct: 780 KLQFPRSNLHTITTLGKGEFGEVLLAKAKAAED-EEETVVLVKSLQTRDEQMQMDFRHECDMFAKLSHSNVARLLGICREVEPHYMIMEYTDMGDLKQYLRVSKSKDEKVKVQPLSTKQKVSVCLQVARGMEHLSNQRFVHKDLAARNCLISSKRQIKVSSLGLSKDVYSSEYYHYRQSYIPLRWLPSEAVFEDDFSTKTDVWSFAVLMWEVFSFGEMPYADLADDKVLEALQDGKLKLCP--------PQGCPSRVFKLMVRCWAASPKDRLSFSEICSALSD 1054 HSP 2 Score: 114.005 bits (284), Expect = 7.868e-25 Identity = 113/433 (26.10%), Postives = 182/433 (42.03%), Query Frame = 3
Query: 1563 YDINSQKPPPRVHVFRNRH-LVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATN-------NQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQ 2834
++ Q+ P VF+ H L+ D G Y NKAG + ++ + V PE+ + L E + L C + + ++ W ++ PI++ +NG L+I + +Y C +S + N Q ++ + +L+F + LE+NK+G + C KG I W + +D VE GSL +V + AGNY C A + E I ++L V EN T+ +G T VL C A GDP P + W K E+ KS R + NG+L+I +V+ D Y+C A N + L V E V L+ +E + K M++TI + V A+ Y+++++GL +C + RRN A+ L K D +
Sbjct: 351 WERAGQRVPDHGRVFQKGHDLIFSPTHGEDSGIYTCFAQNKAGQKKQELTVTVATKPEWVQKPVDS--QLEEGRAGFLHCHTR---ANPEPQVTWYRNLQPISAEDVRFKLFSNG-TLRINNVEVYDGHMYSC--ESRTEAGRVNAQARVFVLERLKFTPTPQAYQCLELNKEGFLQCSAKGRQTPTIHWMRTDGSD------MAVWVEQQR-----GSLHFTTVTRADAGNYTCLATNDQQGE-IRAVVQLTVAVYVVFKLKPENTTVYQGHTAVLHCQATGDPPPFIQW-------KKKDKFLEAGKS---RFQKMANGSLVIHDVSTEDTGSYTCIAGNSCNIAHTSAELYVVEKPVQHSLSDDEKTPYK--------MIQTIGLSVGAAVAYIIIVLGLMFYC-----KQRRN----AKRLQKGQDGDE 736 HSP 3 Score: 76.6406 bits (187), Expect = 2.088e-13 Identity = 48/205 (23.41%), Postives = 91/205 (44.39%), Query Frame = 3
Query: 489 VIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNL 1100
VI FY K P ++ G+ C + Y+W N E + + RR+L D L DR +D G + CIA +S+ ++ + W+E + + PE +++ + +++L+C P+ + WF +G+ ++ + + ++ + + S G YHC + AG++ S F LN+ DK+
Sbjct: 28 VIMAQAASFYFTKEPKPQDALHGRSAMLRCEVNDPQGVSYAWTQNGEPVTNSERRFL--DGGNLKFTAIDRTLDSGNFQCIASKNSTGEEERTAETSFNIKWLESGA-VSLKSPESVAEIQSSSQVILRCNIDGYPRPTN---RWFKDGSQITEKNYKINNKERSVTLLNASPDDNGLYHCCAKNAAGQVCSSDNFTLNIIDKSF 226 HSP 4 Score: 52.7582 bits (125), Expect = 3.869e-6 Identity = 117/553 (21.16%), Postives = 211/553 (38.16%), Query Frame = 3
Query: 708 DPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRV--QSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTC--PWGVGS-FVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAG---SRMRKFQIE-VTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYW-KKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHN-RQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKL-IFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKP 2330
D G+Y+C A+N++ + + ++ ++KPE +K + CQ A P + E +++ N + +RV S+G+L I + + G Y C+ P G S+ + +++ ++ ++TC P+G VW ++R G + G + KG L S Y C +K + V +A E+ + K V +++G G ++ + NP P + W + I D+ R +F N L I E D Y + +AG ++ R F +E + F P Q L LN++ L K ++ T I+W + DG+ +A ++E + G +L G Y C + E Q + + + N+ V+ +HC+ G I+W K F + S+ + +++GSLV+ V + G+Y C A +S + + + +L V EKP
Sbjct: 196 DNGLYHCCAKNAAGQVCSSDN---FTLNIIDKSFPQPLVKPEDLVVMK-NEEAVFHCQFTAEPMPAVE----WYHENELVANKSRVFILSNGSLLITQVKQRNTGLYKCVAQGPRGPPVSLEASLRIAEIEDMMAKQSRVFSADSLE-RVTCRAPYGHPQPEVW--WERAGQRVPDHG-----RVFQKGHDLIFSPTHGEDSGIYTCFAQNKAGQKKQELTVTVATKPEW--------VQKPVDSQLEEGRAGFLHCHTR------------ANPEPQVTWYRNLQPISAEDV-------RFKLFSNGTLRINNVEVYDGHMYSCESRTEAGRVNAQARVFVLERLKFTP---TPQAYQCLELNKEGFLQCSAKGRQ-----TPTIHWMRTDGSDMAVWVE----QQRG-SLHFTTVTRADAGNYTCLATNDQQGEIRAVVQLTVAVYVVFKLKPENTTVYQ--GHTAVLHCQATGDPPPFIQWKKKDKFLEAGKSR---------FQKMANGSLVIHDVSTEDTGSYTCIAGNSCN--IAHTSAELYVVEKP 679
BLAST of Ptk7 vs. Ensembl Zebrafish
Match: ntrk2a (neurotrophic tyrosine kinase, receptor, type 2a [Source:ZFIN;Acc:ZDB-GENE-010126-1]) HSP 1 Score: 149.828 bits (377), Expect = 2.674e-36 Identity = 92/280 (32.86%), Postives = 146/280 (52.14%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ G+C+E +P +++ EY GDL +FLR + D LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + +I
Sbjct: 495 RHNIVLKRELGEGAFGKVFLAECYNLSADQEKILVAVKTLKEASENARKDFHREAELLTNLQHEHIVTFYGVCVESDPLIMVFEYMMHGDLNKFLRAHGPDAVLMSDGQIQQQAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPKEVYDLMLGCWQREPHTRLNIKEI 765
BLAST of Ptk7 vs. Ensembl Zebrafish
Match: ntrk2a (neurotrophic tyrosine kinase, receptor, type 2a [Source:ZFIN;Acc:ZDB-GENE-010126-1]) HSP 1 Score: 149.828 bits (377), Expect = 3.039e-36 Identity = 92/280 (32.86%), Postives = 146/280 (52.14%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ G+C+E +P +++ EY GDL +FLR + D LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + +I
Sbjct: 491 RHNIVLKRELGEGAFGKVFLAECYNLSADQEKILVAVKTLKEASENARKDFHREAELLTNLQHEHIVTFYGVCVESDPLIMVFEYMMHGDLNKFLRAHGPDAVLMSDGQIQQQAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPKEVYDLMLGCWQREPHTRLNIKEI 761
BLAST of Ptk7 vs. Ensembl Zebrafish
Match: ntrk2b (neurotrophic tyrosine kinase, receptor, type 2b [Source:ZFIN;Acc:ZDB-GENE-010126-2]) HSP 1 Score: 147.517 bits (371), Expect = 1.579e-35 Identity = 92/280 (32.86%), Postives = 149/280 (53.21%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
RH + + LG+G FG V LA N+ + + LV VK+L + + +FHR+ +LL + +++ K G+C+E +P +++ EY + GDL +FLR + D L LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ +++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + +I
Sbjct: 510 RHNILLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEI 780
BLAST of Ptk7 vs. Ensembl Zebrafish
Match: insra (insulin receptor a [Source:ZFIN;Acc:ZDB-GENE-020503-3]) HSP 1 Score: 149.058 bits (375), Expect = 1.752e-35 Identity = 92/277 (33.21%), Postives = 147/277 (53.07%), Query Frame = 3
Query: 3243 PRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCH-EFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
PR ++ LG+G FG V ++I GESQ+ V VK++ S EF + ++ C +V +LLG+ + +P L+++E GDLK FLR L+ NP P T + + M A+IA GM ++ + VH+DLAARN +V L VKI G+ RDIY+++Y+ + G+ + P+RWM PE++ ++ SD WSF V WE+ + P NE++L + M P C+ ++++ C +P+ RP+F +I
Sbjct: 990 PREKITLLRELGQGSFGMVYEGNGKDIVKGESQTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTHGDLKSFLRSLRPDSENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEVSTLAEQPYQGLSNEQVLKFV---------MEGGYLDRPDNCADRLHNLMQMCWHYNPKMRPTFQEI 1257
BLAST of Ptk7 vs. Ensembl Xenopus
Match: dcakd (dephospho-CoA kinase domain containing [Source:Xenbase;Acc:XB-GENE-1003179]) HSP 1 Score: 149.828 bits (377), Expect = 1.626e-36 Identity = 98/281 (34.88%), Postives = 153/281 (54.45%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPY--LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
R ++ + LG+G FG V LA N+ ++LV VK+L + N +F R+ +LL + +++ K G+C + EP +++ EY + GDL +FLR + D N PY L Q + + +QIA GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K++ +SD+WSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R + +I
Sbjct: 369 RRDIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVKALKEATENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDAKILDNGNGQ-PYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGR--------QLER-PRTCPTEVYNIMQGCWQREPQQRLNIKEI 639
BLAST of Ptk7 vs. Ensembl Xenopus
Match: ntrk2 (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:780110]) HSP 1 Score: 148.673 bits (374), Expect = 2.477e-36 Identity = 93/280 (33.21%), Postives = 149/280 (53.21%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ K G+C+E +P +++ EY + GDL +FLR + + P LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + +I
Sbjct: 321 RHNIVLKRELGEGAFGKVFLAECYNLYPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRP--AELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEI 589
BLAST of Ptk7 vs. Ensembl Xenopus
Match: dcakd (dephospho-CoA kinase domain containing [Source:Xenbase;Acc:XB-GENE-1003179]) HSP 1 Score: 149.828 bits (377), Expect = 3.069e-36 Identity = 98/281 (34.88%), Postives = 153/281 (54.45%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPY--LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
R ++ + LG+G FG V LA N+ ++LV VK+L + N +F R+ +LL + +++ K G+C + EP +++ EY + GDL +FLR + D N PY L Q + + +QIA GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K++ +SD+WSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R + +I
Sbjct: 447 RRDIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVKALKEATENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDAKILDNGNGQ-PYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQG--------RQLER-PRTCPTEVYNIMQGCWQREPQQRLNIKEI 717
BLAST of Ptk7 vs. Ensembl Xenopus
Match: dcakd (dephospho-CoA kinase domain containing [Source:Xenbase;Acc:XB-GENE-1003179]) HSP 1 Score: 149.058 bits (375), Expect = 5.969e-36 Identity = 98/281 (34.88%), Postives = 153/281 (54.45%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPY--LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
R ++ + LG+G FG V LA N+ ++LV VK+L + N +F R+ +LL + +++ K G+C + EP +++ EY + GDL +FLR + D N PY L Q + + +QIA GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K++ +SD+WSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R + +I
Sbjct: 470 RRDIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVKALKEATENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDAKILDNGNGQ-PYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGR--------QLER-PRTCPTEVYNIMQGCWQREPQQRLNIKEI 740
BLAST of Ptk7 vs. Ensembl Xenopus
Match: dcakd (dephospho-CoA kinase domain containing [Source:Xenbase;Acc:XB-GENE-1003179]) HSP 1 Score: 149.058 bits (375), Expect = 8.737e-36 Identity = 98/281 (34.88%), Postives = 153/281 (54.45%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPY--LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
R ++ + LG+G FG V LA N+ ++LV VK+L + N +F R+ +LL + +++ K G+C + EP +++ EY + GDL +FLR + D N PY L Q + + +QIA GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K++ +SD+WSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R + +I
Sbjct: 519 RRDIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVKALKEATENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDAKILDNGNGQ-PYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGR--------QLER-PRTCPTEVYNIMQGCWQREPQQRLNIKEI 789
BLAST of Ptk7 vs. Ensembl Mouse
Match: Ptk7 (PTK7 protein tyrosine kinase 7 [Source:MGI Symbol;Acc:MGI:1918711]) HSP 1 Score: 198.364 bits (503), Expect = 5.459e-51 Identity = 115/286 (40.21%), Postives = 181/286 (63.29%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
+R+ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R++++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C+Q+A GME++S R VHKDLAARN L++ Q VK+S LGL +D+Y SEY+ + P+RWM PEAVL+ +S +SDVW+F V WE+F+ +P ++E+L A +Q + L Q P C ++++C + +P++RPSF++I+ ++ D
Sbjct: 779 DRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTK-QKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL-------ADLQAGKARLPQ-PEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGD 1055 HSP 2 Score: 140.969 bits (354), Expect = 4.532e-33 Identity = 170/782 (21.74%), Postives = 298/782 (38.11%), Query Frame = 3
Query: 525 KSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNG---NSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSIYEKQGTNVKLTCPWGVG---SFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
K P++++ +G++ C + AP VY W +N ++ RR+ S+L DR D G + C+A+++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + + T + L + S H G Y C + G+ S F L++ D++ L P + + + C + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F ++ V +G P P + W +P + RVH + LV E+D G Y N AG R + I V P + ++ L E L C + A+ T I+++ + S NG L+I + +Y+C + S Q ++ + KL+F +E +K+ + C G K +KW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D Y+C A N+ + E ++ V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 28 KEPSSQDALQGRRALLRCEVEAPDPVHVY-WLLNGVPVQDTERRFA--QGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNE--EAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFAN-----GSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQG-----------------------LPTPSVWWEHAGVPLPAHG--------RVHQ-KGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDS--QLEEGKPGYLHCLTQ--ATPKPTVIWYRNQM--LISEDSRFEVSKNG-TLRINSVEVYDGTLYRCVSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNEPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGE 734
BLAST of Ptk7 vs. Ensembl Mouse
Match: Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1 [Source:MGI Symbol;Acc:MGI:97383]) HSP 1 Score: 154.836 bits (390), Expect = 9.664e-38 Identity = 98/285 (34.39%), Postives = 151/285 (52.98%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
R ++ + LG+G FG V LA N+ + + + LV VK+L + N +F R+ +LL + ++ + G+C E P L++ EY GDL +FLR L + L GQ + + +Q+A GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K+S +SDVWSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R S D+ ++
Sbjct: 510 RQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKEASENARQDFQREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGR--------ELER-PRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQ 785
BLAST of Ptk7 vs. Ensembl Mouse
Match: Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2 [Source:MGI Symbol;Acc:MGI:97384]) HSP 1 Score: 151.369 bits (381), Expect = 1.141e-36 Identity = 95/285 (33.33%), Postives = 151/285 (52.98%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ K G+C+E +P +++ EY + GDL +FLR L NP LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + I +++
Sbjct: 534 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE-LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQN 808
BLAST of Ptk7 vs. Ensembl Mouse
Match: Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2 [Source:MGI Symbol;Acc:MGI:97384]) HSP 1 Score: 151.369 bits (381), Expect = 1.141e-36 Identity = 95/285 (33.33%), Postives = 151/285 (52.98%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ K G+C+E +P +++ EY + GDL +FLR L NP LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + I +++
Sbjct: 534 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE-LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQN 808
BLAST of Ptk7 vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 151.369 bits (381), Expect = 1.710e-36 Identity = 98/292 (33.56%), Postives = 155/292 (53.08%), Query Frame = 3
Query: 3240 YPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMR-SEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRT----------------NPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
YPR+ ++ +G+G FG V ARA + E ++V VK L + + +F R+ L+A + + KLLG+C +P L+ EY +GDL +FLR + T +P P L+ +++ + Q+A GM +S + VH+DLA RN LV + VKI+ GL R+IY ++Y++ DG + PIRWMPPE++ N+Y+ +SDVW++ V WEIFS + P +EE++ + N + P C ++++ C S P +RPSF I
Sbjct: 569 YPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGN---------ILACPENCPLELYNLMRLCWSKLPADRPSFCSI 851 HSP 2 Score: 71.2478 bits (173), Expect = 8.410e-12 Identity = 68/275 (24.73%), Postives = 114/275 (41.45%), Query Frame = 3
Query: 1833 KIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIK-SLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQK 2654
+I W ++ I + S NG+ L I + G+Y C +G + ++ +K K+ IN + + + C T G K ++ W K NS+ +L GSL + +VQK+ AG Y C AK+S+ +K +KL V +IL+ E+ + GS + L C A G P PT+SW ++ ++ S + + + + L I L Y+C ATN ++ E+SK +
Sbjct: 58 EISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLK--AVLPCTTMGNPKPSVSWIKGDNALRENSRIA---------VLESGSLRIHNVQKEDAGQYRCVAKNSL-GTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISW-----IENGNAVSSGSIQESVKDRVIDSRLQLFITKPGL-----YTCIATNKHGEKFSTAKAAATVSIAEWSKSQ 310
BLAST of Ptk7 vs. UniProt/SwissProt
Match: sp|Q91048|PTK7_CHICK (Inactive tyrosine-protein kinase 7 OS=Gallus gallus OX=9031 GN=PTK7 PE=2 SV=1) HSP 1 Score: 202.986 bits (515), Expect = 1.379e-51 Identity = 113/285 (39.65%), Postives = 181/285 (63.51%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPY-LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
+++ +PR LQT LG+GEFG+V LA+A+ +D E ++LV+VKSL + +F R+ ++ + V +LLG+C E EP ++LEY + GDLKQFLR + + P L+ K+++C Q+A GME++S R VH+DLAARN LV+ Q VK+S L L +D+Y SEY+ + P+RWMPPEAVL++++S +SDVWSF V WE+F+ +P A ++E+L A +++ + L Q P C ++++C + P++RPSF++++ ++ D
Sbjct: 768 DKMHFPRSNLQTITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQTRDEQLQLDFRREAEMFGKLNHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDESLKPQPLSTKHKVSLCTQVALGMEHLSNGRFVHRDLAARNCLVSAQRQVKVSALSLSKDVYNSEYYHFRQAWIPLRWMPPEAVLEDEFSTKSDVWSFGVLMWEVFTQGEMPYAPLADDEVL-------AGLKSGKTKLPQ-PEGCPSRLTKLMQRCWAPSPKDRPSFSELAAALGD 1044 HSP 2 Score: 143.665 bits (361), Expect = 4.046e-33 Identity = 176/767 (22.95%), Postives = 297/767 (38.72%), Query Frame = 3
Query: 519 LKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS----DGTLHIESISISHFGFYHCLILHPA-GKMDSITPFILNLNDKNLNPTNFSIYEK----QGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSES-FPNIEIKGGTLTISQLDSSGDSYYLC-QDADKIKARVAVFRVYLAKMYE---FKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRN-RHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKS-----LGYSEFHNRQQKIIIKAKLQFIGINSDV-FLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFC 2756
K P +++ G+ C ++ + W N I+ +R+ + S L DR D G + C+A+N + ++ + WME +++ +P +++ + ++L+C P+ + + WF +G + LP G S + TL + G Y+C A G + S F LN+ D++ P + E + C + ++ P+T + F N G+L I+Q+ + Y C K KA V + LA++ E F + + N V +G P P + W + N ++ P V++ LV E D G Y NKAG + ++ I V P++ + ++ L E L C K AS T + W ++G I+ EN L+I + +Y+C + GY+ H + KL+F + +E NK+ + C G K I+W K + P V ILS V + +GNY C A +S E I T++LVV E T+ +G T + C A GDP P + W +GK I S R ++ NG+L+I +V D KY+C A N+ + E + V P + +H M++TI + V A+ Y+++++GL +C
Sbjct: 21 FAKEPYSQDALHGRSAILRCEVEEPAHVEFEWLQNGLPIQDTEQRF--KEGSNLQFAAVDRHRDAGSFQCVARNVQTGEEARTANASFNIKWMETG-SVVLKQPASAAEIQPSSTVVLRCHIDGHPRPTWQ---WFRDG-APLPDGRGTYSVSSKERTLTLRGAGPDDNGLYYCSARPRAVGSVCSQDNFTLNIIDESF-PQAVVVPEDLIVTKNEEAMFDCQFAAVPPPTQEWLFEDSPITNRSKTTVFAN-----GSLLITQVKARSTGVYKCIGHGQKGKALVLKATLRLAEIEEMAPFSPKVLTANQGHRVSCACPRG-----------------------VPTPQVWW----------ERNQERVPTAGRVYQEAEQLVFTSITEADAGIYTCHAANKAGEKKQELSITVATVPKWVEMPKDS--QLEESKPGYLHCLSK--ASLKPT-VTWYRNGVSISEDSRFEISENG--TLRINNVEVYDGTMYKCVSSTPAGSIEGYARVH-------VLEKLKFTPPPQPLQCMEFNKEVTVSCSATGREKPTIQWTKT------DGSSLPSHVSHRAGILS-----FHKVSRSDSGNYTCIASNSPQGE-IRATVQLVVAVYVTFKLEPEPTTVYQGHTAMFQCQAEGDPVPHIQW------KGKDKILDPSKLLP--RIQIMPNGSLVIYDVTTEDSGKYTCIAGNSCNIKHREAFLYVVDKPAAEEDEGPSSHTPYKMIQTIGLSVGAAVAYIIIVLGLMFYC 707
BLAST of Ptk7 vs. UniProt/SwissProt
Match: sp|Q13308|PTK7_HUMAN (Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2) HSP 1 Score: 199.519 bits (506), Expect = 1.881e-50 Identity = 113/290 (38.97%), Postives = 181/290 (62.41%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+++ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R+L++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C Q+A GME++S R VHKDLAARN LV+ Q VK+S LGL +D+Y SEY+ + P+RWM PEA+L+ +S +SDVW+F V WE+F+ +P ++E+L L A++ P C ++++C ++ P++RPSF++I+ ++ D +++
Sbjct: 787 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK-QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ--------PEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1067 HSP 2 Score: 111.309 bits (277), Expect = 4.376e-23 Identity = 107/432 (24.77%), Postives = 174/432 (40.28%), Query Frame = 3
Query: 1515 PVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAEN 2807
P P + W +P + QK LV+ E+D G Y N AG R + I V P + ++ L E LDC + A+ T + W ++ I+ ++N L+I + Y+C + S Q ++ + KL+F +E +K+ + C G K IKW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D +Y+C A N+ + E + V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 350 PEPSVWWEHAGVRLPTHGRVYQK---------GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDCLTQ--ATPKPT-VVWYRNQMLISEDSRFEVFKNG--TLRINSVEVYDGTWYRCMSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNGPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEE 743 HSP 3 Score: 68.9366 bits (167), Expect = 3.311e-10 Identity = 72/292 (24.66%), Postives = 121/292 (41.44%), Query Frame = 3
Query: 1737 ADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI---NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPN----EILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVI-NKTIKLVVGEKPKILKITENQTIQEGSTLVLDCV-AGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNG-TLIIKNVALSDEAKYSCFATN 2582
A AE QP ++L C I W +DGTP++ + + + RNL + A PEH+G+Y C S + + + Q + A F + DV + ++ HC+ +++W +F D P PP+ + ++GSL+L V+ AG Y C + +I T+ L E + + E + GS + C+ G P P+V W+ + V+ T +V++ G L++ N+A SD Y+C A N
Sbjct: 135 ASEAEIQP-----QTQVTLRCHID---GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQW---LFED---ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIED---MPLFEPRVFTAGSEERVTCLPPKGLPEPSV-WWEHAGVRLPT------------HGRVYQKGHELVLANIAESDAGVYTCHAAN 395
BLAST of Ptk7 vs. UniProt/SwissProt
Match: sp|Q8BKG3|PTK7_MOUSE (Inactive tyrosine-protein kinase 7 OS=Mus musculus OX=10090 GN=Ptk7 PE=1 SV=1) HSP 1 Score: 198.364 bits (503), Expect = 3.818e-50 Identity = 115/286 (40.21%), Postives = 181/286 (63.29%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
+R+ +PR LQ LGK EFG+V LA+A+ +++G +++LV+VKSL + +F R++++ + V +LLG+C E EP ++LEY + GDLKQFLR + D + P TK QK+ +C+Q+A GME++S R VHKDLAARN L++ Q VK+S LGL +D+Y SEY+ + P+RWM PEAVL+ +S +SDVW+F V WE+F+ +P ++E+L A +Q + L Q P C ++++C + +P++RPSF++I+ ++ D
Sbjct: 779 DRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTK-QKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL-------ADLQAGKARLPQ-PEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGD 1055 HSP 2 Score: 140.969 bits (354), Expect = 3.170e-32 Identity = 170/782 (21.74%), Postives = 298/782 (38.11%), Query Frame = 3
Query: 525 KSPTNKEVEEGKKVSFDC-LAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNG---NSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-----LNPTNFSIYEKQGTNVKLTCPWGVG---SFVW-----SKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
K P++++ +G++ C + AP VY W +N ++ RR+ S+L DR D G + C+A+++ + +S + W+E +++ P +++ ++ L+C P+ + + WF +G + + T + L + S H G Y C + G+ S F L++ D++ L P + + + C + S W + P L + F N G+L ++Q+ Y C Q I + + M F+ F ++ V +G P P + W +P + RVH + LV E+D G Y N AG R + I V P + ++ L E L C + A+ T I+++ + S NG L+I + +Y+C + S Q ++ + KL+F +E +K+ + C G K +KW + + P+ V + G+L V +D AGNY C A + + I ++L V E T+ +G T +L C A GDP P + W +GK I + TK R +F+NG+L+I +VA D Y+C A N+ + E ++ V P + G+ M++TI + V A+ Y++ ++GL +C R R + E
Sbjct: 28 KEPSSQDALQGRRALLRCEVEAPDPVHVY-WLLNGVPVQDTERRFA--QGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAG-PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ---WFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNE--EAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFAN-----GSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQG-----------------------LPTPSVWWEHAGVPLPAHG--------RVHQ-KGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDS--QLEEGKPGYLHCLTQ--ATPKPTVIWYRNQM--LISEDSRFEVSKNG-TLRINSVEVYDGTLYRCVSSTPAGS--IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRA------DGSSLPEWV-----TDNAGTLHFARVTRDDAGNYTCIASNEPQGQ-IRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQW------KGKDRI-LDPTKL-GPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGE 734
BLAST of Ptk7 vs. UniProt/SwissProt
Match: sp|P35739|NTRK1_RAT (High affinity nerve growth factor receptor OS=Rattus norvegicus OX=10116 GN=Ntrk1 PE=1 SV=1) HSP 1 Score: 157.532 bits (397), Expect = 9.427e-38 Identity = 99/285 (34.74%), Postives = 152/285 (53.33%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
R ++ + LG+G FG V LA N+ + + + LV VK+L + N +FHR+ +LL + ++ + G+C E P L++ EY GDL +FLR L + L GQ + + +Q+A GM ++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE++L K+S +SDVWSF V WEIF+ P + N E ++ +T LE+ P C +I++ C +PQ R S D+ ++
Sbjct: 510 RQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGR--------ELER-PRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQ 785
BLAST of Ptk7 vs. UniProt/SwissProt
Match: sp|P14616|INSRR_HUMAN (Insulin receptor-related protein OS=Homo sapiens OX=9606 GN=INSRR PE=1 SV=2) HSP 1 Score: 156.762 bits (395), Expect = 5.899e-37 Identity = 95/283 (33.57%), Postives = 153/283 (54.06%), Query Frame = 3
Query: 3243 PRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMR-SEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCL--QDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
PR ++ LG+G FG V AR ++ GE + V +K++ + P C EF ++ ++ +C +V +LLG+ + +P L+I+E GDLK LR L + NP LP G+ + M +IA GM ++ + VH+DLAARN +V+ VKI G+ RD+Y+++Y+ + G+ + P+RWM PE++ ++ SDVWSF V WEI + P NE++L + LE+ C ++ +C +P+ RPSFT I SI++
Sbjct: 975 PREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGV--------LEELEG-CPLQLQELMSRCWQPNPRLRPSFTHILDSIQE 1248
BLAST of Ptk7 vs. TrEMBL
Match: A0A224ACP6 (Receptor protein-tyrosine kinase OS=Dugesia japonica OX=6161 GN=PTK7 PE=2 SV=1) HSP 1 Score: 2029.6 bits (5257), Expect = 0.000e+0 Identity = 995/1202 (82.78%), Postives = 1099/1202 (91.43%), Query Frame = 3
Query: 423 MTMFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFXXXXXXXXXXXXXXXXERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILT----LNNAKVQTMYSSLEQFPSECSHTFLSIIKK 4016
MTMFQR EKDLLLEIVCCIS+LV+GVT DGFY+KK P NKEVEEG VS DCLA PSNNIVY W ND+ IK++N R+LG DNSTL+IDHADR++DPGVY+CIA NSSS+FARKSK GKLEVTWMEPK+EILML+P R+EDLKLTG +LLKC G+ASPKI+K+NINWFFNGNSELP GTR+Q+DGTL IESIS +HFGF+HCLILH GKMDS+ PFIL+LNDK LNP NFS+YEK+G V L CPW GSFVWSKF RLGDPLTLMGSESFPNIEIKG TLTISQ+D+SGD+YYLCQDADKIKARVAVFRV LAKMY+FKR+ FSP LD+N P+VIKKGENGGINFY+DLTSSNSFLFD+IPNP+P IEW+FQDKEIPKYD+NSQ PPRVHV RNRHLVI +AEENDRGTYIIKMHNKAG+R ++F++E+TFPPEF+D ++QP LNEDDSL LDC I ++AS++TTK+YWKKDGTPIA YME LSYENNG+ LKIERAK EHTG YQCF+KS+GYSEF NR QKIIIKAKLQF+GINSDVFLE+NKDGN+HCKTKGYGKI+ KW+K+ +D +NSK T ++ PNEIL+DG+LVLKSVQK+ +GNYLCEAKS TNE+INKTIKLVVGEKPKILK++EN+T+QEG+TLVLDCVA GDP PT+SWFMD+PV GK LITFES KSDNER+K++KNGTLIIKNVAL+DEAKYSCFATNNQ+LSV+ V VKVLTPEEYSKQKLGA FNRGMVKTIIIVVSCAI+YL+LIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDN+QLM+PIVG NPNGGC +K+K SKT+RS PQNSATVNYLPQVPYS P NYY+HYNSSSLPQVGPTYLSNPLIDTNHISEFQ LISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGM M+SMERLTYPRHELQTEG+LGKGEFGDVLLARARNIQDGESQSLVVVKSLM +EPN+CHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDR+NPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLN+KISHLGLCRDIYQSEY+QDGENIFPIRWMPPEAVLQNKYS QSDVWSFAVTCWEIF S LP++KYRNEEILDILT L + KVQTMYS+LEQ P ECSHT LSIIKK
Sbjct: 1 MTMFQRKEKDLLLEIVCCISVLVLGVTSDGFYIKKYPFNKEVEEGSSVSLDCLAVPSNNIVYKWNHNDKIIKFDNHRFLGHDNSTLYIDHADRNIDPGVYFCIALNSSSKFARKSKSGKLEVTWMEPKVEILMLQPARKEDLKLTGIVLLKCHGIASPKITKDNINWFFNGNSELPSGTRIQTDGTLLIESISKNHFGFFHCLILHTTGKMDSLIPFILDLNDKTLNPANFSMYEKEGKTVTLKCPWKNGSFVWSKFLRLGDPLTLMGSESFPNIEIKGSTLTISQMDASGDAYYLCQDADKIKARVAVFRVSLAKMYDFKRDYFSPALDENTPLVIKKGENGGINFYIDLTSSNSFLFDKIPNPIPEIEWSFQDKEIPKYDVNSQTSPPRVHVIRNRHLVILRAEENDRGTYIIKMHNKAGTRFKQFRVEITFPPEFSDRVDSQPQLLNEDDSLKLDCHIIKIASDETTKVYWKKDGTPIAQYMESLSYENNGKILKIERAKSEHTGEYQCFVKSIGYSEFFNRPQKIIIKAKLQFVGINSDVFLEINKDGNIHCKTKGYGKIHTKWFKIFNSDSINSKTTLNSIDSPNEILNDGTLVLKSVQKENSGNYLCEAKSMSTNEIINKTIKLVVGEKPKILKVSENKTVQEGTTLVLDCVAIGDPSPTISWFMDNPVHGKILITFESNKSDNERRKLYKNGTLIIKNVALTDEAKYSCFATNNQLLSVDGNVQVKVLTPEEYSKQKLGAQFNRGMVKTIIIVVSCAISYLILIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNTQLMKPIVGTNPNGGCNSKEKILSKTTRSGPQNSATVNYLPQVPYSSPQNYYMHYNSSSLPQVGPTYLSNPLIDTNHISEFQQLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMGMSSMERLTYPRHELQTEGMLGKGEFGDVLLARARNIQDGESQSLVVVKSLMHNEPNHCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRSNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNIKISHLGLCRDIYQSEYYQDGENIFPIRWMPPEAVLQNKYSPQSDVWSFAVTCWEIFGSTALPMSKYRNEEILDILTSCSSLTHTKVQTMYSNLEQIPPECSHTLLSIIKK 1202
BLAST of Ptk7 vs. TrEMBL
Match: A0A0A7P290 (Ptk7 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 699.893 bits (1805), Expect = 0.000e+0 Identity = 336/336 (100.00%), Postives = 336/336 (100.00%), Query Frame = 3
Query: 1221 MGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKS 2228
MGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKS
Sbjct: 1 MGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKS 336
BLAST of Ptk7 vs. TrEMBL
Match: A0A0R3SAG6 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS1343 PE=4 SV=1) HSP 1 Score: 552.747 bits (1423), Expect = 7.586e-172 Identity = 348/995 (34.97%), Postives = 516/995 (51.86%), Query Frame = 3
Query: 486 LVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETI---KYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLN-------DKNLNPTNFSIYEKQGTNVKLTCPWGVG-------SFVWSKFQRLGDPLTLMGSESFPNIEIKGGT---LTISQLDSSGDSYYLCQ-DADKIKAR-VAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPP----------RVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGY-SEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLI-----------------TFESTKSD----------------NERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGA-HFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRN------------------LTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQN-------------SATVNYLPQVPYSVPPNYYVHYNSSSLPQVG-PTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRS 3173
L+ G + D FY +SP +++VEEG+ + +C P+++I YSW N I K + RRYL D S L I HADRD+DPG Y C A N +S+F S+ + V WM+P IE+++++P R ED++L G + L C ++P NI WF NGN LP R +G L I+ + H G +HC ++H AGK+DS PF+L ++ + ++N +F Y + ++L CP V S VW RLG+ +G S P + + G I + + ++Y C+ +A R VF+VYLA++Y K F+P +N P+ ++ GE + +Y DLT S + + I NP P IEW + +P + + Q+ PP +++V RHLVI+ A E+D G Y + + + AG FQI ++FPPEF + E+Q L+E SL L C I+R A ++IYW+KDG P+ +Y + E +G L+ +H G YQCF+ + GY +F + Q I ++ +LQF+ + FLEVN G + CK +GYG++N+ W++ P P ++ PN++ +G L+ + VQK AG Y+C A+S+ NE I T+K++VGEKP+I I+ NQTIQEGS L+L+C A GDP P +SW + P I F+ ++ +ER +V NG+L+I V L DEA+Y C A N + +GV V VLTP EY+K + G + GM +TI+IVV+CAI YL LI GLTV+CS R ++RR+R LT +N L N ++M N + ++ T V QN S NY+ PP+ + + G P Y + T S +++APPPTPL+SRS+FSG SS NSAS Y+RS
Sbjct: 4 LLTGASTDSFYFTRSPRDQDVEEGQPLRLECTVQPNDDIHYSWLQNGMRIDPDKQSGRRYLEGD-SNLRILHADRDIDPGRYQCQALNKTSKFMSASREASINVYWMDPVIEVMLVQPSRIEDIRLNGVVELACGVKSNPPAKMNNIFWFHNGNGRLP-NMRTLPNGNLIIDHFGMEHVGTFHCRVIHTAGKVDSRPPFVLQVSGEREPQVNSSMNGKSFLKYALKDLPLELACPLPVSSAGDIPLSVVWGYMTRLGEQQQPIG--SLPGVRVTGAADSIFLIDRFEVIHANFYTCEVNAPLTSERYFYVFQVYLAELYTPKPSNFAPRPRQNQPLAVRLGEKLELRYYEDLTPSQLYTAENISNPPPQIEWF---RTLPGH-LEPQRVPPALNSKAESEMKIYVKNGRHLVIKDASESDSGGYEMILSSIAGRVSVPFQIMISFPPEFEPAQESQ--TLDEGQSLILSCHIRRRA-HPGSRIYWEKDGRPLVNYGNDILAEGDGERLRFPHVTVDHQGRYQCFVFTDGYPKKFPGQMQHIEVRGRLQFVREIKEHFLEVNVQGKLTCKVRGYGQLNVNWFR---KTPNGLMP----IQKPNQV-ENGVLIFQYVQKQDAGEYVCVAQSNYQNEEIQMTVKVIVGEKPRISDISTNQTIQEGSRLLLNCKASGDPRPQISWIVKRPNVRDPFIYSTMMSGQPNTDSLLGNVFDPSRPGGEDANLANTLINPAPLDERIQVLSNGSLVINQVLLKDEAEYICIAGNKHAIQTRQGVHVSVLTPHEYAKLENGEDSLSPGMARTIVIVVNCAIAYLGLIFGLTVYCSVRYFKNRRHRAQNAKTPESGHLIAKGGAPLTQDNNCVLLLNDEMM-----TNGSRAPTGSPNDTTATDLGVMQNFNGYRNNGNGKAYSPAANYVMSNEVPAPPSRQLFPPTPQTTANGNPVYPVSVTSTTTGDSCGSRMVAAPPPTPLDSRSHFSGLSSSGNSASAYSRS 974
BLAST of Ptk7 vs. TrEMBL
Match: A0A564Z1M3 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS11765 PE=4 SV=1) HSP 1 Score: 548.895 bits (1413), Expect = 4.139e-170 Identity = 346/988 (35.02%), Postives = 512/988 (51.82%), Query Frame = 3
Query: 507 DGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETI---KYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLN-------DKNLNPTNFSIYEKQGTNVKLTCPWGVG-------SFVWSKFQRLGDPLTLMGSESFPNIEIKGGT---LTISQLDSSGDSYYLCQ-DADKIKAR-VAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPP----------RVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGY-SEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLI-----------------TFESTKSD----------------NERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGA-HFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRN------------------LTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQN-------------SATVNYLPQVPYSVPPNYYVHYNSSSLPQVG-PTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRS 3173
D FY +SP +++VEEG+ + +C P+++I YSW N I K + RRYL D S L I HADRD+DPG Y C A N +S+F S+ + V WM+P IE+++++P R ED++L G + L C ++P NI WF NGN LP R +G L I+ + H G +HC ++H AGK+DS PF+L ++ + ++N +F Y + ++L CP V S VW RLG+ +G S P + + G I + + ++Y C+ +A R VF+VYLA++Y K F+P +N P+ ++ GE + +Y DLT S + + I NP P IEW + +P + + Q+ PP +++V RHLVI+ A E+D G Y + + + AG FQI ++FPPEF + E+Q L+E SL L C I+R A ++IYW+KDG P+ +Y + E +G L+ +H G YQCF+ + GY +F + Q I ++ +LQF+ + FLEVN G + CK +GYG++N+ W++ P P ++ PN++ +G L+ + VQK AG Y+C A+S+ NE I T+K++VGEKP+I I+ NQTIQEGS L+L+C A GDP P +SW + P I F+ ++ +ER +V NG+L+I V L DEA+Y C A N + +GV V VLTP EY+K + G + GM +TI+IVV+CAI YL LI GLTV+CS R ++RR+R LT +N L N ++M N + ++ T V QN S NY+ PP+ + + G P Y + T S +++APPPTPL+SRS+FSG SS NSAS Y+RS
Sbjct: 29 DSFYFTRSPRDQDVEEGQPLRLECTVQPNDDIHYSWLQNGMRIDPDKQSGRRYLEGD-SNLRILHADRDIDPGRYQCQALNKTSKFMSASREASINVYWMDPVIEVMLVQPSRIEDIRLNGVVELACGVKSNPPAKMNNIFWFHNGNGRLP-NMRTLPNGNLIIDHFGMEHVGTFHCRVIHTAGKVDSRPPFVLQVSGEREPQVNSSMNGKSFLKYALKDLPLELACPLPVSSAGDIPLSVVWGYMTRLGEQQQPIG--SLPGVRVTGAADSIFLIDRFEVIHANFYTCEVNAPLTSERYFYVFQVYLAELYTPKPSNFAPRPRQNQPLAVRLGEKLELRYYEDLTPSQLYTAENISNPPPQIEWF---RTLPGH-LEPQRVPPALNSKAESEMKIYVKNGRHLVIKDASESDSGGYEMILSSIAGRVSVPFQIMISFPPEFEPAQESQ--TLDEGQSLILSCHIRRRA-HPGSRIYWEKDGRPLVNYGNDILAEGDGERLRFPHVTVDHQGRYQCFVFTDGYPKKFPGQMQHIEVRGRLQFVREIKEHFLEVNVQGKLTCKVRGYGQLNVNWFR---KTPNGLMP----IQKPNQV-ENGVLIFQYVQKQDAGEYVCVAQSNYQNEEIQMTVKVIVGEKPRISDISTNQTIQEGSRLLLNCKASGDPRPQISWIVKRPNVRDPFIYSTMMSGQPNTDSLLGNVFDPSRPGGEDANLANTLINPAPLDERIQVLSNGSLVINQVLLKDEAEYICIAGNKHAIQTRQGVHVSVLTPHEYAKLENGEDSLSPGMARTIVIVVNCAIAYLGLIFGLTVYCSVRYFKNRRHRAQNAKTPESGHLIAKGGAPLTQDNNCVLLLNDEMM-----TNGSRAPTGSPNDTTATDLGVMQNFNGYRNNGNGKAYSPAANYVMSNEVPAPPSRQLFPPTPQTTANGNPVYPVSVTSTTTGDSCGSRMVAAPPPTPLDSRSHFSGLSSSGNSASAYSRS 992
BLAST of Ptk7 vs. TrEMBL
Match: A0A4S2KY83 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010514 PE=3 SV=1) HSP 1 Score: 554.673 bits (1428), Expect = 5.195e-168 Identity = 330/949 (34.77%), Postives = 489/949 (51.53%), Query Frame = 3
Query: 465 IVCCISLL--VIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETI---KYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKN-------LNPTNFSIYEKQGTNVKLTCPWGVGSF----------VWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDA--DKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPP-------------PRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSE-FHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFM-----------------------------------DSPVQGK-------TLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-RGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVN-PN---------GGCCAKDKSS------SKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVG 3020
++ CI ++G + DGFY +P +++VEEG+ + C PS +I YSW N + + K N RR L D S L I HADRD+DPG Y C A N SS F S+ K+ + WMEP +++ +++P R ED++L + C A+P +S NI W+ NGN+ LP T V+ +G LHI + H G YHC +H AGK+DS PFI+ ND + L +FS + +G +V+L CP +G+ VW RLG+ + S + L I+ D +YY C+ + + V +F+V +A +Y R FSP L K+ P V+K ++ + +Y D + +NSF DQ+ NP P IEW Q + P I PP PR + R RHL++ + E D GTY + + N G F + VTFPPEF + ++ +ED++L+L+C IKR A + +YW+KD + Y HL E NG ++ + +PE G YQCF+++ GYS+ R+Q +++K KLQF+ FLEVN G + CK +GYG + I W++ + P + P + PPN++ G+LV++ V+K AG Y+C A SS N IN T+ +VVGEKP+I +I+ NQT+ G +VL+C A GDP P +SW D +Q + T + + +D R + + NG+L+I L D+A+Y C A N + G+ V+VL+ E+Y++Q+LG + M+KTI+ VV CA+TYL LII LTVFCS RM+R RR R + + K +N QL+ + N PN GGC A S + + S P SA+ LP P P HY+ ++ P +G
Sbjct: 7 LLTCIGFFHFIVGASSDGFYFTVNPNDQDVEEGQPLRLRCAVTPSKDIYYSWLHNGDRVDTEKENGRRTLEVD-SNLQILHADRDLDPGTYQCQALNRSSTFTTASQEAKVNIYWMEPDVQVRLVRPSRYEDIQLGQELEFACHASANPPLSPFNIKWYHNGNARLP-NTEVRQNGNLHIAVLGAEHIGSYHCRAVHAAGKLDSRPPFIIQFNDASPPQLVTTLVHQDFSKFVMRGRSVELICP-KIGAHMPVDGIPPITVWGYMPRLGEQQQSITSIRDTKLVDMDSKLVITNFDIHHVNYYTCEISSYNSPDKYVFLFQVEMATLYTPTRADFSPRLKKSQPYVVKINDDAELRYYSDQSPANSFFADQMSNPAPRIEWHKQGEHQP---IVPWAPPVLTHSPVTHSPQRPRRYALRGRHLIVHQVAEADSGTYEMTLSNVVGRVSITFDLLVTFPPEFYQALTHEEHSFDEDETLNLNCGIKRRALPGSV-VYWEKDQRVLRKYDSHLVLEENGEQIRFTKLRPEDQGQYQCFVQTDGYSKRAAGREQTLVVKGKLQFLREIRKHFLEVNTQGRIPCKVRGYGTLKIDWFRKVGNRPSDFLP----IHPPNQVEPGGTLVIQYVRKSDAGQYVCLAHSSYKNAQINMTVNVVVGEKPQISQISSNQTVSVGKQVVLNCHATGDPLPQISWIAKRIGFTLYTPKFDPNENGTPEAKSSNAEQQHTTKPDGSMQDEANSDPVMTALLSRNAPTDQSRVRAYPNGSLVINQANLLDQAEYICVANNTHAVEARLGLFVRVLSAEDYTRQQLGEEGSGSSMLKTILTVVGCAVTYLGLIIALTVFCSMRMVRTRRKR---SHKVSKAHENGQLLTQLGEPNCPNGATGNSQDSGGCHANTLDSGFFLQGTGSGASAP-GSASFGPLPGQPQIFHP----HYHRATDPLLG 936 HSP 2 Score: 249.98 bits (637), Expect = 2.554e-63 Identity = 165/390 (42.31%), Postives = 232/390 (59.49%), Query Frame = 3
Query: 3078 LISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFXXXXXXXXX---------------------XXXXXXXERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ--DGENIFPIRWMPPEAVLQN------------------------KYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEIL-----DILTL--NNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
L+SAPPPTPL+SRS+FSG +SS NS S+Y+RS S ++N G ++ +R+ YPR EL+ EGILGKG FGDV LARAR+IQ+ E QSLV+VKSL+ E ++ +EFHRQL++ + D V +LLG+C+E EP ++LEYCEWGDLK FLR ++ D L +T QK+ MC +A GME+ S +RCVH+DLAARNIL+T ++++KIS LGL RD+Y SEY+ +G+ P+RW+ PE +++ Y+IQSDVW+FAV EIFS LPL++ ++EI+ LT N AK P+E H +++ +C S + RP FT++ ++D
Sbjct: 1063 LMSAPPPTPLDSRSHFSG-ISSGNSTSLYSRSLLSGASNVGPSPRGDGAQTVNDNYSSYGVVNGASTISQADRMHYPRCELKVEGILGKGVFGDVFLARARHIQEEEMQSLVLVKSLISHESSHINEFHRQLEMFGKLNHDCVARLLGVCMEQEPFYMLLEYCEWGDLKMFLRRIRESDAQTCKLLSVTYAQKLKMCHTLACGMEHFSQLRCVHRDLAARNILLTQEMDLKISSLGLARDVYASEYYHIPNGDQFIPLRWLAPELIVEALPLSRPGVNANQLDYGHSFAGPSLPYTIQSDVWAFAVVVCEIFSLATLPLSRLTDQEIIVAGRHTALTAHENIAKDPNHIPLRPDIPAEIPHELSNLLLRCWSPVARQRPEFTEVVSVLRD 1451
BLAST of Ptk7 vs. Ensembl Cavefish
Match: PTK7 (inactive tyrosine-protein kinase 7-like [Source:NCBI gene;Acc:103037717]) HSP 1 Score: 204.142 bits (518), Expect = 3.972e-53 Identity = 112/285 (39.30%), Postives = 179/285 (62.81%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPY-LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
++L +PR ++Q LGKGEFG+V LA+AR I++GE +++V+VKSL + EF RQ ++ ++ + +LLG+C + +P +ILEY + GDLKQFLR + + P ++ K+++CAQ+A GME++S R VHKDLAARN L++ Q VK+S LGL +D+Y SEY+ + + P+RW+P E+V + +S +SDVW+F V WE+FS LP + +EE+L+ L K+ P CS ++ +C + P+ RPSF+++ +++ D
Sbjct: 679 DKLHFPRADMQNITTLGKGEFGEVFLAKARGIEEGEEETVVLVKSLQSRDELSQTEFKRQAEMFSKLSHPNIVRLLGLCRDTDPHYIILEYVDLGDLKQFLRISKGKDEKLKPQPISTKTKISICAQVAAGMEHLSNQRFVHKDLAARNCLISGQRQVKVSALGLSKDVYNSEYYHYRQKLVPLRWLPAESVADDDFSTKSDVWAFGVLMWEVFSHGELPYSTLSHEEVLEGLQAGTLKLSA--------PDACSSKIYKLMSRCWAPSPKERPSFSELVLALGD 955 HSP 2 Score: 119.013 bits (297), Expect = 1.612e-26 Identity = 127/533 (23.83%), Postives = 212/533 (39.77%), Query Frame = 3
Query: 1260 GTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFA----DSA--ENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVV-------KVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
GTL I+Q+ + Y C + ++ A ++ + +M + FS NL + + +G +P P + W + +P RV+ +L+ E D GTYI NKAG R ++ + VT PPE+A D+A E QP YL+ C ++ S K+ W ++ I NG L+I + +Y+C +++G Q ++ + KL+F L+++ + ++ C G I+W + + VE N G+L + V + AGNY C A +S+ E I I L VG + E T+ +G T +L C A GDP P + W + V + F+ NG+L+I +V D KY+C A N I S+ + V K + P++ K M++TI + V A+ Y++ ++G +C R R+ + E
Sbjct: 178 GTLRITQVKNRSTGRYRCVAHYGEDKQVDAGASLHIAEIGEMGGRMSKFFSTNLLEKITCEAPQG-----------------------HPEPEVWWERAGQRVPSEG--------RVY-HEGLNLIFSPTEGGDSGTYICVAQNKAGMRRQEVNVIVTGPPEWATRPHDTAMEEGQPGYLH--------CHVQ---STPPAKVTWFRNVQEINEEDTRFKVFPNG-TLRINSVEVYDGVIYRCHCRAVGGQ--LTAQARVTVLEKLKFTPTPQPSQCLQLDSEASVQCSAIGRETPTIRWTR------ADGSAVGSHVEQVN-----GALHFQKVMRSDAGNYTCVASNSLQGE-IRAYISLTVGVYIEFKLEPEYTTVYQGHTAMLHCQATGDPQPFIQWMVKDKVLSLSSGRFQK----------MPNGSLVITDVTTDDTGKYTCVAGN--ICSIRDRVAQLYVVEKPKHVIPDDDGKTPY------KMIQTIGLSVGAAVAYIIAVLGFMFYCKQRRNAKRQQKGQDGE 634 HSP 3 Score: 51.6026 bits (122), Expect = 7.977e-6 Identity = 80/387 (20.67%), Postives = 149/387 (38.50%), Query Frame = 3
Query: 1515 PVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMH---NKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITE-NQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNN------QILSVEEGVVVKVLTPEEYS 2645
P P+I+W +D+ + IN RV V+ N L I + + G Y H +K I E + + + + + C+ + E +++W++ G + S E Y + G NL + +G Y C ++ + ++ +I+ ++ D +E + G +HC + + W++ + +N + T V P +G+L + SV+ Y C ++ + ++ V EK K + +Q +Q S + C A G PT+ W T + S E+ NG L + V SD Y+C A+N+ +S+ GV ++ EY+
Sbjct: 153 PPPVIQWLHEDEPV----INKT----RVIVYNNGTLRITQVKNRSTGRYRCVAHYGEDKQVDAGASLHI-----AEIGEMGGRMSKFFSTNLLEKITCEAPQGHPE--PEVWWERAGQRVPS--EGRVY-HEGLNLIFSPTEGGDSGTYICVAQN--KAGMRRQEVNVIVTGPPEWATRPHDTAMEEGQPGYLHCHVQSTPPAKVTWFRNV--QEINEEDTRFKVFP------NGTLRINSVEVYDGVIYRCHCRA--VGGQLTAQARVTVLEKLKFTPTPQPSQCLQLDSEASVQCSAIGRETPTIRW---------TRADGSAVGSHVEQ----VNGALHFQKVMRSDAGNYTCVASNSLQGEIRAYISLTVGVYIEFKLEPEYT 496
BLAST of Ptk7 vs. Ensembl Cavefish
Match: PTK7 (inactive tyrosine-protein kinase 7-like [Source:NCBI gene;Acc:103037717]) HSP 1 Score: 204.527 bits (519), Expect = 5.682e-53 Identity = 112/285 (39.30%), Postives = 179/285 (62.81%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPY-LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
++L +PR ++Q LGKGEFG+V LA+AR I++GE +++V+VKSL + EF RQ ++ ++ + +LLG+C + +P +ILEY + GDLKQFLR + + P ++ K+++CAQ+A GME++S R VHKDLAARN L++ Q VK+S LGL +D+Y SEY+ + + P+RW+P E+V + +S +SDVW+F V WE+FS LP + +EE+L+ L K+ P CS ++ +C + P+ RPSF+++ +++ D
Sbjct: 778 DKLHFPRADMQNITTLGKGEFGEVFLAKARGIEEGEEETVVLVKSLQSRDELSQTEFKRQAEMFSKLSHPNIVRLLGLCRDTDPHYIILEYVDLGDLKQFLRISKGKDEKLKPQPISTKTKISICAQVAAGMEHLSNQRFVHKDLAARNCLISGQRQVKVSALGLSKDVYNSEYYHYRQKLVPLRWLPAESVADDDFSTKSDVWAFGVLMWEVFSHGELPYSTLSHEEVLEGLQAGTLKLSA--------PDACSSKIYKLMSRCWAPSPKERPSFSELVLALGD 1054 HSP 2 Score: 163.31 bits (412), Expect = 4.132e-40 Identity = 184/796 (23.12%), Postives = 315/796 (39.57%), Query Frame = 3
Query: 489 VIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIE------IKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFA----DSA--ENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVV-------KVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
V+ V + K P +++ G+ C + + + YSW + +T+ + RR+L + S L DR +D G + C+A N +S S + W+E + + +P +++ +I+L+CQ P+ N W+ +G + + TL +++ G Y C + A ++ S T L++ DK + P E Q V L V +F P+ E P I GTL I+Q+ + Y C + ++ A ++ + +M + FS NL + + +G +P P + W + +P RV+ +L+ E D GTYI NKAG R ++ + VT PPE+A D+A E QP YL+ C ++ S K+ W ++ I NG L+I + +Y+C +++G Q ++ + KL+F L+++ + ++ C G I+W + + VE N G+L + V + AGNY C A +S+ E I I L VG + E T+ +G T +L C A GDP P + W + V + F+ NG+L+I +V D KY+C A N I S+ + V K + P++ K M++TI + V A+ Y++ ++G +C R R+ + E
Sbjct: 33 VLCVQASSLHFSKEPKSQDASHGRSAMLRCEVSEAAGVSYSWLQDGQTVLDSERRFL--EGSNLKFTAVDRHLDTGNFQCVATNVASGEVATSANASFNIKWLESG-PVTLKEPASIQEIDGAEQIVLQCQIDGHPR---PNSKWYKDGTA------LSGKEKTLTLKNPVPGDSGTYSCCARNGALQICSNTNLTLSIIDKTI-PRLVVAPEDQ---VVLRNEEAV---FHCQFSAKPPPVIQWLHEDEPVINKTRVIVYNNGTLRITQVKNRSTGRYRCVAHYGEDKQVDAGASLHIAEIGEMGGRMSKFFSTNLLEKITCEAPQG-----------------------HPEPEVWWERAGQRVPSEG--------RVY-HEGLNLIFSPTEGGDSGTYICVAQNKAGMRRQEVNVIVTGPPEWATRPHDTAMEEGQPGYLH--------CHVQ---STPPAKVTWFRNVQEINEEDTRFKVFPNG-TLRINSVEVYDGVIYRCHCRAVGGQ--LTAQARVTVLEKLKFTPTPQPSQCLQLDSEASVQCSAIGRETPTIRWTR------ADGSAVGSHVEQVN-----GALHFQKVMRSDAGNYTCVASNSLQGE-IRAYISLTVGVYIEFKLEPEYTTVYQGHTAMLHCQATGDPQPFIQWMVKDKVLSLSSGRFQK----------MPNGSLVITDVTTDDTGKYTCVAGN--ICSIRDRVAQLYVVEKPKHVIPDDDGKTPY------KMIQTIGLSVGAAVAYIIAVLGFMFYCKQRRNAKRQQKGQDGE 733
BLAST of Ptk7 vs. Ensembl Cavefish
Match: PTK7 (inactive tyrosine-protein kinase 7-like [Source:NCBI gene;Acc:103037717]) HSP 1 Score: 204.142 bits (518), Expect = 5.801e-53 Identity = 112/285 (39.30%), Postives = 179/285 (62.81%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPY-LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
++L +PR ++Q LGKGEFG+V LA+AR I++GE +++V+VKSL + EF RQ ++ ++ + +LLG+C + +P +ILEY + GDLKQFLR + + P ++ K+++CAQ+A GME++S R VHKDLAARN L++ Q VK+S LGL +D+Y SEY+ + + P+RW+P E+V + +S +SDVW+F V WE+FS LP + +EE+L+ L K+ P CS ++ +C + P+ RPSF+++ +++ D
Sbjct: 748 DKLHFPRADMQNITTLGKGEFGEVFLAKARGIEEGEEETVVLVKSLQSRDELSQTEFKRQAEMFSKLSHPNIVRLLGLCRDTDPHYIILEYVDLGDLKQFLRISKGKDEKLKPQPISTKTKISICAQVAAGMEHLSNQRFVHKDLAARNCLISGQRQVKVSALGLSKDVYNSEYYHYRQKLVPLRWLPAESVADDDFSTKSDVWAFGVLMWEVFSHGELPYSTLSHEEVLEGLQAGTLKLSA--------PDACSSKIYKLMSRCWAPSPKERPSFSELVLALGD 1024 HSP 2 Score: 164.466 bits (415), Expect = 1.449e-40 Identity = 185/797 (23.21%), Postives = 318/797 (39.90%), Query Frame = 3
Query: 486 LVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIE------IKGGTLTISQLDSSGDSYYLC----QDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFA----DSA--ENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVV-------KVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAE 2804
L++ V + K P +++ G+ C + + + YSW + +T+ + RR+L + S L DR +D G + C+A N +S S + W+E + + +P +++ +I+L+CQ P+ N W+ +G + + TL +++ G Y C + A ++ S T L++ DK + P E Q V L V +F P+ E P I GTL I+Q+ + Y C + ++ A ++ + +M + FS NL + + +G +P P + W + +P RV+ +L+ E D GTYI NKAG R ++ + VT PPE+A D+A E QP YL+ C ++ S K+ W ++ I NG L+I + +Y+C +++G Q ++ + KL+F L+++ + ++ C G I+W + + VE N G+L + V + AGNY C A +S+ E I I L VG + E T+ +G T +L C A GDP P + W + V ++ S +S NG+L+I +V D KY+C A N I S+ + V K + P++ K M++TI + V A+ Y++ ++G +C R R+ + E
Sbjct: 4 LMLCVQASSLHFSKEPKSQDASHGRSAMLRCEVSEAAGVSYSWLQDGQTVLDSERRFL--EGSNLKFTAVDRHLDTGNFQCVATNVASGEVATSANASFNIKWLESG-PVTLKEPASIQEIDGAEQIVLQCQIDGHPR---PNSKWYKDGTA------LSGKEKTLTLKNPVPGDSGTYSCCARNGALQICSNTNLTLSIIDKTI-PRLVVAPEDQ---VVLRNEEAV---FHCQFSAKPPPVIQWLHEDEPVINKTRVIVYNNGTLRITQVKNRSTGRYRCVAHYGEDKQVDAGASLHIAEIGEMGGRMSKFFSTNLLEKITCEAPQG-----------------------HPEPEVWWERAGQRVPSEG--------RVY-HEGLNLIFSPTEGGDSGTYICVAQNKAGMRRQEVNVIVTGPPEWATRPHDTAMEEGQPGYLH--------CHVQ---STPPAKVTWFRNVQEINEEDTRFKVFPNG-TLRINSVEVYDGVIYRCHCRAVGGQ--LTAQARVTVLEKLKFTPTPQPSQCLQLDSEASVQCSAIGRETPTIRWTR------ADGSAVGSHVEQVN-----GALHFQKVMRSDAGNYTCVASNSLQGE-IRAYISLTVGVYIEFKLEPEYTTVYQGHTAMLHCQATGDPQPFIQWMVKDKV-----LSLSSGRS-------MPNGSLVITDVTTDDTGKYTCVAGN--ICSIRDRVAQLYVVEKPKHVIPDDDGKTPY------KMIQTIGLSVGAAVAYIIAVLGFMFYCKQRRNAKRQQKGQDGE 703
BLAST of Ptk7 vs. Ensembl Cavefish
Match: ntrk2a (neurotrophic receptor tyrosine kinase 2 [Source:NCBI gene;Acc:103036414]) HSP 1 Score: 150.214 bits (378), Expect = 1.871e-36 Identity = 92/280 (32.86%), Postives = 147/280 (52.50%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
RH + + LG+G FG V LA N+ + + LV VK+L + N +FHR+ +LL + +++ G+C+E +P +++ EY + GDL +FLR + D LT+ Q + + QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ +SDVWS V WEIF+ P + N E+++ +T + Q P C ++ C +P R + +I
Sbjct: 507 RHNIVLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASENARKDFHREAELLTNLQHEHIVTFYGMCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQVQQQAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---------QGRVLQRPRTCPKEVYDLMLGCWQREPHTRLNIKEI 777
BLAST of Ptk7 vs. Ensembl Cavefish
Match: ntrk1 (neurotrophic tyrosine kinase, receptor, type 1 [Source:ZFIN;Acc:ZDB-GENE-980526-118]) HSP 1 Score: 147.132 bits (370), Expect = 5.102e-36 Identity = 95/281 (33.81%), Postives = 149/281 (53.02%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGME-NISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
R ++ + LG+G FG V LA N+ + LV +K+L + + +F R+ +LL + +++ + G+C + EP ++ EY GDL +FLR L + P + LT Q + + AQIA GM N++ + VH+DLA RN LV L VKI G+ RDIY ++Y++ G + PIRWMPPE+++ K++ +SD+WSF V WEIF+ P + N E ++ +T LE+ P C +++ C +PQ R DI
Sbjct: 331 RQDIMLKWELGEGAFGKVYLAECANLCPDTDKMLVAIKTLKDANESTRQDFQREAELLTVLQHEHIVRFYGVCTDGEPLAMVFEYMRHGDLNRFLRAHGPDARILDEVKMPPMGQLTLPQMLQIAAQIASGMVLNLASLHFVHRDLATRNCLVGEGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIMYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNSEAIECITQGR--------ELER-PRTCPKEVHLLMQGCWQREPQQRLVIKDI 602
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006545.1 (pep scaffold:Pmarinus_7.0:GL476470:1226125:1235807:-1 gene:ENSPMAG00000005912.1 transcript:ENSPMAT00000006545.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 166.007 bits (419), Expect = 2.109e-45 Identity = 101/283 (35.69%), Postives = 163/283 (57.60%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNI---QDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ-DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQS-EYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
+R T + +Q +LGKG+FG+V LA+ + GE++++ +VK+L + EF R++DL + +V + + EP ++LEY + GDLKQ+L+ + D + LT QK+++C Q+A+GM ++S R VH DLAARN LV+ +VKIS GL RD+Y S EYF+ + + P+RWM PEAV + S +SDVW+ V WE+ + LP AK ++EE+ + + K + + L ++++CL+ P++RPSF D+
Sbjct: 34 DRPTVAKQSIQRITLLGKGQFGEVYLAKVAGLTLPAAGEAETVAMVKALGSRDERAQAEFQREVDLFGKAS--HVAVARLLAVCKEPLQMVLEYTDLGDLKQYLKLSRGDDKEIKMKPLTAQQKLSVCVQVAQGMVHLSSQRLVHGDLAARNCLVSSDNSVKISCPGLSRDVYISPEYFEHRQALIPLRWMAPEAVAEGDLSTKSDVWAVGVLLWEVCTLGELPYAKLKDEEVFRAVQSGSLKPLSTKACLAHVS--------KLLQRCLAPSPRDRPSFPDV 306
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 148.673 bits (374), Expect = 6.228e-38 Identity = 91/271 (33.58%), Postives = 142/271 (52.40%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSL-----MRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ--DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
LG+G FG V AR I GE ++ V +K++ MR +EF + ++ C +V +LLG+ + +P L+I+E GDLK +LR L+ P P + + + M +IA GM ++ + VH+DLAARN +V VKI G+ RDIY+++Y+ + G+ + P+RWM PE++ ++ SDVWSF V WEI + P NE++L + M L P C +I+KC +P+ RP+F +I
Sbjct: 67 LGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRER----YEFLNEASVMKSFNCHHVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFV---------MDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 324
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 143.665 bits (361), Expect = 6.530e-38 Identity = 93/280 (33.21%), Postives = 144/280 (51.43%), Query Frame = 3
Query: 3273 LGKGEFGDVLLARARNIQDGESQSLVVVKSL-----MRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCL----QDRTN-------PNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
LG+G FG V AR I GE ++ V +K++ MR +EF + ++ C +V +LLG+ + +P L+I+E GDLK +LR L +D T P P + + + M +IA GM ++ + VH+DLAARN +V VKI G+ RDIY+++Y+ + G+ + P+RWM PE++ ++ SDVWSF V WEI + P NE++L + M L P C +I+KC +P+ RP+F +I
Sbjct: 19 LGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRER----YEFLNEASVMKSFNCHHVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEDFTETIVLEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFV---------MDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 285
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 143.28 bits (360), Expect = 3.955e-37 Identity = 94/287 (32.75%), Postives = 148/287 (51.57%), Query Frame = 3
Query: 3240 YPRHELQTEGI-----LGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC-------LQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
Y H ++ + I LG+G FG V LA ++ G+ LV K+L +F+R+ +LL + +++ + G+C+E EP +++ EY + GDL +FLR + D L++ Q + M +QIA GM ++ VH+DLA RN LV L VKI G+ RD+Y ++Y++ G + PIRWMPPE+++ K++ SDVWS V WEIF+ P + N E++D + LE+ P C ++ C +PQ+R DI
Sbjct: 66 YTAHHIKRQDIALMCELGEGAFGKVYLAECSSLDVGQEPMLVAAKTLKDLSDGARKDFYREAELLTNLQHEHIVRFYGVCVEGEPLIMVFEYMKNGDLNKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRV--------LER-PRSCPMEVYELMLGCWHREPQHRLGIKDI 343
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 119.013 bits (297), Expect = 6.433e-30 Identity = 60/165 (36.36%), Postives = 92/165 (55.76%), Query Frame = 3
Query: 3570 LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGEN-IFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
L K+ + Q+A GM ++ + VH+DLA RN LV +L VKIS GL + IY ++Y++ EN PIRWMPPE++ N+Y+ +SDVW+F V WEIFS + P +EE++ + N + P C ++++ C + P +RPSF +
Sbjct: 81 LCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKANENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGN---------VLACPDGCPLDLYNLMRLCWAHAPADRPSFASV 236
BLAST of Ptk7 vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061]) HSP 1 Score: 66.6254 bits (161), Expect = 1.682e-11 Identity = 70/287 (24.39%), Postives = 129/287 (44.95%), Query Frame = 3
Query: 3231 RLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSL--MRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMT--MCAQIAKG-MENISYI---RCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYR---NEEILDILTLNNAKVQTMYSSLEQFPS---ECSHTFLSIIKKCLSIDPQNRPS 4049
R + + E+ T GILG+G G V R +N + + +K++ M ++P Y + R+L + DY+ + G+ + + + + G + L+ T NL L +G +++ + +IA+ + +SY+ + +H+D+ +NIL+ + +K+ G+ + S F +M PE + YS+ DVWS +T E+ + P + N +++LT+ + T L+ P S TF S I CL D + RPS
Sbjct: 206 RFGHLKDEITTLGILGEGAGGSVAKCRLKN-----GKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGG-----KSLE-ATYKNL--LKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSF---YMAPERIQGQPYSVTCDVWSLGLTLLEV-AGGRFPFESDKITQNVAPIELLTM----ILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPS 471
BLAST of Ptk7 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 63.929 bits (154), Expect = 1.856e-10 Identity = 42/164 (25.61%), Postives = 77/164 (46.95%), Query Frame = 3
Query: 3570 LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
LT+GQ +C + G+E + +H+D+ + NIL++ + ++K++ G C I + + P WM PE V + +Y + D+WS + E+ Y NE L L L + T + + P S + + CL ++P++R S T++
Sbjct: 711 LTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPY-WMAPEVVSRKEYGPKVDIWSLGIMIIEMIEG----EPPYLNETPLRALYL----IATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATEL 865
BLAST of Ptk7 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757]) HSP 1 Score: 57.3806 bits (137), Expect = 1.112e-8 Identity = 69/282 (24.47%), Postives = 123/282 (43.62%), Query Frame = 3
Query: 3246 RHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMT--MCAQIAKG-MENISYI---RCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSS--------IVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPS 4049
+ ++T GILG+G G V + +N G + V + + ++P Y + R+L + +Y+ + G+ + E + + G R L D NL L +G +++ + +IA+ + +SY+ + +H+D+ +NIL+ VK+ G+ + S F +M PE + YS+ SDVWS +T E+ + + +A + E ++ ILT S++ PS F S I CL D + RPS
Sbjct: 218 KDRIETLGILGEGAGGSVSKCKLKN---GSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGG-----RSL-DAIYKNL--LERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSF---YMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPF--ELLMWILTFTPELKDEPESNIIWSPS-----FKSFIDYCLKKDSRERPS 478
BLAST of Ptk7 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 55.0694 bits (131), Expect = 9.456e-8 Identity = 59/266 (22.18%), Postives = 121/266 (45.49%), Query Frame = 3
Query: 3270 ILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLAR-TECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNK-YSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++G+G+FG ++ + N++ G ++ V+ + S+ + + R++ LA + +T+ G ++ +I+E+C G L+ LR + + + + ++ ++ I +H+D+ A N+L+T + NVK+ G+ + Q+ + P WM PE +++ Y + D+WS +T +EI + Y + E L + L +++ LE S + I CL DP+ R S D+
Sbjct: 28 VIGRGKFG--VVYKGYNVKTGRVYAIKVLN--LDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK---------IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPY-WMAPEVIMEGVYYDTKVDIWSLGITTYEIATGN----PPYCDVEALRAMQL---IIKSKPPRLED--RSYSTSLKEFIALCLDEDPKERLSADDL 270
BLAST of Ptk7 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 53.5286 bits (127), Expect = 2.018e-7 Identity = 40/162 (24.69%), Postives = 70/162 (43.21%), Query Frame = 3
Query: 3570 LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTL--NNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPS 4049
L + Q + + +G++ + + +H+D+ + NIL+ Q VKI+ G C ++ + + + WM PE V Q Y + DVWS + E+ Y NE+ L L L NN + + P S + CL ++ ++R S
Sbjct: 479 LNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRS-KRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEG----EPPYLNEDPLKALYLIANNGSPKLRH------PESVSKQTKQFLDACLQVNVESRAS 629
BLAST of Ptk7 vs. Ensembl Nematostella
Match: EDO41236 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7S4Y9]) HSP 1 Score: 179.489 bits (454), Expect = 2.571e-50 Identity = 107/286 (37.41%), Postives = 161/286 (56.29%), Query Frame = 3
Query: 3234 LTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIE 4091
+ +PRH+L+ LG G +G LARA I+DGE +++VVVKSL+ + +F R+L+ L E V LLG+C + EP +I E E GDLKQFL D L T K+TMC+ I GM ++ + VHKDLAARN +VT L VKI L L D+Y +EY++ + P+RWMP EA+ + ++ +SDVWSF V WEI+S +P +EE+L + ++ ++ P C +++KKC +P +RP+F I + + +++
Sbjct: 1 MEFPRHDLEALRTLGNGSYGRAFLARASGIKDGERETMVVVKSLIAKDDIVREDFTRELESLVNMEHSNVVSLLGVCRDSEPFYMIFECFEKGDLKQFLLSCNDNGRSTL---TSSHKLTMCSNIVSGMSYLAANKFVHKDLAARNCMVTKDLQVKIGFLNLSYDLYNAEYYRFNNILIPLRWMPSEAIFHDDFTEKSDVWSFGVLAWEIYSLGQIPYTDRSDEEVLKCVK-DDLRLPK--------PDNCPDNMANVMKKCWEPNPNDRPNFDMIFAEMSEVAVD 274
BLAST of Ptk7 vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 132.494 bits (332), Expect = 7.336e-34 Identity = 86/277 (31.05%), Postives = 142/277 (51.26%), Query Frame = 3
Query: 3243 PRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCH-EFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRT--NPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYF-QDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
PR +++ LG G FG V A +I + + V VK++ + EF ++ ++ +C++V +LLG+ + +P L+++E + GDLK FLR + + P T Q + M +IA GM ++ + VH+DLAARN +V L VKI G+ RDIY+++Y+ + G+ + P+RWM PE++ ++ SDVWSF V WE+ + P NEE+L + + P +C ++ C P+ RP+F I
Sbjct: 14 PREKIKLIRELGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPTLVVMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPK---------PDDCPDRLFDLMTLCWQFSPKARPTFLSI 281
BLAST of Ptk7 vs. Ensembl Nematostella
Match: EDO49315 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHA0]) HSP 1 Score: 129.798 bits (325), Expect = 1.494e-32 Identity = 98/299 (32.78%), Postives = 147/299 (49.16%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDY-------VTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRC---LQDRTNPNLPY--LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ---DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
E + R L +LG+G FG V+ A A + + + V VK L DL++ E + LLG C + P +++EY WG+L+QFLR ++D + P LT MT C QIAKGME ++ +C+H+DLAARNILV +KI+ GL RD++ +Y++ DG P++WM EA+ Y+ QSDVWSF + WEI + P E++ +L T Y + P CS I++ C + +P+ RP+FT + + D
Sbjct: 50 EEWEFDRTYLVIREVLGEGAFGKVMRAEAFGLHGNSACTTVAVKMLKEDATE-----QELFDLVSEMEVMKSIGKHINIINLLGTCTQHGPLFVLVEYARWGNLRQFLRDRRPVKDYDDVMEPAETLTLLNLMTFCYQIAKGMEYLASRKCIHRDLAARNILVADDNILKIADFGLARDVHNVDYYRKTTDGR--LPVKWMAFEALFDRVYTTQSDVWSFGIVVWEIITFGGTPYPGVPIEKLCMLL-------NTGYRM--ERPVNCSKELYEIMRNCWNENPEARPTFTSLVQAFDD 332
BLAST of Ptk7 vs. Ensembl Nematostella
Match: EDO37886 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEI8]) HSP 1 Score: 126.716 bits (317), Expect = 7.293e-32 Identity = 93/297 (31.31%), Postives = 149/297 (50.17%), Query Frame = 3
Query: 3240 YPRHELQTEGILGKGEFGDVLLARARNI-----QDGESQSLVVVKSLMR---SEPNYCHEFHRQLDLLAR-TECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPY--------LTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSE-YFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIK 4076
+P L + +LG G FG V+ A A I +D S++ V +++ SE +Y + +L ++ E + LLG C E +LILEY + G+L QFLR +D P T ++ QIA+GM+ ++ +C+H+DLAARN+LV +KI GL RDIY+++ Y + G + P++WM PEA+ +YS ++DVW+F V WEI + P E++LD + Q P +C +I+ C S++ RP+F ++ I+
Sbjct: 10 FPEKRLILQEVLGSGAFGQVIKAEAIGILSLSARDKTSEATTVAVKMLKENASESDY-KDLASELKIMIHLGEHKNIINLLGACTRGENLMLILEYAKHGNLLQFLRTRRDIYEPTWKKTTFNPKTEFTLADQVVDAYQIAQGMDFLASKKCIHRDLAARNVLVDEGYALKIGDFGLARDIYKTDLYVKKGAGLLPVKWMAPEALFDREYSSKTDVWAFGVVLWEILTLGGSPYPGVPLEQLLDYINEGKRMAQ---------PRDCPPEIYAIMCDCWSLEQDRRPTFAELVRRIE 296
BLAST of Ptk7 vs. Ensembl Nematostella
Match: EDO45490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSX1]) HSP 1 Score: 122.865 bits (307), Expect = 2.184e-31 Identity = 60/175 (34.29%), Postives = 100/175 (57.14%), Query Frame = 3
Query: 3510 GDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQ-DGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSID 4031
GDL Q++R + LT+ +++ Q++ GME++ +R VH+DLA RN LV L VKI+ G+ RD+Y S+Y++ +G+ + PIRWMPPEA+L +++++SDV+SF V WE+++ + P Y NEE+ + + P +C ++K C + D
Sbjct: 59 GDLNQYMRKRGPYSLEEEKSLTQEDLLSISLQVSSGMEHLQSMRFVHRDLATRNCLVGDGLVVKIADFGMSRDVYASDYYKVEGQAVMPIRWMPPEALLYGRFTVESDVYSFGVLLWEVYAFALQPYYGYTNEEVCGFIKKGVHLGK---------PEDCPDHIYDVMKSCWNKD 224
BLAST of Ptk7 vs. Ensembl Medaka
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:NCBI gene;Acc:101172356]) HSP 1 Score: 205.297 bits (521), Expect = 2.055e-53 Identity = 116/280 (41.43%), Postives = 179/280 (63.93%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNP--NLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++L +PR LQT LGKGEFG+VLLA+A++I++GE +++V+VKSL + +F R+ ++ ++ V +LLG+C E EP ++LEY + GDLKQ+LR + + + + P TK KM++CAQ+A+GME++S R VHKDLAARN L+ Q VK+S L L +D+Y SEY+ ++ P+RW+P E+V ++ S +SDVW+F V WE+FS +P +K +EE+L+ L K+ P C ++ +C ++ P+ RPSFTDI
Sbjct: 690 DKLHFPRANLQTITTLGKGEFGEVLLAKAKSIEEGEEETVVLVKSLQTRDEQLQQDFRREAEMFSKLSHANVVRLLGLCREAEPHYMVLEYYDRGDLKQYLRISKSKDDKVKSQPLSTK-TKMSLCAQVARGMEHLSNHRFVHKDLAARNCLINSQRRVKVSSLSLSKDVYNSEYYHYRQSWIPLRWLPSESVFEDDLSTKSDVWAFGVLMWEVFSHGEMPYSKLDDEEVLEGLKAGKLKLPP--------PEGCPSKIYKLMARCWALGPKERPSFTDI 960 HSP 2 Score: 120.939 bits (302), Expect = 4.005e-27 Identity = 148/669 (22.12%), Postives = 259/669 (38.71%), Query Frame = 3
Query: 813 ILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQ----GTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAV-FRVYLAKMYEFKREQ---FSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNR-HLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-------RGMVKTIIIVVSCAITYLVLIIGLTVFCSFR 2765
+ + +P ED++ + + L+C P+ + +W+ +G ++ + + TL I+S S G Y C + AG + S F LN+ D++ P E Q C + ++ DPL S + G+L I+Q+ Y C + VA+ + +A++ + + E+ F N + V +G+ P P + W + Q+ P VF+ LV E D G Y NKAG R ++ + V PE+ ++ L E L C + + T W ++ + NG L+I + +Y C ++ G S + ++ + KL+F LE++K+ + C G I+W K + L P+ DG L V + AGNY C A +S+ E I + L+V + EN T+ +G T VL C A GDP P + W + + ++ + N+R + NG+L+I +V D +Y+C A N+ +K L + Y +K ++ M++TI + V A+ Y+++++GL +C R
Sbjct: 40 LTLKEPLSEEDIQSSAPVTLRCHIDGHPRPT---CHWYKDGVKLTEKTHQINNKERTLTIKSASPDDSGLYSCCAKNAAGSVCSNPNFTLNIIDESF-PRPVVTPEDQVVMKNEEAVFHCQFTAEPPPTLEWFHENDPL----SNKSRIFLLSNGSLLITQVKPRNTGTYRCVGRGLRGSHVALEASLLIAEIEDMEPEKSLVFQANTQQRVACRPPRGK-----------------------PSPDVWW----------ERGGQRVPAEGRVFQEGLDLVFNPTAEGDSGVYTCVAENKAGRRTQEATLTVATRPEWVTRPQDS--NLEEGKPGYLHCLARANPPPEVT---WMRNNAVVKPEDPRFEVFPNG-TLRINNVEVYDAHMYSCEARTAGVS--LSAHARVAVLEKLKFTPTPQPSQCLELDKEITIQCSATGMEPPTIRWTKADGGELL-----------PHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGE-IRALVTLIVAVYIRFKLEPENTTVYQGHTAVLHCQATGDPEPRIHWMLK-----EAMLDMKK----NKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNS--------CSIKFLVAQLYVVEKPTHAYDVDEDRAPYKMIQTIGLSVGAAVAYIIVVLGLMFYCKKR 630 HSP 3 Score: 55.8398 bits (133), Expect = 3.838e-7 Identity = 64/292 (21.92%), Postives = 116/292 (39.73%), Query Frame = 3
Query: 531 PTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHP-AGKMDSITPFILNLNDK-NLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDP---LTLMGSESFPNI-------EIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAK 1370
P + +EEGK CLA + +W N+ +K + R+ N TL I++ + D +Y C A+ + + ++ LE P P+ + L+L I ++C + I W EL + Q DG LH ++ S G Y C+ + G++ ++ I+ + + L P N ++Y QG L C Q GDP + M E+ ++ ++ G+L I + + Y C + + V ++Y+ +
Sbjct: 320 PQDSNLEEGKPGYLHCLARANPPPEVTWMRNNAVVKPEDPRFEVFPNGTLRINNVEV-YDAHMYSCEARTAGVSLSAHARVAVLEKLKFTP-------TPQPSQCLELDKEITIQCSATG---MEPPTIRWTKADGGEL-LPHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGEIRALVTLIVAVYIRFKLEPENTTVY--QGHTAVLHC------------QATGDPEPRIHWMLKEAMLDMKKNKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNSCSIKFLVAQLYVVE 585
BLAST of Ptk7 vs. Ensembl Medaka
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:NCBI gene;Acc:101172356]) HSP 1 Score: 204.912 bits (520), Expect = 3.436e-53 Identity = 116/280 (41.43%), Postives = 179/280 (63.93%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNP--NLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++L +PR LQT LGKGEFG+VLLA+A++I++GE +++V+VKSL + +F R+ ++ ++ V +LLG+C E EP ++LEY + GDLKQ+LR + + + + P TK KM++CAQ+A+GME++S R VHKDLAARN L+ Q VK+S L L +D+Y SEY+ ++ P+RW+P E+V ++ S +SDVW+F V WE+FS +P +K +EE+L+ L K+ P C ++ +C ++ P+ RPSFTDI
Sbjct: 730 DKLHFPRANLQTITTLGKGEFGEVLLAKAKSIEEGEEETVVLVKSLQTRDEQLQQDFRREAEMFSKLSHANVVRLLGLCREAEPHYMVLEYYDRGDLKQYLRISKSKDDKVKSQPLSTK-TKMSLCAQVARGMEHLSNHRFVHKDLAARNCLINSQRRVKVSSLSLSKDVYNSEYYHYRQSWIPLRWLPSESVFEDDLSTKSDVWAFGVLMWEVFSHGEMPYSKLDDEEVLEGLKAGKLKLPP--------PEGCPSKIYKLMARCWALGPKERPSFTDI 1000 HSP 2 Score: 155.221 bits (391), Expect = 1.236e-37 Identity = 167/748 (22.33%), Postives = 296/748 (39.57%), Query Frame = 3
Query: 576 CLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQ----GTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAV-FRVYLAKMYEFKREQ---FSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNR-HLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-------RGMVKTIIIVVSCAITYLVLIIGLTVFCSFR 2765
C ++ Y W N E ++++ RR+ + S L DR +D G + C+A+N+++ +S + W+E + + +P ED++ + + L+C P+ + +W+ +G ++ + + TL I+S S G Y C + AG + S F LN+ D++ P E Q C + ++ DPL S + G+L I+Q+ Y C + VA+ + +A++ + + E+ F N + V +G+ P P + W + Q+ P VF+ LV E D G Y NKAG R ++ + V PE+ ++ L E L C + + T W ++ + NG L+I + +Y C ++ G S + ++ + KL+F LE++K+ + C G I+W K + L P+ DG L V + AGNY C A +S+ E I + L+V + EN T+ +G T VL C A GDP P + W + + ++ + N+R + NG+L+I +V D +Y+C A N+ +K L + Y +K ++ M++TI + V A+ Y+++++GL +C R
Sbjct: 4 CEVGNPTDVTYRWLHNGERLEHDERRF--QEGSNLKFTAVDRRLDAGNFVCVAENAATGETAQSSNASFNIKWLESGA-LTLKEPLSEEDIQSSAPVTLRCHIDGHPRPT---CHWYKDGVKLTEKTHQINNKERTLTIKSASPDDSGLYSCCAKNAAGSVCSNPNFTLNIIDESF-PRPVVTPEDQVVMKNEEAVFHCQFTAEPPPTLEWFHENDPL----SNKSRIFLLSNGSLLITQVKPRNTGTYRCVGRGLRGSHVALEASLLIAEIEDMEPEKSLVFQANTQQRVACRPPRGK-----------------------PSPDVWW----------ERGGQRVPAEGRVFQEGLDLVFNPTAEGDSGVYTCVAENKAGRRTQEATLTVATRPEWVTRPQDS--NLEEGKPGYLHCLARANPPPEVT---WMRNNAVVKPEDPRFEVFPNG-TLRINNVEVYDAHMYSCEARTAGVS--LSAHARVAVLEKLKFTPTPQPSQCLELDKEITIQCSATGMEPPTIRWTKADGGELL-----------PHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGE-IRALVTLIVAVYIRFKLEPENTTVYQGHTAVLHCQATGDPEPRIHWMLK-----EAMLDMKK----NKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNS--------CSIKFLVAQLYVVEKPTHAYDVDEDRAPYKMIQTIGLSVGAAVAYIIVVLGLMFYCKKR 670 HSP 3 Score: 55.4546 bits (132), Expect = 5.006e-7 Identity = 64/292 (21.92%), Postives = 116/292 (39.73%), Query Frame = 3
Query: 531 PTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHP-AGKMDSITPFILNLNDK-NLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDP---LTLMGSESFPNI-------EIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAK 1370
P + +EEGK CLA + +W N+ +K + R+ N TL I++ + D +Y C A+ + + ++ LE P P+ + L+L I ++C + I W EL + Q DG LH ++ S G Y C+ + G++ ++ I+ + + L P N ++Y QG L C Q GDP + M E+ ++ ++ G+L I + + Y C + + V ++Y+ +
Sbjct: 360 PQDSNLEEGKPGYLHCLARANPPPEVTWMRNNAVVKPEDPRFEVFPNGTLRINNVEV-YDAHMYSCEARTAGVSLSAHARVAVLEKLKFTP-------TPQPSQCLELDKEITIQCSATG---MEPPTIRWTKADGGEL-LPHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGEIRALVTLIVAVYIRFKLEPENTTVY--QGHTAVLHC------------QATGDPEPRIHWMLKEAMLDMKKNKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNSCSIKFLVAQLYVVE 625
BLAST of Ptk7 vs. Ensembl Medaka
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:NCBI gene;Acc:101172356]) HSP 1 Score: 204.912 bits (520), Expect = 3.867e-53 Identity = 116/280 (41.43%), Postives = 179/280 (63.93%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNP--NLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++L +PR LQT LGKGEFG+VLLA+A++I++GE +++V+VKSL + +F R+ ++ ++ V +LLG+C E EP ++LEY + GDLKQ+LR + + + + P TK KM++CAQ+A+GME++S R VHKDLAARN L+ Q VK+S L L +D+Y SEY+ ++ P+RW+P E+V ++ S +SDVW+F V WE+FS +P +K +EE+L+ L K+ P C ++ +C ++ P+ RPSFTDI
Sbjct: 789 DKLHFPRANLQTITTLGKGEFGEVLLAKAKSIEEGEEETVVLVKSLQTRDEQLQQDFRREAEMFSKLSHANVVRLLGLCREAEPHYMVLEYYDRGDLKQYLRISKSKDDKVKSQPLSTK-TKMSLCAQVARGMEHLSNHRFVHKDLAARNCLINSQRRVKVSSLSLSKDVYNSEYYHYRQSWIPLRWLPSESVFEDDLSTKSDVWAFGVLMWEVFSHGEMPYSKLDDEEVLEGLKAGKLKLPP--------PEGCPSKIYKLMARCWALGPKERPSFTDI 1059 HSP 2 Score: 169.474 bits (428), Expect = 5.066e-42 Identity = 174/781 (22.28%), Postives = 310/781 (39.69%), Query Frame = 3
Query: 477 ISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQ----GTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAV-FRVYLAKMYEFKREQ---FSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNR-HLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-------RGMVKTIIIVVSCAITYLVLIIGLTVFCSFR 2765
SL V+ Y K PT+++ G+ C ++ Y W N E ++++ RR+ + S L DR +D G + C+A+N+++ +S + W+E + + +P ED++ + + L+C P+ + +W+ +G ++ + + TL I+S S G Y C + AG + S F LN+ D++ P E Q C + ++ DPL S + G+L I+Q+ Y C + VA+ + +A++ + + E+ F N + V +G+ P P + W + Q+ P VF+ LV E D G Y NKAG R ++ + V PE+ ++ L E L C + + ++ W ++ + NG L+I + +Y C ++ G S + ++ + KL+F LE++K+ + C G I+W K + L P+ DG L V + AGNY C A +S+ E I + L+V + EN T+ +G T VL C A GDP P + W + + ++ + N+R + NG+L+I +V D +Y+C A N+ +K L + Y +K ++ M++TI + V A+ Y+++++GL +C R
Sbjct: 30 FSLQVLANQAAAIYFTKEPTSQDALHGRSAMLRCEVGNPTDVTYRWLHNGERLEHDERRF--QEGSNLKFTAVDRRLDAGNFVCVAENAATGETAQSSNASFNIKWLESGA-LTLKEPLSEEDIQSSAPVTLRCHIDGHPRPT---CHWYKDGVKLTEKTHQINNKERTLTIKSASPDDSGLYSCCAKNAAGSVCSNPNFTLNIIDESF-PRPVVTPEDQVVMKNEEAVFHCQFTAEPPPTLEWFHENDPL----SNKSRIFLLSNGSLLITQVKPRNTGTYRCVGRGLRGSHVALEASLLIAEIEDMEPEKSLVFQANTQQRVACRPPRGK-----------------------PSPDVWW----------ERGGQRVPAEGRVFQEGLDLVFNPTAEGDSGVYTCVAENKAGRRTQEATLTVATRPEWVTRPQDS--NLEEGKPGYLHCLAR---ANPPPEVTWMRNNAVVKPEDPRFEVFPNG-TLRINNVEVYDAHMYSCEARTAGVS--LSAHARVAVLEKLKFTPTPQPSQCLELDKEITIQCSATGMEPPTIRWTKADGGELL-----------PHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGE-IRALVTLIVAVYIRFKLEPENTTVYQGHTAVLHCQATGDPEPRIHWMLK-----EAMLDMKK----NKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNS--------CSIKFLVAQLYVVEKPTHAYDVDEDRAPYKMIQTIGLSVGAAVAYIIVVLGLMFYCKKR 729
BLAST of Ptk7 vs. Ensembl Medaka
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:NCBI gene;Acc:101172356]) HSP 1 Score: 204.912 bits (520), Expect = 4.008e-53 Identity = 116/280 (41.43%), Postives = 179/280 (63.93%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNP--NLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++L +PR LQT LGKGEFG+VLLA+A++I++GE +++V+VKSL + +F R+ ++ ++ V +LLG+C E EP ++LEY + GDLKQ+LR + + + + P TK KM++CAQ+A+GME++S R VHKDLAARN L+ Q VK+S L L +D+Y SEY+ ++ P+RW+P E+V ++ S +SDVW+F V WE+FS +P +K +EE+L+ L K+ P C ++ +C ++ P+ RPSFTDI
Sbjct: 772 DKLHFPRANLQTITTLGKGEFGEVLLAKAKSIEEGEEETVVLVKSLQTRDEQLQQDFRREAEMFSKLSHANVVRLLGLCREAEPHYMVLEYYDRGDLKQYLRISKSKDDKVKSQPLSTK-TKMSLCAQVARGMEHLSNHRFVHKDLAARNCLINSQRRVKVSSLSLSKDVYNSEYYHYRQSWIPLRWLPSESVFEDDLSTKSDVWAFGVLMWEVFSHGEMPYSKLDDEEVLEGLKAGKLKLPP--------PEGCPSKIYKLMARCWALGPKERPSFTDI 1042 HSP 2 Score: 166.392 bits (420), Expect = 4.224e-41 Identity = 171/770 (22.21%), Postives = 306/770 (39.74%), Query Frame = 3
Query: 510 GFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQ----GTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAV-FRVYLAKMYEFKREQ---FSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNR-HLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-------RGMVKTIIIVVSCAITYLVLIIGLTVFCSFR 2765
Y K PT+++ G+ C ++ Y W N E ++++ RR+ + S L DR +D G + C+A+N+++ +S + W+E + + +P ED++ + + L+C P+ + +W+ +G ++ + + TL I+S S G Y C + AG + S F LN+ D++ P E Q C + ++ DPL S + G+L I+Q+ Y C + VA+ + +A++ + + E+ F N + V +G+ P P + W + Q+ P VF+ LV E D G Y NKAG R ++ + V PE+ ++ L E L C + + ++ W ++ + NG L+I + +Y C ++ G S + ++ + KL+F LE++K+ + C G I+W K + L P+ DG L V + AGNY C A +S+ E I + L+V + EN T+ +G T VL C A GDP P + W + + ++ + N+R + NG+L+I +V D +Y+C A N+ +K L + Y +K ++ M++TI + V A+ Y+++++GL +C R
Sbjct: 24 AIYFTKEPTSQDALHGRSAMLRCEVGNPTDVTYRWLHNGERLEHDERRF--QEGSNLKFTAVDRRLDAGNFVCVAENAATGETAQSSNASFNIKWLESGA-LTLKEPLSEEDIQSSAPVTLRCHIDGHPRPT---CHWYKDGVKLTEKTHQINNKERTLTIKSASPDDSGLYSCCAKNAAGSVCSNPNFTLNIIDESF-PRPVVTPEDQVVMKNEEAVFHCQFTAEPPPTLEWFHENDPL----SNKSRIFLLSNGSLLITQVKPRNTGTYRCVGRGLRGSHVALEASLLIAEIEDMEPEKSLVFQANTQQRVACRPPRGK-----------------------PSPDVWW----------ERGGQRVPAEGRVFQEGLDLVFNPTAEGDSGVYTCVAENKAGRRTQEATLTVATRPEWVTRPQDS--NLEEGKPGYLHCLAR---ANPPPEVTWMRNNAVVKPEDPRFEVFPNG-TLRINNVEVYDAHMYSCEARTAGVS--LSAHARVAVLEKLKFTPTPQPSQCLELDKEITIQCSATGMEPPTIRWTKADGGELL-----------PHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGE-IRALVTLIVAVYIRFKLEPENTTVYQGHTAVLHCQATGDPEPRIHWMLK-----EAMLDMKK----NKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNS--------CSIKFLVAQLYVVEKPTHAYDVDEDRAPYKMIQTIGLSVGAAVAYIIVVLGLMFYCKKR 712
BLAST of Ptk7 vs. Ensembl Medaka
Match: PTK7 (protein tyrosine kinase 7 (inactive) [Source:NCBI gene;Acc:101172356]) HSP 1 Score: 189.889 bits (481), Expect = 1.824e-48 Identity = 99/278 (35.61%), Postives = 155/278 (55.76%), Query Frame = 3
Query: 3228 ERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDI 4061
++L +PR LQT LGKGEFG+VLLA+A++I++GE +++V+VKSL + +F R+ ++ ++ V + L L P+ L +M++CAQ+A+GME++S R VHKDLAARN L+ Q VK+S L L +D+Y SEY+ ++ P+RW+P E+V ++ S +SDVW+F V WE+FS +P +K +EE+L+ L K+ P C ++ +C ++ P+ RPSFTDI
Sbjct: 789 DKLHFPRANLQTITTLGKGEFGEVLLAKAKSIEEGEEETVVLVKSLQTRDEQLQQDFRREAEMFSKLSHANVVR--------------------------LLGLCREAEPHYMVLEYYDRMSLCAQVARGMEHLSNHRFVHKDLAARNCLINSQRRVKVSSLSLSKDVYNSEYYHYRQSWIPLRWLPSESVFEDDLSTKSDVWAFGVLMWEVFSHGEMPYSKLDDEEVLEGLKAGKLKLPP--------PEGCPSKIYKLMARCWALGPKERPSFTDI 1032 HSP 2 Score: 169.859 bits (429), Expect = 3.895e-42 Identity = 174/781 (22.28%), Postives = 310/781 (39.69%), Query Frame = 3
Query: 477 ISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQS-DGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQ----GTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAV-FRVYLAKMYEFKREQ---FSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNR-HLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGI-NSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFN-------RGMVKTIIIVVSCAITYLVLIIGLTVFCSFR 2765
SL V+ Y K PT+++ G+ C ++ Y W N E ++++ RR+ + S L DR +D G + C+A+N+++ +S + W+E + + +P ED++ + + L+C P+ + +W+ +G ++ + + TL I+S S G Y C + AG + S F LN+ D++ P E Q C + ++ DPL S + G+L I+Q+ Y C + VA+ + +A++ + + E+ F N + V +G+ P P + W + Q+ P VF+ LV E D G Y NKAG R ++ + V PE+ ++ L E L C + + ++ W ++ + NG L+I + +Y C ++ G S + ++ + KL+F LE++K+ + C G I+W K + L P+ DG L V + AGNY C A +S+ E I + L+V + EN T+ +G T VL C A GDP P + W + + ++ + N+R + NG+L+I +V D +Y+C A N+ +K L + Y +K ++ M++TI + V A+ Y+++++GL +C R
Sbjct: 30 FSLQVLANQAAAIYFTKEPTSQDALHGRSAMLRCEVGNPTDVTYRWLHNGERLEHDERRF--QEGSNLKFTAVDRRLDAGNFVCVAENAATGETAQSSNASFNIKWLESGA-LTLKEPLSEEDIQSSAPVTLRCHIDGHPRPT---CHWYKDGVKLTEKTHQINNKERTLTIKSASPDDSGLYSCCAKNAAGSVCSNPNFTLNIIDESF-PRPVVTPEDQVVMKNEEAVFHCQFTAEPPPTLEWFHENDPL----SNKSRIFLLSNGSLLITQVKPRNTGTYRCVGRGLRGSHVALEASLLIAEIEDMEPEKSLVFQANTQQRVACRPPRGK-----------------------PSPDVWW----------ERGGQRVPAEGRVFQEGLDLVFNPTAEGDSGVYTCVAENKAGRRTQEATLTVATRPEWVTRPQDS--NLEEGKPGYLHCLAR---ANPPPEVTWMRNNAVVKPEDPRFEVFPNG-TLRINNVEVYDAHMYSCEARTAGVS--LSAHARVAVLEKLKFTPTPQPSQCLELDKEITIQCSATGMEPPTIRWTKADGGELL-----------PHVEQKDGQLHFSKVTRSDAGNYTCIASNSLQGE-IRALVTLIVAVYIRFKLEPENTTVYQGHTAVLHCQATGDPEPRIHWMLK-----EAMLDMKK----NKRFQKMPNGSLVIFDVTTDDTGRYTCVAGNS--------CSIKFLVAQLYVVEKPTHAYDVDEDRAPYKMIQTIGLSVGAAVAYIIVVLGLMFYCKKR 729
BLAST of Ptk7 vs. Planmine SMEST
Match: SMESG000072430.1 (SMESG000072430.1) HSP 1 Score: 2451.01 bits (6351), Expect = 0.000e+0 Identity = 1220/1226 (99.51%), Postives = 1223/1226 (99.76%), Query Frame = 3
Query: 423 MTMFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFXXXXXXXXXXXXXXXXERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 4100
MTMFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQ+DSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPN DKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQ+PPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLG +FNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSS VLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM
Sbjct: 1 MTMFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQMDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNSDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQEPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGGNFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSTVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 1226
BLAST of Ptk7 vs. Planmine SMEST
Match: SMESG000072430.1 (SMESG000072430.1) HSP 1 Score: 2444.85 bits (6335), Expect = 0.000e+0 Identity = 1218/1224 (99.51%), Postives = 1221/1224 (99.75%), Query Frame = 3
Query: 429 MFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFXXXXXXXXXXXXXXXXERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 4100
MFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQ+DSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPN DKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQ+PPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLG +FNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSS VLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM
Sbjct: 1 MFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQMDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNSDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQEPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGGNFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSTVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 1224
BLAST of Ptk7 vs. Planmine SMEST
Match: SMESG000072430.1 (SMESG000072430.1) HSP 1 Score: 2400.16 bits (6219), Expect = 0.000e+0 Identity = 1196/1202 (99.50%), Postives = 1199/1202 (99.75%), Query Frame = 3
Query: 495 GVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQLDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNLDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQKPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGAHFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFXXXXXXXXXXXXXXXXERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 4100
GVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQ+DSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPN DKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQ+PPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLG +FNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSS VLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM
Sbjct: 24 GVTGDGFYLKKSPTNKEVEEGKKVSFDCLAAPSNNIVYSWKINDETIKYNNRRYLGPDNSTLHIDHADRDVDPGVYYCIAQNSSSRFARKSKPGKLEVTWMEPKIEILMLKPERREDLKLTGRILLKCQGVASPKISKENINWFFNGNSELPVGTRVQSDGTLHIESISISHFGFYHCLILHPAGKMDSITPFILNLNDKNLNPTNFSIYEKQGTNVKLTCPWGVGSFVWSKFQRLGDPLTLMGSESFPNIEIKGGTLTISQMDSSGDSYYLCQDADKIKARVAVFRVYLAKMYEFKREQFSPNSDKNVPIVIKKGENGGINFYLDLTSSNSFLFDQIPNPVPIIEWTFQDKEIPKYDINSQEPPPRVHVFRNRHLVIQKAEENDRGTYIIKMHNKAGSRMRKFQIEVTFPPEFADSAENQPLYLNEDDSLSLDCKIKRMASEDTTKIYWKKDGTPIASYMEHLSYENNGRNLKIERAKPEHTGVYQCFIKSLGYSEFHNRQQKIIIKAKLQFIGINSDVFLEVNKDGNMHCKTKGYGKINIKWYKLIFTDPLNSKPTPQLVEPPNEILSDGSLVLKSVQKDYAGNYLCEAKSSMTNEVINKTIKLVVGEKPKILKITENQTIQEGSTLVLDCVAGGDPFPTVSWFMDSPVQGKTLITFESTKSDNERKKVFKNGTLIIKNVALSDEAKYSCFATNNQILSVEEGVVVKVLTPEEYSKQKLGGNFNRGMVKTIIIVVSCAITYLVLIIGLTVFCSFRMLRHRRNRNLTAENLDKLGDNSQLMRPIVGVNPNGGCCAKDKSSSKTSRSVPQNSATVNYLPQVPYSVPPNYYVHYNSSSLPQVGPTYLSNPLIDTNHISEFQHLISAPPPTPLESRSNFSGNMSSTNSASMYTRSHFSSSTNGGVGGMNMNSMERLTYPRHELQTEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLARTECDYVTKLLGICIELEPCLLILEYCEWGDLKQFLRCLQDRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSTVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM 1225
BLAST of Ptk7 vs. Planmine SMEST
Match: SMESG000022068.1 (SMESG000022068.1) HSP 1 Score: 117.857 bits (294), Expect = 1.524e-27 Identity = 91/272 (33.46%), Postives = 137/272 (50.37%), Query Frame = 3
Query: 3270 ILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSEPNYCHEFHRQLDLLART-ECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQ-DRTNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKD 4079
ILG GEFG+V L +A + D +LV VK L + P+ F + D++A + D + K +G + +++EY + G L L+ Q +N N L + +A GME +S + +H+DLAARN+ V+ +KI GL R+ + Y Q E PIRW+ E++L KYS SD+WSF + WEIFS L + E+ DI L + V +L+ P C +I++K RP+FTDI + +KD
Sbjct: 151 ILGSGEFGEVYLGKATSFNDKNKYTLVAVKLLKHNAPS--GNFIMEKDIMANLGDHDNIIKYIGFINLPDKIAIVMEYAKNGSLLNLLKAFQLSPSNTNERILCQ-----FGIDVASGMEYLSSMNLIHRDLAARNVFVSEFWVLKIGDFGLTREA-CNYYRQINEGKVPIRWLALESLLYKKYSTMSDIWSFGILLWEIFS-----LGQTPYHEVTDISLLTDLIVHGK-RNLQ--PVFCRLAIYNIMQKTWHTIASERPTFTDIILELKD 406
BLAST of Ptk7 vs. Planmine SMEST
Match: SMESG000054557.1 (SMESG000054557.1) HSP 1 Score: 120.939 bits (302), Expect = 2.182e-27 Identity = 93/310 (30.00%), Postives = 163/310 (52.58%), Query Frame = 3
Query: 3240 YPRHELQ-TEGILGKGEFGDVLLARARNIQDGESQSLVVVKSLMRSE--PNYCHEFHRQLDLLART-ECDYVTKXXXXXXXXXXXXXXXXXXXWGDLKQFLRCLQDR---TNPNLPYLTKGQKMTMCAQIAKGMENISYIRCVHKDLAARNILVTPQLNVKISHLGLCRDIYQSEYFQDGENIFPIRWMPPEAVLQNKYSIQSDVWSFAVTCWEIFSSIVLPLAKYRNEEILDILTLNNAKVQTMYSSLEQFPSECSHTFLSIIKKCLSIDPQNRPSFTDISVSIKDPSIEVTM*ITR*QQNKFYRGLKN 4148
+PR +L+ T LG+G FG V +I + + V VK +MR + + H+F ++++++ V +LLG+C + P +I+E +G+L+ F+R ++ N+ LT T QIA GM ++ VH+DL+ARNILV +KI+ GL R I Y + + I P++WM PEA+L+ KY+ +SDVWS+ + WEIF+ P + E+++D++ Q ++ E + S+++ C +I +NRP F +I +++D ++ +QN ++ +KN
Sbjct: 516 FPRDKLKITNKKLGEGAFGMVYEGLTNDIAKKPTFTKVAVK-MMRDDFSDSNVHDFVKEMEIMKHIGRHPNVIQLLGLCTQNGPLRVIVELAPYGNLRDFVRSKNNKYSKQKKNIENLTASILSTYSFQIANGMTYLASRSVVHRDLSARNILVGEHYEMKIADFGLTR-IVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDAPYSSILPEKVVDVIKKGFQNPQPELANFEIY---------SLMQHCWNISTENRPHFFEIVETLQDILQRIS---DEPEQNIYHSEMKN 811 The following BLAST results are available for this feature:
BLAST of Ptk7 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Ptk7 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Ptk7 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Ptk7 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Ptk7 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Ptk7 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Ptk7 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Ptk7 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014748 ID=SMED30014748|Name=Ptk7|organism=Schmidtea mediterranea sexual|type=transcript|length=4517bpback to top protein sequence of SMED30014748-orf-1 >SMED30014748-orf-1 ID=SMED30014748-orf-1|Name=SMED30014748-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1227bp MTMFQRNEKDLLLEIVCCISLLVIGVTGDGFYLKKSPTNKEVEEGKKVSFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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