Tetraspanin
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014684 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Tetraspanin vs. Ensembl Fly
Match: Tsp47F (gene:FBgn0033629 transcript:FBtr0088151) HSP 1 Score: 51.6026 bits (122), Expect = 1.444e-7 Identity = 37/117 (31.62%), Postives = 65/117 (55.56%), Query Frame = 2 Query: 209 LLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDF------KVLPASCCPPK 541 +++I++G I+ +++S+G +G + ES +LI + L ++ I+++ I + KK +E +K L K SN+ D+I +K+ CCGV S D+ K LP SCC P+ Sbjct: 54 IVLIVTGLIIFLIASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQE-SIKRSNSEDTMA-WDNIQQKLMCCGVDSPADWRTLSANKTLPGSCCQPQ 168
BLAST of Tetraspanin vs. Ensembl Zebrafish
Match: tspan3a (tetraspanin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-7787]) HSP 1 Score: 48.521 bits (114), Expect = 2.338e-6 Identity = 36/144 (25.00%), Postives = 70/144 (48.61%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC 583 ++II G ++ I+ IG T+ ES+ L I L+++ + ++V +L + +VE + + +N+ + T+ P R D++ +++ CCG+ + D++ +P SCC P V C + YP+GC Sbjct: 54 AVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILMLVFVTEVVVVVLGYIYRAKVEDEVNHSIQKVYNEYNGTNTDAPSRAIDYVQRQLHCCGITNFADWRNTRWFKESKNNSVPLSCCKPNVSNCTGSLLHPGDLYPEGC 197
BLAST of Tetraspanin vs. Ensembl Zebrafish
Match: tspan3a (tetraspanin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-7787]) HSP 1 Score: 48.521 bits (114), Expect = 2.338e-6 Identity = 36/144 (25.00%), Postives = 70/144 (48.61%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC 583 ++II G ++ I+ IG T+ ES+ L I L+++ + ++V +L + +VE + + +N+ + T+ P R D++ +++ CCG+ + D++ +P SCC P V C + YP+GC Sbjct: 54 AVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILMLVFVTEVVVVVLGYIYRAKVEDEVNHSIQKVYNEYNGTNTDAPSRAIDYVQRQLHCCGITNFADWRNTRWFKESKNNSVPLSCCKPNVSNCTGSLLHPGDLYPEGC 197
BLAST of Tetraspanin vs. Ensembl Zebrafish
Match: tspan3a (tetraspanin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-7787]) HSP 1 Score: 48.521 bits (114), Expect = 2.338e-6 Identity = 36/144 (25.00%), Postives = 70/144 (48.61%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC 583 ++II G ++ I+ IG T+ ES+ L I L+++ + ++V +L + +VE + + +N+ + T+ P R D++ +++ CCG+ + D++ +P SCC P V C + YP+GC Sbjct: 54 AVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILMLVFVTEVVVVVLGYIYRAKVEDEVNHSIQKVYNEYNGTNTDAPSRAIDYVQRQLHCCGITNFADWRNTRWFKESKNNSVPLSCCKPNVSNCTGSLLHPGDLYPEGC 197
BLAST of Tetraspanin vs. TrEMBL
Match: B0VZ55 (Tetraspanin OS=Culex quinquefasciatus OX=7176 GN=6030957 PE=3 SV=1) HSP 1 Score: 56.225 bits (134), Expect = 9.600e-6 Identity = 50/175 (28.57%), Postives = 84/175 (48.00%), Query Frame = 2 Query: 170 HTQFGSNTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLY---VFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDF-----KVLPASCC-----PPKVKVCN------FKEAYPQGCFIALKKLVTSNVNYLIPI 637 + F + L +++I+ G + +V+S+G YG + ES +L + LLI+++I++ I K ++ +++ QL HNK+ T+ D ++KKM CCGV D+ K +PASCC P+ + C Y QGC + LK+ N LI + Sbjct: 39 YQHFVEDKLMAPPVVLIVVGAFVFLVASLGCYGAIKESPKLLNTFAVFLLIVLLIEVAVAIAAIAFKSDLQNALERQLQKSIERHNKADMTAW-----DTVHKKMMCCGVQGPKDWYDNNNKTMPASCCKPDLIDPETEDCKNAPPLFMDRYYQQGCLMELKEHFDKNAVVLIAV 208
BLAST of Tetraspanin vs. Ensembl Cavefish
Match: tspan3a (tetraspanin 3 [Source:NCBI gene;Acc:103046031]) HSP 1 Score: 51.6026 bits (122), Expect = 1.432e-7 Identity = 40/152 (26.32%), Postives = 77/152 (50.66%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC-FIALKKL 604 ++II G ++ I+ IG T+ ES+ L I L+++ + ++V +L + +VE+ + + +N+ + T+ P R D++ +++ CCG+ + LD++ +P SCC P V C + YP+GC + +KKL Sbjct: 55 AVVIIAVGGLLFIIGLIGCCATIRESRCGLATFVIILILVFVTEVVVVVLGYIYRAKVEEEVNHSIQKVYNEYNGTNSDAPSRAIDYVQRQLHCCGITNYLDWRNTSWFNESRNNSVPLSCCKPNVSNCTGSLSRPGDLYPEGCEALVVKKL 206
BLAST of Tetraspanin vs. Ensembl Cavefish
Match: tspan3a (tetraspanin 3 [Source:NCBI gene;Acc:103046031]) HSP 1 Score: 51.6026 bits (122), Expect = 1.554e-7 Identity = 40/152 (26.32%), Postives = 77/152 (50.66%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC-FIALKKL 604 ++II G ++ I+ IG T+ ES+ L I L+++ + ++V +L + +VE+ + + +N+ + T+ P R D++ +++ CCG+ + LD++ +P SCC P V C + YP+GC + +KKL Sbjct: 56 AVVIIAVGGLLFIIGLIGCCATIRESRCGLATFVIILILVFVTEVVVVVLGYIYRAKVEEEVNHSIQKVYNEYNGTNSDAPSRAIDYVQRQLHCCGITNYLDWRNTSWFNESRNNSVPLSCCKPNVSNCTGSLSRPGDLYPEGCEALVVKKL 207
BLAST of Tetraspanin vs. Ensembl Cavefish
Match: tspan3a (tetraspanin 3 [Source:NCBI gene;Acc:103046031]) HSP 1 Score: 49.6766 bits (117), Expect = 6.055e-7 Identity = 38/152 (25.00%), Postives = 70/152 (46.05%), Query Frame = 2 Query: 206 GLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR--DHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVCNFK-----EAYPQGC-FIALKKL 604 ++II G ++ I+ IG T+ ES+ +AT++++V SI++ +N+ + T+ P R D++ +++ CCG+ + LD++ +P SCC P V C + YP+GC + +KKL Sbjct: 55 AVVIIAVGGLLFIIGLIGCCATIRESR---------------------CGLATVEEEVNHSIQK----VYNEYNGTNSDAPSRAIDYVQRQLHCCGITNYLDWRNTSWFNESRNNSVPLSCCKPNVSNCTGSLSRPGDLYPEGCEALVVKKL 181
BLAST of Tetraspanin vs. Ensembl Sea Lamprey
Match: tspan3a (tetraspanin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-7787]) HSP 1 Score: 50.447 bits (119), Expect = 9.412e-8 Identity = 43/163 (26.38%), Postives = 77/163 (47.24%), Query Frame = 2 Query: 209 LLIILSGFIMLIVSSIGIYGTVSESK----PXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDFK-----------VLPASCCPPKVKVC--NFK---EAYPQGCFIALKKLVTSNVNYLIPI 637 L+++ G + +V +G TV ESK I L + + ++ ++ +K +VE++I + ++ SNT A D++ ++KCCGV + LD+K +P SCC V C N K + Y +GC ++K V +NY++ + Sbjct: 57 LVVVAVGIFLFVVGIVGCCATVRESKCGLSTFFILLLMIFSLEVVAALLGYAYRGQVKDKVERTISQVFNEYNGTDSNT--ASRAIDYVQHQLKCCGVKNYLDWKDRPWFNHTGNNSVPISCCRSNVTHCDGNIKHPGDIYNEGCEAMVEKTVKDILNYVMRV 217
BLAST of Tetraspanin vs. Planmine SMEST
Match: SMESG000024581.1 (SMESG000024581.1) HSP 1 Score: 284.648 bits (727), Expect = 2.347e-97 Identity = 217/217 (100.00%), Postives = 217/217 (100.00%), Query Frame = 2 Query: 62 MNLTLKFYKXXXXXXXXXXXXXXXXXXXXXXXXXXXHTQFGSNTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDFKVLPASCCPPKVKVCNFKEAYPQGCFIALKKLVTSNVNYLIPIEXXXXXXXXXXXXXXXXXXRMIQQK 712 MNLTLKFYKIFLILLNALFLVFALVLIVGGSIIIGSHTQFGSNTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPILIGLGITLLIMIIIQIVTCILIATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDFKVLPASCCPPKVKVCNFKEAYPQGCFIALKKLVTSNVNYLIPIEIISLLLKVLGIIIIVKYIRMIQQK Sbjct: 1 MNLTLKFYKIFLILLNALFLVFALVLIVGGSIIIGSHTQFGSNTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPILIGLGITLLIMIIIQIVTCILIATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDFKVLPASCCPPKVKVCNFKEAYPQGCFIALKKLVTSNVNYLIPIEIISLLLKVLGIIIIVKYIRMIQQK 217
BLAST of Tetraspanin vs. Planmine SMEST
Match: SMESG000063435.1 (SMESG000063435.1) HSP 1 Score: 50.8322 bits (120), Expect = 1.923e-7 Identity = 48/156 (30.77%), Postives = 80/156 (51.28%), Query Frame = 2 Query: 170 HTQFGSNTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHN--KSSNTSGAFPIRDHINKKMKCCGVVSKLDF-KVLPASCCPPKVKVCNFKEAYPQGCFIALKKLVTSNVNYL 628 TQ ++ + + II++G ++ IV+ +G G + ESK +LI G+ L++++I QI I + + V I +Q+ N K++N + A + D + +CCGV S D+ K +P SCC VCN A+ C A+ V S + L Sbjct: 40 STQLLGSSFSNAPIAIIVAGVVIFIVAFLGCCGAIQESKVMLIIFGVCLIVLLIAQIALSIAVYVYRSNVSTIIGKQMNDAVNIYKTTNDTAARALVDSTQQLFQCCGVNSTSDWGKTVPNSCCQNN-TVCNADTAFKTNCINAMVSKVQSQIGIL 194
BLAST of Tetraspanin vs. Planmine SMEST
Match: SMESG000009559.1 (SMESG000009559.1) HSP 1 Score: 48.9062 bits (115), Expect = 5.872e-7 Identity = 46/153 (30.07%), Postives = 78/153 (50.98%), Query Frame = 2 Query: 185 SNTLFHLG----LLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQLYVFHNKSSNTSGAFPIR----DHINKKMKCCGVVSKLDFKV----LPASCCPPKVKVCNFKEAYPQGCFIALKKLV 607 SNTL + + +I+ G ++ ++S +G+ SESK +L G+ L++++I+Q I+ + ++E SIK L K+ + D I +KCCGV S D+++ +P SCCP K+ CN AY GC ++K + Sbjct: 13 SNTLSNWQSGAPVFVIIVGVLVSLISVLGMAAACSESKCLLATFGMILILILILQFAAAIMAFMARSKMESSIKGLLEKALKKAYTKEKTGKVNTLFFDRIQDDLKCCGVTSVHDYEMIQKPIPESCCPNKIS-CNNNTAYNNGCSNSMKSAI 164
BLAST of Tetraspanin vs. Planmine SMEST
Match: SMESG000019857.1 (SMESG000019857.1) HSP 1 Score: 45.8246 bits (107), Expect = 8.548e-6 Identity = 38/137 (27.74%), Postives = 65/137 (47.45%), Query Frame = 2 Query: 188 NTLFHLGLLIILSGFIMLIVSSIGIYGTVSESKPXXXXXXXXXXXXXXXXXXXXXXXATMKKQVEKSIKEQL-YVFHNKSSNTSGAFPIRDHINKKMKCCGVVSKLDFK-VLPASCCPPKVKVCNFKEAYPQGCFIA 592 N++ + ++I GFI L V+ +G GT+ ++ IL+ L M++ ++ I + Q+ ++K L V N+++ + D + K CCG+ D+ LP+SCC P C A P GC A Sbjct: 53 NSMAPIPFILIALGFIFLAVTVVGFLGTIMKNWIILVTYAGLLGSMVLTEVGAAITCGVFQTQMYSTVKLGLKNVIANQTA-------VMDSVQNKFGCCGINGYQDYNGTLPSSCC-PSTNACTAGLAAPTGCLSA 181 The following BLAST results are available for this feature:
BLAST of Tetraspanin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Tetraspanin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of Tetraspanin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Tetraspanin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Tetraspanin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 1
BLAST of Tetraspanin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of Tetraspanin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Tetraspanin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Tetraspanin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Tetraspanin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014684 ID=SMED30014684|Name=Tetraspanin|organism=Schmidtea mediterranea sexual|type=transcript|length=750bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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