Guanylate cyclase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014646 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944]) HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0 Identity = 291/549 (53.01%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S+ +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSF II QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042 HSP 2 Score: 105.531 bits (262), Expect = 2.977e-22 Identity = 81/366 (22.13%), Postives = 150/366 (40.98%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K PSD P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFSAKNDHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPSDNPPCAFD 442
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 548.895 bits (1413), Expect = 4.009e-176 Identity = 279/513 (54.39%), Postives = 360/513 (70.18%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
+++ + A YKG +V++K++ + KRIE TR++L E+K ++D+ H+ RF+GA D + ++ EYC +GSL+DIL + LDWMF+YSL DI +GM+++HN I HGNLKS+ CVVD RFVLKIT +GL+ D + YA LWTAPE LR + G+ DVYSF II QEI R G F++E +++ KE + ++ + PFRP++ A +E ++ W E+P RP F I+ LRK NR ++ NILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD++++ FDVYKVETIGDAY+V SGLP N HA E+ +MA+A L + +F I HRP QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS TK +L F F + RG VEMKGKG TYWL GE
Sbjct: 551 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQ-----GHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVE-GLDLSPKEIIERVTRGEQPPFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054 HSP 2 Score: 147.132 bits (370), Expect = 4.658e-35 Identity = 102/374 (27.27%), Postives = 169/374 (45.19%), Query Frame = 3
Query: 429 AAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYY-DFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--------KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA------ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPSDTPKCGSDNE 1499
A +GP C Y + R + W+VP++T GA P V+ E + T AG Y + + + + W++ L L+ Y D +C L +R+R LN T F D L+ Y + + IC++P F LM A E G +YVF ++D+F + P+ + ++ I+T K + ++ F + K +A +N + + VN+ A+F+D ++LY +AV + G + + +T+ M N SF GV+G + I+S+GDR +++SL DMD G F V +YNG ++ V ++++W + P D PKCG DNE
Sbjct: 111 AVFLGPGCVYAAAPVGRFTAH-WRVPLLTAGA---PALGFGVKDE-----YALTTRAGPSYAKLGDFVAALHRRLGWER----QALMLYAYRPGDEEHCFFLVEGLFMRVRDR----------LNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYP-PPDIPKCGFDNE 460
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691]) HSP 1 Score: 399.438 bits (1025), Expect = 9.821e-120 Identity = 232/522 (44.44%), Postives = 323/522 (61.88%), Query Frame = 3
Query: 1956 IAVYKGTIVSLKQIK-----SEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRE-SIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTE-RGYVEMKGKGLQLTYWLHGENENIVDPL 3500
IA+Y+G V LK+ K I++ + E+ +KD+ + +I +G DS +V E+CS+GSL+DIL ++ LDWMFK SL+ D+ +GM Y+H+ HG LKS CVVD RFVLK+T +G ND L + +E LLWTAPE LR+ G+ DVYSFAII QE++ R F + + + +E + +LK + P + + E ++++ W E RP F I + + N+ G NI+D++L +EQY++NLE L+ ERTE+ EK++ E LL MLP SVA L + V E +++VT+YFSDIVGFT++SA S P+E+V LLN LYT FD+I+ DVYKVETIGDAY+V SGLPK N + HA EI M++ L + TF + H P+ +++RIG+HSG V AGVVGL MPRYCLFGDTVNT+SRMES+GLP +IH+S ST +L + E RG E+KGKG + T+WL G+ + + PL
Sbjct: 563 IAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEM--MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGF-----NDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMD---LPAQEIINRLK--KPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNK-GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK-KGFMKPL 1070
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689]) HSP 1 Score: 396.356 bits (1017), Expect = 1.520e-118 Identity = 229/535 (42.80%), Postives = 320/535 (59.81%), Query Frame = 3
Query: 1956 IAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIG----------ATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGL-KILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTE-RGYVEMKGKGLQLTYWLHGE---NENIVDP--LNPG 3509
I VY+G V LK+ ++ I KL+++ + ++ ++G A L + VV E+C++GSL+D+LAQ E+ LDWMFK SL+ D+ +G+ Y+H+ HG LKS C+VD RFVLKIT G ++L L E ++Q LWTAPE LR GT+ DV+S AII QE++ R + + E +T +E V +++ P + + D E + ++ W E P RP + +N+ T NI+D++L +EQY++NLE L+ ERTE+ EK++ + LL MLP SVA L V E +E VT+YFSDIVGFT++SA S P+E+V LLN LYT FD+I+ DVYKVETIGDAY+V SGLP+ N HA EI M++ L + TF + H P+ +++RIG+HSG AGVVGL MPRYCLFGDTVNT+SRMES+GLP +IH++ ST +L ++ E RG E+KGKG + T+WL G N+ I P L PG
Sbjct: 552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQ-----LWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLE---LTPEEVVQRVR--SPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPG 1075
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688]) HSP 1 Score: 386.726 bits (992), Expect = 2.725e-115 Identity = 236/558 (42.29%), Postives = 327/558 (58.60%), Query Frame = 3
Query: 1884 SNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELL-----------LEVKKLKDINYHHICRFIGAT-LDSIDKYVVYEYCSKGSLKDILAQ-----NELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYL----EENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEF--VKIVTDAWCENPLNRPDFPTIKSALRK---LNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLC-TFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
S++ ++I ++ + N+ L + TI L+Q K +K+ ++L +E+ KL I+Y+++ +F G LD++ + V EYC +GSL+++L + +DW FK S++ DI +GM Y+H++ HG LKST CVVDSR V+KIT FG SI ++ LWTAPE LR ++ + K DVYS+ II QEII RK FY + NE + E +K PFRP ++ E +V + W E+P RPDF I++ L K L + +D L+ R++ Y+ NLE LV ERT+ Y E+ RA+ L + +LPR V L K V E YE VT+YFSDIVGFT++ STPME+V +LN +Y +FD I++ DVYKVETIGDAY+V SGLPK N N HA +I KMA+ L + TF + H P + +RIG+HSG AGVVG+KMPRYCLFGDTVNT+SRMES+GLPL+IH+S ST +L T F+ RG +KG+G + TYWL G
Sbjct: 469 SHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTM-IFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCN----------SILPPKKD----LWTAPEHLRQ----ANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMK-----PFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 546.969 bits (1408), Expect = 6.461e-174 Identity = 275/544 (50.55%), Postives = 375/544 (68.93%), Query Frame = 3
Query: 1884 SNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI----KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY---PFRPTIYAT------DGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
S S+++IA NN ++Y + A++KG +V++K++ K R++ +R L+E+KK+KD+ + HI RF GA +D VV EYC KGSL+DIL ++ LD + KYSL+ D+ +G+ ++HN+ I HG LKS+ CVVDSRFVLK+T FGL L + + + YY +LWTAPE LR + GT K D+YSFAII E+++RKG F LE NE+++ E V +++ S P RP + T D D + ++ W E+P RP+ +++ A+R LNR +T N++DNLL RMEQYANNLEGLV ERT++YL EK++ E LL+ +LP ++A LI + V AESY+ VT+YFSDIVGFTSLS++STPM++VTLLN LY FD +++ F VYKVETIGDAY+V SGLP+ ++HA +I +M+++ L ++ FVI HRP QLKLRIG+HSG+V AGVVG KMPRYCLFGDTVNTSSRMES+GLPLKIH+S T ++L F + RG VEMKGKG+Q TYWL G
Sbjct: 689 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPE-RRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224 HSP 2 Score: 169.859 bits (429), Expect = 2.030e-42 Identity = 145/539 (26.90%), Postives = 257/539 (47.68%), Query Frame = 3
Query: 165 EIIASKEIINIYVVTPYDRRFP-------FSKNNLEPVTFMANEYIHANKTLTNHSLQFSFLDSDCE----PTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWK--VPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYY----YDFRYCQLFSTALQQLIRERKVKIEMLRK--KLNETAIKSSFKSDLLNEYKNY--------SIFVICTAPSNFIELMDTAKETGF-NNGEYVFINVDLFNNAENLINPFLLTNASKQD----PYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYN-TSYDGE--HVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESR 1676
E I+ K I++ + P D F FS + ++P+ +A E ++ L N+S+ + DS P + L+K + I+G Y ++ +R++ WK +PI+T D+ EY+ +T Y+ + + +F Y W++ I+ +F + C L +LQ +R KV +EM NE + K++ N+++NY ++ ++C +P E+M A + G +GEYVFIN+D+ + + P++ N + + YR + ++L+ D++ NF + K A + YN T+ G+ +N+F++AFYD+++LYA A+ + G D N +T M +FVG++GNV+I+ NGDR S+YSLLD+D F EV+ Y+G + V ++ W + + P+D P CG D +C Y + Y + G + I++++ + + +R K + EL AMSW I + L+ ES+
Sbjct: 36 EEISVKHPIHLVIPLPDDDDFSDGKNPFLFSSHKVKPLADLALERVYREGILPNNSVNLIYRDSKLSDAIGPNVAVEQLLRK---------------QIDCIIGYAYGYALAPVARMSP-YWKNGIPIITPIGLTMSLDDKR-EYQ-------LMTRINSPYKVVSSAVSTLFNTYKWKRHIF-----MFHHAKAPSVAVGECFLLMASLQHPLR--KV-MEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHW-VGGKPPTDLPICGYDKSKCPQGYPLHVYL-LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 546.199 bits (1406), Expect = 8.948e-174 Identity = 275/544 (50.55%), Postives = 375/544 (68.93%), Query Frame = 3
Query: 1884 SNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI----KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY---PFRPTIYAT------DGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
S S+++IA NN ++Y + A++KG +V++K++ K R++ +R L+E+KK+KD+ + HI RF GA +D VV EYC KGSL+DIL ++ LD + KYSL+ D+ +G+ ++HN+ I HG LKS+ CVVDSRFVLK+T FGL L + + + YY +LWTAPE LR + GT K D+YSFAII E+++RKG F LE NE+++ E V +++ S P RP + T D D + ++ W E+P RP+ +++ A+R LNR +T N++DNLL RMEQYANNLEGLV ERT++YL EK++ E LL+ +LP ++A LI + V AESY+ VT+YFSDIVGFTSLS++STPM++VTLLN LY FD +++ F VYKVETIGDAY+V SGLP+ ++HA +I +M+++ L ++ FVI HRP QLKLRIG+HSG+V AGVVG KMPRYCLFGDTVNTSSRMES+GLPLKIH+S T ++L F + RG VEMKGKG+Q TYWL G
Sbjct: 668 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPE-RRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203 HSP 2 Score: 158.688 bits (400), Expect = 6.146e-39 Identity = 123/433 (28.41%), Postives = 215/433 (49.65%), Query Frame = 3
Query: 417 SKRFAAIMGPVCSYTISIFSRLNTNLWK--VPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYS-IFVICTAPSNFIELMDTAKETGF-NNGEYVFINVDLFNNAENLINPFLLTNASKQD----PYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYN-TSYDGE--HVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESR 1676
+K AIMG Y ++ +R+ + W VP+ T A DRN F +T Y+ +L+ + ++ WQ F++ + C +A++ LI K ++ A + +++ LL+E S + ++C +P E+M A + G +GEYVFIN+D+ + + P++ N + + YR + ++L+ D++ NF + K A + YN T+ G+ +N+F++AFYD+++LYA A+ + G D N +T M +FVG++GNV+I+ NGDR S+YSLLD+D F EV+ Y+G + V ++ W + + P+D P CG D +C Y + Y + G + I++++ + + +R K + EL AMSW I + L+ ES+
Sbjct: 99 NKTVDAIMGLPYVYALAPVARI-SKFWGQGVPVFTTTALVDELGDRN--------EFPLLTRMMGSYKSLGKLVTRIAERFEWQHYFFMFNDEVARGPRNKGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRLQYRA-LLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHW-VGGKPPTDLPICGYDKSKCPQGYPLHVYL-LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 546.584 bits (1407), Expect = 2.951e-173 Identity = 275/544 (50.55%), Postives = 375/544 (68.93%), Query Frame = 3
Query: 1884 SNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI----KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY---PFRPTIYAT------DGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
S S+++IA NN ++Y + A++KG +V++K++ K R++ +R L+E+KK+KD+ + HI RF GA +D VV EYC KGSL+DIL ++ LD + KYSL+ D+ +G+ ++HN+ I HG LKS+ CVVDSRFVLK+T FGL L + + + YY +LWTAPE LR + GT K D+YSFAII E+++RKG F LE NE+++ E V +++ S P RP + T D D + ++ W E+P RP+ +++ A+R LNR +T N++DNLL RMEQYANNLEGLV ERT++YL EK++ E LL+ +LP ++A LI + V AESY+ VT+YFSDIVGFTSLS++STPM++VTLLN LY FD +++ F VYKVETIGDAY+V SGLP+ ++HA +I +M+++ L ++ FVI HRP QLKLRIG+HSG+V AGVVG KMPRYCLFGDTVNTSSRMES+GLPLKIH+S T ++L F + RG VEMKGKG+Q TYWL G
Sbjct: 727 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPE-RRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262 HSP 2 Score: 146.362 bits (368), Expect = 4.007e-35 Identity = 95/296 (32.09%), Postives = 163/296 (55.07%), Query Frame = 3
Query: 813 KSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGF-NNGEYVFINVDLFNNAENLINPFLLTNASKQD----PYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYN-TSYDGE--HVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESR 1676
+ +FK L ++ ++C +P E+M A + G +GEYVFIN+D+ + + P++ N + + YR + ++L+ D++ NF + K A + YN T+ G+ +N+F++AFYD+++LYA A+ + G D N +T M +FVG++GNV+I+ NGDR S+YSLLD+D F EV+ Y+G + V ++ W + + P+D P CG D +C P Y + Y + G + I++++ + + +R K + EL AMSW I + L+ ES+
Sbjct: 273 RETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHW-VGGKPPTDLPICGYDKSKC-PGYPLHVYL-LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 498.434 bits (1282), Expect = 1.312e-162 Identity = 262/549 (47.72%), Postives = 367/549 (66.85%), Query Frame = 3
Query: 1872 VSYQSNL--SIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI----KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY---PFRPTIYAT------DGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPL-------KIHISSSTKNLLCTFNTFIMTERGYVEMKGKGL 3449
VS++S S+++IA NN ++Y + A++KG +V++K++ K R++ +R L+E+KK+KD+ + HI RF GA +D VV EYC KGSL+DIL ++ LD + KYSL+ D+ +G+ ++HN+ I HG LKS+ CVVDSRFVLK+T FGL L + + + YY +LWTAPE LR + GT K D+YSFAII E+++RKG F LE NE+++ E V +++ S P RP + T D D + ++ W E+P RP+ +++ A+R LNR +T N++DNLL RMEQYANNLEGLV ERT++YL EK++ E LL+ +LP ++A LI + V AESY+ VT+YFSDIVGFTSLS++STPM++VTLLN LY FD +++ F VYKVETIGDAY+V SGLP+ ++HA +I +M+++ L ++ FVI HRP QLKLRIG+HSG+V AGVVG KMPRYCLFGDTVNTSSRMES+GL + KI+ KN + F+ E+ +E +GK +
Sbjct: 94 VSFKSGSGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPE-RRDDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIEL--DFLKNEKESIEFEGKKM 632
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-21 (Receptor-type guanylate cyclase gcy-21 [Source:UniProtKB/Swiss-Prot;Acc:O16715]) HSP 1 Score: 429.869 bits (1104), Expect = 3.349e-131 Identity = 231/516 (44.77%), Postives = 325/516 (62.98%), Query Frame = 3
Query: 1956 IAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTI----KSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENI 3488
+ +Y+G V+LK+I +E TR + LE+ KL++ ++ F+G + S D +VVYE +GSLKDIL +++ LD +F+ + +DI G+ Y+H++ IG HG LKST C++D+R++++++ FGL+ L G + ++ D Q LWT+PE LR +T S + KSDVYS AI+ E+ R G + E E V + PFRP + + V AW E+PLNRP IK L+ L G I+DN++S +E+Y + LE +AER E+ EK ++E LL MLP VA L NV AES+E TV+FSD GF +SA S P++IV LN LYT FD I++QFDVYKVETI DAY+V SGLP PN N+HA EI + +A LK + +F I H P+ +++LRIG++SG AGVVGLKMPRYCLFGDTVNT+SRMES+G+PL+I+ S + K +L + + ERG VEMKGKG Q+TY++ GEN ++
Sbjct: 511 VGLYEGRTVALKRIYRSD-VEFTRSIRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQED--DVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLT-IGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGENSDM 1022
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151) HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0 Identity = 406/1046 (38.81%), Postives = 579/1046 (55.35%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGF-NNGEYVFINVDLFNNAENLI-------NPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSY-DGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIY----NASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDW-GIKDEIPSDTPKCGSDNERCKPKYEIP-YYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEK-RIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHN-NIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVD------EQYYASLLWTAPERLR-SNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKL-----KYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
A+ G C Y ++ SR ++W+VP++T G + F ++ Y G + ++ + +NW + IY N C L A+ I E V T K+ L N I ++C P + ++M TA+E ++GEYVFIN++LF+ + L N L N Q Y+ + VT K +++ SN+ K IA YN ++ D E +++FV +F+D ++LYA A+ + + + N + + M N SF G++GNVTI++NGDR S YSLLDM+ TTG F V+ + + KEI W G ++E P D P CG D C P +P Y + + ++++ + +R+ +AE+ +MSW + S ++++F D L + H V S L++ S V + + +++ + +++ + V++K ++ + + TR L+LE+K++KD+ + H+ +F GA LD +++ EYC KGSL+DIL + LDWMF+ SL+ DI RGM ++H+ +I HGNLKS+ CVVDSRFVLKIT FGL L R R + D Y++ LLWTAPE LR + + GT K DVY+F II EI R+G FYL + +++++L + PFRP + + I+ W E+P RPDF T+KS +R+ N+ +TGNI+DNLL RME YANNLE LV ERT+ Y EEK++ E LLY +LP+SVA QLI Q V+AE+++ VT+YFSDIVGFT++SAESTPM++V LN LYT FDSI+E FDVYKVETIGDAY+V SGLP N N HAREI ++A+A L+ + F I HRP+ +LKLRIG+H+GA AGVVGLKMPRYCLFGDTVNT+SRMES+G LKIHIS +TK L F TF+ T RG+V MKGKG LTYWL GE
Sbjct: 162 AVFGLPCEYVLAPISRY-ADVWQVPVLTTGGNAKEFNKKSESYS------TLTRLKGAQVNNLGNVVRAILNSFNWTRTALIY---QNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFD---TSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTA---MLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYDGALC-PDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKV---------------------------------------------SLEDVMFR---------DAAERGLRGSFHSLVKQSSQLTLMSEDMVSING--DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLR---RTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187) HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0 Identity = 406/1046 (38.81%), Postives = 579/1046 (55.35%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGF-NNGEYVFINVDLFNNAENLI-------NPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSY-DGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIY----NASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDW-GIKDEIPSDTPKCGSDNERCKPKYEIP-YYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEK-RIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHN-NIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVD------EQYYASLLWTAPERLR-SNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKL-----KYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
A+ G C Y ++ SR ++W+VP++T G + F ++ Y G + ++ + +NW + IY N C L A+ I E V T K+ L N I ++C P + ++M TA+E ++GEYVFIN++LF+ + L N L N Q Y+ + VT K +++ SN+ K IA YN ++ D E +++FV +F+D ++LYA A+ + + + N + + M N SF G++GNVTI++NGDR S YSLLDM+ TTG F V+ + + KEI W G ++E P D P CG D C P +P Y + + ++++ + +R+ +AE+ +MSW + S ++++F D L + H V S L++ S V + + +++ + +++ + V++K ++ + + TR L+LE+K++KD+ + H+ +F GA LD +++ EYC KGSL+DIL + LDWMF+ SL+ DI RGM ++H+ +I HGNLKS+ CVVDSRFVLKIT FGL L R R + D Y++ LLWTAPE LR + + GT K DVY+F II EI R+G FYL + +++++L + PFRP + + I+ W E+P RPDF T+KS +R+ N+ +TGNI+DNLL RME YANNLE LV ERT+ Y EEK++ E LLY +LP+SVA QLI Q V+AE+++ VT+YFSDIVGFT++SAESTPM++V LN LYT FDSI+E FDVYKVETIGDAY+V SGLP N N HAREI ++A+A L+ + F I HRP+ +LKLRIG+H+GA AGVVGLKMPRYCLFGDTVNT+SRMES+G LKIHIS +TK L F TF+ T RG+V MKGKG LTYWL GE
Sbjct: 162 AVFGLPCEYVLAPISRY-ADVWQVPVLTTGGNAKEFNKKSESYS------TLTRLKGAQVNNLGNVVRAILNSFNWTRTALIY---QNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFD---TSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTA---MLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYDGALC-PDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKV---------------------------------------------SLEDVMFR---------DAAERGLRGSFHSLVKQSSQLTLMSEDMVSING--DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLR---RTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG3216 (gene:FBgn0034568 transcript:FBtr0273396) HSP 1 Score: 598.201 bits (1541), Expect = 0.000e+0 Identity = 382/1058 (36.11%), Postives = 577/1058 (54.54%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHG--FKFITAAGYHYQDPAELIIEMFIKYNWQKFI--YFSTLNLFDYYYD---FRYCQLFSTALQQLIRE--RKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFI-ELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSY-DGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDW-GIKDEIPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVY--EYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHN-NIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFV-DEQYYASLLWTAPERLRSNT--QFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVIISNLHVP 3539
A +GP C++ + +RL W PI+T P + + G G K+ ++D ++ + Y + I + S + F++ + +LFS + + + R+ + K+LN + + L + Y+ VI + + + M A G NGE+VF++V++F + + + + Y + V+L S F +F++ + A DYN ++ +GE VN F+ AFYD + L A+ + +G DI + +T M N +F G++G+V I+ NGDR+++YS+LD+D G FS V+ Y+G+ K+Y+ V K+I W G ++E P D P CG ++ C + Y + G + ++ ++IC++ + K EL MSW + D + L + +G M + SK G+ + + IS H S S S+ ++Y I +KG V++K++ K+++ T +LL E+K+ +D+++ + RF+GA +D V+ EYCS+GSLKD+L + LDW F+ SLI DI +GM Y+HN ++ HG L+S C++D RFVLKI+ FGL+ L+ S FV D+ YY LLW APE L T T + DVYSF II +EI+ R G Y E + M + K++ Q FRP I + C + ++++ W +N RP F TI+S +R + + G N++D+LL+RMEQYANNLE LV E+T Q EK+R E LLY +LPR VA QL+ V E + VT+YFSDIVGFT L A S+PM++V LN LY+TFD I+ +DVYKVETIGDAY+V SGLP+PN + HAREI MA+ L+ + +F + H+P+ ++++RIG+HSG+VCAGVVG KMP YCLFGDTVNT+SRMES+G P KIH+SS+TK +L F TF M +RG VE+KGKG TYWL+ +E P P I++ VP
Sbjct: 161 AFIGPACAFALEPVARLAA-YWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGLLSFVKELNGN--EEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQ-KQMKLSKELNNMSWRVRPD--DVL------------IEMGGM------------------FGSKG------GLQRLDVENISLQQFGIHSGRASIASFTSLPP------------QVYTTIGQFKGERVAIKKVNV-KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLT-----TPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGP-YQEARQQMDVHTILHKVR--QCNGFRPLIRERE-CPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMK-GFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTP--QILTTDEVP 1151
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302487) HSP 1 Score: 514.612 bits (1324), Expect = 1.610e-161 Identity = 348/995 (34.97%), Postives = 531/995 (53.37%), Query Frame = 3
Query: 630 IIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKK---LNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETG-FNNGEYVFINVDL--FNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKA-KRIARRDYN-----TSYDG-EHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSG-NVTINSNGDRNSEYSLLDMD-------------RTTGNF-SEVSSYNGITKIYAQVK---EIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYY--FXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYAS----LLWTAPERLRSN-TQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLK-YLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENE 3482
++ + + +NW + F+Y + +Y + T L L + V I +R + + + F++ + Y N I++I + LM + + G + G+Y + +D+ ++ A E + LL + +P ++ + + S F F+N+ K + R +N + G + +++ A YD++ LYA+A+ +V G N S + A+ + G +V I+ NGD Y++L R G F SS + I+K +K IDW + P+ P+CG E+C + Y A++L+ ++ +V++RN +++ EL ++ W I +R + EN R Q S K+ + + L + + PL + + Q +LS + A +++ I + I +YKG + ++K+++ +K ++ TRE+ E+K L+D + +IC FIGA D + ++ EYC++GSLKDIL ++ LD MF S++ DI RG+IY+H++ I HG L ++ C+VDSR+V+K+T FGL E D Q+ ++ LL+ APE LR + GT + D YSF I+ E+ R+G F M +KV++ + YL P+RP++ + D + + + W E P +RPDF TI++ LR L R G NI DN+++ ME+YANNLE LV +RT+Q EEK++ + LL+ MLPR VA QL + V E YE V++YFSDIVGFT++SAE TP+++V LN LYT FDSI+ +DVYKVETIGDAY+V SGLP N + HA EI M++ L + F I HRP +L LRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMESSG+PLKIH S + LL + ERG + MKGKG Q TYWL GE+E
Sbjct: 171 VVALLLAFNWTQVSFLYLDDAS-------GQYQPVAETILSTLT-DAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDV---EPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW-VGGTRPAAAPRCGFGGEKC-----VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID----------FREVQIHEN--------------------EREQQSQKQTRHLLNHLPRRLPPQSTHPLIR------TSQVSLSSNPDADFRYTTI-----FTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGI---EDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLN--PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPL-RKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1100
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792) HSP 1 Score: 511.146 bits (1315), Expect = 3.122e-160 Identity = 347/995 (34.87%), Postives = 528/995 (53.07%), Query Frame = 3
Query: 630 IIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKK---LNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETG-FNNGEYVFINVDL--FNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKA-KRIARRDYN-----TSYDG-EHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSG-NVTINSNGDRNSEYSLLDMD-------------RTTGNF-SEVSSYNGITKIYAQVK---EIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYY--FXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYAS----LLWTAPERLRSN-TQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLK-YLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENE 3482
++ + + +NW + F+Y + +Y + T L L + V I +R + + + F++ + Y N I++I + LM + + G + G+Y + +D+ ++ A E + LL + +P ++ + + S F F+N+ K + R +N + G + +++ A YD++ LYA+A+ +V G N S + A+ + G +V I+ NGD Y++L R G F SS + I+K +K IDW + P+ P+CG E+C + Y A++L+ ++ +V++RN +++ EL ++ W I +R + EN R Q S K+ + + PL + + Q +LS + A +++ I + I +YKG + ++K+++ +K ++ TRE+ E+K L+D + +IC FIGA D + ++ EYC++GSLKDIL ++ LD MF S++ DI RG+IY+H++ I HG L ++ C+VDSR+V+K+T FGL E D Q+ ++ LL+ APE LR + GT + D YSF I+ E+ R+G F M +KV++ + YL P+RP++ + D + + + W E P +RPDF TI++ LR L R G NI DN+++ ME+YANNLE LV +RT+Q EEK++ + LL+ MLPR VA QL + V E YE V++YFSDIVGFT++SAE TP+++V LN LYT FDSI+ +DVYKVETIGDAY+V SGLP N + HA EI M++ L + F I HRP +L LRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMESSG+PLKIH S + LL + ERG + MKGKG Q TYWL GE+E
Sbjct: 171 VVALLLAFNWTQVSFLYLDDAS-------GQYQPVAETILSTLT-DAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDV---EPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW-VGGTRPAAAPRCGFGGEKC-----VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID----------FREVQIHEN--------------------EREQQSQKQT-------------RSTHPLIR------TSQVSLSSNPDADFRYTTI-----FTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGI---EDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLN--PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPL-RKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1087
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 657.136 bits (1694), Expect = 0.000e+0 Identity = 417/1114 (37.43%), Postives = 605/1114 (54.31%), Query Frame = 3
Query: 174 ASKEIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFV-ICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK--IYAQVKEIDWGIKDEIPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLE--TLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
AS++ I + V+ P ++ +P++ + P + A E ++++ L + LQ F S+ + S + + S A +GP C Y+ S +R T+ W+VP++T GA GF+ + IT G ++ E ++ M + W K + L D D R C +RE + + L +E ++ +LL + + + V +C F +LM GF EY F +DLF + + P+ +A +++V I+T + + ++ +F +K K A +N + + +N +F+D ++LY+ A+ + +V + M N ++ GV+G V ++ NGDR +++L DM D TG++ VS YNG K I ++ W +K P D P+CG +DN C K + I + I+++ + V I+R K + EL A W + + ++ E RR K +S+ N Y S L++D N ++Y + YKG I ++K + ++KRIE TR++L E+K ++D+ H+ RFIGA +D + ++ EYC +GSL+D++ + LDWMF+YSLI DI +GM ++HN+ I HGNLKS+ CVVDSRFVLKIT +GL+ + L + +YA LWTAPE LR++ + GT K DVYSF II QE+ KG FYLE ++ KE + ++ +P+ + ++E +++ W E+ RPDF IK LRK N G NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPME+VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI +M++A L+ + +F I HRP+ QL+LRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S +T+ +L FN F + RG VEMKGKG TYWL GE
Sbjct: 42 ASQKNITLAVILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDL------KFSYNPWAFIGPGCDYSSSPVARFTTH-WEVPMITSGARAL-----------GFNLYSSITNIGPTHKKLGEFVLRMHRHFGWDKH---AMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYD---ELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW-LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRRACSKLTISLRGSN---------------------------------------------------YGSLLTMDG----------NFQIYAKTGYYKGNITAIKYV-NKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNLDDV----HAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLE-GPCLSPKEIIERV-VEGRWPYLRPLLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 657.136 bits (1694), Expect = 0.000e+0 Identity = 417/1114 (37.43%), Postives = 605/1114 (54.31%), Query Frame = 3
Query: 174 ASKEIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFV-ICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK--IYAQVKEIDWGIKDEIPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLE--TLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
AS++ I + V+ P ++ +P++ + P + A E ++++ L + LQ F S+ + S + + S A +GP C Y+ S +R T+ W+VP++T GA GF+ + IT G ++ E ++ M + W K + L D D R C +RE + + L +E ++ +LL + + + V +C F +LM GF EY F +DLF + + P+ +A +++V I+T + + ++ +F +K K A +N + + +N +F+D ++LY+ A+ + +V + M N ++ GV+G V ++ NGDR +++L DM D TG++ VS YNG K I ++ W +K P D P+CG +DN C K + I + I+++ + V I+R K + EL A W + + ++ E RR K +S+ N Y S L++D N ++Y + YKG I ++K + ++KRIE TR++L E+K ++D+ H+ RFIGA +D + ++ EYC +GSL+D++ + LDWMF+YSLI DI +GM ++HN+ I HGNLKS+ CVVDSRFVLKIT +GL+ + L + +YA LWTAPE LR++ + GT K DVYSF II QE+ KG FYLE ++ KE + ++ +P+ + ++E +++ W E+ RPDF IK LRK N G NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPME+VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI +M++A L+ + +F I HRP+ QL+LRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S +T+ +L FN F + RG VEMKGKG TYWL GE
Sbjct: 42 ASQKNITLAVILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDL------KFSYNPWAFIGPGCDYSSSPVARFTTH-WEVPMITSGARAL-----------GFNLYSSITNIGPTHKKLGEFVLRMHRHFGWDKH---AMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYD---ELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW-LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRRACSKLTISLRGSN---------------------------------------------------YGSLLTMDG----------NFQIYAKTGYYKGNITAIKYV-NKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNLDDV----HAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLE-GPCLSPKEIIERV-VEGRWPYLRPLLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 575.089 bits (1481), Expect = 0.000e+0 Identity = 374/1096 (34.12%), Postives = 572/1096 (52.19%), Query Frame = 3
Query: 228 PFSKNNLEPVTFMANEYIHAN-KTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNV--EYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERK----VKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIE-LMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS--IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSY-DGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
PFS + +A ++++ + L H L + ++D +C R K + +++A +GP CS ++ ++L W + +++ Q F D+ R F F + A +E+ ++ WQ YD + + E K + + L++ + +S S +LNE + ++ +A + L+ A + G NG++VF + + + L F D + Y+ +F ++L + FS ++ D+ +Y E V+ A +D++ LYA A+ + + + Y+ VT M N + G+ G+VTI+++GDR Y + + + V++Y G K V+ + G P D+P CG E C E + +G I+ + + V++R K E M W I+++ + +E + +K + S Q S + I+ + DK S H + Y+ +I V F N+ + L ELL E+K+ +D+ ++++C+FIGA L++ +++ EYC KGSL+DIL + LDW FK+SL+ DI +GM Y+H++ + HG+L S+ CVVDSRFVLK+T FGL + RL + +LLW APE LR + ++GT K DVYSFAII QE++YR+G FY+ N + + +E V +++ P RP I + C +E +V W E P RPDF I++A++K + G + NILD+LLSRMEQYA NLE +V+ERT + EEK+RAE LL MLPRSVA QLI + V AE+Y+ VT+YFSDI GFT++SA TPM++V +LN LYT FD+I++ +VYKVETIGDAY+V SGLP N ++HA+EI +M++A ++ L +F PH P++QL++RIG+HSG AGVVGLKMPRYCLFGDTVNT+SRMES GLPLKIH+SSSTK+LL TF F RG + +KGKG T+WL GE+
Sbjct: 34 PFSSGRIGAGALIAISSVNSSPELLRGHHLDYHYVDDECNDL-----------RGPGKIAALYNRHKYSAFIGPSCSNVCAVTAKLAA-FWNIAVISPVCADQQFLDKKAYPTLTRVFGPFTKLGA----------FFVEICKQFGWQHI---------GIIYDGKPTWAIPVEGIKYQAEHNNITVAKYQDIHSSLSQGS--TSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQ-KVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFGTYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCI-NLERKFLIALGIIAGLMAAGTLAICVLYRKYKLPEEASKMLWTINANDVIMMEHHSSTVPEKSHRS------------------KPLQASLESIICS-------MQDKPSA------HRTAVYKG-----TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVR---RLDTEQSPGSDPWTALLWRAPELLRQSIP-ANGTQKGDVYSFAIIAQEVVYRRGPFYI-PNSHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 1027
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4]) HSP 1 Score: 561.992 bits (1447), Expect = 0.000e+0 Identity = 290/524 (55.34%), Postives = 371/524 (70.80%), Query Frame = 3
Query: 1911 GVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
G + N +++ + +KG IV++K I + +R+E TR++L E+K ++D+ H+ RFIGA +D + +V EYC +GSL++IL + + LDWMFKYSLI DI +GM ++HN+ I HGNLKS+ CVVD+RFVLKIT +GL + ++ YYA LW APE R GT K DVYSF II QE+ R+G FYLE + ++ KE V ++ L +P+ RP++ ++E +++ W E P +RP+F I LRK NR + NILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTP+++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRPD QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMES+G PLKIH+SS+T+ +L FN F + RG VEMKGKG TYWL GE
Sbjct: 298 GSLLTTDGNFQVFAKTGYFKGNIVAIKYI-NRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESDTEDA----HSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLE-GDLLSPKEIVDRVA-LGEWPYLRPSL-NPQAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812 HSP 2 Score: 105.145 bits (261), Expect = 2.034e-22 Identity = 82/294 (27.89%), Postives = 141/294 (47.96%), Query Frame = 3
Query: 870 ICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVK--EIDWGIKDEIPSDTPKCGSDNER--CKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLET--LESRYRRISKKENLSVGSMN 1724
+C +P F +L+ + G EYVF +D+F ++ P+ ++ +++V I+T + ++ +F K A+R +N + D +N FYD ++LY A+ + + + V++ M N ++ GV+G V I+ NGDR ++++L DM D TG+F V+ YNG K + I W ++P D P CG NE C+ + + I + + +I++ + V I+R K + EL A W IS D ++ LE R K LS+ N
Sbjct: 4 VCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWP-GGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSN 296
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 557.37 bits (1435), Expect = 1.808e-179 Identity = 366/1082 (33.83%), Postives = 562/1082 (51.94%), Query Frame = 3
Query: 228 PFSKNNLEPVTFMANEYIHAN-KTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNV--EYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERK----VKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIE-LMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS--IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSY-DGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMK 3437
PFS + +A ++++ + L H L + ++D +C R K + +++A +GP CS ++ ++L W + +++ Q F D+ R F F + A +E+ ++ WQ YD + + E K + + L++ + +S S +LNE + ++ +A + L+ A + G NG++VF + + + L F D + Y+ +F ++L + FS ++ D+ +Y E V+ A +D++ LYA A+ + + + Y+ VT M N + G+ G+VTI+++GDR Y + + + V++Y G K V+ + G P D+P CG E C E + +G I+ + + V++R K E M W I+++ + +E + +K + S Q S + I+ + DK S H + Y+ +I V F N+ + L ELL E+K+ +D+ ++++C+FIGA L++ +++ EYC KGSL+DIL + LDW FK+SL+ DI +GM Y+H++ + HG+L S+ CVVDSRFVLK+T FGL + RL + +LLW APE LR + ++GT K DVYSFAII QE++YR+G FY+ N + + +E V +++ P RP I + C +E +V W E P RPDF I++A++K + G + NILD+LLSRMEQYA NLE +V+ERT + EEK+RAE LL MLPRSVA QLI + V AE+Y+ VT+YFSDI GFT++SA TPM++V +LN LYT FD+I++ +VYKVETIGDAY+V SGLP N ++HA+EI +M++A ++ L +F PH P++QL++RIG+HSG AGVVGLKMPRYCLFGDTVNT+SRMES GLPLKIH+SSSTK+LL TF F RG + +K
Sbjct: 34 PFSSGRIGAGALIAISSVNSSPELLRGHHLDYHYVDDECNDL-----------RGPGKIAALYNRHKYSAFIGPSCSNVCAVTAKLAA-FWNIAVISPVCADQQFLDKKAYPTLTRVFGPFTKLGA----------FFVEICKQFGWQHI---------GIIYDGKPTWAIPVEGIKYQAEHNNITVAKYQDIHSSLSQGS--TSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQ-KVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFGTYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCI-NLERKFLIALGIIAGLMAAGTLAICVLYRKYKLPEEASKMLWTINANDVIMMEHHSSTVPEKSHRS------------------KPLQASLESIICS-------MQDKPSA------HRTAVYKG-----TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVR---RLDTEQSPGSDPWTALLWRAPELLRQSIP-ANGTQKGDVYSFAIIAQEVVYRRGPFYI-PNSHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIK 1013
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 552.362 bits (1422), Expect = 0.000e+0 Identity = 294/552 (53.26%), Postives = 382/552 (69.20%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTD-AWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGK------GLQLTYWLHG 3473
S+ +H + + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RF+GA +D + +V EYC +GSL+DIL + LDWMF+ SLI DI +GM ++H +I G HGNLKS+ CVVDSRFVLKIT +GL R S D+ Y YA LWTAPE LR + GT K DVYSF II QEI R G FY++ +++ KE V K++ Q FRPT+ + C E + I+ D W E PL+RPDF IK+ + K N+ G T +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IHISS+TK +L F+ F + RG +EMK K GL L HG
Sbjct: 23 SERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVKIPLVATGLGLHTRCHG 563
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 551.977 bits (1421), Expect = 0.000e+0 Identity = 292/546 (53.48%), Postives = 381/546 (69.78%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTD-AWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
S+ +H + + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RF+GA +D + +V EYC +GSL+DIL + LDWMF+ SLI DI +GM ++H +I G HGNLKS+ CVVDSRFVLKIT +GL R S D+ Y YA LWTAPE LR + GT K DVYSF II QEI R G FY++ +++ KE V K++ Q FRPT+ + C E + I+ D W E PL+RPDF IK+ + K N+ G T +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IHISS+TK +L F+ F + RG +EMK K + L HG
Sbjct: 153 SERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK-IPLVSLSHG 686
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 551.592 bits (1420), Expect = 0.000e+0 Identity = 289/536 (53.92%), Postives = 377/536 (70.34%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTD-AWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGK 3443
S+ +H + + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RF+GA +D + +V EYC +GSL+DIL + LDWMF+ SLI DI +GM ++H +I G HGNLKS+ CVVDSRFVLKIT +GL R S D+ Y YA LWTAPE LR + GT K DVYSF II QEI R G FY++ +++ KE V K++ Q FRPT+ + C E + I+ D W E PL+RPDF IK+ + K N+ G T +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IHISS+TK +L F+ F + RG +EMK K
Sbjct: 181 SERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 550.051 bits (1416), Expect = 0.000e+0 Identity = 289/536 (53.92%), Postives = 377/536 (70.34%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTD-AWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGK 3443
S+ +H + + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RF+GA +D + +V EYC +GSL+DIL + LDWMF+ SLI DI +GM ++H +I G HGNLKS+ CVVDSRFVLKIT +GL R S D+ Y YA LWTAPE LR + GT K DVYSF II QEI R G FY++ +++ KE V K++ Q FRPT+ + C E + I+ D W E PL+RPDF IK+ + K N+ G T +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IHISS+TK +L F+ F + RG +EMK K
Sbjct: 108 SERYHKTAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 548.895 bits (1413), Expect = 0.000e+0 Identity = 286/515 (55.53%), Postives = 369/515 (71.65%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTD-AWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHG 3473
+++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RF+GA +D + +V EYC +GSL+DIL + LDWMF+ SLI DI +GM ++H +I G HGNLKS+ CVVDSRFVLKIT +GL R S D+ Y YA LWTAPE LR + GT K DVYSF II QEI R G FY++ +++ KE V K++ Q FRPT+ + C E + I+ D W E PL+RPDF IK+ + K N+ G T +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H REI +M++A L+ + TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IHISS+TK +L F+ F + RG +EMK K + L HG
Sbjct: 107 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK-IPLVSLSHG 609
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0 Identity = 292/549 (53.19%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSFAII QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 1042 HSP 2 Score: 103.219 bits (256), Expect = 1.172e-21 Identity = 80/366 (21.86%), Postives = 150/366 (40.98%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA+ + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K P D P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPLDNPPCAFD 442
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0 Identity = 292/549 (53.19%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSFAII QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 70 SDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 608
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371]) HSP 1 Score: 556.599 bits (1433), Expect = 2.937e-179 Identity = 281/513 (54.78%), Postives = 366/513 (71.35%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
+++ + A YKG +V++K++ + KRIE TR++L E+K ++D+ H+ RF+GA D + ++ EYC +GSL+DIL + LDWMF+YSL DI +GM+++HN IG HGNLKS+ CVVD RFVLKIT +GL+ S D E +A LWTAPE LR + + G+ DVYSF II QEI R G FY+E +++ KE + ++ + PFRP++ +E +++ W E+P RP F I+ ALRK N+ ++ NILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD++++ FDVYKVETIGDAY+V SGLP N HARE+ +MA+A L + +F I HRP QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IH+SS TK +L F+ F + RG VEMKGKG TYWL GE
Sbjct: 547 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLE--SFRDPEPEQ---GHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIERVTRGEQPPFRPSM-DLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050 HSP 2 Score: 139.813 bits (351), Expect = 5.712e-33 Identity = 98/367 (26.70%), Postives = 170/367 (46.32%), Query Frame = 3
Query: 429 AAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNW--QKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFN----NAENLI--NPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKE--IDWGIKDEIPSDTPKCGSDNE 1499
A +GP C Y+ + R + W+VP++T GA P V+ E + T G + + + + + W Q + ++ D D R C L +RER + I + ++ E + L + + IC++P F LM A + G +YVF ++D+F A+ + P+ + + ++ I+T K + ++ F + K +A + +N + + N A+F+D ++LY +AV + QG + + +T+ M N SF GV+G + I+ NGDR++++SL DMD TG F V ++NG ++ V E + W + P D PKCG DNE
Sbjct: 107 AVFLGPGCVYSAAPVGRFTAH-WRVPLLTAGA---PALGIGVKDE-----YALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYA-----DRLGDDRPCFFIVEGLYMRVRER-LNITVNHQEFVE-GDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYP-PPDIPKCGFDNE 456
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 458.759 bits (1179), Expect = 1.589e-142 Identity = 239/470 (50.85%), Postives = 321/470 (68.30%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSG 3248
S +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSFAII QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G
Sbjct: 504 SDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963 HSP 2 Score: 103.219 bits (256), Expect = 1.047e-21 Identity = 80/366 (21.86%), Postives = 150/366 (40.98%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA+ + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K P D P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPLDNPPCAFD 442
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2e (guanylate cyclase 2e [Source:MGI Symbol;Acc:MGI:105123]) HSP 1 Score: 413.69 bits (1062), Expect = 4.931e-125 Identity = 236/569 (41.48%), Postives = 336/569 (59.05%), Query Frame = 3
Query: 1854 QNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIG----ATLDSIDK------YVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGL-KILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNT-FIMTERGYVEMKGKGLQLTYWLHGE---NENIVDP--LNPG 3509
Q S++ +S I S+ + N + +Y+G V LK+ E + KL+++ + ++ ++G T DS VV E+C++GSL D+LAQ E+ LDWMFK SL+ D+ +GM Y+H+ HG LKS CVVD RFVLK+T G ++L L E ++Q LWTAPE LR + GT+ DV+S AII QE++ R + + E +T +E + +++ P + + D E ++++T W E+P RP + +N+ T NI+D++L +EQY++NLE L+ ERTE+ +EK++ + LL MLP SVA L +V E +E VT+YFSDIVGFT++SA S P+E+V LLN LYT FD+I+ DVYKVETIGDAY+V SGLP+ N HA EI M++ L + +F + H P+ +++RIG+HSG AGVVGL MPRYCLFGDTVNT+SRMES+GLP +IH++ ST +L + F M RG E+KGKG++ TYWL G N+ I P L PG
Sbjct: 528 QGSRSSLATRSASDIRSVPSQPQESTN-------VGLYEGDWVWLKKFPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQ-----LWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLE---LTPEEVIQRVR--SPPPLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPG 1078
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2) HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0 Identity = 292/549 (53.19%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSFAII QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKG 1042 HSP 2 Score: 103.219 bits (256), Expect = 8.198e-21 Identity = 80/366 (21.86%), Postives = 150/366 (40.98%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA+ + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K P D P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFAAKNEHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPLDNPPCAFD 442
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16067|ANPRB_RAT (Atrial natriuretic peptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Npr2 PE=1 SV=1) HSP 1 Score: 566.229 bits (1458), Expect = 0.000e+0 Identity = 292/549 (53.19%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSFAII QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042 HSP 2 Score: 102.449 bits (254), Expect = 1.527e-20 Identity = 80/366 (21.86%), Postives = 149/366 (40.71%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W +P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA+ + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K P D P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WHLPLLTAGAVASGFAAKNEHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYTREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPLDNPPCAFD 442
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P20594|ANPRB_HUMAN (Atrial natriuretic peptide receptor 2 OS=Homo sapiens OX=9606 GN=NPR2 PE=1 SV=1) HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0 Identity = 291/549 (53.01%), Postives = 381/549 (69.40%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S+ +H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSF II QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042 HSP 2 Score: 105.531 bits (262), Expect = 1.430e-21 Identity = 81/366 (22.13%), Postives = 150/366 (40.98%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS---------IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F +N Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + P T QD + ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K PSD P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFSAKNDHY-------RTLVRTGPSAPKLGEFVVTLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLR-AGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGAPPSDNPPCAFD 442
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P46197|ANPRB_BOVIN (Atrial natriuretic peptide receptor 2 OS=Bos taurus OX=9913 GN=NPR2 PE=2 SV=1) HSP 1 Score: 564.688 bits (1454), Expect = 0.000e+0 Identity = 291/549 (53.01%), Postives = 380/549 (69.22%), Query Frame = 3
Query: 1851 SQNHHDSVSYQSNLSI-DSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNI-GPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
S+ H + LS+ S G + +++ +KG +V++K + ++KRIE TR++L E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + + LDWMF+YSLI D+ +GM ++HN+I HG+LKS+ CVVDSRFVLKIT +GL R + D+ + YA LWTAPE L N ++G K+DVYSF II QEI R G FYLE +++ KE V K++ Q FRP+I T +E V ++ W ++P RPDF IK +R+ N+ G T +ILDNLL RMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA EI +MA+A L + +F I HRP QL+LRIG+H+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK+ L F + RG VEMKGKG TYWL GE +
Sbjct: 504 SERCHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIASHGSLKSSNCVVDSRFVLKITDYGLA------SFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 1042 HSP 2 Score: 100.908 bits (250), Expect = 4.739e-20 Identity = 78/365 (21.37%), Postives = 150/365 (41.10%), Query Frame = 3
Query: 435 IMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA------ENLINPFL--LTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK-IYAQVKEIDWGIKDEIPSDTPKCGSD 1493
++GP C Y + +R ++ W++P++T GA F ++ Y + + G E ++ + +NW + L D D R + + ++ + ++ ++ + + + N I IC E++ A+ NG+YVF +D+F + ++ P+ T Q ++ V ++T + + ++ F N+ AR D+ +N FYD I+LYA + + +G + + E M + GV+G V ++ N DR +++ L M D +G+F + Y+G K I+ + I W +K P D P C D
Sbjct: 96 LLGPGCVYPAASVARFASH-WRLPLLTAGAVASGFSAKSEHY-------RTLVRTGPSAPKLGEFVVMLHGHFNWTAR---AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQ------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRSMGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYRGVTGLVVMDKNNDRETDFVLWAMGDLVSGDFQPAAHYSGAEKQIWWTGRPIPW-VKGVPPLDNPPCAFD 442
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2) HSP 1 Score: 556.599 bits (1433), Expect = 2.055e-178 Identity = 281/513 (54.78%), Postives = 366/513 (71.35%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
+++ + A YKG +V++K++ + KRIE TR++L E+K ++D+ H+ RF+GA D + ++ EYC +GSL+DIL + LDWMF+YSL DI +GM+++HN IG HGNLKS+ CVVD RFVLKIT +GL+ S D E +A LWTAPE LR + + G+ DVYSF II QEI R G FY+E +++ KE + ++ + PFRP++ +E +++ W E+P RP F I+ ALRK N+ ++ NILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTPM++VTLLN LYT FD++++ FDVYKVETIGDAY+V SGLP N HARE+ +MA+A L + +F I HRP QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G L+IH+SS TK +L F+ F + RG VEMKGKG TYWL GE
Sbjct: 547 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLE--SFRDPEPEQ---GHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIERVTRGEQPPFRPSM-DLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050 HSP 2 Score: 139.813 bits (351), Expect = 3.996e-32 Identity = 98/367 (26.70%), Postives = 170/367 (46.32%), Query Frame = 3
Query: 429 AAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNW--QKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFN----NAENLI--NPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKE--IDWGIKDEIPSDTPKCGSDNE 1499
A +GP C Y+ + R + W+VP++T GA P V+ E + T G + + + + + W Q + ++ D D R C L +RER + I + ++ E + L + + IC++P F LM A + G +YVF ++D+F A+ + P+ + + ++ I+T K + ++ F + K +A + +N + + N A+F+D ++LY +AV + QG + + +T+ M N SF GV+G + I+ NGDR++++SL DMD TG F V ++NG ++ V E + W + P D PKCG DNE
Sbjct: 107 AVFLGPGCVYSAAPVGRFTAH-WRVPLLTAGA---PALGIGVKDE-----YALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYA-----DRLGDDRPCFFIVEGLYMRVRER-LNITVNHQEFVE-GDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYP-PPDIPKCGFDNE 456
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 830.091 bits (2143), Expect = 0.000e+0 Identity = 481/1119 (42.98%), Postives = 678/1119 (60.59%), Query Frame = 3
Query: 252 PVTFMANEYIHANKTLTNHSLQFSFLDSDCE--PTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLN-TNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK-------FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKN-YSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQ---DPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQK-VFIQG-KDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPS-DTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLE--SRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKE-----ILFENF----GINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIK-SEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDE-----FVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPL 3500
PV +A E + L HS+ DS C+ VL L + ++ ++GP CS+ ++ +R N ++ PI+T G RD+ EY F I G + +++ +F ++NW+ FI ++ + S L I + V+ + + ++L + FKS++ ++ + V+C P E+M A+E GF NGEYVF N+DLF++ + + P+ N + + YR + +TL+ S ++ NFS + K IA+ YN +Y E VNSFV AF+D++ILYA A+ V+ G + I N S++TE M N +F G++G V+IN+NGDR+++YSLLDMD+ T NF V+ Y G + Y V KEIDW +D +P D PKCG D CK + V + + I ++ ++ VI+R + ++EL AM+W I LE +E + RR S+ + +++ + + + R Q K ILF N +K D+ Q+ + S +S+D+IAGV S I +L+ + A YKG +V+LK + KRIE T +LL+EVK++KD+ ++ RFIGA LD+ ++ +V EYC KGSL+D+L + L LDWMFK+SL+ DICRGMIY+H+N G HGNLKS+ C+VDSRF LKI FGL+ L G ++ + Y + LWTAPE LR+ T GT + DVYSFAIICQEIIYR+G F++ + + +E V K+K + + +RPT+ A D+ + V + W E+P RP F +IKS + + N+ ++GNILDNLL RMEQY+NNLE LVA+RT+ YLEEK++AE LLY MLP+SVA L+R ++V AE ++ VT+YFSDI GFT+LS+ESTP+E+VTLLN LYT FD I+EQ+D YKVETIGDAY+V SGLP N HAREI +MA++FL+ +++F I H+PD QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+GLPLKIHISS T +L F+ T RG VEMKGKG QLTYWLHGE ++IVDP+
Sbjct: 8 PVVDIAIETVTTLDLLHGHSVSLIANDSKCDYSVAPVLGVLL--------------LQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDK-AEY------FNLIRV-GPSFDGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQYEMHNAQFKSEIFRVMRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGK-DLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPV 1103
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267FJR9 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025214g3 PE=3 SV=1) HSP 1 Score: 818.92 bits (2114), Expect = 0.000e+0 Identity = 482/1118 (43.11%), Postives = 667/1118 (59.66%), Query Frame = 3
Query: 246 LEPVTFMANEYIHANKTLTNH-SLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKY--NWQKFIYFS-----TLNLFDYYYDFRYCQLFSTALQQLIR-ERKVKIE------MLRKKLNETAIKSSFKSDLLNEY--KNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINP-FLLTNASKQDPYS--IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQG--KDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPS-DTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI-KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRS-NTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYL--QSYPFRPTIYAT----DG-CTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDP 3497
L PV +A ++ + L + +LQ ++D CE L + T + S RF I+G CSY ++ + +V+ GA + + T A Y+ + FI+ W Y + T L YY DF C+L AL ++ E + E ++ + + SS +L+E +S+ V+C P E+M A E GF NGEYVF N+DLF++ P + T++++++ + YR + +TL+ S ++ +FS+K K A+++Y+ Y E VNSFV AF+D+++LYA A+ I N S++T M + +F G++G V+IN+NGDRN++YSLLDMD+ T NF+ V+ Y G TK Y V K IDW KD +P D PKCG DN RCK + V + + I ++ ++ VI+R + ++EL AM+W I+ LE E R + S + ++ Q +E N N+ ++ D VS SN S+++IAGV S I +L+ + A YKG +V+LKQI KR+E ++L+E+K++KD+ +I RFIGA LDS ++ +V EYC KGSL+DIL + L LDWMFK+SL+ DICRGMIY+H++ G HGNLKS+ C+VDSRF LKI FGL L G+ L+E D Y + LWTAPE LR+ +T + GT + DVYSF II QEIIYRKG FY+ + + ++ + K++ PFRP++ DG + IV W E+P RP+F +KS + + N+ ++GNILDNLL RMEQY+NNLE LVA RT+QYLEEK++AE LLY MLP+ VA L++ ++V AE ++ VT+YFSDI GFT+LS+ESTPME+V LLN LYT FD I+EQ+D YKVETIGDAY+V SGLP N N HAREI +M+++FL+ +F+F I H+PD QLKLRIG+HSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+GLPLKIHISS T +L F+ TERG VEMKGKGLQ TYWLHGEN+NIVDP
Sbjct: 63 LRPVFHVAKQHQLVRQALADRINLQEVYVDFGCEHNVSLKQIINLTCAQRSSGRETSTEPRF--IVGVPCSYPMNNVQQYMLQPTDA-VVSTGAISSNLVNMK-------QTIRIGTTADEIYK-----ALRAFIRNLGRWSGMFYVTMNNVMTKRLPHYYLDFVQCKLIQQALDHHLKLEPSFRYEYVYVDSLIEEGRQNDSSTSSLYRRILHERVSTKFSVVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGVIYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNEQQQQDEDPAIAPKGSDVVS--SNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1163
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8JDN4 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 813.142 bits (2099), Expect = 0.000e+0 Identity = 469/1050 (44.67%), Postives = 648/1050 (61.71%), Query Frame = 3
Query: 441 GPVCSYTISIFSRLNTN-LWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQL----------FSTALQQLIRERKVKIE--MLRKKLNETAIKSSFKSDLLNEYKN-YSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINP-FLLTNASKQDPYS--IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQG--KDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPS-DTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQI-KSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRS-NTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYL--QSYPFRPTIYAT----DG-CTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDP 3497
GP C++ ++ +R N L++ PI+T GA N+E + ++ + + D +++ +F +YNW + NL Y QL FS L+ I R +LR K +A F+S++ + + V+C P E+M A E GF NGEYVF N+DLF++ P + T++++++ + YR + +TL+ S ++ +FS+K K A+++Y+ Y E VNSFV AF+D+++LYA A+ I N S++T M + +F G++G V+IN+NGDRN++YSLLDMD+ T NF+ V+ Y G TK Y V K IDW KD +P D PKCG DN RCK + V + + I ++ ++ VI+R + ++EL AM+W I+ LE E R + S + ++ Q +E N N+ ++ D VS SN S+++IAGV S I +L+ + A YKG +V+LKQI KR+E ++L+E+K++KD+ +I RFIGA LDS ++ +V EYC KGSL+DIL + L LDWMFK+SL+ DICRGMIY+H++ G HGNLKS+ C+VDSRF LKI FGL L G+ L+E D Y + LWTAPE LR+ +T + GT + DVYSF II QEIIYRKG FY+ + + ++ + K++ PFRP++ DG + IV W E+P RP+F +KS + + N+ ++GNILDNLL RMEQY+NNLE LVA RT+QYLEEK++AE LLY MLP+ VA L++ ++V AE ++ VT+YFSDI GFT+LS+ESTPME+V LLN LYT FD I+EQ+D YKVETIGDAY+V SGLP N N HAREI +M+++FL+ +F+F I H+PD QLKLRIG+HSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+GLPLKIHISS T +L F+ TERG VEMKGKGLQ TYWLHGEN+NIVDP
Sbjct: 37 GPFCTFCLAAVARYNRYYLYQKPIITSGAAA------NLEDKEEYYNLIRVGPMNF---DIENMLLAIFQRYNW---LPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVK-PYSATNKHFQSEVFRCMREEVRLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGVIYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNEQQQQDEDPAIAPKGSDVVS--SNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HYF3 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 813.142 bits (2099), Expect = 0.000e+0 Identity = 478/1117 (42.79%), Postives = 672/1117 (60.16%), Query Frame = 3
Query: 252 PVTFMANEYIHANKTLTNHSLQFSFLDSDCE--PTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLN-TNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK-------FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKN-YSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQ---DPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQK-VFIQG-KDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPS-DTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLE--SRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKE-----ILFENF----GINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIK-SEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEF---VKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPL 3500
PV +A E + L HS+ DS C+ VL L + ++ ++GP CS+ ++ +R N ++ PI+T G RD+ EY F I G + +++ +F ++NW+ FI ++ + S L I + V+ + + ++L + FKS++ ++ + V+C P E+M A+E GF NGEYVF N+DLF++ + + P+ N + + YR + +TL+ S ++ NFS + K IA+ YN +Y E VNSFV AF+D++ILYA A+ V+ G + I N S++TE M N +F G++G V+IN+NGDR+++YSLLDMD+ T NF V+ Y G + Y V KEIDW +D +P D PKCG D CK + V + + I ++ ++ VI+R + ++EL AM+W I LE +E + RR S+ + +++ + + + R Q K ILF N +K D+ Q+ + S +S+D+IAGV S I +L+ + A YKG +V+LK + KRIE T +LL+EVK++KD+ ++ RFIGA LD+ ++ +V EYC KGSL+D+L + L LDWMFK+SL+ DICRGMIY+H+N G HGNLKS+ C+VDSRF LKI FGL+ L G ++ + Y + LWTAPE LR+ T GT + DVYSFAIICQEIIYR+G F++ + + +E V K+K + + +RPT+ A D+ I T P F +IKS + + N+ ++GNILDNLL RMEQY+NNLE LVA+RT+ YLEEK++AE LLY MLP+SVA L+R ++V AE ++ VT+YFSDI GFT+LS+ESTP+E+VTLLN LYT FD I+EQ+D YKVETIGDAY+V SGLP N HAREI +MA++FL+ +++F I H+PD QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+GLPLKIHISS T +L F+ T RG VEMKGKG QLTYWLHGE ++IVDP+
Sbjct: 8 PVVDIAIETVTTLDLLHGHSVSLIANDSKCDYSVAPVLGVLL--------------LQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDK-AEY------FNLIRV-GPSFDGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQYEMHNAQFKSEIFRVMRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGK-DLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTKLLAGGPSRPASFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPV 1101
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267GXV3 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000254g3 PE=3 SV=1) HSP 1 Score: 803.512 bits (2074), Expect = 0.000e+0 Identity = 439/911 (48.19%), Postives = 598/911 (65.64%), Query Frame = 3
Query: 858 SIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQ---DPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQK-VFIQG-KDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQV--KEIDWGIKDEIPS-DTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLE--SRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKE-----ILFENF----GINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIK-SEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVD-----EQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDE-----FVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPL 3500
++ V+C P E+M A+E GF NGEYVF N+DLF++ + + P+ N + + YR + +TL+ S ++ NFS + K IA+ YN +Y E VNSFV AF+D++ILYA A+ V+ G + I N S++TE M N +F G++G V+IN+NGDR+++YSLLDMD+ T NF V+ Y G + Y V KEIDW +D +P D PKCG D CK + V + + I ++ ++ VI+R + ++EL AM+W I LE +E + RR S+ + +++ + + + R Q K ILF N +K D+ Q+ + S +S+D+IAGV S I +L+ + A YKG +V+LK + KRIE T +LL+EVK++KD+ ++ RFIGA LD+ ++ +V EYC KGSL+D+L + L LDWMFK+SL+ DICRGMIY+H+N G HGNLKS+ C+VDSRF LKI FGL+ L G ++ + Q+Y L WTAPE LR+ T GT + DVYSFAIICQEIIYR+G F++ + + +E V K+K + + +RPT+ A D+ + V + W E+P RP F +IKS + + N+ ++GNILDNLL RMEQY+NNLE LVA+RT+ YLEEK++AE LLY MLP+SVA L+R ++V AE ++ VT+YFSDI GFT+LS+ESTP+E+VTLLN LYT FD I+EQ+D YKVETIGDAY+V SGLP N HAREI +MA++FL+ +++F I H+PD QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+GLPLKIHISS T +L F+ T RG VEMKGKG QLTYWLHGE ++IVDP+
Sbjct: 256 AVVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGK-DLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRRQFYDKL-WTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPV 1164
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0 Identity = 428/1117 (38.32%), Postives = 621/1117 (55.60%), Query Frame = 3
Query: 183 EIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESK--QISKRFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDE-IPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
EII + V+ P + +P++ + P A + +++N +L +SLQF F S + T CS++ + + +FA A +GP C YT S T+ W +P++T GA F DR+ Y IT G ++ E + + + W + + L D R C L ++E V I + E + ++ L + + +C +P F +LM ++ E+VFI +D+F + P+ +A + Y++V I+T + + ++ +F K A++ +N + D +N FYD ++LY +A+ + + ++ +TE M N ++ GV+G V I+ +GDR ++++L DM D + F V+ YNG K + + + IP D P CG +DN C + + + + ++++ I V I+R K + EL A W RIS ++ Q S+ E + + G K++ L + +Y S L+ D N +++ + A +KG IV++K + + KRIE TR++L E+K ++D+ H+ RFIGA +D + +V EYC +GSL+DIL + LDWMFKYSLI DI +GM ++HN+ I HGNLKS+ CVVD+RFVLKIT +GL ++ YYA LW AP+ LR + + GT K D+YSF II QE+ R+G FY+E ++++ KE V ++ L +P+ RPT+ T ++E +++ W E P RP+F IK LRK NR + +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI +M++A L + TF I HRPD+QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMES+G PLKIH+SS++ ++L FN F + RG VEMKGKG TYWL GE+++
Sbjct: 47 EIIKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESS------------ENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTS-------ITNTGPTHKKLGEFALHICRHFGWSQH---ALLMFGDSKMGERECYFAVEGLYTELKE--VNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLW---------------RISWED-----------------------MQMSNLEKVLRSAG------SKLTLSLRGS-----NYGSLLTAD----------GNFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPEDA----HSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIE-GDSLSPKEIVDRVA-LGEWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1070
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0 Identity = 428/1117 (38.32%), Postives = 621/1117 (55.60%), Query Frame = 3
Query: 183 EIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESK--QISKRFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDE-IPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
EII + V+ P + +P++ + P A + +++N +L +SLQF F S + T CS++ + + +FA A +GP C YT S T+ W +P++T GA F DR+ Y IT G ++ E + + + W + + L D R C L ++E V I + E + ++ L + + +C +P F +LM ++ E+VFI +D+F + P+ +A + Y++V I+T + + ++ +F K A++ +N + D +N FYD ++LY +A+ + + ++ +TE M N ++ GV+G V I+ +GDR ++++L DM D + F V+ YNG K + + + IP D P CG +DN C + + + + ++++ I V I+R K + EL A W RIS ++ Q S+ E + + G K++ L + +Y S L+ D N +++ + A +KG IV++K + + KRIE TR++L E+K ++D+ H+ RFIGA +D + +V EYC +GSL+DIL + LDWMFKYSLI DI +GM ++HN+ I HGNLKS+ CVVD+RFVLKIT +GL ++ YYA LW AP+ LR + + GT K D+YSF II QE+ R+G FY+E ++++ KE V ++ L +P+ RPT+ T ++E +++ W E P RP+F IK LRK NR + +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI +M++A L + TF I HRPD+QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMES+G PLKIH+SS++ ++L FN F + RG VEMKGKG TYWL GE+++
Sbjct: 47 EIIKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESS------------ENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTS-------ITNTGPTHKKLGEFALHICRHFGWSQH---ALLMFGDSKMGERECYFAVEGLYTELKE--VNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLW---------------RISWED-----------------------MQMSNLEKVLRSAG------SKLTLSLRGS-----NYGSLLTAD----------GNFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPEDA----HSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIE-GDSLSPKEIVDRVA-LGEWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1070
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 632.484 bits (1630), Expect = 0.000e+0 Identity = 413/1117 (36.97%), Postives = 604/1117 (54.07%), Query Frame = 3
Query: 183 EIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESK--QISKRFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDE-IPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
EII + V+ P + +P++ + P A + +++N +L +SLQF F S + T CS++ + + +FA A +GP C YT S T+ W +P++T GA F DR+ Y IT G ++ E + + + W + + L D R C L ++E V I + E + ++ L + + +C +P F +LM ++ E+VFI +D+F + P+ +A + Y++V I+T + + ++ +F K A++ +N + D +N FYD ++LY +A+ + + ++ +TE M N ++ GV+G V I+ +GDR ++++L DM D + F V+ YNG K + + + IP D P CG +DN C + + + + ++++ I V I+R K + EL A W RIS ++ Q S+ E + + G K++ L + +Y S L+ D N +++ + A +KG IV++K + + KRIE TR++L E+K ++D+ H+ RFIGA +D + +V EYC +GSL + GM ++HN+ I HGNLKS+ CVVD+RFVLKIT +GL ++ YYA LW AP+ LR + + GT K D+YSF II QE+ R+G FY+E ++++ KE V ++ L +P+ RPT+ T ++E +++ W E P RP+F IK LRK NR + +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI +M++A L + TF I HRPD+QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMES+G PLKIH+SS++ ++L FN F + RG VEMKGKG TYWL GE+++
Sbjct: 27 EIIKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESS------------ENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTS-------ITNTGPTHKKLGEFALHICRHFGWSQH---ALLMFGDSKMGERECYFAVEGLYTELKE--VNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLW---------------RISWED-----------------------MQMSNLEKVLRSAG------SKLTLSLRGS-----NYGSLLTAD----------GNFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL----------------------VLSGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPEDA----HSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIE-GDSLSPKEIVDRVA-LGEWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNRE-VSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1028
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 630.558 bits (1625), Expect = 0.000e+0 Identity = 412/1117 (36.88%), Postives = 601/1117 (53.80%), Query Frame = 3
Query: 183 EIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESK--QISKRFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDE-IPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
EII + V+ P + +P++ + P A + +++N +L +SLQF F S + T CS++ + + +FA A +GP C YT S T+ W +P++T GA F DR+ Y IT G ++ E + + + W + + L D R C L ++E V I + E + ++ L + + +C +P F +LM ++ E+VFI +D+F + P+ +A + Y++V I+T + + ++ +F K A++ +N + D +N FYD ++LY +A+ + + ++ +TE M N ++ GV+G V I+ +GDR ++++L DM D + F V+ YNG K + + + IP D P CG +DN C + + + + ++++ I V I+R K + EL A W RIS ++ Q S+ E + + G K++ L + +Y S L+ D N +++ + A +KG IV++K + + KRIE TR++L E+K ++D+ H+ RFIGA +D + +V EYC +GSL+DIL + LDWMFKYSLI DI +GM ++HN+ I HGNLKS+ CVVD+RFVLKIT +GL ++ YYA LW AP+ LR + + GT K D+YSF II QE+ R+G FY+E ++++ KE V ++ L +P+ RPT+ T ++E +++ W E P RP+F IK LRK NR + +ILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTPM+ VETIGDAY+V SGLP N HAREI +M++A L + TF I HRPD+QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMES+G PLKIH+SS++ ++L FN F + RG VEMKGKG TYWL GE+++
Sbjct: 66 EIIKLAVILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESS------------ENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTH-WGLPMITAGAPAVGFSDRSDAYTS-------ITNTGPTHKKLGEFALHICRHFGWSQH---ALLMFGDSKMGERECYFAVEGLYTELKE--VNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLW---------------RISWED-----------------------MQMSNLEKVLRSAG------SKLTLSLRGS-----NYGSLLTAD----------GNFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPEDA----HSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIE-GDSLSPKEIVDRVA-LGEWPYLRPTV-NTQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNRE-VSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQ-----------------------VETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1066
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 545.428 bits (1404), Expect = 4.181e-175 Identity = 278/517 (53.77%), Postives = 363/517 (70.21%), Query Frame = 3
Query: 1932 NNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
N ++Y + YKG I ++K + ++KRIE TR++L E+K ++D+ H+ RFIGA +D+ + ++ EYC +GSL+D++ + LDWMF+YSLI DI +GM ++HN+ I HGNLKS+ C+VDSRFVLKIT +GL L ++ YYA LWTAPE +R + GT K DVYSF II QE+ KG FYL+ + + KE V + +P+ + T ++E +++ W E+ RPDF IK L K NR G NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT++SAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H EI +M++A L+ +++F I HRPD QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S +T+ +L FN F + RG +EMKGKG TYWL GE+
Sbjct: 540 GNVQIYAKTCYYKGNITAIKYV-NKKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFRKESYLEDT----HAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLD-SPPFSPKEIVEHVAE-GRWPYLRPLLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGES 1048 HSP 2 Score: 112.464 bits (280), Expect = 1.458e-24 Identity = 100/416 (24.04%), Postives = 183/416 (43.99%), Query Frame = 3
Query: 189 INIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISK--RFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQL-FSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYS-IFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNA--ENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSY 1400
I + ++ P + +P++ + P A E ++++ TL + +Q F S + CS + + ++ +FA A +GP C Y S +R T+ W+VP+VT GA GF+ + IT G ++ E ++ M + W K+ + + D D R C ++ + +M+ NE S+ +DL+N + +C F +LM + EYVF +DLF + P+ +A + +++V I+T + + ++ +F +K KR A++++N S + +N F+D ++LY+ A+ + Q +VT+ M N +F GV+G V ++ NGDR +++L DM T EV Y
Sbjct: 25 ITLAIILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSS------------ENKEGLCSDSVAPLVAVDLKFAHDPWAFIGPGCDYASSPVARFTTH-WEVPMVTAGAPAL-----------GFNMYSSITNTGPTHKKLGEFVVRMHHNFGWHKY---AMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMV---FNEDDEPLSY-ADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEVFIY 409
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 548.125 bits (1411), Expect = 1.169e-179 Identity = 285/517 (55.13%), Postives = 363/517 (70.21%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLK-DILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGC-TDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENE 3482
+++ + Y+G +V++K I ++K+IE TRE+L E+K ++D+ H+ RF+GA +D + +V EYC +GSL+ DIL + LDW+F+YSLI DI +GM+++HN+ IG HG+LKS+ CVVDSRFVLKIT +GL + YA LWTAPE LR GT K DVYS II QEI R G FY+E +++ KE V K+K Q FRP+ + C +E ++ W E+P RPDF IK + K N+ T NILDNLLSRMEQYANNLE LV ERT+ YLEEKR+AETLLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTSLSAESTPM++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N +A+EI +M++A L + TF I HR + +LKLRIGIH+G VCAGVVGLKMPR+CLFGDTVNT+SRMES+G LKIH+S +TK +L F F + RG VEMKGKG TYWL GE E
Sbjct: 315 QMFAKTGYYRGNLVAIKPI-NKKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSECEDM----HSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVE-GMDLSPKEIVQKVKNGQRPYFRPS--TDESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNKENST-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGEIE 822 HSP 2 Score: 119.013 bits (297), Expect = 1.841e-27 Identity = 83/296 (28.04%), Postives = 146/296 (49.32%), Query Frame = 3
Query: 858 SIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFN------NAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVK--EIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLE--TLESRYRRISKKENLSV 1712
S+ C + + F + M A G G+YVF VD F+ N P+ + + Y+ V I++ + + ++ +F K K+ A+ +N + + +N +FYD+I++Y A+ K G +++ +T+ M N ++ GV+G TI+ NGDR +++SL D+ D TG F+ V SY+G + +V EI W IP D P CG +NE C ++ S+ +++V + +I+R K + EL +M W + + ++ +LE R K LS+
Sbjct: 5 SVVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPWKRGDEFDEQAKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWP-GGSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARRSAGSKLTLSM 299
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 529.25 bits (1362), Expect = 6.697e-177 Identity = 272/512 (53.12%), Postives = 353/512 (68.95%), Query Frame = 3
Query: 1968 KGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPF-RPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTG------NILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
+G +V + I + K+IE TR++L E+K ++D+ H+ RF+GA +D + ++ EYC +GSL+DIL + LDWMF+YSL+ DI +GM+Y+H++ IG HGNLKS+ CVVDSRFVLKIT +GL + + + S Y+ LWTAPE LR GT K DVYSFAII QEI R G FYLE N ++T KE V ++K L +P+ RPT+ G ++E ++ W E RPDF IK L+K + D ILDNLLSRMEQYANNLE LV ERT+ YLEEK +AE LLY +LP SVA QL R + V AE+++ VT+Y SDIVGFT++SA+STPM++V LN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HA E+ +MA+A L + F I HRP ++L LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRME+ G +IH+SS+TK +L + F++ G V++KGKG TYWL GEN
Sbjct: 1 QGNLVEIPFI-NRKKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKADSS----ANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEAN-HLTAKEIVQRVK-LGEWPYLRPTV-DPGGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002650.1 (pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 gene:ENSPMAG00000002416.1 transcript:ENSPMAT00000002650.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 404.06 bits (1037), Expect = 3.365e-129 Identity = 214/507 (42.21%), Postives = 319/507 (62.92%), Query Frame = 3
Query: 1971 GTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRK----GQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
G V+LK+I+ +K T+ + EVK+++++ Y ++C+FIG ++ + ++ EYC KGSL+D+L +++ L+W F++S DI RGM ++H++ HG LKST CV+D R+V KI +GL+ +D L E + S ++ PER+ S + T +DVYS+ +I EI R+ Y ++ T ++ + ++ ++ T G + K++ W NPL RP F IK L K+N + + +D ++S ME+Y+ +LE +V ERT+ + EK++ + LLYSMLP+ +A L + + A+SY TV+FSDIVGFT LS+ STP E+V LNKLYT+FD I++ +DVYKVETIGDAY+V SG+P N N HA E MA+ + FVIPH+P+ QLK+R GIH+G V AGVVG KMPRYCLFGDTVNT+SRMES+ LKI S ST ++L +++++ RG V +KGKG +T+WL G +
Sbjct: 1 GRTVALKKIE-KKAFNLTKVIRREVKQVRELEYANLCKFIGGMVEVPNVAILTEYCPKGSLQDVLLNDDIPLNWGFRFSFATDIARGMAFLHSHRLFHGRLKSTNCVIDDRWVCKIADYGLEEYRKDD-LAE--YATTHKPKSWVYLPPERIVSKNTEPAPT--TDVYSYGVILVEIATRQTPTPAGLYSPHDDAETEGPPPSPPPPIRPFIYK-SVRCTIGSAYYYNKLIQKCWNHNPLLRPTFEQIKKFLHKMN--PNKFSPVDMMMSLMEKYSKHLESVVTERTQDLVLEKQKTDRLLYSMLPKQIADDLRQGRVTKAQSYASATVFFSDIVGFTQLSSSSTPYEVVDFLNKLYTSFDGIIDNYDVYKVETIGDAYMVVSGVPTENHNQHAVETANMALDLVNVCQAFVIPHKPEMQLKIRAGIHTGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSPSTSSILQQIGSYLLSCRGTVTVKGKGEMITWWLEGRD 498
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 404.06 bits (1037), Expect = 2.296e-126 Identity = 225/516 (43.60%), Postives = 319/516 (61.82%), Query Frame = 3
Query: 1956 IAVYKGTIVSLKQIK--SEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGL-KILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQ-----FYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
I +Y+G V+LK ++ +++ R L K++++ + ++ F G ++ + +V +YC KGSLKD+L ++ LDWMFK S DI GMI++H + I HGNLK + C++DSR +K+TGFG+ + G I ++ L WTAPE LR +GT K DV+SFAI+ +E+IY + + +LE + + + + P RP + T+ C ++ W E+ RPDF ++ LR + GD NILDN++S++E+YAN+LE +V +RT Q EK++ + LL S+LP V QL + V E YE+VT++F DIVGFT++SA STP+E++ LLN LY D I++++DVYKVETIGDAY+V SGLP N H EI M++ FL + F I H P QLKLRIGI+SG V AGVVG MPRYCLFGDTVN +SRMES+G PL IH+S +T NLL + + ERG + +KGKG QLTYWL G+
Sbjct: 214 IGIYQGNQVALKFLERTHPPDLKSNRFAL----KMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYVGIHLEPKDIIDQVRDGIAVP-----PLRPLL--TERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDM-NILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717 HSP 2 Score: 50.8322 bits (120), Expect = 1.637e-6 Identity = 35/122 (28.69%), Postives = 60/122 (49.18%), Query Frame = 3
Query: 1173 AAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMIN---MSFVGVSGNVTINSNGDRNSEYSLLDMDR---TTGNFSEVS----SYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCK 1508
A +D+ ILYA AV+++ QG + + V + + F G SG V+I+ NG+R +Y++ D+ + TG S ++ I + +++ W PSD P+CG E C+
Sbjct: 2 AYLHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTIN-FTPEYQKMGWP-DGRPPSDMPECGFTGELCQ 121
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 409.068 bits (1050), Expect = 1.607e-124 Identity = 223/517 (43.13%), Postives = 334/517 (64.60%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIE-TTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRK--GQFYLEENENMTTKEKVMKLKYLQ-SYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGE 3476
K++ + +Y+G V+LK ++ + + ++ LL E++ L+++ + ++ F G ++ + +V +YC KGSLKD+L ++ LD MFK S DI GMI++H + I HGNLK + C++DSR +K+TGFG+ + + + V+ Q A L WT+PE LR +GT K DV+SF ++ +E+IY + G + +M KE + +++ + S P RP + T+ C ++ W E+P RPDF +I LR + G +ILDN++S++E+YAN+LE +V +RT Q EK++ + LL S+LP V QL + V E +E VT++F DIVGFT++SA S+P+E++TLLN LY D I++++DVYKVETIGDAY+V SGLP N H EI M++ FL + F I H P QLK+RIG++SG+V AGVVG MPRYCLFGDTVN +SRMES+G PL+IH+S ST +LL + + + ERG +++KGKG QLTYWL+G+
Sbjct: 543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKK-GKIMDVNNQDIAELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYV---GVDMEPKEIIDQVREGKCSPPLRPLL--TERCEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHR-SILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGK 1052 HSP 2 Score: 88.9669 bits (219), Expect = 4.238e-18 Identity = 96/450 (21.33%), Postives = 192/450 (42.67%), Query Frame = 3
Query: 228 PFSKNNLEPVTFMANEYIHANKT-LTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFR-DRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQ---DPYSIYRNVFIVTLKSIVSDDFYNFSNKAKR--IARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAM---INMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSE------VSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPY 1529
PFS L +A + +++N T + NH+ F++ D C+ L SF+ + RE K A++GPVC+ + L W VP++ G G R D + Y+ + G +++ + W + + + +L+++ ++L R + + + +T+ K + +LL+ I ++ E++ A+ G G+++F+ V F ++ F + A+++ V + T+K+ S D+ F + +R + Y+ + V+ + A +D+ ILYA AV+++ G + + + + + F GVSG V I+ NG+R +Y++ ++ + GN S+ ++ G + +++ W + P+D P CG E C+ EIPY
Sbjct: 30 PFSVMRLGAALQIAFDSLNSNPTFMPNHTFAFTYADCACDAKVSLDSFVTQV-RE----------KGIIALLGPVCAEASEVTGLLAAQ-WNVPML--GFVGHTQRMDSSAVYDTYVRIMSPLQRMG-------QMLEATMRHFGWTRAAMLGGTAQNSTWANID--ELWASVERELAR----SVTITARIKYDTSDKVLHRQNLLDISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQFEDS------FWKSVAAERLDTQTLQALEPVMLFTIKAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPYAAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQK-KGNSSQFLPVMVFDTFQGSISFTPEYQKMVWP-EGGPPNDMPICGFLGELCQ---EIPY 441
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 70.0922 bits (170), Expect = 1.355e-12 Identity = 59/247 (23.89%), Postives = 110/247 (44.53%), Query Frame = 3
Query: 1962 VYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTI 2702
++ V+ IKSEK T ++LL E++ K +++ +I +FI D + Y++ E C GSL ++L + +++ + ++ Q IC + Y+H+ H +LK DS + LKI FGL + N+ R+ Y APE L + S + + D++S ++ ++ K F + + + K + + P +DE ++ D +P+ RP I
Sbjct: 106 IFAAKTVAKASIKSEK---TRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNY-----IAPEVLMG--KHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPI----------SDEGKILIRDILSLDPIERPSLTEI 331
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 61.6178 bits (148), Expect = 6.931e-10 Identity = 40/194 (20.62%), Postives = 94/194 (48.45%), Query Frame = 3
Query: 1944 LYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFY 2525
+Y I + +V++K++ E E +++ E+ LK++N+++I ++ G S + Y++ EYC+ GSL+ +++++ L + + G+ Y+H H ++K+ ++ + +K+ FG+ + + L + +L W APE L + + SD++S E++ + ++
Sbjct: 39 VYKAINKHTDQVVAIKEVVYEND-EELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLA--------GTLNWMAPEILGNR----GASTLSDIWSLGATVVEMLTKNPPYH 219
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 60.8474 bits (146), Expect = 9.375e-10 Identity = 51/197 (25.89%), Postives = 99/197 (50.25%), Query Frame = 3
Query: 1971 GTIVSLKQIKSEKRIETTRELLL-EVKKLKDINYHHICRFIGATLDSIDK-YVVYEYCSKGSLKDILAQNEL-------VLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEE 2534
G V++KQ+ K + +EL++ E+ +KD + +I F+ A L + D +VV E+ GSL DI+ + + + Y ++++ C+G+ ++H+ H ++KS ++D+R +KIT FG + R + + V Y W APE ++ ++ K DV+S I+ E++ + + E+
Sbjct: 588 GDKVAIKQMVLSK--QPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAY-IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPY-----WMAPEVVKQR-EYDE---KIDVWSLGIMTIEMLEGEPPYLNED 772
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 58.5362 bits (140), Expect = 5.227e-9 Identity = 57/201 (28.36%), Postives = 92/201 (45.77%), Query Frame = 3
Query: 1989 KQIKSEKRIETTRELLLEVKKLKDINYH-HICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGL-KILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQ 2585
+Q K EK I + + E L I YH HICR S Y+++EY S G L D + Q+ + + + + I +IY+H N H +LK ++ +KI FGL I +L + SL + APE L++N ++ + DV+SF ++ ++ K F E + + K K K++Y Q
Sbjct: 177 RQKKLEKEISRDKRTIREAS-LGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQAR-KFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLH-------TFCGSLYFAAPELLKANP-YTGPEV--DVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQ 365
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 58.151 bits (139), Expect = 5.569e-9 Identity = 64/264 (24.24%), Postives = 112/264 (42.42%), Query Frame = 3
Query: 1926 NINNCKLYGQIA-VYKGT------IVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYS-LIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDR--LRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRP 2687
+I +C G VYK IV++K + E E L E+ L ++ I +I L+ + ++V EYC GS D+L ++ + K S +I ++ G+ Y+H H ++K+ +++ ++K+ FG +SG+ R L+ FV Y W APE + + K+D++S I E++ KG L + + M K + + P R +D V + P +RP
Sbjct: 19 SIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFG---VSGHIRSTLKRDTFVGTPY-----WMAPEVV--CCEVDGYNEKADIWSLGITTYELL--KGLPPLSKYDPM---------KVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRP 261
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9]) HSP 1 Score: 481.1 bits (1237), Expect = 6.494e-158 Identity = 258/524 (49.24%), Postives = 345/524 (65.84%), Query Frame = 3
Query: 1926 NINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLE--ENENMTTKEKVMKLKYLQSYPFRP---TIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
NIN +++ + +YK +V++K+I ++++IE TRE+ E+K ++ + + ++ F GA ++ + ++ +YC KGSL+DIL ++ LD MF SL+ DI +GM Y+H+ I HG LKS CVVD R+VLKIT +GL N + E YY L WTAPE LR+ GT K DVYSF II QE++ R G F L NE EKV ++ +S PFRP TI V + W ENP +RPDF I+ +RKL G NI+DN+++ +E+YANNLE LV ERT Q +EKR+ E LL MLP SVA L+ + V AE+++ V+++FSDIVGFTSLS+ESTP+++V LLN LYT FD I+ +DVYKVETIGDAY+V SGLP N + HA EI MA+ L+E+ +F I HRP+ +LKLRIGIHSG+ AGVVG KMPRYCLFGDTVNT+SRMES+G LKIHIS STK +L + + +RG V +KGKG +TYWL G +
Sbjct: 1 NINQRQIFTTVGIYKSNMVAIKRI-NKRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRKL-WTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYYTNEPSDIIEKVTRV---ESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLP-MGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80]) HSP 1 Score: 473.781 bits (1218), Expect = 1.212e-154 Identity = 244/491 (49.69%), Postives = 336/491 (68.43%), Query Frame = 3
Query: 2004 EKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHN-NIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKL-NRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKEL-FTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWL 3467
++ I+ +R+LLLE+K+++DI + ++ +FIGA + + +V +YCS+GSL+DIL +++ LD +F SL+ DI +GM Y+HN +I HGNLKS+ C+VDSR+VLKIT +GL +L R R E + LLW APE LR ++ GT K DVYSF+II QE R G + E EKV K ++ P+RP + +E ++ W E+P RPDF IK +R++ ++SG NI DN+++ ME YA+NLE LVA+RT+Q ++EKR+ + LL S+LPR VA QL + + V AES+ VT+YFSDIVGFTSLSAESTPM++VT LN LYT FD I++++DVYKVETIGDAY+V SGLP N HA EI KMA+ + + F++ H+P+ +L+LR+G H+G V AGVVG M RYCLFGDTVNT+SRMES+G PL+IHIS TK++L TF++ RG V +KGKG T+WL
Sbjct: 10 KRTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLL----RSRSKKSTIETNWRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYSANYMEPKAIIEKVRKSEF---PPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1]) HSP 1 Score: 392.119 bits (1006), Expect = 4.482e-124 Identity = 209/462 (45.24%), Postives = 294/462 (63.64%), Query Frame = 3
Query: 1968 KGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIH-NNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRS--NTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGL 3344
K +V+LK ++ + + TR++L+E+K+++D+ + ++ +IG + +V +YC +GSL++ILA +E+ LDW F+ S DI GM IH ++I HG+L+S+KC++DSR+V K+ FGL +L N R I V QY + L W APE L++ +T T DVYSF II E++ R+ + E E + +++ + PFRP + K++T W ++P RP F IK LR L G +I+DN+L ME Y LE +V ERT Q +EK + + LLY MLPR +A L R + VIAESY VT++FSDIVGFT L+A STP+++V LLN LYT FD+I+++ DVYKVETIGDAY+V SGLP N + HA EI MA+ L + F H P+R + LRIGIH+G+ AGVVGLKMPRYCLFGDTVN +SRMES+G+
Sbjct: 66 KSYLVALKMLRKDS-LTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQY-SRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTE---FAPIEVIERIRCHLNPPFRPET-PFEIRNRSVTKLMTQCWNDDPQARPTFSDIKRQLRLLK--GGKSSIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO27923 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7T7X3]) HSP 1 Score: 382.104 bits (980), Expect = 1.279e-121 Identity = 199/432 (46.06%), Postives = 274/432 (63.43%), Query Frame = 3
Query: 2160 ILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFS---SGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTI--YATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMK 3437
+L + + LDWMF+ S DI GM IHN+ I HGNLKS+ C++DSR+ KIT +GL +L N ++ + Y +L WT PE L F + T DVYS+ I+ EII R + Y + +++K+ + ++ Q FRP + + + V++ D W + RP F IK L K N G NI+DN+++ M +Y + LE +V ERT+Q EEK + + LLY MLPR +A +L + V AES++ VT++FSDIVGFTS++A+STP+++V LLN+LYT FD ++++ DVYKVETIGDAY+V SGLP N HA E+ MA+ L E+ F IPH P R+++LRIGIHSG+ AGVVGLKMPRYCLFGDTVN +SRMESSGL L+IH+S K +L + + ERG V MK
Sbjct: 2 LLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKD--IGEFAVYRNLFWTVPELLPLADGFKDHKNKTQAGDVYSYGIVLYEIITRD-EPYSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKL-KANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4]) HSP 1 Score: 379.022 bits (972), Expect = 1.117e-119 Identity = 207/485 (42.68%), Postives = 302/485 (62.27%), Query Frame = 3
Query: 2043 VKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFS---SGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTI--YATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
+K ++D+++ ++ R++G ++S + +V +C++G+L+D+L + + LDWMF+ S DI GM IHN+ I HGNLKS+ C++DSR+ KIT +GL +L N ++ + Y +L WTAPE L F + T DVYS+ I+ EII R + Y + +++K+ + ++ Q FRP + + + V++ D W + RP F IK +KL +G + + SR Y NN LV R + KR LL +L R +A +L + +V AES++ VT++FSDIVGFTS++A+STP+++V LLN+LYT FD ++++ DVYKVETIGDAY+V SGLP N HA E+ MA+ L E+ F IPH P R+++LRIGIHSG+ AGVVGLKMPRYCLFGDTVN +SRMESSGL L+IH+S K +L + + ERG V MKGKG +TY+L G++
Sbjct: 1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKD--IGEFAVYKNLFWTAPELLPLADGFKDRKNKTQAGDVYSYGIVLYEIITRD-EPYSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIK---KKLKANGMGNGKISGMFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKD 470
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 592.038 bits (1525), Expect = 0.000e+0 Identity = 392/1038 (37.76%), Postives = 543/1038 (52.31%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK--FIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKI--EMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSI---YRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIY------NASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPS-DTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIIS--SDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDE--QYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
A +GP C Y+ S +R T+ W VP+VT GA GF F +T G ++ E +++ + W + FS N D D R C L L+ + + + + +N + + KN + +C + N LM + G + YVF +DLF P + QD ++ +R+V ++T + +++ F K+ A + +N + N FYD ++LY+RA+ + + K +VT+ M N +F GV G V ++ GDR +++L DM D +G F V YN K K +++ P + P+CG +DN C + + I +++I I + I+R K + EL A W +S + L+ RR + +S+ N Y S + N I Y K Y+ NL V IN +I + + + LK ++ TR FIGA +D + ++ EYC +GSL+D++ + LDWMF+YSLI DI +GM ++HN+ I HGNLKS+ CVVDSRFVLKIT +GL+ LR S D+ YYA LWTAPE LR+ GT K DVYSF II QE+ KG FY+ + + KE + + RP++ ++E ++ WCE P RPDF TIK LRK +R G NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTP+++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H RE+ +MA+A L + +F I HRP +QL+LRIG+HSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S +T+ +L FNTF + RG +E+KGKG TYWL GE+
Sbjct: 107 AFIGPGCDYSSSPVARFTTH-WDVPMVTAGARAD-----------GFSKFAAVTNTGPTHKKLGEFSLKIQETFGWHHHTMLIFSD-NKDDN--DERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQIIQ-------KNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPGGSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMSNLDKVLRRACSRLTISMKGSN-----------------YGSLMTMEGNLQI----YTKTG-----------YYKGNL-------VAIKYINK----KRIELTRNVLFELKHMRDVHNEHLTR-------------------FIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQ------SLRTSSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYI-DTHTLIPKEIIQGVIRGGVPLLRPSL-CFHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGED 1051
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 562.762 bits (1449), Expect = 0.000e+0 Identity = 292/521 (56.05%), Postives = 376/521 (72.17%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDG--CTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENI 3488
+L+ + +KG +V++K + ++KRIE TR++L+E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + LDWMF+YSLI DI +GM ++HN+ G HGNLKS+ CVVDSRFVLKIT +GL R S D+ + YA LWTAPE L + GT K DVYSF II QEI R G FY+E + +++ KE V K++ Q FRPT TD ++E ++ W E+P RPDF IK + KLN+ G T +IL+NLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTP+++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI M++A L+++ TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK +L F F + RG VEMKGKG TYWL GE ++
Sbjct: 492 QLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQKVRNGQRPYFRPT---TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGST-SILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1000 HSP 2 Score: 79.337 bits (194), Expect = 2.131e-14 Identity = 64/229 (27.95%), Postives = 111/229 (48.47%), Query Frame = 3
Query: 1044 NVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK--IYAQVKEIDWGIKDEIPSDTPKC--GSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCL--ETLESRYRRISKKENLS 1709
+VF++T + ++ +F K A+RD+ + + ++ +FYD +LYA A+ + +G N +T N SF GV+G V+I+ RN + L M ++ TG + VS YNG TK +++Q ++I W P D P C +D+ C + + G +A+I+ I +I+R K + EL M W + + L E+ ++R + LS
Sbjct: 249 SVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP-PLDNPPCVFSTDDPSCNDGLPV-LGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSRLTLS 475
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 562.762 bits (1449), Expect = 0.000e+0 Identity = 292/521 (56.05%), Postives = 376/521 (72.17%), Query Frame = 3
Query: 1941 KLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQY--YASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDG--CTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENI 3488
+L+ + +KG +V++K + ++KRIE TR++L+E+K ++D+ ++H+ RFIGA +D + +V EYC +GSL+DIL + LDWMF+YSLI DI +GM ++HN+ G HGNLKS+ CVVDSRFVLKIT +GL R S D+ + YA LWTAPE L + GT K DVYSF II QEI R G FY+E + +++ KE V K++ Q FRPT TD ++E ++ W E+P RPDF IK + KLN+ G T +IL+NLLSRMEQYANNLE LV ERT+ YLEEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFTS+SAESTP+++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N HAREI M++A L+++ TF I HRP+ QL+LRIGIH+G VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+SS+TK +L F F + RG VEMKGKG TYWL GE ++
Sbjct: 544 QLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLA------SFRSSCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQKVRNGQRPYFRPT---TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGST-SILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1052 HSP 2 Score: 110.923 bits (276), Expect = 4.398e-24 Identity = 118/512 (23.05%), Postives = 217/512 (42.38%), Query Frame = 3
Query: 219 RRFPFSKNNLEPVTFMANEYIHA-NKTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESK------QISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYK-NYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITK--IYAQVKEIDWGIKDEIPSDTPKC--GSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCL--ETLESRYRRISKKENLS 1709
++P++ + P MA E +H +K L H++ + L+ E A S C+++ ++ ++ R GP C Y ++ R ++ WK+P++T G F + EY K I G + + ++NW + + +D D R S + +++ R NE K +L++ K N I IC F+ +M + + Y +D+F + P+ +P ++++VF++T + ++ +F K A+RD+ + + ++ +FYD +LYA A+ + +G N +T N SF GV+G V+I+ RN + L M ++ TG + VS YNG TK +++Q ++I W P D P C +D+ C + + G +A+I+ I +I+R K + EL M W + + L E+ ++R + LS
Sbjct: 45 HKYPWALPRVFPALLMAQEDLHTKHKLLLGHTI--TILNYSTENPAAPGS--------CAESRAQVVVVDAKLYSRPDVFFGPGCVYPLASVGRFVSH-WKLPLITAGGPAYGFEKLD-EY-------KTIVRIGPSTTKLGAFVNVLHTQFNWTSR---AVVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYK-----ELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQDPESYAIFYLDVFAESLTHRKPWQNAKFDWTNPIQVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP-PLDNPPCVFSTDDPSCNDGLPV-LGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSRLTLS 527
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799]) HSP 1 Score: 557.37 bits (1435), Expect = 1.674e-179 Identity = 285/521 (54.70%), Postives = 371/521 (71.21%), Query Frame = 3
Query: 1932 NNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQ-YYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYP-FRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENEN 3485
N +++ + YKG IV++K ++KRIE R++L E+K ++D+ H+ RFIGA +D + ++ EYC +GSL+DIL + + L+WMFK+SLI DI +GM+++HN+ I HG LKS+ CVVD+RFVLKIT +GL R + D YYA LW APE LR GT K DVYSF+II QE+ R+G FYL+ + ++ KE V ++ L +P RP+I + E +++ W E P RPDF I+ LRK N+ T NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ V++YFSDIVGFT+LSAESTPME+VTLLN LYT FD++++ FDVYKVETIGDAY+V SGLP N H REI +MA+A L + TF I HRP++QLKLRIGIHSG VCAGVVGLKMPRYCLFGDTVNTSSRMESSG LKIH+S++T+++L FN+F + RG +++KGKG TYWL GE+++
Sbjct: 551 GNLQVFAKTGYYKGNIVAIK-YTNKKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTF----RQESDVGSDSHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLD-GDPLSPKEIVDRV-ILGDWPCLRPSI-DPQSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESDS 1062 HSP 2 Score: 113.235 bits (282), Expect = 8.112e-25 Identity = 119/509 (23.38%), Postives = 222/509 (43.61%), Query Frame = 3
Query: 180 KEIINIYVVTP-YDRRFPFSKNNLEPVTFMANEYIHANKTL-TNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISK--RFA----AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERK-VKIEMLRKKLNETAIKSSFKSDLLNEYKNYS-IFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDM-DRTTGNFSEVSSYNGITKIYAQVK--EIDWGIKDEIPSDTPKCG--SDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLE 1661
++ I + ++ P + +P++ + P A I+++ L NH L + F S + ++ CS++ + ++ FA A +GP CSYT S T+ W VP++T GA F D G + IT G ++ + + + W++++ TL D D R C A++ L E K + I + E ++ S +L + +N + +C +P F LM + + +YVF+ +DLF + + P+ + +++V I++ + + ++ F K A+ +N S +N FYD ++LYA A+ + + +++ M N +F GV+G + ++ +GDR ++++L D+ D + +F V YN + V + W + P D PKCG +DN C K + + + + + I + I R K + EL A W IS D ++
Sbjct: 42 RQNITLAIILPETNTAYPWAWPRIGPALERAIIKINSDPNLLPNHHLTYVFKSS------------ENSNGICSESVAPLVAVDLEFAYKPWAFIGPGCSYTASPVGLFTTH-WDVPLITAGAPAIAFLD-------GI--YPTITNTGPTHKKLGRFALRICEHFGWREYV---TLMFSDNKEDDRPCYF---AMEGLYEELKSINISLQDSVFEENKPPINY-SQILADIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPWARGDQDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRW-LGGARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQ 520
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 553.903 bits (1426), Expect = 4.770e-179 Identity = 285/519 (54.91%), Postives = 366/519 (70.52%), Query Frame = 3
Query: 1932 NNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNN-IGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDE--QYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGEN 3479
N ++Y + YKG +V++K I ++KRIE TR +L E+K ++D++ H+ RFIGA +D + ++ EYC +GSL+D++ + LDWMF+YSLI DI +GM ++HN+ I HGNLKS+ CVVDSRFVLKIT +GL+ LR S D+ YYA LWTAPE LR+ GT K DVYSF II QE+ KG FY++ + KE + + RP++ ++E ++ WCE P RPDF TIK LRK +R G NILDNLLSRMEQYANNLE LV ERT+ Y EEKR+AE LLY +LP SVA QL R + V AE+++ VT+YFSDIVGFT+LSAESTP+++VTLLN LYT FD+I++ FDVYKVETIGDAY+V SGLP N H RE+ +MA+A L + +F I HRP +QL+LRIG+HSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S +T+ +L FNTF + RG +E+KGKG TYWL GE+
Sbjct: 484 GNLQIYTKTGYYKGNLVAIKYI-NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQ------SLRTSSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYID-THTLIPKEIIQGVIRGGVPLLRPSL-CFHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGED 992
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000007014.1 (SMESG000007014.1) HSP 1 Score: 2292.69 bits (5940), Expect = 0.000e+0 Identity = 1142/1143 (99.91%), Postives = 1142/1143 (99.91%), Query Frame = 3
Query: 114 MDNRYWIVSIYFFVVLDEIIASKEIINIYVVTPYDRRFPFSKNNLEPVTFMANEYIHANKTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVIISNLHVPS 3542
MDNRYWIVSIYFFVVLDEIIASKEIINIYVVTPYDRRFPFSKNNLEPVTFMANEYIHANKTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFY FSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFIVGGISIAIILVIIICVVIFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNKDDRKLKKKKSKITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVIISNLHVPS
Sbjct: 1 MDNRYWIVSIYFFVVLDEIIASKEIINIYVVTPYDRRFPFSKNNLEPVTFMANEYIHANKTLTNHSLQFSFLDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQLIRERKVKIEMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYSIYRNVFIVTLKSIVSDDFYKFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKEIDWGIKDEIPSDTPKCGSDNERCKPKYEIPYYFIVGGISIAIILVIIICVVIFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNKDDRKLKKKKSKITRSQYSSKEILFENFGINKFLYDKISCPLSQNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVIISNLHVPS 1143
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1) HSP 1 Score: 942.954 bits (2436), Expect = 0.000e+0 Identity = 523/1096 (47.72%), Postives = 712/1096 (64.96%), Query Frame = 3
Query: 327 LDSDCEPTAVLSSFLQKTHRECSKNESKQISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFR-DRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQK--FIYF-----STLNLFDYYYDFRYCQLFSTAL----QQLIRERKVKIEMLRKKLNETAIK--SSFKSDLLNEYKNY-SIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLL---TNASKQDPYSIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVKE--IDWG-IKDEIPSDTPKCGSDNERC-KPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENL---SVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLS-----------QNHHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDRLRESIFVDE--QYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSYPFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPL 3500
+DSDC +TH+ ++ + + I GP+C Y I+ +RL W P++T GA F DR E FH + +G+ + LI E+F KY W K +I+F ST+ + YC L +++++ +K+ +L+ IK S+ + L+ + N +I ++C P ++M A F NGEY+F+N+D+F++ + + P+ N + +R + +TL+ + + FS + KR A+ +YN + + E VNSFV++F+D++ILYA + +G I + +V + M N SF + VTI+ +GDR +++SL+D+++ TG F VS+Y G + Y V + IDWG + ++IP DTP CG D C KP Y I G + + + II V I R KFQAEL AM+WII D LET E R R+ S +N + + K + + +T+ E + EN+ +L I ++ D S SN S+D+I G+ +++ +L+ + A++KG +V+LK I +IE T ELL+E+KK+KD++ HICRFIG LD Y+VYEYC KGSL+D+LA+ ++ LDWMFKYSL+QDICRGMIY+HNN GPHGNLKS+ C+VDSRFVLKIT FGL L GN + ++ +E YY S LWTAPE L + +GTIK DVYSFA+ICQEI+YR G F L + N+T+KE K++ S PFRPT+ TDGCTD+ +K++ AW E+P +RPDF TIK +RKLN+ GDTGNILDNLLSRMEQYANNLEGLVA+RTEQYLEEK++AE LLYSMLP+ VAHQLI+ QNVIAESY+MVT++FSDIVGFT+LSAESTPM+I+ LLN+LYTTFDSI+E +DVYKVETIGDAY+VCSGLP+ N N H+REI +M+IAFL+ + F+IPHRPD++L+LRIGIHSG VC+GVVGLKMPRYCLFGDTVNTSSRMES+GLPLKIHIS STK +L TF TFI++ERG++++KGKGLQLTYWLHGE+ NIVDPL
Sbjct: 95 IDSDC----------LQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMA-FWNRPVITTGALYYAFSSDRIAE----FHTLTRV-GSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPM--------YCHGLGIYLVKGARKIVKNWPIKV---YTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGA-ISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESI-ENY----YLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLDH--PYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGN---KTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPL 1152
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 932.554 bits (2409), Expect = 0.000e+0 Identity = 513/1067 (48.08%), Postives = 695/1067 (65.14%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFR-DRNVEYERGFHGFKFITAAGYHYQDP--AELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQ---------LIRERKVKIEMLRKKL-NETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS----IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVK--EIDWG-IKDEIPSDTPKCGSDNERC-KPKYEIPY-YFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRIS----KKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNH--------HDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDR--LRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY-PFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVII 3521
+ GP+C Y ++ +RL W +PI++ GA FR +R E FK +T G + D ++I + F KY W IY + YC L Q IR+ K E+ L N+TA++ + N+Y ++ V+C P++ ++ A + FNNGEYVFIN+ LF++ P+ LT AS Q S YR++ VTLK ++ F NFS++ K +A R+YN Y+ + +N+FV+ FYD ++LYA A+ K G I N S++ + M N +F G+ G VTI+S+GDR +++S+LDMD TG F V+ + G + V +DWG + + IPS P+CG DN C KP + G + ++ ++RN K QAEL AM+WII + LET E ++ K ++ + + + + + K TR++ + +L E +K S +S+N+ + + S S+++IAG+ I N +L+ + A+YKG +V+LK I S++RI+ R+LL++VKK+KD+N HICRFIGA L+ +Y+VY+YC KGSL+D+LA+ ++ LDW+FKYSLIQDICRGM+Y+HNN+GP G LKS+ C+VDSRFVLKIT FGL L G+ + L E V Y+ +LLWTAPE LR + GT K DVYSFAI+CQEI+YRKG F L+ ++ + +E V +K S PFRP++ A GCT++FV ++ +W E+P+ RPDF TIK +RK N+ GD+GNILDNLLSRMEQYANNLE +V ERTEQYLEEK++AE LLYSMLP+SVAHQLI+ Q V AESY++VT++FSDIVGFT+LSAESTPM+I+ LLN+LYTTFDSI+E +DVYKVETIGDAY+VCSGLP+ N N HAREI +MAIAFL +F FVIPHRPD++LKLRIGIHSG VC+GVVGLKMPRYCLFGDTVNTSSRMES+GLP KIHIS ST LL TF TF+MTERG++E+KGKG TYWLHGENE IVDP+ P D +
Sbjct: 108 VLFGPICGYVLAPIARL-LAFWNIPILSTGAVYYGFRKERKSE-------FKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPL-YCHALGGYLTQEFEITVDYWPIRQYK---ELTTATLTNDTALEQFLIDAIGNKY---AVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLT-ASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNVKGTRNEMENLHLLHE--------VEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNV---YFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPV-PKDAFL 1146
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 931.013 bits (2405), Expect = 0.000e+0 Identity = 515/1063 (48.45%), Postives = 687/1063 (64.63%), Query Frame = 3
Query: 432 AIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFR-DRNVEYERGFHGFKFITAAGYHYQDP--AELIIEMFIKYNWQKFIYFSTLNLFDYYYDFRYCQLFSTALQQ---------LIRERKVKIEMLRKKL-NETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPYS----IYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVK--EIDWG-IKDEIPSDTPKCGSDNERC-KPKYEIPY-YFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRISKKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQNH--------HDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSGNDR--LRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENENMTTKEKVMKLKYLQSY-PFRPTIYATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVII 3521
+ GP+C Y ++ +RL W +PI++ GA FR +R E FK +T G + D ++I + F KY W IY + YC L Q IR+ K E+ L N+TA++ + N+Y ++ V+C P++ ++ A + FNNGEYVFIN+ LF++ P+ LT AS Q S YR++ VTLK ++ F NFS++ K +A R+YN Y+ + +N+FV+ FYD ++LYA A+ K G I N S++ + M N +F G+ G VTI+S+GDR +++S+LDMD TG F V+ + G + V +DWG + + IPS P+CG DN C KP + G + ++ ++RN K QAEL AM+WII + LET E +I N + K K +RSQ L +K S +S+N+ + + S S+++IAG+ I N +L+ + A+YKG +V+LK I S++RI+ R+LL++VKK+KD+N HICRFIGA L+ +Y+VY+YC KGSL+D+LA+ ++ LDW+FKYSLIQDICRGM+Y+HNN+GP G LKS+ C+VDSRFVLKIT FGL L G+ + L E V Y+ +LLWTAPE LR + GT K DVYSFAI+CQEI+YRKG F L+ ++ + +E V +K S PFRP++ A GCT++FV ++ +W E+P+ RPDF TIK +RK N+ GD+GNILDNLLSRMEQYANNLE +V ERTEQYLEEK++AE LLYSMLP+SVAHQLI+ Q V AESY++VT++FSDIVGFT+LSAESTPM+I+ LLN+LYTTFDSI+E +DVYKVETIGDAY+VCSGLP+ N N HAREI +MAIAFL +F FVIPHRPD++LKLRIGIHSG VC+GVVGLKMPRYCLFGDTVNTSSRMES+GLP KIHIS ST LL TF TF+MTERG++E+KGKG TYWLHGENE IVDP+ P D +
Sbjct: 108 VLFGPICGYVLAPIARL-LAFWNIPILSTGAVYYGFRKERKSE-------FKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPL-YCHALGGYLTQEFEITVDYWPIRQYK---ELTTATLTNDTALEQFLIDAIGNKY---AVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLT-ASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSE----KIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNMENLHLLHEV-------EKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNV---YFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPV-PKDAFL 1139
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000039747.1 (SMESG000039747.1) HSP 1 Score: 883.248 bits (2281), Expect = 0.000e+0 Identity = 487/1054 (46.20%), Postives = 681/1054 (64.61%), Query Frame = 3
Query: 411 QISKRFAAIMGPVCSYTISIFSRLNTNLWKVPIVTVGAFGQPFRDRNVEYERGFHGFKFITAAGYHYQDPAELIIEMFIKYNWQKFIYFST-LNLFDYYYDFRYCQLFSTALQQLIRERKVKI--EMLRKKLNETAIKSSFKSDLLNEYKNYSIFVICTAPSNFIELMDTAKETGFNNGEYVFINVDLFNNAENLINPFLLTNASKQDPY--SIYRNVFIVTLKSIVSDDFYNFSNKAKRIARRDYNTSYDGEHVNSFVAAFYDSIILYARAVQKVFIQGKDIYNASIVTEAMINMSFVGVSGNVTINSNGDRNSEYSLLDMDRTTGNFSEVSSYNGITKIYAQVK--EIDW-GIKDEIPSDTPKCGSDNERCKPKYEIPYYFXXXXXXXXXXXXXXXXXXXFRNAKFQAELKAMSWIISSDCLETLESRYRRIS-KKENLSVGSMNXXXXXXXXXXXXITRSQYSSKEILFENFGINKFLYDKISCPLSQN----HHDSVSYQSNLSIDSIAGVQFSNINNCKLYGQIAVYKGTIVSLKQIKSEKRIETTRELLLEVKKLKDINYHHICRFIGATLDSIDKYVVYEYCSKGSLKDILAQNELVLDWMFKYSLIQDICRGMIYIHNNIGPHGNLKSTKCVVDSRFVLKITGFGLKILSG--NDRLRESIFVDEQYYASLLWTAPERLRSNTQFSSGTIKSDVYSFAIICQEIIYRKGQFYLEENEN-MTTKEKVMKLKYLQSYPFRPTI-YATDGCTDEFVKIVTDAWCENPLNRPDFPTIKSALRKLNRSGDTGNILDNLLSRMEQYANNLEGLVAERTEQYLEEKRRAETLLYSMLPRSVAHQLIRKQNVIAESYEMVTVYFSDIVGFTSLSAESTPMEIVTLLNKLYTTFDSILEQFDVYKVETIGDAYVVCSGLPKPNENNHAREIGKMAIAFLKELFTFVIPHRPDRQLKLRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWLHGENENIVDPLNPGDVII 3521
Q S R I+GP+ + I+ RL+ ++VP++T G R + F+ +T+ + +QD +++ MF ++ W+ Y + L +FD D S + + +++ KI E+ ++KL TA + K +L KN I ++C P ++M A + GF+ G+Y FI+ D+ N +++ + N+++++ YR++ I+TL S++F +FS + K+ ++ S + V+ FV AF+DS+++YA A+ K++ + +TE M N S G+SGNV I+SNGDRN++YSLLDMD T F V+ NG K ++ V +IDW + + P DTPKCG N C + + + + +I+ ++ +VI+R+ KF ELKAM+W+I DC+ET E R R S K L ++NK ++ + +S ++ E EN +L L Q + +S S S++++AG+QF N+ N +++ + VYK IV++K I K+IE + LL++VKK+KD+N HICRFIGA L+ ++ EYC KGSL+D+L +++ LDW+FK+SLIQDICRGMIY+H+NIGPHGNLKS+ C++DSRFV+K+T FGL+ L G + L E+ + +Y +LLWTAPE LR++ GT+K D+YSFAII QEIIYR G FYL E E + +E V ++K + PFRP + ++ E I+ W E PL RP+ IK RK N++GD+GNILDNLLSRMEQYANNLEGLV +RTEQYLEEKR+AE LLY MLP+SVA QLIR + V AESYE VT+YFSDIVGFTSLSAESTPM+++ LLN LYTTFDSILE +DVYKVETIGDAYVV SGLP+ N N HAREI +M++AFL+ LFTF IPHR DRQL +RIG+HSG VCAGVVGLKMPRYCLFGDTVNT+SRMES+G +KIHIS +T ++L TF +FI+TERG +E+KGKG Q TYWLHGE E+IVDP+ P +I
Sbjct: 71 QNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKK--------QDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKL--TARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTL---STILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKS-FAENEFNMEN----HYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYA---FYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFTFQIPHRQDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVI 1096 The following BLAST results are available for this feature:
BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014646 ID=SMED30014646|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3595bpback to top protein sequence of SMED30014646-orf-1 >SMED30014646-orf-1 ID=SMED30014646-orf-1|Name=SMED30014646-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1144bp MDNRYWIVSIYFFVVLDEIIASKEIINIYVVTPYDRRFPFSKNNLEPVTFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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