DNA mismatch repair protein PMS2

Overview
NameDNA mismatch repair protein PMS2
Smed IDSMED30014562
Length (bp)4559
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA mismatch repair protein PMS2 (SMED30014562) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA mismatch repair protein PMS2 (SMED30014562) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA mismatch repair protein PMS2 (SMED30014562) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA mismatch repair protein PMS2 (SMED30014562) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30014562

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30014562h1SMcG0000647 SmedASXL_015095SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
muscle cellSMED30014562h1SMcG0000647 dd_Smed_v4_16760_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30014562h1SMcG0000647 dd_Smed_v4_16760_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Match: PMS2 (PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122])

HSP 1 Score: 251.906 bits (642), Expect = 7.987e-69
Identity = 135/350 (38.57%), Postives = 209/350 (59.71%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ ++  +ICS Q V+S++ A+KEL+ENSLDA +  I+++LK++G D+IEV DNG G+    F+  T ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I    +   +  + +E+ +S    L  +  +SG+ISQ T     S++ +QF ++NRRPC+  KV RL+ E Y + N+   P  V++IS+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:   15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV-QLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 363          

HSP 2 Score: 176.022 bits (445), Expect = 4.251e-44
Identity = 89/240 (37.08%), Postives = 140/240 (58.33%), Query Frame = 2
Query: 1253 ISANFSM----KYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  +FSM    K I  L   A+         K++++I    N+ AE+EL++   K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  616 VPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 853          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Match: PMS2 (PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122])

HSP 1 Score: 176.407 bits (446), Expect = 1.406e-46
Identity = 92/226 (40.71%), Postives = 137/226 (60.62%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMI 625
            IK I+ ++  +ICS Q V+S++ A+KEL+ENSLDA +  I+++LK++G D+IEV DNG G+    F+  T ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I
Sbjct:   15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI 240          

HSP 2 Score: 163.696 bits (413), Expect = 2.631e-42
Identity = 77/197 (39.09%), Postives = 120/197 (60.91%), Query Frame = 2
Query: 1370 TAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  + L  +F K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  258 SCSDALHNLFYKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 452          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Match: PMS2 (PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122])

HSP 1 Score: 175.637 bits (444), Expect = 1.639e-44
Identity = 89/240 (37.08%), Postives = 140/240 (58.33%), Query Frame = 2
Query: 1253 ISANFSM----KYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  +FSM    K I  L   A+         K++++I    N+ AE+EL++   K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  481 VPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 718          

HSP 2 Score: 158.303 bits (399), Expect = 6.027e-39
Identity = 84/228 (36.84%), Postives = 137/228 (60.09%), Query Frame = 2
Query:  320 FGFRGEALNSLCFLGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            F   G+ +    +   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I    +   +  + +E+ +S    L  +  +SG+ISQ T     S++ +QF ++NRRPC+  KV RL+ E Y + N+   P  V++IS+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:    2 FDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV-QLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 228          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Match: PMS2 (PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122])

HSP 1 Score: 175.637 bits (444), Expect = 1.639e-44
Identity = 89/240 (37.08%), Postives = 140/240 (58.33%), Query Frame = 2
Query: 1253 ISANFSM----KYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  +FSM    K I  L   A+         K++++I    N+ AE+EL++   K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  481 VPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 718          

HSP 2 Score: 158.303 bits (399), Expect = 6.027e-39
Identity = 84/228 (36.84%), Postives = 137/228 (60.09%), Query Frame = 2
Query:  320 FGFRGEALNSLCFLGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            F   G+ +    +   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I    +   +  + +E+ +S    L  +  +SG+ISQ T     S++ +QF ++NRRPC+  KV RL+ E Y + N+   P  V++IS+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:    2 FDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV-QLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 228          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Match: PMS2 (PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122])

HSP 1 Score: 175.637 bits (444), Expect = 2.085e-44
Identity = 89/240 (37.08%), Postives = 140/240 (58.33%), Query Frame = 2
Query: 1253 ISANFSM----KYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  +FSM    K I  L   A+         K++++I    N+ AE+EL++   K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  510 VPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 747          

HSP 2 Score: 158.303 bits (399), Expect = 7.315e-39
Identity = 84/228 (36.84%), Postives = 137/228 (60.09%), Query Frame = 2
Query:  320 FGFRGEALNSLCFLGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            F   G+ +    +   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I    +   +  + +E+ +S    L  +  +SG+ISQ T     S++ +QF ++NRRPC+  KV RL+ E Y + N+   P  V++IS+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:   31 FDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV-QLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 257          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Celegans
Match: pms-2 (PMS (Post Meiotic Segregation) family [Source:UniProtKB/TrEMBL;Acc:G5EFG5])

HSP 1 Score: 203.756 bits (517), Expect = 8.784e-54
Identity = 120/369 (32.52%), Postives = 196/369 (53.12%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKI--DKNKQVILSTRGIGGISENIKSVFG------------------QNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLK 1000
            I+RI+ + ++R+ ++Q VVS+++AI++LI+NS+DA S  I+IR+KN G + IEV DNG+GI    FD     ++TSKL  F D + L T GFRGEALN+LC +                                  + GTT+ +  +F TLPVRRK+   + KREF K L+ + S+ L+C  ++I C      K   +I +  G   I + + ++FG                  QNQ +  +E+ T H++  + +  F++ K+         G++S          S +QF+Y+N RP E  +V  +I + Y+  NK   P  V+ I +P E +DVN+ PDK+ ++L+ +  + AV++AS++  +LK
Sbjct:    6 IERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIIDIRVKNNGFESIEVQDNGSGIEARNFDALCKPHSTSKLTQFSDFDKLATLGFRGEALNALCTVSSVSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGTTIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSFALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQNQPD--VEIMTIHSVPMEEMHFFDLFKI--------RGFVSSCEHGCGRGTSDRQFVYINNRPVEYSRVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDVNVTPDKKTVMLEKERHLLAVVRASMMKTYLK 364          

HSP 2 Score: 182.185 bits (461), Expect = 9.032e-47
Identity = 92/224 (41.07%), Postives = 131/224 (58.48%), Query Frame = 2
Query: 1292 DTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCL 1963
            + +AE D+ N    K    I+   N  AE +L R   K  F+ +++IGQFN GFII RL   LFI+DQHASDEK  FE+  +  +++ QPL  P  L   +  E II EN+ +F+  GF F+F E +   + F+TA P   N  L   DL E+L ++  Y +  +  P+R+R   AS ACR ++MIG  L+  +M +I++ ++ L  PW C HGRPTIRHL  L
Sbjct:  580 EVSAEKDVLNEITTK----INKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFIICRLRGHLFIVDQHASDEKYNFERLQSSAKLTKQPLFMPTALGFGAVQELIIRENLPIFHANGFDFEFSENDGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQ-MYRPVRIRKIFASKACRKSVMIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASL 798          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Celegans
Match: mlh-1 (MLH (MutL Homolog) family [Source:UniProtKB/TrEMBL;Acc:Q9XU10])

HSP 1 Score: 91.6633 bits (226), Expect = 2.232e-18
Identity = 79/331 (23.87%), Postives = 149/331 (45.02%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC---------------------FL------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQP-----TEVFKSSNSSKQF--LYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDK 925
            I+R+      R+ + + +     AIKEL+ENSLDA + +I + ++N G  +++V DNG GI   +F     R  TSKL+ F+DL +++T+GFRGEAL SL                      FL            G+ GT ++  ++F+ LP RR + +     E     + +  + +    V  +   + +N+     T+G G   + + ++ G++  + ++ L+             N +++    K   +G IS+P       + ++  +S+ F  +++N R      +K  I E      + H     + + + +  +DVN+ P K
Sbjct:    4 IQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNGKGIEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCAYQANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRRNK-MTTHGEEAKMVNDTLLRFAIHRPDVSFA---LRQNQAGDFRTKGDGNFRDVVCNLLGRDVADTILPLS------------LNSTRL----KFTFTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDILKHPIDEVLGA-RQLHAQFCALHLQIDETRIDVNVHPTK 313          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Fly
Match: Pms2 (gene:FBgn0011660 transcript:FBtr0087388)

HSP 1 Score: 197.978 bits (502), Expect = 2.052e-51
Identity = 121/354 (34.18%), Postives = 179/354 (50.56%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL--------------GQK-------------------GTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKN--KQVILSTRGIGGISENIKSVFGQNQLNGMIELT--------TEHNINQDILDEFNISKVA------------NLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQ 949
            IK I   T  +ICS Q V+S+A A+KEL+ENS+DA +  +EI+LK+ G   +EV DNG+G+     +  T++  TSK+  F DL  +ETFGFRGEAL+SLC L              G K                   GTTV + N+F TLPVRR+ F  N+K+EF K    + +YCL+ +GV+I C        K ++L T G   +  NI ++FG  Q   ++ L         TE  +  D+    +++               N    +L G+IS        S+  +QF +VN RPC+   + +++ E Y   N    P   ++I   +  VDVN+ PDKR LL++N+
Sbjct:   27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNE 380          

HSP 2 Score: 183.726 bits (465), Expect = 7.268e-47
Identity = 87/209 (41.63%), Postives = 132/209 (63.16%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSY-VQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            ++K+EI+ N N +AE EL+R   K+ F  +E+IGQFN GFII +L  DLFI+DQHA+DEK  FE      ++  Q LA P+ L++++ +E ++  +ID+F K GF+F+   EA    ++ +   P       G ED+ E++ +++D     I  P RVR+  AS ACR ++MIGT+LS    M +++ QM  ++ PW C HGRPT+RHL
Sbjct:  672 RFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHL 880          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Fly
Match: Mlh1 (gene:FBgn0011659 transcript:FBtr0088790)

HSP 1 Score: 122.094 bits (305), Expect = 6.598e-28
Identity = 96/357 (26.89%), Postives = 165/357 (46.22%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRV-MNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEY 1021
            I++++     RI + + +   A A+KEL+ENSLDA S  I++++K  G  ++++ DNGTGI   +      R TTSKL  F+DL+ + TFGFRGEAL S+  +                                 G +GT + I ++F+ +P RR Q L +   EF +    +  Y +    V  +  K   + Q  L T      SENI+ ++G               I++++L+    S    + K E    I+Q   V  S+   +  L++N+R  E   ++  +   Y   + + H+P   +S++LP + +DVN+ P K  +    Q E+   IK  + +  L S  ++ +
Sbjct:   10 IRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRR-QALRSPAEEFQRLSEVLARYAVHNPRVGFTLRK-QGDAQPALRTPVASSRSENIRIIYGA-------------AISKELLE---FSHRDEVYKFEAECLITQ---VNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTF 345          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Fly
Match: Mlh1 (gene:FBgn0011659 transcript:FBtr0331379)

HSP 1 Score: 120.168 bits (300), Expect = 3.156e-27
Identity = 95/356 (26.69%), Postives = 164/356 (46.07%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEY 1021
            I++++     RI + + +   A A+KEL+ENSLDA S  I++++K  G  ++++ DNGTGI   +      R TTSKL  F+DL+ + TFGFRGEAL S+  +                                 G +GT + I ++F+ +P RR Q L +   EF +    +  Y +    V  +  K   + Q  L T      SENI+ ++G               I++++L+    S    + K E    I+Q   V  S+   +  L++N+R  E   +  + +     + + H+P   +S++LP + +DVN+ P K  +    Q E+   IK  + +  L S  ++ +
Sbjct:   10 IRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRR-QALRSPAEEFQRLSEVLARYAVHNPRVGFTLRK-QGDAQPALRTPVASSRSENIRIIYGA-------------AISKELLE---FSHRDEVYKFEAECLITQ---VNYSAKKCQMLLFINQRLVESTGLTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTF 344          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Match: pms2 (PMS1 homolog 2, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030131-686])

HSP 1 Score: 232.261 bits (591), Expect = 6.064e-64
Identity = 122/350 (34.86%), Postives = 207/350 (59.14%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ Q+  +ICS Q V+S+A A+KEL+ENS+DA +  ++++LK+ G +++EV DNG G+    ++  T ++ TSKL+ F DL ++ETFGFRGEAL+SLC L                                  Q GTTV+++ +F TLPVR K+F  N+K+E+ K +  + SYC+I  GV+I+C  ++ + K+  +L T G   + +NI +VFG  QL  +I    + + N  + +++ +  V   + +  + G++SQ       S + +QF ++N+RPC+  KV +L+ E Y + N+   P   ++I++  + VDVN+ PDKR +LL  +  + A++K+S+++ F
Sbjct:   30 IKAIDKQSVHQICSGQVVLSLATAVKELVENSIDAGATNVDVKLKDNGIELVEVSDNGKGVEEQNYEGLTLKHHTSKLKEFSDLIHVETFGFRGEALSSLCALSDLSVVTCHESAQIGARLVYDHDGRLTQCVPHPRQHGTTVTLQKLFSTLPVRHKEFQRNIKKEYSKMIFVLQSYCIISTGVRITCSNQMGQGKRSTVLCTSGSNSMRDNIGAVFGPKQLQSLIPFR-QISPNDSVKEDYGLGGVDVPKDLFNIDGFVSQGDHGVGRSATDRQFFFINKRPCDPVKVSKLVNEVYHMYNRHQYPFVALNIAVASDCVDVNVTPDKRQILLQEEKLLLAILKSSLIAMF 378          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Match: pms2 (PMS1 homolog 2, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030131-686])

HSP 1 Score: 231.491 bits (589), Expect = 2.058e-62
Identity = 122/350 (34.86%), Postives = 207/350 (59.14%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ Q+  +ICS Q V+S+A A+KEL+ENS+DA +  ++++LK+ G +++EV DNG G+    ++  T ++ TSKL+ F DL ++ETFGFRGEAL+SLC L                                  Q GTTV+++ +F TLPVR K+F  N+K+E+ K +  + SYC+I  GV+I+C  ++ + K+  +L T G   + +NI +VFG  QL  +I    + + N  + +++ +  V   + +  + G++SQ       S + +QF ++N+RPC+  KV +L+ E Y + N+   P   ++I++  + VDVN+ PDKR +LL  +  + A++K+S+++ F
Sbjct:   12 IKAIDKQSVHQICSGQVVLSLATAVKELVENSIDAGATNVDVKLKDNGIELVEVSDNGKGVEEQNYEGLTLKHHTSKLKEFSDLIHVETFGFRGEALSSLCALSDLSVVTCHESAQIGARLVYDHDGRLTQCVPHPRQHGTTVTLQKLFSTLPVRHKEFQRNIKKEYSKMIFVLQSYCIISTGVRITCSNQMGQGKRSTVLCTSGSNSMRDNIGAVFGPKQLQSLIPFR-QISPNDSVKEDYGLGGVDVPKDLFNIDGFVSQGDHGVGRSATDRQFFFINKRPCDPVKVSKLVNEVYHMYNRHQYPFVALNIAVASDCVDVNVTPDKRQILLQEEKLLLAILKSSLIAMF 360          

HSP 2 Score: 176.407 bits (446), Expect = 1.664e-44
Identity = 84/209 (40.19%), Postives = 130/209 (62.20%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+   N+TAE+ELK+   K  F ++E+IGQFN GFII ++  DLFIIDQHA+DEK  FE       +  Q L  P+ L + +  E ++ EN+++F K GF F   E A++  R+ + ++P   N   G  D+ E++ ++ D  G  C   P RVR   AS ACR ++M+GT+L+  +M K++  M  ++ PW C HGRPT+RHL
Sbjct:  636 RFRAKINPGENQTAEDELKKEISKDMFKEMEIIGQFNLGFIITKIKSDLFIIDQHATDEKYNFEMLQQNTVLKGQRLIVPQSLHLPAISETVLMENLEIFRKNGFDFLIDEDAQVMDRVKLVSLPTSKNWTFGPNDIEELIFMLSDSPGIMC--RPSRVRQMFASRACRKSVMVGTALNTSEMKKLVLHMGEIEQPWNCPHGRPTMRHL 842          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Match: pms2 (PMS1 homolog 2, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030131-686])

HSP 1 Score: 166.392 bits (420), Expect = 2.322e-43
Identity = 88/226 (38.94%), Postives = 136/226 (60.18%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMI 625
            IK I+ Q+  +ICS Q V+S+A A+KEL+ENS+DA +  ++++LK+ G +++EV DNG G+    ++  T ++ TSKL+ F DL ++ETFGFRGEAL+SLC L                                  Q GTTV+++ +F TLPVR K+F  N+K+E+ K +  + SYC+I  GV+I+C  ++ + K+  +L T G   + +NI +VFG  QL  +I
Sbjct:   20 IKAIDKQSVHQICSGQVVLSLATAVKELVENSIDAGATNVDVKLKDNGIELVEVSDNGKGVEEQNYEGLTLKHHTSKLKEFSDLIHVETFGFRGEALSSLCALSDLSVVTCHESAQIGARLVYDHDGRLTQCVPHPRQHGTTVTLQKLFSTLPVRHKEFQRNIKKEYSKMIFVLQSYCIISTGVRITCSNQMGQGKRSTVLCTSGSNSMRDNIGAVFGPKQLQSLI 245          

HSP 2 Score: 162.54 bits (410), Expect = 5.178e-42
Identity = 78/191 (40.84%), Postives = 116/191 (60.73%), Query Frame = 2
Query: 1388 KRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            K +F K  F ++E+IGQFN GFII ++  DLFIIDQHA+DEK  FE       +  Q L  P+ L + +  E ++ EN+++F K GF F   E A++  R+ + ++P   N   G  D+ E++ ++ D  G  C   P RVR   AS ACR ++M+GT+L+  +M K++  M  ++ PW C HGRPT+RHL
Sbjct:  269 KDLFNKDMFKEMEIIGQFNLGFIITKIKSDLFIIDQHATDEKYNFEMLQQNTVLKGQRLIVPQSLHLPAISETVLMENLEIFRKNGFDFLIDEDAQVMDRVKLVSLPTSKNWTFGPNDIEELIFMLSDSPGIMC--RPSRVRQMFASRACRKSVMVGTALNTSEMKKLVLHMGEIEQPWNCPHGRPTMRHL 457          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Match: pms1 (PMS1 homolog 1, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030616-528])

HSP 1 Score: 162.925 bits (411), Expect = 3.656e-40
Identity = 113/366 (30.87%), Postives = 178/366 (48.63%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC----------------------------------FLGQKGTTVSIRNIFHTLPVRRKQFLGNLKR---EFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVF---KSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHN------PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYS 1012
            +K +  +T + +CSSQ + S+   +KELIENSLDA S  +E++L+N+G D IEV DNG+GI   +      ++ TSK+   +DL  LET+GFRGEAL S+C                                   LGQ GTTV   N+F  LPVRR Q+  N K+   E  +  N + +Y +I   ++++   +  NK V+     +      + +V G   +  M  L  +H+  Q               +I + G+  +P        SS + K F++VN RP    ++ +LI + Y              PTF+++I++P  TVDVN+ PDK  ++L N+ EV   ++  ++S +   GYS
Sbjct:    1 MKALPPETVRLLCSSQVITSVLNVVKELIENSLDAGSSSLEVKLENYGLDRIEVRDNGSGIKATDVSVMAVKHYTSKISCHEDLEQLETYGFRGEALASICAISEVIITTKTADDDFSIQYSVDHNGQIVSQKPSHLGQ-GTTVCAANLFKNLPVRR-QYYSNTKKCKDELKRVQNLLMAYAVIKPELRVT---LSHNKAVVWQKSRVSDHRTALMAVLGAASVANM--LPVQHHQEQ--------------PEIHIDGFFPKPGSDLNSTSSSTTDKSFIFVNSRPVHHKEILKLIKQYYTSAQSNSESVSRRYPTFMMNITIPASTVDVNLTPDKTEVMLQNKDEVLLSVETMLISLY---GYS 342          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Match: pms1 (PMS1 homolog 1, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030616-528])

HSP 1 Score: 162.925 bits (411), Expect = 3.721e-40
Identity = 113/366 (30.87%), Postives = 178/366 (48.63%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC----------------------------------FLGQKGTTVSIRNIFHTLPVRRKQFLGNLKR---EFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVF---KSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHN------PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYS 1012
            +K +  +T + +CSSQ + S+   +KELIENSLDA S  +E++L+N+G D IEV DNG+GI   +      ++ TSK+   +DL  LET+GFRGEAL S+C                                   LGQ GTTV   N+F  LPVRR Q+  N K+   E  +  N + +Y +I   ++++   +  NK V+     +      + +V G   +  M  L  +H+  Q               +I + G+  +P        SS + K F++VN RP    ++ +LI + Y              PTF+++I++P  TVDVN+ PDK  ++L N+ EV   ++  ++S +   GYS
Sbjct:    1 MKALPPETVRLLCSSQVITSVLNVVKELIENSLDAGSSSLEVKLENYGLDRIEVRDNGSGIKATDVSVMAVKHYTSKISCHEDLEQLETYGFRGEALASICAISEVIITTKTADDDFSIQYSVDHNGQIVSQKPSHLGQ-GTTVCAANLFKNLPVRR-QYYSNTKKCKDELKRVQNLLMAYAVIKPELRVT---LSHNKAVVWQKSRVSDHRTALMAVLGAASVANM--LPVQHHQEQ--------------PEIHIDGFFPKPGSDLNSTSSSTTDKSFIFVNSRPVHHKEILKLIKQYYTSAQSNSESVSRRYPTFMMNITIPASTVDVNLTPDKTEVMLQNKDEVLLSVETMLISLY---GYS 342          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Match: prph2 (peripherin 2 (retinal degeneration, slow) [Source:Xenbase;Acc:XB-GENE-985594])

HSP 1 Score: 229.95 bits (585), Expect = 6.362e-62
Identity = 125/329 (37.99%), Postives = 197/329 (59.88%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ--VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFN-ISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKR 928
            IK I+ ++  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+LK +GA+ IEV DNG G+  + F+  T ++ TSKL++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +F+TLPVR K+F  NLK+EF K +  + +YC+I  GV+I+C  ++ + K+  V+ S+     + ENI +VFGQ QL  +I    +   ++ + +E+  I +        +SG+IS+       S++ +QF ++N+RPC+  KV +++ E Y + N+   P  V++I +  E VD+N+ PDKR
Sbjct:   13 IKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDNGCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLVYDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRITCTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPF-VQLPPSETVCEEYGLIHEDTPHGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVYHLYNRHQYPFVVLNICVSSECVDINVTPDKR 340          

HSP 2 Score: 136.346 bits (342), Expect = 9.402e-32
Identity = 71/208 (34.13%), Postives = 112/208 (53.85%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+  +N+ AE+EL++   K+ F  +E+IGQFN GFII +L+ DLF+IDQHA+DEK  FE    Q E +   LA                                       +++ ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+
Sbjct:  646 RFRAKINPGDNQAAEDELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEML--QQETNWALLA---------------------------------------LYLISLPTSKNWTFGQQDIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNVHEMKKLVTHMGEIEHPWNCPHGRPTMRHI 810          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Match: prph2 (peripherin 2 (retinal degeneration, slow) [Source:Xenbase;Acc:XB-GENE-985594])

HSP 1 Score: 230.335 bits (586), Expect = 6.433e-62
Identity = 130/352 (36.93%), Postives = 207/352 (58.81%), Query Frame = 2
Query:    2 NLFKIFYVLN*LINLM------NIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ--VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFN-ISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKR 928
            +L KIF  L  ++++        IK I+ ++  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+LK +GA+ IEV DNG G+  + F+  T ++ TSKL++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +F+TLPVR K+F  NLK+EF K +  + +YC+I  GV+I+C  ++ + K+  V+ S+     + ENI +VFGQ QL  +I    +   ++ + +E+  I +        +SG+IS+       S++ +QF ++N+RPC+  KV +++ E Y + N+   P  V++I +  E VD+N+ PDKR
Sbjct:    7 HLPKIFLSLISVLDMTCSSLAKAIKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDNGCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLVYDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRITCTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPF-VQLPPSETVCEEYGLIHEDTPHGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVYHLYNRHQYPFVVLNICVSSECVDINVTPDKR 357          

HSP 2 Score: 182.956 bits (463), Expect = 1.740e-46
Identity = 83/209 (39.71%), Postives = 137/209 (65.55%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+  +N+ AE+EL++   K+ F  +E+IGQFN GFII +L+ DLF+IDQHA+DEK  FE    +  +  Q L  P++L +++ +E ++ +N+D+F K GF F F +EA +  R+ + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+
Sbjct:  629 RFRAKINPGDNQAAEDELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEMLQQETVLQGQRLIAPQKLHLTAVNETVLIDNLDIFKKNGFDFIFDEEAPITERVKLISLPTSKNWTFGQQDIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNVHEMKKLVTHMGEIEHPWNCPHGRPTMRHI 835          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Match: prph2 (peripherin 2 (retinal degeneration, slow) [Source:Xenbase;Acc:XB-GENE-985594])

HSP 1 Score: 229.95 bits (585), Expect = 1.011e-61
Identity = 125/329 (37.99%), Postives = 197/329 (59.88%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ--VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFN-ISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKR 928
            IK I+ ++  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+LK +GA+ IEV DNG G+  + F+  T ++ TSKL++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +F+TLPVR K+F  NLK+EF K +  + +YC+I  GV+I+C  ++ + K+  V+ S+     + ENI +VFGQ QL  +I    +   ++ + +E+  I +        +SG+IS+       S++ +QF ++N+RPC+  KV +++ E Y + N+   P  V++I +  E VD+N+ PDKR
Sbjct:   15 IKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDNGCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLVYDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRITCTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPF-VQLPPSETVCEEYGLIHEDTPHGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVYHLYNRHQYPFVVLNICVSSECVDINVTPDKR 342          

HSP 2 Score: 182.956 bits (463), Expect = 2.103e-46
Identity = 83/209 (39.71%), Postives = 137/209 (65.55%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+  +N+ AE+EL++   K+ F  +E+IGQFN GFII +L+ DLF+IDQHA+DEK  FE    +  +  Q L  P++L +++ +E ++ +N+D+F K GF F F +EA +  R+ + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+
Sbjct:  633 RFRAKINPGDNQAAEDELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEMLQQETVLQGQRLIAPQKLHLTAVNETVLIDNLDIFKKNGFDFIFDEEAPITERVKLISLPTSKNWTFGQQDIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNVHEMKKLVTHMGEIEHPWNCPHGRPTMRHI 839          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Match: prph2 (peripherin 2 (retinal degeneration, slow) [Source:Xenbase;Acc:XB-GENE-985594])

HSP 1 Score: 229.565 bits (584), Expect = 1.209e-61
Identity = 125/329 (37.99%), Postives = 197/329 (59.88%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ--VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFN-ISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKR 928
            IK I+ ++  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+LK +GA+ IEV DNG G+  + F+  T ++ TSKL++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +F+TLPVR K+F  NLK+EF K +  + +YC+I  GV+I+C  ++ + K+  V+ S+     + ENI +VFGQ QL  +I    +   ++ + +E+  I +        +SG+IS+       S++ +QF ++N+RPC+  KV +++ E Y + N+   P  V++I +  E VD+N+ PDKR
Sbjct:   13 IKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDNGCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLVYDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRITCTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPF-VQLPPSETVCEEYGLIHEDTPHGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVYHLYNRHQYPFVVLNICVSSECVDINVTPDKR 340          

HSP 2 Score: 169.474 bits (428), Expect = 3.647e-42
Identity = 83/209 (39.71%), Postives = 135/209 (64.59%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+  +N+ AE+EL++   K+ F  +E+IGQFN GFII +L+ DLF+IDQHA+DEK  FE    Q E +   L    +L +++ +E ++ +N+D+F K GF F F +EA +  R+ + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+
Sbjct:  633 RFRAKINPGDNQAAEDELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEML--QQETNWALL----KLHLTAVNETVLIDNLDIFKKNGFDFIFDEEAPITERVKLISLPTSKNWTFGQQDIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNVHEMKKLVTHMGEIEHPWNCPHGRPTMRHI 833          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Match: prph2 (peripherin 2 (retinal degeneration, slow) [Source:Xenbase;Acc:XB-GENE-985594])

HSP 1 Score: 229.565 bits (584), Expect = 1.258e-61
Identity = 125/329 (37.99%), Postives = 197/329 (59.88%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ--VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFN-ISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKR 928
            IK I+ ++  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+LK +GA+ IEV DNG G+  + F+  T ++ TSKL++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +F+TLPVR K+F  NLK+EF K +  + +YC+I  GV+I+C  ++ + K+  V+ S+     + ENI +VFGQ QL  +I    +   ++ + +E+  I +        +SG+IS+       S++ +QF ++N+RPC+  KV +++ E Y + N+   P  V++I +  E VD+N+ PDKR
Sbjct:   13 IKPIDRKSVHQICSGQVVLSLATAVKELLENSIDAGATSIDIKLKEYGAESIEVSDNGCGVEENNFEGLTLKHHTSKLQDFSDLISVETFGFRGEALSSLCALSDLSIVTCHKTAKVGTRLVYDHNGKIIQKSPVSRQQGTTVSIQQLFYTLPVRHKEFQRNLKKEFTKMVQVLQAYCIISTGVRITCTNQVGQGKRNPVVCSSGSTSDVKENIGAVFGQKQLQSLIPF-VQLPPSETVCEEYGLIHEDTPHGFYNISGYISRCDHGVGRSSTDRQFFFINQRPCDPAKVSKIVNEVYHLYNRHQYPFVVLNICVSSECVDINVTPDKR 340          

HSP 2 Score: 182.57 bits (462), Expect = 2.199e-46
Identity = 83/209 (39.71%), Postives = 137/209 (65.55%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+  +N+ AE+EL++   K+ F  +E+IGQFN GFII +L+ DLF+IDQHA+DEK  FE    +  +  Q L  P++L +++ +E ++ +N+D+F K GF F F +EA +  R+ + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+
Sbjct:  633 RFRAKINPGDNQAAEDELRKEISKEMFAKMEIIGQFNLGFIITKLDSDLFMIDQHATDEKYNFEMLQQETVLQGQRLIAPQKLHLTAVNETVLIDNLDIFKKNGFDFIFDEEAPITERVKLISLPTSKNWTFGQQDIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNVHEMKKLVTHMGEIEHPWNCPHGRPTMRHI 839          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Match: Pms2 (PMS1 homolog2, mismatch repair system component [Source:MGI Symbol;Acc:MGI:104288])

HSP 1 Score: 251.906 bits (642), Expect = 5.862e-69
Identity = 133/350 (38.00%), Postives = 210/350 (60.00%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ ++  +ICS Q V+S++ A+KELIENS+DA +  I++RLK++G D+IEV DNG G+    F+    ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   KGTTVS++++F+TLPVR K+F  N+K+E+ K +  + +YC+I  GV++SC  ++ + K Q ++ T G  G+ ENI SVFGQ QL  +I    +   +  + +E+ +S     + +  +SG+ISQ T     S + +QF ++N+RPC+  KV +L+ E Y + N+   P  V+++S+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:   15 IKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQHLFYTLPVRYKEFQRNIKKEYAKMVQVLQAYCIISAGVRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLIPFV-QLPPSDAVCEEYGLSTSRTPQNLFYVSGFISQCTHGAGRSATDRQFFFINQRPCDPAKVSKLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 363          

HSP 2 Score: 175.637 bits (444), Expect = 3.212e-44
Identity = 89/267 (33.33%), Postives = 154/267 (57.68%), Query Frame = 2
Query: 1160 IQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            I  + P  Q +   +++   KM   +V+ +   ++ + +   L    A+N    ++  K++++I    N+ AE+EL++   K  F ++E++GQFN GFI+ +L +DLF++DQHA+DEK  FE       + +Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  587 ISQRLPGPQSTSAAEVDVAIKMNKRIVLLEFSLSSLAKRMKQLQHLKAQNKHELSYR-KFRAKICPGENQAAEDELRKEISKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHV 850          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Match: Pms2 (PMS1 homolog2, mismatch repair system component [Source:MGI Symbol;Acc:MGI:104288])

HSP 1 Score: 181.03 bits (458), Expect = 2.488e-48
Identity = 94/226 (41.59%), Postives = 139/226 (61.50%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMI 625
            IK I+ ++  +ICS Q V+S++ A+KELIENS+DA +  I++RLK++G D+IEV DNG G+    F+    ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   KGTTVS++++F+TLPVR K+F  N+K+E+ K +  + +YC+I  GV++SC  ++ + K Q ++ T G  G+ ENI SVFGQ QL  +I
Sbjct:   15 IKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQHLFYTLPVRYKEFQRNIKKEYAKMVQVLQAYCIISAGVRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLI 240          

HSP 2 Score: 160.614 bits (405), Expect = 2.567e-41
Identity = 74/189 (39.15%), Postives = 117/189 (61.90%), Query Frame = 2
Query: 1394 IFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +F K  F ++E++GQFN GFI+ +L +DLF++DQHA+DEK  FE       + +Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  266 LFYKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHV 452          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Match: Pms1 (PMS1 homolog 1, mismatch repair system component [Source:MGI Symbol;Acc:MGI:1202302])

HSP 1 Score: 140.198 bits (352), Expect = 2.157e-33
Identity = 105/359 (29.25%), Postives = 166/359 (46.24%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC----------------------------------FLGQKGTTVSIRNIFHTLPVRRKQFLGNLKR---EFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKS---SNSSKQFLYVNRRPCELPKVKRLI-----AECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            +K++   T + + SSQ + S+ + +KELIENSLDA +  IE++L+N+G D IE+ DNG GI   +      +  TSK+ + +DL NL T+GFRGEAL S+C                                   LGQ GTTV+   +F  LPV RKQF    K+   E     + + SY ++   V+I+      NK VI     +      + SV G   + G +E   +H                   +I LSG+  +      S   S   + F+++N RP     + +LI      +C +   + + P F + I +P   VD+N+ PDK  +LL N+  V   ++  +++C+
Sbjct:    1 MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKLENYGFDKIEIRDNGEGIKAVDVPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICNVAEVVVTTRTSADDFSTQYVLDGSGHILSQKPSHLGQ-GTTVTALKLFKNLPV-RKQFYSTAKKCKDELKNVQDLLISYGVLKPDVRITFV---HNKAVIWQKSRVPDHRMALMSVLG-TAVMGNMESVEQH---------------CEQSQIYLSGFFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRRYYNLKCLKESTRLY-PIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLMMTCY 337          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Match: Pms1 (PMS1 homolog 1, mismatch repair system component [Source:MGI Symbol;Acc:MGI:1202302])

HSP 1 Score: 140.198 bits (352), Expect = 5.320e-33
Identity = 105/358 (29.33%), Postives = 166/358 (46.37%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC----------------------------------FLGQKGTTVSIRNIFHTLPVRRKQFLGNLKR---EFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKS---SNSSKQFLYVNRRPCELPKVKRLIAECY--RVMNKTHN--PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            +K++   T + + SSQ + S+ + +KELIENSLDA +  IE++L+N+G D IE+ DNG GI   +      +  TSK+ + +DL NL T+GFRGEAL S+C                                   LGQ GTTV+   +F  LPV RKQF    K+   E     + + SY ++   V+I+      NK VI     +      + SV G   + G +E   +H                   +I LSG+  +      S   S   + F+++N RP     + +LI   Y  + + ++    P F + I +P   VD+N+ PDK  +LL N+  V   ++  +++C+
Sbjct:    1 MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKLENYGFDKIEIRDNGEGIKAVDVPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICNVAEVVVTTRTSADDFSTQYVLDGSGHILSQKPSHLGQ-GTTVTALKLFKNLPV-RKQFYSTAKKCKDELKNVQDLLISYGVLKPDVRITFV---HNKAVIWQKSRVPDHRMALMSVLG-TAVMGNMESVEQH---------------CEQSQIYLSGFFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRRYYNLKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLMMTCY 337          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Match: Mlh1 (mutL homolog 1 [Source:MGI Symbol;Acc:MGI:101938])

HSP 1 Score: 123.635 bits (309), Expect = 5.384e-28
Identity = 99/369 (26.83%), Postives = 168/369 (45.53%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGIS--ENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQ---FLYVNRRPCELPKVKRLIAECYRV-MNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTL 1042
            I+R++     RI + + +   A AIKE+IEN LDA S  I++ +K  G  +I++ DNGTGI   + D    R TTSKL+ F+DL ++ T+GFRGEAL S+  +                                 G +GT +++ ++F+ +  RRK  L N   E+ K L  +  Y +   G+  S   + K  + +   R +   +  +NI+S+FG      +IE+  E                      +++G+IS       ++ S K+    L++N R  E   +++ I   Y   + K  +P   +S+ +  + VDVN+ P K  +   ++  +   ++  I S  L S  S+ Y    QTL
Sbjct:    8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRRKA-LKNPSEEYGKILEVVGRYSIHNSGISFS---VKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTL----------------AFKMNGYISN------ANYSVKKCIFLLFINHRLVESAALRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLGSNSSRMY--FTQTL 348          
BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Match: sp|F1NQJ3|PMS2_CHICK (Mismatch repair endonuclease PMS2 OS=Gallus gallus OX=9031 GN=PMS2 PE=2 SV=3)

HSP 1 Score: 253.832 bits (647), Expect = 1.021e-68
Identity = 134/350 (38.29%), Postives = 213/350 (60.86%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IKRI+ ++  RICS Q V+S+  A+KEL+ENSLDA +  I++RLK+ GA++IEV DNG G+    F+  T ++ TSK+++F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVSI+ +FHTLPVR K+F  N+K+E+ K +  + +YC+I +GV+I+C  ++ + K+  ++ST G   + ENI +VFG+ QL  +I    +   N+ + +E+ +      EK+  ++G+IS+       S + +QF ++N+RPC+  KV +L+ E Y + NK   P  V++I +  E VD+N+ PDKR +LL  +  + A++K S++  F
Sbjct:   14 IKRIDRESVHRICSGQVVLSLGTAVKELVENSLDAGATNIDVRLKDHGAELIEVSDNGGGVEEENFEGLTLKHYTSKIQDFSDLIHVETFGFRGEALSSLCALSDVTISTCHKSAKVGTRLVFDHNGKITQKAPYPRQQGTTVSIQQLFHTLPVRHKEFQRNIKKEYAKMVQILQAYCIISKGVRINCTNQVGQGKKSPVVSTTGGPNLKENIGAVFGKKQLQSLIPF-VQLPPNEAVCEEYGLKSTDLPEKLYSITGFISRCDHGVGRSTTDRQFFFINQRPCDPAKVVKLVNEVYHLYNKHQYPFIVLNICVDSECVDINVTPDKRQILLQEEKLLLAILKTSLIEMF 362          

HSP 2 Score: 183.341 bits (464), Expect = 7.741e-46
Identity = 87/212 (41.04%), Postives = 134/212 (63.21%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCL 1963
            +++++IS   N+ AE+EL++   K+ F  +E+IGQFN GFIIA+LN DLFIIDQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R+ + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RH+  L
Sbjct:  654 RFRAKISPGENKVAEDELRKEISKEMFAKMEIIGQFNLGFIIAKLNSDLFIIDQHATDEKYNFEMLQQHTVLQGQKLIAPQNLNLTAVNETVLIENLEIFRKNGFDFVINENAPVTQRVKLISLPTSKNWTFGPQDIDELIFMLSDCPGVMC--RPSRVRQMFASRACRKSVMIGTALNVQEMKKLVTHMGEIEHPWNCPHGRPTMRHIASL 863          
BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Match: sp|P54278|PMS2_HUMAN (Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2)

HSP 1 Score: 251.906 bits (642), Expect = 3.835e-68
Identity = 135/350 (38.57%), Postives = 209/350 (59.71%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNK-QVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ ++  +ICS Q V+S++ A+KEL+ENSLDA +  I+++LK++G D+IEV DNG G+    F+  T ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   +GTTVS++ +F TLPVR K+F  N+K+E+ K +  + +YC+I  G+++SC  ++ + K Q ++ T G   I ENI SVFGQ QL  +I    +   +  + +E+ +S    L  +  +SG+ISQ T     S++ +QF ++NRRPC+  KV RL+ E Y + N+   P  V++IS+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:   15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV-QLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 363          

HSP 2 Score: 176.022 bits (445), Expect = 2.042e-43
Identity = 89/240 (37.08%), Postives = 140/240 (58.33%), Query Frame = 2
Query: 1253 ISANFSM----KYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +  +FSM    K I  L   A+         K++++I    N+ AE+EL++   K  F ++E+IGQFN GFII +LN+D+FI+DQHA+DEK  FE       +  Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RV+   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  616 VPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMC--RPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHI 853          
BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Match: sp|P54279|PMS2_MOUSE (Mismatch repair endonuclease PMS2 OS=Mus musculus OX=10090 GN=Pms2 PE=2 SV=1)

HSP 1 Score: 211.075 bits (536), Expect = 8.159e-55
Identity = 121/354 (34.18%), Postives = 195/354 (55.08%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNIS-----KVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+ ++  +ICS Q ++S++ A+KELIENS+DA +  I++RLK++G D+IEV DNG G+    F+    ++ TSK++ F DL  +ETFGFRGEAL+SLC L                                   KGTTVS++++F+TLPVR K+F  N+K+E+ K +  + +YC+I  GV++SC  ++ + K+  ++ T G  G+ ENI SVFGQ QL  +I    +   +  + +E+ +S     K  +  +       + P  V ++ + S       R P    +   L    Y + N+   P  V+++S+  E VD+N+ PDKR +LL  +  + AV+K S++  F
Sbjct:   15 IKPIDGKSVHQICSGQVILSLSTAVKELIENSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQHLFYTLPVRYKEFQRNIKKEYSKMVQVLQAYCIISAGVRVSCTNQLGQGKRHAVVCTSGTSGMKENIGSVFGQKQLQSLIPF-VQLPPSDAVCEEYGLSTSGRHKTFSTFRASFHSARTAPGGVQQTGSFSSSI----RGPVTQQRSLSLSMRFYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF 363          

HSP 2 Score: 175.637 bits (444), Expect = 2.169e-43
Identity = 89/267 (33.33%), Postives = 154/267 (57.68%), Query Frame = 2
Query: 1160 IQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            I  + P  Q +   +++   KM   +V+ +   ++ + +   L    A+N    ++  K++++I    N+ AE+EL++   K  F ++E++GQFN GFI+ +L +DLF++DQHA+DEK  FE       + +Q L  P+ L +++ +E ++ EN+++F K GF F   E A +  R  + ++P   N   G +D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  +  PW C HGRPT+RH+
Sbjct:  587 ISQRLPGPQSTSAAEVDVAIKMNKRIVLLEFSLSSLAKRMKQLQHLKAQNKHELSYR-KFRAKICPGENQAAEDELRKEISKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHV 850          
BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Match: sp|Q941I6|PMS1_ARATH (DNA mismatch repair protein PMS1 OS=Arabidopsis thaliana OX=3702 GN=PMS1 PE=1 SV=1)

HSP 1 Score: 210.305 bits (534), Expect = 2.653e-54
Identity = 114/345 (33.04%), Postives = 187/345 (54.20%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKN-KQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASI 982
            I+ IN     RICS Q ++ +++A+KEL+ENSLDA +  IEI L+++G D  +V+DNG GISP  F     ++ TSKLE+F DL NL T+GFRGEAL+SLC LG                                 Q GTTV++R +F  LPVR K+F  N+++E+ K ++ + +Y LI +GV+  C     KN K V+L+T+G G + +NI +VFG +    +  ++                 +   E   + G++S+P +    + + +Q+ ++N RP ++PKV +L+ E Y+  +    P  ++   +P    D+N+ PDKR +   +++ V   ++  +
Sbjct:   17 IRPINRNVIHRICSGQVILDLSSAVKELVENSLDAGATSIEINLRDYGEDYFQVIDNGCGISPTNFKVLALKHHTSKLEDFTDLLNLTTYGFRGEALSSLCALGNLTVETRTKNEPVATLLTFDHSGLLTAEKKTARQIGTTVTVRKLFSNLPVRSKEFKRNIRKEYGKLVSLLNAYALIAKGVRFVCSNTTGKNPKSVVLNTQGRGSLKDNIITVFGISTFTSLQPVS-----------------ICVSEDCRVEGFLSKPGQGTGRNLADRQYFFINGRPVDMPKVSKLVNELYKDTSSRKYPVTILDFIVPGGACDLNVTPDKRKVFFSDETSVIGSLREGL 344          

HSP 2 Score: 166.392 bits (420), Expect = 2.716e-40
Identity = 82/207 (39.61%), Postives = 123/207 (59.42%), Query Frame = 2
Query: 1373 AEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIF-MTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVM------------PIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            A  EL+R+FRK+ F  ++V+GQFN GFIIA+L +DLFI+DQHA+DEK  FE       ++ QPL  P  L++S  +E  +  ++D+  + GF  +   +    + F + A+P   N+  G EDL +++  + D    C V             P RVR+ +AS ACRS++MIG  L   +M KI++ ++ L+ PW C HGRPT+RHL
Sbjct:  689 ATSELERLFRKEDFRRMQVLGQFNLGFIIAKLERDLFIVDQHAADEKFNFEHLARSTVLNQQPLLQPLNLELSPEEEVTVLMHMDIIRENGFLLEENPSAPPGKHFRLRAIPYSKNITFGVEDLKDLISTLGDNHGECSVASSYKTSKTDSICPSRVRAMLASRACRSSVMIGDPLRKNEMQKIVEHLADLESPWNCPHGRPTMRHL 895          
BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Match: sp|Q0STR3|MUTL_CLOPS (DNA mismatch repair protein MutL OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=mutL PE=3 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 2.253e-53
Identity = 184/692 (26.59%), Postives = 330/692 (47.69%), Query Frame = 2
Query:   38 INLMNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ--------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHN-PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSC---FLKSGYS------QEYRSI-NQTLSESVNSKFNNNYTL--NLSVNVDNSLRSPHVRKHNLRSPD---KIQTKFPKLQLSDPNQINSCR-KMKLPLVVSQNISANFSMKYISLLDTNAENDIT--NAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKF---LNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRF-QFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVR-SAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTI 1945
            +N +NI  +N  T+ +I + + V   ++ +KEL+ENSLDA +  I I ++N G  +I+++D+G+G+ P + +K  + + TSK+++  D+ ++ T GFRGEAL S+  + +                                +GT + +RN+F  +P R+K FL    RE     + +    L    V     K+  N + IL+T G G + + I++++G++    +I    EH                  +   + G+I   T    S N+  Q L+VN+R  +   +   +   +R  N T   P FV+ I    E +DVNI P K  +   ++  +F ++  ++ S    ++K  ++      +++ ++  + + ES++ + +    L  N++  V +  R   +  +N  S D   K +   P   LS  NQ  S +    L     + +SA   + Y  +L  N   D    N ++    S+   N N       +RI+R+  F  L+VIGQFNK +I+A  +  L++IDQHA+ EK  FEK+   + + ++  QPL  P  + + + D     EN ++F K GF+   F +      I +  VP   + +  TE +  M+  +K  G+   V    V+ + IAS +CR+A+     LS ++M+ +++ +  + DP+ C HGRPTI
Sbjct:    1 MNRINI--LNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDDGSGVHPEDVEKAFNPHATSKIKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDMGKELIISGGEKESLTDCSMNRGTQIEVRNLFFNVPARKK-FLKTTARESALINDLVNRISLANPDVSF---KLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFE-EHK-----------------DTASVYGFIGNDTLARASRNN--QSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIHPTKSEIKFKDERFIFKLVFDAVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEISTLEKLKENINYKVSDDKRKEEIYSYN-PSKDYEAKTEVNIPVDFLSKENQEESSKFNNSLENNDFKEVSAKREISYDPILIKNELKDKVSENTYDSLESSDYKCNKNEYGNSLEERIYREAKFPKLKVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPLVVTLPTEDYLYYDENKEIFEKAGFKISDFGDN----SIRIEEVPYFLDKLNPTELIISMINNLKKMGTGETV---EVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTI 658          
BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Match: A0A4S2LJX3 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006689 PE=4 SV=1)

HSP 1 Score: 437.187 bits (1123), Expect = 1.146e-131
Identity = 264/747 (35.34%), Postives = 394/747 (52.74%), Query Frame = 2
Query:   80 QRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFL--GNLKREFDKALNYITSYCLICEGVQISCCKIDKN--KQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKS------------------SNSSKQFLYVNRRPCELPKVKRLIAECYRVMNK------------------THNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLK------SGYSQEYRSINQTLSESVNSKFNNNYTL-NLSVNVDNSLRSPHV--------RKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMK--------LPLVVS---QNISANFSMKYI----SLLDTNAENDITNAF------------NGKYK-SEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGS-TCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
             RICS Q VV++A+A+KEL+ENS+DA + KI++RLK FG++ IEV+DNGTGI   +F+  T +++TSKL  FDDL +++TFGFRGEAL+SLC L +                                 +GTTV +  +FH LPVRR+       L +EF + +N +T+YCLI  GVQISC +I KN  K  ++S      + +NI  V+GQ+Q + ++EL    +I  DILDEFN++       I +SG+I++P+ +  +                  S S +QF+YVN RPCELP+V RL+ + +R  +K                  T  P FV+ + +P  TVD+N+ PDKR LLL ++  V A+ KA ++    +          Q   +++Q++          + TL + +++V +  R+P V        R   +   D+  T       + P   N    +         LP   +   Q  S +FSM  +    S +D N    IT               NG++      S  + TAE EL   F K  FN+L+++GQFN GFI+AR  QDLFIIDQHASDEK +FE+       + QPL  P+ L++S   E+++  N+D+F K GF F+  E A    ++ + A P     + G  D+ EML ++ +  S  C   P R+R+ +AS ACRSA+MIGT+L + +M +I++ M ++  PW C HGRPT+RHL  L 
Sbjct:   19 HRICSGQVVVTLASAVKELVENSIDAGATKIDVRLKEFGSESIEVIDNGTGIIERDFEAITGKHSTSKLREFDDLQSVQTFGFRGEALSSLCQLAKVVVHTCSSGAPVGTRMEFDTNGDILARRPLARSRGTTVIVNQLFHNLPVRRRHLTDPAQLAKEFARTVNLLTAYCLISVGVQISCVRISKNGEKIPVVSNGSASSLKDNIFGVYGQSQASSLLELAPISSIPSDILDEFNVNDALEFGSISISGFITKPSTLQSADASSPSGSSKGRAASGARSTSDRQFVYVNGRPCELPRVARLVTDVWRRCSKEALAVSNDGLQMPASNASTSFPFFVLMLRMPTGTVDINLTPDKRTLLLHHERYVLALTKAILVQTLFRNSNVHLPSVQQSCSTLDQSIIVIPADCPPEHCTLSSPNLSVISRKRTPFVDDSNRWGKRAATIDFTDQRSTPLCASHKTPPKSANGVAGLGESFEIVDLLPTTETLSRQQASVHFSMSDLRAAWSTMDENRTTPITQVASQHPLDDVDLVSNGEFSLGSFRSTESDTAESELSTYFDKATFNELQIVGQFNLGFIVARHAQDLFIIDQHASDEKYRFEQLFENYRFTCQPLVAPQALELSVAQEQLLLNNLDVFAKNGFAFRVDENAPCGRQVQLVATPMLEGHIFGRSDIEEMLFVLSESCSRRC--RPSRLRTILASRACRSAVMIGTALDHAKMQRIVRNMGTMVHPWNCPHGRPTMRHLFHLG 763          
BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Match: G7Y8X1 (DNA mismatch repair protein PMS2 OS=Clonorchis sinensis OX=79923 GN=CLF_103022 PE=4 SV=1)

HSP 1 Score: 427.557 bits (1098), Expect = 4.952e-128
Identity = 262/758 (34.56%), Postives = 395/758 (52.11%), Query Frame = 2
Query:   86 ICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFT-------------SRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFL--GNLKREFDKALNYITSYCLICEGVQISCCKIDKN--KQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEV------------------FKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNK------------------THNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKS------GYSQEYRSINQTLSESVNSKFNNNYTLN-LSVNVDNSLRSPHV--------RKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMK--------LPLVVS---QNISANFSMKYI----SLLDTNAENDITNAF------------NGKYK-SEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGS-TCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            ICS Q VV++A+A+KEL+ENS+DA + KI++RLK FG++ IEV+DNGTGI   +F+  +              +++TSKL  FDDL +++TFGFRGEAL+SLC L +                                 +GTTV +  +FH LPVRR+       L +EF + +N +T+YCL+  GVQISC +I KN  K  ++S      + +NI  V+GQ+Q + ++ELT   +I  DILDEFN++       I +SG+I++P+ +                     S S +QF+YVN RPCELP+V RL+ + +R  +K                  T  P FV+ + +P  TVD+N+ PDKR LLL ++  V A+ KA ++    ++         Q   +++Q++        + + TL+  +++V +  R+P V        R   +   D+  T       + P   N    +         LP   +   Q  S +FSM  +    S L+ N    +T               NG++      S  N TAE EL   F K  FN+L+++GQFN GFI+AR  QDLFIIDQHASDEK +FE+       + QPL  P+ L++S   E+++  N+D+F K GF F+  E +    ++ + A P     + G  D+ EML ++ +  S  C   P R+R+ +AS ACRSAIMIGT+L + +M +I++ M ++  PW C HGRPT+RHL  L 
Sbjct:   21 ICSGQVVVTLASAVKELVENSIDAGATKIDVRLKEFGSESIEVIDNGTGIIERDFEAISVLVLGPTYAFVLAGKHSTSKLREFDDLQSVQTFGFRGEALSSLCQLAKVVVHTCASDAPVGTRMEFDANGDILARRPLARSRGTTVIVNQLFHNLPVRRRHLTDPAQLAKEFARTVNLLTAYCLVSVGVQISCVRISKNGEKIPVVSNGSASSLKDNIFGVYGQSQASTLLELTPTSSIPSDILDEFNVNDAVEFGSISISGFITKPSTLQSADASSPSASSKGRAASGARSTSDRQFIYVNGRPCELPRVARLVTDVWRRCSKEALAVSNDGLQMPASNASTAFPFFVLMLQMPTGTVDINLTPDKRTLLLHHERYVLALTKAILVQTLFRNPNVHLPSVQQSCSTLDQSVIGIPADCPSEHCTLSSPTLSVSSRKRTPFVDDSDRWGKRAATIDLTDQRSTPLRASHKTPPKSTNGVAGLGESFEIVDLLPTTETLSRQQASVHFSMSDLRAAWSTLEDNRTTPVTEVASQHPFDDIDLVSNGEFSLGSFRSTENDTAESELSTYFDKATFNELQIVGQFNLGFIVARHAQDLFIIDQHASDEKYRFEQLFENYRFTCQPLVVPQALELSVAQEQLLLNNLDVFAKNGFAFRVDENSPCGRQVQLVATPMLEGHIFGRSDIEEMLFVLSESCSRRC--RPSRLRTILASRACRSAIMIGTALDHAKMQRIVRNMGTMVHPWNCPHGRPTMRHLFHLG 776          
BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Match: A0A504Z4G0 (Mismatch repair endonuclease PMS2 OS=Fasciola gigantica OX=46835 GN=FGIG_09358 PE=4 SV=1)

HSP 1 Score: 415.231 bits (1066), Expect = 1.013e-123
Identity = 261/762 (34.25%), Postives = 392/762 (51.44%), Query Frame = 2
Query:   50 NIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQF--LGNLKREFDKALNYITSYCLICEGVQISCCKIDKN--KQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEV---------------------FKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNK------------------THNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNVDNSLRSPHVRKH-------NLRSPDKIQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNG--------------KYKSEISS------------------------NNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGS-TCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            +I  ++     +IC+ Q VV++A+AIKEL+ENS+DA++ KI+IRLK++G + IEV+DNG GI   +F++ T ++ TSKL +F+DL ++ TFGFRGEAL SLC L +                                 +GTTV +  +FH LPVRRK       + +EF KA+N +T+YCL+    QI+C ++ K+  K +++S      + +NI +VFGQ+QLN +I L     +  D+L EF I      E I+L G+IS+P  V                        S++ +QF++VN RPC++PK+ R++ + +R  ++                  +  P FV+   +P + VDVN+ PDKR LLL NQ++V A+ KA +L           +RS    L    N  F  + +    VN+   L SP V K        ++++  K+ T+   LQ +    I S  + +L  + S     +   + I   D    + + +A N               K K  +SS                         ++  AE EL   F K  F++LEV+GQFN GFII   NQDLFIIDQHASDEK +FE+         QPL  P+ L +S G E+++  N+D+F K GF F   E A    ++ +TA P   N V G  D+ EML ++ +  S  C   P R+R  +AS ACRSA+MIGT+L + +M +I+++M +++ PW C HGRPT+RHL  L 
Sbjct:    5 SISHLDKAIVNKICAGQVVVTLASAIKELLENSIDAEATKIDIRLKDYGCESIEVVDNGLGIEEAQFERITKKHCTSKLRSFEDLASVTTFGFRGEALFSLCQLAELIIHTCSADATYGTRLQFDANGCIAAKRPLARSRGTTVIVNRLFHNLPVRRKNLSEPAQMIKEFSKAVNVLTAYCLVAVNKQITCTRVGKSGEKVLVVSNGASTSLQDNIAAVFGQSQLNCLIPLLQVTTVQSDVLAEFGIKDPILDENIKLHGYISKPPGVEANVSIRPPGSRVSPKTDNAGHGRSSADRQFVFVNGRPCDMPKINRMVTDLWRRCSRETISLSSSGLRMPVQSTSSRYPVFVLCFQVPTDIVDVNLTPDKRTLLLQNQNQVLALTKAVLLQTL--------FRSNGVDLLSLTNKSFETDVSAIEIVNLPIDLLSPEVPKKRPFVFEPSVQASKKVPTENCLLQNNYSLVIPSTEEPRLVPIPSLAFEKSGYAENIDKFDYRDADGVGSAENPLELRPSVPLEFSFTKLKQSLSSVSIDLSTVCSTSSTSAFSLGNFRAEDSNAAEGELTTYFSKSSFHELEVVGQFNLGFIIGLHNQDLFIIDQHASDEKYRFEQLCADHRFVCQPLVVPRALDLSVGQEQLLLSNLDVFAKSGFAFHVDESAPCGRQVQLTATPMVGNKVFGRADVEEMLFVLAESCSRNC--RPTRLRDILASRACRSAVMIGTALDHGKMRRIIRKMGTMEHPWNCPHGRPTMRHLFHLG 756          
BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Match: W6USS9 (Mismatch repair endonuclease PMS2 OS=Echinococcus granulosus OX=6210 GN=EGR_00630 PE=4 SV=1)

HSP 1 Score: 410.609 bits (1054), Expect = 1.834e-122
Identity = 243/723 (33.61%), Postives = 394/723 (54.50%), Query Frame = 2
Query:   44 LMNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGN--LKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGG--ISENIKSVFGQNQ---LNGMIELTTEHNINQDILDEFNISKVAN-LEKIELSGWISQP----TEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYR------VMNKTHN------------PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNVDNSLRSPHVRKHNLRSPDKIQTKFPKLQLSDPNQI-----------NSCRK---MKLPLVVSQNISANFSM-KYISLLDTNAENDI--TNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGS-TCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            + +++ ++ Q+  ++CSSQ VV++  AIKELIENS+DA++ KIEIRLKN+G+D IEV+D+G GI   +F+     ++TSK+++F+D++   +FGFRGEA+ SLC +                                   +GTTV +  +FHTLPVRR+       L +EF +A+  I+SYCL+  GVQ+ C +ID+     L    + G  +S NI +V+GQ Q   L  ++E+T +  +  ++ +E+ +   A  L++I + G+IS P    T V   S++ +QF+ +N RPC+ P+  RL  + +R      + +K+ +            P  V+ I+LP+  VDVN+ PDKR LLL  +  V   +KA++ +  ++    Q   ++  + S +      +   + L+       + P +  H    P+       K +LS P+             +S R+     LPL+  +++   FS+ + +        +D+       G++ + ++ +    A+ EL  IFRK++F D+ VIGQFNKGFI+ +  +DLFI+DQHASDEK +FE      + +SQPL  P+RL +++  E ++ EN+D+F++ GF F   E A L  R  + + P     V G  D+ EML ++ +  S  C   P R+R  +AS ACRSA+MIGT L + QM +I+  MS+++ PW C HGRPT+RHL  L 
Sbjct:    1 MSSVRTLDAQSVHKLCSSQVVVTLGIAIKELIENSIDAEATKIEIRLKNYGSDSIEVVDDGLGIDEADFETLGKSHSTSKIQDFNDISKTSSFGFRGEAIFSLCQVADVTIHTRTERAKVGTRLEFTNSGGLKSRRPLARSRGTTVCVERLFHTLPVRRRYLTDRTRLSKEFSQAIALISSYCLMVTGVQLVCYRIDRKGTKTLVVSNMEGELVSSNIAAVYGQAQRFQLESLVEITNDFVVTDELKEEYKVKLSAEELDEIRIFGFISMPPMGSTNVVGRSSADRQFVSINGRPCDFPQFTRLATDVWRRCCRESLFSKSQSLGMPSRSTTSAFPVLVLLINLPRAKVDVNLSPDKRQLLLHWERAVVMKLKAALTATLVRVDGEQSIANLPVSSSTAAAVATASEAAVGLT-------QQPPISAHLPPQPESSSQNGKKPRLSTPSSSPIASQKPVFSSDSARRNYNRHLPLLNRESVRVEFSVGRLLKYWAARGSSDVLVETPSTGEFHANLTES---AAQSELTSIFRKEWFRDMRVIGQFNKGFIVCQHEEDLFIVDQHASDEKHRFENLCANHQFTSQPLVVPQRLVLNAVQEHLLEENMDVFSESGFIFSTDENAPLGQRFHLISAPMSEGKVFGLADIEEMLFVLSESLSRNC--RPSRLRDMLASRACRSAVMIGTVLDHKQMARIVSNMSTMEHPWNCPHGRPTMRHLFHLG 711          
BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Match: A0A4S2LJN2 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006689 PE=4 SV=1)

HSP 1 Score: 401.364 bits (1030), Expect = 8.700e-119
Identity = 251/721 (34.81%), Postives = 376/721 (52.15%), Query Frame = 2
Query:   80 QRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFL--GNLKREFDKALNYITSYCLICEGVQISCCKIDKN--KQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKS------------------SNSSKQFLYVNRRPCELPKVKRLIAECYRVMNK------------------THNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLK------SGYSQEYRSINQTLSESVNSKFNNNYTL-NLSVNVDNSLRSPHV--------RKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMK--------LPLVVS---QNISANFSMKYI----SLLDTNAENDITNAF------------NGKYK-SEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGS-TCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKIL 1888
             RICS Q VV++A+A+KEL+ENS+DA + KI++RLK FG++ IEV+DNGTGI   +F+  T +++TSKL  FDDL +++TFGFRGEAL+SLC L +                                 +GTTV +  +FH LPVRR+       L +EF + +N +T+YCLI  GVQISC +I KN  K  ++S      + +NI  V+GQ+Q + ++EL    +I  DILDEFN++       I +SG+I++P+ +  +                  S S +QF+YVN RPCELP+V RL+ + +R  +K                  T  P FV+ + +P  TVD+N+ PDKR LLL ++  V A+ KA ++    +          Q   +++Q++          + TL + +++V +  R+P V        R   +   D+  T       + P   N    +         LP   +   Q  S +FSM  +    S +D N    IT               NG++      S  + TAE EL   F K  FN+L+++GQFN GFI+AR  QDLFIIDQHASDEK +FE+       + QPL  P+ L++S   E+++  N+D+F K GF F+  E A    ++ + A P     + G  D+ EML ++ +  S  C   P R+R+ +AS ACRSA+MIGT+L + +M + L
Sbjct:   19 HRICSGQVVVTLASAVKELVENSIDAGATKIDVRLKEFGSESIEVIDNGTGIIERDFEAITGKHSTSKLREFDDLQSVQTFGFRGEALSSLCQLAKVVVHTCSSGAPVGTRMEFDTNGDILARRPLARSRGTTVIVNQLFHNLPVRRRHLTDPAQLAKEFARTVNLLTAYCLISVGVQISCVRISKNGEKIPVVSNGSASSLKDNIFGVYGQSQASSLLELAPISSIPSDILDEFNVNDALEFGSISISGFITKPSTLQSADASSPSGSSKGRAASGARSTSDRQFVYVNGRPCELPRVARLVTDVWRRCSKEALAVSNDGLQMPASNASTSFPFFVLMLRMPTGTVDINLTPDKRTLLLHHERYVLALTKAILVQTLFRNSNVHLPSVQQSCSTLDQSIIVIPADCPPEHCTLSSPNLSVISRKRTPFVDDSNRWGKRAATIDFTDQRSTPLCASHKTPPKSANGVAGLGESFEIVDLLPTTETLSRQQASVHFSMSDLRAAWSTMDENRTTPITQVASQHPLDDVDLVSNGEFSLGSFRSTESDTAESELSTYFDKATFNELQIVGQFNLGFIVARHAQDLFIIDQHASDEKYRFEQLFENYRFTCQPLVAPQALELSVAQEQLLLNNLDVFAKNGFAFRVDENAPCGRQVQLVATPMLEGHIFGRSDIEEMLFVLSESCSRRC--RPSRLRTILASRACRSAVMIGTALDHAKMQRTL 737          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Match: pms2 (PMS1 homolog 2, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030131-686])

HSP 1 Score: 242.276 bits (617), Expect = 4.166e-67
Identity = 129/353 (36.54%), Postives = 209/353 (59.21%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQ-VILSTRGIGGISENIKSVFGQNQLNGMI---ELTTEHNINQDI-LDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+  +  +ICS Q V+S+A A+KEL+ENS+DA +  ++IRLK+ G +++EV DNG G+    F+  T ++ TSKL  F DL ++ETFGFRGEAL+SLC L                                  Q+GTTVS++ +F TLPVR K+F  N+K+E+ K ++ + SYC+I  GV+I+C  +I + K+  +L T G   + +NI ++FG  QL  +I   +++   NI +D  L+  ++ K    +   +SG++SQ       S + +QF ++N+RPC+  KV +L+ E Y + N+   P   ++I++  E VDVN+ PDKR + L  +  + A++K+S++S +
Sbjct:   10 IKAIDRHSVHQICSGQVVLSLATAVKELVENSVDAGATNVDIRLKDHGTELVEVTDNGKGVEEENFEGLTLKHHTSKLREFSDLIHVETFGFRGEALSSLCALSDLSVVTCHDSTSVGTRLVYDHDGRLVQRAPQPRQQGTTVSLQQLFSTLPVRHKEFQRNIKKEYSKMIHVLQSYCIISTGVRITCTNQIGQGKRNTVLCTSGSQSMRDNIGALFGPKQLQSLIPFQQISPTDNIKEDYGLNGADLPK----DLFTISGYVSQADHGVGRSATDRQFFFINKRPCDPSKVSKLVNEVYHMFNRHQYPFVALNIAVASECVDVNVTPDKRQIFLQEEKFLLAILKSSLISMY 358          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Match: ENSAMXT00000030240.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000042.1:581942:583570:-1 gene:ENSAMXG00000041557.1 transcript:ENSAMXT00000030240.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 155.221 bits (391), Expect = 1.345e-42
Identity = 75/183 (40.98%), Postives = 111/183 (60.66%), Query Frame = 2
Query: 1412 FNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            F ++++IGQFN GFII +L  DLF++DQHA+DEK  FE       +  Q L  P+ L + +  E I+ EN+++F K GF F   E A +  R+ + ++P   N   G  D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+L+  +M K++  M  ++ PW C HGRPT+RHL
Sbjct:    2 FKEMQIIGQFNLGFIITKLRSDLFMVDQHATDEKYNFEMLQQHTVLKGQRLIAPQNLHLPAVSETILIENLEIFKKNGFDFLIDEDAPVMERVKLVSLPTSKNWTFGPSDIEELIFMLSDCPGVMC--RPSRVRQMFASRACRKSVMIGTALNTGEMKKLVVHMGEIEQPWNCPHGRPTMRHL 182          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Match: pms1 (PMS1 homolog 1, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030616-528])

HSP 1 Score: 135.576 bits (340), Expect = 9.022e-32
Identity = 109/406 (26.85%), Postives = 184/406 (45.32%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLC----------------------------------FLGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKAL--NYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSS---KQFLYVNRRPCELPKVKRLIAECYRVMNKTHN---------PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNVDNSLRSPH 1126
            +K ++ +T + + SSQ + S+   +KELIENSLDA S  +E++L+N+G D IEV DNG GI   +      ++ TSK+   +DL +LET+GFRGEAL S+C                                   LGQ GTTV    +F  LPVRR+ +  + K + +     + + +Y +I   ++I       NK  +     +      + +V G      +  L  +H   Q               +I + G+  +P     S++S+   K F++VN RP     + +L+ + Y   N  H+         P  +++I +P   VDVN+ PDK  ++L N+  V   +++ ++S +       +  +I    S S+  +     TLN    +  S++ PH
Sbjct:    1 MKALSAETVRLLSSSQVITSVLNVVKELIENSLDAGSTSLEVKLENYGLDRIEVRDNGCGIKSADASVMAVKHYTSKISCHEDLEHLETYGFRGEALASICAISEVVVTTKTADDDVSTQYTLDLSGRVISQKPSHLGQ-GTTVCALKLFKNLPVRRQYYSNSKKCKEEVKKVQDLLMAYAVIKPELRIV---FTHNKATVWQKARVSDHRAALMAVLGAASAANL--LPVQHRQEQ--------------PEIAIEGYFPKPNSDLNSTSSNTSDKTFVFVNSRPVHHKDILKLVKQYY--ANAAHSSNESASRRFPVLMMNIIVPASNVDVNLTPDKTQVMLQNKDAVLLAVESVLISLYGSFSVGNDNHTIGDGQSSSMVGQ-----TLN---QISESIKEPH 376          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Match: mlh1 (mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-040426-1600])

HSP 1 Score: 123.635 bits (309), Expect = 3.435e-28
Identity = 100/369 (27.10%), Postives = 170/369 (46.07%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGI--GGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQ---FLYVNRRPCELPKVKRLIAECYRV-MNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTL 1042
            I+R++     RI + + +   A AIKE+IEN LDA S  I++ +K  G  +I++ DNGTGI   + +    R TTSKL+ F+DL ++ T+GFRGEAL S+  +                                 G +GT +S+ ++F+ +P RRK  L +   E+ + +  ++ Y +   G   +   + K  +++   + +    + +NI+ VFG      MIE+  E              K+A     +L G+IS       ++ S K+    L++N R  E   +K+ I   Y   + K  +P   +S+ +    +DVN+ P K  +   ++  +   I+  I S  L S  S+ Y    QTL
Sbjct:    5 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVTVKEGGLKLIQIQDNGTGIRKEDLEIVCERFTTSKLQTFEDLTSISTYGFRGEALASISHVAHVTITTKTADGKCAYRGNYCDGKLKAPPKPCAGNQGTLISVEDLFYNVPTRRKA-LKSPSEEYSRIVEVMSRYAIHNSGKSFT---VKKQGEMVADVKTLPNASVLDNIRVVFGVAVSREMIEVGCEDQ------------KLA----FKLKGYISN------ANYSVKKCIFILFINHRLVESSALKKAIETVYTAYLPKNTHPFLYLSLEIAPHNIDVNVHPTKHEVHFLHEDCIIESIQKHIESKLLGSNSSRTY--FTQTL 345          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Match: mlh3 (mutL homolog 3 [Source:NCBI gene;Acc:103038515])

HSP 1 Score: 77.411 bits (189), Expect = 1.004e-13
Identity = 48/162 (29.63%), Postives = 81/162 (50.00%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG------------------------------------QKGTTVSIRNIFHTLPVRRKQF 430
            I+ ++ +   ++ S  AV S+   ++EL+ NS+DA +  I +++ +  A  ++V+DNG+G+S  + +K  +R  TSK  + +DL++L  +GFRGEA+ S+  L                                       GTTV I N FH +PVRRK+ 
Sbjct:    2 IRTLSKEVQAKLRSGVAVFSLQQCVEELVLNSIDAGATCIAVKI-DIEACKVQVIDNGSGMSREDMEKVGTRYCTSKCSSLEDLDDLRFYGFRGEAIASIASLSTLVEISSQTKASVKTFVKTFNEGRGSGVCEVQDTRPSPGTTVLICNFFHNMPVRRKRM 162          

HSP 2 Score: 58.9214 bits (141), Expect = 4.913e-8
Identity = 56/225 (24.89%), Postives = 94/225 (41.78%), Query Frame = 2
Query: 1397 FRKQYFNDLEVIGQFNKGFIIARLNQD------------LFIIDQHASDEKKQFEKFLNQC-----------EMSSQPLACPKRLQISSGDEEIISENIDLFNK----LGFRFQFKEAELNFRIFMTAVP-----------RRNNLV----LGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTI 1945
            F K   + ++VI Q +K F+   +N              L ++DQHA+ E+ + E  L +             + S  +  P  L+IS  +EEI    + L+      L     F  A+ +  + +  +P           RR        L  E L E ++ ++  G     +P+ V + +AS AC  AI     LS  +   ++  +SS + P+ CAHGRP+I
Sbjct:  915 FTKNMIHSMKVIHQVDKKFLACLINTTDQESTETSQGNLLVLLDQHAAHERVRLEGLLTESYEDDPDTPGKNRLCSSGVIPP--LEISVSEEEI--RLLRLYQSSLRDLALEMSFPPADPS-HVLLERLPTCFIEKENTEQRRGRRTVIKSLSEEYLREHIEFLQSAGRVRSSVPLTVHNVLASQACHGAIKFNDVLSKEECCSLVGSLSSCQLPFQCAHGRPSI 1134          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008212.1 (pep scaffold:Pmarinus_7.0:GL489991:222:4660:1 gene:ENSPMAG00000007425.1 transcript:ENSPMAT00000008212.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 183.726 bits (465), Expect = 4.692e-49
Identity = 87/210 (41.43%), Postives = 135/210 (64.29%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKF-LNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++IS ++NR AEEEL++ F K  F  +EV+GQFN GF++ARL  DLFI+DQHASDEK  +E    +   +  Q L  P +L +++  E ++ EN+D+F K GF F   E A    R+ +T +P +   + G  D+ E++ ++ D  G  C   P RV+  +AS ACR ++MIGT+L+  +M ++L  M  ++ PW+C HGRPT+RHL
Sbjct:  357 RFRAKISPSDNRAAEEELQKKFHKHMFAHMEVVGQFNLGFVVARLGPDLFIVDQHASDEKYNYETLRRDSATLHGQRLIAPLKLPLTAVGELVLMENLDIFRKNGFDFIIDEQAPATQRVRLTTLPVQRGWMFGVSDVEELVFLLSDRPGVMC--RPSRVQQMLASKACRKSVMIGTALNATEMRRLLLHMGEMEQPWSCPHGRPTMRHL 564          

HSP 2 Score: 80.1073 bits (196), Expect = 2.142e-15
Identity = 38/95 (40.00%), Postives = 61/95 (64.21%), Query Frame = 2
Query:  710 LSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            LSG++S+       S++ +QFL+VN RPC+L KV +L+ E Y   N+   P  V++I    + VDVN+ PDKR++LL  +  + AV+KA++ S +
Sbjct:    1 LSGFVSRCDHGAGRSSADRQFLFVNGRPCDLAKVSKLVNEVYHSYNRHQYPFLVLNIVSSTDLVDVNVTPDKRLVLLQEERLLLAVVKATLTSIY 95          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Match: pms1 (PMS1 homolog 1, mismatch repair system component [Source:ZFIN;Acc:ZDB-GENE-030616-528])

HSP 1 Score: 152.14 bits (383), Expect = 1.926e-37
Identity = 99/358 (27.65%), Postives = 170/358 (47.49%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKR---EFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTE---VFKSSNSSKQFLYVNRRPCELPKVKRLIAECYR-----VMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            +K+++ +T + + S+Q   S+ + +KEL+ENSLDA +  +EI+L+N+G D IEV DNG G+   +      R+ TSK+ + +DL ++ T+GFRGE L S+C + +                                 KGTTV I  +F  LPV RKQF    K+   E  K  + + +Y +I   ++ S   +  NK V+     +      +    G   +  MI                 +   A+  ++ +SG++ +P     +  S++S +  L +N RP     + +L+ + YR         TH P F +S+S+P  T+DVN+ PDK  ++L N+  + A +   +L  +
Sbjct:    1 MKQLSAETVRLLSSAQVASSVWSVVKELLENSLDAHATSVEIKLENYGFDKIEVRDNGDGVRSEDTQFMAVRHYTSKISSHEDLEDIATYGFRGEGLGSICAVAEVSITTCTAEDEVSMIYSLDSQGHVTSRKPSHLGKGTTVCITKLFKNLPV-RKQFYSTAKKCKEELKKIEDLLVAYGVIHPDIRFS---LAHNKAVVWQKPRVADQRTALLRCLGTTVMGSMIP----------------VQHQASTMQLSISGFVPKPGADPGITSSTSSDRCLLAINGRPVHYKDLLKLVRQYYRNTSPSSSTHTHYPVFFLSLSIPANTIDVNLTPDKMQVMLHNKEAILAELDEMLLQVY 338          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Match: mlh1 (mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-040426-1600])

HSP 1 Score: 123.25 bits (308), Expect = 1.237e-28
Identity = 95/361 (26.32%), Postives = 168/361 (46.54%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEAL----------------NSLCFL-----------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGIS--ENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRV-MNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRS 1027
            I+R++     RI + + +   A AIKE++EN LDA +  I++ +KN G  +I++ DNGTGI   + +    R TTSKLE F+DL+++ TFGFRGEAL                +S+C                   G +GT ++  ++F+ +  RRK  L +   E  K    ++ Y +   GV  +   + K  +     R + G +  +NI++V+G +    +IE+  E   ++ ++             +++ G+IS      K        L++N R  +   +++ I   Y   + K  +P   IS+ L  + VDVN+ P K  +   ++  +   ++  + S  L S  S+ Y S
Sbjct:    8 IRRLDEAVVNRIAAGEVIQRPANAIKEMMENCLDAKATSIQVTVKNGGLKLIQIQDNGTGIRKEDMEIVCERFTTSKLEKFEDLSSIATFGFRGEALASISHVAHVTITTKTADSMCAYRAMYCDGKLKAPPKPCAGNQGTQITAEDLFYNVATRRKA-LKSASEEHGKITEVVSRYSIHYSGVSFT---LKKQGESTADVRTLPGATTVDNIRAVYGASVARELIEVNYE---DKKLV-------------LKMRGYISNANYSMKKCVF---LLFINHRLVDSTALRKAIEMVYAAYLPKNSHPFLYISLELAPQNVDVNVHPTKHEVHFLHEDSITEAVQQHVESKLLGSNSSRTYFS 345          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 77.0258 bits (188), Expect = 2.909e-14
Identity = 81/366 (22.13%), Postives = 150/366 (40.98%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG------------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRR---PCELPKVKRLIAECYRVMNK---THNPT--------------FVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASI 982
            ++ +  +   R+ S  A+ + +  ++EL+ NSLDA +  +  RL +      +V+DNG GI+ ++     +R  TSK     DL NL  +G+RGEAL S+  +                                       GTTV++ N F+ LPVRRK     L  E++K    I +  L+   V  +  K +    V +  +    +      +FG+ +   + E+  +                   EK +++G+I +        N + QF+YVN R     +L K+  ++ +   ++ K     NP+              FV++I+ P    D+ ++P K ++   +   V   ++ S+
Sbjct:    2 LQELPPEVQARLRSGVALSTASQCVEELLLNSLDAGASCVAARL-HMDDFRFQVVDNGNGITSNDLQVLGNRYFTSKCHKIKDLENLRYYGYRGEALASIASVSSVVEITSRATSSSRTYTKVIQDMQSVIVHEAEKIRPSHGTTVTVHNFFYNLPVRRKCIPPIL--EYEKIRQKIEAIALVHHQVSFT-LKNEYTGTVSVQCQRTNSMLSRFGQIFGETKAQRLSEINYQS------------------EKFQIAGYIGREGH----HNKNLQFIYVNGRLVLKTKLHKLVNILLKKLSIICKQKICQNPSKKEGSLRNSELHGIFVLNITCPLSDYDICLDPMKTLIEFQDWENVLGCVEMSV 341          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 76.2554 bits (186), Expect = 4.719e-14
Identity = 81/366 (22.13%), Postives = 150/366 (40.98%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG------------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRR---PCELPKVKRLIAECYRVMNK---THNPT--------------FVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASI 982
            ++ +  +   R+ S  A+ + +  ++EL+ NSLDA +  +  RL +      +V+DNG GI+ ++     +R  TSK     DL NL  +G+RGEAL S+  +                                       GTTV++ N F+ LPVRRK     L  E++K    I +  L+   V  +  K +    V +  +    +      +FG+ +   + E+  +                   EK +++G+I +        N + QF+YVN R     +L K+  ++ +   ++ K     NP+              FV++I+ P    D+ ++P K ++   +   V   ++ S+
Sbjct:    2 LQELPPEVQARLRSGVALSTASQCVEELLLNSLDAGASCVAARL-HMDDFRFQVVDNGNGITSNDLQVLGNRYFTSKCHKIKDLENLRYYGYRGEALASIASVSSVVEITSRATSSSRTYTKVIQDMQSVIVHEAEKIRPSHGTTVTVHNFFYNLPVRRKCIPPIL--EYEKIRQKIEAIALVHHQVSFT-LKNEYTGTVSVQCQRTNSMLSRFGQIFGETKAQRLSEINYQS------------------EKFQIAGYIGREGH----HNKNLQFIYVNGRLVLKTKLHKLVNILLKKLSIICKQKICQNPSKKEGSLRNSELHGIFVLNITCPLSDYDICLDPMKTLIEFQDWENVLGCVEMSV 341          

HSP 2 Score: 51.9878 bits (123), Expect = 1.330e-6
Identity = 46/225 (20.44%), Postives = 87/225 (38.67%), Query Frame = 2
Query: 1397 FRKQYFNDLEVIGQFNKGFIIARLNQD-----------LFIIDQHASDEKKQFEKF-------------LNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVP------------RRNNLVLGTEDLHEMLQII---KDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            F K  F  L+VI Q +K FI+                 L ++DQHA+ E+ + E+              + +  M +  +  P  L+ +  +  +I        + G +  F    +   + +T VP            R    + GT     + + +   +  G     +P  +   + S AC  A+  G  LS+ +   +++ ++  + P+ CAHGRP +  L
Sbjct: 1157 FTKDMFASLQVIQQVDKKFIVCLCTDKGPERQKGNLNILILVDQHAAHERVRLEQLTAELFEVSEDSADIGKRVMRTSLVVPPMALEFNCHEISLIRSYQGHLERHGLQLAFPAEAV---VHVTGVPACLVERETGEARRGRPPITGTILEELIREELELLQQTGGARGTLPRAIIRVLNSQACHGAVKFGDKLSWDECASLMRDLAKCQLPFQCAHGRPAMMPL 1378          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Yeast
Match: PMS1 (ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [Source:SGD;Acc:S000005026])

HSP 1 Score: 195.282 bits (495), Expect = 2.099e-51
Identity = 115/352 (32.67%), Postives = 184/352 (52.27%), Query Frame = 2
Query:   44 LMNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ--------------------------------KGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDK--NKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNIN---QDILDEF-NISKVANLE-KIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASI 982
            +  I +IN     RI S Q +  +  A+KEL++NS+DA++ +IEI  K++G + IE  DNG GI P  ++    ++ TSK+  F D+  ++T GFRGEAL+SLC + +                                KGTTV +  +FH LPVR+K+F    KR+F K L  I  Y +I   ++ S   I     K +ILST     + +NI SVFG   + G+ E+    ++N     +L ++ +     +L+ KI + G+ISQ +     ++  +QF+YVN+RP E   + +   E Y+  N    P   +++ LP   +DVN+ PDKR++LL N+  V  + K ++
Sbjct:    1 MTQIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIEIIFKDYGLESIECSDNGDGIDPSNYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITTTSPPKADKLEYDMVGHITSKTTTSRNKGTTVLVSQLFHNLPVRQKEFSKTFKRQFTKCLTVIQGYAIINAAIKFSVWNITPKGKKNLILSTMRNSSMRKNISSVFGAGGMRGLEEVDLVLDLNPFKNRMLGKYTDDPDFLDLDYKIRVKGYISQNSFGCGRNSKDRQFIYVNKRPVEYSTLLKCCNEVYKTFNNVQFPAVFLNLELPMSLIDVNVTPDKRVILLHNERAVIDIFKTTL 352          

HSP 2 Score: 140.584 bits (353), Expect = 3.419e-34
Identity = 79/211 (37.44%), Postives = 115/211 (54.50%), Query Frame = 2
Query: 1373 AEEELKRIFRKQYFNDLEVIGQFNKGFIIARLN----QDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCI--VMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA**TWSS 1984
             E+ L     K  F  +EV+GQFN GFII         DLFI+DQHASDEK  FE         SQ L  P+ +++S  DE ++ +N+ +F K GF+ +  +E E   R+ + ++P     +    D +E++ +IK+ G      +   ++RS  A  ACRS+IMIG  L+   M +++  +S L  PW C HGRPT+RHL  L    WSS
Sbjct:  658 GEKYLTLTVSKNDFKKMEVVGQFNLGFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVFKSQKLIIPQPVELSVIDELVVLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKEDGGLRRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLSELDKPWNCPHGRPTMRHLMELR--DWSS 866          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Yeast
Match: MLH1 (Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer [Source:SGD;Acc:S000004777])

HSP 1 Score: 117.857 bits (294), Expect = 3.299e-27
Identity = 89/343 (25.95%), Postives = 160/343 (46.65%), Query Frame = 2
Query:   47 MNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKI-DKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYR-VMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVI 970
            + IK ++     +I + + ++S   A+KE++ENS+DA++  I+I +K  G  ++++ DNG+GI+  +      R TTSKL+ F+DL+ ++T+GFRGEAL S+  +                                 G+ GTT+ + ++F  +P R +  L +   E+ K L+ +  Y +  + +  SC K  D N    LS +    + + I++VF ++  + +I               F+ISKV +L    + G +      F S  S     ++N R      ++R +   Y   + K + P   + I +    VDVN+ P KR +   +Q E+   I
Sbjct:    3 LRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRA-LRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYS--LSVKPSYTVQDRIRTVFNKSVASNLI--------------TFHISKVEDLNLESVDGKVCNLN--FISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKI 326          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Yeast
Match: MLH2 (Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p [Source:SGD;Acc:S000004025])

HSP 1 Score: 73.1738 bits (178), Expect = 2.237e-13
Identity = 88/373 (23.59%), Postives = 158/373 (42.36%), Query Frame = 2
Query:   47 MNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGK--IEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEA---LNSLC---------------FLGQK---------------------GTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQ--ISCCKIDKNKQV------------ILSTRGIGGISENIKSVFGQNQLNGMIE--LTTEHNINQDILDEFNI--SKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCEL-----PKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIK 973
            M I +++ ++  +I SS  +    AA++EL++NS+D+ + K  I++     G + I V D+G+G+   +        TTSK+ +  D++ L T GFRGEA   L++LC                +G+K                     GTTV +R +   L  R  +     ++ FD+ +  I  Y LI   ++   S   + KN  +            I   R +  ++   K V     LN ++E     +  IN D++    +  S V N+++             FK       FL VN R   L       + +L++  YR  +      + I+++   + +DVNIEP+K  +++ +   +F  I+
Sbjct:    1 MTIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVDIIDRPSMCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLVDSKGGITNGKRYKVSCPVGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLIHRNIRFYFSLVSLQKNGAIERKQMQETLDPKISRARSLSLLARLKKPV----PLNFIVEENFVIDEKINLDLILPRMVPESDVINIKR------------RFK-------FLSVNERALSLNLETGKTISKLLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIE 350          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Yeast
Match: MLH3 (Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability [Source:SGD;Acc:S000006085])

HSP 1 Score: 71.2478 bits (173), Expect = 7.947e-13
Identity = 34/103 (33.01%), Postives = 67/103 (65.05%), Query Frame = 2
Query:   50 NIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIE--IRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSL 352
            +I+++++  S+R+ S    VS+A+A++E+++NS+DA +  I+  I L N       V D+G G++  + +   ++N TSK+   +DL  ++T+G+RG+AL S+
Sbjct:    4 HIRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTIDVMIDLPNLS---FAVYDDGIGLTRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYSI 103          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Match: EDO34014 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQJ8])

HSP 1 Score: 251.521 bits (641), Expect = 4.895e-70
Identity = 129/347 (37.18%), Postives = 205/347 (59.08%), Query Frame = 2
Query:   62 INTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLE--KIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            I+ ++  +ICS Q V+++A A+KEL+ENSLDA +  +++RLK  G+  IEV DNG G+ P  F+  T ++ TSKL++F DL+ +ETFGFRGEAL+SLC L                                  ++GT V++ N+F TLPVR K+FL N+K+EF K ++ +  YCLI  G +I+C   +   +  ++ST G   I +NI +VFG  Q+  ++         +D   E N+S V+N E     ++G+IS+       S+S +QF ++N+RPC+LPKV R+++E Y + N+   P  ++ ISL ++ VDVN+ PDKR + L  ++ + A ++ S++  F
Sbjct:   19 IDRKSVHQICSGQVVLNLATAMKELLENSLDAGATSVDVRLKEHGSHSIEVSDNGAGVEPQNFEALTLKHYTSKLKDFSDLSAVETFGFRGEALSSLCALSDLSITTRHISQTAGTKLDYDHNGKLKSKLPCAREQGTMVTVLNLFSTLPVRHKEFLRNIKKEFVKLVHVLQGYCLISAGTRITCTNHVSGRRSTVVSTHGSSQIKDNITAVFGPKQVQSLLPFKQLQPSEEDC-TELNLSVVSNSETNPFTITGFISKADHGSGRSSSDRQFFFINKRPCDLPKVSRVVSEVYHMYNRHQFPFVMLDISLKRDAVDVNVTPDKRQVFLQQETLLLATLRTSLIKMF 364          

HSP 2 Score: 192.2 bits (487), Expect = 2.221e-50
Identity = 93/217 (42.86%), Postives = 139/217 (64.06%), Query Frame = 2
Query: 1328 NGK---YKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            NGK   ++++IS  NN  AEEEL R  ++  F  +E++GQFN GFI+A+L+ DLFIIDQHASDEK  FE       + +Q L  P++L++++ +E I+ +N+++F K GF FQ   +A    ++ + +VP   N   G ED+ E++ ++ D     +  P RVR   AS ACR +IM+GT+LS+ QM  I++ M  +K PW C HGRPT+RH+  LA
Sbjct:  553 NGKVRIFRAKISPENNSAAEEELTRNIQRGSFARMEIVGQFNLGFILAKLDNDLFIIDQHASDEKYNFEMQQRNTVLRNQRLIIPRKLELTAVNESILLDNLEIFRKNGFEFQIDDDAPATQKVKLVSVPTSKNWTFGVEDVEELIFMLSD-APGILCRPTRVRKMFASRACRMSIMVGTALSHAQMQGIVRHMGEMKHPWNCPHGRPTMRHVVNLA 768          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Match: EDO31419 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXZ4])

HSP 1 Score: 249.21 bits (635), Expect = 3.625e-69
Identity = 129/347 (37.18%), Postives = 204/347 (58.79%), Query Frame = 2
Query:   62 INTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEK--IELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            I+ ++  +ICS Q V+S+A A+KEL+ENSLDA +  +++RLK  G+  IEV DNG G+ P  F+  T ++ TSKL++F DL+ +ETFG+RGEAL+SLC L                                  ++GT V++ N+F TLPVR K+FL N+K+EF K ++ +  YCLI  G +I+C   +   +  ++ST G   I +NI +VFG  Q+  ++         +D   E N+S V+N E     ++G+IS+       S+S +QF ++N+RPC+LPKV R+++E Y + N+   P  ++ ISL ++ VDVN+ PDKR + L  +  + A ++ S++  F
Sbjct:   19 IDRKSVHQICSGQVVLSLATAMKELLENSLDAGATSVDVRLKEHGSHSIEVSDNGAGVEPQNFEALTLKHYTSKLKDFSDLSAVETFGYRGEALSSLCALSDLSITTRHISQTAGTKLDYDHNGKLKSKLPCAREQGTMVTVLNLFSTLPVRHKEFLRNIKKEFVKLVHVLQGYCLISAGTRITCSNHVAGKRSTVVSTHGSLQIKDNITAVFGPKQVQSLLPFKQLQPSEEDCT-ELNLSVVSNSESNPFTITGFISKADHGSGRSSSDRQFFFINKRPCDLPKVSRVVSEVYHMYNRHQFPFVMLDISLKRDAVDVNVTPDKRQVFLQQEKLLLATLRTSLIKMF 364          

HSP 2 Score: 186.422 bits (472), Expect = 1.966e-48
Identity = 95/242 (39.26%), Postives = 145/242 (59.92%), Query Frame = 2
Query: 1247 QNISANFSMKYISLLDTNAENDIT-NAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQF-KEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            + +   FSM+ +     +    IT NA    ++++IS  NN  AEEEL +   K  F  +E++GQFN GFI+A+L+ DLFIIDQHASDEK  FE       + +Q L  P++L++++ +E I+ +N+++F K GF FQ   +A    ++ + +VP   N   G ED+ E++ ++ D     +  P RVR   AS ACR +IM+GT+LS+  M  I+  M  ++ PW C HGRPT+RH+  LA
Sbjct:  539 KTVEVEFSMEKLRSRSHSLNTSITQNAEVRIFRAKISPENNSAAEEELTKNIEKGSFARMEIVGQFNLGFILAKLDNDLFIIDQHASDEKYNFEMQQRNTVLRNQRLIIPRKLELTAVNESILLDNLEIFRKNGFEFQIDDDAPATQKVKLVSVPTSKNWTFGVEDVEELIFMLSD-APGILCRPTRVRKMFASRACRMSIMVGTALSHAHMQGIVGHMGQMEHPWNCPHGRPTMRHVVNLA 779          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Match: EDO49003 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHM2])

HSP 1 Score: 146.362 bits (368), Expect = 3.731e-38
Identity = 99/349 (28.37%), Postives = 170/349 (48.71%), Query Frame = 2
Query:   74 TSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGN--LKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTE---VFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKT---HNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFL 997
            T  RI SSQ + S+++A+KEL+EN+LDA +  IE++L+ +G + IEV DNGTGI   +      R+ TSK+  F +L++L ++GFRGEAL SLC +                                    GT V+  N+F  LPVR++   GN   K E  K    I ++ LI   V+++   +  NK +I        + + +  + G N ++ M E+  + +                   + + G++ +P     V   S   + F+YVN+RP  L ++ +++ E Y  ++ T    +P   +SI +P   VDVN+EP+K  +LL  +  +  +++ S+   ++
Sbjct:   11 TVHRIASSQVITSVSSAVKELLENALDAGANSIEVKLEEYGLEKIEVRDNGTGIPQDDAQFMAQRHYTSKITTFHNLDSLASYGFRGEALCSLCAVSNVSVMTKTNNEEVGMCYTLDQHGRISATKPLPLTTGTVVTACNLFKNLPVRKQFSRGNKKCKDELKKVEELIMAFGLIHPSVRLT---LRHNKSIIWQKNKCEDLKKALTGIIGANAMSSMEEIIVKDDQT----------------GLRIEGFVPKPGSDPNVTSRSMGDRSFVYVNKRPVVLKEIAQVVREFYLKIHPTISNRHPVAFLSIEVPPCAVDVNLEPNKSRVLLTEKDIIIDLLRNSLEELYV 340          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Match: EDO39827 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8W4])

HSP 1 Score: 99.7525 bits (247), Expect = 3.668e-21
Identity = 78/342 (22.81%), Postives = 155/342 (45.32%), Query Frame = 2
Query:   35 LINLMNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL----------------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQ---FLYVNRRPCELPKVKRLIAECYRV-MNKTHNPTFVISISLPKETVDVNIEPDKR 928
            + ++ +I++++     RI + + +   A A+KE+IEN LDA S  I + +K+ G  ++++ DNG GI   +      R TTSKL  F+DL+++ T+GFRGEAL S+  +                                        G KGT +++ ++F+ +  RRK  L +   E+ K ++ ++ Y +   GV  +  K  +    + +T     + +NI++++G      ++++  ++            S++       + G I+       ++ S K+    L++N R  +   ++R +   Y   + K  +P   +S+ +    VDVN+ P K 
Sbjct:    1 MADIPSIRKLDETVVNRIAAGEVIQRPANALKEMIENCLDAKSTSITVTVKSGGLKLLQIQDNGCGIRKEDMHIVCERFTTSKLSKFEDLSSISTYGFRGEALASISHVAHVTITTKTAHSSCAYKASYSDGKLVPPRPGLPAEPKPCAGNKGTQITVEDLFYNVATRRKA-LKSPGEEYSKVVDVVSKYSIHNTGVAFTLKKQGEATADVRTT-STASLHDNIRAIYGTAVARELVDIDCDN------------SRLG----FYMKGCITN------ANYSVKKLIFLLFINHRLVDSTALRRSLETVYEAYLPKGTHPFVYMSLQITPSNVDVNVHPTKH 318          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Match: EDO46831 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP06])

HSP 1 Score: 83.1889 bits (204), Expect = 8.566e-17
Identity = 87/353 (24.65%), Postives = 140/353 (39.66%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSL-----------------------------------CF-LGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRL----------IAECYRVMNKTHNPT-------------FVISISLPKETVDVNIEPDKRIL 934
            I+ ++T     + S  A+ ++  AI EL+ N+LDA +  I + + +  +  ++V DNG+GI+    +    R  TSK  +  DL  L ++GFRGEAL S+                                   CF     GTTV+I +IF  LPVRRK     L  +F++    + S  LI   V       D   Q  L TR    ++     +FG  +   + ++ +EH         F +S    +E                  N + QF+Y+N R     K+ +L          I +    M++   P              F+I+I+ P    DV +EP K ++
Sbjct:    2 IRHLDTGIRSHLRSGVAISTLTQAIDELVTNALDAGASCINVHV-DIPSFRVQVSDNGSGITKDNLEILGQRYCTSKCHSLSDLRKLSSYGFRGEALASIRDICGVLEIVTKHSSSYKTYCKLFRSGKPLTVTQSCFPRSNTGTTVTIHDIFSNLPVRRKLLSSVL--DFERVRQRLLSIALIHPEVSFILFN-DATFQKCLQTRKCLSVTSTFSQLFGNLKARSLKDVFSEHK-------HFKVSGHIGIE---------------PHHNKNLQFVYINSRLLLKTKIHKLLNSMLSKSSFIKQLPSNMSENDVPMRSPPQRSSEKNAIFIINITCPLMVYDVILEPSKTLV 328          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Medaka
Match: pms2 (PMS1 homolog 2, mismatch repair system component [Source:NCBI gene;Acc:101169320])

HSP 1 Score: 233.417 bits (594), Expect = 3.281e-63
Identity = 122/350 (34.86%), Postives = 209/350 (59.71%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCC-KIDKNKQV-ILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKI-ELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCF 994
            IK I+  +  +ICS Q V+S+A A+KEL+ENS+DA +  I+I+L++ G + IEV DNG G+    F+  T ++ TSKL +F DL ++ETFGFRGEAL+SLC L                                  Q+GTTV+++ +FHTLPVR K+F  N+K+E+ K ++ + +YC+I  GV+++C  +  + K+V +LST G   + ENI ++FG  QL  ++    + + ++++L+E+ + +    E++  ++G+IS+       S + +QF ++N RPC+  K+ +++ E Y   N+   P   ++I++  E VDVN+ PDKR + L  +  + A +K S+++ +
Sbjct:   13 IKAIDKHSVHQICSGQVVLSLATAVKELVENSVDAGATNIDIKLRDCGVEQIEVSDNGKGVKEANFEGLTLKHHTSKLRDFSDLIHVETFGFRGEALSSLCALSDLSVITCHESSQVGTKLVFDHKGQLVQKSPHPRQQGTTVALQQLFHTLPVRHKEFQRNIKKEYAKMIHVLQAYCIISAGVRLTCSNQSGRGKRVTVLSTSGSQSMRENIGAIFGPKQLQSLLPFQ-QTSPSENVLEEYGLKEAELPEQLFSIAGFISRSDHGVGRSATDRQFFFINNRPCDPLKITKVVNEVYHSYNRHQYPFVALNIAVASECVDVNVTPDKRQIFLQEEKVLLATLKTSLINMY 361          

HSP 2 Score: 182.57 bits (462), Expect = 1.186e-46
Identity = 86/209 (41.15%), Postives = 133/209 (63.64%), Query Frame = 2
Query: 1334 KYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKE-AELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDY-GSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHL 1954
            +++++I+   N++AEEEL++   K  F ++++IGQFN GFII +LN D+FIIDQHA+DEK  FE       +  Q L  P++L +++  E ++ ENI++F K GF F   E A++  R+ + ++P   N   G  D+ E++ ++ D  G  C   P RVR   AS ACR ++MIGT+LS  +M K++  M  ++ PW C HGRPT+RHL
Sbjct:  613 RFRAKINPGENQSAEEELRKEISKDMFKEMKIIGQFNLGFIITKLNSDIFIIDQHATDEKYNFEMLQQHTLLQGQKLIAPQKLHLTAISENVLMENIEVFRKNGFEFLIDEDAQVMERVRLVSLPTSKNWTFGPADIEELIFMLSDSPGVMC--RPSRVRQMFASRACRKSVMIGTALSVSEMKKLVVHMGEIEHPWNCPHGRPTMRHL 819          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Medaka
Match: pms1 (PMS1 homolog 1, mismatch repair system component [Source:NCBI gene;Acc:101157983])

HSP 1 Score: 138.658 bits (348), Expect = 1.530e-32
Identity = 102/365 (27.95%), Postives = 180/365 (49.32%), Query Frame = 2
Query:   17 FYVLN*LINLMNI----KRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGQ---------------------------------KGTTVSIRNIFHTLPVRRKQFLGN--LKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSS---KQFLYVNRRPCELPKVKRLIAE--CYRVMN---KTHNPTFVISISLPKETVDVNIEPDK-RILLLDNQSEVFAV 967
             Y LN L +L  I    K +   + + + SSQ + S+   +KEL+ENSLDA +  I+++L+NFG D IEV DNG G+   +      R+ TSK+ + +DL +LET+GFRGEAL S+C + +                                 +GT+V+   +F  LPVRR+ +      K E  K  + + +Y +I   +++S   +  NK V+     +      + +  G + +  +++   +    + ILD                G++ +P   + S++SS   K FLYVN RP +L ++ +L+ +  C + +    +   P  +++I++   ++DVN+ PDK ++LL D ++ + AV
Sbjct:   67 LYPLNGLQHLKRIFGAMKLLPPDSVRLLSSSQVITSVVNVVKELLENSLDAGASSIDVKLENFGLDRIEVRDNGHGVKAADASVMAVRHFTSKICSHEDLEHLETYGFRGEALGSICAVAELIVTTKTEEDDISTQYTLDPTGKIVAQKPSHLGQGTSVTALKLFKNLPVRRQYYTSTKKCKEELKKVQDLLITYAIIKPELRLS---LVHNKVVVWQKTKVADNRSALLATLGPSVVANLLQCHQQQEEPEIILD----------------GFLPKPGADYSSTSSSAPDKTFLYVNNRPVQLKEIMKLLRQHYCAQYLEDAVRNRYPILMLNITVSPSSLDVNLTPDKSQVLLHDKEAVLTAV 412          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Medaka
Match: mlh1 (mutL homolog 1 [Source:NCBI gene;Acc:111948792])

HSP 1 Score: 117.087 bits (292), Expect = 3.644e-26
Identity = 94/370 (25.41%), Postives = 172/370 (46.49%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGI--GGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQF---LYVNRRPCELPKVKRLIAECYRVM--NKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTL 1042
            I+R++     RI + + +   A A+KE+IEN LDA +  I++ +K+ G  ++++ DNGTGI   + +    R TTSKL+ F+DL+++ T+GFRGEAL S+  +                                 G +GT + + ++F+ +  RRK  L +   E+ + +  ++ Y +   G  ++   + K  + +   R +    + +NI+SVFG      +I++  E              K+A     ++SG+IS       ++ S K++   L++N R  E   +K+ +   Y      KTH P   +S+ +  + VDVN+ P K  +   ++  V   ++  I    L  G++       QTL
Sbjct:    5 IRRLDETVVNRIAAGEVIQRPANAVKEMIENCLDAKATNIQVTVKDGGLKLLQIQDNGTGIRKDDMEIVCERFTTSKLQTFEDLSSIATYGFRGEALASISHVAHVTITTKTADAKCAYRASYRDGKPRGPPKPCAGNQGTQIMVEDLFYNVSTRRKA-LKSPADEYSRIVEVVSRYAIHNSGKSLT---VKKQGETVADVRTLPNASVVDNIRSVFGNAVSRELIQVGCED------------PKLA----FKMSGYISN------ANYSVKKYVFILFINHRLVESSALKKAVETVYAAYLPKKTH-PFLYLSLEISPQNVDVNVHPTKHEVHFLHEDSVIESVQKHIDGKLL--GFNSSRTFFTQTL 345          
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Medaka
Match: mlh3 (mutL homolog 3 [Source:NCBI gene;Acc:101166595])

HSP 1 Score: 71.2478 bits (173), Expect = 8.651e-12
Identity = 46/169 (27.22%), Postives = 81/169 (47.93%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG------------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKRE 451
            IK +  +   ++ S  A+ S+   ++EL+ NS+DA +  + +R+ +  A  ++V+DNG G++     +  +R  TSK  + +DL+N+++ GFRGEAL S+  +                                       GTTV + N FH +PVRR++    L+ E
Sbjct:   15 IKLLPPEVQGQLRSGVAIPSLQQCVEELVLNSIDAGATCVGVRM-DLEAFKVQVIDNGAGMNTENMQRVGNRYHTSKCGSLEDLDNVKSHGFRGEALASIVSMATLVEISSRSRASAKTLVKLFKDGRGVDVFEAETVRPSAGTTVIVCNFFHNMPVRRRRLDAVLEGE 182          

HSP 2 Score: 61.2326 bits (147), Expect = 1.020e-8
Identity = 58/230 (25.22%), Postives = 95/230 (41.30%), Query Frame = 2
Query: 1403 KQYFNDLEVIGQFNKGFIIARLNQD--------------LFIIDQHASDEKKQFEKFLNQC-----EMSSQPLACPKR----LQISSGDEEI--ISENIDLFNKLGFRFQFKEAELNFRIFMTAVP------RRNNLVLG---------TEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPT------IRHL 1954
            K   + ++V+ Q +K F+   +N                L ++DQHA+ E+ + E  +        E+  +   C       L+IS  +EE+  +S        LG    F E +    IF+  VP        N L  G          E L E ++++   G     +PI V   +AS AC  A+    +L+  +   ++  +SS + P+ CAHGRP+      IRHL
Sbjct:  869 KAMIHSMKVVDQVDKKFLACLINTREEELASDGDTEGNLLVLVDQHAAHERVRLENLITDSYEDNPEIFGEKWLCSSTIVPPLEISVTEEELRLLSSCRSQLRSLGLEVTFSETQ-RPSIFVGKVPLCFLEKETNELKRGRPSIIKTIVEEYLQEQIELLLSTGRVKRTLPITVLKVLASLACHGAVKFNDTLNRDECHSLVASLSSCQLPFQCAHGRPSIAPLVDIRHL 1097          
BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Match: SMESG000004803.1 (SMESG000004803.1)

HSP 1 Score: 1248.03 bits (3228), Expect = 0.000e+0
Identity = 615/651 (94.47%), Postives = 618/651 (94.93%), Query Frame = 2
Query:  113 MAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG---------------------------------QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNVDNSLRSPHVRKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 1966
            MAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLG                                 QKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKT+NPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNV+NSLRSPH+RKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA
Sbjct:    1 MAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFLGDVEIHTNSLTTSIGSLLKFDQYGKIISLNSVARQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECYRVMNKTNNPTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSVNVENSLRSPHLRKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMKLPLVVSQNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRIFRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA 651          
BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Match: SMESG000011828.1 (SMESG000011828.1)

HSP 1 Score: 116.701 bits (291), Expect = 3.877e-26
Identity = 92/329 (27.96%), Postives = 154/329 (46.81%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCFL---------------------------------GQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLI-CEGVQISCCKIDKNKQVILSTRGIG--GISENIKSVFGQNQLNGMIELTTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQF-LYVNRRPCELPKVKRLIAECY-RVMNKTHNPTFVISISLPKETVDVNIEPDK 925
            IK+++     +I + + +   A AIKEL+ENSLDA+S +I I +K  G  +I++ DNG+GI   +F     + TTSKL+ F DL  + TFGFRGEAL S+  +                                 G  GT V + ++F+ +P+R+   L + + E+ K +  +++Y ++      I+  KID N       R +    I + +  +FG      ++ +    ++  D LD F            LSG IS+P      +N   +F L++N+R      +K+ I   Y  ++ K   P   + + LP + +DVN+ P K
Sbjct:    7 IKKLDDNVINKIAAGEIIQRPANAIKELLENSLDANSTQIIISVKQGGLGVIQIQDNGSGICKEDFPILCEKFTTSKLQEFHDLLTISTFGFRGEALASVTHVAHVQITSKTIDSPCAYKAEFSNSKLLKPPKPCAGNTGTIVRVEDLFYNIPIRKAS-LKSAREEYSKIIEVVSNYAILNAHKCSITLKKIDDNATSSPDVRIVAETSIEDCVVELFGGELSKQLLTI----DLKNDKLDFF------------LSGRISKPN----YNNRKFRFILFINQRLVHCDLLKKSIENVYGNLLPKHTYPFAFLHLQLPSKNIDVNVHPTK 314          
BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Match: SMESG000066771.1 (SMESG000066771.1)

HSP 1 Score: 115.161 bits (287), Expect = 7.100e-26
Identity = 114/389 (29.31%), Postives = 181/389 (46.53%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCF-------------------------LGQ----------KGTTVSIRNIFHTLPVRRKQF--LGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIEL----TTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECY-RVMNKTHN--PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLN 1087
            +K++N  T + I SS  + S+   IKEL+ENS+DA + +I I LK FG D IEV+D+G G    +      R+ TSK+  F D+  + TFGFRGE L+S+C                          +GQ          +GTT+++ NIFH LPVR + +  L  L++        +    L    + I   K+  +  V+L+        E I  V G ++     EL    TTE N ++  L+ F  S V   +K+ L+                  +L+VN RP E+  + + +   Y +  N+  N  P+ V+ ++LPK  VDVNI+P+KR + L N  ++   I+ +     L+  Y     ++N+ L  +     NN Y +N
Sbjct:    1 MKKLNDSTVKLISSSYVISSVECVIKELVENSIDACASRIFINLKRFGLDKIEVIDDGCGFD--DVPLICQRHCTSKISEFTDIETINTFGFRGEVLSSICAISNLSILSKNTADNSALGKNWVFDKMGQIMAHSAVTCKQGTTITVSNIFHNLPVRCQMYNSLFVLQKTLKSITTNLHHLYLSRRNIHI---KLLNDNNVVLNLPMTSSRKEAIPFVIGASKFKYFHELLKSETTEDN-HEMSLNLFVPSSVD--DKLGLT----------HCDYKENCYLFVNDRPAEVSFLFKAVRTTYMKFTNQNLNRYPSMVLYLTLPKSWVDVNIDPEKRKIKLSNTLQITDFIQTN-----LRKFYESLPNNVNEELPVA-----NNGYNIN 361          
BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Match: SMESG000066771.1 (SMESG000066771.1)

HSP 1 Score: 115.161 bits (287), Expect = 1.292e-25
Identity = 114/389 (29.31%), Postives = 181/389 (46.53%), Query Frame = 2
Query:   53 IKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFGADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALNSLCF-------------------------LGQ----------KGTTVSIRNIFHTLPVRRKQF--LGNLKREFDKALNYITSYCLICEGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIEL----TTEHNINQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPCELPKVKRLIAECY-RVMNKTHN--PTFVISISLPKETVDVNIEPDKRILLLDNQSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLN 1087
            +K++N  T + I SS  + S+   IKEL+ENS+DA + +I I LK FG D IEV+D+G G    +      R+ TSK+  F D+  + TFGFRGE L+S+C                          +GQ          +GTT+++ NIFH LPVR + +  L  L++        +    L    + I   K+  +  V+L+        E I  V G ++     EL    TTE N ++  L+ F  S V   +K+ L+                  +L+VN RP E+  + + +   Y +  N+  N  P+ V+ ++LPK  VDVNI+P+KR + L N  ++   I+ +     L+  Y     ++N+ L  +     NN Y +N
Sbjct:    1 MKKLNDSTVKLISSSYVISSVECVIKELVENSIDACASRIFINLKRFGLDKIEVIDDGCGFD--DVPLICQRHCTSKISEFTDIETINTFGFRGEVLSSICAISNLSILSKNTADNSALGKNWVFDKMGQIMAHSAVTCKQGTTITVSNIFHNLPVRCQMYNSLFVLQKTLKSITTNLHHLYLSRRNIHI---KLLNDNNVVLNLPMTSSRKEAIPFVIGASKFKYFHELLKSETTEDN-HEMSLNLFVPSSVD--DKLGLT----------HCDYKENCYLFVNDRPAEVSFLFKAVRTTYMKFTNQNLNRYPSMVLYLTLPKSWVDVNIDPEKRKIKLSNTLQITDFIQTN-----LRKFYESLPNNVNEELPVA-----NNGYNIN 361          
BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Match: SMESG000007016.1 (SMESG000007016.1)

HSP 1 Score: 53.9138 bits (128), Expect = 1.777e-7
Identity = 50/187 (26.74%), Postives = 84/187 (44.92%), Query Frame = 2
Query: 1424 EVIGQFNKGFIIARL-----NQDLFIIDQHASDEKKQFEKFLNQCEMSSQPLACPKRLQISSGDEEIISENIDLFNKL--GFRFQFKEAELNFR-IFMTAVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIA-----SNACRSAIMIGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTI 1945
             +IGQF   FI A+      N  +F IDQHA+ E+   E    +C+       C K+  + +  +    E  D  N +   F F  +  + +F   ++T  P    L+L  E L      + D  S+ +  P + +  I      S AC +AI  G  L+  +M +++  ++    P+ CAHGRP++
Sbjct:   20 HIIGQFENKFIFAKSSLKTGNLLIFAIDQHAAHERILLEDLQRKCKTKH----CLKQCHLVTPVKLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPL---LLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSV 199          
The following BLAST results are available for this feature:
BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PMS27.987e-6938.57PMS1 homolog 2, mismatch repair system component [... [more]
PMS21.406e-4640.71PMS1 homolog 2, mismatch repair system component [... [more]
PMS21.639e-4437.08PMS1 homolog 2, mismatch repair system component [... [more]
PMS21.639e-4437.08PMS1 homolog 2, mismatch repair system component [... [more]
PMS22.085e-4437.08PMS1 homolog 2, mismatch repair system component [... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pms-28.784e-5432.52PMS (Post Meiotic Segregation) family [Source:Uni... [more]
mlh-12.232e-1823.87MLH (MutL Homolog) family [Source:UniProtKB/TrEMB... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Pms22.052e-5134.18gene:FBgn0011660 transcript:FBtr0087388[more]
Mlh16.598e-2826.89gene:FBgn0011659 transcript:FBtr0088790[more]
Mlh13.156e-2726.69gene:FBgn0011659 transcript:FBtr0331379[more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pms26.064e-6434.86PMS1 homolog 2, mismatch repair system component [... [more]
pms22.058e-6234.86PMS1 homolog 2, mismatch repair system component [... [more]
pms22.322e-4338.94PMS1 homolog 2, mismatch repair system component [... [more]
pms13.656e-4030.87PMS1 homolog 1, mismatch repair system component [... [more]
pms13.721e-4030.87PMS1 homolog 1, mismatch repair system component [... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prph26.362e-6237.99peripherin 2 (retinal degeneration, slow) [Source:... [more]
prph26.433e-6236.93peripherin 2 (retinal degeneration, slow) [Source:... [more]
prph21.011e-6137.99peripherin 2 (retinal degeneration, slow) [Source:... [more]
prph21.209e-6137.99peripherin 2 (retinal degeneration, slow) [Source:... [more]
prph21.258e-6137.99peripherin 2 (retinal degeneration, slow) [Source:... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pms25.862e-6938.00PMS1 homolog2, mismatch repair system component [S... [more]
Pms22.488e-4841.59PMS1 homolog2, mismatch repair system component [S... [more]
Pms12.157e-3329.25PMS1 homolog 1, mismatch repair system component [... [more]
Pms15.320e-3329.33PMS1 homolog 1, mismatch repair system component [... [more]
Mlh15.384e-2826.83mutL homolog 1 [Source:MGI Symbol;Acc:MGI:101938][more]
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BLAST of DNA mismatch repair protein PMS2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|F1NQJ3|PMS2_CHICK1.021e-6838.29Mismatch repair endonuclease PMS2 OS=Gallus gallus... [more]
sp|P54278|PMS2_HUMAN3.835e-6838.57Mismatch repair endonuclease PMS2 OS=Homo sapiens ... [more]
sp|P54279|PMS2_MOUSE8.159e-5534.18Mismatch repair endonuclease PMS2 OS=Mus musculus ... [more]
sp|Q941I6|PMS1_ARATH2.653e-5433.04DNA mismatch repair protein PMS1 OS=Arabidopsis th... [more]
sp|Q0STR3|MUTL_CLOPS2.253e-5326.59DNA mismatch repair protein MutL OS=Clostridium pe... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2LJX31.146e-13135.34Uncharacterized protein OS=Opisthorchis felineus O... [more]
G7Y8X14.952e-12834.56DNA mismatch repair protein PMS2 OS=Clonorchis sin... [more]
A0A504Z4G01.013e-12334.25Mismatch repair endonuclease PMS2 OS=Fasciola giga... [more]
W6USS91.834e-12233.61Mismatch repair endonuclease PMS2 OS=Echinococcus ... [more]
A0A4S2LJN28.700e-11934.81Uncharacterized protein OS=Opisthorchis felineus O... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pms24.166e-6736.54PMS1 homolog 2, mismatch repair system component [... [more]
ENSAMXT00000030240.11.345e-4240.98pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
pms19.022e-3226.85PMS1 homolog 1, mismatch repair system component [... [more]
mlh13.435e-2827.10mutL homolog 1, colon cancer, nonpolyposis type 2 ... [more]
mlh31.004e-1329.63mutL homolog 3 [Source:NCBI gene;Acc:103038515][more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000008212.14.692e-4941.43pep scaffold:Pmarinus_7.0:GL489991:222:4660:1 gene... [more]
pms11.926e-3727.65PMS1 homolog 1, mismatch repair system component [... [more]
mlh11.237e-2826.32mutL homolog 1, colon cancer, nonpolyposis type 2 ... [more]
mlh32.909e-1422.13mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
mlh34.719e-1422.13mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
PMS12.099e-5132.67ATP-binding protein required for mismatch repair; ... [more]
MLH13.299e-2725.95Protein required for mismatch repair in mitosis an... [more]
MLH22.237e-1323.59Protein involved in mismatch repair and meiotic re... [more]
MLH37.947e-1333.01Protein involved in DNA mismatch repair and meioti... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO340144.895e-7037.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO314193.625e-6937.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490033.731e-3828.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO398273.668e-2122.81Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO468318.566e-1724.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of DNA mismatch repair protein PMS2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
pms23.281e-6334.86PMS1 homolog 2, mismatch repair system component [... [more]
pms11.530e-3227.95PMS1 homolog 1, mismatch repair system component [... [more]
mlh13.644e-2625.41mutL homolog 1 [Source:NCBI gene;Acc:111948792][more]
mlh38.651e-1227.22mutL homolog 3 [Source:NCBI gene;Acc:101166595][more]
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BLAST of DNA mismatch repair protein PMS2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000004803.10.000e+094.47SMESG000004803.1[more]
SMESG000011828.13.877e-2627.96SMESG000011828.1[more]
SMESG000066771.17.100e-2629.31SMESG000066771.1[more]
SMESG000066771.11.292e-2529.31SMESG000066771.1[more]
SMESG000007016.11.777e-726.74SMESG000007016.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014562 ID=SMED30014562|Name=DNA mismatch repair protein PMS2|organism=Schmidtea mediterranea sexual|type=transcript|length=4559bp
AAATTTATTTAAAATATTTTATGTGCTTAATTAATTAATAAATTTAATGA
ATATAAAACGCATAAATACACAAACAAGTCAACGAATCTGTTCGAGCCAG
GCTGTAGTTTCTATGGCTGCAGCAATTAAGGAATTAATTGAAAACAGTCT
TGATGCAGATAGTGGGAAAATCGAAATTCGATTAAAAAACTTCGGTGCTG
ATATTATTGAAGTTCTTGATAATGGAACTGGCATTTCACCTCATGAATTC
GATAAATTTACTTCTAGAAATACTACATCAAAATTAGAGAATTTTGATGA
TTTGAACAATTTAGAAACATTTGGATTTAGAGGGGAAGCATTAAATTCCT
TATGTTTTCTAGGGCAGAAAGGAACAACGGTTTCAATACGAAATATATTT
CACACTCTACCCGTTAGGAGAAAACAATTTTTAGGTAATTTGAAAAGGGA
ATTCGATAAAGCTTTGAATTATATTACGAGTTATTGTTTGATATGTGAAG
GTGTTCAAATTTCATGCTGCAAGATTGATAAAAACAAACAAGTTATACTT
TCAACAAGAGGTATTGGTGGAATCTCTGAAAATATTAAATCTGTCTTCGG
TCAAAATCAACTTAATGGAATGATCGAACTTACTACAGAACACAATATCA
ACCAAGATATTTTAGATGAATTTAATATCTCAAAAGTAGCCAATCTTGAA
AAAATTGAATTATCAGGATGGATTTCGCAACCAACTGAAGTTTTTAAGTC
AAGCAATTCTAGTAAACAATTTCTATATGTAAATAGAAGACCCTGTGAAC
TGCCAAAAGTTAAAAGACTTATAGCTGAATGTTACAGAGTCATGAATAAA
ACCCACAACCCAACTTTTGTAATATCAATTTCATTGCCAAAAGAAACCGT
TGATGTAAATATTGAGCCAGATAAACGCATTTTGCTTTTGGATAATCAAT
CTGAAGTTTTTGCTGTAATAAAAGCCTCGATTTTATCTTGCTTTTTAAAA
TCGGGATATTCACAAGAGTACCGGAGTATCAATCAGACACTTTCGGAATC
AGTCAATTCAAAATTTAATAACAATTACACTTTGAATCTATCAGTCAATG
TTGACAATTCTTTACGAAGTCCACATGTGAGAAAGCATAATTTAAGAAGT
CCTGATAAAATTCAAACCAAATTTCCAAAGTTGCAGTTATCTGATCCAAA
TCAAATTAATAGTTGCAGGAAAATGAAATTACCGCTGGTTGTCAGTCAAA
ATATTTCTGCTAATTTTTCCATGAAATACATTAGCCTATTAGATACAAAT
GCTGAAAATGATATTACTAATGCATTTAACGGAAAATACAAATCAGAAAT
ATCGTCTAATAATAATCGAACTGCAGAAGAAGAGTTGAAACGAATATTCC
GAAAGCAATATTTTAATGATCTGGAGGTGATTGGTCAGTTCAACAAAGGA
TTTATAATTGCTCGATTAAATCAGGATCTCTTTATTATTGATCAACATGC
AAGTGATGAGAAAAAACAATTTGAAAAATTTTTAAATCAATGTGAAATGA
GTTCACAACCACTAGCATGTCCAAAACGGCTCCAAATTTCATCGGGGGAC
GAAGAAATTATATCTGAAAATATTGATTTGTTTAATAAATTGGGATTTAG
ATTTCAGTTTAAAGAAGCAGAACTTAATTTTCGAATTTTTATGACTGCTG
TTCCACGTCGCAATAATCTTGTTCTTGGAACCGAAGATTTACATGAGATG
CTTCAAATAATAAAAGACTATGGGTCAACGTGCATAGTAATGCCAATTCG
CGTACGTAGCGCCATTGCATCTAATGCTTGCAGGAGTGCCATCATGATTG
GTACAAGTCTCTCATATGTTCAGATGGATAAAATATTGAAACAAATGAGT
TCTCTAAAAGACCCTTGGACTTGTGCCCATGGACGACCGACGATACGTCA
TCTACATTGCCTTGCTTAATGAACTTGGTCGTCGAATTTTATTATCTGAT
TGTAAAAATAAAAATGCATTACATTATAGTTTCTTAGAAAAAAGAATTAT
GTCCTTGTAAATTTAATTAATTGATTATTCAACTAATCTAGAGTTTATTT
TGCAAATAAATATTTTTTCACATCAAAAATTTTAAAGATTATAAAATTCT
CTCTTTATCGAGTTCAATTTCTTATACTATAAACTATGAGTTCTTGCAAA
TTCTATTGTCTGGACACACGATTTAGCCAGGTCTAAATTTTAATGGGTTT
CTTTAAAATTGGAAAAATTATATCGATCTACAAAACCATCAAATTAAACG
ATTTTTCCGAAATTGAGTGTCTTATAATTTAAAAATGATAAACTTAAGAT
GTTAATGTGAATAGGATATCCGATAATGATTTTACAGTTAAGAAAAACTC
CTGAAAAATATCATGTGCTTTGATAACAATAATATTGATGATCAGTTTAA
ATTTTCATAAAATAAATTATTTTTCTAGTGTTATTAATTGAGGTTTTCAA
TACAAATGCTACTGTAACTAATACGTTGTGTTATGGAATGATTTGTAATT
ATTTTTAGTTAGAGTTATTCTAGAAGTTTGTTGAGCCCAGCTGAGTCTCC
AGTAAAATGGTGTCGGGACGGTCTTGGAAGAATGTTGTGTTTCGTAAATT
TATGTAATTAAATACACAATATCGGAATAAAAAAATATTACCTAACAAAA
CTTAATAATTACAGCATTTTATTAAAGAACAGTTGTTAAAAAAATAATAA
ATAGTAATCTAGATTGTTATGATATATCTGTTGATTGAGGAATTGAAATC
GTCTTGCAAGTCAGCAAAATTAGAAGAATAATATCTATCGGTAGGAATCA
AGCTTTGGGATACCTGTTTAAAATTTTCTTTGATTCGGCAGTAAATTGAT
TTTGACTACAAAATTAGTAGCGGATTTTTATTCTTTAGCTTATCTAATAA
ATTCATTTAATAATTTCGGTTAATCGATTTCTTTTTGCTATTTTCCCTTC
TCTATAGTAATTTTTTTATATAACTATAGGGGTATTGATTGATGGTTTAA
ATTATCAAATTTAATAATTTGATAATTTGAAAAAAAATAAATAGAACACA
AGGAGTTTTACATTAAAGGGGTAAGTGGAGTTGGGAAATAAATAAAAAAA
CAAGATGTACTATTCCACGTTGCAAAAAATGAAACAAAATTCATTAGAAC
TATATATTTAACAAAATTTGTTTAAAATCATAGTACTAAGAAAGATTAAG
AAAGACAGAGACAAAAGATTTGAATTTATTGTGGCTTATTCAAGTGAAAA
AATATTTTATACAGTTTGCAGTTGGATGTCGATATGTCGCAGTAGCCATT
TAAAAACGAAGGAAACTTGACAAACTTTGCCATAAGTGGTAAAAAATAGA
TTCATAAAAGATGATTTACCGAGAACTTCGAGTGATTTTAATCAATGCTT
CCAATCAAATTTACGAGTGTCTATAATGAAATAAATTTCGTGATGACGCT
TGTTACTATCCATAAAAGCAAACTATAATTGTTATTTGAGGTGAACAAAT
AATTTTTAATTTTTTTTGTTAAATTGAAAAAGTGAATTTGAATTGTGTAA
ATCTATTTTGTTAAAAATTACACCTAATTGTATCAGATCTTGTTTCTTTG
AATCAAGACGTGAAGTTAGATTGTGATCAAATCCGTGTTGAAATTGTTAC
AAACCTAAAGTTTAATAAAACTTAAAAGGTTCAAGAGATATCAGTTTGGG
CTGAAAGAGTTCGGAAATTGCTATGCTAAACGTTGTATTATTTGAAGGGA
TGAAACTTTTAATAATTTATTATTTTTTCGTTTTTGTTATGAATTCCAAT
AAAATTAATTTTATTCACTTCAATAAATATCTAATTTGTAATTCATACGC
AATGGTGAGTAATTTGATATCAGCTACACATGATTTTTTGTTTCAGAATT
GTTTTATGATTTATTTTAATTTTGTCTCTTCACTATTTTGGGATTCTATG
ATTGATGCAAATTGTCCGGGAACGATAACCATAACCCGCCTTAACATCAT
TGGGATAGGTTAACCATCTTTCGAGAATTGGTTTGAACTAGTCATGGATT
GATTGTGTAATAATGTATACTTCACTAGTAAAATATATTTTACTAATGAC
TACAATTATCTCACAACTTTTCCAAAATCATGGCTATCGAGATTCAACAT
GATTTTACAAAACTATTTTGTGAAATTGTTATGACTTTGGCGGTGCAATC
GTGACAAAAACCTGCAACATCATACTTGATGTGTAAATACATTTGCTTTA
TTGATTGCTATGATTATAATCATTAAAATAATAGTGATTTATTCTGTTTT
AAATTTTAACCAAAAAAATGAAATATATATTTTTATATGCGGCCCGCAGG
ATTATAAAGGCACACAAGATCATTTGGTTACCAGGGCTGGCAAAGACACT
AATTTTTAATCAATGGCAATGATAGAAGCAGAAATATTGACTAACCATTT
GGCTGCTAAAATGTTTAGCGTTACATAATACAATGTAAGACAATGGCAAC
AACAAAAAA
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protein sequence of SMED30014562-orf-1

>SMED30014562-orf-1 ID=SMED30014562-orf-1|Name=SMED30014562-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=641bp
MNIKRINTQTSQRICSSQAVVSMAAAIKELIENSLDADSGKIEIRLKNFG
ADIIEVLDNGTGISPHEFDKFTSRNTTSKLENFDDLNNLETFGFRGEALN
SLCFLGQKGTTVSIRNIFHTLPVRRKQFLGNLKREFDKALNYITSYCLIC
EGVQISCCKIDKNKQVILSTRGIGGISENIKSVFGQNQLNGMIELTTEHN
INQDILDEFNISKVANLEKIELSGWISQPTEVFKSSNSSKQFLYVNRRPC
ELPKVKRLIAECYRVMNKTHNPTFVISISLPKETVDVNIEPDKRILLLDN
QSEVFAVIKASILSCFLKSGYSQEYRSINQTLSESVNSKFNNNYTLNLSV
NVDNSLRSPHVRKHNLRSPDKIQTKFPKLQLSDPNQINSCRKMKLPLVVS
QNISANFSMKYISLLDTNAENDITNAFNGKYKSEISSNNNRTAEEELKRI
FRKQYFNDLEVIGQFNKGFIIARLNQDLFIIDQHASDEKKQFEKFLNQCE
MSSQPLACPKRLQISSGDEEIISENIDLFNKLGFRFQFKEAELNFRIFMT
AVPRRNNLVLGTEDLHEMLQIIKDYGSTCIVMPIRVRSAIASNACRSAIM
IGTSLSYVQMDKILKQMSSLKDPWTCAHGRPTIRHLHCLA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016887ATPase activity
GO:0005524ATP binding
GO:0030983mismatched DNA binding
GO:0004519endonuclease activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000140anterior region of the whole animal
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR036890HATPase_C_sf
IPR042120MutL_C_dimsub
IPR042121MutL_C_regsub
IPR038973MutL/Mlh/Pms
IPR037198MutL_C_sf
IPR014790MutL_C
IPR013507DNA_mismatch_S5_2-like
IPR003594HATPase_C
IPR014721Ribosomal_S5_D2-typ_fold_subgr
IPR014762DNA_mismatch_repair_CS
IPR020568Ribosomal_S5_D2-typ_fold
Vocabulary: biological process
TermDefinition
GO:0006298mismatch repair
GO:0090305nucleic acid phosphodiester bond hydrolysis
Vocabulary: cellular component
TermDefinition
GO:0032300mismatch repair complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014790MutL, C-terminal, dimerisationSMARTSM00853MutL_C_2coord: 461..605
e-value: 9.3E-28
score: 108.2
IPR014790MutL, C-terminal, dimerisationPFAMPF08676MutL_Ccoord: 460..605
e-value: 3.8E-25
score: 88.4
IPR013507DNA mismatch repair protein, S5 domain 2-likeSMARTSM01340DNA_mis_repair_2coord: 180..317
e-value: 1.5E-25
score: 100.9
IPR013507DNA mismatch repair protein, S5 domain 2-likePFAMPF01119DNA_mis_repaircoord: 183..313
e-value: 9.9E-23
score: 80.1
NoneNo IPR availablePFAMPF13589HATPase_c_3coord: 22..80
e-value: 1.5E-9
score: 37.8
NoneNo IPR availablePANTHERPTHR10073:SF52MISMATCH REPAIR ENDONUCLEASE PMS2-RELATEDcoord: 3..637
NoneNo IPR availableCDDcd16926HATPase_MutL-MLH-PMS-likecoord: 10..162
e-value: 1.41997E-50
score: 171.465
IPR036890Histidine kinase/HSP90-like ATPase superfamilyGENE3DG3DSA:3.30.565.10coord: 1..105
e-value: 1.7E-37
score: 131.0
coord: 106..184
e-value: 8.5E-15
score: 56.8
IPR036890Histidine kinase/HSP90-like ATPase superfamilySUPERFAMILYSSF55874ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinasecoord: 19..166
IPR014721Ribosomal protein S5 domain 2-type fold, subgroupGENE3DG3DSA:3.30.230.10coord: 185..316
e-value: 3.7E-34
score: 119.2
IPR042120MutL, C-terminal domain, dimerisation subdomainGENE3DG3DSA:2.30.42.20coord: 462..636
e-value: 1.8E-36
score: 127.6
IPR042121MutL, C-terminal domain, regulatory subdomainGENE3DG3DSA:3.30.1370.100coord: 500..602
e-value: 1.8E-36
score: 127.6
IPR038973DNA mismatch repair protein MutL/Mlh/PmsPANTHERPTHR10073DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTLcoord: 3..637
IPR014762DNA mismatch repair, conserved sitePROSITEPS00058DNA_MISMATCH_REPAIR_1coord: 93..99
IPR037198MutL, C-terminal domain superfamilySUPERFAMILYSSF118116DNA mismatch repair protein MutLcoord: 457..636
IPR020568Ribosomal protein S5 domain 2-type foldSUPERFAMILYSSF54211Ribosomal protein S5 domain 2-likecoord: 162..316