Transmembrane protein 70-like

Overview
NameTransmembrane protein 70-like
Smed IDSMED30014531
Length (bp)659
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transmembrane protein 70-like (SMED30014531) t-SNE clustered cells

Violin plots show distribution of expression levels for Transmembrane protein 70-like (SMED30014531) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Transmembrane protein 70-like (SMED30014531) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Transmembrane protein 70-like (SMED30014531) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014531

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30014531SMESG000026851.1 dd_Smed_v4_8324_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30014531SMESG000026851.1 dd_Smed_v4_8324_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Transmembrane protein 70-like vs. Ensembl Human
Match: TMEM70 (transmembrane protein 70 [Source:HGNC Symbol;Acc:HGNC:26050])

HSP 1 Score: 50.447 bits (119), Expect = 6.187e-7
Identity = 46/160 (28.75%), Postives = 69/160 (43.12%), Query Frame = 3 
Query:  147 TCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFEN---------LDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDK 599
            T ++ S+ G+LIY       V  VK FS  TS IGL+   ++F           L  +++ Y + G FT +   TP+LLH +TK YV   Y+    D + A+     L +   VF   D ++      F+    K   L      F + +    L G DK
Sbjct:   84 TPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVI---TPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDK 240
[Close]
BLAST of Transmembrane protein 70-like vs. Ensembl Fly
Match: CG7506 (gene:FBgn0035805 transcript:FBtr0076822)

HSP 1 Score: 57.3806 bits (137), Expect = 9.142e-10
Identity = 53/166 (31.93%), Postives = 79/166 (47.59%), Query Frame = 3 
Query:  123 RNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENL----DNELLKYILTGG--FTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKP 602
            R +S+K     ++  L ++ Y        + VK FSL TS  GL+ Q  + E         +  ++ T G  FTF+   TPLLLH +TK YV E +YN   + +TA    + L+K    F+  D  +  VP  F++  V   PL    + F D +   K+ G DKP
Sbjct:   54 RWLSVKSTKTESDDALQRIYYGTLAPRMKM-VKFFSLSTSLAGLAAQPILLEQGMKIGGTGMAVFLCTVGGFFTFV---TPLLLHFITKKYVTELHYNPLTEEYTATTISLLLQKIKTTFRPNDVVVPEVPGMFTSFLVNKRPLFVDPALFDDPEHYVKIMGYDKP 215
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BLAST of Transmembrane protein 70-like vs. Ensembl Zebrafish
Match: tmem70 (transmembrane protein 70 [Source:ZFIN;Acc:ZDB-GENE-070912-593])

HSP 1 Score: 50.447 bits (119), Expect = 2.966e-7
Identity = 42/153 (27.45%), Postives = 67/153 (43.79%), Query Frame = 3 
Query:  159 NSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFE----NLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPF 605
             S+ G LIY       +  VK FS  +S   L +  F+       +++  L+    G   F    TP LLH +TK YV   Y+N++ D++TA+     L ++  VF  +D  +  V   F++   K   +      F+       L G D+PF
Sbjct:   83 QSEDGDLIYSGNLGKAIRGVKLFSYSSSMFSLCVMPFVLMKTGMGVNSLALQVAFCGVIGFFTFLTPALLHFITKGYVIRLYHNKETDMYTAITYSAVLLEKRTVFHQSDVTIPDVSRMFTSFYAKKRSMLVNPMHFSLPHDYNHLMGYDRPF 235
[Close]
BLAST of Transmembrane protein 70-like vs. Ensembl Xenopus
Match: tmem70 (transmembrane protein 70 [Source:NCBI gene;Acc:100380062])

HSP 1 Score: 52.7582 bits (125), Expect = 7.436e-8
Identity = 44/155 (28.39%), Postives = 69/155 (44.52%), Query Frame = 3 
Query:  153 NNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFE----NLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPF 605
            + N + G+LIY      +VL +K FS  TS   + +  ++      ++D+  LK        F    TP+ LHL+TK YV   Y+N + D +TAV     L ++  VF   D ++  V   F+    +   +      F +      L G DKPF
Sbjct:   69 SGNYEDGRLIYTGNLAKSVLGIKFFSYSTSIFSICLMPYIMLKSGISVDSLALKIAFISVVGFFTFVTPVTLHLITKGYVVRLYHNAETDTYTAVTYNALLSEKRTVFHQKDVEIPGVSKMFTTFYAQKKSMLVNPMLFGNPYDYNHLMGYDKPF 223
[Close]
BLAST of Transmembrane protein 70-like vs. UniProt/SwissProt
Match: sp|Q5ZLJ4|TMM70_CHICK (Transmembrane protein 70, mitochondrial OS=Gallus gallus OX=9031 GN=TMEM70 PE=2 SV=1)

HSP 1 Score: 62.003 bits (149), Expect = 2.395e-10
Identity = 50/176 (28.41%), Postives = 85/176 (48.30%), Query Frame = 3 
Query:  108 KISNIRNISLKGITCNNNSDL---GKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFM-------FENLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPF 605
            ++++ + ++++ ++ +  SD    G+L+Y       VL V+ FS  TS   L M  ++       F++L  +   Y L G FTF+   TP+ LH+LTK YV   YY E+ D +TA+     L ++  VF   D ++  +   F+    K   +    + F D     +L G DK F
Sbjct:   60 EVASFQGVAVRSLSTSAPSDHPEHGRLVYKGNLAKAVLGVRFFSYSTSIFNLFMAPYLMLKTGIGFDSLFLQAAFYGLIGFFTFV---TPVTLHILTKGYVIRLYYKEEMDTYTAITYNAILAEKATVFHQKDVKIPDITKMFTTFYAKTKSMLVNPTLFPDPQDYNRLMGYDKAF 232
[Close]
BLAST of Transmembrane protein 70-like vs. UniProt/SwissProt
Match: sp|Q95SS8|TMM70_DROME (Transmembrane protein 70 homolog, mitochondrial OS=Drosophila melanogaster OX=7227 GN=CG7506 PE=2 SV=1)

HSP 1 Score: 57.3806 bits (137), Expect = 9.164e-9
Identity = 53/166 (31.93%), Postives = 79/166 (47.59%), Query Frame = 3 
Query:  123 RNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENL----DNELLKYILTGG--FTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKP 602
            R +S+K     ++  L ++ Y        + VK FSL TS  GL+ Q  + E         +  ++ T G  FTF+   TPLLLH +TK YV E +YN   + +TA    + L+K    F+  D  +  VP  F++  V   PL    + F D +   K+ G DKP
Sbjct:   54 RWLSVKSTKTESDDALQRIYYGTLAPRMKM-VKFFSLSTSLAGLAAQPILLEQGMKIGGTGMAVFLCTVGGFFTFV---TPLLLHFITKKYVTELHYNPLTEEYTATTISLLLQKIKTTFRPNDVVVPEVPGMFTSFLVNKRPLFVDPALFDDPEHYVKIMGYDKP 215
[Close]
BLAST of Transmembrane protein 70-like vs. UniProt/SwissProt
Match: sp|Q9BUB7|TMM70_HUMAN (Transmembrane protein 70, mitochondrial OS=Homo sapiens OX=9606 GN=TMEM70 PE=1 SV=2)

HSP 1 Score: 50.447 bits (119), Expect = 2.971e-6
Identity = 46/160 (28.75%), Postives = 69/160 (43.12%), Query Frame = 3 
Query:  147 TCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFEN---------LDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDK 599
            T ++ S+ G+LIY       V  VK FS  TS IGL+   ++F           L  +++ Y + G FT +   TP+LLH +TK YV   Y+    D + A+     L +   VF   D ++      F+    K   L      F + +    L G DK
Sbjct:   84 TPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVI---TPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDK 240
[Close]
BLAST of Transmembrane protein 70-like vs. TrEMBL
Match: R7U9L6 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_174427 PE=4 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.138e-19
Identity = 58/151 (38.41%), Postives = 83/151 (54.97%), Query Frame = 3 
Query:  156 NNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDN--ELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKP 602
             + D G L+Y       V   K FSL +S + L +Q F+   LD+   +L++ ++GG +F I+ TP+LLH LTK YV   Y+N  E+ FTA    + LR++L  F   D ++ S PM  + + VK  PL F  S F D DA  KL   D+P
Sbjct:   55 RHPDRGTLVYAGTLSRMVKAAKIFSLGSSMVALGLQPFIVAQLDSLPRVLQFAVSGGVSFFILVTPVLLHFLTKRYVTSIYFNRDEEEFTAATYTVVLREKLHKFSVKDIEVPSSPMLLTTVTVKGTPLFFDPSYFIDQDAYNKLMKYDEP 205
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BLAST of Transmembrane protein 70-like vs. TrEMBL
Match: A0A4S2LAU2 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008664 PE=4 SV=1)

HSP 1 Score: 87.4261 bits (215), Expect = 9.919e-18
Identity = 57/154 (37.01%), Postives = 88/154 (57.14%), Query Frame = 3 
Query:  156 NNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNE--LLKYILTG-GFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ 608
            +++  G L+Y +  +N VL  K FSLF+S   L  Q F+   L N   LL  +L+  GF    + TPLLLH++T+S+V E Y+++  +VFTA  RGI L ++ + F + +       +  +NI V+ +PL   E++F D    KKL G DKP +
Sbjct:   34 HHTTTGDLVYKSPNRNVVLYAKSFSLFSSSCVLLFQPFVVMKLSNPGLLLVAVLSSVGFA---VTTPLLLHIITRSHVSELYFDKNTEVFTAFTRGILLNRKRIEFTAEEVTCTEGSVSMANINVRGVPLFVSETEFEDRTLYKKLMGFDKPLK 184
[Close]
BLAST of Transmembrane protein 70-like vs. TrEMBL
Match: H2KP18 (Transmembrane protein 70 homolog mitochondrial OS=Clonorchis sinensis OX=79923 GN=CLF_101201 PE=4 SV=1)

HSP 1 Score: 88.1965 bits (217), Expect = 1.657e-17
Identity = 56/158 (35.44%), Postives = 85/158 (53.80%), Query Frame = 3 
Query:  135 LKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ 608
            ++G    ++   G L+Y +  +N VL  K FSLF+S   L  Q F+   L N  L  +         + TPLLLH++T+S+V E Y+++  +VFTA  RGI L K+ + F + +       +  +NI V+ +PL   E+DF D    KKL G DKP +
Sbjct:   89 VRGWRRGHHVTTGDLVYKSPNRNVVLYAKSFSLFSSSCVLLFQPFIVMKLSNPGLLLVAVLSSLSFAVTTPLLLHIITRSHVSELYFDKNTEVFTAFTRGILLNKKRIEFTAEEVTCTEGSVSMANINVRGVPLFVSETDFEDQTLYKKLMGFDKPLK 246
[Close]
BLAST of Transmembrane protein 70-like vs. TrEMBL
Match: A0A2H1C2Q2 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_11368 PE=4 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 2.038e-17
Identity = 55/147 (37.41%), Postives = 81/147 (55.10%), Query Frame = 3 
Query:  171 GKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILTG-GFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ 608
            G L+Y +  +N V   K FSLF+S + LS Q F+   + +     +    G +F ++ TPLLLHL+T+S+V+E YYN     FTA  RG+FL ++ + F  TD          +N+ V+  PL   E+DF+D    K L G DKP +
Sbjct:   56 GTLVYRSSNRNIVFYAKAFSLFSSSVILSFQPFVVMKISSSGATLVAVACGLSFSVL-TPLLLHLITRSHVHEMYYNNVTKKFTAYTRGLFLTQKQLSFAVTDVSCCEPGFSMANLAVRGTPLFISETDFSDLVLYKYLMGFDKPMK 201
[Close]
BLAST of Transmembrane protein 70-like vs. TrEMBL
Match: A0A3S0Z2Q1 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_022765 PE=4 SV=1)

HSP 1 Score: 85.8853 bits (211), Expect = 1.718e-16
Identity = 62/168 (36.90%), Postives = 87/168 (51.79%), Query Frame = 3 
Query:  105 FKISNIRNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILT--GGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKP 602
            F IS  RN S +  + N++   G L+Y  +  +    +K FSL TS +GLS+Q ++F    +  L   +         +   PLL+H + K YV E Y+NE+  VFTAV    F RK   VF + D  +  VP  FS + +K  PL   ESDFTD +  K + G DKP
Sbjct:   91 FSIS--RNFSTQ--SQNDDPGKGSLVYVGRIGSMFKTLKLFSLTTSIVGLSLQPYLFFTYQDAPLVTAVPFFAALNMFVFVNPLLIHHIGKKYVMEVYFNERTKVFTAVLMSFFARKYNFVFTADDVNVPDVPGMFSILTIKGRPLFVLESDFTDMEIYKHMMGFDKP 254
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BLAST of Transmembrane protein 70-like vs. Ensembl Cavefish
Match: tmem70 (transmembrane protein 70 [Source:NCBI gene;Acc:103030425])

HSP 1 Score: 51.6026 bits (122), Expect = 1.236e-7
Identity = 43/149 (28.86%), Postives = 66/149 (44.30%), Query Frame = 3 
Query:  171 GKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFE----NLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPF 605
            G LIY       VL VK FS  TS   + +  ++       +D+  +K    G   F    TP+LLH++TK YV   Y+N+  D++TAV   +FL ++   F  ++  +  V   F+N       +      F        L G D+PF
Sbjct:   91 GALIYTGSLGKAVLGVKFFSYSTSMFSMCVMPYLMMKTGIGVDSLAMKVAFCGIIGFFTFMTPVLLHMITKGYVVRLYHNKDTDMYTAVTYSVFLVEKKSRFHQSEVTVPDVSKMFTNFYANKCAMLVNPELFEIPQDYNHLMGYDRPF 239
[Close]
BLAST of Transmembrane protein 70-like vs. Planmine SMEST
Match: SMESG000026851.1 (SMESG000026851.1)

HSP 1 Score: 349.362 bits (895), Expect = 3.542e-124
Identity = 180/181 (99.45%), Postives = 180/181 (99.45%), Query Frame = 3 
Query:   66 MFTRFFLGKSLGIFKISNIRNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILTGGFTFLIIGTPXXXXXXTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ 608
            MFTRFFLGKSLGIF ISNIRNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILTGGFTFLIIGTPLLLHLLTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ
Sbjct:    1 MFTRFFLGKSLGIFTISNIRNISLKGITCNNNSDLGKLIYDAQKKNTVLRVKGFSLFTSGIGLSMQKFMFENLDNELLKYILTGGFTFLIIGTPLLLHLLTKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNICVKDIPLNFFESDFTDCDAMKKLYGIDKPFQ 181
The following BLAST results are available for this feature:
BLAST of Transmembrane protein 70-like vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
TMEM706.187e-728.75transmembrane protein 70 [Source:HGNC Symbol;Acc:H... [more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG75069.142e-1031.93gene:FBgn0035805 transcript:FBtr0076822[more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tmem702.966e-727.45transmembrane protein 70 [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tmem707.436e-828.39transmembrane protein 70 [Source:NCBI gene;Acc:100... [more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q5ZLJ4|TMM70_CHICK2.395e-1028.41Transmembrane protein 70, mitochondrial OS=Gallus ... [more]
sp|Q95SS8|TMM70_DROME9.164e-931.93Transmembrane protein 70 homolog, mitochondrial OS... [more]
sp|Q9BUB7|TMM70_HUMAN2.971e-628.75Transmembrane protein 70, mitochondrial OS=Homo sa... [more]
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BLAST of Transmembrane protein 70-like vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7U9L61.138e-1938.41Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A4S2LAU29.919e-1837.01Uncharacterized protein OS=Opisthorchis felineus O... [more]
H2KP181.657e-1735.44Transmembrane protein 70 homolog mitochondrial OS=... [more]
A0A2H1C2Q22.038e-1737.41Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
A0A3S0Z2Q11.718e-1636.90Uncharacterized protein OS=Elysia chlorotica OX=18... [more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tmem701.236e-728.86transmembrane protein 70 [Source:NCBI gene;Acc:103... [more]
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BLAST of Transmembrane protein 70-like vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transmembrane protein 70-like vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000026851.13.542e-12499.45SMESG000026851.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014531 ID=SMED30014531|Name=Transmembrane protein 70-like|organism=Schmidtea mediterranea sexual|type=transcript|length=659bp
GTGCGTATTTTCAAAGTTATGAATTAATATAATTTAAATTTTTAAATTGA
TTGTAAAAATATATAATGTTTACACGATTTTTCTTAGGGAAATCTTTAGG
AATTTTTAAAATTTCCAATATTAGAAATATTAGCTTGAAAGGTATTACTT
GTAATAATAACTCGGATTTAGGTAAATTAATTTATGATGCTCAGAAGAAA
AATACTGTATTAAGAGTTAAGGGATTTTCATTATTCACAAGTGGAATAGG
ATTATCAATGCAGAAGTTTATGTTTGAAAATCTTGATAATGAATTATTGA
AGTATATTTTAACTGGTGGTTTTACTTTTTTAATAATAGGAACCCCATTA
TTATTGCATTTATTGACAAAAAGTTATGTATATGAATGCTATTATAATGA
GAAAGAAGATGTTTTTACTGCCGTAAAAAGAGGAATATTTCTCCGTAAGG
AATTGGTCGTTTTTAAATCAACCGATTGCCAATTGAAATCAGTTCCGATG
CCATTTTCTAACATTTGTGTCAAAGATATTCCTTTAAATTTCTTTGAAAG
TGATTTTACAGATTGTGATGCCATGAAAAAGTTATATGGAATCGATAAAC
CTTTTCAAATAAAAAACTAATAAAACTTGTTAATAAAATTAAAAATTGTT
TTTGTTACA
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protein sequence of SMED30014531-orf-1

>SMED30014531-orf-1 ID=SMED30014531-orf-1|Name=SMED30014531-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=185bp
MFTRFFLGKSLGIFKISNIRNISLKGITCNNNSDLGKLIYDAQKKNTVLR
VKGFSLFTSGIGLSMQKFMFENLDNELLKYILTGGFTFLIIGTPLLLHLL
TKSYVYECYYNEKEDVFTAVKRGIFLRKELVVFKSTDCQLKSVPMPFSNI
CVKDIPLNFFESDFTDCDAMKKLYGIDKPFQIKN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR009724TMEM70
Vocabulary: biological process
TermDefinition
GO:0008203cholesterol metabolic process
GO:0016042lipid catabolic process
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0016298lipase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009724TMEM70 familyPFAMPF06979TMEM70coord: 51..178
e-value: 6.7E-27
score: 94.5
IPR009724TMEM70 familyPANTHERPTHR13281UNCHARACTERIZEDcoord: 33..178
NoneNo IPR availableTMHMMTMhelixcoord: 78..100