Trafficking protein particle complex subunit 6b

Overview
NameTrafficking protein particle complex subunit 6b
Smed IDSMED30014486
Length (bp)1006
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Trafficking protein particle complex subunit 6b (SMED30014486) t-SNE clustered cells

Violin plots show distribution of expression levels for Trafficking protein particle complex subunit 6b (SMED30014486) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014486

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30014486 dd_Smed_v4_5931_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30014486 dd_Smed_v4_5931_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Human
Match: TRAPPC6B (trafficking protein particle complex 6B [Source:HGNC Symbol;Acc:HGNC:23066])

HSP 1 Score: 50.447 bits (119), Expect = 3.184e-7
Identity = 33/99 (33.33%), Postives = 48/99 (48.48%), Query Frame = 2 
Query:  578 ESVEFNSGSGL-RRYSLSVLAYIGSLSIWFCSFDCEIVYVPKYA------QLNHD*L*SIGL*FQFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            E++ F  G GL  R++     +   L I    F C+  +   +       + NH          Q+L   CG+I+G L+NLGI S VTAEV ++P CKF
Sbjct:   37 ENMGFRVGQGLIERFTKDTARFKDELDI--MKFICKDFWTTVFKKQIDNLRTNH----------QYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKF 123
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Human
Match: TRAPPC6B (trafficking protein particle complex 6B [Source:HGNC Symbol;Acc:HGNC:23066])

HSP 1 Score: 46.9802 bits (110), Expect = 6.867e-6
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            ++L   CG+I+G L+NLGI S VTAEV ++P CKF
Sbjct:  117 KYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKF 151
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Fly
Match: Trs33 (gene:FBgn0266722 transcript:FBtr0083116)

HSP 1 Score: 51.6026 bits (122), Expect = 8.360e-8
Identity = 22/35 (62.86%), Postives = 29/35 (82.86%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            +F+   CG+++GAL+NLGI S VTAEVQ+IP CKF
Sbjct:  111 KFVAFTCGLVRGALSNLGINSTVTAEVQSIPACKF 145
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Zebrafish
Match: trappc6bl (trafficking protein particle complex 6b-like [Source:ZFIN;Acc:ZDB-GENE-040426-1602])

HSP 1 Score: 46.595 bits (109), Expect = 6.629e-6
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            ++L   CG+I+GAL+NLG+ S VTAEV  +P CKF
Sbjct:  120 KYLAFSCGMIRGALSNLGLESVVTAEVSLMPSCKF 154
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Zebrafish
Match: trappc6bl (trafficking protein particle complex 6b-like [Source:ZFIN;Acc:ZDB-GENE-040426-1602])

HSP 1 Score: 46.595 bits (109), Expect = 6.629e-6
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            ++L   CG+I+GAL+NLG+ S VTAEV  +P CKF
Sbjct:  120 KYLAFSCGMIRGALSNLGLESVVTAEVSLMPSCKF 154
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Mouse
Match: Trappc6b (trafficking protein particle complex 6B [Source:MGI Symbol;Acc:MGI:1925482])

HSP 1 Score: 46.9802 bits (110), Expect = 1.659e-6
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            ++L   CG+I+G L+NLGI S VTAEV ++P CKF
Sbjct:   55 KYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKF 89
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Mouse
Match: Trappc6b (trafficking protein particle complex 6B [Source:MGI Symbol;Acc:MGI:1925482])

HSP 1 Score: 46.9802 bits (110), Expect = 4.670e-6
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKF 853
            ++L   CG+I+G L+NLGI S VTAEV ++P CKF
Sbjct:  117 KYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKF 151
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Match: A0A2B4SIV5 (Uncharacterized protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene6913 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 1.523e-17
Identity = 48/94 (51.06%), Postives = 62/94 (65.96%), Query Frame = -1 
Query:   41 LTKSYHLIKTHKDGPSIKIRPIASNTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFNYTFSLDVVALYTSIDPCEAI 322
            L + YH++KTHK GP I+IRPI SN NGPT   SWLL+ +LKP+L +VP HL+SS  L+  +      T+ +  Y  S DVV+LYT I   EAI
Sbjct:   66 LPRFYHVVKTHKAGPDIEIRPIVSNINGPTQCISWLLANVLKPMLKNVPAHLESSLELIRCIEAGDLTTNKQLPYPCSFDVVSLYTPIPIQEAI 159
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Match: A0A016W2Z7 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0002.g754 PE=4 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 4.442e-11
Identity = 57/184 (30.98%), Postives = 86/184 (46.74%), Query Frame = -1 
Query:   41 NLSKPYVYLPSDKGGQFCVIEK------SRYCEAHSNPYKKISGMSPNTIETKIRKTGKEIAAKMNLKEKLTKS----------YHLIKTHK----------DGPSIKIRPIASNTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFNYTFSLDVVALYTSIDPCEAI 514
            NL K   Y  SDKGG F V+ +      SR   + +  Y++ S    + +   +R T K +  K+   E + +           Y LIKTHK          D   IK+RPI S+  GP+ + SW L K+L PLL+ V  H+ +    ++ LN        +  Y  S D V+LYT+++  EA+
Sbjct:   29 NLRKELRYSVSDKGGDFVVLTQTLDKKISRDNISDTTLYERSSLRDFDKVSNDLRSTIKRVLGKIMNTETVKRFIPTFPTVPTYYALIKTHKIPAGIDSQNMDERGIKVRPIISSCGGPSDRISWFLVKLLSPLLHHVAAHITNVQGFISALNNC--ELPKDVCYA-SFDAVSLYTNVNNDEAV 209
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Match: A0A016VEW2 (Reverse transcriptase domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0011.g1482 PE=4 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 6.836e-10
Identity = 58/184 (31.52%), Postives = 86/184 (46.74%), Query Frame = -1 
Query:   41 NLSKPYVYLPSDKGGQFCVIEK------SRYCEAHSNPYKKISGMSPNTIETKIRKTGKEIAAK-MNLKE---------KLTKSYHLIKTHK----------DGPSIKIRPIASNTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFNYTFSLDVVALYTSIDPCEAI 514
            NL K   Y  SDKGG F V+ +      SR   + +  Y++ S    + +   +R T K +  K MN +           +   Y LIKTHK          D   IK+RPI S+  GP+ + SW L K+L PLL+ V  H+ +    ++ LN        +  Y  S D V+LYT+++  EA+
Sbjct:   88 NLRKELRYSVSDKGGDFVVLTQTLDKKISRDNISDTTLYERSSLRDFDKVSNDLRSTIKRVLGKIMNTRTVKRFIPTFPTVPTYYALIKTHKIPAGIDSQNMDERGIKVRPIISSCGGPSDRISWFLVKLLSPLLHHVAAHITNVQGFISALNNC--ELPKDVCYA-SFDAVSLYTNVNNDEAV 268
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Match: A0A016VF89 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0011.g1482 PE=4 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 8.218e-10
Identity = 58/184 (31.52%), Postives = 86/184 (46.74%), Query Frame = -1 
Query:   41 NLSKPYVYLPSDKGGQFCVIEK------SRYCEAHSNPYKKISGMSPNTIETKIRKTGKEIAAK-MNLKE---------KLTKSYHLIKTHK----------DGPSIKIRPIASNTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFNYTFSLDVVALYTSIDPCEAI 514
            NL K   Y  SDKGG F V+ +      SR   + +  Y++ S    + +   +R T K +  K MN +           +   Y LIKTHK          D   IK+RPI S+  GP+ + SW L K+L PLL+ V  H+ +    ++ LN        +  Y  S D V+LYT+++  EA+
Sbjct:   88 NLRKELRYSVSDKGGDFVVLTQTLDKKISRDNISDTTLYERSSLRDFDKVSNDLRSTIKRVLGKIMNTRTVKRFIPTFPTVPTYYALIKTHKIPAGIDSQNMDERGIKVRPIISSCGGPSDRISWFLVKLLSPLLHHVAAHITNVQGFISALNNC--ELPKDVCYA-SFDAVSLYTNVNNDEAV 268
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Match: A0A016S753 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0283.g1299 PE=4 SV=1)

HSP 1 Score: 70.8626 bits (172), Expect = 1.003e-9
Identity = 55/179 (30.73%), Postives = 86/179 (48.04%), Query Frame = -1 
Query:   35 YLPSDKGGQFCVIEKS------RYCEAHSNPYKKISGMSPNTIETKIRKTGKEIAAK-MNLKE---------KLTKSYHLIKTHK----------DGPSIKIRPIASNTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFNYTFSLDVVALYTSIDPCEAIEC 493
            Y  SDK G F V+ ++      +   + +N Y+K S  + + +   +R T + I  K MN K           +   Y L+KTHK              +K RPI S+  GP+ + SW L+K+L PLL +V  H+ + +  ++ LN      +N +    S D V+LYT+I+  EAIE 
Sbjct:  120 YSVSDKSGDFVVLTQAMDKKLVKQDLSDTNTYEKSSKTAFDKVSNNLRSTARRILGKIMNAKTIKRFIVTFPAVPTYYALVKTHKIPEDVDLQKLTEKEMKTRPIISSCGGPSDRVSWFLTKLLSPLLRNVAAHVINVEEFISALNHCDLPDNNCYA---SFDAVSLYTNINNDEAIEA 295
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BLAST of Trafficking protein particle complex subunit 6b vs. Planmine SMEST
Match: SMESG000065056.1 (SMESG000065056.1)

HSP 1 Score: 88.9669 bits (219), Expect = 3.486e-21
Identity = 41/42 (97.62%), Postives = 42/42 (100.00%), Query Frame = 2 
Query:  749 QFLILPCGIIQGALANLGIISQVTAEVQNIPHCKFTFKLCNP 874
            +FLILPCGIIQGALANLGIISQVTAEVQNIPHCKFTFKLCNP
Sbjct:  121 KFLILPCGIIQGALANLGIISQVTAEVQNIPHCKFTFKLCNP 162
The following BLAST results are available for this feature:
BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
TRAPPC6B3.184e-733.33trafficking protein particle complex 6B [Source:HG... [more]
TRAPPC6B6.867e-657.14trafficking protein particle complex 6B [Source:HG... [more]
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Trs338.360e-862.86gene:FBgn0266722 transcript:FBtr0083116[more]
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
trappc6bl6.629e-657.14trafficking protein particle complex 6b-like [Sour... [more]
trappc6bl6.629e-657.14trafficking protein particle complex 6b-like [Sour... [more]
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Trappc6b1.659e-657.14trafficking protein particle complex 6B [Source:MG... [more]
Trappc6b4.670e-657.14trafficking protein particle complex 6B [Source:MG... [more]
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BLAST of Trafficking protein particle complex subunit 6b vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2B4SIV51.523e-1751.06Uncharacterized protein OS=Stylophora pistillata O... [more]
A0A016W2Z74.442e-1130.98Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
A0A016VEW26.836e-1031.52Reverse transcriptase domain-containing protein OS... [more]
A0A016VF898.218e-1031.52Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
A0A016S7531.003e-930.73Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trafficking protein particle complex subunit 6b vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000065056.13.486e-2197.62SMESG000065056.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014486 ID=SMED30014486|Name=Trafficking protein particle complex subunit 6b|organism=Schmidtea mediterranea sexual|type=transcript|length=1006bp
TTATTAACAAATTGTTTTCCAATCTTCTTCTTAAGCATTCGATAGCTTCA
CATGGGTCGATAGATGTGTATAATGCTACGACATCAAGACTGAAGGTGTA
ATTGAATTCATTATGGGTGGCTTTGCCAGATTTGTTTAATCTTGCCATGA
GGCAGTCGCTACTCTGGAGATGATACGGTACGCTGTTTAGTAATGGTTTT
AGGATTTTTGAAAGGAGCCAACTTGCCTTGGTTGTTGGTCCATTTGTGTT
CGATGCAATTGGCCTGATTTTAATGGAAGGCCCATCTTTGTGAGTTTTTA
TTAAATGGTAGCTTTTTGTTAGTTTTTCTTTGAGATTCATTTTTGCGGCG
ATTTCTTTCCCTGTCTTTCTGATCTTAGTTTCGATAGTGTTTGGTGACAT
GCCACTAATCTTTTTGTATGGGTTACTATGAGCTTCACAGTAACGGCTTT
TCTCAATAACGCAAAATTGACCTCCTTTATCACTTGGTAAGTATACATAT
GGTTTAGACAGATTTGATTTATATGGTTTCCTTTTTTTCTTCTTTCGGCA
ACATTCATAATCTTTTGACAAACCTTTGAAAGTGTTGAATTTAATTCTGG
ATCTGGATTGCGAAGGTATAGTTTGTCAGTGTTGGCATATATTGGGAGTT
TATCGATTTGGTTTTGCTCATTTGATTGCGAGATAGTCTATGTACCAAAA
TATGCACAACTAAATCATGATTAATTATGATCAATTGGTTTATAATTTCA
GTTTCTAATATTGCCTTGTGGCATTATCCAGGGGGCATTGGCAAATTTAG
GTATAATCAGTCAGGTTACTGCAGAGGTGCAGAATATTCCGCATTGTAAA
TTTACATTCAAGCTATGCAATCCGTGAGTTGCTGACCACCGATTGCTTCA
ATGTTGAATGTGAAATATTCTCAATTCAGTTATTCTGTGATCATATTTGT
TGTTAATAAATTACGGATATTTTTTCATTTAATTTTTAAATAAAAATGAA
AATTTG
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protein sequence of SMED30014486-orf-1

>SMED30014486-orf-1 ID=SMED30014486-orf-1|Name=SMED30014486-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=133bp
MSPNTIETKIRKTGKEIAAKMNLKEKLTKSYHLIKTHKDGPSIKIRPIAS
NTNGPTTKASWLLSKILKPLLNSVPYHLQSSDCLMARLNKSGKATHNEFN
YTFSLDVVALYTSIDPCEAIECLRRRLENNLLI
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR007194TRAPP_component
IPR024096NO_sig/Golgi_transp_ligand-bd
Vocabulary: cellular component
TermDefinition
GO:0005783endoplasmic reticulum
GO:0005794Golgi apparatus
GO:0005801cis-Golgi network
GO:0005802trans-Golgi network
GO:0030008TRAPP complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006888ER to Golgi vesicle-mediated transport
GO:0016192vesicle-mediated transport
Vocabulary: molecular function
TermDefinition
GO:0003674molecular_function