plexin A
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014347 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7Note: Hover over icons to view figure legend
Homology
BLAST of plexin A vs. Ensembl Human
Match: PLXNA1 (plexin A1 [Source:HGNC Symbol;Acc:HGNC:9099]) HSP 1 Score: 259.225 bits (661), Expect = 1.257e-68 Identity = 325/1437 (22.62%), Postives = 605/1437 (42.10%), Query Frame = 2
Query: 1541 NMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTA-IGSLS-ASNRLVC-----TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGND-DSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFK---TKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSNITQF------QKCSLLFAME--KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTV-SGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
++V++ N +YA+ + ++ R + +C T+CE CL P CGWC+ + C +D C A P + + C + V P + V +S+ PL + + N + C F E + + + C P + + PI ++ V L LK + YNC+ ++C CVN F C WC + C + ++ C N DCP + S + + VG I L +N + + + CL S A + +L S+ L C +++ V + + ++ V W GN + I+ I+ ++ C L E C C+ ++CG+C + +C +H C D + W++++ +C P I+++ P + + + G NLG DV+ + + + C +E YIS++Q C+I + + + + + L K F F +P Y + P+ GP GGT I + GS LN GS +V + G P C+ I C +P A + +NI+ + +V++ + +P + +I +++GG + +TG NL + +P + + + C V N++ + C +P+ +N + + L F M+ + + + +TS + PVL +S PT LL + + + N + ++ + +G CT ++ + C + L G++ +TV +G +F G + + + S++ + I+ + +L++VI+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ LDCD ++QAK K+ + YK PYS K ++ + +A I L++ T L TL Y + DG ++ + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 489 DLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADE-PQRFAADLLQCVQLTVQPRN-----------VSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESE-------SVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVC-THNVADCAFLEGRVNVSEDCPQILPSTQ-IYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDV---SDLPVNLSVVWN-GNFV---IDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVG----KVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGS--DVAVSVGGRP--CSFSWRNSREIRCLTPP------------GQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGG-IERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVL----EPLS-PTGLLELKPSSPLILKGR-NLLPPAPGNSRLNYTVLIGSTPCT-LTVSETQLLC--------------EAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRP--------KAADMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1790
BLAST of plexin A vs. Ensembl Human
Match: PLXNA2 (plexin A2 [Source:HGNC Symbol;Acc:HGNC:9100]) HSP 1 Score: 199.134 bits (505), Expect = 3.207e-50 Identity = 220/1063 (20.70%), Postives = 429/1063 (40.36%), Query Frame = 2
Query: 413 FADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAY-SIVTNDRKFHSTVLY---HDQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKH-----EPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEI-MELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQN-INDRIETPVAF-----QFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
++++ L+ C ++QG C+++ DL+ S+K + Y S V + ++ D +LF V +Y F T+S P + DY ++F L+ +T+ + F+IY F ++FL QPE + + R+VR+C D + S++ + C Y + + +A D +A + I ++ D +LF F Y + CA+PI I +++ + +++ C G G++ N D +C + NF I G ++ + + + + +Y +++ +G G L K +E + L + +++F++ ++ +Y +++ ++ R + +C T C +CL P CGWC + C +D+C A W P + ++ C + V PS + S S + VS P + + C F + + V+ + + CI P K++P I ++++ L+L++ ++ V + YNC+ + C CVN+ F C WC N C C N DCP L V E + VG I L +N + + + C+ + A+ S+S + + + +++ V W GN + I+ ++ ++ C E C C+ + ++CG+C+ + +C C + S W++ S KC P I EI+ + + + + G NLG +++ + + + C + YI ++Q C++ + + PV + +F TK +++ F +P V S+ P GP GGT++ + G +L GS V T C + I C + S+ + +++D + +++QFE+ +P V++I +++G ITG NL+ + +P + + S+ VN + + C++P+
Sbjct: 121 YSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDY----FPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGF----VYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGC-TRAGVEYRLLQAAYLAKPGDSLAQAFN-------ITSQDD-----VLFAIFS--KGQKQYHHPPDDSALCAFPIRAINLQIKERLQS-CYQGEGNLELN--WLLGKDVQCTKAPVPID-------DNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSI----DQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQA-WEPNRFAASISQCVSLAVHPSS--ISVSEHSRLLSLVVSDAP-----DLSAGIACAFGN-----LTEVEGQ--VSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TCSFQEGRINISEDCPQL-VPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWN-GNFI---IDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG----VPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSH----QQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT----CEFYGRSMSEIVC-----------VSPPSSNGLGPVPVSVSVDRAHVD-SNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPS 1101 HSP 2 Score: 110.923 bits (276), Expect = 2.049e-23 Identity = 131/512 (25.59%), Postives = 231/512 (45.12%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENTVEYSRKLSKLFE----DELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMF--RQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
HP++ ++++V N ++ K KLF +++F+L F LE + + + ++ S + L L T +LK L+ + DK N+ + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS L + Q + I K E L TL Y + D + + K S +PAS + S + + +S + T ++ PM + PD+ + + L + H++ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD+ W+ + ++D+ KL
Sbjct: 1332 HPVL--RELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDL-EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HDHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKL 1821
BLAST of plexin A vs. Ensembl Human
Match: PLXNB2 (plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104]) HSP 1 Score: 163.31 bits (412), Expect = 2.320e-39 Identity = 178/897 (19.84%), Postives = 351/897 (39.13%), Query Frame = 2
Query: 800 YIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNC-DIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVT-CAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFED---TNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTA----MWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRT------CAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIET--------------ETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSK---EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNK 3391
Y+FF+ NQ ++KH +N + L R+C D +Y S++++ + C D D + + + A+V+ + ++L+ F + + R + C +P+ ++ + RN C G+ + Y D +C S+ CG ++ + +G G + G V+ R G+ + + + T+A +G +DG + K L D + Y + + ++V++ + +YA+ K+ R ++ C + C C P+CGWC+ G+C K +C A WL + R+ K+C + ++ + Q++ +PL LSE D+ L C F + A V+ I C P + P ++ V ++L + + L Y Y+C + + C CV+N++ C W + + C +S + + + CP F P+ I + + N+ D V +S +GS ++K ++ +++ S ++ L + ET ++ + +++C C C Y+C +C + +CV + +C +CP P I I P L I + G NLG D++ N C + + Y S + C I+ ETP + K S +F F P+ S+EP GP GGT + ++G+ L+ GS+ +V+ N + C++ F + + + +++ + L+++ + + + F + NP ++ + ++GG+ +TG + + +
Sbjct: 227 YVFFVFNQ-QDKHPARN---RTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAF--GTCLAASVAAPGSG--------------------RVLYAVF-----SRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHL-PYPLGSRDG---LRGTAVLQRGGLN-LTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWL-WSRS---KSCVAVTSAQPQNMSRRAQGE----VQLTVSPLPALSEEDELL-CLF-GESPPHPARVEGEAVI------CNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNP-EDGIVRAHMEDSCP---------QFLGPSPLVIPMNHETDVNFQGKNLDTV----KGSSLHVGS-----------DLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTS---------ECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRN-----CSFQPERYSVSTRIVCVIEA----AETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTL--------------NGVPCKVTKFGAQLQCVTGPQATR-GQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQR 1013 HSP 2 Score: 112.464 bits (280), Expect = 8.158e-24 Identity = 132/538 (24.54%), Postives = 248/538 (46.10%), Query Frame = 2
Query: 4337 KLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIAL---KEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT--SFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIK---GTGSFNYNEYYGS---SRIDGINISLAIVILYQNYINSVHKELVEVIQ 5860
+ S L + F++ F LE+ +E ++ K S L++ L L YT I+ L ++ + + + M R+S+ ++ ++LSNW I +Y +L++ +AG L L+ I + + GPV+ K++Y LN+ LL +E+ L + V + D+ + V+VL+CD ISQ K KI +++Y+ P S W +S L + + ++L+ + L +E + TL Y+++DG + ++ VS +S +D+P + L + ++ + R +D + E S++ +K K + A + IY L S ++G ++ D+ F +VP V F + +D+ + K+NSL LRFW+ ++ N F+FDV + H V L +++ MD C+ ++K L++ L++ I Y V +YY+GI+ + N + + D +N +A+ LYQ Y + E++ ++
Sbjct: 1318 QFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKD-SAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVL----EWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILS----------KVGVSQQPEDS-----------QQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVK--EKERTKAITE---------IYLTRLLS-VKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHV--HEVVDASLSVIAQTFMDACTRTEHK---LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQ-YTQKYYDEIINALE 1810
BLAST of plexin A vs. Ensembl Human
Match: PLXNB2 (plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104]) HSP 1 Score: 163.31 bits (412), Expect = 2.320e-39 Identity = 178/897 (19.84%), Postives = 351/897 (39.13%), Query Frame = 2
Query: 800 YIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNC-DIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVT-CAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFED---TNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTA----MWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRT------CAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIET--------------ETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSK---EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNK 3391
Y+FF+ NQ ++KH +N + L R+C D +Y S++++ + C D D + + + A+V+ + ++L+ F + + R + C +P+ ++ + RN C G+ + Y D +C S+ CG ++ + +G G + G V+ R G+ + + + T+A +G +DG + K L D + Y + + ++V++ + +YA+ K+ R ++ C + C C P+CGWC+ G+C K +C A WL + R+ K+C + ++ + Q++ +PL LSE D+ L C F + A V+ I C P + P ++ V ++L + + L Y Y+C + + C CV+N++ C W + + C +S + + + CP F P+ I + + N+ D V +S +GS ++K ++ +++ S ++ L + ET ++ + +++C C C Y+C +C + +CV + +C +CP P I I P L I + G NLG D++ N C + + Y S + C I+ ETP + K S +F F P+ S+EP GP GGT + ++G+ L+ GS+ +V+ N + C++ F + + + +++ + L+++ + + + F + NP ++ + ++GG+ +TG + + +
Sbjct: 227 YVFFVFNQ-QDKHPARN---RTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAF--GTCLAASVAAPGSG--------------------RVLYAVF-----SRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHL-PYPLGSRDG---LRGTAVLQRGGLN-LTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWL-WSRS---KSCVAVTSAQPQNMSRRAQGE----VQLTVSPLPALSEEDELL-CLF-GESPPHPARVEGEAVI------CNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNP-EDGIVRAHMEDSCP---------QFLGPSPLVIPMNHETDVNFQGKNLDTV----KGSSLHVGS-----------DLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTS---------ECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRN-----CSFQPERYSVSTRIVCVIEA----AETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTL--------------NGVPCKVTKFGAQLQCVTGPQATR-GQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQR 1013 HSP 2 Score: 112.464 bits (280), Expect = 8.158e-24 Identity = 132/538 (24.54%), Postives = 248/538 (46.10%), Query Frame = 2
Query: 4337 KLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIAL---KEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT--SFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIK---GTGSFNYNEYYGS---SRIDGINISLAIVILYQNYINSVHKELVEVIQ 5860
+ S L + F++ F LE+ +E ++ K S L++ L L YT I+ L ++ + + + M R+S+ ++ ++LSNW I +Y +L++ +AG L L+ I + + GPV+ K++Y LN+ LL +E+ L + V + D+ + V+VL+CD ISQ K KI +++Y+ P S W +S L + + ++L+ + L +E + TL Y+++DG + ++ VS +S +D+P + L + ++ + R +D + E S++ +K K + A + IY L S ++G ++ D+ F +VP V F + +D+ + K+NSL LRFW+ ++ N F+FDV + H V L +++ MD C+ ++K L++ L++ I Y V +YY+GI+ + N + + D +N +A+ LYQ Y + E++ ++
Sbjct: 1318 QFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKD-SAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDA-IPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVL----EWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILS----------KVGVSQQPEDS-----------QQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVK--EKERTKAITE---------IYLTRLLS-VKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHV--HEVVDASLSVIAQTFMDACTRTEHK---LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQ-YTQKYYDEIINALE 1810
BLAST of plexin A vs. Ensembl Human
Match: PLXNA4 (plexin A4 [Source:HGNC Symbol;Acc:HGNC:9102]) HSP 1 Score: 162.54 bits (410), Expect = 4.810e-39 Identity = 244/1171 (20.84%), Postives = 455/1171 (38.86%), Query Frame = 2
Query: 158 ENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAYSIVTNDRK--FHSTVLYH--DQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRK-------DAFF------KNYIFFLVNQPENKHEP----KNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDN-QWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNL---CLVGSGSVNENPYNFK----STDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENL----FNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPI-AENKN--FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQ----PDCPT-LEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQV--FDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKW--INSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDR-----IETPVAF-QFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFR--CETFLSIYENCFVNNSDIDCISPTTS 3487
E + +++ H I + N I + S ++LK L +TGP + C P QT C + L + + L L + ++ L+ C ++QG C+++ DL+ +K + Y N+ F V Y D +LF A V Y FP ++ K +A+ G Y +F EFV S S D ++ N+++FL QPE P K ++ +LVR+C D + S++++ + C+ ++ Q A +S A R + D D +LF F + + S A I + ++ D ++ C G G+++ K S+ ++D F CG + D + G V + + + S+I + +Y+ +LA +G G L K + E + + +M +++ +Y +++ ++ R + +C +C +CL P CGWC+ + C K++C + P + +K C + V P++ + S + ++ + P E + C F +++ + + + + C P K +P I EN + V L+LK + YNC+ +C CV + + C WC + C K Q + DCP L V + V PI+ L KN + + + C+ S A+ S+S + T + ++ ++ + V W G + P + +V + C + E C C+ + CG+C +C + C +S+W ++ KC P I EIIP + + ++G NLG D+ + + + C + YI ++Q C++ +E VA + +F + L + F + + ++P+ GP GGT + + G+ LN GS V F G P C +YI C D+++ K S +A + D+ F++ +P + +I + +G + G +L+ + P + + + ++I E +N +++ C +P +
Sbjct: 49 EGFNHLVVDERTGH--IYLGAVNRIYKLS-SDLKV-LVTHETGPDEDNPKCYPPRIVQT--CNEPLTTTNNVNKML------LIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEY------------FPTISSRKLTKNSEAD-GMFAY-----VFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQA-----AYLSKAGAVLGRT------LGVHPDDD---LLFTVF-----SKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNF-------CGLDMNAPLGVSDM-----VRGIPVFTEDRDRMTSVIAY-VYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKE-PRRFASEMKQCVRLTVHPNN--ISVSQYNVLLVLETYNVP-----ELSAGVNCTF-----EDLSEMDG--LVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHDP-----KTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPIT--LKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVW------NGHFNIDNPAQNKVHLYKCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVE----CSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQL----YYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMF--GKQP--CLFHRRSPSYIVCNTTS---SDEVLEMKVSVQVDRAKIH----------QDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICE--VLNATEMTCQAPALA 1102 HSP 2 Score: 110.538 bits (275), Expect = 2.918e-23 Identity = 132/524 (25.19%), Postives = 235/524 (44.85%), Query Frame = 2
Query: 4277 HPLIVNKQIQVI-ENTVEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSR------NISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
HP++ + ++ + VE KL ++L +++F+L F LE + + + ++ S + +L L T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L L+ I + GP++ T +++Y+L+E+ L+ ++I++K L L N E+ V++L+CD I+Q K KI + I+K P S+ W +I ++D + E L TL Y + DG VA+ ++ + A N + S + SAS N R ++ PM + PD+ + + L + HE+ QK + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++ KD+ W+ + +SD+ K+
Sbjct: 1332 HPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDITTKIENDWK----------RLNTLAHYQVPDGS--VVALVSKQVTAYNAVNNSTVSRTSASKYENMIRYTGSPDSLRSRTPMIT--PDLESGVKMWHLVKN-HEHGDQKEGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKM 1821
BLAST of plexin A vs. Ensembl Celegans
Match: plx-1 (PLeXin [Source:UniProtKB/TrEMBL;Acc:U4PC90]) HSP 1 Score: 292.738 bits (748), Expect = 1.880e-79 Identity = 413/1791 (23.06%), Postives = 723/1791 (40.37%), Query Frame = 2
Query: 725 ETIFPLEFVGSFHIYDSRKDAFFK------------NYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTS-TGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYL--FSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYN-GTNCEDCLRV-SPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGI--YHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF----------EIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST--AIGSLSASNRLVCTFQMMK-----VLQKASIKCSMKVSWILGNLLTGS------IETETPIEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKC-----KIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIY-ENCFVNNSD-IDCISPTTSNITQ---FQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIK--QKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQV--IENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDS--ELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPA---------------CLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGT 5731
E +FP + G+ D R ++K +Y +F+ Q N + + Q RLVR+C+ D ++ S+ ++ + C T V +V +V A + K+ + D + + + K N+YR E C + + EI + C G+ + +N F S D C FT+ +G GK+ N I GD S + + + I + T+A +G G L+K L E ++TE L +N I +M + +Y + SK+I+ C T C+ CL P+CGWC+SN C ++ C T+ WL FQ ++ CP I + I + V + + P + ++C F + + + + + SL C P +P I N+ + KL V+ + S L + Y+C +C+ C ++F C WC+ N C++ L KC+K I+ CP + +S G +I + +N F DF C T I ++ + + C + + +L S V W G ++ + V+ C L+ +C C+ L Y CG+C++ KC + H C N W+N+ Q CP P I + P ++ + + + G NLG + +DV+ A+ + N C+ +E Y+ S++ C I+ N+R VA + + + S E F + P V S++P GP GGT + + G L+ G+ V+F I C ILE ++ CR+ S + L + D + FEF +P V+ IS NK + +GG + G L +P + F Y C + + + C +PT Q+ +A + +Y + I + +P +S P R ++ + +T+N + ++++A + D + VG C + + C Q + L + V+TV G F G++S D+ + + +++ I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN H ++ N ++ E R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V S ++ V VLDCD I+Q K K + Y+ +++ + +++ K+ ++ S R+ + L TL Y++ + + + K+ SL N + S +AS+ +++S S + P ++D H +SS + + FK H +KP L ++K + I +L + IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I T
Sbjct: 15 EVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIAD--DSSIQSRLVRVCTGDKNFHSYTEVPLEC------TQNGVEFNLVQDVYVTRAGYELAKSLDISVS---DPVLYGVFWEGDK-----NSYRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDD-CR---FTTLPWEGIKCGKDVNSKIGGDTPISTSAT---YVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKI-LIESKRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSK----CPRIRSVKPDQIQINTADYLNVTIENLQAP------KGRRMQCLFQFSTGDAVVSDPMPF---DGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDATFMG--DFKCEFKYGTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNAS-QLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIAN----VPCEVVE--YVPSQKIVCVTGKSPIKGSNER--GVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQ----IGCKILERASGWLRCRMG------------ASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFET----LSEP----RFVRPGEDFLTLN---GNHLNLAA-SERDIDVKVGGEPCPLTALANKVLTC------QPPVKKPRGAGKLNPEIVVTV-GNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNAGK---------------------------NHAVLKNLEVDTHKAEAIEAGLREFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSL--YNLVNFSSTSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIAD--HASSSADTD---------NGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDI--QKPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMT 1667
BLAST of plexin A vs. Ensembl Celegans
Match: plx-1 (PLeXin [Source:UniProtKB/TrEMBL;Acc:U4PC90]) HSP 1 Score: 291.967 bits (746), Expect = 4.347e-79 Identity = 413/1791 (23.06%), Postives = 723/1791 (40.37%), Query Frame = 2
Query: 725 ETIFPLEFVGSFHIYDSRKDAFFK------------NYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTG-KGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYL--FSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYN-GTNCEDCLRV-SPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGI--YHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF----------EIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST--AIGSLSASNRLVCTFQMMK-----VLQKASIKCSMKVSWILGNLLTGS------IETETPIEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKC-----KIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIY-ENCFVNNSD-IDCISPTTSNITQ---FQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIK--QKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQV--IENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDS--ELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPA---------------CLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGT 5731
E +FP + G+ D R ++K +Y +F+ Q N + + Q RLVR+C+ D ++ S+ ++ + C T V +V +V A + K+ + D + + + K N+YR E C + + EI + C G+ + +N F S D C FT+ +G GK+ N I GD S + + + I + T+A +G G L+K L E ++TE L +N I +M + +Y + SK+I+ C T C+ CL P+CGWC+SN C ++ C T+ WL FQ ++ CP I + I + V + + P + ++C F + + + + + SL C P +P I N+ + KL V+ + S L + Y+C +C+ C ++F C WC+ N C++ L KC+K I+ CP + +S G +I + +N F DF C T I ++ + + C + + +L S V W G ++ + V+ C L+ +C C+ L Y CG+C++ KC + H C N W+N+ Q CP P I + P ++ + + + G NLG + +DV+ A+ + N C+ +E Y+ S++ C I+ N+R VA + + + S E F + P V S++P GP GGT + + G L+ G+ V+F I C ILE ++ CR+ S + L + D + FEF +P V+ IS NK + +GG + G L +P + F Y C + + + C +PT Q+ +A + +Y + I + +P +S P R ++ + +T+N + ++++A + D + VG C + + C Q + L + V+TV G F G++S D+ + + +++ I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN H ++ N ++ E R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V S ++ V VLDCD I+Q K K + Y+ +++ + +++ K+ ++ S R+ + L TL Y++ + + + K+ SL N + S +AS+ +++S S + P ++D H +SS + + FK H +KP L ++K + I +L + IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I T
Sbjct: 204 EVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIAD--DSSIQSRLVRVCTGDKNFHSYTEVPLEC------TQNGVEFNLVQDVYVTRAGYELAKSLDISVS---DPVLYGVFWEGDK-----NSYRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDD-CR---FTTLPWEGIKCGKDVNSKIGGDTPISTSAT---YVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKI-LIESKRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSK----CPRIRSVKPDQIQINTADYLNVTIENLQAP------KGRRMQCLFQFSTGDAVVSDPMPF---DGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDATFMG--DFKCEFKYGTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNAS-QLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIAN----VPCEVVE--YVPSQKIVCVTGKSPIKGSNER--GVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQ----IGCKILERASGWLRCRMG------------ASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFET----LSEP----RFVRPGEDFLTLN---GNHLNLAA-SERDIDVKVGGEPCPLTALANKVLTC------QPPVKKPRGAGKLNPEIVVTV-GNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNAGK---------------------------NHAVLKNLEVDTHKAEAIEAGLREFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSL--YNLVNFSSTSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIAD--HASSSADTD---------NGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDIQ--KPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMT 1856
BLAST of plexin A vs. Ensembl Celegans
Match: plx-1 (PLeXin [Source:UniProtKB/TrEMBL;Acc:U4PC90]) HSP 1 Score: 287.345 bits (734), Expect = 8.038e-78 Identity = 411/1791 (22.95%), Postives = 719/1791 (40.15%), Query Frame = 2
Query: 725 ETIFPLEFVGSFHIYDSRKDAFFK------------NYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTS-TGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYL--FSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYN-GTNCEDCLRV-SPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGI--YHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF----------EIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST--AIGSLSASNRLVCTFQMMK-----VLQKASIKCSMKVSWILGNLLTGS------IETETPIEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKC-----KIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIY-ENCFVNNSD-IDCISPTTSNITQ---FQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIK--QKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQV--IENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDS--ELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPA---------------CLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGT 5731
E +FP + G+ D R ++K +Y +F+ Q N + + Q RLVR+C+ D ++ S+ ++ + C T V +V +V A + K+ + D + + + K N+YR E C + + EI + C G+ + +N F S D C FT+ +G GK+ N I GD S + + + I + T+A +G G L+K L E ++TE L +N I +M + +Y + SK+I+ C T C+ CL P+CGWC+SN C ++ C T+ WL FQ ++ CP I + I + V + + P + ++C F + + + + + SL C P +P I N+ + KL V+ + S L + Y+C +C+ C ++F C WC+ N C++ L KC+K I+ CP + +S G +I + +N F DF C T I ++ + + C + + +L S V W G ++ + V+ C L+ +C C+ L Y CG+C++ KC + H C N W+N+ Q CP P I + P ++ + + + G NLG + +DV+ A+ + N C+ +E Y+ S++ C I+ N+R VA + + + S E F + P V S++P GP GGT + + G L+ G+ V+F I C ILE ++ CR+ S + L + D + FEF +P V+ IS NK + +GG + G L +P + F Y C + + + C +PT Q+ +A + +Y + I + +P +S P R ++ + +T+N + ++++A + D + VG C + + C Q + L + V+TV G F G++S D+ + + +++ I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN H ++ N ++ E R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V S ++ V VLDCD I+Q K K + Y+ +++ + +++ K+ ++ S R+ + L TL Y++ + + + K+ SL + S E +S S+KT P + P + +++S + + FK H +KP L ++K + I +L + IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I T
Sbjct: 15 EVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIAD--DSSIQSRLVRVCTGDKNFHSYTEVPLEC------TQNGVEFNLVQDVYVTRAGYELAKSLDISVS---DPVLYGVFWEGDK-----NSYRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDD-CR---FTTLPWEGIKCGKDVNSKIGGDTPISTSAT---YVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKI-LIESKRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSK----CPRIRSVKPDQIQINTADYLNVTIENLQAP------KGRRMQCLFQFSTGDAVVSDPMPF---DGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDATFMG--DFKCEFKYGTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNAS-QLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIAN----VPCEVVE--YVPSQKIVCVTGKSPIKGSNER--GVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQ----IGCKILERASGWLRCRMG------------ASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFET----LSEP----RFVRPGEDFLTLN---GNHLNLAA-SERDIDVKVGGEPCPLTALANKVLTC------QPPVKKPRGAGKLNPEIVVTV-GNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNAGK---------------------------NHAVLKNLEVDTHKAEAIEAGLREFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSLYNLSILS-DRSEKSSVSMKT----------------PGVGSPKPWGAPPSVIADHASSSADTD-------NGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDI--QKPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMT 1656
BLAST of plexin A vs. Ensembl Celegans
Match: plx-1 (PLeXin [Source:UniProtKB/TrEMBL;Acc:U4PC90]) HSP 1 Score: 286.96 bits (733), Expect = 1.488e-77 Identity = 411/1791 (22.95%), Postives = 719/1791 (40.15%), Query Frame = 2
Query: 725 ETIFPLEFVGSFHIYDSRKDAFFK------------NYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTS-TGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYL--FSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYN-GTNCEDCLRV-SPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGI--YHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF----------EIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST--AIGSLSASNRLVCTFQMMK-----VLQKASIKCSMKVSWILGNLLTGS------IETETPIEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKC-----KIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIY-ENCFVNNSD-IDCISPTTSNITQ---FQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIK--QKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQV--IENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDS--ELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPA---------------CLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGT 5731
E +FP + G+ D R ++K +Y +F+ Q N + + Q RLVR+C+ D ++ S+ ++ + C T V +V +V A + K+ + D + + + K N+YR E C + + EI + C G+ + +N F S D C FT+ +G GK+ N I GD S + + + I + T+A +G G L+K L E ++TE L +N I +M + +Y + SK+I+ C T C+ CL P+CGWC+SN C ++ C T+ WL FQ ++ CP I + I + V + + P + ++C F + + + + + SL C P +P I N+ + KL V+ + S L + Y+C +C+ C ++F C WC+ N C++ L KC+K I+ CP + +S G +I + +N F DF C T I ++ + + C + + +L S V W G ++ + V+ C L+ +C C+ L Y CG+C++ KC + H C N W+N+ Q CP P I + P ++ + + + G NLG + +DV+ A+ + N C+ +E Y+ S++ C I+ N+R VA + + + S E F + P V S++P GP GGT + + G L+ G+ V+F I C ILE ++ CR+ S + L + D + FEF +P V+ IS NK + +GG + G L +P + F Y C + + + C +PT Q+ +A + +Y + I + +P +S P R ++ + +T+N + ++++A + D + VG C + + C Q + L + V+TV G F G++S D+ + + +++ I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN H ++ N ++ E R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V S ++ V VLDCD I+Q K K + Y+ +++ + +++ K+ ++ S R+ + L TL Y++ + + + K+ SL + S E +S S+KT P + P + +++S + + FK H +KP L ++K + I +L + IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I T
Sbjct: 204 EVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIAD--DSSIQSRLVRVCTGDKNFHSYTEVPLEC------TQNGVEFNLVQDVYVTRAGYELAKSLDISVS---DPVLYGVFWEGDK-----NSYRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDD-CR---FTTLPWEGIKCGKDVNSKIGGDTPISTSAT---YVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKI-LIESKRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSK----CPRIRSVKPDQIQINTADYLNVTIENLQAP------KGRRMQCLFQFSTGDAVVSDPMPF---DGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDATFMG--DFKCEFKYGTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNAS-QLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIAN----VPCEVVE--YVPSQKIVCVTGKSPIKGSNER--GVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQ----IGCKILERASGWLRCRMG------------ASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFET----LSEP----RFVRPGEDFLTLN---GNHLNLAA-SERDIDVKVGGEPCPLTALANKVLTC------QPPVKKPRGAGKLNPEIVVTV-GNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNAGK---------------------------NHAVLKNLEVDTHKAEAIEAGLREFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSLYNLSILS-DRSEKSSVSMKT----------------PGVGSPKPWGAPPSVIADHASSSADTD-------NGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDIQ--KPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMT 1845
BLAST of plexin A vs. Ensembl Celegans
Match: plx-1 (PLeXin [Source:UniProtKB/TrEMBL;Acc:U4PC90]) HSP 1 Score: 197.208 bits (500), Expect = 2.136e-50 Identity = 271/1142 (23.73%), Postives = 481/1142 (42.12%), Query Frame = 2
Query: 2519 IEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKC-----KIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIY-ENCFVNNSD-IDCISPTTSNITQ---FQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIK--QKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQI-----QVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDS--ELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPA---------------CLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGT 5731
+ V+ C L+ +C C+ L Y CG+C++ KC + H C N W+N+ Q CP P I + P ++ + + + G NLG + +DV+ A+ + N C+ +E Y+ S++ C I+ N+R VA + + + S E F + P V S++P GP GGT + + G L+ G+ V+F I C ILE ++ CR+ S + L + D + FEF +P V+ IS NK + +GG + G L +P + F Y C + + + C +PT Q+ +A + +Y + I + +P +S P R ++ + +T+N + ++++A + D + VG C + + C Q + L + V+TV G F G++S D+ + + +++ I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN H ++ N ++ + IE + R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V S ++ V VLDCD I+Q K K + Y+ +++ + +++ K+ ++ S R+ + L TL Y++ + + + K+ SL N + S +AS+ +++S S + P ++D H +SS + + FK H +KP L ++K + I +L + IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I T
Sbjct: 46 LAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQCSNRQIPENWLNAS-QLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIAN----VPCEVVE--YVPSQKIVCVTGKSPIKGSNER--GVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQ----IGCKILERASGWLRCRMG------------ASGEGGQFPLHIAFDGQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQERITEYAFDFDGAELYRSRIKVMPSPTFET----LSEP----RFVRPGEDFLTLN---GNHLNLAA-SERDIDVKVGGEPCPLTALANKVLTC------QPPVKKPRGAGKLNPEIVVTV-GNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNAGK---------------------------NHAVLKNLEVDTHKAEAIEAGL---REFHKLLMNKTFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGKMALQDIDSSSRVEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSL--YNLVNFSSTSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIAD--HASSSADTD---------NGFKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFSSSTVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDI--QKPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMT 1085
BLAST of plexin A vs. Ensembl Fly
Match: PlexA (gene:FBgn0025741 transcript:FBtr0089223) HSP 1 Score: 295.819 bits (756), Expect = 3.808e-80 Identity = 440/1961 (22.44%), Postives = 794/1961 (40.49%), Query Frame = 2
Query: 206 ILVSGKNYILQFSEN-NLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVF--VKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSI-LSFPNMTYFKPDYPFQANFG----KL--VYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIF---------FLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWT--YYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDT---NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAM-----WLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLI-NDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQN---------NQPD-CPTLEVSNETLSFHVGFPISIGLMTK-NFRNYFNSKTDFVCLETCDNS-TAIGSLSASNRLVC-TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICG-NDDSK--WINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKN--------KFLSNGGQMFKITGDNLNRLNKPS--VAFRCETFLSIYENCFV-NNSDIDCISPTT---SNITQFQKCSLL---FAME-----KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNII-EVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLD---NMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLR--HEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXX-----------XNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHL-KPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIK 5725
+ V G N + Q S + L E + KTGP N SV +C CP + TD + V L A S L+ C +FQG C + +L N S ++V ND STV + HP N M + +++ N + ++ + P A+ K+ + T F+ S+ ++ +F NY++ FL Q ++ H + +LVRIC D +Y S+ +I + C D Q + V + + S D+A + + D +F + TNN C Y + I + C GSG +F S C+ + G+ CG + G + I ++ + S+ S +T+ +G +DG L K + + Y +L + I+ +M + IY ++ +K+ + + +C + C DCL P+CGWC KC + C W+ + +T K + +V+P H + + ++ +I L L EN L C FT+ + N + ++C P +P I + K+ KL V N LV + ++C+ +C CV+++F C WCV + C + C+ + + + P CPT+ + + V S + K + F +T FVC + T++ + + + C + + + ++ + V W GS + P I ++ C ++++ C C+ L + Y CG+C+ + C + C N + K W+N + + CP P I P + I ++G NLG ND+ + + + C Q YI +KQ C + + +++ + + D SKE ++F P++ P FGP GGT I + G LN GSR + N +++ C++ + + R S + L+++ D +F D F++ +P V+ +S K + GG +TG + P+ V + E + S C V ++++++C SP S++ + ++ LL F M+ + V+N ++ P I ++ + K + +TIN D+ A +SD ++ +G C S + C E + ++ + +G ++ G + +E +I LD N+ +I I+++++ + L+V K +S + LR E+ +I ++ E E AEL P Y Y + LFPN + + + P ++ K+ + R +L ++ F+L+F LE ++ + + ++ S + + L L T ILK L+ + +K + + + + R + K+LS WF L+Y L+ AG L +L+ + ++ GPV+ T +++Y+L+E L+ + I+F+ + + + + V+VLDCD I Q K K E IY+ P S W + + +I ++D ++E L TL+ Y++ DG + + K S+ + S L + ++ NISK TS P S+ L++ +HEN + + + + + K+G + K IY T++L +K G ++ DD+F+ ++PL + +F ++ + D +V KSNSL LRFW+ LI N +F+FD+ K V CL V++ MD CS + + KD ++ L++ I Y V YY I+
Sbjct: 87 VFVGGVNRLYQLSPDLELSETV---KTGPQNDSV------ECSILDCPLNAVRSP------TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQN-VSIIEHEVPDAVVANDAN-SSTVAF-----IAPGPPQHPVT------NVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSY-----ARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQ---------SLGISIQDDVLFAVFSKGEGNTPTNNS-------ALCIYSLKSIRRKFMQNIKSCFNGSGMRG---LDFISPSMPCVLTKLQTIGEDFCG------LDVNSPLGGETPITSVPVAMFNTKLTSVAATST-SGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSY---KTGKCTTITSVVP-HQLQRTTARTLELIID----HLPQLKEN---LICAFTTEDKALFTNATKK----RNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIW------GGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLN-RSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG----INCMPFPQFYIDTKQIVCTVDSPGEQMYR--NGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIN---------------DHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYAS---PCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERV-------KYFKSEYLTINGRNLDR----ACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF----AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ---------------------WERPELLRKEKGL--------RIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKEC-AGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWK----------KLNTLQHYNVPDGAGLSLVPKQSSI-----YNFSILSDKNEKSHKYETLNISK---YTSSSPTFSR--AGSPLNNDMHENGLRYWHLVKHHDSDMQ--KEGERVNKLVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIH--KSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIR 1871
BLAST of plexin A vs. Ensembl Fly
Match: PlexA (gene:FBgn0025741 transcript:FBtr0309865) HSP 1 Score: 288.115 bits (736), Expect = 8.460e-78 Identity = 436/1961 (22.23%), Postives = 788/1961 (40.18%), Query Frame = 2
Query: 206 ILVSGKNYILQFSEN-NLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVF--VKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSI-LSFPNMTYFKPDYPFQANFG----KL--VYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIF---------FLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWT--YYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDT---NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAM-----WLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLI-NDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQN---------NQPD-CPTLEVSNETLSFHVGFPISIGLMTK-NFRNYFNSKTDFVCLETCDNS-TAIGSLSASNRLVC-TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICG-NDDSK--WINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKN--------KFLSNGGQMFKITGDNLNRLNKPS--VAFRCETFLSIYENCFV-NNSDIDCISPTT---SNITQFQKCSLL---FAME-----KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNII-EVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLD---NMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLR--HEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXX-----------XNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHL-KPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIK 5725
+ V G N + Q S + L E + KTGP N SV +C CP + TD + V L A S L+ C +FQG C + +L N S ++V ND STV + HP N M + +++ N + ++ + P A+ K+ + T F+ S+ ++ +F NY++ FL Q ++ H + +LVRIC D +Y S+ +I + C D Q + V + + S D+A + + D +F + TNN C Y + I + C GSG +F S C+ + G+ CG + G + I ++ + S+ S +T+ +G +DG L K + + Y +L + I+ +M + IY ++ +K+ + + +C + C DCL P+CGWC KC + C W+ + +T K + +V+P H + + ++ +I L L EN L C FT+ + N + ++C P +P I + K+ KL V N LV + ++C+ +C CV+++F C WCV + C + C+ + + + P CPT+ + + V S + K + F +T FVC + T++ + + + C + + + ++ + V W GS + P I ++ C ++++ C C+ L + Y CG+C+ + C + C N + K W+N + + CP P I P + I ++G NLG ND+ + + + C Q YI +KQ C + + +++ + + D SKE ++F P++ P FGP GGT I + G LN GSR + N +++ C++ + + R S + L+++ D +F D F++ +P V+ +S K + GG +TG + P+ V + E + S C V ++++++C SP S++ + ++ LL F M+ + V+N ++ P I ++ + K + +TIN D+ A +SD ++ +G C S + C E + ++ + +G ++ G + +E +I LD N+ +I I+++++ + L+V K +S + LR E+ +I ++ E E AEL P Y Y + LFPN + + + P ++ K+ + R +L ++ F+L+F LE ++ + + ++ S + + L L T ILK L+ + +K + + + + R + K+LS WF L+Y L+ AG L +L+ + ++ GPV+ T +++Y+L+E L+ + I+F+ + + + + V+VLDCD I Q K K E IY+ P S W + + +I ++D ++E L TL+ Y++ DG + + K S+ N + +S K KS N + L++ +HEN + + + + + K+G + K IY T++L +K G ++ DD+F+ ++PL + +F ++ + D +V KSNSL LRFW+ LI N +F+FD+ K V CL V++ MD CS + + KD ++ L++ I Y V YY I+
Sbjct: 87 VFVGGVNRLYQLSPDLELSETV---KTGPQNDSV------ECSILDCPLNAVRSP------TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQN-VSIIEHEVPDAVVANDAN-SSTVAF-----IAPGPPQHPVT------NVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSY-----ARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQ---------SLGISIQDDVLFAVFSKGEGNTPTNNS-------ALCIYSLKSIRRKFMQNIKSCFNGSGMRG---LDFISPSMPCVLTKLQTIGEDFCG------LDVNSPLGGETPITSVPVAMFNTKLTSVAATST-SGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSY---KTGKCTTITSVVP-HQLQRTTARTLELIID----HLPQLKEN---LICAFTTEDKALFTNATKK----RNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIW------GGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLN-RSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG----INCMPFPQFYIDTKQIVCTVDSPGEQMYR--NGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIN---------------DHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYAS---PCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERV-------KYFKSEYLTINGRNLDR----ACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF----AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ---------------------WERPELLRKEKGL--------RIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKEC-AGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWK----------KLNTLQHYNVPDGAGLSLVPKQSSI--YNFSILSD--------KNEKSHNRAGS-----------------PLNNDMHENGLRYWHLVKHHDSDMQ--KEGERVNKLVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIH--KSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIR 1854
BLAST of plexin A vs. Ensembl Fly
Match: PlexA (gene:FBgn0025741 transcript:FBtr0089224) HSP 1 Score: 264.233 bits (674), Expect = 8.828e-71 Identity = 344/1532 (22.45%), Postives = 639/1532 (41.71%), Query Frame = 2
Query: 1430 FTLAMIGGNDGILYKYELFEDT---NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAM-----WLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLI-NDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQN---------NQPD-CPTLEVSNETLSFHVGFPISIGLMTK-NFRNYFNSKTDFVCLETCDNS-TAIGSLSASNRLVC-TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKN--------KFLSNGGQMFKITGDNLNRLNKPS--VAFRCETFLSIYENCFV-NNSDIDCISPTT---SNITQFQKCSLL---FAME-----KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNII-EVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLD---NMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLR--HEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXX-----------XNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHL-KPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIK 5725
+T+ +G +DG L K + + Y +L + I+ +M + IY ++ +K+ + + +C + C DCL P+CGWC KC + C W+ + +T K + +V+P H + + ++ +I L L EN L C FT+ + N + ++C P +P I + K+ KL V N LV + ++C+ +C CV+++F C WCV + C + C+ + + + P CPT+ + + V S + K + F +T FVC + T++ + + + C + + + ++ + V W GS + P I ++ C ++++ C C+ L + Y CG+C+ + C + C + + W+N + + CP P I P + I ++G NLG ND+ + + + C Q YI +KQ C + + +++ + + D SKE ++F P++ P FGP GGT I + G LN GSR + N +++ C++ + + R S + L+++ D +F D F++ +P V+ +S K + GG +TG + P+ V + E + S C V ++++++C SP S++ + ++ LL F M+ + V+N ++ P I ++ + K + +TIN D+ A +SD ++ +G C S + C E + ++ + +G ++ G + +E +I LD N+ +I I+++++ + L+V K +S + LR E+ +I ++ E E AEL P Y Y + LFPN + + + P ++ K+ + R +L ++ F+L+F LE ++ + + ++ S + + L L T ILK L+ + +K + + + + R + K+LS WF L+Y L+ AG L +L+ + ++ GPV+ T +++Y+L+E L+ + I+F+ + + + + V+VLDCD I Q K K E IY+ P S W + + +I ++D ++E L TL+ Y++ DG + + K S+ + S L + ++ NISK TS P S+ L++ +HEN + + + + + K+G + K IY T++L +K G ++ DD+F+ ++PL + +F ++ + D +V KSNSL LRFW+ LI N +F+FD+ K V CL V++ MD CS + + KD ++ L++ I Y V YY I+
Sbjct: 17 YTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSY---KTGKCTTITSVVP-HQLQRTTARTLELIID----HLPQLKEN---LICAFTTEDKALFTNATKK----RNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIW------GGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLN-RSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG----INCMPFPQFYIDTKQIVCTVDSPGEQMYR--NGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIN---------------DHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYAS---PCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERV-------KYFKSEYLTINGRNLDR----ACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF----AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ---------------------WERPELLRKEKGL--------RIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKEC-AGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWK----------KLNTLQHYNVPDGAGLSLVPKQSSI-----YNFSILSDKNEKSHKYETLNISK---YTSSSPTFSR--AGSPLNNDMHENGLRYWHLVKHHDSDMQ--KEGERVNKLVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIH--KSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIR 1431
BLAST of plexin A vs. Ensembl Fly
Match: PlexA (gene:FBgn0025741 transcript:FBtr0089225) HSP 1 Score: 264.233 bits (674), Expect = 8.828e-71 Identity = 344/1532 (22.45%), Postives = 639/1532 (41.71%), Query Frame = 2
Query: 1430 FTLAMIGGNDGILYKYELFEDT---NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAM-----WLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLI-NDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQN---------NQPD-CPTLEVSNETLSFHVGFPISIGLMTK-NFRNYFNSKTDFVCLETCDNS-TAIGSLSASNRLVC-TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKN--------KFLSNGGQMFKITGDNLNRLNKPS--VAFRCETFLSIYENCFV-NNSDIDCISPTT---SNITQFQKCSLL---FAME-----KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNII-EVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLD---NMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLR--HEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXX-----------XNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHL-KPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIK 5725
+T+ +G +DG L K + + Y +L + I+ +M + IY ++ +K+ + + +C + C DCL P+CGWC KC + C W+ + +T K + +V+P H + + ++ +I L L EN L C FT+ + N + ++C P +P I + K+ KL V N LV + ++C+ +C CV+++F C WCV + C + C+ + + + P CPT+ + + V S + K + F +T FVC + T++ + + + C + + + ++ + V W GS + P I ++ C ++++ C C+ L + Y CG+C+ + C + C + + W+N + + CP P I P + I ++G NLG ND+ + + + C Q YI +KQ C + + +++ + + D SKE ++F P++ P FGP GGT I + G LN GSR + N +++ C++ + + R S + L+++ D +F D F++ +P V+ +S K + GG +TG + P+ V + E + S C V ++++++C SP S++ + ++ LL F M+ + V+N ++ P I ++ + K + +TIN D+ A +SD ++ +G C S + C E + ++ + +G ++ G + +E +I LD N+ +I I+++++ + L+V K +S + LR E+ +I ++ E E AEL P Y Y + LFPN + + + P ++ K+ + R +L ++ F+L+F LE ++ + + ++ S + + L L T ILK L+ + +K + + + + R + K+LS WF L+Y L+ AG L +L+ + ++ GPV+ T +++Y+L+E L+ + I+F+ + + + + V+VLDCD I Q K K E IY+ P S W + + +I ++D ++E L TL+ Y++ DG + + K S+ + S L + ++ NISK TS P S+ L++ +HEN + + + + + K+G + K IY T++L +K G ++ DD+F+ ++PL + +F ++ + D +V KSNSL LRFW+ LI N +F+FD+ K V CL V++ MD CS + + KD ++ L++ I Y V YY I+
Sbjct: 17 YTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSY---KTGKCTTITSVVP-HQLQRTTARTLELIID----HLPQLKEN---LICAFTTEDKALFTNATKK----RNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIW------GGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLN-RSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG----INCMPFPQFYIDTKQIVCTVDSPGEQMYR--NGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIN---------------DHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYAS---PCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERV-------KYFKSEYLTINGRNLDR----ACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF----AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ---------------------WERPELLRKEKGL--------RIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKEC-AGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWK----------KLNTLQHYNVPDGAGLSLVPKQSSI-----YNFSILSDKNEKSHKYETLNISK---YTSSSPTFSR--AGSPLNNDMHENGLRYWHLVKHHDSDMQ--KEGERVNKLVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIH--KSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIR 1431
BLAST of plexin A vs. Ensembl Fly
Match: PlexB (gene:FBgn0025740 transcript:FBtr0308297) HSP 1 Score: 180.259 bits (456), Expect = 8.963e-45 Identity = 259/1167 (22.19%), Postives = 452/1167 (38.73%), Query Frame = 2
Query: 197 HKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFA---DSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLYHDQR--------LFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCD-IDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKS---TDKRCMEDGFTSTGKGECGGKNFNKFIIGDHY-GENSIIGHRVIS-RNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDT--NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSE------------NDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSA---SNRLVCTFQM--MKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEH-----CDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWINSKFQ-KCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITL-----ENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSI--------QFTDVQFEFFP-----------NPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSD-IDCISP 3478
H + N IL+ +EN LA TGP++ S QC CP+++ L + F K+ + D L+ C + QG CEI L +F ++ + A + ND + R L+ + +YR D +S ++ Y ++ Q + + + + F ++++ F+ + Y +F++ Q + H + RL RIC D +Y S+ +I + C +N Y V V S +A K + D H +L F +N E+ ++ C Y I +I +++ + N+ L +G+ + + S D RC G G +N +G G + I H + N + ++ +LA +G N G++ K L + Y + N I N +++ K +Y ++ KI + + +C TNC CL PFCGWC +C V+ C R A +++ +E+ + P K P+S LS N K+ +C F ++ + I + L C P P I N + + + L V ++++ V + ++C+H C C+ + + C+WC+ DN C+ SL +C+ + CP L+ + + V PI I L +N ++ F+C T A L A SN++V + + + + V+W + + +I T ++ C L H C CV YKC +C+ + CV C D S S + +CPLP I I P + + ++I ++G NLG E DV+ I + E ++Q K ++ S + I+ ND T + QF FK + + + P GP GGT + + G FLNIGS + I ++ + + +SC ++ + + + +L+ I SI F Q P +P + +I + +GG++ + G LN + KP + + +C V NS+ ++C SP
Sbjct: 96 HNVLFAGATNKILKLNEN--LRVLAEAVTGPLHDS------PQCHAGGCPEDI------ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSL-PRFPATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRH-DVPAISSRRLDDLNY--AEFSIQQSIINIDVKYRDH-FLVDYIYGFNSSE---------YAYFIIVQ-KKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQ-----------KMGIKKDDH-VLVTVFSPSREISNQPESKSAM--CIYSIKDIEDMF--IENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSL--------GNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTC----------QRDTSASRWLSLGSGQQCIEFESIIP------EKIPISELSHLHLIIRTLPEPFNAKY-RCVFGNSTPIDAE-------ILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSL-QCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLC--TIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVT-------LYKCDVLGSHREHPDCSLCVTRDPKYKCAWCS--NSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFK--------------NVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHI--DVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSP 1157 HSP 2 Score: 95.5153 bits (236), Expect = 4.507e-19 Identity = 210/937 (22.41%), Postives = 393/937 (41.94%), Query Frame = 2
Query: 2990 PRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFK----RSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSI---TIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRC-----NIIEVNQIDIYHKYQISLLM---GKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEAN--EVLKRGIAELNQAAIQDEIHKNWNTA-PIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKL---SKLFEDELFVLMFFSFLEDHQEVES--KKSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYS----------NWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGY-TLKTLKDYDIKDGDNICVAMK---NESLPASNTASVSHLES----NSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
PR+ I+P GG ++ V+G +LN + E++ Y + N+ + + N E + +K + +N +K +L++ +S Q T+ +++ N + +K + F GD FR T N FVNN ++D + + TQ L F M+ + V N + I ST V +P + P + +++ K + I E+ + A + D + +G C S N + C + ++ + + L++ G+N+ V GY++++ + + ++++ I + +++ + ++V++I +K +R E + I + I E+N K+ AEL Q + D +T P ++ YI+ FP HP++ + + + Y + +L ++ F+LMF LE + S + ++ S + ++LM + T ILK L+ DK ++ + M R+++ ++ K+L+N+ I MYD+L+ AG +L +L+ I + I G V+ T+ ++Y+L+E LL ++ + L + + D ++ V D D ISQ KLKI + I+K +P+S W L ++D + K V G+ L TL Y +K+ + + + N +P S + + + N++ + +I + + IP H ++ +NS ++ D + + T++L +K G I+ DD F E +P V LF + + D IV A KSN L LRFW+ I N DF+FDV K V CL +++ MD CS ++++
Sbjct: 1097 PRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERV------NKTSCVVINSNQMECPSPPVNYKFETFKKTN-RKMDTELHLQNSSFQ-TETRYK---NEYDRKKRRADF-----------GD----------TFRLYTNAGSSANYFVNN-NMDVTTFVKVHETQLN-LQLSFVMDNVQL-VRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNL----AADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAER---EYKRIQIQMITLESNVRSECKQAFAEL-QTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVS----------------------------DHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEY-AGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDL--DEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDED-----------LTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNI---KNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATK--GTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVN--KTYSVDSCLSVIAQTFMDACSTSEHR 1941
BLAST of plexin A vs. Ensembl Zebrafish
Match: plxna1a (plexin A1a [Source:ZFIN;Acc:ZDB-GENE-140106-137]) HSP 1 Score: 268.855 bits (686), Expect = 7.986e-72 Identity = 332/1486 (22.34%), Postives = 625/1486 (42.06%), Query Frame = 2
Query: 1394 GYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENLF----NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAEN---KNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIND-RIETPVAFQFKFKTKD-----KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSNI------TQFQKCSLLFAMEK-GSVCVYNTSITIFSTPVLR-INPNKI--SLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTV-SGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
G + + Y T+A G G + K + T EN+ + I +M+ + + IY +AD ++ R + +C ++C +CL P CGWC+ + C KD+C A P + ++ C + V P++ + S ++ Q P N C F + + H I + C+ P + I PI N K V L LK + YNC+ ++C CVN F C WC + C ++ C N +CP + S + + VG I L+ +N + + ++ C+ TA+ S S + T + + + + V W G + P I+ ++ C + + C C+ + CG+C + KC + C +S W+N +C P I ++ P + + + G NLG D+ + L + C IE+ Y+S+++ C + + R++ Q + +D + L + F F +P ++P GP GGT I + G+ LN GS V N G P C K+ + N + ++ID+ ++ +V+F + +P V KI + +++GG + I+G NL + +P + + + S + NC V NNS + C++P+ ++ T + F M+ ++ V N S + + P+ ++P I PT+ L I+K + + N ++ ++ +F+G C ++ +++ + ++ L G++ +T+ +G ++ G + + + S++ + I+ + +L++VII + K++ R + +++ + + + R E + A +Q +IH+ + P Y Y + LFP HP++ +++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L +LY + + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD I+Q K K+ + +YK SPYS K ++ + LA I L++ T L +L Y + DG I V +N + SN+++ + L + L+T S + + PM + PD+ + L + H+++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 431 GMTSVAAYDYRGQTVAFTGTRSGRMKKILVNSITQPALLYENVVVSEGSPILRDMLFSPDHQYIYTLADKEVKRVPVESCSQYSSCGECLASGDPHCGWCVLHSVCSRKDRCERADE-PQRFASRLEQCVRLTVQPNNISVTMSEVQ--LVLQAQNVPSLAAGVN-----CSF-----EDFTETEGH--IMGGRIYCLSPSTREISPITRNQGDKRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHMCTHNA-NDCSFQEGRVNMSEECPQILPSTQ-IYIPVGVMKPITLLARNLPQPQSGQRNYECIFYIQGKEYSVTALRFNSTSIQCQKTMYDYEGNDISDLPVDLSVVW------NGDFVIDNPYNIQAHLYKCFAMRDSCGMCLKADPRFDCGWCVQEKKCSLRQECAPPESSWMNPSAGNSRCAHPKINKLFPETGPRQGGTRLTITGENLGLQFRDIMTGVRLG----KVPCIPIEEEYVSAERIVCLLNDATGYRVQEA---QVEVCVRDCVADYRALSPRAFTFVTPYFARVQPAQGPLSGGTRITIEGNHLNAGS--SVAVNIGRHP--------------CHFKKRSSKEIVCVTPAGVNAVSTPVMVDIDSAELRNPEVKFNYTDDPTVLKIDPDWSIASGGTLLTISGTNLATIKEPKIRAKYGSAES-FHNCTVFNNSVMVCLAPSVADSERGFAETGSGPDEIGFYMDNVHALVVVNESFSYYPDPIFEPLSPTGILELKPTSPL-ILKGRNLIPAAPGNSRL--------NYTVFIGETPC-------------VLTLSETQLLCEW--PNLTGQHKVTIRAGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIAVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVLKEMEVRVQANVEKALTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAMKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVNPENENGPEVTVKCLNCDTITQVKEKLLDAVYKGSPYSQRP--------KAGDMDLEWRQGRLARIILQDEDVTTKIDNDWKRLNSLAHYQVTDGSVIALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHADQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1785
BLAST of plexin A vs. Ensembl Zebrafish
Match: plxna2 (plexin A2 [Source:ZFIN;Acc:ZDB-GENE-090311-6]) HSP 1 Score: 206.068 bits (523), Expect = 1.359e-52 Identity = 251/1141 (22.00%), Postives = 448/1141 (39.26%), Query Frame = 2
Query: 188 NKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAYSIVTNDRKFHSTVLY----HDQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHE------PKNGLFQV-RLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENL-----FNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNF--VDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN-DRIETPVAFQF-KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDV-QFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
+K+ ++ + N + + S N L TGP + + C P Q C + LIS + L L ++ + L+ C ++QG C+++ DL+ S+K + Y N V+ D LF V +Y F T+S P + DY +F L+ +T+ + ++IY N+++FL QPE P N LF R+VR+C D + S++ + + C + N+ Y + + + A + + D +LF F Y + C + I +I C G G++ N D C ++D F G + N+ + G + GH + + + + S+ + +Y F +A +G G L K + E L N+I +M + + S IY +++ ++ R + +C + C +CL P CGWC+ + C +D+C A P++ T+ C V P + P+V V T + LS + C F N E+ ++ + + CI P K++P I ++++ V+L+L L+ YNC+ + C CV + F C WC N C C N DCP L S E L G I L +N + + + C+ TA+ S+S + + + + ++ + + V W GN + I+ I+ ++ C + C C+ + ++CG+C+++ +C + C + S+W++ S KC P I E+ P + + ++G NLG +D+ N + + C E YI ++Q C++ D PV + K + + S+ + F P V + P+ GP GGT + + G L GS V F T C E I C + S S+Q+++ + Q D+ FE+ +P V++I +++G +TG NL+ + +P + + S+ +N + + C +P+
Sbjct: 59 HKTTGALYIGAVNRVYKLSGNLTL--LVSHDTGPEDDNKACYPPLIVQP--CSEPLISTNNINKLL------LIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGKDGTLFIGTAVDGKQDY----FPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYIYGFASG----NFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGC-VRNRVEYRLLQAAYLGKPGRVFA---------ASLNISAQDD---VLFAVFS--KGQKQYHHPPDDSALCVFSIRDINARIKERMQSCYQGEGNLELN--WLLGKDVPCTKAPVPIDDSFC--------GLDINQPLGGSQL----VTGHTLYTESRDRMTSVTSY-VYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKDGNSILRDMAFSLDNSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRCERANE-PYRFAATLNQCVKATVYPD----SIAVSEPSVPLLVKVTDVPDLSAG---ITCSF--GNLTEVEG-----RVNGNQILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWCKYRNLCTHDP-SSCSFQEGRVNASEDCPQLVRSEEIL-IPAGEVKPITLKARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMRISELPVDFSVVWN-GNFI---IDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRWLHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQ----CTPQENGYIIAEQIVCEMDAAPVDSKAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVTIMGENLGAGSSVTVLFGNQT----CEFYERTMTEIVC-------------YSAPSLTGVGSVQISVSVDRAQVRDILAFEYIDDPTVQRIEPEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLNTTTMSCFAPS 1109 HSP 2 Score: 105.531 bits (262), Expect = 6.341e-22 Identity = 122/486 (25.10%), Postives = 226/486 (46.50%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENT---VEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ ++++V N VE + KL ++L +++F+L F LE + + + ++ S + L L T +LK L+ + DK + N + + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS K ++ + +A + L++ T L TL Y + D + + K S +P + + S + + ++ + T ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS ++++
Sbjct: 1340 HPVL--RELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLILNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRP--------KAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTSISRYDSTFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHR 1796
BLAST of plexin A vs. Ensembl Zebrafish
Match: plxna2 (plexin A2 [Source:ZFIN;Acc:ZDB-GENE-090311-6]) HSP 1 Score: 206.068 bits (523), Expect = 1.359e-52 Identity = 251/1141 (22.00%), Postives = 448/1141 (39.26%), Query Frame = 2
Query: 188 NKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAYSIVTNDRKFHSTVLY----HDQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHE------PKNGLFQV-RLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENL-----FNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNF--VDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN-DRIETPVAFQF-KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDV-QFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
+K+ ++ + N + + S N L TGP + + C P Q C + LIS + L L ++ + L+ C ++QG C+++ DL+ S+K + Y N V+ D LF V +Y F T+S P + DY +F L+ +T+ + ++IY N+++FL QPE P N LF R+VR+C D + S++ + + C + N+ Y + + + A + + D +LF F Y + C + I +I C G G++ N D C ++D F G + N+ + G + GH + + + + S+ + +Y F +A +G G L K + E L N+I +M + + S IY +++ ++ R + +C + C +CL P CGWC+ + C +D+C A P++ T+ C V P + P+V V T + LS + C F N E+ ++ + + CI P K++P I ++++ V+L+L L+ YNC+ + C CV + F C WC N C C N DCP L S E L G I L +N + + + C+ TA+ S+S + + + + ++ + + V W GN + I+ I+ ++ C + C C+ + ++CG+C+++ +C + C + S+W++ S KC P I E+ P + + ++G NLG +D+ N + + C E YI ++Q C++ D PV + K + + S+ + F P V + P+ GP GGT + + G L GS V F T C E I C + S S+Q+++ + Q D+ FE+ +P V++I +++G +TG NL+ + +P + + S+ +N + + C +P+
Sbjct: 59 HKTTGALYIGAVNRVYKLSGNLTL--LVSHDTGPEDDNKACYPPLIVQP--CSEPLISTNNINKLL------LIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGKDGTLFIGTAVDGKQDY----FPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYIYGFASG----NFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGC-VRNRVEYRLLQAAYLGKPGRVFA---------ASLNISAQDD---VLFAVFS--KGQKQYHHPPDDSALCVFSIRDINARIKERMQSCYQGEGNLELN--WLLGKDVPCTKAPVPIDDSFC--------GLDINQPLGGSQL----VTGHTLYTESRDRMTSVTSY-VYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKDGNSILRDMAFSLDNSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRCERANE-PYRFAATLNQCVKATVYPD----SIAVSEPSVPLLVKVTDVPDLSAG---ITCSF--GNLTEVEG-----RVNGNQILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWCKYRNLCTHDP-SSCSFQEGRVNASEDCPQLVRSEEIL-IPAGEVKPITLKARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMRISELPVDFSVVWN-GNFI---IDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRWLHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQ----CTPQENGYIIAEQIVCEMDAAPVDSKAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVTIMGENLGAGSSVTVLFGNQT----CEFYERTMTEIVC-------------YSAPSLTGVGSVQISVSVDRAQVRDILAFEYIDDPTVQRIEPEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLNTTTMSCFAPS 1109 HSP 2 Score: 105.531 bits (262), Expect = 6.341e-22 Identity = 122/486 (25.10%), Postives = 226/486 (46.50%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENT---VEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ ++++V N VE + KL ++L +++F+L F LE + + + ++ S + L L T +LK L+ + DK + N + + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS K ++ + +A + L++ T L TL Y + D + + K S +P + + S + + ++ + T ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS ++++
Sbjct: 1340 HPVL--RELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLILNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRP--------KAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTSISRYDSTFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHR 1796
BLAST of plexin A vs. Ensembl Zebrafish
Match: plxna2 (plexin A2 [Source:ZFIN;Acc:ZDB-GENE-090311-6]) HSP 1 Score: 205.682 bits (522), Expect = 1.776e-52 Identity = 251/1141 (22.00%), Postives = 450/1141 (39.44%), Query Frame = 2
Query: 188 NKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAY-SIVTNDRKFHSTVL---YHDQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHE------PKNGLFQV-RLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENL-----FNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNF--VDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN-DRIETPVAFQF-KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDV-QFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
+K+ ++ + N + + S N L TGP + + C P Q C + LIS + L L ++ + L+ C ++QG C+++ DL+ S+K + Y S V + ++ D LF V +Y F T+S P + DY +F L+ +T+ + ++IY N+++FL QPE P N LF R+VR+C D + S++ + + C + N+ Y + + + A + + D +LF F Y + C + I +I C G G++ N D C ++D F G + N+ + G + GH + + + + S+ + +Y F +A +G G L K + E L N+I +M + + S IY +++ ++ R + +C + C +CL P CGWC+ + C +D+C A P++ T+ C V P + P+V V T + LS + C F N E+ ++ + + CI P K++P I ++++ V+L+L L+ YNC+ + C CV + F C WC N C C N DCP L S E L G I L +N + + + C+ TA+ S+S + + + + ++ + + V W GN + I+ I+ ++ C + C C+ + ++CG+C+++ +C + C + S+W++ S KC P I E+ P + + ++G NLG +D+ N + + C E YI ++Q C++ D PV + K + + S+ + F P V + P+ GP GGT + + G L GS V F T C E I C + S S+Q+++ + Q D+ FE+ +P V++I +++G +TG NL+ + +P + + S+ +N + + C +P+
Sbjct: 7 HKTTGALYIGAVNRVYKLSGNLTL--LVSHDTGPEDDNKACYPPLIVQP--CSEPLISTNNINKLL------LIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGKDGTLFIGTAVDGKQDY----FPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYIYGFASG----NFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGC-VRNRVEYRLLQAAYLGKPGRVFA---------ASLNISAQDD---VLFAVFS--KGQKQYHHPPDDSALCVFSIRDINARIKERMQSCYQGEGNLELN--WLLGKDVPCTKAPVPIDDSFC--------GLDINQPLGGSQL----VTGHTLYTESRDRMTSVTSY-VYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKDGNSILRDMAFSLDNSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRCERANE-PYRFAATLNQCVKATVYPD----SIAVSEPSVPLLVKVTDVPDLSAG---ITCSF--GNLTEVEG-----RVNGNQILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWCKYRNLCTHDP-SSCSFQEGRVNASEDCPQLVRSEEIL-IPAGEVKPITLKARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMRISELPVDFSVVWN-GNFI---IDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRWLHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQ----CTPQENGYIIAEQIVCEMDAAPVDSKAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVTIMGENLGAGSSVTVLFGNQT----CEFYERTMTEIVC-------------YSAPSLTGVGSVQISVSVDRAQVRDILAFEYIDDPTVQRIEPEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLNTTTMSCFAPS 1057 HSP 2 Score: 105.145 bits (261), Expect = 8.090e-22 Identity = 122/486 (25.10%), Postives = 226/486 (46.50%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENT---VEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ ++++V N VE + KL ++L +++F+L F LE + + + ++ S + L L T +LK L+ + DK + N + + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS K ++ + +A + L++ T L TL Y + D + + K S +P + + S + + ++ + T ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS ++++
Sbjct: 1288 HPVL--RELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLILNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRP--------KAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTSISRYDSTFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHR 1744
BLAST of plexin A vs. Ensembl Zebrafish
Match: plxnb2b (plexin b2b [Source:ZFIN;Acc:ZDB-GENE-080902-1]) HSP 1 Score: 201.06 bits (510), Expect = 5.143e-51 Identity = 236/1087 (21.71%), Postives = 444/1087 (40.85%), Query Frame = 2
Query: 269 AIRKTGPVNHSVMCTEP-NQCQTSLCPKELISRDQCRIKLTDVFVKLWTF--ADSYLVVCYDVFQGFCEIIDLYN-----QFSSSYKNKAYSIVTNDRKFHSTVLYHDQRLFFANEVYH----PSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVN-----ENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFE-----DTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTA------MWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDS-HLVEGIYHIYNCAHS------RTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNY----FNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDF---EVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSV 3400
A +TGP + CT P + CQ +K T+ KL A+ L+VC +++G C +++L N +S S + Y+ T D + +V+ L N+ + Y +D + ++S T +Y F ++ T+ + FV + ++D R N+++FL ++ + + KN F + R+C D+ Y S+ ++ ++C ++N+ Y +V + +++ ++A + + +K E D K++ V + E C YP+ I + + C +G ++ E+PY S D C++ + +CG + E ++ + V R + + + ++ T+A +G N G + K L + + T N N+ ++ ++ +Y + KI++ ++ C+ +C+ C+ + P+CGWC+ G+C + +C+ A +W P Q+ + +I H KS V V P +L ++D+ ++C F S N+ + + +SC P IPP N++FV + +++ +N S + Y YNCA + C CV++ + C W V ++C S + N Q CP E + L VG+ I N Y F T+ + E D +T G + + + +F V + + + TG + ++ + +++C E C C + Y+C +C CV + +C + +S +CP P I +I P L + +KG NLG ++D+KN N C+++ + Y S C+I + R V + K + +F + P S+ PN GP GGT++ + G LN S+ ++ G P C + E+ + I+C+L+++ V + K P+ + +I A F+F NP V GG+ + G + + K S+
Sbjct: 63 ARAETGPKKDAKGCTPPVSTCQD--------------LKDTNNTNKLLLVHSANGSLIVCGSLYRGICSLLNLTNVKEQIYYSDSKGERTYAASTED---YVSVVGVMATLEIDNKPFSVFLVGKGYGSMD--SSKLIS----TRIVQNYRDWVVFESIIE--ASTVQAVPFVPKY-LHDFRFAFKNDNFVYFLFSRTLGRTDNKNFTF---ISRLCENDNHYYSYTELQLSCGLNNR--YNKVQAAYLSDPGKELAQVMTDSGEYGTVK-EWD-----------KVLFVVASSEEGATESALCMYPLKNINQKLLAIVTACYTDNGKIDDRLVVESPYT-SSKDGPCVKHDKDIVNRYKCGADFLPSPLASRQ--EFALKANPVFIRQNL--LTAVAVAVENDHTIAFLGHNAGEVIKVHLSSSPEPYNPGPGYKTSGYVNK---NLFFDKTQAHLYITTEKKIVKVPVQACHLKQDCQSCVAQKDPYCGWCVLEGRCSRRSECSRAEEKHGWLWSPNQQ--------CVKIISFHPPNLSCLKSQQVEINVRSLP--VLRDSDR-IRCSFGSYNSTA--------RMVDGRISCHLPEQPFIPPTPPNQDFVAVPVQIYVNVSVKVASSEYKFYNCAAAIQKAQNTPCTSCVSSSWGCQWNVAAHTCTDLSDAETGTNIIKQRQNKSCPRFENPDPVL-IPVGYKTRISFEGINLDPYKGRDFTIGTELMRGEE-DVNTESGPFYSFSGYMFSFDKAH---------ETSVLFHVRDKHTGK-KIDSSLNVTLYNCSLGREDCSLCKNADPKYQCVWCRQTSACVYEQLCASRESV-------ECPDPQITDITPRFGPLKGGIAVTIKGSNLGIQKDDIKNITVAGVN-----CRHLRERYSVSTSVICEIGPASLRKSGVVEIEVGRGRKGVSSKTVQFTYRDPVPLSVFPNRGPKAGGTVLTITGQDLNTASKEDLLILVGDVP--CRV-ESFGDQITCKLSNYLGDTVPSAHLDVKVQYGPQ---IPTSIKA--------AFQFSNNPSVSDHQPRSSFICGGRRVVVHGSGFDLVQKASI 1041 HSP 2 Score: 108.227 bits (269), Expect = 8.818e-23 Identity = 134/519 (25.82%), Postives = 229/519 (44.12%), Query Frame = 2
Query: 4337 KLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIF-----DYESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLEC-LKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGTGSFNYNEY------YGSSRIDGINISLAIVILYQ 5815
+ S L + F++ F LE + ++ K S L++ L L YT I++ L+ + ++ + + R+S+ ++ ++LSNW I +Y +L++ AG L L+ I + I GPV+ + K++Y LN+ LL +E+ L L+V + D V VL+CD ISQ K KI E++YK PYS +S L + + L + KE + TL Y+++D + ++ + + + SH E N+ L + K + R +D L E K+K + KD K IY L S ++G ++ DD F +VP V F + D+ + K+NSL LRFW+ ++ N F+FDV + T V++ L +++ MD C++ ++K L++ L++ I Y V YY+GI+ S + E D +N +A+ LY+
Sbjct: 1327 QFSNLLNSKTFLINFIRTLEGRPDFNARAKVYFASLLTVALHGKLEYYTDIMRTLLLGLMEDYVHSKNPKLLLRRSETVVERMLSNWMSICLYQYLKD-TAGEPLYKLFRAIKHQIEKGPVDVQVKKAKYTLNDTGLLGDDVEYSILTLQVLVQGEGPDI-TPVNVLNCDTISQVKEKILEQVYKNLPYSQRPKVDSVTL-EWRPGSTGQILSDLDVTSQKEGRWRRINTLAHYNVRDNATVILSSVQHTQQSYDQNHDSHEERNA--------------------LLEDDKVFHLVRPADELDE-----------IKSKRGSIKDKSMTKAITEIYLTRLLS-VKGTLQQFVDDFFHSVLCSGAAVPPAVKYFFDFLDEQALRHENVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHV---TEVVDASLSVIAQTFMDACTKTEHK---LSRDSPSNKLLYAKEISTYKRNVDEYYKGIRQMVSVSDQEMNTHLAEVSREHTDKLNTQVALHQLYR 1804
BLAST of plexin A vs. Ensembl Xenopus
Match: plxna1 (plexin A1 [Source:NCBI gene;Acc:100037845]) HSP 1 Score: 243.432 bits (620), Expect = 7.727e-64 Identity = 323/1436 (22.49%), Postives = 600/1436 (41.78%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPK--KASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYE-NCFV-NNSDIDCISPTTSNITQF------QKCSLLFAMEK--GSVCVYNTSITIFSTPV---LRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
N I ++V++ ++ IYA+ + ++ R + +C C+ CL P CGWC+ + C KD+C A L + + C + V P + + VS+ P+ + + N + C F E I + + C P K++ PI F+ L LK + YNC+ ++C CVN F C WC + C ++ C N DCP + S + + VG I L KN + + ++ C+ S TA+ S S + T + + + ++ V W G + P I+ ++ C L E C C+ + ++CG+C + KC + C ++ W+++ +C P I ++ P +++ + G NLG D++ + + H F Y+ S + S Q + N N F F F P + P+ GP GGT I + GS+LN GS +V + G P + + +E IR K P KA +Q++I+ ++ ++V + + +P V+KI +++GG +TG NL + +P + R + + E NC V N++ + C++P+ N + + + F M+ + V TS + PV L + N P++ L I + L+ + + ++ + +G C ++ + C + L G++ +TV+G ++ G + + + S++ + I+ + +L+++II+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ V +N + SN+++ + L + L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 452 NAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDACLGSRDPHCGWCVLHNMCSRKDKCERADEL-HRFTSDQRQCVQLTVHPRN-----------ISVTVSEVPMVLQAWNVPDLSAGVNCSFEDFTEMEGR-------ILDGKIYCTSPSTKDVIPITRGHGFLKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNA-ADCSFQEGRVNMSEDCPQILPSTQ-IYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQCQNTSYNYEGNDISDLPVNLSVVW------NGHFVIDNPQNIQAHLYKCSALRESCGLCLKSDRRFECGWCVSEKKCTLRQNCPAYENPWMHASTVNSRCTDPKITKLFPETGPKQGGTLLTITGENLGLRFEDIRFGVRV--GHVMFCVSYLATSLLCSTQSE---HNHN-------RFYGVF-------------FQVPSFNRVTPSRGPLSGGTWISIEGSYLNSGS--DVSVDIGGRPCMFSWRTAKE----------------IRCKTPQGPSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSIASGGTPLIVTGLNLATIKEPKI--RAKYGDAERENNCTVYNDTTMVCLAPSVENPLRSPPENGDRPDEIGFIMDNVLALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPLIIKGRNLIP---------AAPGNFRLNYTVLIGDTPCA-LTVSETQLLC--------------ESPNLTGQHKVTVTGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHK 1729
BLAST of plexin A vs. Ensembl Xenopus
Match: plxna1 (plexin A1 [Source:NCBI gene;Acc:100037845]) HSP 1 Score: 241.121 bits (614), Expect = 3.638e-63 Identity = 321/1428 (22.48%), Postives = 590/1428 (41.32%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS-TAIGSLS-ASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPK--KASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYE-NCFV-NNSDIDCISPTTSNITQF------QKCSLLFAMEK--GSVCVYNTSITIFSTPV---LRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
N I ++V++ ++ IYA+ + ++ R + +C C+ CL P CGWC+ + C KD+C A L + + C + V P N S T++ Q P N F FT R I + + C P K++ PI F+ L LK + YNC+ ++C CVN F C WC + C ++ C N DCP + S + + VG I L KN + + ++ C+ S T + +L S + C Q S++ ++ W +LT ++ C L E C C+ + ++CG+C + KC + C ++ W+++ +C P I ++ P +++ + G NLG D++ + + H F Y+ S + K+ +C F F F P + P+ GP GGT I + GS+LN GS +V + G IR K P KA +Q++I+ ++ ++V + + +P V+KI +++GG +TG NL + +P + R + + E NC V N++ + C++P+ N + + + F M+ + V TS + PV L + N P++ L I + L+ + + ++ + +G C ++ + C + L G++ +TV+G ++ G + + + S++ + I+ + +L+++II+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ V +N + SN+++ + L + L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 464 NAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDACLGSRDPHCGWCVLHNMCSRKDKCERADEL-HRFTSDQRQCVQLTVHPR-------NISVTMVLQAWNVPDLSAGVNCSFED--FTEMEGR----------ILDGKIYCTSPSTKDVIPITRGHGFLKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNA-ADCSFQEGRVNMSEDCPQILPSTQ-IYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQC--------QNTSVRFAL---WAFHYILT-----------HLYKCSALRESCGLCLKSDRRFECGWCVSEKKCTLRQNCPAYENPWMHASTVNSRCTDPKITKLFPETGPKQGGTLLTITGENLGLRFEDIRFGVRV--GHVMFCVSYLATSLLCCKK-QCNFYKATQSEHNHNRFYGVF-------------FQVPSFNRVTPSRGPLSGGTWISIEGSYLNSGS--DVSVDIGGQ---------------------------IRCKTPQGPSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSIASGGTPLIVTGLNLATIKEPKI--RAKYGDAERENNCTVYNDTTMVCLAPSVENPLRSPPENGDRPDEIGFIMDNVLALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPLIIKGRNLIP---------AAPGNFRLNYTVLIGDTPCA-LTVSETQLLC--------------ESPNLTGQHKVTVTGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHK 1714
BLAST of plexin A vs. Ensembl Xenopus
Match: plxna1 (plexin A1 [Source:NCBI gene;Acc:100037845]) HSP 1 Score: 233.032 bits (593), Expect = 1.118e-60 Identity = 319/1432 (22.28%), Postives = 594/1432 (41.48%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPK--KASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYE-NCFV-NNSDIDCISPTTSNITQF------QKCSLLFAMEK--GSVCVYNTSITIFSTPV---LRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
N I ++V++ ++ IYA+ + ++ R + +C C+ CL P CGWC+ + C KD+C A L + + C + V P + + S ++ Q P N F FT R I + + C P K+ P+ + F+ L LK + YNC+ ++C CVN F C WC + C ++ C N DCP + S + + VG I L KN + + ++ C+ S TA+ S S + T + + + ++ V W G + P I+ ++ C L E C C+ + ++CG+C + KC + C ++ W+++ +C P I ++ +++ + G NLG D++ + + H F Y+ S + + I K F F P + P+ GP GGT I + GS+LN GS +V + G P + + +E IR K P KA +Q++I+ ++ ++V + + +P V+KI +++GG +TG NL + +P + R + + E NC V N++ + C++P+ N + + + F M+ + V TS + PV L + N P++ L I + L+ + + ++ + +G C ++ + C + L G++ +TV+G ++ G + + + S++ + I+ + +L+++II+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ V +N + SN+++ + L + L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 465 NAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDACLGSRDPHCGWCVLHNMCSRKDKCERADEL-HRFTSDQRQCVQLTVHPRNISVTVSE----MVLQAWNVPDLSAGVNCSFED--FTEMEGR----------ILDGKIYCTSPSTKD--PLGRDWGFLKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNA-ADCSFQEGRVNMSEDCPQILPSTQ-IYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQCQNTSYNYEGNDISDLPVNLSVVW------NGHFVIDNPQNIQAHLYKCSALRESCGLCLKSDRRFECGWCVSEKKCTLRQNCPAYENPWMHASTVNSRCTDPKITKV--KTGPKQGGTLLTITGENLGLRFEDIRFGVRV--GHVMFCVSYLATSLLCCVPHRWAIS------------------------PKSFTFVVPSFNRVTPSRGPLSGGTWISIEGSYLNSGS--DVSVDIGGRPCMFSWRTAKE----------------IRCKTPQGPSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSIASGGTPLIVTGLNLATIKEPKI--RAKYGDAERENNCTVYNDTTMVCLAPSVENPLRSPPENGDRPDEIGFIMDNVLALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPLIIKGRNLIP---------AAPGNFRLNYTVLIGDTPCA-LTVSETQLLC--------------ESPNLTGQHKVTVTGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHK 1735
BLAST of plexin A vs. Ensembl Xenopus
Match: plxna1 (plexin A1 [Source:NCBI gene;Acc:100037845]) HSP 1 Score: 229.95 bits (585), Expect = 9.134e-60 Identity = 316/1436 (22.01%), Postives = 596/1436 (41.50%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPK--KASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYE-NCFV-NNSDIDCISPTTSNITQF------QKCSLLFAMEK--GSVCVYNTSITIFSTPV---LRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
N I ++V++ ++ IYA+ + ++ R + +C C+ CL P CGWC+ + C KD+C A L + + C + V P + + VS+ P+ + + N + C F E I + + C P K++ PI + L +++ + YNC+ ++C CVN F C WC + C ++ C N DCP + S + + VG I L KN + + ++ C+ S TA+ S S + T + + + ++ V W G + P I+ ++ C L E C C+ + ++CG+C + KC + C ++ W+++ +C P I ++ +++ + G NLG D++ + + H F Y+ S + + I K F F P + P+ GP GGT I + GS+LN GS +V + G P + + +E IR K P KA +Q++I+ ++ ++V + + +P V+KI +++GG +TG NL + +P + R + + E NC V N++ + C++P+ N + + + F M+ + V TS + PV L + N P++ L I + L+ + + ++ + +G C ++ + C + L G++ +TV+G ++ G + + + S++ + I+ + +L+++II+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+VL+CD I+Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ V +N + SN+++ + L + L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 465 NAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDACLGSRDPHCGWCVLHNMCSRKDKCERADEL-HRFTSDQRQCVQLTVHPRN-----------ISVTVSEVPMVLQAWNVPDLSAGVNCSFEDFTEMEGR-------ILDGKIYCTSPSTKDVIPITRGHGNIMPFLYCIVD--------FVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNA-ADCSFQEGRVNMSEDCPQILPSTQ-IYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQCQNTSYNYEGNDISDLPVNLSVVW------NGHFVIDNPQNIQAHLYKCSALRESCGLCLKSDRRFECGWCVSEKKCTLRQNCPAYENPWMHASTVNSRCTDPKITKV--KTGPKQGGTLLTITGENLGLRFEDIRFGVRV--GHVMFCVSYLATSLLCCVPHRWAIS------------------------PKSFTFVVPSFNRVTPSRGPLSGGTWISIEGSYLNSGS--DVSVDIGGRPCMFSWRTAKE----------------IRCKTPQGPSTGKAEIQIHINRATLYNSEVHYNYTEDPTVQKIEPEWSIASGGTPLIVTGLNLATIKEPKI--RAKYGDAERENNCTVYNDTTMVCLAPSVENPLRSPPENGDRPDEIGFIMDNVLALLIVNTTSFLYYPDPVFEPLTASGNLELKPSSPLIIKGRNLIP---------AAPGNFRLNYTVLIGDTPCA-LTVSETQLLC--------------ESPNLTGQHKVTVTGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHK 1731
BLAST of plexin A vs. Ensembl Xenopus
Match: plxna2 (plexin A2 [Source:NCBI gene;Acc:100144723]) HSP 1 Score: 223.402 bits (568), Expect = 9.985e-58 Identity = 251/1157 (21.69%), Postives = 466/1157 (40.28%), Query Frame = 2
Query: 122 CALTSEIFVYKYENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAYSIVTNDRKFHSTVLYH----DQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKH----EPKNGLFQV-RLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVS--KEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQE-NYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQF-TDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
CA S F ++ + L +++ ++ V N I + S N L TGP + C P Q P+ L + + ++ + D +A++ L+ C ++QG C+++ DL+ S+K + Y N+ V+ H D +LF V +Y F T+S P + DY ++F L+ +T+ + F++Y NY++FL QPE N LF R+VR+C D + S++ + + C N Y + + + +A R +I T+ D +LF F Y + C +PI I L C G G + N D +C + NF I G ++++ + + + +Y +++ +G G + K +E N L +++F+ +NK +Y +++ ++ R + +C ++CE+CL P CGWC+ + C KD+C A PF+ +K C ++V P+ L S S + +VS P + + C F + +E V++ + C+ P K+IP + +++ ++L+++ ++ V + YNC+ + C CVN F C WC N C C N DCP L S E L VG I L +N + + + C+ A+ S+S + + + + + + + V W GN +I+ I+ ++ C L E C C+ Y+CG+C + +C H C + ++W++ S+ KC P I EI+ + + + ++G NLG +++ + + C +E+ YI ++Q C++ + + + K +++ +++ F SP V + P+ GP GGT+I + G L GS I+ L NQ Y LN+ ++ S + +++ + Q +++QFE+ +P V +I +++G + G NL+ + +P + + S+ VN + + C++P
Sbjct: 37 CASLSNTFNTEHRDWTFSHLTVHQTTGAVYVGAVNRIYKLSGNLTL--LVSHNTGPGEDNKSCYPPQNVQPCSEPRTL-TNNVNKLLIID-------YAENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNETGTMYGVIVHTEGQDGKLFIGTAVDGKQDY----FPTLSSRKLPRDPESSTMLDYELYSDFVSSLIKIPSDTLALVSHFDIFYVYGFSSG----NYVYFLTVQPETPEGISSNSANDLFYTSRIVRLCKNDPKFHSYVSLPIGC-TKNGVEYRLLQAAYLTKPGATLA-------RSLKITTQDD-----VLFAIFS--KGQKQYHHPPDDSTLCVFPIKTINSLIKERLQSCYQGEGHLELN--WLLGKDVQCTKAPVPID-------DNFCGLDINQPLGGSTMVEGVTLYTESRDRMTSLASYVYNNYSVVFVGTKSGRIKKIRADGPPDGGIPYEVVNVTRDEIPLLRDMAFS---TDNK-YLYVMSERQVSRVEVEHCEQYSSCEECLSSGDPHCGWCVLHNTCSRKDKCERAHE-PFRFADNMKQCVKVDVQPNS--LPVSEHSLLLTLKVSNVP-----DLSAGVTCAF-GDLKQEEGQVQS-----GSRIDCVSPAAKDIPTMLAAQDWFGVELQLISKETGKTFVSTNFKFYNCSAHQHCLSCVNGDFRCHWCKYRNLCTHDPT-SCSFQEGRVNVSEDCPQLVPSEEIL-IPVGEVRPITLKARNLPQPQSGQRGYECVLNIQGVVHRMPALRFNSSSVQCQNSSYIYEGMDVSDLPVDFSVVWN-GNF---TIDNPQLIKVHLYKCAALRESCGLCLKADHKYECGWCNGEGRCTLHHHCMSPQNQWLDWSSRNVKCINPRIHEILTVSGPPEGGTRVTIRGANLGLNFSEIAQNVVVAGVQ----CTPVEEEYIIAEQIVCEMGQASPTSSSGPVLLCIEECKPEFMARSLQQYTFVSPTVAHLSPSRGPESGGTMITITGHNLAAGS------------IVSVTLGNQTCEYYGRSLNE------IVCVTAPSTHGLGPVHVSVSVDRAQLESNLQFEYIDDPKVLRIEPEWSIASGHTSLTVIGTNLDIIQQPRIRVKSNGKESVNVCKVVNATCLTCLAPA 1105 HSP 2 Score: 112.079 bits (279), Expect = 7.936e-24 Identity = 150/587 (25.55%), Postives = 266/587 (45.32%), Query Frame = 2
Query: 4277 HPLIVNKQIQV-IENTVEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMF--RQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIKGTGSF---NYNEYYG-SSRIDG--INISLAIVILYQNYINSVHKELVEVIQISNYPKDKQNEWITILEEVKNLYVAESF 5944
HP++ ++Q + +VE + KL ++L +++F+L F LE + + + ++ S + L L T +LK L+ + +K N+ + R + K+L+NWF L++ L+ AG L +L+ I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS L + Q + I K E L TL Y + D + + K S +PAS + S + + ++ + T ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD + L++ I Y V YY I + + N Y SR+ NI A+ +Y +Y++ EL+ ++ +D+Q + +V+ L A SF
Sbjct: 1336 HPVLQELEVQGNRQQSVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTALQGKLEYATDVLKQLLSDLIEKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLHCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDL-EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSTFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHGIYDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKNWVERYYADIAKLPAISDQDMNAYLAEQSRMHAAEFNIMSALNEIY-SYVSKYSVELITALE-----QDEQGRRHRLAYKVEQLIGAMSF 1896
BLAST of plexin A vs. Ensembl Mouse
Match: Plxna2 (plexin A2 [Source:MGI Symbol;Acc:MGI:107684]) HSP 1 Score: 254.218 bits (648), Expect = 3.132e-67 Identity = 364/1695 (21.47%), Postives = 696/1695 (41.06%), Query Frame = 2
Query: 854 LFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEI-MELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST----AIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQN-INDRIETPVAF-----QFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCIS--------PTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPN-KISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIA-ELNQA--AIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFE----DELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMF--RQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
+ R+VR+C D + S++ + C Y + + +A + +A + I ++ D +LF F Y + CA+PI I +++ + +++ C G G++ N D +C + NF I G ++ + + + + +Y +++ +G G L K +E + + +++F++ N+ +Y +++ ++ R + +C T C +CL P CGWC + C +D+C A W + ++ C + V P+ + S+ S + V+ P LSE + C F + + V+ + + CI P K++P I ++++ L+L++ ++ V + YNC+ + C CVN+ F C WC N C C N DCP L V E + VG I L +N + + + C+ + + A+ S+S + + + +++ V W GN + I+ ++ ++ C E C C+ ++CG+C+ + +C C + S W++ S KC P I EI+ + + + + G NLG +++ + + + C I YI ++Q C++ + + PV + +F TK +++ F +P V S+ P GP GGT++ + G +L GS V T C N I C + S+ + +++D + + +QFE+ +P V++I +++G ITG NL+ + +P V + S+ VN + + C++ P + + + LF + S+ +YN + I+ NP ++ PT +L + + + N S + ++ + +G CT ++ + C E + HK + + G + F G +S+ + S++ + I+ + +L++++I+ + K R +EN T K ++ + L+ +A E +A +Q +I++ + + P Y Y + LFP HP++ ++++V N ++ K KLF +++F+L F LE + + + ++ S + L L T +LK L+ + DK N+ + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS L + Q + I K E L TL Y + D + + K S +PAS + S + + +S + T ++ +PM + PD+ + + L + H++ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD+ W+ + ++D+ KL
Sbjct: 275 FYTSRIVRLCKDDPKFHSYVSLPFGC-TRAGVEYRLLQAAYLAKPGEALAQAFN-------ISSDED-----VLFAIFS--KGQKQYHHPPDDSALCAFPIRAINLQIKERLQS-CYHGEGNLELN--WLLGKDVQCTKAPVPID-------DNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSI----NQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRA-WEANRFAASISQCMSLEVHPNS--ISVSDHSRLLSLVVNDAP--NLSEG---IACAFGN-----LTEVEGQ--VSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TCSFQEGRINVSEDCPQL-VPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWN-GNFI---IDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG----VPCTPIPGEYIIAEQIVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSH----QQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT----CEFYGRSMNEIVC-----------VSPPSSNGLGPVPVSVSVDRARVD-SSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRVRVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQ-SLLIYNDTKFIYYP-----NPTFELLSPTGILDQKPGSPIILKGK-NLCPPASGGAKLNYTVMIGETPCT-VTVSETQLLC---EPPNLTGQHKVMVHV----------GGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYK---RKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIE----------------------------DHPVL--RELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDL-EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMIT--PDLESGVKVWHLVKN-HDHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKL 1821
BLAST of plexin A vs. Ensembl Mouse
Match: Plxna1 (plexin A1 [Source:MGI Symbol;Acc:MGI:107685]) HSP 1 Score: 175.637 bits (444), Expect = 2.739e-43 Identity = 157/677 (23.19%), Postives = 286/677 (42.25%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTA-IGSLS-ASNRLVC-----TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD-SKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKD---KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSN 3490
N I ++V++ N+ +YA+ + ++ + + +C T+CE CL P CGWC+ + C +D C A P + + C + V P + V +S+ PL + + N + C F + E ++ IH HS P + + PI + ++ V L LK + YNC+ ++C CVN F C WC + C +++ C N DCP + S + VG I L +N + + + CL S A + +L S+ L C +++ V + + ++ V W GN + I+ I+ ++ C L + C C+ ++CG+C + +C +H C D + W+++ +C P I+++ P + + + G NLG DV+ + + + C +E YIS++Q C+I + + + + + L K F F +P Y + P+ GP GGT I + GS LN GS +V + G P C+ I C P A + +NI+ + +V++ + +P + +I +++GG + +TG NL + +P + + + +C V N++ + C +P+ N
Sbjct: 482 NPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERAEE-PQRFASDLLQCVQLTVQPRN-----------VSVTMSQVPLVLQAWNVPDLSAGVNCSF--EDFTETESILEDGRIHCHS-----PSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRHVCTNNA-ADCAFLEGRVNMSEDCPQILPSTH-IYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDV---SDLPVNLSVVWN-GNFV---IDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVG----KVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGS--DVAVSIGGRP--CSFSWRNSREIRCLTPP------------GHTPGSAPIVININRAQLSNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGG-IERENSCMVYNDTTMVCRAPSIDN 1109 HSP 2 Score: 102.834 bits (255), Expect = 3.809e-21 Identity = 124/487 (25.46%), Postives = 225/487 (46.20%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 1337 HPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1788
BLAST of plexin A vs. Ensembl Mouse
Match: Plxna1 (plexin A1 [Source:MGI Symbol;Acc:MGI:107685]) HSP 1 Score: 175.637 bits (444), Expect = 2.739e-43 Identity = 157/677 (23.19%), Postives = 286/677 (42.25%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTA-IGSLS-ASNRLVC-----TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD-SKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKD---KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSN 3490
N I ++V++ N+ +YA+ + ++ + + +C T+CE CL P CGWC+ + C +D C A P + + C + V P + V +S+ PL + + N + C F + E ++ IH HS P + + PI + ++ V L LK + YNC+ ++C CVN F C WC + C +++ C N DCP + S + VG I L +N + + + CL S A + +L S+ L C +++ V + + ++ V W GN + I+ I+ ++ C L + C C+ ++CG+C + +C +H C D + W+++ +C P I+++ P + + + G NLG DV+ + + + C +E YIS++Q C+I + + + + + L K F F +P Y + P+ GP GGT I + GS LN GS +V + G P C+ I C P A + +NI+ + +V++ + +P + +I +++GG + +TG NL + +P + + + +C V N++ + C +P+ N
Sbjct: 482 NPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERAEE-PQRFASDLLQCVQLTVQPRN-----------VSVTMSQVPLVLQAWNVPDLSAGVNCSF--EDFTETESILEDGRIHCHS-----PSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRHVCTNNA-ADCAFLEGRVNMSEDCPQILPSTH-IYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDV---SDLPVNLSVVWN-GNFV---IDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVG----KVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGS--DVAVSIGGRP--CSFSWRNSREIRCLTPP------------GHTPGSAPIVININRAQLSNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGG-IERENSCMVYNDTTMVCRAPSIDN 1109 HSP 2 Score: 102.834 bits (255), Expect = 3.809e-21 Identity = 124/487 (25.46%), Postives = 225/487 (46.20%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 1337 HPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1788
BLAST of plexin A vs. Ensembl Mouse
Match: Plxnb2 (plexin B2 [Source:MGI Symbol;Acc:MGI:2154239]) HSP 1 Score: 166.392 bits (420), Expect = 1.949e-40 Identity = 184/918 (20.04%), Postives = 365/918 (39.76%), Query Frame = 2
Query: 743 EFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVT-CAYPIAEIMELYDVVRNLCLVGSGSVNENP-YNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFED---TNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCT----TAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRT------CAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKA--SIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSK---EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLS 3427
+FV +F +D F Y+FF+ N ++KH KN + L R+C D Y S++++ + C + + + A+V+ A + L+ F + + R T C +P+ ++ E + RN C G+ Y + +C ++ CG ++ + +G G ++ V+ R G+ + + + T+A +G +DG + K L D Y ++ I ++ ++ N S +YA+ K+ R ++ C + C C P+CGWC+ G+C K +C+ T WL + R ++ A + + P + + ++S +PL L+E+D+ L C F ++ A V+ I N S ++ VD+ +++L+ L Y Y+C + + C C +N++ C W + C +S ++ + + +CP ++ + L + + KN S +V E + + ++ S+ +F+ K+ ++ + V N+ ++ ++ +++C C C+ Y+C +C +++CV + +C N S+ CP P I I P L ++ + G NLG +DVK N C + + Y S + C I+ E P + K S +F + P+ S+EP GP GGT + +NG+ L+ GS+ +V+ N + C + F + + + ++ + P + +L++ + + + F + NP ++ + +GG+ +TG + + K ++ E S
Sbjct: 217 QFVAAF------EDDF---YVFFVFNH-QDKHPAKN---RTLLARMCKDDPSYYSYVEMDLQCQDPSDPQDSAFGTCLAASVATSGAG--------------------RALYAVF-----SRDGRSTGGPGAGLCVFPLDKVREKIEANRNACYTGAREAGRTIFYKPFHGEIQCGGHLIGASESFPCGSEHL-PYPLGSRDG---LVATAVLHRGGLN-LTAVTVTAENDHTVAFLGTSDGRILKVYLAPDGTSAEYGSIPVDINKKIKQDLALSGNLSSLYAMTQDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEETGHWL-WSREKSCVA--ITDAFPQNMSRRAQGE-----VRLSVSPLPTLTEDDELL-CLF-GDSPPHPARVEDDTVICNSPSSIPS--------TPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLVENLPCISCASNRWTCQWDLQYYECREASPNP-EEGIIRAHMEDNCPQF-LAPDPLVIPMNHETEVTFQGKNLETVKVSSL-YVGSELLNFEETV-TMHESDTF--SFRTPKLSHDGNETLPLHLYVKSFGKNI-------DSKLQVTLYNCSFGRSDCSLCLAADPAYRCVWCRGQNRCVYEALCSNVTSE--------CPPPVITRIQPETGPLGGGILVTIHGSNLGVKADDVKKITVAGQN-----CAFEPRGYSVSTRIVCAIEAS----EMPFTGGIEVDVNGKLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGTTLTINGTHLDTGSKEDVRVTL--------------NDVPCEVTKFGAQLQCVTGQQLA-PGQVTLEIYYGGSRVPSPGISFTYCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVVIAEPLRS 1028 HSP 2 Score: 114.005 bits (284), Expect = 1.518e-24 Identity = 132/538 (24.54%), Postives = 247/538 (45.91%), Query Frame = 2
Query: 4337 KLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIAL---KEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT--SFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIK---GTGSFNYNEYYGS---SRIDGINISLAIVILYQNYINSVHKELVEVIQ 5860
+ S L + F++ F LE+ +E ++ K S L++ L L YT I++ L ++ + + + M R+S+ ++ ++LSNW I +Y +L++ +AG L L+ I + + GPV+ K++Y LN+ LL +E+ L + V + D+ + V+VL+CD ISQ K KI +++Y+ P S W +S L + + ++L+ + L +E + TL Y+++DG + ++ VS +S +D+P + L + ++ + R +D + E K+K + K+ K IY L S ++G ++ D+ F +VP V F + +D+ + K+NSL LRFW+ ++ N F+FDV + H V L +++ MD C+ ++K L++ L++ I Y V +YY+GI+ + N + + D +N +A+ LYQ Y + E++ ++
Sbjct: 1322 QFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKD-SAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDA-IPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKPDSVVL----EWRPGSTAQILSDLDLTSQREGRWKRINTLMHYNVRDGATLILS----------KVGVSQQPEDS-----------QQDLPGERHALLEEENRVWHLVRPTDEVDEG-----------KSKRGSMKEKERTKAITEIYLTRLLS-VKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHV--HEVVDASLSVIAQTFMDACTRTEHK---LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQ-YTQKYYDEIINALE 1814
BLAST of plexin A vs. Ensembl Mouse
Match: Plxnb2 (plexin B2 [Source:MGI Symbol;Acc:MGI:2154239]) HSP 1 Score: 166.392 bits (420), Expect = 1.949e-40 Identity = 184/918 (20.04%), Postives = 365/918 (39.76%), Query Frame = 2
Query: 743 EFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVT-CAYPIAEIMELYDVVRNLCLVGSGSVNENP-YNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFED---TNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCT----TAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRT------CAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKA--SIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSK---EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLS 3427
+FV +F +D F Y+FF+ N ++KH KN + L R+C D Y S++++ + C + + + A+V+ A + L+ F + + R T C +P+ ++ E + RN C G+ Y + +C ++ CG ++ + +G G ++ V+ R G+ + + + T+A +G +DG + K L D Y ++ I ++ ++ N S +YA+ K+ R ++ C + C C P+CGWC+ G+C K +C+ T WL + R ++ A + + P + + ++S +PL L+E+D+ L C F ++ A V+ I N S ++ VD+ +++L+ L Y Y+C + + C C +N++ C W + C +S ++ + + +CP ++ + L + + KN S +V E + + ++ S+ +F+ K+ ++ + V N+ ++ ++ +++C C C+ Y+C +C +++CV + +C N S+ CP P I I P L ++ + G NLG +DVK N C + + Y S + C I+ E P + K S +F + P+ S+EP GP GGT + +NG+ L+ GS+ +V+ N + C + F + + + ++ + P + +L++ + + + F + NP ++ + +GG+ +TG + + K ++ E S
Sbjct: 217 QFVAAF------EDDF---YVFFVFNH-QDKHPAKN---RTLLARMCKDDPSYYSYVEMDLQCQDPSDPQDSAFGTCLAASVATSGAG--------------------RALYAVF-----SRDGRSTGGPGAGLCVFPLDKVREKIEANRNACYTGAREAGRTIFYKPFHGEIQCGGHLIGASESFPCGSEHL-PYPLGSRDG---LVATAVLHRGGLN-LTAVTVTAENDHTVAFLGTSDGRILKVYLAPDGTSAEYGSIPVDINKKIKQDLALSGNLSSLYAMTQDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEETGHWL-WSREKSCVA--ITDAFPQNMSRRAQGE-----VRLSVSPLPTLTEDDELL-CLF-GDSPPHPARVEDDTVICNSPSSIPS--------TPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLVENLPCISCASNRWTCQWDLQYYECREASPNP-EEGIIRAHMEDNCPQF-LAPDPLVIPMNHETEVTFQGKNLETVKVSSL-YVGSELLNFEETV-TMHESDTF--SFRTPKLSHDGNETLPLHLYVKSFGKNI-------DSKLQVTLYNCSFGRSDCSLCLAADPAYRCVWCRGQNRCVYEALCSNVTSE--------CPPPVITRIQPETGPLGGGILVTIHGSNLGVKADDVKKITVAGQN-----CAFEPRGYSVSTRIVCAIEAS----EMPFTGGIEVDVNGKLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGTTLTINGTHLDTGSKEDVRVTL--------------NDVPCEVTKFGAQLQCVTGQQLA-PGQVTLEIYYGGSRVPSPGISFTYCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVVIAEPLRS 1028 HSP 2 Score: 114.005 bits (284), Expect = 1.518e-24 Identity = 132/538 (24.54%), Postives = 247/538 (45.91%), Query Frame = 2
Query: 4337 KLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIAL---KEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT--SFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIK---GTGSFNYNEYYGS---SRIDGINISLAIVILYQNYINSVHKELVEVIQ 5860
+ S L + F++ F LE+ +E ++ K S L++ L L YT I++ L ++ + + + M R+S+ ++ ++LSNW I +Y +L++ +AG L L+ I + + GPV+ K++Y LN+ LL +E+ L + V + D+ + V+VL+CD ISQ K KI +++Y+ P S W +S L + + ++L+ + L +E + TL Y+++DG + ++ VS +S +D+P + L + ++ + R +D + E K+K + K+ K IY L S ++G ++ D+ F +VP V F + +D+ + K+NSL LRFW+ ++ N F+FDV + H V L +++ MD C+ ++K L++ L++ I Y V +YY+GI+ + N + + D +N +A+ LYQ Y + E++ ++
Sbjct: 1322 QFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKD-SAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDA-IPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKPDSVVL----EWRPGSTAQILSDLDLTSQREGRWKRINTLMHYNVRDGATLILS----------KVGVSQQPEDS-----------QQDLPGERHALLEEENRVWHLVRPTDEVDEG-----------KSKRGSMKEKERTKAITEIYLTRLLS-VKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHV--HEVVDASLSVIAQTFMDACTRTEHK---LSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQ-YTQKYYDEIINALE 1814
BLAST of plexin A vs. UniProt/SwissProt
Match: sp|Q9UIW2|PLXA1_HUMAN (Plexin-A1 OS=Homo sapiens OX=9606 GN=PLXNA1 PE=1 SV=3) HSP 1 Score: 259.225 bits (661), Expect = 6.035e-68 Identity = 325/1437 (22.62%), Postives = 605/1437 (42.10%), Query Frame = 2
Query: 1541 NMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTA-IGSLS-ASNRLVC-----TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGND-DSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFK---TKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSNITQF------QKCSLLFAME--KGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTV-SGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHKNWN-----TAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
++V++ N +YA+ + ++ R + +C T+CE CL P CGWC+ + C +D C A P + + C + V P + V +S+ PL + + N + C F E + + + C P + + PI ++ V L LK + YNC+ ++C CVN F C WC + C + ++ C N DCP + S + + VG I L +N + + + CL S A + +L S+ L C +++ V + + ++ V W GN + I+ I+ ++ C L E C C+ ++CG+C + +C +H C D + W++++ +C P I+++ P + + + G NLG DV+ + + + C +E YIS++Q C+I + + + + + L K F F +P Y + P+ GP GGT I + GS LN GS +V + G P C+ I C +P A + +NI+ + +V++ + +P + +I +++GG + +TG NL + +P + + + C V N++ + C +P+ +N + + L F M+ + + + +TS + PVL +S PT LL + + + N + ++ + +G CT ++ + C + L G++ +TV +G +F G + + + S++ + I+ + +L++VI+ + K++ R + +++ + + + R E + A +Q +IH+ N P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ LDCD ++QAK K+ + YK PYS K ++ + +A I L++ T L TL Y + DG ++ + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 489 DLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADE-PQRFAADLLQCVQLTVQPRN-----------VSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESE-------SVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVC-THNVADCAFLEGRVNVSEDCPQILPSTQ-IYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDV---SDLPVNLSVVWN-GNFV---IDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVG----KVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGS--DVAVSVGGRP--CSFSWRNSREIRCLTPP------------GQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGG-IERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVL----EPLS-PTGLLELKPSSPLILKGR-NLLPPAPGNSRLNYTVLIGSTPCT-LTVSETQLLC--------------EAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRP--------KAADMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1790
BLAST of plexin A vs. UniProt/SwissProt
Match: sp|P70207|PLXA2_MOUSE (Plexin-A2 OS=Mus musculus OX=10090 GN=Plxna2 PE=1 SV=2) HSP 1 Score: 254.218 bits (648), Expect = 2.191e-66 Identity = 364/1695 (21.47%), Postives = 696/1695 (41.06%), Query Frame = 2
Query: 854 LFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEI-MELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST----AIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQN-INDRIETPVAF-----QFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCIS--------PTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPN-KISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIA-ELNQA--AIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFE----DELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMF--RQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
+ R+VR+C D + S++ + C Y + + +A + +A + I ++ D +LF F Y + CA+PI I +++ + +++ C G G++ N D +C + NF I G ++ + + + + +Y +++ +G G L K +E + + +++F++ N+ +Y +++ ++ R + +C T C +CL P CGWC + C +D+C A W + ++ C + V P+ + S+ S + V+ P LSE + C F + + V+ + + CI P K++P I ++++ L+L++ ++ V + YNC+ + C CVN+ F C WC N C C N DCP L V E + VG I L +N + + + C+ + + A+ S+S + + + +++ V W GN + I+ ++ ++ C E C C+ ++CG+C+ + +C C + S W++ S KC P I EI+ + + + + G NLG +++ + + + C I YI ++Q C++ + + PV + +F TK +++ F +P V S+ P GP GGT++ + G +L GS V T C N I C + S+ + +++D + + +QFE+ +P V++I +++G ITG NL+ + +P V + S+ VN + + C++ P + + + LF + S+ +YN + I+ NP ++ PT +L + + + N S + ++ + +G CT ++ + C E + HK + + G + F G +S+ + S++ + I+ + +L++++I+ + K R +EN T K ++ + L+ +A E +A +Q +I++ + + P Y Y + LFP HP++ ++++V N ++ K KLF +++F+L F LE + + + ++ S + L L T +LK L+ + DK N+ + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS L + Q + I K E L TL Y + D + + K S +PAS + S + + +S + T ++ +PM + PD+ + + L + H++ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD+ W+ + ++D+ KL
Sbjct: 275 FYTSRIVRLCKDDPKFHSYVSLPFGC-TRAGVEYRLLQAAYLAKPGEALAQAFN-------ISSDED-----VLFAIFS--KGQKQYHHPPDDSALCAFPIRAINLQIKERLQS-CYHGEGNLELN--WLLGKDVQCTKAPVPID-------DNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSI----NQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRA-WEANRFAASISQCMSLEVHPNS--ISVSDHSRLLSLVVNDAP--NLSEG---IACAFGN-----LTEVEGQ--VSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TCSFQEGRINVSEDCPQL-VPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWN-GNFI---IDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG----VPCTPIPGEYIIAEQIVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSH----QQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT----CEFYGRSMNEIVC-----------VSPPSSNGLGPVPVSVSVDRARVD-SSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRVRVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQ-SLLIYNDTKFIYYP-----NPTFELLSPTGILDQKPGSPIILKGK-NLCPPASGGAKLNYTVMIGETPCT-VTVSETQLLC---EPPNLTGQHKVMVHV----------GGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYK---RKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIE----------------------------DHPVL--RELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDL-EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMIT--PDLESGVKVWHLVKN-HDHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKL 1821
BLAST of plexin A vs. UniProt/SwissProt
Match: sp|O75051|PLXA2_HUMAN (Plexin-A2 OS=Homo sapiens OX=9606 GN=PLXNA2 PE=1 SV=4) HSP 1 Score: 199.134 bits (505), Expect = 1.540e-49 Identity = 220/1063 (20.70%), Postives = 429/1063 (40.36%), Query Frame = 2
Query: 413 FADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAY-SIVTNDRKFHSTVLY---HDQRLFFANEVYHPSNYREIDFNTMSILSFPN--MTYFKPDYPFQANF-GKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKH-----EPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEI-MELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQN-INDRIETPVAF-----QFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPT 3481
++++ L+ C ++QG C+++ DL+ S+K + Y S V + ++ D +LF V +Y F T+S P + DY ++F L+ +T+ + F+IY F ++FL QPE + + R+VR+C D + S++ + C Y + + +A D +A + I ++ D +LF F Y + CA+PI I +++ + +++ C G G++ N D +C + NF I G ++ + + + + +Y +++ +G G L K +E + L + +++F++ ++ +Y +++ ++ R + +C T C +CL P CGWC + C +D+C A W P + ++ C + V PS + S S + VS P + + C F + + V+ + + CI P K++P I ++++ L+L++ ++ V + YNC+ + C CVN+ F C WC N C C N DCP L V E + VG I L +N + + + C+ + A+ S+S + + + +++ V W GN + I+ ++ ++ C E C C+ + ++CG+C+ + +C C + S W++ S KC P I EI+ + + + + G NLG +++ + + + C + YI ++Q C++ + + PV + +F TK +++ F +P V S+ P GP GGT++ + G +L GS V T C + I C + S+ + +++D + +++QFE+ +P V++I +++G ITG NL+ + +P + + S+ VN + + C++P+
Sbjct: 121 YSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDY----FPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGF----VYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGC-TRAGVEYRLLQAAYLAKPGDSLAQAFN-------ITSQDD-----VLFAIFS--KGQKQYHHPPDDSALCAFPIRAINLQIKERLQS-CYQGEGNLELN--WLLGKDVQCTKAPVPID-------DNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSI----DQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQA-WEPNRFAASISQCVSLAVHPSS--ISVSEHSRLLSLVVSDAP-----DLSAGIACAFGN-----LTEVEGQ--VSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TCSFQEGRINISEDCPQL-VPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWN-GNFI---IDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG----VPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSH----QQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQT----CEFYGRSMSEIVC-----------VSPPSSNGLGPVPVSVSVDRAHVD-SNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPS 1101 HSP 2 Score: 110.923 bits (276), Expect = 9.838e-23 Identity = 131/512 (25.59%), Postives = 231/512 (45.12%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENTVEYSRKLSKLFE----DELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMF--RQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
HP++ ++++V N ++ K KLF +++F+L F LE + + + ++ S + L L T +LK L+ + DK N+ + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS L + Q + I K E L TL Y + D + + K S +PAS + S + + +S + T ++ PM + PD+ + + L + H++ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD+ W+ + ++D+ KL
Sbjct: 1332 HPVL--RELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDL-EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HDHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKL 1821
BLAST of plexin A vs. UniProt/SwissProt
Match: sp|Q9V4A7|PLXB_DROME (Plexin-B OS=Drosophila melanogaster OX=7227 GN=PlexB PE=1 SV=2) HSP 1 Score: 180.259 bits (456), Expect = 8.985e-44 Identity = 259/1167 (22.19%), Postives = 452/1167 (38.73%), Query Frame = 2
Query: 197 HKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFA---DSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLYHDQR--------LFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCD-IDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKS---TDKRCMEDGFTSTGKGECGGKNFNKFIIGDHY-GENSIIGHRVIS-RNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDT--NYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRV-SPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSE------------NDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSH--LVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSA---SNRLVCTFQM--MKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEH-----CDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWINSKFQ-KCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITL-----ENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSI--------QFTDVQFEFFP-----------NPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSD-IDCISP 3478
H + N IL+ +EN LA TGP++ S QC CP+++ L + F K+ + D L+ C + QG CEI L +F ++ + A + ND + R L+ + +YR D +S ++ Y ++ Q + + + + F ++++ F+ + Y +F++ Q + H + RL RIC D +Y S+ +I + C +N Y V V S +A K + D H +L F +N E+ ++ C Y I +I +++ + N+ L +G+ + + S D RC G G +N +G G + I H + N + ++ +LA +G N G++ K L + Y + N I N +++ K +Y ++ KI + + +C TNC CL PFCGWC +C V+ C R A +++ +E+ + P K P+S LS N K+ +C F ++ + I + L C P P I N + + + L V ++++ V + ++C+H C C+ + + C+WC+ DN C+ SL +C+ + CP L+ + + V PI I L +N ++ F+C T A L A SN++V + + + + V+W + + +I T ++ C L H C CV YKC +C+ + CV C D S S + +CPLP I I P + + ++I ++G NLG E DV+ I + E ++Q K ++ S + I+ ND T + QF FK + + + P GP GGT + + G FLNIGS + I ++ + + +SC ++ + + + +L+ I SI F Q P +P + +I + +GG++ + G LN + KP + + +C V NS+ ++C SP
Sbjct: 96 HNVLFAGATNKILKLNEN--LRVLAEAVTGPLHDS------PQCHAGGCPEDI------ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSL-PRFPATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRH-DVPAISSRRLDDLNY--AEFSIQQSIINIDVKYRDH-FLVDYIYGFNSSE---------YAYFIIVQ-KKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQ-----------KMGIKKDDH-VLVTVFSPSREISNQPESKSAM--CIYSIKDIEDMF--IENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSL--------GNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTC----------QRDTSASRWLSLGSGQQCIEFESIIP------EKIPISELSHLHLIIRTLPEPFNAKY-RCVFGNSTPIDAE-------ILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSL-QCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLC--TIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVT-------LYKCDVLGSHREHPDCSLCVTRDPKYKCAWCS--NSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFK--------------NVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHI--DVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSP 1157 HSP 2 Score: 95.5153 bits (236), Expect = 4.518e-18 Identity = 210/937 (22.41%), Postives = 393/937 (41.94%), Query Frame = 2
Query: 2990 PRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFK----RSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSI---TIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRC-----NIIEVNQIDIYHKYQISLLM---GKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEAN--EVLKRGIAELNQAAIQDEIHKNWNTA-PIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKL---SKLFEDELFVLMFFSFLEDHQEVES--KKSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSD-LLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYS----------NWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGY-TLKTLKDYDIKDGDNICVAMK---NESLPASNTASVSHLES----NSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
PR+ I+P GG ++ V+G +LN + E++ Y + N+ + + N E + +K + +N +K +L++ +S Q T+ +++ N + +K + F GD FR T N FVNN ++D + + TQ L F M+ + V N + I ST V +P + P + +++ K + I E+ + A + D + +G C S N + C + ++ + + L++ G+N+ V GY++++ + + ++++ I + +++ + ++V++I +K +R E + I + I E+N K+ AEL Q + D +T P ++ YI+ FP HP++ + + + Y + +L ++ F+LMF LE + S + ++ S + ++LM + T ILK L+ DK ++ + M R+++ ++ K+L+N+ I MYD+L+ AG +L +L+ I + I G V+ T+ ++Y+L+E LL ++ + L + + D ++ V D D ISQ KLKI + I+K +P+S W L ++D + K V G+ L TL Y +K+ + + + N +P S + + + N++ + +I + + IP H ++ +NS ++ D + + T++L +K G I+ DD F E +P V LF + + D IV A KSN L LRFW+ I N DF+FDV K V CL +++ MD CS ++++
Sbjct: 1097 PRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERV------NKTSCVVINSNQMECPSPPVNYKFETFKKTN-RKMDTELHLQNSSFQ-TETRYK---NEYDRKKRRADF-----------GD----------TFRLYTNAGSSANYFVNN-NMDVTTFVKVHETQLN-LQLSFVMDNVQL-VRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNL----AADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAER---EYKRIQIQMITLESNVRSECKQAFAEL-QTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVS----------------------------DHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEY-AGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDL--DEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDED-----------LTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNI---KNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATK--GTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVN--KTYSVDSCLSVIAQTFMDACSTSEHR 1941
BLAST of plexin A vs. UniProt/SwissProt
Match: sp|P70206|PLXA1_MOUSE (Plexin-A1 OS=Mus musculus OX=10090 GN=Plxna1 PE=1 SV=1) HSP 1 Score: 175.637 bits (444), Expect = 1.916e-42 Identity = 157/677 (23.19%), Postives = 286/677 (42.25%), Query Frame = 2
Query: 1526 NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSEN----DKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTA-IGSLS-ASNRLVC-----TFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD-SKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKD---KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSN 3490
N I ++V++ N+ +YA+ + ++ + + +C T+CE CL P CGWC+ + C +D C A P + + C + V P + V +S+ PL + + N + C F + E ++ IH HS P + + PI + ++ V L LK + YNC+ ++C CVN F C WC + C +++ C N DCP + S + VG I L +N + + + CL S A + +L S+ L C +++ V + + ++ V W GN + I+ I+ ++ C L + C C+ ++CG+C + +C +H C D + W+++ +C P I+++ P + + + G NLG DV+ + + + C +E YIS++Q C+I + + + + + L K F F +P Y + P+ GP GGT I + GS LN GS +V + G P C+ I C P A + +NI+ + +V++ + +P + +I +++GG + +TG NL + +P + + + +C V N++ + C +P+ N
Sbjct: 482 NPILRDLVLSPNRQYLYAMTEKQVTQVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERAEE-PQRFASDLLQCVQLTVQPRN-----------VSVTMSQVPLVLQAWNVPDLSAGVNCSF--EDFTETESILEDGRIHCHS-----PSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRHVCTNNA-ADCAFLEGRVNMSEDCPQILPSTH-IYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDV---SDLPVNLSVVWN-GNFV---IDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVG----KVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGS--DVAVSIGGRP--CSFSWRNSREIRCLTPP------------GHTPGSAPIVININRAQLSNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGG-IERENSCMVYNDTTMVCRAPSIDN 1109 HSP 2 Score: 102.834 bits (255), Expect = 2.665e-20 Identity = 124/487 (25.46%), Postives = 225/487 (46.20%), Query Frame = 2
Query: 4277 HPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + +K + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK PYS K ++ + +A I L++ T L TL Y + DG ++ + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++ Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 1337 HPVL--KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHLDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1788
BLAST of plexin A vs. TrEMBL
Match: A0A0K0LJ46 (Plexin A (Fragment) OS=Schmidtea mediterranea OX=79327 GN=plxnA PE=2 SV=1) HSP 1 Score: 1893.63 bits (4904), Expect = 0.000e+0 Identity = 989/992 (99.70%), Postives = 990/992 (99.80%), Query Frame = 2
Query: 1733 PFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETS 4708
PFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLL+GKNVLTVSGYIQFEKGDISLDNMSVIII IMVVIIFIIILVVVIIVKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYNESKNINESIINLNYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDLLILYLNILNIINNGPVNWETS
Sbjct: 1 PFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLIGKNVLTVSGYIQFEKGDISLDNMSVIIITTIMVVIIFIIILVVVIIVKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYNESKNINESIINLNYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDLLILYLNILNIINNGPVNWETS 992
BLAST of plexin A vs. TrEMBL
Match: A0A016RRU9 (Sema domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0392.g578 PE=4 SV=1) HSP 1 Score: 306.99 bits (785), Expect = 3.535e-80 Identity = 458/1966 (23.30%), Postives = 780/1966 (39.67%), Query Frame = 2
Query: 206 ILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRI--KLTDVFVKLWTFAD--SYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLY-----HDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAE---------IMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFE-DTNYLFSTENLFNN---ISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGT-NCEDCL-RVSPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLI-NVIPSH---SILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLIND--SHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNFEI----------QNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEF-----------------------QVFDCLKLSEHCDDCVHLPQI-YKCGFCTVKDKCVQKHIC-GNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDR-IETPVAFQFKFKTKDKYLVSK-EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFE-----VKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPS-VAFRCETFLSIYENCFVNNSDID-CISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTP-VLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXX-----XXXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIE-NTVEYS-RKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXX-XXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCL---IKLNQDEVPE---SERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT---SFLPDISKRIPIHRLSDSLH-ENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYES----VPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGI 5722
+ V+G NY+ ++L + TGP++ S +QC+ D C T+ K D S L+ C +FQG C + +L+N S ++ ND + V + L+ +R+ D ++ L ++ K + G E +F S+ I D Y +F Q E + Q RLVR+C+ D + S+ ++ + C I + Y + VA ++A K+ S+ ++L+ F +T+ R T S V C YPI + IME Y ++ + P+ FKS+D + S ECG ++ NK I G I +++ + + ++ I + T+A IG +DG L K + + DT +++TE + N I ++ +EN Y + SK+++ NC G C CL + PFCGWC+ N C +D C T++ WL FQ NR CP I V+P + +Y N S L + + L+C F + + + + A H+ +L C P +P I N++ L ++ + + + Y+C +C+ C ++F C WC+ N C++ L KC+K + + CP + + L G +I + +N F T+F C +GS+ V TF +I C G L G P+EF +V+ C L+ +C C+ L Y+CG+C + ++CV+ C W+NS Q C P+I E P + ++ + + G NLG DV A+ + N H C I Y + + C+ + + P+ + + + VSK +F++ P V +++PN GP GGT + + G+ L+ GS EV ++G + C +L + + + CR+ + K +R +P + QL +EF NP V I K ++ GG + G+ L +P V + C V + + C+SP + + FA + + + ++ P V + + P + +TIN D ++V A + D KI VG + C + + C K + + V+ G I F G +S D+ S+ I ++++ I +LV ++ +K S QR +++ K + T K+ E E LNQ ++ P Y Y LFP N+P HP++ + ++ + +E R+ KL ++ F L +E ++ K V L ++++++ Y T +LK L++ D+ KK + + +FR+S+ ++ ++L+ WF LM+D+L+N AG L LY I + GP + T +++Y+L+E LL + ++ V VLDCD I+Q K K + Y+ PYS+ S L +N V + S + P K L TL Y++ + + +A + SL N + +S S ++L S +S+ T S D + H + S H +Q+ + Y T++ ++K ++ I +L + IF S +P + +F + D +V A KSN+L LRFW+ LI N F+FD+ K T V CL V++ LMD CS +D LT+ LF+ + Y V +YY I
Sbjct: 10 LYVAGVNYLYDLHSSDLSVRVEA-VTGPMDDS------DQCKGG-------RNDSCTAIRHKTNSHAKALAVYDKSSQLIECTSLFQGRCRLRNLHN-ISDVQIESPEPMIANDAGSSAVVFVGMGPSREPVLYVGTTFVKGPLFRD-DIPAVTSLRLSRGDGEAKEFELA---DKGLATGTEISLERKFRSSYRI-DYVGGFESGRYAYFATRQGATIGE--DAPIQSRLVRVCTGDAHFYSYTEVPLEC-IKHDINYNLIQDVYVATAGYNLA------------KSLGISEGDEVLYGVFVADDMTSFQRNFPTRRSAV-CVYPIQKHVEKKFEENIMECYR---------GKNLKQLPW-FKSSDG--CKGTHLSWKDVECG-QDVNKNIGGG----KPISAEPLLTVDDAR-FTAIAINTTRGATVAFIGTDDGRLLKTIIHDSDTAEVYATEEISPNHEPILADLDFSENGQYAYVLTPSKVVKMRTSNCGEGAATCVTCLAKRDPFCGWCVKNSICTEEDTCEKVLPKTSSGWLDFQNNR----CPNIKGVVPDKIQITTADYLNVS-----------LENMGDIKGRLQCSFRFADGKVVNSEPARQDPHDGTLRCATPPINRLPMIPPNESHHLATLSIVAEGRITPIASTNFSFYDCNRYTSCSTCAKSEFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNREGHSRRKGPQKCPHIVAPHTKLYVAAGERRNITVKVQNLDPIF--MTEFRC------QFRVGSVEHEKPAVKTFD-------DNIICDEMQFDHYGLGLAGGT---APVEFSVVWSSSESSKKHTLDNVGGVAVEVYKCEALASNCGRCLTLDATKYECGWCAIDNRCVRPMACLAKSPQDWLNST-QLCANPAIEEFSPKKGPVGGKTKLRITGSNLGRRYQDVSGAVIVANVH----CAVIPAEYQPATEIVCETGKAAIKNSKGPIVVRLRADDANYAAVSKYDFEYVEPGVSAVKPNRGPKSGGTDVTLYGTDLDAGS--EVHVSFGE--VKCEVLSRKPDQLICRMGAMDSDMGVSSSKPLRLDFDGSPGRVPYQLT------------YEFVSNPRVSTIVPAKSIAAGGVQIDVKGEGFALLQRPRMVLINDRGVIQAGPVCEVEDDGLMVCLSPGLPSGDTGGRLHHNFAFDFDGTITESRQMEVYPNPKVDQFAETRFYRPGD-------NYLTIN---GDDLNVGAMER-DIKITVGGVDCQLTALARKVLTCK-------PPTEKPNLEGGLQPEVVVKIGNISFNAGQLSYDSPSLTSGIVMVILGCIIAMLVCFVCLAIMYRRKTNSHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPIVPFLDYKDYCARVLFP---------------------------NNPHNHPVLRDLEVDSQKAGAIEAGLREFHKLLMNKTFFLTMVRTMESNKYFLGKDRVYVGSLIMVVLQEKMGYCTEMLKQLLRELIDRTVEKKF--QPKILFRRSESVAERMLAAWFTFLMHDYLRNF-AGKRLYDLYWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELTIFIAADSMTYTQPDMPVRVLDCDTITQVKEKCLDAKYRTVPYSDRPSANDLDLEWRTGINGRMVLQDIDSTSRVEPGGWKR-----LNTLGHYNVPNNSVLMLATRQNSL--YNLSLLSE-RSEKSTLSLKNSPTLSRPWVGTNSSSNSKDAEGQKLYHLVKPSEHGPTENQEKMVTEIYLTRL-----------------LMMKGTLQKFINDLLEAIFSTSSRSAPLPAAIKYMFDFMDEQALEHGITDAEVVHAWKSNALPLRFWVNLIKNPHFVFDIQ--KPTKVEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDWVDSYYSDI 1787
BLAST of plexin A vs. TrEMBL
Match: A0A016RT13 (Sema domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0392.g578 PE=4 SV=1) HSP 1 Score: 306.605 bits (784), Expect = 4.764e-80 Identity = 458/1966 (23.30%), Postives = 780/1966 (39.67%), Query Frame = 2
Query: 206 ILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRI--KLTDVFVKLWTFAD--SYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLY-----HDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAE---------IMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFE-DTNYLFSTENLFNN---ISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGT-NCEDCL-RVSPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLI-NVIPSH---SILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLIND--SHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNFEI----------QNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEF-----------------------QVFDCLKLSEHCDDCVHLPQI-YKCGFCTVKDKCVQKHIC-GNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDR-IETPVAFQFKFKTKDKYLVSK-EFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFE-----VKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPS-VAFRCETFLSIYENCFVNNSDID-CISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTP-VLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXX-----XXXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIE-NTVEYS-RKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXX-XXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCL---IKLNQDEVPE---SERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMT---SFLPDISKRIPIHRLSDSLH-ENSSQKSKIKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYES----VPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGI 5722
+ V+G NY+ ++L + TGP++ S +QC+ D C T+ K D S L+ C +FQG C + +L+N S ++ ND + V + L+ +R+ D ++ L ++ K + G E +F S+ I D Y +F Q E + Q RLVR+C+ D + S+ ++ + C I + Y + VA ++A K+ S+ ++L+ F +T+ R T S V C YPI + IME Y ++ + P+ FKS+D + S ECG ++ NK I G I +++ + + ++ I + T+A IG +DG L K + + DT +++TE + N I ++ +EN Y + SK+++ NC G C CL + PFCGWC+ N C +D C T++ WL FQ NR CP I V+P + +Y N S L + + L+C F + + + + A H+ +L C P +P I N++ L ++ + + + Y+C +C+ C ++F C WC+ N C++ L KC+K + + CP + + L G +I + +N F T+F C +GS+ V TF +I C G L G P+EF +V+ C L+ +C C+ L Y+CG+C + ++CV+ C W+NS Q C P+I E P + ++ + + G NLG DV A+ + N H C I Y + + C+ + + P+ + + + VSK +F++ P V +++PN GP GGT + + G+ L+ GS EV ++G + C +L + + + CR+ + K +R +P + QL +EF NP V I K ++ GG + G+ L +P V + C V + + C+SP + + FA + + + ++ P V + + P + +TIN D ++V A + D KI VG + C + + C K + + V+ G I F G +S D+ S+ I ++++ I +LV ++ +K S QR +++ K + T K+ E E LNQ ++ P Y Y LFP N+P HP++ + ++ + +E R+ KL ++ F L +E ++ K V L ++++++ Y T +LK L++ D+ KK + + +FR+S+ ++ ++L+ WF LM+D+L+N AG L LY I + GP + T +++Y+L+E LL + ++ V VLDCD I+Q K K + Y+ PYS+ S L +N V + S + P K L TL Y++ + + +A + SL N + +S S ++L S +S+ T S D + H + S H +Q+ + Y T++ ++K ++ I +L + IF S +P + +F + D +V A KSN+L LRFW+ LI N F+FD+ K T V CL V++ LMD CS +D LT+ LF+ + Y V +YY I
Sbjct: 15 LYVAGVNYLYDLHSSDLSVRVEA-VTGPMDDS------DQCKGG-------RNDSCTAIRHKTNSHAKALAVYDKSSQLIECTSLFQGRCRLRNLHN-ISDVQIESPEPMIANDAGSSAVVFVGMGPSREPVLYVGTTFVKGPLFRD-DIPAVTSLRLSRGDGEAKEFELA---DKGLATGTEISLERKFRSSYRI-DYVGGFESGRYAYFATRQGATIGE--DAPIQSRLVRVCTGDAHFYSYTEVPLEC-IKHDINYNLIQDVYVATAGYNLA------------KSLGISEGDEVLYGVFVADDMTSFQRNFPTRRSAV-CVYPIQKHVEKKFEENIMECYR---------GKNLKQLPW-FKSSDG--CKGTHLSWKDVECG-QDVNKNIGGG----KPISAEPLLTVDDAR-FTAIAINTTRGATVAFIGTDDGRLLKTIIHDSDTAEVYATEEISPNHEPILADLDFSENGQYAYVLTPSKVVKMRTSNCGEGAATCVTCLAKRDPFCGWCVKNSICTEEDTCEKVLPKTSSGWLDFQNNR----CPNIKGVVPDKIQITTADYLNVS-----------LENMGDIKGRLQCSFRFADGKVVNSEPARQDPHDGTLRCATPPINRLPMIPPNESHHLATLSIVAEGRITPIASTNFSFYDCNRYTSCSTCAKSEFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNREGHSRRKGPQKCPHIVAPHTKLYVAAGERRNITVKVQNLDPIF--MTEFRC------QFRVGSVEHEKPAVKTFD-------DNIICDEMQFDHYGLGLAGGT---APVEFSVVWSSSESSKKHTLDNVGGVAVEVYKCEALASNCGRCLTLDATKYECGWCAIDNRCVRPMACLAKSPQDWLNST-QLCANPAIEEFSPKKGPVGGKTKLRITGSNLGRRYQDVSGAVIVANVH----CAVIPAEYQPATEIVCETGKAAIKNSKGPIVVRLRADDANYAAVSKYDFEYVEPGVSAVKPNRGPKSGGTDVTLYGTDLDAGS--EVHVSFGE--VKCEVLSRKPDQLICRMGAMDSDMGVSSSKPLRLDFDGSPGRVPYQLT------------YEFVSNPRVSTIVPAKSIAAGGVQIDVKGEGFALLQRPRMVLINDRGVIQAGPVCEVEDDGLMVCLSPGLPSGDTGGRLHHNFAFDFDGTITESRQMEVYPNPKVDQFAETRFYRPGD-------NYLTIN---GDDLNVGAMER-DIKITVGGVDCQLTALARKVLTCK-------PPTEKPNLEGGLQPEVVVKIGNISFNAGQLSYDSPSLTSGIVMVILGCIIAMLVCFVCLAIMYRRKTNSHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPIVPFLDYKDYCARVLFP---------------------------NNPHNHPVLRDLEVDSQKAGAIEAGLREFHKLLMNKTFFLTMVRTMESNKYFLGKDRVYVGSLIMVVLQEKMGYCTEMLKQLLRELIDRTVEKKF--QPKILFRRSESVAERMLAAWFTFLMHDYLRNF-AGKRLYDLYWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELTIFIAADSMTYTQPDMPVRVLDCDTITQVKEKCLDAKYRTVPYSDRPSANDLDLEWRTGINGRMVLQDIDSTSRVEPGGWKR-----LNTLGHYNVPNNSVLMLATRQNSL--YNLSLLSE-RSEKSTLSLKNSPTLSRPWVGTNSSSNSKDAEGQKLYHLVKPSEHGPTENQEKMVTEIYLTRL-----------------LMMKGTLQKFINDLLEAIFSTSSRSAPLPAAIKYMFDFMDEQALEHGITDAEVVHAWKSNALPLRFWVNLIKNPHFVFDIQ--KPTKVEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDWVDSYYSDI 1792
BLAST of plexin A vs. TrEMBL
Match: A0A183UAV3 (Sema domain-containing protein OS=Toxocara canis OX=6265 GN=TCNE_LOCUS5623 PE=4 SV=1) HSP 1 Score: 301.597 bits (771), Expect = 1.693e-78 Identity = 439/1890 (23.23%), Postives = 780/1890 (41.27%), Query Frame = 2
Query: 422 SYLVVCYDVFQGFCEIIDLYN-QFSSSYKNKAYSIVTNDRKFHSTVLYHDQR-----------LFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHI-----YDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQV--RLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDT-NYLFSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAM------WLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFT-----SNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVL--INDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF---EIQNNQPD-------CPTLEVSNETLSFHV--GFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKV------LQKASIKCSMKVSWILGNLLTGS-IETETPIEFQVFDCLKLSEHCDDCVHLP-QIYKCGFCTVKDKCVQKHIC---GNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQ--NINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDI-DCISP-------TTSNITQFQKCSLLFAMEKGSVCVYNTS-------ITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYH-KYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQA--AIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQV-IENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXX-XXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSS-------FESYCLIKLNQDEVPESERLLAPIALKEVVGY-TLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDG-HHLKPACLIY-TQVL--KSKIEGQIKNLFDDIFDYE----SVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGIKGTGSFN 5743
S L+ C +FQG C +LYN + ++V NDR F STV++ L+ A+ +Y + D ++ LS T F D Q V G E +F G + I + S + + +F QP+ + P F + +LVR+C+ D + S+ ++ + C N+ TY + ++ D+A S + ++ D IL+ F + + T +S + C YP+A + ++ + N+ + G ++N FKS + RC + F +G+ GK+ N +I GD ++ V++ + ++ + + T+A IG +DG L K + T +++ T + + ++ ++ +Y + S + + +R+C +CE CL + P+CGWC+ N CV + +CT ++ WL F+ + CP+I + P + S + L+I N L + T N + + + + C P +P I + +L + I+ L + Y+C+ +C CV++ F C WC+ + C++ + +C+ + N P CP + V++E L F+V G I + KN ++ TDF C ++S L+ V ++MK + + V W G ++ I ++ C L+ C C+ L + ++CG+C+ + +C + C G DD W+N + Q CP P I + P L+ + + + G NLG DV A+T N C + Y+++ + C+ + ++ P+ + + + K + ++ F + P V IEP G GGT + + G ++ GS V N G+ I C ILE + + CR S N S L +D ++ + + +F++ P + ++ + +++GG + + G L +P + E C ++ D+ C +P ++ T L + E V N S + +F PV+ + S + +TIN + D +A + D + VG C + + C +++ Y + ++ + +G V G + + D + +I I+ ++ +I IL++V +K S R N + +K A E K AEL + A+ ++ P Y Y LFPN + N P L V+ Q + IE + R +KL + F+L F +E+++ K + + S L ++LM+ + T ILK L+K D+ KK + + +FR+S+ ++ ++L+ W+ LM+ +L+ AG L LY I + GP + T +++Y+L+E LL + + + SE V VLDCD I+Q K K + Y+ +P+S+ S S C + QD + E G+ + TL Y + D + + + SL + SL + +S + + S P +++ + S S S+ +S K + K S H K IY T++L K ++ IK+L + IF S C+ +F ++ + DD +V A KSNSL LRFW+ LI N F+FD+ K T V CL V++ LMD CS +D LT+ LF+ + +Y V NYY I+ S +
Sbjct: 138 SKLIECSSLFQGRCRWRNLYNIDQKDVIRESQRNVVANDR-FSSTVIFVGAGPPNDDGIPKDVLYVASTYAQNGSYWD-DVPAVASLSLAQETLF--DVSVQG-----VGTGTEIKMERQFRGQYKIEYIGGFQSGR------FAYFATRQPKG-YIPGGNTFPIISKLVRVCTEDAHFWSYTEVPLECSRGNE-TYNLMTDVYLSKPGYDLA---------SSLGISVEED---ILYGVFVEGVGVDKSIPTSHSAL-CVYPMAAVERIF--LDNIEICFRGENDKNLPWFKSAE-RCQQTKF--SGQEVLCGKDVNSYIGGDI----AVEARPVLTTKDAR-FTAVATNTTRANTVAFIGTHDGRLLKGVIENRTAGFIYRTVEIGGGKPVLQDLELDGTGDHVYVLTPSSVSKVKVRHCGGAGDCESCLAQRDPYCGWCVLNNGCVPEGECTKSIPSTPHDWLTFRTGK----CPIIRSV-----------EPDKMQITSASYLNIELGNLPNLGGQMTCIFDFGNASGPVTMIAEQSGSSESRVRCPTPSLTRLPKIPAESQSLSARLAIAGGIDGPPLAFTNFTFYDCSRFMSCGSCVSSAFPCDWCIESDQCVAGTTTENRCRAQHIVNGLARNGPSRRKGPSHCPHM-VADE-LEFYVASGKTRQISVRAKNVLDFM---TDFKCQFKIEHSVH-ERLARKQGDVIICEVMKFDYYGPGTGNGTAIANFSVIWSTEGQQGGHLLDNNQGIRVVIYKCELLASSCGLCLALSDKKFECGWCSSERQCTRLEKCPADGPDD--WLN-RTQLCPYPVITDFNPKKGPLAGRTQLTIDGVNLGRSYQDVAGAVTAAN----VRCDVDQDLYVTASRIVCRTRPSPVHKTARNPIVVKLRDEHKYTAISNESFTYVDPLVTRIEPLKGTKYGGTDVTIWGENMDAGSLVNVTINVGSNRITCEILERTNDRLVCRSGP------------SINDSDGSFSLTVDGSTQIYDNFRFKYEKAPTISQVRFERSIASGGILVDVYGSGFKLLQRPHMVVMDEDRAIKGPKCIIDRDDLMQCYTPDLMMPHDRRNHPTIEHPLMLDYGFEMDGVRPGNISQLSGFNRLEVFPDPVIERFADGRSYRSG-------DYLTINGKYLD----AAASERDVLVTVGGETCNLTALANRALTCLPPDLSSDQFYGIRPRVIVKIGGMNYDV-GELSYNSKDSDISPQVLIAILIAVLAVICAFILLLVFYRRKSTSHMREMKHLRNQIDQIEMKVATEC-KEAFAELQTSMNALAADLPLGVPFIPFLSYKQYTARVLFPNNYH-----------------------NHPVLRDLEVDSQRALSIETGL---RSFNKLLMNRHFLLSFVRAMENNKYFLGKDRVTVGSLLMVVLMEKMEYCTEILKQLLKELIDRTVEKKF--QPKILFRRSESVAERMLAAWYTFLMHRYLRE-RAGQKLYELYWAIKQQVEKGPQDAITLEARYSLSEEKLLRSSFDFRELIVFIAADNYTAGVSEYPVRVLDCDTITQVKEKCLDAKYRTTPFSDRPSANELDLELRSACPRIILQD--------FDSTSRVEAGGWKRVNTLAHYKVLDNATLALLPRQASL-------------YNLSLLSERSERSTFSLSKQS--PTLARPFGTNSSSQSKGLLSNMESNYKLYHLVKPSEHGPSDHQDKMVTEIYLTRLLTMKGTLQKFIKDLLEVIFSTSDHNGSFAPCIKYMFDFMDDQAREHGIEDDEVVHAWKSNSLPLRFWVNLIKNPHFVFDIQ--KPTKVEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYVYREWVNNYYCEIRSMPSIS 1877
BLAST of plexin A vs. TrEMBL
Match: A8XIW2 (Protein CBR-PLX-1 OS=Caenorhabditis briggsae OX=6238 GN=plx-1 PE=4 SV=2) HSP 1 Score: 301.597 bits (771), Expect = 2.104e-78 Identity = 415/1772 (23.42%), Postives = 717/1772 (40.46%), Query Frame = 2
Query: 725 ETIFPLEFVGSFHIYDSRKDAFFK------------NYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYR--ETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTG-KGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFED--TNYLFSTENLFNN--ISFNMVVNENKSVIYAVADSKIIRHNLRNCYN-GTNCEDCLRV-SPFCGWCISNGKCVVKDQC------TTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGI--YHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSL--GKCKKNF-------------EIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNST--AIGSLSASNRLVCTFQMMK-----VLQKASIKCSMKVSWI-LG-----NLLTGSIETETPIEFQVFDCLKLSEHCDDCVHL-PQIYKCGFCTVKDKCVQKHICGNDD--SKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKE-FKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYEN--CFVNNSDIDCISPTTSNI---TQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLR-INPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXX-----XXXXKKVQSKQR-LRHEKENIFT--EKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESKKSDIVSFLSLILMKDLPNY-TRILKILIKNDYDK---KKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCL-------IKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKS----KIKCCYKTKISAFKDGHHLKPACLIYTQVL--KSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ-------LFSDVIKLYSPKVLNYYEGI 5722
E +FP + G+ D R ++K +Y +F+ Q + H+ + Q RL R+C+ D +Y S+ ++ + C T V +V +V A + K+ + D + I + K N+YR + C + + E+ + C G+ + +N F S D C FT+ +G GK+ N I GD S ++ + Q + I + T+A +G G L+K L E + ++TE L +N I +M + + IY + SK+I+ C + C+ CL PFCGWC+SN C ++ C T+ WL FQ ++ CP I + I + V + + P + ++C F + + + + SL C P +P IA N+ + KL V+ + S L + Y+C +C+ C ++F C WC+ N C++ L KC+K I+ CP + +S G +I + +N F DF C T I ++ + + C + + +L S V W LG + ++ + V+ C L+ +C C+ L + Y CG+C+ DKC + H C N + W+NS Q CP P I + P ++ + + + G NLG + DV+ A+ + N + +Y+ S I K I+ N+R VA + + + V+ E F + P V S++P GP GGT + + G L+ GS VKF I C +LE ++ CR+ E + L + D + FEF +P V+ I+ NK + +GG + G L +P + F Y +++ + C +PT TQ +K + +A + +Y + I I P +N + P + + A + D + VG C + + C K Q + + ++ G F G++S D+ + + + ++I I ++ + V+ +K + QR +++ K + T K+ E E LNQ ++ TAP +Y Y LFPN HP++ N ++ + V R+ KL ++ F+L +E ++ K V L ++++++ Y T +LK L++ +K KK + + +FR+S+ ++ ++L+ WF L++DHL+ +AG L L+ I + GP + T +++Y+L+E LL E+K+L + V ++ V VLDCD I+Q K K + Y+ +++ L K+ ++ S R+ + L TL Y++ + + + K+ SL N + S + + S+ ++KS K + S P P +D H +SS + K+ K D + T++L K + I +L ++IF +VP C+ +F + + D +V A KSN+L LRFW+ LI N FLFD+ K T + CL V++ LMD CS +D LT+ LF+ + Y V +YY I
Sbjct: 211 EIVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRKTIHD--DSPIQSRLARVCTGDKNYHSYTEVPLEC------TRNGVDFNLVQDVYVTRAGYELAKSLDISVS---DPVLYGIFWEGDK-----NSYRSADATGKSAICIFTMKEVELAFKQNIMKCYKGTSGLKKNLPWFSSNDD-CR---FTTLPWEGIKCGKDVNSKIGGDTPIATSAT---YVTDDSAQLLTSIAINTTRSSTVAFVGTQGGKLHKL-LIESKRSAERYATELLTDNEPILADMEFSGDGKHIYILTPSKVIKMPTSRCETLSSQCDTCLSSRDPFCGWCVSNNHCTQEESCEREVPHTSRGWLDFQNSK----CPRIRSVKPDQIQINTADYLNVTIENLQAP------KGRRMQCLFQFPTGDSVVSDPMPF---DGSLKCATPPMNRLPRIATNEYHLAAKLVVVSDGSKLPLATTNFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNVSLRDGSSIRKGPSKCPHIVAPVSKMSVATGERRNISVKVENVDPSFMG--DFKCEFRYGTVTHEKIAMRTSEDTITCDEMLFEPYGTSLLGSGSTPYGFNVIWTALGAPQVKKSINRFLDNVDQLSIDVYSCENLAPNCGKCLTLDSEKYDCGWCSHLDKCTRPHQCPNRNLAENWLNSS-QLCPNPQIEDFKPRKGSIFGGTRVTITGINLGRHVADVEKAVQIANVPCEVV-EYVPSSKIVCLTGKSTIKGSNER--GVVAVTLRHDSLKFFAVTSEKFSYVEPVVSSMKPVKGPRSGGTDVVLTGIDLDTGSEIMVKFGQ----IECKVLERTSEWLKCRMGPSEEGGQF------------PLHIAFDGQLQNLPIAIYFEFTSDPSVQSIAPNKTIPSGGITVDVYGQGFTLLQRPRMVFVGLGNDKSYGPLCSIIDDQLMKCATPTVPGAARDTQVEKIT-DYAFDFDGAELYRSKIKIMPPPSFEMLNEPRFVRPGDDFLTLNG-----------NNLNLAASERDIDVKVGGESCPLTALANKILTCQ-------PPVKKPQGAGKLNPEIVVTVGNASFSVGEVSYDSPGLSSSLLLAILIFIIAMIGLIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTA--DLPLGTPTAPFLEYKDYCARVLFPNGGK---------------------------NHPVLKNLEVDTHKAEVTGLREFHKLLMNKTFLLTMVRTMESNKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKF--QPKILFRRSESIAERMLAAWFTFLLHDHLKTFDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELTVFVNSTDSVYQQDIPVRVLDCDTITQVKEKCLDSKYRGYRFADRPGPSEMELEWKTGLNGKMTLQDIDSSSRIEGGNWKR------LNTLAHYNVPNNAILTLTSKSNSL--YNLVNFSTCSNKTTSILSDKSSLSMKTAGVGS--PKPWGGAPPSVTAD--HASSSNDTDNGYKLYHLVKPTEHGPTDSQEKMVTEIYLTRLLMMKGTLAKFITSLLENIFSAANVPPCIKYMFDFMDEQAREHGIIDPEVVHAWKSNALPLRFWVNLIKNPHFLFDI--QKPTKIEGCLSVVAQTLMDACS---TQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEI 1856
BLAST of plexin A vs. Ensembl Cavefish
Match: plxna1a (plexin-A1-like [Source:NCBI gene;Acc:103026658]) HSP 1 Score: 274.633 bits (701), Expect = 1.240e-73 Identity = 366/1674 (21.86%), Postives = 688/1674 (41.10%), Query Frame = 2
Query: 854 LFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCM------EDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENLFNNISF--------NMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENK---NFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQK------ASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQ--KCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIND-RIETPVAFQFKFKTKD-----KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSNITQFQKCSLLFAMEKG-------SVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSK--QRLRHEKENIFTEKII--KEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
F ++VR+C D + S+++ + C D V +V + A R ++ +R + S+ ++LF F N + C + + +I E C G G ++ P+ + + C+ ED F G++FN+ + G + I + + G + + Y T+A G G + K + N ++ L+ N++ +M+ + N IY + ++++ R + +C T+C +CL P CGWC+ + C +D+C + P + V C ++V P++ + S ++ Q P LS + C F E V H F C+ P + I PI +K + + + LK + YNC+ ++C CVN F C WC + C + C N +CP + + + + VG I L+ +N + + ++ C+ + S++A + Q K + + + + V W G + P I+ ++ C L + C C+ + CG+C + KC + C +S W++ +C P I ++ P + + + G NLG D++N + L + C +E+ YIS+++ C+I + R++ Q + +D + L + F F +P ++P+ GP GGT I + G+ LN GS V N G P CR K+ + NP + ++IDA ++ +V+F + +P V I + +++GG ++G NL + +P + + T S + NC V NNS + C++P+ ++ + S E G ++ V N S + F PV +S PT +L + + + N + + ++ + +G +C ++ + C ++ ++++++ G + + G ++L + I +++++ I +LV + + +RL+ + +N+ + + KEA L+ I EL Q I P Y Y + LFP HP++ K+++V + + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + D+ + N + + R + K+L+NWF L+Y L+ AG L +LY + + GP++ T +++Y+L+E+ L+ ++I++K L L + E+ E+ V+ L+CD I+Q K K+ + +YK SPYS K ++ + +A I L++ T L TL Y + DG I + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 285 FFTSKIVRLCVDDPKFYSYVEFPIGCTKDG------VEYRLVQD-----AYLTRPGSKLAR--SLGISEREEVLFTVFA--QGQKNRAKPPKESALCLFTMRKIKEKIKERIQSCYRGEGKLSL-PW-LLNKELACINSPLQIEDNFC--------GQDFNQPL-----GGTTTIEGIPLFLDKDDGLTSVAAYDYRGHTVAFAGTRSGRIKKIVV----NSVYQPAQLYENVAVSEGNPILRDMLFSPNYLYIYTLTENEVSRVPVESCEQYTSCNECLGSGDPHCGWCVLHNTCSRRDRCERSEE-PLRFASHVGQCVKLSVQPNNVSVTMSEVQ--LVLQAQNVP--SLSAG---VNCSFEDYTETEGHIVGGHIF-------CLTPTTRQIAPITRSKGDRHVMKVYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHMCTHDA-NDCSFQEGRVNTSEECPQIMPTTQ-IHIPVGVIKPITLLAQNLPQPQSGQRNYECIFNIQGR--VHSVTALRFNSTSIQCQKTMYDYDGNDISDLPVELSVVW------NGDFVIDNPYNIKAHLYKCYALRDSCGMCLKADPRFDCGWCVQEKKCSLRQECAPAESTWMHPSISNSRCTHPKITKLFPETGPRQGGTRLTITGENLGLQFTDIQNGVRLG----KVPCIPVEEEYISAERIVCQINDATGYRVQEA---QVEVCVRDCLPDYRALSPRGFTFVTPFFTRVQPSQGPLSGGTRITIEGNHLNAGSL--VTVNIGRQP--------------CRFKKRSAKEIVCVTPAGGNPGSTPVMVDIDAAELRNPEVKFNYTEDPTVLHIEPDWSIASGGIPLTVSGTNLATIKEPKIRAKYGTAES-FHNCTVYNNSVMVCLAPSVAHSERGIAESGSRPDEIGFYMDDVDALIVVNESFSYFPDPVF----EPLS-PTGVLELKPASPLILKGR-NLFPAAPGNSRLNYTVLIGETLCV-LTLSETQLLC-----EWPNLTGQHKVTIQAGGFEYSPGTLQIYRDGLLTLPAIVGIGGGGGLLLLVIIFVLVAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGI-------PFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQADMEKALALFGQLLAKQHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDRNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAMKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVNPENESAPEVSVKCLNCDTITQVKEKLLDAVYKGSPYSQRP--------KAGDMDMEWRQSRMARIVLQDEDVTTKIDNDWKRLNTLSHYQVTDGSVIALVPKQNSAYNICNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHSDQREGDRSS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDADVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1793
BLAST of plexin A vs. Ensembl Cavefish
Match: ENSAMXT00000016691.2 (plexin A1 [Source:NCBI gene;Acc:103028361]) HSP 1 Score: 259.61 bits (662), Expect = 5.398e-69 Identity = 320/1432 (22.35%), Postives = 602/1432 (42.04%), Query Frame = 2
Query: 1541 NMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAE---NKNFVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQK------ASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIND-RIETPVAFQFKFKTKD-----KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCS--------LLFAMEKG-SVCVYNTSITIFSTPVLR-INPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVS-GYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
+++ + N+ IY + + ++ R + +C +C +CL P CGWC+ C KD+C A P + V C ++V P++ + S ++ Q P + + C F E I + C+ P K + PI +K V L LK + YNC ++C CVN F C WC + C ++ C N DCP + S + + VG I L +N + + ++ C+ T S++A + Q K + + + V W GN + I+ I+ ++ C L E C C+ ++CG+C + KC + C + W+++ +C P I+++ P + + + G NLG D++N + + + C IE+ YIS++Q C++ + R++ Q + +D + + K F F SP + P+ GP GGT I ++G LN GS VK G P C+ I C S P + ++I+A ++ +V+F + +P + +I + +++GG + G NL+ + +P + + S+ VNN+ + C++P+ + + S + F M+ ++ V N S T + PV + P + L I+K + + N ++ ++ + +G C ++ V++ + ++ L G++ +TV G ++ G + + + S++ + I+ + +L++VII+ + K++ R + +++ + + + R E + A +Q +IH+ + P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L +LY + + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD I+Q K K+ + +YK SPYS K ++ + +A I L++ T L +L Y + DG I V +N + SN+++ + L + L+T S + + PM + PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 483 DLLFSPNQQFIYTLTEKQVKRVPVESCDQYKSCSECLGSRDPHCGWCVLLNVCSRKDRCERADE-PQRFASRVDQCVELSVQPNNISVTMSEVQ--LVLQARNVP-----DLSAGVNCSFEDYTETEAR-------IQGSRIYCLSPTAKELIPITRHQGDKRVVKLYLKSKETGKKFASVDFVFYNCTVHKSCLTCVNGSFPCHWCKYRHMCTQNA-NDCSFQEGRVNMSEDCPQILPSTQ-IYIPVGVTKPITLAARNLPQPQSGQRNYECIFHIQGETH--SVTALRFNSSSIQCQKTTYNYDGNDISDLPVDLSVVWN-GNFV---IDNPYNIKAHLYKCYALRESCGMCLKADPRFECGWCVQEKKCSLRQECAAPEHTWMHATAGNSRCTHPRIIKLTPETGPRQGGTKLTITGENLGLQFRDIQNGVRIG----KVACHPIEEDYISAEQIVCRLTDATGYRVQ---EAQVEVCVRDCQPEYRAISPKAFTFVSPYFTRVVPSHGPVSGGTRITIHGIHLNAGSAVSVKI--GLNP--CHFERRSAREIVCMTP--------AGLSTGSIP----VMVDINAAELRNPEVKFNYTSDPTITRIEPDWSIASGGTPLTVIGTNLDTVKEPKMRAKYGEIKSVNNCTVVNNTVMVCLAPSVAGTDTERSLSEVGSSPDEIGFVMDNVLTLLVVNESFTYYPDPVFEPLAPTMLELKPGSPLILKGRNLIPPAAGNTRL--------NYTVLIGDEPC-------------VLTVSETQLLCEW--PNLTGQHKVTVRVGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIIVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVPANVEKALTLFGQLLNKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMSALQGEMEYATGVLKQLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAMKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVNPENENAPEVTVKCLNCDTITQVKEKLLDAVYKGSPYSQRP--------KAGDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNSLAHYQVTDGSVIALVPKQNSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHSDQREGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1783
BLAST of plexin A vs. Ensembl Cavefish
Match: ENSAMXT00000046590.1 (pep primary_assembly:Astyanax_mexicanus-2.0:22:18585232:18670788:1 gene:ENSAMXG00000034599.1 transcript:ENSAMXT00000046590.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 237.269 bits (604), Expect = 3.981e-62 Identity = 353/1692 (20.86%), Postives = 675/1692 (39.89%), Query Frame = 2
Query: 797 NYIFFLVNQPENKH---EPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEI-MELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENLF---NNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHIYNCAHSR---------TCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQ--KCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQN--INDRIETPVAFQF---KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTD-VQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVT-INLEVNDQI-SVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSK-----QRLRHEKENIFTEKII--KEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFP--NTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGP-VNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMK-----NESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
++++FL QPE P + R+VR+C D+ + S++ + + C + Y + + +A +A K S+ +LF F Y+ + C + I +I + + +R+ C G G N + D +C ++D F G + N+ + G + GH V + + S+ + IY + +A +G G + K + ++ T + ++I +M + N +Y V+ +++ + + C + C +CL P CGWC+ + KC+ +D+C + L F+ ++ C + P + S S ++ +VS P + + C F + +A V+ H ++ + + C+ P + IP I ++++ ++LKV L +Y I + + C CV++ F C WC N+C C N CP LE E + G I L +N + + + C+ TA+ S S + + + + L+ + + + + W N + I+ I+ Q++ C E C C+ + + CG+C + +C + C + +W+ KC P I E+ P +++ ++G NLG ++++ + + C + YI+++Q C++ + ++ R P Q + + + + L S+ + F +P V + P GP GGT + + G L+ GS ++F T C + I C F S + S+ + ++ + + + + F++ +P V++I +++G +TG NL+ + +P V + S+ VN + I C +P+ + S+ A E G V ++ F++ PN P +L +++QK + I L+ + + S + ++ + VG C +++ + + C E + HK I + +L G +Q + SL + I I ++FII+++V+I ++ + +RL+ + +N+ + + KEA L+ I EL + I P Y Y + LFP + HP L C Q +E + ++ ++L ++ F+L F LE + + + + S + L L T +LK L+ + K + N + + R + K+L+NWF L++ L+ +N +L + L++ VN + NENS +E+ V+VL+CD I+Q K KI + +YK PYS W + ++ ++D + E L TL Y + D + + K N S AS S S ++ S ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS ++++
Sbjct: 261 DFVYFLTVQPETSDAGGSPAELFYTSRIVRLCKGDNKFHSYVSLPIGC-VRKGVEYRLLQAAYLAKAGSVLA------------KALNVSEQDDVLFAVFS--KGQKQYQRPSDDSALCLFTIRDINARIKERLRS-CYQGEG--NLELHWLLGKDVQCTKAPVPIDDHFC--------GLDINQPLGGSEL----VTGHTVYTETSERLTSVSAY-IYNGYCIAFLGTRAGNIRKVRVDGSVGAVYETVRVMKDGSSILPDMAFSLNHHHLYTVSQTQVTQVPVEYCEQYSRCVECLSSGDPHCGWCVLHNKCMRRDRCERSDEL-FRFADEIERCVKVTAHPDS--IAMSEHSVPLLLEVSNVP-----DLSAGISCLFGN-----LAEVEGH--VNENRVMCLSPTAREIPVIPADQDWSGVELKVF----QLFFSVYFIVTGVNIKFTGISITFKVCLSCVSSAFRCHWCKYRNTCTHDPT-SCSFQEGHVNASEFCPQLERGGEIV-IPAGEIRPITLRARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSTSVQCQNSSYVYEGLKLSELAVDLSIVWN-SNFI---IDNPERIKVQLYKCSAQRESCGMCLKADRRFGCGWCAGESRCTLRKHCPSLAGRWLEPSGHNSKCTHPRITEVTPLTGPPEGGTLVTIRGVNLGMTLSELQGRVEVAG----VPCSAQSEGYITAEQVVCEMDSTAVSSR---PGPVQLCVGECRPELRTLSSQLYTFVTPSVLGLTPARGPVSGGTKVTIVGDHLDSGSSVHIRFGNET----CEFYRRSFSEIVC-------------FSAPSVGGEGSVDVRVNVDQAELSSTLTFQYIEDPTVQRIEPEWSITSGHTTLTVTGTNLDVVQEPRVRVKYAGHESVNVCKVVNTTTISCFAPSLMADLAPGQDSVKHADEFGFVFNNVQALLTFNSTSFIYYPNPSFEPLSLTGVLEQKPGSPIILKGRNLVPPASGGSRLNYSVLVGDTPC-HVTISEHQLLC---EPPALSGQHKITIQV---GGLLVSPGSVQIQSD--SLLTLPAIFSIAAGGGLLFIIVILVLIAYRRKSHENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGI-------PHLDYRTYTMRVLFPGMDDHPVLRELEVA-------------GCGQ------------QRVEKAL---KQFAQLVNNKTFLLTFIRTLELQRSFSMRDRGYLASLIMTALQARLEFATDLLKQLLSDLILKNMESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKALNIKQNLSLFCFLSLSLSQTLSCVNPD--------NENS-----------------------AEIPVKVLNCDTITQVKEKILDAVYKNIPYSQRPRAVDMDLEWRQGRTARVVLQDEDITTKIENDWK----------RLNTLVHYQVSDRCVVALVPKQTSSYNISTSASFPRSFSRYDTVLRSASAGSPESMRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEAERGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHR 1769
BLAST of plexin A vs. Ensembl Cavefish
Match: plxna1a (plexin-A1-like [Source:NCBI gene;Acc:103026658]) HSP 1 Score: 206.838 bits (525), Expect = 3.041e-53 Identity = 250/1093 (22.87%), Postives = 469/1093 (42.91%), Query Frame = 2
Query: 2519 IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQ--KCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIND-RIETPVAFQFKFKTKD-----KYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFV-NNSDIDCISPTTSNITQFQKCSLLFAMEKG-------SVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSK--QRLRHEKENIFTEKII--KEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNICVAMKNESL-----PASNTASVSHLESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
I+ ++ C L + C C+ + CG+C + KC + C +S W++ +C P I ++ P + + + G NLG D++N + L + C +E+ YIS+++ C+I + R++ Q + +D + L + F F +P ++P+ GP GGT I + G+ LN GS V N G P CR K+ + NP + ++IDA ++ +V+F + +P V I + +++GG ++G NL + +P + + T S + NC V NNS + C++P+ ++ + S E G ++ V N S + F PV +S PT +L + + + N + + ++ + +G +C ++ + C ++ ++++++ G + + G ++L + I +++++ I +LV + + +RL+ + +N+ + + KEA L+ I EL Q I P Y Y + LFP HP++ K+++V + + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + D+ + N + + R + K+L+NWF L+Y L+ AG L +LY + + GP++ T +++Y+L+E+ L+ ++I++K L L + E+ E+ V+ L+CD I+Q K K+ + +YK SPYS K ++ + +A I L++ T L TL Y + DG I + K S ++ T S+S ES L+T S + + PM + PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 159 IKAHLYKCYALRDSCGMCLKADPRFDCGWCVQEKKCSLRQECAPAESTWMHPSISNSRCTHPKITKLFPETGPRQGGTRLTITGENLGLQFTDIQNGVRLG----KVPCIPVEEEYISAERIVCQINDATGYRVQEA---QVEVCVRDCLPDYRALSPRGFTFVTPFFTRVQPSQGPLSGGTRITIEGNHLNAGSL--VTVNIGRQP--------------CRFKKRSAKEIVCVTPAGGNPGSTPVMVDIDAAELRNPEVKFNYTEDPTVLHIEPDWSIASGGIPLTVSGTNLATIKEPKIRAKYGTAES-FHNCTVYNNSVMVCLAPSVAHSERGIAESGSRPDEIGFYMDDVDALIVVNESFSYFPDPVF----EPLS-PTGVLELKPASPLILKGR-NLFPAAPGNSRLNYTVLIGETLCV-LTLSETQLLC-----EWPNLTGQHKVTIQAGGFEYSPGTLQIYRDGLLTLPAIVGIGGGGGLLLLVIIFVLVAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGI-------PFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVQADMEKALALFGQLLAKQHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDRNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAMKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVNPENESAPEVSVKCLNCDTITQVKEKLLDAVYKGSPYSQRP--------KAGDMDMEWRQSRMARIVLQDEDVTTKIDNDWKRLNTLSHYQVTDGSVIALVPKQNSAYNICNSSTFTKSLSRYES---MLRTASSPDSLRSRTPMIT--PDLESGTKLWHLVKN-HDHSDQREGDRSS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDADVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KNSITDACLSVVAQTFMDSCSTSEHK 1145
BLAST of plexin A vs. Ensembl Cavefish
Match: plxna4 (plexin A4 [Source:NCBI gene;Acc:325938]) HSP 1 Score: 187.193 bits (474), Expect = 6.575e-47 Identity = 228/1078 (21.15%), Postives = 427/1078 (39.61%), Query Frame = 2
Query: 404 LWTFADSYLVVCYDVFQGFCEII---DLYNQFSSSYKNKAYSIVTNDRK--FHSTVLYHDQ---RLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRK-------DAFF------KNYIFFLVNQPENKHEPKNG--------LFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSII-GHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTENL----FNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKN---FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETL-SFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWI--NSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN-----DRIETPVA-FQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTT 3484
L + ++ L+ C ++QG C+++ DL+ +K + Y N+ F V Y D +LF A V Y FP ++ K + + G Y +F EFV S S D ++ N+++FL QPE P G ++ +LVR+C D + S++++ + C + Y + + ++ +A +K D D +F + +ET C + + EI E C G G+++ K D C T NF + G + ++ G + S + + S+I + +Y+ +LA +G G L K + + E + I +M + ++ +Y ++++++ R + C ++C +CL P CGWC+ + C K++C + P + +K C ++V PS+ + S S T++ + P E + C F ++A + + + ++C P K +P I ++ V L LK + YNC+ ++C CV + + C WC ++C C + Q +CP L ++ L +V PI+ L KN + + + C+ T A+ S+S + T ++ +S+ + V W G+ SI+ T + ++ C E C C+ ++ C +C + +C K C + S W+ N KC P I +I P +++ ++G NLG ++++ ++ + + C + + YI ++Q C++ ++ V Q +F K SK + F P++ +++PN GP GGTI+ + GS L+ GS + F C +I+C + ++ + +D IQ D++FE+ +P + K+ + +G +TG NL+ + P + + Y N N+ +SPTT
Sbjct: 122 LMDYRENRLLACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYGDSSPDKLFVATAVDGRPEY------------FPTISSRKLARNSEED-GMFAY-----VFHDEFVASMIKIPSDTFTVVPDFDIYYVYGFGSGNFVYFLTLQPEMGGGPAAGSSSAGREQVYTSKLVRLCKDDTAFNSYVEVPLGC-VKGGVEYRLLQAAYLSKAGSILAQ---------TLKVGPDDDVLYAVFSKGQ----KRRPKETSQESALCVFSLKEINERIKDRLQSCYKGEGTLDLA--WLKVKDIPCSSALLTID-------DNFCGLDMNAPLGVSEMVRGIPLFSESNDKMTSVIAY-VYKNHSLAFVGTKGGRLKKIRVDGTPHGALQYETVQVVESGPILRDMAFSADQHFLYVMSETQLTRVPVEACEQYSSCNECLGSGDPHCGWCVLHSMCTRKEKCERSSE-PRRFASNIKQCVRLSVHPSN--ISVSQYSVTLVLEAHNVP-----ELSAGVNCTF-----EDLAEMDG--LVEGNRITCSSPAEKEVPRIVVDQGDHQIVQLYLKSKETGLAFANTSFVFYNCSVHKSCLSCVGSPYQCHWCKYRHTCTHDPR-SC-------SFQRECPQLLPADRILVPVNVVKPIT--LRAKNLPQPQSGQRGYECVLTIQGVEQRVPALRFNSSSVQCQNTSYSYDGMEMSSLPVDLTVIWN-GDF---SIDNPTQNKVHLYKCDARRESCGLCLKADPLFGCVWCKAEKRCTLKQHCPHPQSMWLEHNGINSKCTHPRITKITPMRGPREGGTLVTIRGENLGLEFHEIQGSVKVA----EVECTPVAEGYIPAEQIVCEMGKAEKSQYAGNVQVCVGECQPEFMAK----TSKYYYFVVPKLMALKPNRGPVSGGTIVNITGSNLDAGSNVSIMFKDQK----CTYHRRGGQWITCH-----------SHTSTQGYGNVTVSVFVDKAHIQ-KDLRFEYVEDPTIIKLEPEWSIFSGNTPVTVTGTNLDIIQNPQIRAK-------YNNQETTNA-CQVLSPTT 1096 HSP 2 Score: 106.686 bits (265), Expect = 2.235e-22 Identity = 134/524 (25.57%), Postives = 235/524 (44.85%), Query Frame = 2
Query: 4277 HPLIVNKQIQVI-ENTVEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSN----------WSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSAS-----LK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN--------------KDV-----WLTQLFSDVIKL 5686
HP++ + ++ + VE KL +L +++F+L F LE + + + ++ S + +L L T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L L+ I + GP++ T +++Y+L+E+ L+ ++I++K L + H E E+ V+VL+CD I+Q K KI + IYK PYS+ W +I ++D + E L L Y + DN VA+ + + A N+ + S + SAS +K T ++ PM + PD+ + + L + HE+ QK + K IY T++L +K G ++ DD+F+ ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD+ W+ + +SD+ K+
Sbjct: 1334 HPVLRDLEVPGYRQEQVEKGLKLFGQLINNKVFLLSFIRTLESQRGFSMRDRGNVASLIMTVLQSKLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFSLFCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIDYKTLVVNCIHPENEKSPEIQVKVLNCDTINQVKEKILDAIYKNVPYSHRQKASDMDLEWRQGRGVRIILQDEDMTTKIESDWK----------RLNMLSHYQVP--DNAVVALVPKQVTAYNSVNNSTVSRASASKYENMIKYTGSPDSLRSRTPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGS--------------KMVSEIYLTRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHSIHDPHVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYSDINKM 1823
BLAST of plexin A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009284.1 (pep scaffold:Pmarinus_7.0:GL476385:264710:288126:-1 gene:ENSPMAG00000008378.1 transcript:ENSPMAT00000009284.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 75.0998 bits (183), Expect = 1.384e-13 Identity = 58/196 (29.59%), Postives = 105/196 (53.57%), Query Frame = 2
Query: 4340 LSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFES 4921
LS L +LF+ LE + ++ + + S L++ L L YT ILK L+ D + + + + M R+++ ++ K+L+NW + +Y L++ AG L +L+ I + GPV+ K++Y+LN+ LL ++++ L + E + ++V VLDCD I Q K KI +++Y+ PYS S ++
Sbjct: 382 LSNLLNSKLFLTTMIHTLEGQPKFSARDRGCVASLLTVALQDKLEYYTDILKTLL-GDLVGQYVAKNPKLMLRRTETVAEKMLTNWMSVCLYKFLKD-TAGEPLFMLFRAIKQQVEKGPVDGVLRKAKYSLNDTRLLGEDVDYQSLVINATVENSGEEGPVIVRVLDCDSIGQVKDKILDQVYRNVPYSQRPSVDT 575
BLAST of plexin A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006110.1 (pep scaffold:Pmarinus_7.0:GL484765:748:3341:1 gene:ENSPMAG00000005524.1 transcript:ENSPMAT00000006110.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 54.299 bits (129), Expect = 1.082e-7 Identity = 33/114 (28.95%), Postives = 58/114 (50.88%), Query Frame = 2
Query: 5342 TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFN-----NICKDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
T++L +K G ++ DD+F+ ++PL + +F + + D ++ KSNSL LRFW+ +I N F+FD+ T CL V++ MD CS ++++
Sbjct: 72 TRLLATK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADRHAIHDPAVRHTWKSNSLPLRFWVNVIKNPQFVFDIHKTSITDA--CLSVVAQTFMDSCSTSEHR 181
BLAST of plexin A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007728.1 (pep scaffold:Pmarinus_7.0:GL483331:9686:16681:-1 gene:ENSPMAG00000006984.1 transcript:ENSPMAT00000007728.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 48.9062 bits (115), Expect = 4.269e-6 Identity = 44/162 (27.16%), Postives = 72/162 (44.44%), Query Frame = 2
Query: 5282 KTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDY-----ESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK---DVWLTQ-LFSDVIKLYSPKVLNYYEGIK 5725
++K S+ +D K IY L S ++G ++ DD F VP V F + + D + K+NSL LRFW+ ++ N +F+FDV + V L +++ MD C+ + K D + + L++ I Y V YY I+
Sbjct: 1 RSKRSSMRDRDRTKVIPEIYLTRLLS-MKGILQKFVDDFFRVVLSTSRPVPPAVKYFFDFLDEAAERHGIEDPETIHIWKTNSLPLRFWVNILKNPNFVFDVQV--SDIVDASLSVIAQTFMDSCTTQEQKLGRDSPINKLLYAREISGYKKMVEKYYADIR 159
BLAST of plexin A vs. Ensembl Nematostella
Match: EDO39009 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBD7]) HSP 1 Score: 239.58 bits (610), Expect = 3.039e-63 Identity = 413/1983 (20.83%), Postives = 772/1983 (38.93%), Query Frame = 2
Query: 80 FLILSVINIFITEICALTSEIFVYKYENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMC-TEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVL--YHDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMED------GFTSTGKGECGGKNFNKF--IIGDHY---GENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYELFEDTNYLFSTEN---LFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQ-RNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKN--FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQN-----NQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQKA--SIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSK--------QFKCK--------IQNINDRIETPVAFQFKFKTKDKYL---VSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFR---CETFLSIYENCF-VNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVC----VYNTSITIFSTPVLRINPNKISLP-TNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRC------NIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISL--------DNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKE-----NIFTEKIIKEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDKKKLNEEERSMFRQSDLLS-KLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYTLKTLKDYDIKDGDNICVAMKNESLPASNTASVSHLESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLS-DSLHENSSQKSKIKCC-YKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQ--IKNLFDDIFDYE-SVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNKDVWLTQ----LFSDVIKLYSPKVLNYYEGIKGTGSFNYNE 5752
+ +L +++ C SE FV ++ + I++ N S ++ + G N IL +E +L E L TGP++ + C P+ C S P+ + + ++ ++ L D ++ + LV C ++ G C++ DL N S + + + + +N + + D+ L+FA ++S LS F Q ++ K + F + ++ F D F ++ +K++ + +++ +L +C D ++++++I + C Y S VA ++A R+ SD +LF+ F TNN + S A LC ++++ F++ K C E + G G C + + I +Y G ++ + N + + ++E T ++G +G L K + + + + N L N+ + + ++++++ +YA D K+I+H ++ C + CE C R PFCGWC KC VK +C + P + K +++ P S + + + L L+ + + +C NN+ V+ I+++++ C P +P I V+L L V Y+C + C C + ++C WC C S C + CP L + N T + L ++ N+ L +G+ S+ + + A ++ ++V W +L + ++ ++ C C C++ +KCG+C + KC+ K C + W++ P I P S + + + G+ G +D++N + ++N + C YI S+ +F K I+ + + +P + + L S +F + +P +Y P GP GGT + + G LN G R + G P I N + I C K + R +R + +Q+ D +F F +P V IS K GG + G + P + + + S E C V+N+++ C SP N+T+F +++ GS + + + + L I N LP N R +K+ + I + D +S + D + VG + C + C + EVN ++Y V+ +GY++F G + M+ I I + +++++ ++ + + +Q RH K+ + K+ KE E AEL + + P + Y L LFP H + K + + RK S+L ++ F+L+F +E + K + ++ S L + L + T IL L+ + K + + R+++ ++ KLL+NW MY+HL+ + +G L +++ I + GPV+ T +++Y+L+E+ + + + FE+ +V VLDCD +SQAK K+ + +YK P+S+ E+ L D + R ++ E L TL Y + DG N+ ++ + +S ++ ++ + +P F P PI R S + L E +K Y T D H K IY T++L +K Q + LF+ +F+ P+ V LF ++ K D ++ K+NSL LRFWI ++ N +F+FD+ K V CL ++++ MD CS ++++ + L++ I Y +V +Y+ I S + E
Sbjct: 6 WTLLLLVSFICNSSCTAISE-FV-SHDKITNIVVDN--STGNVFIGGTN-ILVKTEADL-EVLVNTTTGPIDDNENCLPAPSYCDPSKYPR-VPTDNRNKLLLID-------YSSTQLVTCGSIYHGVCQLRDL-NTLSVTELSSSITASSNVKPAVGFIAPGGRDEVLYFATSWRKAFGDLYSTAYSISSLSLDPADPFTLTNQLQGSYLKF----KDYTFDVRYIYGFSSGD------FSYFLMVQETLESHKNKKDSNIYETKLGHVCHRDKSFSTYVEIPLVCKGRTGAHYSVATSAFVAKPGLNLAR---------RLGITSQSD---VLFVTF-----TNNTGSSVASGEHSA---------------LCYFSLKAIDKG---FETNIKNCSEGQIPLGMPWARNGDGACKKEEYLSMCNIGTSNYPISGTGGVVALAGLEWNRKPVLTSVTAMVHEAHTAVVLGTYNGHLIKISVGDGSKLVIPYYNKGLLPGNVIWKLDLSKDRTAVYATTDFKVIKHPIQECSTFSTCESCSGRGDPFCGWCTLYNKCSVKSECADSSLSPLRFATEKSKCVSIVSTNPDKFPYGASTQ-----LEATVQNLPPLTAGNTY-QCYI---NNK----VQTTSTINSNTVKCSTPDSSGLPEITNPTGDVLVELALYSSETGQKFVVKKIPFYDCTKMKGCRPCAESVYDCDWCTYTGKCSSDGNNACPGEAILAKMKRTLGAAGCPKL-LGNTTHYVPNDVKKELVLKAQDLPALKNNFVYECVLSVEGKKLKVGATRDSDSQLSCHSGVYTYNAATQTVHMGLEVLWRGTDL----VYKPESLKVLLYKCDVAYTDCGTCLNADFNFKCGWCKSEGKCLVKQACSQN---WVHPASPCLIAPVIERFWPMAGPPSGGTELEIHGKEFGKSFSDIQNNVYVDN----YPCIPDPHKYIISQRKNRVAMFRFSVKLIIVCLTTIRIVCNTTRSPRQLRGPVRVTVSGLRGSSSADFTYQTPELYDYYPKKGPQSGGTPMNITGVKLNTG--RHIVVMVGRTPCIVNRTSVTDTSIPCV-----TKQAVGRSRREAVFSSGVVQVTFDGFRPLSPPGEFSFTADPFVDDISPKKTFPGGGLRMTVRGKYFESVQNPKMYYTIAGMDGARSEVEECVKVSNTEMICPSP---NVTEF---NVMPGSMNGSELIVGFIMDQVPGLENETTLAITENPFFLPFANGERELKEANLIIEGKNLDILS-----KDDVFVTVGGVPCNLTGLDDTQLVCLVPDKATLPEVNN-EVYE-----------VIVTAGYLKFNIGKVRYFKEKPPPKSYMTYIYIGVAAGGFVLLVVILCLVCAYRRKKRQEKRHVKDFEVRMDNLESKVAKECREAF----AELQTDMTDLKSDLTTSGMPFLDFRTYALNVLFPGVD----------------------------DHSVTHFKDANLSPVWEQGLRKFSQLIYNKEFLLIFVRTVESQKTFSMKDRCNLASLLMVTLQGKMDYATEILWQLLCDLIRKSVAQSHPKLLLRRTESVAEKLLTNWLAFCMYNHLK-VESGEPLFMMFKAIKRQVGKGPVDAVTGEARYSLSEDK---LLRQTIDYEEIRVNVTFEDQPPTMVTVLDCDSVSQAKSKMLDAVYKNVPFSSRVEAETLQLDWHLTDGSVKPLRDDDASSVVEGQWRKLNTLGHYKVTDGANLKLSPRQ--------------SYFYSSSNNSERQHHHRSLPRVVFSP--FNYTPISRGSREDLDEGGRIWHLVKLLDYPTDKD---DTQHSKMLAEIYLTRLLATKGTLQQFVDGLFNSMFNSNCRPPVPVKYLFDLLDSQAKELNLSDSEVLHTWKNNSLPLRFWINIVKNPNFIFDIE--KSGTVDSCLSVIAQLFMDACSISEHRLGIHSPSNKLLYAKEIPAYKQRVEQFYQNITALPSPSGEE 1816
BLAST of plexin A vs. Ensembl Nematostella
Match: EDO29710 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2V4]) HSP 1 Score: 59.3066 bits (142), Expect = 1.666e-9 Identity = 24/75 (32.00%), Postives = 43/75 (57.33%), Query Frame = 2
Query: 1520 LFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQ 1741
L N+ + + ++++++ +YA D K+I+H ++ C + CE C R PFCGWC KC V+ +C + P +
Sbjct: 19 LPGNVIWKLDLSKDRTAVYATTDFKVIKHPIQECSTFSTCESCSGRGDPFCGWCTLYNKCSVRSECADSSLSPLR 93
BLAST of plexin A vs. Ensembl Medaka
Match: plxna2 (plexin-A2 [Source:NCBI gene;Acc:101158766]) HSP 1 Score: 261.536 bits (667), Expect = 1.479e-69 Identity = 364/1695 (21.47%), Postives = 701/1695 (41.36%), Query Frame = 2
Query: 797 NYIFFLVNQPE-------NKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNF--VDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCL----ETCDNSTAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDD---SKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQF-------KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFTD-VQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKLVT-INLEVNDQISVSAFH-QSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQ----SKQRLRHEKENIFTEKII--KEANEVLKRGIAELNQAAIQDEIHKNWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIEN---TVEYSRKL-SKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGY-------TLKTLKDYDIKDGDNICVAMKNES---LPASNTASVSHLESNSASLK-TNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNICK-----DDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
N+++FL QPE + + + R+VR+C D + S++ + + C + N Y + + + +A S + D +LF F + + C + I EI C G G++ N D C ++D F G + N+ + G + GH + + + S++ + +Y + +A +G G L K + +E + + +++F++ ++S +Y +++ ++ + + +C C +CL P CGWC+ + C K +C A P++ ++ C V P + S S ++ +VS P + + C F + + V+ ++ + + C+ P K++P I ++++ VDL+L L+ YNC+ + C CVN+ F C WC N C C N DCP L S E L VG I L KN + + + C+ TA+ S+S + + + + ++ + + V W GN + I+ I+ ++ C + C C+ + ++CG+C+ + +C +H C + ++W+N S+ KC P I E+ P + + + G NLG +D+++ + + C +E YI ++Q C++ P Q + T+ +L + F +P V + P+ GP GGT + + G L GS V+F T C I C + S +Q+++ + + + + FE+ +P V +I + +++G +TG NL+ + +P + + SI +N S + C +P+ Q ++ A E G + ++ +++ L PN P + +++QK + I L+ + + +A + ++ + +G C+ ++ + + C ++ +Y++ + +G LTVS D L +++ I +++ I+ILV++ +K + + +RL+ + +N+ + + KEA L+ I EL + I P Y Y++ LFP HP++ ++++V N +VE + KL +L +++F+L F LE + + + ++ S + L L T +LK L+ + D+ + N + + R + K+L+NWF L++ L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS ++ D R+ + E + L TL Y + D + + K S +P+S + S + + +S + T ++ PM + PD+ + + L + HE+ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS ++++
Sbjct: 314 NFVYFLTVQPEIPENSMSSSGSNNDLFYTSRIVRLCKDDRKFHSYVSLPIGC-VKNGVEYRLLQAAYLGKPGRILA---------SSLGISAQDD---VLFTVFS--KGQKQFHRPPDDSALCVFTIREINARIKERLQSCYQGEGNLELN--WLLGKDVHCTKAPVPIDDSFC--------GLDINQPLGGSQL----VTGHTLFTETRDRMTSVVSY-VYNGYCVAFVGTKSGRLKKIRVDGPPHGGAQYETVPVIKDGSPVLRDMAFSL----DRSFLYVMSERQVTQVPIESCEQYETCGECLSSGDPHCGWCVLHNMCSQKSRCERADE-PYRFAASLNQCVKAAVYPDS--IAVSEPSVPLLVKVSDVP-----DLSAGITCSFGN-----LTEVEGQ--VNGNQILCVSPAAKDVPLIPTDQDWSGVDLRLNSKETGQMLISTEIKFYNCSVHQLCLSCVNSAFLCHWCKYRNLCTHDP-SSCSFQEGRVNTSEDCPQLVPSEEIL-IPVGEVKPITLKAKNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMKISELPVEFSVVWN-GNFI---IDNPENIKVHLYKCAAQRDSCGLCLKADRKFQCGWCSEEGRCTLRHHCPAINPYTTRWLNLSSRNVKCTNPRITEVTPVAGPPEGGTRVTIYGTNLGLSFSDMEDNVQVAGVQ----CTPVEDGYIIAEQIVCEMAAAPAS-SRPGPVQLCVGECKPELSTRSSHL----YSFVTPTVTGLSPSRGPESGGTKVTIMGENLGAGSTVNVQFGNQT----CEFFRRTTTEIVC-------------YSAPSLFGIGPVQISVRVDHARIRESLPFEYIEDPTVLRIEPDWSIASGNTPLMVTGTNLDVVQEPRIRVKYAGRESINVCKVLNTSTLSCFAPSLMVEYQPGLDTVKHADEFGFIFNNIQALLVYNNTNLLYYPNPYFEPLSNTGVLEQKPGSPIILKGRNLVPPAAGGVKLNYTVLIGETPCS-VTVSESQLLC-----EPPNLTGQYKVVVQVGG--LTVSPGAVHIMSDSLLTLPAIVSIAAGGGLLLIIVILVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGI-------PHLDYRTYVMRVLFPGIE----------------------------DHPVL--RELEVSGNGQQSVEKALKLFGQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDRNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIAVKVLNCDTITQVKEKILDAVYKNMPYSQRPR-------AVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLLHYQVSDRSVVALVPKQTSSYNIPSSASISRTSISRYDSSFRYTGSPDSLRSRAPMIT--PDLESGVKVWHLVKN-HEHGDQKEGDRGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVHRGSTLPLAIKYMFDFLDEQADKHAIYDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHR 1856
BLAST of plexin A vs. Ensembl Medaka
Match: PLXNA2 (plexin-A2 [Source:NCBI gene;Acc:101160644]) HSP 1 Score: 259.61 bits (662), Expect = 5.199e-69 Identity = 378/1784 (21.19%), Postives = 731/1784 (40.98%), Query Frame = 2
Query: 797 NYIFFLVNQPENKHEPKNGL----------FQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRC------MEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYKYEL---------FEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVS-PFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKNFVDLKLKVLINDSHLVEGIYHI--YNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNS----TAIGSLSASNRLVCTFQMMKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHIC---GNDDSKWIN--SKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIND-RIETPVAFQF-KFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKDKLIRFKRSSNPKKASLQLNIDANSIQFT-DVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKGSVCVYNTSITIFSTPVLRINPNKISLPTNLLRIIKQKL-VTINLEVNDQI-SVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVSGYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIA-ELNQAAIQ-----DEIHKNWNTA--PIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYS----------NWSSFESYCLIKLNQDEVPESERLLAPIALK-EVVGYTLKTLKDYDIKDGDNICVAMKNES---LPASNT--ASVSH------LESNSASLKTNKSRNISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSK------IKCCYKTKISAFKDGHHLKPACLIYTQVLKSKIEGQIKNLFDDIFDYESVPLCVSDLFTHFNNIC-----KDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQN---KDVWLTQ-LFSDVIKLYSPKVLNYYEGIKGTGSF---NYNEYYG-SSRIDG--INISLAIVILYQNYINSVHKELVEVIQ 5860
++++F+ QPE P+NG+ + R++R+C D + S++ + + C I Y + + ++ V +A K+ S +LF F Y + + C + I +I C G G N + D +C ++D F CG I G + ++ R + + + IY ++ +G G + K L +E + T ++ +++F++ ++S +Y ++ +++++ + +C C +CL P CGWC+ + C +D+C M F+ + C + VI + S S ++ +V+ P + + C F +A + + + C+ P GK +P I E +++ ++L++ ++ + + YNC+ + C CVN+ F C WC N C C N DCP L S E L G I L +N + + + C+ + TA+ S S + + M + ++ + + + + W GN + I+ I+ ++ C + C C+ + ++CG+C+ + +C K C S+W++ S+ KC P I E+ P + +++ +KG NLG ++++ + + C E+ YI+++Q C++ D + PV + K + + L ++ + F SP + ++ P GP GGT + + G L+ GS + F T C + + I C F S +Q+++ + + + FE+ +P V++I +++G + +TG NL+ + +P V + S+ +N + I C +P+ + S+ E G V ++ F+ PN P +L +++QK I L+ + + S S + ++ + +G C+ ++ + C E + HK +L G + G++ + + S++ + I + +L++V+I+ + + R EN T K ++ + L+ +A E +A + +E+ + + A P Y + + LFP + P L V Q N + ++ ++L +++F+L F LE + + + + S + L L T ILK L+ + ++ + N + + R + K+L+NWF L++ L+ AG L +L+ I + GP++ T +++Y+L+E+ L+ ++IE+K L L + EN E+ V+VL+CD I+Q K KI + +YK PYS W + ++ ++D I K E L TL Y + + + + K S +P+S + SVS S S + SR +PM PD+ + + L + H++ QK + Y T++ A K L+ ++ + LF + ++PL + +F + D + KSN L LRFW+ +I N F+FD+ K + CL V++ MD CS +++ KD T+ L++ I Y V YY I + + N Y +R+ N+ A+ +Y Y++ +E++E ++
Sbjct: 261 SFVYFMTVQPET---PENGMSGGGSPGDLFYTSRIIRLCKDDKKFHSYVSLPVGC-IHRGEEYRLLQAAYLSKVGRVLA------------KSLNISAQEDVLFAVFS--KGQKQYHDPSDHSALCIFTIQDINARIKERLQSCYQGEG--NLELHWLLGKDVQCTKAPVPIDDHF-------CG------LDINQPLGGSQLVSGRTVFTESRDRLTSVTSYIYNGHSVVFLGSRSGRIKKIRLDNALEGGVLYETVIVMKDTGSILRDMAFSL----DRSSLYVMSKNQVVQVPVESCEQYGTCAECLSSGDPHCGWCVLHNMCSRRDRCPR-MDESFRFATDIDRC--VKVISHPDSIAVSAHSVPLLLEVNNVP-----DLSAGITCSFGQQT-------QADGHVKGNRVMCLSPAGKEVPRIPEGQDWAGVELRLNSKETGQMVASTEVKFYNCSTHQMCLSCVNSTFRCHWCKYRNLCTHDP-SSCSFQEGRVNGSEDCPQLLNSGEIL-IPAGEVRPITLRARNLPQPQSGQRGYECVVNVQGASHRVTALRFNSTSVQCQNSSYMYESVKISDLAVDLSIIWN-GNFI---IDNPEKIKVHLYKCSAQRDSCGMCLRAEKKFQCGWCSGEGRCTMKQHCPPISPYASRWLDLSSRNVKCTNPRITEVSPVAGPVEGGTLVTIKGLNLGLSFSELEGNVEVAGVQ----CTPKEEGYITAEQIVCEMTVAPDGSVPGPVKLCIDECKPELQALSTQLYSFVSPTMVALIPGRGPESGGTKVTIVGESLDAGSNINILFGNQT----CELFKRTNLEIVC-------------FSGPSVTGAGPVQVSLTVDRARVPGSLSFEYIEDPTVQRIEPLWSITSGHTILTVTGTNLDVVQEPRVRVKYAGQESVNVCKVLNTTTISCFAPSLKADYTNDQESIKHVDEFGFVFNNVQALLTFNNTGFIYYPNPYLEPLSLTGVLEQKPGAPIILKGRNLVPSASGGARLNYSVLIGDAPCS-LTVSDTQLLC---EPPNLTGQHK----------ILVQVGGLHISPGEVHIRSDSLLTLPAISSITAGGGLLLIVVIIVLLAYR---RKSHENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGIPFLDYRTFAMRVLFPGID------------------------DHPVLRELEVPGSGQA--NVEKALKQFAQLVNNKVFLLTFIRTLELQRSFSMRDRGYVASLIMTALQSRLEYATDILKHLLSDLIERNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKEC-AGEPLFMLFCAIKQQMEKGPIDAVTGEARYSLSEDKLIRQQIEYKTLTLSCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSLRPRAADMDLEWRQGRTARVVLQDED-----------ITTKIEGDWKRLNTLMHYQVSERCVVALVPKQMSSFIIPSSASFPRSVSRYGVDVPFRSTPTSPDSPHSR-----VPM--LTPDLESGVKVWHLVKN-HDHGDQKEGERGSKMVSEIYLTRLLATKG-------------TLQKFVDDLFETLFSTVCRGTALPLAIKYMFDFLDEQADRHGIHDVDVRHTWKSNCLPLRFWVNVIKNPQFVFDIH--KSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSTKLLYAKDIPHYKSWVERYYADINRLPAISDQDMNAYLAEQARLHSSEFNVLSALHEIY-TYVSKYSQEIIEALE 1886
BLAST of plexin A vs. Ensembl Medaka
Match: ENSORLT00000020869.2 (plexin-A1 [Source:NCBI gene;Acc:101175150]) HSP 1 Score: 254.988 bits (650), Expect = 1.236e-67 Identity = 345/1525 (22.62%), Postives = 640/1525 (41.97%), Query Frame = 2
Query: 1304 GKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYK-----------YELFEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKN---FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQK------ASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN----DRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKD-KLIRFKRSSNPKKASLQLNIDANSIQF--TDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKG-------SVCVYNTSITIFSTPVLR-INP-NKISL-PTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVS-GYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFN-----NICKDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
G++FN+ + G S I + + G + + Y T+A +G +G L K L+E L ++ F+ + IY + D +++R + +C T C +CL P CGWC+ + C KD+C A P + + C + V P + + S ++ Q P LSE + C F V+ I + C+ P +I PI +NK + L LK D + YNC+ ++C CVN F C WC + C ++ C + N CP + S + + VG I L KN + + ++ C+ T S+ A + Q K + + + V W G + P I+ ++ C L + C C+ ++CG+C + KC + C ++ W+++ +C P I ++ P +++ + G NLG D++N + + + C E+ YIS+++ C++ + + V + K + +K F F +P + PN GP GGT I + GS LN GS V N G P CR FE ++ K I S+ ++ + +D NS + +V+F + +P + KI + +++GG +TG + + +P + + LS+ +NN+ + C+ P+ + Q +++ E G SV V N + + PVL ++P K+ L PT+ L + + L+ + V+ ++ ++ + +G C ++ + + C + L G++ +TV G ++ G + + + S++ + I+ + +L++VII+ + K++ R + +++ + + + R E + A +Q +IH+ + P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK +PYS K + ++ + +A I L++ T L TL Y + DG I V +N + SN+++++ L + L+T S + + PM PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 404 GQDFNQPL-----GGTSPIEGVPLYIDKEDGMTSVAAYDYRGNTVAFVGTRNGKLKKILVNSVNSNRSAVLYEKVTVSEGGSPLLRDMLFSPDLQH----IYTLTDRQVVRVPVESCEQYTTCGECLGSRDPHCGWCVLHNVCSRKDRCERA-GEPQRFASDQRQCVELTVQPGNISVTMSEVQ--LVLQARNVP--DLSEG---VNCSFEDY-------VETEGRIQGEHIFCLSPSATDIAPITKNKGDKRVIKLYLKSKETDKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKFRHICTQNAY-DCSFMEGLIKNSEGCPQILPSTQ-IYIPVGVTKPIHLAAKNLPQPQSGQRNYECVFHIQGETH--SVPAVRFNSTSIQCQKTAYNYEGDDISDLPVDLSVMW------NGKFVIDNPLNIKAHLYKCDALRKSCGMCLKANPRFECGWCAAEKKCSLRQECTPPETTWMHATTGNTRCIHPKITKLTPDLGPRQGGTMLTILGENLGLQFKDIQNGVRIG----KVICIPQEEEYISAERIVCQLNDATGYRVQHAQVEVCVRDCLHPDYKTVSAKPFTFVTPFFTHVHPNVGPQSGGTRITIEGSDLNAGS--NVTVNIGLYP--------------CR---FEKRNSKEIVCVTSAAKATGAMPVMVDINSAELRNPEVKFNYTSDPTILKIDPDWSIASGGTTLTVTGTDFATIKEPRMRAKYGAALSVNNCTVLNNTVMVCLVPSVAGSDQLLPDAVISPDEIGFVMDDVHSVLVVNETFSYHPDPVLEPLSPTGKLVLKPTSPLILKGRNLIPV---------VTGNYKLNYTVLIGDTPCV-LTLSESQLLC--------------EWPNLTGEHKVTVRVGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIMVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVPANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAMTGEARYSLSEDKLIRQQIDYKTLTLHCVNPENENAPEVTVKSLNCDTVTQVKEKLLDAVYKGTPYSQRP--------KASDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVMDGSVIALVPKQNSAYNISNSSTLTKSLSRYESMLRTASSPDSLRSRTPM--LTPDLESGTKLWHLVKN-HDHSDQREVDRGS--------------KMVSEIYLTRLLSTK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHFITDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1785
BLAST of plexin A vs. Ensembl Medaka
Match: ENSORLT00000035326.1 (plexin-A1 [Source:NCBI gene;Acc:101175150]) HSP 1 Score: 253.832 bits (647), Expect = 2.968e-67 Identity = 328/1435 (22.86%), Postives = 611/1435 (42.58%), Query Frame = 2
Query: 1541 NMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKN---FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQK------ASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN----DRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKD-KLIRFKRSSNPKKASLQLNIDANSIQF--TDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKG-------SVCVYNTSITIFSTPVLR-INP-NKISL-PTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVS-GYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFN-----NICKDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
+M+ + + IY + D +++R + +C T C +CL P CGWC+ + C KD+C A P + + C + V P + + S ++ Q P LSE + C F V+ I + C+ P +I PI +NK + L LK D + YNC+ ++C CVN F C WC + C ++ C + N CP + S + + VG I L KN + + ++ C+ T S+ A + Q K + + + V W G + P I+ ++ C L + C C+ ++CG+C + KC + C ++ W+++ +C P I ++ P +++ + G NLG D++N + + + C E+ YIS+++ C++ + + V + K + +K F F +P + PN GP GGT I + GS LN GS V N G P CR FE ++ K I S+ ++ + +D NS + +V+F + +P + KI + +++GG +TG + + +P + + LS+ +NN+ + C+ P+ + Q +++ E G SV V N + + PVL ++P K+ L PT+ L + + L+ + V+ ++ ++ + +G C ++ + + C + L G++ +TV G ++ G + + + S++ + I+ + +L++VII+ + K++ R + +++ + + + R E + A +Q +IH+ + P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK +PYS K + ++ + +A I L++ T L TL Y + DG I V +N + SN+++++ L + L+T S + + PM PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 424 DMLFSPDLQHIYTLTDRQVVRVPVESCEQYTTCGECLGSRDPHCGWCVLHNVCSRKDRCERA-GEPQRFASDQRQCVELTVQPGNISVTMSEVQ--LVLQARNVP--DLSEG---VNCSFEDY-------VETEGRIQGEHIFCLSPSATDIAPITKNKGDKRVIKLYLKSKETDKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKFRHICTQNAY-DCSFMEGLIKNSEGCPQILPSTQ-IYIPVGVTKPIHLAAKNLPQPQSGQRNYECVFHIQGETH--SVPAVRFNSTSIQCQKTAYNYEGDDISDLPVDLSVMW------NGKFVIDNPLNIKAHLYKCDALRKSCGMCLKANPRFECGWCAAEKKCSLRQECTPPETTWMHATTGNTRCIHPKITKLTPDLGPRQGGTMLTILGENLGLQFKDIQNGVRIG----KVICIPQEEEYISAERIVCQLNDATGYRVQHAQVEVCVRDCLHPDYKTVSAKPFTFVTPFFTHVHPNVGPQSGGTRITIEGSDLNAGS--NVTVNIGLYP--------------CR---FEKRNSKEIVCVTSAAKATGAMPVMVDINSAELRNPEVKFNYTSDPTILKIDPDWSIASGGTTLTVTGTDFATIKEPRMRAKYGAALSVNNCTVLNNTVMVCLVPSVAGSDQLLPDAVISPDEIGFVMDDVHSVLVVNETFSYHPDPVLEPLSPTGKLVLKPTSPLILKGRNLIPV---------VTGNYKLNYTVLIGDTPCV-LTLSESQLLC--------------EWPNLTGEHKVTVRVGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIMVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVPANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAMTGEARYSLSEDKLIRQQIDYKTLTLHCVNPENENAPEVTVKSLNCDTVTQVKEKLLDAVYKGTPYSQRP--------KASDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVMDGSVIALVPKQNSAYNISNSSTLTKSLSRYESMLRTASSPDSLRSRTPM--LTPDLESGTKLWHLVKN-HDHSDQREVDRGS--------------KMVSEIYLTRLLSTK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHFITDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1724
BLAST of plexin A vs. Ensembl Medaka
Match: ENSORLT00000040208.1 (plexin-A1 [Source:NCBI gene;Acc:101175150]) HSP 1 Score: 253.832 bits (647), Expect = 3.429e-67 Identity = 345/1525 (22.62%), Postives = 640/1525 (41.97%), Query Frame = 2
Query: 1304 GKNFNKFIIGDHYGENSIIGHRVISRNGVQGYSLIVFSIYEKFTLAMIGGNDGILYK-----------YELFEDTNYLFSTENLFNNISFNMVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCL-RVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKACPLINVIPSHSILEYSNKSPTVIFQVSKTPLSILSENDKFLKCKFTSNNNREIANVKAHYFIHNHSLSCIGPHGKNIPPIAENKN---FVDLKLKVLINDSHLVEGIYHIYNCAHSRTCAHCVNNKFNCSWCVLDNSCISSSLGKCKKNFEIQNNQPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMMKVLQK------ASIKCSMKVSWILGNLLTGSIETETP--IEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKF--QKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNIN----DRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILENQENYISCRLNDFEVKD-KLIRFKRSSNPKKASLQLNIDANSIQF--TDVQFEFFPNPHVKKISKNKFLSNGGQMFKITGDNLNRLNKPSVAFRCETFLSIYENCFVNNSDIDCISPTTSNITQFQKCSLLFAMEKG-------SVCVYNTSITIFSTPVLR-INP-NKISL-PTNLLRIIKQKLVTINLEVNDQISVSAFHQSDFKIFVGPIICTNISFFGNNIRCNIIEVNQIDIYHKYQISLLMGKNVLTVS-GYIQFEKGDISLDNMSXXXXXXXXXXXXXXXXXXXXXXXKKVQSKQRLRHEKENIFTEKIIKEANEVLKRGIAELNQ--AAIQDEIHK-----NWNTAPIHQYIVYILYNLFPNTHPRLYXXXXXXXXXXXXXXYYKYNCNDPFTHPLIVNKQIQVIENTVEYSRKLSKLFEDELFVLMFFSFLEDHQEVESK-KSDIVSFLSLILMKDLPNYTRILKILIKNDYDK--KKLNEEERSMFRQSDLLSKLLSNWFFILMYDHLQNINAGGDXXXXXXXXXXXXXXGPVNWETSKSQYALNENSXXXXXXXXXXXXXXXXXXXXXNDSELVVEVLDCDCISQAKLKIFEEIYKYSPYSNWSSFESYCLIKLNQDEVPESERLLAPIALKEVVGYT--------LKTLKDYDIKDGDNIC-VAMKNESLPASNTASVSH-LESNSASLKTNKSRN-ISKDIPMTSFLPDISKRIPIHRLSDSLHENSSQKSKIKCCYKTKISAFKDGHHLKPACLIY-TQVLKSKIEGQIKNLFDDIFDY--------ESVPLCVSDLFTHFN-----NICKDDSIVFAVKSNSLVLRFWIQLINNIDFLFDVPLVKHTPVLECLKCVSRILMDICSENQNK 5644
G++FN+ + G S I + + G + + Y T+A +G +G L K L+E L ++ F+ + IY + D +++R + +C T C +CL P CGWC+ + C KD+C A P + + C + V P + + S ++ Q P LSE + C F V+ I + C+ P +I PI +NK + L LK D + YNC+ ++C CVN F C WC + C ++ C + N CP + S + + VG I L KN + + ++ C+ T S+ A + Q K + + + V W G + P I+ ++ C L + C C+ ++CG+C + KC + C ++ W+++ +C P I ++ P +++ + G NLG D++N + + + C E+ YIS+++ C++ + + V + K + +K F F +P + PN GP GGT I + GS LN GS V N G P CR FE ++ K I S+ ++ + +D NS + +V+F + +P + KI + +++GG +TG + + +P + + LS+ +NN+ + C+ P+ + Q +++ E G SV V N + + PVL ++P K+ L PT+ L + + L+ + V+ ++ ++ + +G C ++ + + C + L G++ +TV G ++ G + + + S++ + I+ + +L++VII+ + K++ R + +++ + + + R E + A +Q +IH+ + P Y Y + LFP HP++ K+++V N + +L + F+L F LE + + + ++ S + L ++ T +LK L+ + DK + N + + R + K+L+NWF L+Y L+ AG L +LY I + GP++ T +++Y+L+E+ L+ ++I++K L L + EN E+ V+ L+CD ++Q K K+ + +YK +PYS K + ++ + +A I L++ T L TL Y + DG I V +N + SN+++++ L + L+T S + + PM PD+ + L + H++S Q+ + K IY T++L +K G ++ DD+F+ ++PL + +F + + D + KSN L LRFW+ +I N F+FD+ K++ CL V++ MD CS +++K
Sbjct: 404 GQDFNQPL-----GGTSPIEGVPLYIDKEDGMTSVAAYDYRGNTVAFVGTRNGKLKKILVNSVNSNRSAVLYEKVTVSEGGSPLLRDMLFSPDLQH----IYTLTDRQVVRVPVESCEQYTTCGECLGSRDPHCGWCVLHNVCSRKDRCERA-GEPQRFASDQRQCVELTVQPGNISVTMSEVQ--LVLQARNVP--DLSEG---VNCSFEDY-------VETEGRIQGEHIFCLSPSATDIAPITKNKGDKRVIKLYLKSKETDKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKFRHICTQNAY-DCSFMEGLIKNSEGCPQILPSTQ-IYIPVGVTKPIHLAAKNLPQPQSGQRNYECVFHIQGETH--SVPAVRFNSTSIQCQKTAYNYEGDDISDLPVDLSVMW------NGKFVIDNPLNIKAHLYKCDALRKSCGMCLKANPRFECGWCAAEKKCSLRQECTPPETTWMHATTGNTRCIHPKITKLTPDLGPRQGGTMLTILGENLGLQFKDIQNGVRIG----KVICIPQEEEYISAERIVCQLNDATGYRVQHAQVEVCVRDCLHPDYKTVSAKPFTFVTPFFTHVHPNVGPQSGGTRITIEGSDLNAGS--NVTVNIGLYP--------------CR---FEKRNSKEIVCVTSAAKATGAMPVMVDINSAELRNPEVKFNYTSDPTILKIDPDWSIASGGTTLTVTGTDFATIKEPRMRAKYGAALSVNNCTVLNNTVMVCLVPSVAGSDQLLPDAVISPDEIGFVMDDVHSVLVVNETFSYHPDPVLEPLSPTGKLVLKPTSPLILKGRNLIPV---------VTGNYKLNYTVLIGDTPCV-LTLSESQLLC--------------EWPNLTGEHKVTVRVGGFEYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLVIIMVLIAYKRKSRDADRTL--KRLQLQMDNLESRVALECKEAFAELQTDIHELTQELDGAGIPFLDYRTYAMRVLFPGIE----------------------------DHPVL--KEMEVPANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKEC-AGEPLFMLYCAIKQQMEKGPIDAMTGEARYSLSEDKLIRQQIDYKTLTLHCVNPENENAPEVTVKSLNCDTVTQVKEKLLDAVYKGTPYSQRP--------KASDMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVMDGSVIALVPKQNSAYNISNSSTLTKSLSRYESMLRTASSPDSLRSRTPM--LTPDLESGTKLWHLVKN-HDHSDQREVDRGS--------------KMVSEIYLTRLLSTK--GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHFITDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDI--HKNSITDACLSVVAQTFMDSCSTSEHK 1785
BLAST of plexin A vs. Planmine SMEST
Match: SMESG000006542.1 (SMESG000006542.1) HSP 1 Score: 838.951 bits (2166), Expect = 0.000e+0 Identity = 409/434 (94.24%), Postives = 413/434 (95.16%), Query Frame = 2
Query: 62 MIKTKRFLILSVINIFITEICALTSEIFVYKYENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKAYSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFTSTGKGECGGKNFNKFIIGDHYGENSIIG 1363
MIKTKRFLILSVINIFITEICALTSEIFVYKYENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEP QCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNK YSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFT + +C + + H G IG
Sbjct: 1 MIKTKRFLILSVINIFITEICALTSEIFVYKYENLDKIMLHNNKSHKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPYQCQTSLCPKELISRDQCRIKLTDVFVKLWTFADSYLVVCYDVFQGFCEIIDLYNQFSSSYKNKVYSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYFKPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNCDIDNQWTYYQVHSWIVANVSDDMANWYRNKTRFSRIKTEMDSDFHQILFINFKIILVTNNYRETFNSFVTCAYPIAEIMELYDVVRNLCLVGSGSVNENPYNFKSTDKRCMEDGFT---QPDCPTLEVSNETLSFHVGSPISIG 431 HSP 2 Score: 140.969 bits (354), Expect = 1.147e-34 Identity = 67/69 (97.10%), Postives = 68/69 (98.55%), Query Frame = 2
Query: 2219 QPDCPTLEVSNETLSFHVGFPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMM 2425
QPDCPTLEVSNETLSFHVG PISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQM+
Sbjct: 407 QPDCPTLEVSNETLSFHVGSPISIGLMTKNFRNYFNSKTDFVCLETCDNSTAIGSLSASNRLVCTFQMV 475
BLAST of plexin A vs. Planmine SMEST
Match: SMESG000006541.1 (SMESG000006541.1) HSP 1 Score: 488.804 bits (1257), Expect = 2.066e-159 Identity = 238/238 (100.00%), Postives = 238/238 (100.00%), Query Frame = 2
Query: 2423 MKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE 3136
MKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE
Sbjct: 1 MKVLQKASIKCSMKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE 238
BLAST of plexin A vs. Planmine SMEST
Match: SMESG000006541.1 (SMESG000006541.1) HSP 1 Score: 465.307 bits (1196), Expect = 5.071e-151 Identity = 226/226 (100.00%), Postives = 226/226 (100.00%), Query Frame = 2
Query: 2459 MKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE 3136
MKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE
Sbjct: 1 MKVSWILGNLLTGSIETETPIEFQVFDCLKLSEHCDDCVHLPQIYKCGFCTVKDKCVQKHICGNDDSKWINSKFQKCPLPSIMEIIPSNSTLSSESVILVKGRNLGFYENDVKNAITLENNHFQFFCKYIEQSYISSKQFKCKIQNINDRIETPVAFQFKFKTKDKYLVSKEFKFFSPRVYSIEPNFGPFIGGTIIKVNGSFLNIGSRREVKFNYGTAPIICNILE 226
BLAST of plexin A vs. Planmine SMEST
Match: SMESG000049328.1 (SMESG000049328.1) HSP 1 Score: 157.147 bits (396), Expect = 7.577e-45 Identity = 73/73 (100.00%), Postives = 73/73 (100.00%), Query Frame = 2
Query: 1544 MVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKA 1762
MVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKA
Sbjct: 1 MVVNENKSVIYAVADSKIIRHNLRNCYNGTNCEDCLRVSPFCGWCISNGKCVVKDQCTTAMWLPFQRNRTVKA 73
BLAST of plexin A vs. Planmine SMEST
Match: SMESG000070796.1 (SMESG000070796.1) HSP 1 Score: 75.0998 bits (183), Expect = 1.629e-13 Identity = 71/256 (27.73%), Postives = 115/256 (44.92%), Query Frame = 2
Query: 197 HKSILVSGKNYILQFSENNLKEPLAIRKTGPVNHSVMCTEPNQCQTSLCPKELISRDQCRIKLTDVFVKLWTFA--DSYLVVCYDVFQGFCE--IIDLYNQFSS--SYKNKAYSIVTNDRKFHSTVLYHDQRLFFANEVYHPSNYREIDFNTMSILSFPNMTYF-----KPDYPFQANFGKLVYQGGETIFPLEFVGSFHIYDSRKDAFFKNYIFFLVNQPENKHEPKNGLFQVRLVRICSFDDDYTSFIDIGMNC 931
HK I+V+ KN+I+ S++ + L TGPVN S+ C +C + CP C TDV VK W YL+VCY+++QG+CE +ID + S +V D + ST+ D L ++ +Y + N + ++SF N+ F KP + N L + F L+F F +AF I L +QP + ++ + + R+C D D+ S+++I + C
Sbjct: 41 HKRIIVAIKNFII-VSDSFTYQILNTITTGPVNDSLYCINSMECDPN-CPSS------CGKVSTDVSVKSWIVDRNQQYLIVCYNIYQGYCERFLIDTDGNINPNRSIDKTTTPVVNADPRGASTLFVFDNILIVCSQ--RNISYDPLKLN-LPVISFRNIDDFHIIQPKPFQLLRENLSGLQLKTTSE-FSLKFHKVFEFTTRTSEAF----ILILFSQPRKLKDSRSSDNCIVMSRMCKEDYDFESYVEIQLQC 280 The following BLAST results are available for this feature:
BLAST of plexin A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of plexin A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of plexin A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of plexin A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of plexin A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of plexin A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of plexin A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of plexin A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of plexin A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014347 ID=SMED30014347|Name=plexin A|organism=Schmidtea mediterranea sexual|type=transcript|length=6045bpback to top protein sequence of SMED30014347-orf-1 >SMED30014347-orf-1 ID=SMED30014347-orf-1|Name=SMED30014347-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1976bp MIKTKRFLILSVINIFITEICALTSEIFVYKYENLDKIMLHNNKSHKSILback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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