Multidrug resistance-associated protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014286 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9Note: Hover over icons to view figure legend
Homology
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 822.387 bits (2123), Expect = 0.000e+0 Identity = 505/1339 (37.71%), Postives = 778/1339 (58.10%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR---------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ I + +++ ++ + LN +TS + ++C K K+ ++ P S++ E+ + LI K +E+ S + K L + + P + K D+++ + P +LKLL+ ++ + W+G +L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++P+N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ + FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D +N + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP-QKEWNPS---LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP-DWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 822.387 bits (2123), Expect = 0.000e+0 Identity = 505/1339 (37.71%), Postives = 778/1339 (58.10%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR---------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ I + +++ ++ + LN +TS + ++C K K+ ++ P S++ E+ + LI K +E+ S + K L + + P + K D+++ + P +LKLL+ ++ + W+G +L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++P+N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ + FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D +N + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP-QKEWNPS---LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP-DWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 817.765 bits (2111), Expect = 0.000e+0 Identity = 505/1349 (37.44%), Postives = 778/1349 (57.67%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR---------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-------------NESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ I + +++ ++ + LN +TS + ++C K K+ ++ P S++ E+ + LI K +E+ S + K L + + P + K D+++ + P +LKLL+ ++ + W+G +L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++P+N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ + FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL S +D+ + + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 108 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP-QKEWNPS---LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP-DWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1435
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 817.765 bits (2111), Expect = 0.000e+0 Identity = 505/1349 (37.44%), Postives = 778/1349 (57.67%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR---------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-------------NESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ I + +++ ++ + LN +TS + ++C K K+ ++ P S++ E+ + LI K +E+ S + K L + + P + K D+++ + P +LKLL+ ++ + W+G +L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++P+N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ + FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL S +D+ + + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 108 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP-QKEWNPS---LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP-DWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1435
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC3 (ATP binding cassette subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:54]) HSP 1 Score: 813.142 bits (2099), Expect = 0.000e+0 Identity = 478/1193 (40.07%), Postives = 722/1193 (60.52%), Query Frame = 2
Query: 452 TWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-NESSDK--------------VDKNQNNLIQPSAPNK------------------RKRSRLSTSG-SQG-------FDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQ---AFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
+W G L+A L F + SL + + V+ R + G+IY+K L ++ + + G+IVN+ SVD ++ M+ + + S P QIILAI L+ LG S+ AGV + +IPLN + R F +++ KD R+ +++EI +G+K++K+YAWE F K++E IR E++ +R + + W PF V IT ++Y PN+++ EK FVS+ LFN L+LP+ +LP +S A VS RI+ FL S++E D + + +SPG I I +G+F+W +D PTL+++++ V L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L K+ N Y + L+AC L D+E LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D+DI+LLDDPLSAVD +V + +F+ +I +G+L KTRVLVTHG+ +LP D I V+ D GQ+SE G Y L+ F +FL N + D+ + + LI+ + N R+ S LS+ G QG +E + K ++ EE+ G V L S+ W Y KA G+ + LA + V Q A G NVWL + N++ + +N+ + Y +G+ Q V+L GG++A++ +H LL +RS FF+ TPSGRILN F+KD++++D L I ++N I++LVVI TP F +V +P+ + Y L+Q FY ++SRQ +RL+S + S + +H ET +G+S+IR+ DFE I +D + + +S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SY+LQVT LNW+ R ++ E+N V++ER+++Y+ E+ + E + E W G + N+S++Y L VL++++++++GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + +LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS+I++LDEATA++D ETD + I+ QF + TV+ IAHRL TI+D +++ LD G + EF SP L++ + G F +A+
Sbjct: 346 SWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFL--SQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAD-GQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVEL-SVFWDYAKAVGL----CTTLAICLLYVGQSAAAIGANVWL------SAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSR-PPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGMAR 1522
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 798.505 bits (2061), Expect = 0.000e+0 Identity = 501/1343 (37.30%), Postives = 773/1343 (57.56%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVP-NSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S L+Q+T+ W Y K+ ++ E +DLN + + EN+ IE+ I ++E + I KKN + ++ + + Y + G K+ D+L P +L+ L++++++K+ W G+ +ALL F L S+ + F ++ + +R+ L +Y KTL LS EAR + G IVN+ SVD++++ + T+ +F S P QI+L++ L+ LG S+ AG + +IP N I R ++ FKD+R+ +++EI +GMK++K+Y+WEK K + E+R EI+ ++ +S ++ W PF V +TF ++ + P N+++TP+ FV+L LFN L+ P+ + SQA+ S R++ F A E ++ + + I++ GSF+W E+ R L++I N++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDDPLSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ ID TL +I ++ +I+++ VI TPW GI + + Y ++ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKA------------ENIIPSFIENLIPEVEGYRRKI-KKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYG---GTDSAIKMDGGSFAWGSKEEDR-KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIEAIDQTLPHSIRAMVMTIFNVISTVFVIIWATPWAGIGFLVLGFVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 793.112 bits (2047), Expect = 0.000e+0 Identity = 504/1345 (37.47%), Postives = 774/1345 (57.55%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVP-NSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPW--FGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S L+Q+T+ W Y K+ ++ E +DLN + + EN+ IE+ I ++E + I KKN + ++ + + Y + G K+ D+L P +L+ L++++++K+ W G+ +ALL F L S+ + F ++ + +R+ L +Y KTL LS EAR + G IVN+ SVD++++ + T+ +F S P QI+L++ L+ LG S+ AG + +IP N I R ++ FKD+R+ +++EI +GMK++K+Y+WEK K + E+R EI+ ++ +S ++ W PF V +TF ++ + P N+++TP+ FV+L LFN L+ P+ + SQA+ S R++ F A E ++ + + I++ GSF+W E+ R L++I N++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDDPLSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ ++D L NI D + L+ +V S TP+ F IV I I C+ +L+ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKA------------ENIIPSFIENLIPEVEGYRRKI-KKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYG---GTDSAIKMDGGSFAWGSKEEDR-KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDMDVVDERLPDNIGDFLLTFSELVACVVFTSYATPFAIFPIVLIAI-GCFAILR-FYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 791.956 bits (2044), Expect = 0.000e+0 Identity = 500/1343 (37.23%), Postives = 766/1343 (57.04%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVP-NSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S L+Q+T+ W Y K+ ++ E +DLN + + EN+ IE+ I ++E + I KKN + ++ + + Y + G K+ D+L P +L+ L++++++K+ W G+ +ALL F L S+ + F ++ + +R+ L +Y KTL LS EAR + G IVN+ SVD++++ + T+ +F S P QI+L++ L+ LG S+ AG + +IP N I R ++ FKD+R+ +++EI +GMK++K+Y+WEK K + E+R EI+ ++ +S ++ W PF V +TF ++ + P N+++TP+ FV+L LFN L+ P+ + SQA+ S R++ F A E ++ + + I++ GSF+W E+ R L++I N++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDDPLSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ +ID+ L I + V +T V TP +LI Y L FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKA------------ENIIPSFIENLIPEVEGYRRKI-KKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYG---GTDSAIKMDGGSFAWGSKEEDR-KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIGYYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 788.489 bits (2035), Expect = 0.000e+0 Identity = 497/1343 (37.01%), Postives = 769/1343 (57.26%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVP-NSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S L+Q+T+ W Y K+ ++ E +DLN + + EN+ IE+ I ++E + I KKN + ++ + + Y + G K+ D+L P +L+ L++++++K+ W G+ +ALL F L S+ + F ++ + +R+ L +Y KTL LS EAR + G IVN+ SVD++++ + T+ +F S P QI+L++ L+ LG S+ AG + +IP N I R ++ FKD+R+ +++EI +GMK++K+Y+WEK K + E+R EI+ ++ +S ++ W PF V +TF ++ + P N+++TP+ FV+L LFN L+ P+ + SQA+ S R++ F A E ++ + + I++ GSF+W E+ R L++I N++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDDPLSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ +D + ++ I V I + +I TP + +P+ I Y ++ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKA------------ENIIPSFIENLIPEVEGYRRKI-KKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYG---GTDSAIKMDGGSFAWGSKEEDR-KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-7 (pep chromosome:WBcel235:V:19674843:19693043:1 gene:WBGene00003413.1 transcript:Y43F8C.12.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-7) HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0 Identity = 492/1338 (36.77%), Postives = 762/1338 (56.95%), Query Frame = 2
Query: 32 NPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGW------ILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASE-KENDSNNSMPRKMSPGAPIEIQNGSFSWTED---GRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLM-------DFGTEFKSFLNESSDKVDKNQNNL-----------------------IQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNR---FSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNY-ISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF-KALAQADEYIKHE 3910
+PE SS L+++T W + + + +++ + F+LN + + L L E+ P IHD + KK+ +E+ K VI S+ F + F W LK D + P +L LLN++ K+ + WKG+ +++L F SL N F I ++ +++ +L +YKKTL +S AR + G+IVN+ ++D+E+ F SCP+QI A++ L++ LGYS GV + +P+NII RK+ ++ KD+R ++ E+ +G+K++K+YAWE I+EIR E+ I+ ++ I+ PF V +F F+ P+ L+TP+ FVSL LFN L+ P+ ++ ++QA+ A+VS R++ FL+A E E + S+ + S A + ++N + SW + G TL +++L LIAVVG+VG GKSSLL A+LGEM L G + G++AYVPQ+ WIQN TLR+NI + F++ Y +VL AC L+ DI+ LP DQTEIGE+G+NLSGGQK RVSLARAVYQ+ D+YLLDDPLSAVD +VG+ +F K+I GLL+ KTR+LVTHGL + DEI V+ +G+I E GT+EHL+ DF E+KS + SS+ ++ + + +++ST S + + N + +E I G+V + + Y KA G + + I +++ LQ + WL +D + S ++ + + YG +G + + +F G RASK +H L+ ++RS + F++ TP GRILNR KD+ ID L +N ++ + + +L+VI I TP F +V +P+ + Y++ +Y+ +SRQ +RL+S S + +H ET G++ IR+ +F R +D + + +S RWL +RL+ +GN I+F + +FAVL++ + S ++G+S+SYAL +T +LN+ RQ +E E N VS+ER+ +YT P E+ + W S G + + +S +Y L VL +I+ ++ GEKIG+VGRTGAGKSS ALALFR++E GRI ID V ++ IGLH LR +TI+PQDPV+FSGTL+ NLDPF Y+DD++ ++LE++ + + L +G+ Y G NLS+GQ+QL+ LAR LL+ +++++LDEATA+VD TD + E I+ +F TV IAHRL TI+D D+I+ LD GSI+EF +P L+++ + F K +A A E KHE
Sbjct: 207 SPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNE-----RSGTEFLSELWESFWEPKRLKYIHD----TSIWAKKDPSEQEK--DPVVIPSVVSSLF--MMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFISAKNAPF-WKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIERSHNA-VRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVML-EGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILRSFWLSAWSDEYDPDSPSAHPMAKG---WRLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTNTPNEAPWRIEGREPAPGWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALMADKNSAFAKMVADAAEQDKHE 1525
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090026) HSP 1 Score: 853.973 bits (2205), Expect = 0.000e+0 Identity = 518/1342 (38.60%), Postives = 788/1342 (58.72%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----------GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
E PE +S LS+ITY W DK + ++ ++++ +DL ++ SE + +N+R N +++ +E K G+KN ++ S ++ + + + + FG ++K+F D L P VL L++++++ +D WKGIL A+L F + F + +R+R AL IY+K LR+S + + G+IVN+ +VD ++ M TY + S P QI LA+ L+ +LG S+ AG+ + +IP+N +I + + R++ +KD+R+ ++ E+ G+K++K+YAWE F K++ +IR+ EI +R+ + S LW PF V +TF ++ N+++ K FVSL LFN L+ P+ +LP ++ + VS RI FL + +E D N+ + P P+ I+NG FSW ++ TL NIN+ V+ L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDDPLSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ++ L G + +++ +H+VLL LR ++ F+ TP GRI+NRF+KD+ ID+TL LN+ +I + ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK-NYKNKAR-VEPKAQFSNGNVTFENPHGEKNGRKKGMAS---IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFL--NSEELDPNSVLHDSSKP-HPMSIENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.1073 bits (196), Expect = 1.350e-14 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 2
Query: 2447 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 3907
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090025) HSP 1 Score: 851.662 bits (2199), Expect = 0.000e+0 Identity = 518/1342 (38.60%), Postives = 782/1342 (58.27%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----------GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
E PE +S LS+ITY W DK + ++ ++++ +DL ++ SE + +N+R N +++ +E K G+KN ++ S ++ + + + + FG ++K+F D L P VL L++++++ +D WKGIL A+L F + F + +R+R AL IY+K LR+S + + G+IVN+ +VD ++ M TY + S P QI LA+ L+ +LG S+ AG+ + +IP+N +I + + R++ +KD+R+ ++ E+ G+K++K+YAWE F K++ +IR+ EI +R+ + S LW PF V +TF ++ N+++ K FVSL LFN L+ P+ +LP ++ + VS RI FL + +E D N+ + P P+ I+NG FSW ++ TL NIN+ V+ L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDDPLSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ G L A+K +HS+LL+ VLR+ + F+ TP GRIL+RF+KD+ +D + I D I ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK-NYKNKAR-VEPKAQFSNGNVTFENPHGEKNGRKKGMAS---IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFL--NSEELDPNSVLHDSSKP-HPMSIENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.8777 bits (198), Expect = 8.999e-15 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 2
Query: 2447 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 3907
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090022) HSP 1 Score: 850.892 bits (2197), Expect = 0.000e+0 Identity = 517/1342 (38.52%), Postives = 783/1342 (58.35%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----------GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
E PE +S LS+ITY W DK + ++ ++++ +DL ++ SE + +N+R N +++ +E K G+KN ++ S ++ + + + + FG ++K+F D L P VL L++++++ +D WKGIL A+L F + F + +R+R AL IY+K LR+S + + G+IVN+ +VD ++ M TY + S P QI LA+ L+ +LG S+ AG+ + +IP+N +I + + R++ +KD+R+ ++ E+ G+K++K+YAWE F K++ +IR+ EI +R+ + S LW PF V +TF ++ N+++ K FVSL LFN L+ P+ +LP ++ + VS RI FL + +E D N+ + P P+ I+NG FSW ++ TL NIN+ V+ L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDDPLSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ+ G L+ S+ +H LL LR ++ F+ TP GRI+NRF+KD+ ID+ L NI +I + +++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK-NYKNKAR-VEPKAQFSNGNVTFENPHGEKNGRKKGMAS---IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFL--NSEELDPNSVLHDSSKP-HPMSIENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVATNFFSSLAISLGCLKCSQLLHQTLLYYNLRWPMELFDTTPLGRIVNRFSKDIDTIDNVLPFNIRVVIGQAYMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.4925 bits (197), Expect = 1.189e-14 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 2
Query: 2447 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 3907
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090017) HSP 1 Score: 849.736 bits (2194), Expect = 0.000e+0 Identity = 515/1342 (38.38%), Postives = 786/1342 (58.57%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----------GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
E PE +S LS+ITY W DK + ++ ++++ +DL ++ SE + +N+R N +++ +E K G+KN ++ S ++ + + + + FG ++K+F D L P VL L++++++ +D WKGIL A+L F + F + +R+R AL IY+K LR+S + + G+IVN+ +VD ++ M TY + S P QI LA+ L+ +LG S+ AG+ + +IP+N +I + + R++ +KD+R+ ++ E+ G+K++K+YAWE F K++ +IR+ EI +R+ + S LW PF V +TF ++ + ++ EK+ VS+ LF+ ++LP+ +LP VS RI FL + +E D N+ + P P+ I+NG FSW ++ TL NIN+ V+ L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDDPLSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ++ L G + +++ +H+VLL LR ++ F+ TP GRI+NRF+KD+ ID+TL LN+ +I + ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK-NYKNKAR-VEPKAQFSNGNVTFENPHGEKNGRKKGMAS---IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFL--NSEELDPNSVLHDSSKP-HPMSIENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 84.7297 bits (208), Expect = 4.917e-16 Identity = 120/512 (23.44%), Postives = 225/512 (43.95%), Query Frame = 2
Query: 2447 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVT-GILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 3907
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ + N+ S+ LV +++ +++ IL L+ AE + VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQ---VSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090016) HSP 1 Score: 846.655 bits (2186), Expect = 0.000e+0 Identity = 514/1342 (38.30%), Postives = 781/1342 (58.20%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----------GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
E PE +S LS+ITY W DK + ++ ++++ +DL ++ SE + +N+R N +++ +E K G+KN ++ S ++ + + + + FG ++K+F D L P VL L++++++ +D WKGIL A+L F + F + +R+R AL IY+K LR+S + + G+IVN+ +VD ++ M TY + S P QI LA+ L+ +LG S+ AG+ + +IP+N +I + + R++ +KD+R+ ++ E+ G+K++K+YAWE F K++ +IR+ EI +R+ + S LW PF V +TF ++ + ++ EK+ VS+ LF+ ++LP+ +LP VS RI FL + +E D N+ + P P+ I+NG FSW ++ TL NIN+ V+ L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDDPLSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ+ G L+ S+ +H LL LR ++ F+ TP GRI+NRF+KD+ ID+ L NI +I + +++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRK-NYKNKAR-VEPKAQFSNGNVTFENPHGEKNGRKKGMAS---IMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFL--NSEELDPNSVLHDSSKP-HPMSIENGEFSWGDE--ITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVATNFFSSLAISLGCLKCSQLLHQTLLYYNLRWPMELFDTTPLGRIVNRFSKDIDTIDNVLPFNIRVVIGQAYMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 85.1149 bits (209), Expect = 3.980e-16 Identity = 120/512 (23.44%), Postives = 225/512 (43.95%), Query Frame = 2
Query: 2447 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVT-GILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 3907
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ + N+ S+ LV +++ +++ IL L+ AE + VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQ---VSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15]) HSP 1 Score: 829.706 bits (2142), Expect = 0.000e+0 Identity = 509/1322 (38.50%), Postives = 785/1322 (59.38%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKY---LKENLRSP--NIESEIHD---IEDKKCLIGKKNFNEEFKYSGK-FVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAP--IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKNQNNLIQ--------PSAPNKRKRSRLSTSGS----QGFDGNENAEENYEKYF--NDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE+ +S LS+IT+ W+ + + +K ++++ + LNN + S ++C+K + + L SP + E D +E+ + L+ K + +G+ + +LCR + P + KI D+L+ P +L+LL+ ++ + TW G L F +L F + +R+R A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ ITY + S P Q+ILA+ L+ LG S+ AGV + ++PLN +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F K+ IR E++ ++ ++ I + W PF V TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL S +E D +N + R G P I I +G+FSW++D PTL IN+++ L+AVVG VG GKSSLLSA+LGEM+ G+V +G +AYVPQ+AWIQN TL++NIL + +Y KV++AC L D+E LP D TEIGE+GVNLSGGQKQRVS+ARAVY + +YLLDDPLSAVD +VG+ +F K+I QGLL+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L+ F FL N ++ +++ + + P+A ++ + L+ +G+ Q + N++A K + ++ ++ +GRV L S+ W Y KA G+ + SI + +F L + G N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ N+ + W + G+I + F L+Y +L + +I++NI GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI +GLH+LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ +SLE++ + +V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKA-----LQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAP-TWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFL--SHEELDDDN-VERPAISGTPDSIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVD-GEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANTGRVKL-SVFWEYMKAIGLPL---SIFSIFLFFCHHLSSLGSNYWLSLWTD------DPVVNNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYK 1510
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15]) HSP 1 Score: 826.239 bits (2133), Expect = 0.000e+0 Identity = 506/1306 (38.74%), Postives = 773/1306 (59.19%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKY---LKENLRSP--NIESEIHD---IEDKKCLIGKKNFNEEFKYSGK-FVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAP--IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYF--NDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE+ +S LS+IT+ W+ + + +K ++++ + LNN + S ++C+K + + L SP + E D +E+ + L+ K + +G+ + +LCR + P + KI D+L+ P +L+LL+ ++ + TW G L F +L F + +R+R A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ ITY + S P Q+ILA+ L+ LG S+ AGV + ++PLN +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F K+ IR E++ ++ ++ I + W PF V TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL S +E D +N + R G P I I +G+FSW++D PTL IN+++ L+AVVG VG GKSSLLSA+LGEM+ G+V +G +AYVPQ+AWIQN TL++NIL + +Y KV++AC L D+E LP D TEIGE+GVNLSGGQKQRVS+ARAVY + +YLLDDPLSAVD +VG+ +F K+I QGLL+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L+ F FL ++ + + + S S+G N++A K + ++ ++ +GRV L S+ W Y KA G+ + SI + +F L + G N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ N+ + W + G+I + F L+Y +L + +I++NI GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI +GLH+LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ +SLE++ + +V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 217 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKA-----LQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAP-TWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFL--SHEELDDDN-VERPAISGTPDSIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVD-GEITEMGSYTELLGRQGAFAEFLRTYTN------------TEQEEGEESLGGEQTSEGLSSNDDAAATKTKSAEASRLTEADKANTGRVKL-SVFWEYMKAIGLPL---SIFSIFLFFCHHLSSLGSNYWLSLWTD------DPVVNNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYK 1490
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523]) HSP 1 Score: 816.609 bits (2108), Expect = 0.000e+0 Identity = 514/1367 (37.60%), Postives = 788/1367 (57.64%), Query Frame = 2
Query: 32 NPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-------SENSEKCLKYLKENLRSPNIESEIH-DIEDKKCLIGKKNFNEEF------------------------KYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSG----SQGFDGNENAEENYEKYFNDISH----------------------------------EEEIM-SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTF-NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 3916
NPE ++ LS+IT+ W + +++ FK + E +DLN +++ + K LK + NL+ + D E + L K +++ Y +++ ++ + + ++ + K+ +D+L P +LKL++ + +NKD SY W G L A+L S+ F + ++VR A+ +YKK L +S ++R +AG+IVN+ S D ++ + + + SCP QI L+I L++ELG S+ +G+ + ++P+N + SR+F + + FKD RM I+ ++ +G+KI+K YAWE F +++EIR E+K +R + + + ++ P V TF F+ P++++ EK F S+ LFN L+ P+ +LP +S + VS R+E FL + + ++ S A + + NG+++W D P L ++L+++ +L+AVVG VG GK+SL+SA+LGE++++ G + G +AYVPQ+AWIQN TL++NIL S ++ Y V+ AC LE D++ LP RDQTEIGE+G+NLSGGQKQRVSLARAVY +D+YLLDDPLSAVD +VG+ LF K+I GLL+ KTR+LVTHG+ +LP+VDEI V+ G +SE G+YE L F FL E+ K + N++N + +A + T +Q E+ + K N + H E+E+M +GRV + + Y A G + G S + I V N+WL D N T+ N R++ I +G +GL Q V G + AS+ +H+ LL +L+ + FF+ TPSGRI+NRF KD+F +D + ++ I + ++ +L VI + TP F V +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF + +FAV++R SL++ LVGLSISYAL VT LNWL R +E ETN V++ER+R+Y I E+ T+ ++W S GNI E++ ++Y L VL +T +I EKIG+VGRTGAGKSSL LFR+VE GRI ID ++I ++GLH LR +LTI+PQDPV+FSGTL+ NLDPF ++D ++ LE++ + ++V L G+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D +++ LD G I+EF SP ELLS GHF ++A+ D I+ E++
Sbjct: 207 NPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKKARNNLQKKKSKKRKTVDAEGQNGL--AKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKD-SYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDLDT---TTVTHNSSITAAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALEPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVLV-HGVVSEIGSYESLRASKGAFSEFL-ETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDTR---IGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEDTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK-PGHFSSMAE-DAGIRREEE 1560 HSP 2 Score: 69.3218 bits (168), Expect = 3.199e-11 Identity = 97/434 (22.35%), Postives = 190/434 (43.78%), Query Frame = 2
Query: 794 GAVIPLNII---IMKF----SRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRN--VSVGWCIMSV--LWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDS---NNSMPRKMSPGAP-IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNN 2011
V+P+ ++ + +F SR+ + + + S E G+ +I+ Y + F K E+ + +K++ VS W M + L +LV FF F +SL + +S+ N+ + L S+ + +V+ R+ + +E +N++ + P P A I ++ + + L+ + ++++ + I +VGR G GKSSL + + + +G + ++ +PQ+ + + TLR N+ ++F+ VL+ L+ + LP + E+ E G NLS GQ+Q + LARA+ + S I +LD+ +AVD+ L I + H T + + H L + + V+ D G+I E + L+ F S ++ + ++ Q+
Sbjct: 1143 AVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEDTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFA-----ALFAVISRDSL-NSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREY---AEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLET-DDLIQSTIRRE--FSHCTVLTIAHRLNTILDSSRVMVL-DSGKIVEFDSPNELLSKPGHFSSMAEDAGIRREEEQSQ 1563
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523]) HSP 1 Score: 815.068 bits (2104), Expect = 0.000e+0 Identity = 515/1367 (37.67%), Postives = 789/1367 (57.72%), Query Frame = 2
Query: 32 NPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-------SENSEKCLKYLKENLRSPNIESEIH-DIEDKKCLIGKKNFNEEF------------------------KYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA---PNKRKRSRLSTSGSQGFDGN-ENAEENYEKYFNDISH----------------------------------EEEIM-SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTF-NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 3916
NPE ++ LS+IT+ W + +++ FK + E +DLN +++ + K LK + NL+ + D E + L K +++ Y +++ ++ + + ++ + K+ +D+L P +LKL++ + +NKD SY W G L A+L S+ F + ++VR A+ +YKK L +S ++R +AG+IVN+ S D ++ + + + SCP QI L+I L++ELG S+ +G+ + ++P+N + SR+F + + FKD RM I+ ++ +G+KI+K YAWE F +++EIR E+K +R + + + ++ P V TF F+ P++++ EK F S+ LFN L+ P+ +LP +S + VS R+E FL + + ++ S A + + NG+++W D P L ++L+++ +L+AVVG VG GK+SL+SA+LGE++++ G + G +AYVPQ+AWIQN TL++NIL S ++ Y V+ AC L D++ LP RDQTEIGE+G+NLSGGQKQRVSLARAVY +D+YLLDDPLSAVD +VG+ LF K+I GLL+ KTR+LVTHG+ +LP+VDEI V+ G +SE G+YE L F FL E+ K + N++N + +A P + L DG+ E+ + K N + H E+E+M +GRV + + Y A G + G S + I V N+WL D N T+ N R++ I +G +GL Q V G + AS+ +H+ LL +L+ + FF+ TPSGRI+NRF KD+F +D + ++ I + ++ +L VI + TP F V +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF + +FAV++R SL++ LVGLSISYAL VT LNWL R +E ETN V++ER+R+Y I E+ T+ ++W S GNI E++ ++Y L VL +T +I EKIG+VGRTGAGKSSL LFR+VE GRI ID ++I ++GLH LR +LTI+PQDPV+FSGTL+ NLDPF ++D ++ LE++ + ++V L G+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D +++ LD G I+EF SP ELLS GHF ++A+ D I+ E++
Sbjct: 193 NPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKKARNNLQKKKSKKRKTVDAEGQNGL--AKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKD-SYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDLDT---TTVTHDSSITAAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVLV-HGVVSEIGSYESLRASKGAFSEFL-ETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDTR---IGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK-PGHFSSMAE-DAGIRREEE 1546 HSP 2 Score: 68.9366 bits (167), Expect = 4.079e-11 Identity = 97/434 (22.35%), Postives = 189/434 (43.55%), Query Frame = 2
Query: 794 GAVIPLNII---IMKF----SRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRN--VSVGWCIMSV--LWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDS---NNSMPRKMSPGAP-IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNN 2011
V+P+ ++ + +F SR+ + + + S E G+ +I+ Y + F K E + +K++ VS W M + L +LV FF F +SL + +S+ N+ + L S+ + +V+ R+ + +E +N++ + P P A I ++ + + L+ + ++++ + I +VGR G GKSSL + + + +G + ++ +PQ+ + + TLR N+ ++F+ VL+ L+ + LP + E+ E G NLS GQ+Q + LARA+ + S I +LD+ +AVD+ L I + H T + + H L + + V+ D G+I E + L+ F S ++ + ++ Q+
Sbjct: 1129 AVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFA-----ALFAVISRDSL-NSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREY---AEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLET-DDLIQSTIRRE--FSHCTVLTIAHRLNTILDSSRVMVL-DSGKIVEFDSPNELLSKPGHFSSMAEDAGIRREEEQSQ 1549
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc6b.2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-110208-2]) HSP 1 Score: 793.112 bits (2047), Expect = 0.000e+0 Identity = 471/1305 (36.09%), Postives = 753/1305 (57.70%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSE-----NSEKCLKYLKENLRSPNI-ESEIHDIEDKKCLIGKKNFNEEFK--YSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPG-APIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLM---DFGTEFKSF-LNESSDKVD-----KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEK-YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI-NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 3889
P +S LS++ + W + + + ++ +K E + L +TS + E ++ K + ++ E++ + C+ K+ F + FK +G + ++L +++ P G + + +D ++ + LL + + WKG L A F SL + + +RV+ A+ G++Y+K+L +++ AR + G+IVN+ S D +++++ + Y P +I L + L+ LG S AG+T + + PLN I K K E ++ KD+R+ ++ EI G+KI+K YAWEK F +++ R E+ ++ + + + ++ + + F ++ ++ +KIFVS+ L N L+ P+ LP +S + +VS R+ FL E + DS +P +P + I NG+FSW++D P L IN+ V+ L+AVVG VG GKSSLLSA+LGEM +G + G + YVPQ+AWIQN TL++NIL Y KVL+AC L D+E LP RD TEIGE+G+NLSGGQKQRVSLARAVY++SDIYLLDDPLSAVD +VGQ +F K+I G LK+KTRVLVTHGL +LP D I V+ D G+I E G+Y L+ + E K+F ++E + K+ + L R L ++ Q + + + N ++ ++ ++ +GRV L V YF+ G+ I V N WL + AD + N ++ + + YG +G Q +A+ GG+ AS+++H LL+ VL S + FF +TPSG +LNRF+K++ ID + + ++ L+ +++ + TP+ G++ +P+ + Y +Q FY+++S Q RRL+S + S + TH ET G+S+IR+ + F +D + ++++ RWL + L+ LGNL+V + I +V+ R +LS VGL++S++LQVTGIL+W+ R + E N VS+ER+++Y E+ ++ + +W +G+I + + LQY L LK I++++N EK+G+VGRTGAGKSSLAL +FR++E G+IFIDG+NI IGLH+LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ +SLE++ + +V+ L + +N++C G NLS+GQ+QLICLAR LL+K+KI++LDEATA+VD +TD + I+ QF TV+ IAHRL TI+D ++I +D G+I E SP L+S ++ +A
Sbjct: 207 PVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQKKSSLNEAQTLGFKLSSCV--KQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQD-ALMFSIPQVLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAPLSQLPIAMSTTMQVVVSLKRLGTFLDQDELKLDSVQRVP--YNPNIESVVINNGTFSWSKDSTPCLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVMAD-GEIKEMGSYAELLSRKNAFAELKAFSVSERKESATLKGTRKSVSFLSIKDFSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAFIIPIIFLYAFQQVASLAYNYWLSLWAD------DPVINGTQVNTDLKLGVYGALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSPLPSDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQFYRMCREA 1499
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]) HSP 1 Score: 843.188 bits (2177), Expect = 0.000e+0 Identity = 511/1347 (37.94%), Postives = 769/1347 (57.09%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKK-----NFNEEFKYSGKFVI------------KSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWK---GILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDIS-------------------------------------HEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFG---NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ + LS++T+ W K +K ++D+ + LN +TS+ +K E E ++ + KK N +E Y +I K L R + P G K+F+D+L P +L +L+ ++KNKD W +LM L Q L YCF +R+R+A+ G+IY+K+L ++ A+ + G++VN+ SVD ++ + T+ + S P QI LA+ L+ LG S+ AGV + +IP+N I +R F ++ +KD R+ ++ EI +G+K++K+YAWE F +K+ EIRN E+ ++ + + + W PF V TF ++ +++ EK FVSL LFN L+ P+ +LP +S A VS RI+NFL + E D N K PG I + NG+FSW ++G L NINL V + L+AVVG+VG GKSSL+SA+LGEM G V G +AYVPQ+AWIQN TL++NIL ++ N+ Y KVL+AC L D+E LP DQTEIGE+G+NLSGGQKQRVSLARAV+ ++D+YLLDDPLSAVD +V + +F+ +I GLL+ KTRVLVTHG+ +LP VD I V+ D G+++E G+Y+ L+ F FL + + + ++ P ++ + D A E +K+ IS E +GRV + Y KA G+ + S+ C ++ A NVWL N NQ++ + + + Y +G+ Q L V+ G+ A++K+HS LLD + + F++ TP GRI+NRF+KD+++ID + I + +++++VI TP F +V IP+ I YI +Q FY+++SRQ +RL+S + S + +H ET +G+SIIR+ ++ F + +D++ K +S RWL +R++ +GN +V + +FAVL R LS LVGLS+SYALQVT LNW+ R ++ ETN V++ER+++Y E+ I +T E+W S G + L N+S++Y L VLKN+ + +NGGEK+G+VGRTGAGKSS+ L LFR++E G + ID VNI+ IGL LR +LTI+PQDPV+FSGTL+ NLDPF++Y+DD++ K+LE+S + +V + Y+C G NLS+GQ+QL+CLAR LL+K++I+ILDEATA++D ETD + I+ QF TV+ IAHRL TI+D +++ LD G I EF +P L++ G F +A+
Sbjct: 208 PESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIK---------EWEKEKSNLAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTG----MRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFL--ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVD-GRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAI---SVFICFLYSCQNAAAIGANVWLS------DWTNEPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKP--PEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIA-LKGIFYGMAK 1526 HSP 2 Score: 92.8189 bits (229), Expect = 3.380e-18 Identity = 78/299 (26.09%), Postives = 137/299 (45.82%), Query Frame = 2
Query: 3038 LNWLTRQCAEFETNAVSIERIRQYTMIPVESINETN-NYISENWVSNGN-INLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA--DEYIKHED 3913
LN L + + +VSI+RI+ + + +E + N ++++ GN I + N + + N +L+NI + + G + VVG+ G GKSSL AL +E G + + G + +PQ I + TLK N+ + K LE ++ + L G + G G NLS GQKQ + LAR + + + +LD+ ++VD + + + + T +++ H + + D I+ L DG + E GS +ELL + + L D+ ++ ED
Sbjct: 590 LNMLPQVISNLAQASVSIKRIQNFL-----ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRG-------------SVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEED 870
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 833.558 bits (2152), Expect = 0.000e+0 Identity = 512/1315 (38.94%), Postives = 783/1315 (59.54%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSE-------------NSEKCLKYLKENLRSPNIESEI----HDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRL-----------------STSGSQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 3871
PE+ +S LSQIT+ W+ + + Q FK ++ + + LN + S E N K K + + SP +++ D+ ++ + K +E + S ++K+L + + P F K F D+L+ + P +L+LL+ ++ +KD W G L L FF +L + F I +R++ A+ G++Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA LL+ LG S+ AG+ + ++P+N +I ++K+ ++ KD R+ ++ EI +G+K++K+YAWE F +K+ IR DE+K ++ + + + W PF V TF ++ +++ EK FVSL LFN L+ P+ +LP +S + A VS R+ FL E E +S P+K S G+ I +++ +FSW+ + P+L +IN+++ L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDDPLSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ + N Q P+ ++ SRL ++S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 203 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPS---LLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKSSEGS-INMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYANA----EQNKDQEGKPSNQEESRLYLNRFHIHFLFNFRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1501
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 833.173 bits (2151), Expect = 0.000e+0 Identity = 517/1312 (39.41%), Postives = 787/1312 (59.98%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-------SENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEE-----FKYSGK----FVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA-PNKRKR-------------SRLSTSG-SQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 3871
PE+ +S LSQIT+ W+ + + Q FK ++ + + LN + S S+N EK +Y K + ++ + K L K++ EE K + K ++K+L + + P F K F D+L+ + P +L+LL+ ++ +KD W G L L FF +L + F I +R++ A+ G++Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA LL+ LG S+ AG+ + ++P+N +I ++K+ ++ KD R+ ++ EI +G+K++K+YAWE F +K+ IR DE+K ++ + + + W PF V TF ++ +++ EK FVSL LFN L+ P+ +LP +S + A VS R+ FL E E +S P+K S G+ I +++ +FSW+ + P+L +IN+++ L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDDPLSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ ++N++ PS P++ KR +LS S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 193 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEK--EYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKSSEGS-INMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYAN-AEQNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1492
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]) HSP 1 Score: 831.632 bits (2147), Expect = 0.000e+0 Identity = 489/1238 (39.50%), Postives = 730/1238 (58.97%), Query Frame = 2
Query: 311 IKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWK---GILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDIS-------------------------------------HEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFG---NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
+K L R + P G K+F+D+L P +L +L+ ++KNKD W +LM L Q L YCF +R+R+A+ G+IY+K+L ++ A+ + G++VN+ SVD ++ + T+ + S P QI LA+ L+ LG S+ AGV + +IP+N I +R F ++ +KD R+ ++ EI +G+K++K+YAWE F +K+ EIRN E+ ++ + + + W PF V TF ++ +++ EK FVSL LFN L+ P+ +LP +S A VS RI+NFL + E D N K PG I + NG+FSW ++G L NINL V + L+AVVG+VG GKSSL+SA+LGEM G V G +AYVPQ+AWIQN TL++NIL ++ N+ Y KVL+AC L D+E LP DQTEIGE+G+NLSGGQKQRVSLARAV+ ++D+YLLDDPLSAVD +V + +F+ +I GLL+ KTRVLVTHG+ +LP VD I V+ D G+++E G+Y+ L+ F FL + + + ++ P ++ + D A E +K+ IS E +GRV + Y KA G+ + S+ C ++ A NVWL N NQ++ + + + Y +G+ Q L V+ G+ A++K+HS LLD + + F++ TP GRI+NRF+KD+++ID + I + +++++VI TP F +V IP+ I YI +Q FY+++SRQ +RL+S + S + +H ET +G+SIIR+ ++ F + +D++ K +S RWL +R++ +GN +V + +FAVL R LS LVGLS+SYALQVT LNW+ R ++ ETN V++ER+++Y E+ I +T E+W S G + L N+S++Y L VLKN+ + +NGGEK+G+VGRTGAGKSS+ L LFR++E G + ID VNI+ IGL LR +LTI+PQDPV+FSGTL+ NLDPF++Y+DD++ K+LE+S + +V + Y+C G NLS+GQ+QL+CLAR LL+K++I+ILDEATA++D ETD + I+ QF TV+ IAHRL TI+D +++ LD G I EF +P L++ G F +A+
Sbjct: 309 LKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTG----MRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFL--ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVD-GRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAI---SVFICFLYSCQNAAAIGANVWLS------DWTNEPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKP--PEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIA-LKGIFYGMAK 1527 HSP 2 Score: 92.4337 bits (228), Expect = 4.286e-18 Identity = 78/299 (26.09%), Postives = 137/299 (45.82%), Query Frame = 2
Query: 3038 LNWLTRQCAEFETNAVSIERIRQYTMIPVESINETN-NYISENWVSNGN-INLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA--DEYIKHED 3913
LN L + + +VSI+RI+ + + +E + N ++++ GN I + N + + N +L+NI + + G + VVG+ G GKSSL AL +E G + + G + +PQ I + TLK N+ + K LE ++ + L G + G G NLS GQKQ + LAR + + + +LD+ ++VD + + + + T +++ H + + D I+ L DG + E GS +ELL + + L D+ ++ ED
Sbjct: 591 LNMLPQVISNLAQASVSIKRIQNFL-----ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRG-------------SVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEED 871
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 828.935 bits (2140), Expect = 0.000e+0 Identity = 515/1312 (39.25%), Postives = 784/1312 (59.76%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-------SENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEE-----FKYSGK----FVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA-PNKRKR-------------SRLSTSG-SQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 3871
PE+ +S LSQIT+ W+ + + Q FK ++ + + LN + S S+N EK +Y K + ++ + K L K++ EE K + K ++K+L + + P F K F D+L+ + P +L+LL+ ++ +KD W G L L FF +L + F I +R++ A+ G++Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA LL+ LG S+ AG+ + ++P+N +I ++K+ ++ KD R+ ++ EI +G+K++K+YAWE F +K+ IR DE+K ++ + + + W PF V TF ++ +++ EK FVSL LFN L+ P+ +LP +S + A VS R+ FL E E +S P+K I +++ +FSW+ + P+L +IN+++ L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDDPLSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ ++N++ PS P++ KR +LS S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 168 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEK--EYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKTE--GSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYAN-AEQNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1466
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]) HSP 1 Score: 829.706 bits (2142), Expect = 0.000e+0 Identity = 505/1330 (37.97%), Postives = 776/1330 (58.35%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR----------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKN-------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ + +++ ++ + LN +TS E ++C K K+ +R P S++ E+ + LI K + + K L + + P ++ K D+++ P +L+L++N++ +++ W+G L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ L+L LG S+ AGV + ++PLN ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF F+ +++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V++AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY +SDIYL DDPLSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F FL N D ++ +N ++ K + LS S S D ++ E E ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D ++N + N++ F ++ YG +G+ Q A+ + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G + E G+P ELL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDR----EPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAP-DWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQL-SVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN-----FRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 811.216 bits (2094), Expect = 0.000e+0 Identity = 462/1188 (38.89%), Postives = 721/1188 (60.69%), Query Frame = 2
Query: 452 TWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ-----------------------PSAPNKRKR--SRLSTSGSQGFDGNENAEENY------------EKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAF---GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
TW G L+A L F +L + + + +R+R A+ G+IY+K L ++ + + G++VN+ SVD ++ M+ + + S P Q+ILAI L+ LG S AGV I +IPLN + + + +++ FKD R+ +++EI +G+K++K+YAWE F ++++ IR E++ +R + I + +W PF V IT ++Y ++++ EK FVSL LFN L++P+ +LP +S A VS RI++FL ++ E D + +SPG I I NG+F+W +D PTL+++N+ + L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L + N Y + L+ C L D++ LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D++I+LLDDPLSAVD +V + +F+++I +G+L KTRVLVTHG+ +LP D I V+ GQ+SE G Y L+ F +FL + D+ + +Q P+ RK+ +S+ S+G N + + K + EE +G V L S+ W Y K+ G+ +++ C+++G A NVWL + N++ + +N + Y +G+ Q L V+L + G ++A++ +H LL +RS FF+ TPSGRILNRF+KD+++ID L I ++N I++++VI TP F +V +P+ + Y +Q FY+++SRQ +RL+S + S + +H ET +G+S+IR+ DF+ + +D + K S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SYALQVT LNW+ R ++ E+N +++ER+++Y+ E+ + E+N E W + G + N+S++Y L VLKN+T+++ GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + ++LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS++++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D ++++ LD G + EF SP L++ + G F +A+
Sbjct: 345 TWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFL--NQNELDPQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAG-GQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKL-SVYWDYAKSMGL---CTTLSICLLYGGQSAAAIGANVWLSAWS------NDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNR-APEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIFYGMAK 1517
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 809.29 bits (2089), Expect = 0.000e+0 Identity = 463/1189 (38.94%), Postives = 723/1189 (60.81%), Query Frame = 2
Query: 452 TWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-NESSDKVDKNQNNLIQ-----------------------PSAPNKRKR--SRLSTSGSQGFDGNENAEENY------------EKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAF---GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
TW G L+A L F +L + + + +R+R A+ G+IY+K L ++ + + G++VN+ SVD ++ M+ + + S P Q+ILAI L+ LG S AGV I +IPLN + + + +++ FKD R+ +++EI +G+K++K+YAWE F ++++ IR E++ +R + I + +W PF V IT ++Y ++++ EK FVSL LFN L++P+ +LP +S A VS RI++FL ++ E D + +SPG I I NG+F+W +D PTL+++N+ + L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L + N Y + L+ C L D++ LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D++I+LLDDPLSAVD +V + +F+++I +G+L KTRVLVTHG+ +LP D I V+ GQ+SE G Y L+ F +FL N + D+ ++ +Q P+ RK+ +S+ S+G N + + K + EE +G V L S+ W Y K+ G+ +++ C+++G A NVWL + N++ + +N + Y +G+ Q L V+L + G ++A++ +H LL +RS FF+ TPSGRILNRF+KD+++ID L I ++N I++++VI TP F +V +P+ + Y +Q FY+++SRQ +RL+S + S + +H ET +G+S+IR+ DF+ + +D + K S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SYALQVT LNW+ R ++ E+N +++ER+++Y+ E+ + E+N E W + G + N+S++Y L VLKN+T+++ GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + ++LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS++++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D ++++ LD G + EF SP L++ + G F +A+
Sbjct: 345 TWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFL--NQNELDPQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAG-GQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKL-SVYWDYAKSMGL---CTTLSICLLYGGQSAAAIGANVWLSAWS------NDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNR-APEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIFYGMAK 1518
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:MGI Symbol;Acc:MGI:1352447]) HSP 1 Score: 758.829 bits (1958), Expect = 0.000e+0 Identity = 513/1361 (37.69%), Postives = 784/1361 (57.60%), Query Frame = 2
Query: 26 TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNN---------------TETSSENSEKCLKYLKENLRSP--------NIESEIHDI---EDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKG----ILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSP-GAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD----FGTEFKSFLNESSDKVDKNQNN----------LI--------QPSAPNKRKRSRLSTSGSQGFDGNENAEENYE-----KYFNDISHEEEIM------------SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQ--AF--GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
T P +S LS +T+ W D + + +K + E +D+ T+ + + + LK++ +SP +S+ D+ ED K K ++F S +++K+L + ++ +I +ILK+ DIL+ P +LK L+ ++K+ D SY W G ILM + Q F +CF + + VR + +YKK L LS AR ++ G+ VN+ SVD +++M+ Y + S QI L+I L+ ELG SI AGV + ++P+N ++ RK + + KDKR+ I+ EI G+KI+K +AWE F +++ IR E++N+ S I+ + L P V ITF+ ++ +++ EK F S+ LFN L+ P+ +LP +S I A VS R+E +L +D + S R + ++ SF+W D T+ ++NL+++ +L+AVVG VG GKSSL+SA+LGEM ++G + +G IAYVPQ+AWIQN T+++NIL +++ Y +V++AC L D+E LP D EIGE+G+NLSGGQK RVSLARA YQD+DIY+LDDPLSAVD +VG+ +FNK++ GLL KTR+LVTHG+ +LP VDEI V+ +G I E+G+Y LMD F +K+F+ S + + +N LI ++ R+ + L + S+ ++ + K N ++ +EE++ +G+V + + Y +A G + S+L VIF VL AF N+WL N + + S+ + I +G +G+ Q + ++ I+ ASK +H LL +LR+ + FF+ TP+GRI+NRF D+ +D TL + + ++++LV+I + TP F I+ IP+ I Y+ +QVFY+++SRQ RRLDS S + +H ET SG +IR+ E + F + + ID + K S RWL +RL+++GNLIVF S + V+ + SL+ VG +S AL +T LNWL R +E ETN V++ERI +Y + E+ T+ +W G I N+ ++Y L VLK IT NI EK+GVVGRTGAGKSSL LFR++E G+I IDG++I SIGLH LR +LTI+PQDP++FSG L+ NLDPF++Y+D+++ ++LE++ + +V L G+ ++ G NLS+GQ+QL+CL R +L+KSKI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D DKI+ LD G I+E+GSP+ELLSN G F +A+
Sbjct: 190 THAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKS--WLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPD-SYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFVLG----MTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYL----GSDDLDLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLG-KGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWW----SLLFIVIFYVLNYVAFIGTNLWLSAWTSDSEKQNGTDNSPSQRDMR--IGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSN-MGPFYLMAK 1531
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc6 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6 [Source:MGI Symbol;Acc:MGI:1351634]) HSP 1 Score: 648.662 bits (1672), Expect = 0.000e+0 Identity = 402/1169 (34.39%), Postives = 638/1169 (54.58%), Query Frame = 2
Query: 446 SYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYS--------WIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQ-------NNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND------ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISEN-WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
S W G L+A+L F +L E + +R+R A+ G++Y+K L LS+ +R +AGD+VN+ SVD++++ +I Y WIF+ + L+ LG S V +++PLN I K E ++ K R + + + ++ IK + WE F +++ IR E+ ++ ++ + + V + + F V + F ++ + EK FV+L + + L LP+ + + A VSF R+ FL E + + + + S I + NG+F+W+++ P L+ INL V L+AVVG VG GKSSLLSA+LGE+ + G+V EG +AYVPQEAW+QN ++ N+ + + + KVLDAC L D+ S P T IGE+G+NLSGGQKQR+SLARAVY+ + IYLLDDPL+A+D +V Q +F ++I GLL+ TR+LVTH L LP D I V+ + G I+E G+Y+ L+ L+ + + P R R + + G +E E +D + E+ + GRV + Y +A G + ++ + V WL + AD + + + A +G++G Q + + GG RAS + LL V RS + FF TP G +LNRF+K+ +D + + ++ L+ + +++ TP + +P+++ Y Q Y+++S Q RRL+S S V +H+ ET+ GS ++R+ A++ F + +D++ + + ++ RWL L++LGN +VF + AVL++ LSA LVG S+S ALQVT L W+ R + E + V++ER++ Y IP E+ ++ W G I +F L++ LP ++ +++ I+ GEK+G+VGRTGAGKSSLA L RL E G I+IDGV I +GLH LR ++TI+PQDPV+F G+L+ NLD E+TD+ + +LE + +V SL + Y+C G +LS+GQKQL+CLAR LL+K++I+ILDEATASVD T+ ++ A++ F TV++IAHRL++++DC +++ +D+G + E GSP +LL+ G F LA
Sbjct: 342 SSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVY--------LWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLAN-GTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRP-DRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWAD------DPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQ-KGLFYRLAH 1493
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q8CG09|MRP1_RAT (Multidrug resistance-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Abcc1 PE=1 SV=2) HSP 1 Score: 834.328 bits (2154), Expect = 0.000e+0 Identity = 511/1334 (38.31%), Postives = 784/1334 (58.77%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR----------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE--------SSDKVDKN------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ + Q +++ +K + LN +TS E ++C+K K+ +R P S++ E+ + LI K + + + K L + + P ++ K D+++ P +L+L++N++ +++ W+G L L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ LA+ L+L LG S+ AGV + ++P N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF F+ +++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS K G I ++N +F+W D PTLN I + + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + + Y V++AC L D+E LP+ D TEIGE+GVNLSGGQKQRVSLARAVY +SDIYLLDDPLSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F F+ +S+ KN +N ++ A K + LS S S N+ E + + E ++ +G+V L S+ W Y KA G+ + SI + V N WL + D + +N + ++RN F ++ YG +G+ Q +AV + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF STV+ IAHRL TI+D ++I LD G I E G+P ELL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDR----DPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAP-DWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKL-SVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGT--QENRN---FRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELL-QQRGVFYSMAK 1527
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O35379|MRP1_MOUSE (Multidrug resistance-associated protein 1 OS=Mus musculus OX=10090 GN=Abcc1 PE=1 SV=1) HSP 1 Score: 829.706 bits (2142), Expect = 0.000e+0 Identity = 505/1330 (37.97%), Postives = 776/1330 (58.35%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR----------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKN-------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ + +++ ++ + LN +TS E ++C K K+ +R P S++ E+ + LI K + + K L + + P ++ K D+++ P +L+L++N++ +++ W+G L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ L+L LG S+ AGV + ++PLN ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF F+ +++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V++AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY +SDIYL DDPLSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F FL N D ++ +N ++ K + LS S S D ++ E E ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D ++N + N++ F ++ YG +G+ Q A+ + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G + E G+P ELL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDR----EPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAP-DWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQL-SVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN-----FRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|P33527|MRP1_HUMAN (Multidrug resistance-associated protein 1 OS=Homo sapiens OX=9606 GN=ABCC1 PE=1 SV=3) HSP 1 Score: 822.387 bits (2123), Expect = 0.000e+0 Identity = 505/1339 (37.71%), Postives = 778/1339 (58.10%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSEN--------SEKCLKYLKENLR---------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS+IT+ W+ I + +++ ++ + LN +TS + ++C K K+ ++ P S++ E+ + LI K +E+ S + K L + + P + K D+++ + P +LKLL+ ++ + W+G +L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++P+N ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ + FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K G I ++N +F+W PTLN I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D +N + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP-QKEWNPS---LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP-DWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q6UR05|MRP1_CANLF (Multidrug resistance-associated protein 1 OS=Canis lupus familiaris OX=9615 GN=ABCC1 PE=1 SV=1) HSP 1 Score: 822.002 bits (2122), Expect = 0.000e+0 Identity = 510/1336 (38.17%), Postives = 775/1336 (58.01%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-----------------SENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN----------ESSD----------KVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEE--------EIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-----NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE+ +S LS++T+ W+ + + +++ ++ + LN +TS S+ ++ + Y ++ P S++ E+ + LI K E + K L + + P ++ K D+++ P +LKLL+N++ +K W+G L L F +L + F I +R++ A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+L LG S+ AGV + ++PLN ++ ++ + + KD R+ ++ EI +G+K++K+YAWE F K+ IR +E+K ++ + + + W PF V TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL E E DS P K GA I ++N +F+W PTL+ I ++ L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + + +Y V++AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY DSDIYL DDPLSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V+ G+ISE G+Y+ L+ F FL E D +V + +N ++ K+ + +LS S S D + + E +E+ + +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q + V + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I + ++I + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +F+V++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ E I E W G + ++ L+Y NL VLK+I I INGGEK+G+VGRTGAGKSSL L LFR+ E G I ID +NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V+ L + +N +C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E G P +LL G F ++A+
Sbjct: 209 PESSASFLSRVTFWWITGLMVRGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSKRQQRKITYSSKDPAKPKGGSQVDVNEEAEVLIVKTPQKER----EPSLFKVLYKTFGPYFLMSFLFKALHDLMMFAGPEILKLLINFVNDKKAP-DWQGYLYTALLFICACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGANSITVKNATFTWARSDPPTLSGITFSIPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGRQLQERYYKAVIEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRLLVTHSISYLPQVDVIIVMTG-GKISEMGSYQELLARDGAFAEFLRTYASGDQEQAEQDDGLTGVSSPGKEVKQMENGMLVTDVAGKQLQRQLSNSSSYSGDVSRHHTSTAELQKAGPKNEDAWKLVEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTD------DPIVNGTQEHTKIRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLHVDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPIASIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFSVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYS----ETEKEAPWQIQEMAPPSTWPQVGRVEFRDYGLRYRENLDLVLKHINITINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDDINIAKIGLHDLRVKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSGLPDKLNQECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIRECGQPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q5F364|MRP1_CHICK (Multidrug resistance-associated protein 1 OS=Gallus gallus OX=9031 GN=ABCC1 PE=2 SV=1) HSP 1 Score: 819.691 bits (2116), Expect = 0.000e+0 Identity = 512/1330 (38.50%), Postives = 781/1330 (58.72%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSE---------------NSEKCLKYL---KENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---------ESSDKVDKN-------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEEN---------YEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE---SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S LS+IT+ W+ + Q + ++ + + LN +TS E + L L K+ +S + E+ +E+ + LI K + + S + K L + + P ++ K D+L+ T P +LKLL+N++ NK W+G L F +L + F I +R++ A+ G+IY+K L ++ AR + G+IVN+ SVD ++ M+ TY + S P Q+ILA+ LL+ LG S+ AGV + ++P+N ++ ++ + ++ KD R+ ++ EI +G+K++K+YAWE F +K+ EIR E+K ++ + + + W PF V TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL E + DS P + G+ I ++N +FSW++ P+LN+IN V LIAVVG+VG GKSSLLSA+LGEM G V +G IAYVPQ+AWIQN TL +NI+ + N+ Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++D YL DDPLSAVD +VG+ +F K+I +G+LK+KTRVLVTH + +LP +D I V+ D G+ISE G+Y+ L+ F FL ESSD + +N ++ A K +LS S + + ++ ++ EK ++ + +GRV Y KA G+++ S+ + + N WL + D + N ++ + YG +G+ Q +AV + GG+ AS+ +H LL VLRS + FF TPSG +++RF+K++ ID T+ I + T +I + ++I + TP +V P+ + Y+L+Q FY+++SRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV+ R LS L+GLS+SY+LQ+T LNWL R ++ ETN V++ER+++Y + E SI ET + W G + F L+Y +L VLKNI I INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDP++FSG+L+ NLDPFD+++D+ + +SLE++ + ++V+SL + +N++C G NLS+GQ+QL+CLAR LL+KSKI++LDEATA+VD ETD + IK QF TV+ IAHRL TI+D +++ LD G ++E SP LL + G F ++A+
Sbjct: 209 PEFSASFLSRITFWWITGLMIQGHRRPLEAKDLWSLNKEDTSEEIVPGLAKNWAKEWAKTKRQPLNMLYSSKKQQKSSDSNGEV--MEEAEALIIKPSQ----RSSEASLSKVLYKTFGPYFLMSFLFKAAHDLLMFTGPEILKLLINFVNNKSAP-NWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMGTFTWVCAPFLVALSTFAVYVKVNKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITNAEGS-IVVKNATFSWSKTDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSIAYVPQQAWIQNATLEDNIIFGREMNESRYKRVIEACALLPDLEILPMGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADTYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMTD-GEISEMGSYQELLKQDGAFAEFLRTYANAEQSMESSDASSPSGKEGKPVENGVLVNDATGKLMHRQLSNSSTYSRETGKSQHQSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWEYMKAIGLYISFLSVFLFMCNHIASLASNYWLSLWTD------DPVVNGTQQYTNVRLGVYGALGISQGIAVFGYSMAVSIGGIFASRHLHLDLLHNVLRSPMSFFERTPSGNLVSRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVVIPPLGLVYLLVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVIARNKLSPGLIGLSVSYSLQITAYLNWLVRMTSDLETNIVAVERVKEYAEMEKEAEWSIEETAP--ASTWPQEGKVEFRGFGLRYREDLDLVLKNINITINGGEKVGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECSEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDNLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECDSPDNLL-QAKGLFYSMAK 1520
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: R7VJB8 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_229313 PE=4 SV=1) HSP 1 Score: 868.226 bits (2242), Expect = 0.000e+0 Identity = 514/1278 (40.22%), Postives = 764/1278 (59.78%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKE--NDSNNSMPRKMSPGAPIEIQNGSFSWT--EDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND---ISHEEEIMSGRVSLNS--------IVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAK--FYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDK 3793
PE +S +S+IT+ W++ + +K+ +K+E + LN + +S K K+ L+ N ++ + KK + F +L +VY P + + K D+L P++ LL+ Y + D+ WKG L A LFF + S+ + F I + +RV+AAL IYKK L +S EAR + G+IVN+ SVD +++ + + Y W+ S P QI++A+ +L+ +G S+ AG+ + +IP+N ++ RK +++ KD+R+ ++ E+ G+K++K+YAWE F K+ EIR E++ ++ + + + W PF V +F ++ N + + FVSL LFN L+ PI ++P +S ++A VS RI FL + + N +NS API ++NG+F+W ED P L +I+L V++ L AVVG VG GKSSL+SAILGEM + G V G AYVPQ+AWIQN +LR+NIL K F+ Y KV++AC L D+E LP D TEIGE+G+NLSGGQKQRVSLARAVY D DIYLLDDPLSAVD +VG+ +F+ ++ +GLL+ KTR+LVTHG+ WLP VDE+ VI + G+ISE+G+YE L+ F FL E+SD D++++ + +R R +T G + EE D + +E GRV + + Y KA G+F+ +L+ +++ N+WL + L N S N ++ + Y+ YG +G+ Q V+L+ +RA+ K+H +L +LRS + FF+ TP GRILNRF++D+ +D+ L I +N +++++ VIS TP F V IP++I Y +Q FYI +SRQ +R++S S + H ET +G+S IR+ +A+ F + +D + F S RWL RL+ +G L+V + IFAV+ + +LS LVGLSISYALQVT LNW+ R ++ ETN VS+ERI +Y+ P E+ + + IS W G + E++S +Y + VL+ IT NI GEK+G+VGRTGAGKSSL ++LFR++E G I IDG+N++ +GLHQLR +LTILPQDPV+F+GTL+ NLDPFD+YTDDKL SL+ + + +++ SL G+ Y+CG G NLS+GQ+QL+CLARTLL+K+KI+ILDEATA+VD ETD + I+ F S T++ IAHRL TI+D D+
Sbjct: 199 PEVSASFISRITFFWINSLVRTGYKKSLKEEDVWALNPRDITSNTFHPFEKQWKKELQKCNWKASL-----KKAIPDPSLF------------ATLTKVYGPTLLIAHLCKFVCDLLTFVGPMLQSLLIEYTETPDMP-EWKGYLYAALFFITTVLTSVFFHQLFHIGMTLGMRVKAALIAAIYKKALTMSNEARKTSTVGEIVNLMSVDAQRMQDVVGYLWMVWSSPLQIVIAVYMLWNIMGPSVLAGLAVMILLIPINGVLASIQRKLQIQQMHLKDQRIKLMNEVLGGIKVLKLYAWELSFKDKVNEIRTKEMQTLKKYAYLGAVGTFTWTCAPFLVTLASFATYVLLGNN--LDADTAFVSLSLFNILRFPINMMPNMVSYMVTASVSIKRIGRFLATGDIDLKNVLHNS-----RADAPITVENGNFAWGMGEDDLPILKDIDLQVKDNSLTAVVGAVGAGKSSLISAILGEMEKITGFVNVRGTTAYVPQQAWIQNASLRDNILFGKDFDAQKYNKVIEACALGPDLEILPGGDMTEIGEKGINLSGGQKQRVSLARAVYHDCDIYLLDDPLSAVDSHVGKHIFDHVVGPEGLLRKKTRILVTHGVHWLPKVDEVVVILN-GKISEKGSYEELVSHDGAFAQFLKQYLLQEASDN-DESEDE--------ESRRKRHNTLRQTSLLGQKTVEEKDPDKNKDKERLVQDETSEVGRVRIPCRYLTRDTFYMAYCKALGVFMAIFLLLSFLVYQAASVASNIWLSAWTEDSYLKNESLSNTTQYGKRRDMYLGIYGALGIAQAFFVLLYAMVAAVSQVRAAAKLHEYMLHNILRSPMSFFDTTPIGRILNRFSRDIETVDNLLPQLIRSWLNTFFSVVSTIAVISYSTPIFLSVIIPLVIIYYFVQRFYIPTSRQLKRIESTTRSPIYVHFSETVTGASTIRAFDAQHRFINQSEDKVDHNLSFYFASIASNRWLGFRLEFIGALVVASAAIFAVVGKSTLSGGLVGLSISYALQVTSSLNWMVRMTSDLETNIVSVERINEYSETPPEADWYVQRSAPPIS--WPDEGKVAFEDYSTRYRPGMDLVLRGITANIAAGEKVGIVGRTGAGKSSLTMSLFRIIEAAGGSITIDGLNVSHLGLHQLRSKLTILPQDPVLFAGTLRMNLDPFDQYTDDKLWDSLKNAHLSEFIKSLANGLEYECGEGGQNLSVGQRQLVCLARTLLRKTKILILDEATAAVDLETDELIQRTIRQVFASCTILTIAHRLNTIMDNDR 1439
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A1B6E1F3 (Uncharacterized protein OS=Clastoptera arizonana OX=38151 GN=g.30401 PE=4 SV=1) HSP 1 Score: 866.685 bits (2238), Expect = 0.000e+0 Identity = 506/1319 (38.36%), Postives = 789/1319 (59.82%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRS----PNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL--------NESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEEN---------------------YEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S S++T+ W D FK+ ++ + L +TS+E KY E++R P ++ +IG N K+ ++ +LC+ + P FG LK+ +D+L P +L LL+ ++K K+ W+G L A++ ++ F S + +R+R AL IY+K LR+S AR + G+IVN+ +VD ++ M+ Y + S P QI LA+ L+ LG S+ AG+ + +IP+N +I ++ R++ KD+R+ ++ EI G+K++K+YAWE F +++ IRN E+K ++ + S +W PF V +TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + VS RI F+ + E + NS+ S P+ ++NG+FSW +++ L NIN+ V+ L+AVVG VG GKSSL+SA LGEM + G V T+G +AYVPQ+AWIQN T++ NI+ KSF++ Y +++ C L+ D++ LP D+TEIGE+G+NLSGGQKQRVSLARAVY DSD+Y LDDPLSAVD +VG+ +F +I +G+LK KTRVLVTH + +LP VD I V+ D G +SE GTY+ L+ F FL E+ ++D + LI+ + ++K R ++ S N E+ +K + + E+ +G V ++Y K+ G + ++I +++ V NVWL + S++ N T + S+ Y+ Y GLGQ++ +++ G L A++ +H +L +LR+ ++FF+ TP GRILNRF+KD+ +D TL I ++ + ++ ++VVIS +TP F +V IPI I Y +Q FY+++SRQ +RL+S + S + +H E+ G+S IR+ +S F + + +D + +S RWL +RL+ +GNLI+F S +FAVL+R + +A LVGLS+SYALQ+T LNWL R ++ ETN V++ERI++Y P E+ E + ++W + G ++ ++ ++Y L VLK I +NGGEK+G+VGRTGAGKSSL L+LFR++E +G+I IDG++I+S+GLH LR +LTI+PQDPV+FSGTL+ NLDPF + D+ + ++LE S + ++V L+ G+ + G NLS+GQ+QLICL R LL+K+K++ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D D+++ LD G+I+E+ SP LL N S F ++A+
Sbjct: 208 PEVSASFPSKLTFSWFDSLALLGFKQPLEANNLWHLKYEDTSTEVVPLFEKYWSESVRKAANVPQHKASFLKRSGSVDIIGNSTGNTPTKHQAS-ILPALCKAFGPTFLFGSFLKLMQDLLSFVSPQILSLLIAFIKGKES--MWRGYLYAIVLLLAASCQTIFLAQYFFRMSIVGLRIRTALISAIYRKALRMSNSARKESTVGEIVNLMAVDAQRFMDLTAYLNMIWSAPLQIALALFFLWQTLGPSVLAGLAVMIVLIPVNGVIASKAKGLQIRQMKNKDERVKLMNEILSGIKVLKLYAWEPSFEQQVLRIRNKEMKVLKQAAYLNAATSFIWACAPFMVSLVTFAVYVLVDENNVLDAQKAFVSLSLFNILRFPLSMLPMLISNMVQTSVSVKRINKFMNSEELDP---NSVTHDHSEKDPLVMENGTFSWGDSQEDAVILRNINIRVKQGALVAVVGTVGSGKSSLVSAFLGEMDRITGRVNTKGSVAYVPQQAWIQNATMKENIIFGKSFDQNSYNRIVKGCALQQDLDMLPAGDKTEIGEKGINLSGGQKQRVSLARAVYNDSDVYFLDDPLSAVDSHVGKHIFENVIGPKGILKKKTRVLVTHSITFLPEVDLILVMKD-GTVSESGTYKELLAKKGAFSDFLIQHLQEVDEETESELDDLKQQLIESNTELRKKFERQKSTESGSLRQRSNHSESGSVASLNRRRSSSSSEEKVPIEKKPGDKLIEAEKAETGGVKKQVYLYYLKSVGGLLTIATIALNIVYQVFSIGSNVWLSEWSSDTSIIVNGTQDTSKRD--MYLGVYAGFGLGQVVTILVATLTLYLGLLSAARLLHYAVLINILRTPMEFFDVTPVGRILNRFSKDVEAVDQTLPDVIRGWLSCFMSVVATMVVISSITPIFLVVIIPIGIIYFFVQRFYVATSRQLKRLESISRSPIYSHFGESIQGASSIRAYGVQSKFITESEQKVDFNQVCLYPSLISNRWLAVRLETVGNLIIFFSSLFAVLSRDTTNAGLVGLSVSYALQITQTLNWLVRMTSDVETNIVAVERIKEYGETPQEAPWEKSPGPPDDWPNKGQVDFLDYQVRYREGLDLVLKGINFRVNGGEKVGIVGRTGAGKSSLTLSLFRILEAANGQILIDGIDISSLGLHALRSRLTIIPQDPVLFSGTLRMNLDPFGKEKDEDIWRALEHSHLKNFVKGLSAGLQHQVSEGGENLSVGQRQLICLGRALLRKTKVLILDEATAAVDLETDDLIQRTIRTEFKDCTVLTIAHRLNTIMDSDRVVVLDKGAIVEYDSPPNLLKNRSSIFFSMAK 1517 HSP 2 Score: 100.138 bits (248), Expect = 3.256e-17 Identity = 107/434 (24.65%), Postives = 188/434 (43.32%), Query Frame = 2
Query: 2657 IVGIPILICYILLQVFYISSSR--QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNK-FKLIQYL----SLRWLCLRLDILGNLIVFGSVIFAVLNR-FSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLEN--FSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 3910
+ G+ ++I I + S ++ Q R++ +K L + E SG +++ E FE R +K K K YL S W C + +L+ F + N + V LS+ L+ L+ L + +VS++RI ++ + S N ++ + + +EN FS + +L+NI I + G + VVG G+GKSSL A ++ +GR+ G + +PQ I + T+K N+ FD+ + ++++K + LD L G + G G NLS GQKQ + LAR + S + LD+ ++VD + + E + K T +++ H + + + D I+ + DG++ E G+ KELL+ L Q + + E
Sbjct: 455 LAGLAVMIVLIPVNGVIASKAKGLQIRQMKNKDERVKLMN--EILSGIKVLKLYAWEPSFEQQVLRIRNKEMKVLKQAAYLNAATSFIWACAPFMV--SLVTFAVYVLVDENNVLDAQKAFVSLSLFNILRFP--LSMLPMLISNMVQTSVSVKRINKF----MNSEELDPNSVTHDHSEKDPLVMENGTFSWGDSQEDAVILRNINIRVKQGALVAVVGTVGSGKSSLVSAFLGEMDRITGRVNTKG-------------SVAYVPQQAWIQNATMKENIIFGKSFDQNSYNRIVKGCALQQDLD---MLPAGDKTEIGEKGINLSGGQKQRVSLARAVYNDSDVYFLDDPLSAVDSHVGKHIFENVIGPKGILKKKTRVLVTHSITFLPEVDLILVMKDGTVSESGTYKELLAKKGAFSDFLIQHLQEVDEE 862
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A1B6EGY9 (Uncharacterized protein OS=Clastoptera arizonana OX=38151 GN=g.30404 PE=4 SV=1) HSP 1 Score: 866.3 bits (2237), Expect = 0.000e+0 Identity = 506/1319 (38.36%), Postives = 789/1319 (59.82%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRS----PNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW--TEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL--------NESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEEN---------------------YEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S S++T+ W D FK+ ++ + L +TS+E KY E++R P ++ +IG N K+ ++ +LC+ + P FG LK+ +D+L P +L LL+ ++K K+ W+G L A++ ++ F S + +R+R AL IY+K LR+S AR + G+IVN+ +VD ++ M+ Y + S P QI LA+ L+ LG S+ AG+ + +IP+N +I ++ R++ KD+R+ ++ EI G+K++K+YAWE F +++ IRN E+K ++ + S +W PF V +TF ++ N+++ +K FVSL LFN L+ P+ +LP +S + VS RI F+ + E + NS+ S P+ ++NG+FSW +++ L NIN+ V+ L+AVVG VG GKSSL+SA LGEM + G V T+G +AYVPQ+AWIQN T++ NI+ KSF++ Y +++ C L+ D++ LP D+TEIGE+G+NLSGGQKQRVSLARAVY DSD+Y LDDPLSAVD +VG+ +F +I +G+LK KTRVLVTH + +LP VD I V+ D G +SE GTY+ L+ F FL E+ ++D + LI+ + ++K R ++ S N E+ +K + + E+ +G V ++Y K+ G + ++I +++ V NVWL + S++ N T + S+ Y+ Y GLGQ++ +++ G L A++ +H +L +LR+ ++FF+ TP GRILNRF+KD+ +D TL I ++ + ++ ++VVIS +TP F +V IPI I Y +Q FY+++SRQ +RL+S + S + +H E+ G+S IR+ +S F + + +D + +S RWL +RL+ +GNLI+F S +FAVL+R + +A LVGLS+SYALQ+T LNWL R ++ ETN V++ERI++Y P E+ E + ++W + G ++ ++ ++Y L VLK I +NGGEK+G+VGRTGAGKSSL L+LFR++E +G+I IDG++I+S+GLH LR +LTI+PQDPV+FSGTL+ NLDPF + D+ + ++LE S + ++V L+ G+ + G NLS+GQ+QLICL R LL+K+K++ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D D+++ LD G+I+E+ SP LL N S F ++A+
Sbjct: 208 PEVSASFPSKLTFSWFDSLALLGFKQPLEANNLWHLKYEDTSTEVVPLFEKYWSESVRKAANVPQHKASFLKRSGSVDIIGNSTGNTPTKHQAS-ILPALCKAFGPTFLFGSFLKLMQDLLSFVSPQILSLLIAFIKGKES--MWRGYLYAIVLLLAASCQTIFLAQYFFRMSIVGLRIRTALISAIYRKALRMSNSARKESTVGEIVNLMAVDAQRFMDLTAYLNMIWSAPLQIALALFFLWQTLGPSVLAGLAVMIVLIPVNGVIASKAKGLQIRQMKNKDERVKLMNEILSGIKVLKLYAWEPSFEQQVLRIRNKEMKVLKQAAYLNAATSFIWACAPFMVSLVTFAVYVLVDENNVLDAQKAFVSLSLFNILRFPLSMLPMLISNMVQTSVSVKRINKFMNSEELDP---NSVTHDHSEKDPLVMENGTFSWGDSQEDAVILRNINIRVKQGALVAVVGTVGSGKSSLVSAFLGEMDRITGRVNTKGSVAYVPQQAWIQNATMKENIIFGKSFDQNSYNRIVKGCALQQDLDMLPAGDKTEIGEKGINLSGGQKQRVSLARAVYNDSDVYFLDDPLSAVDSHVGKHIFENVIGPKGILKKKTRVLVTHSITFLPEVDLILVMKD-GTVSESGTYKELLAKKGAFSDFLIQHLQEVDEETESELDDLKQQLIESNTELRKKFERQKSTESGSLRQRSNHSESGSVASLNRRRSSSSSEEKVPIEKKPGDKLIEAEKAETGGVKKQVYLYYLKSVGGLLTIATIALNIVYQVFSIGSNVWLSEWSSDTSIIVNGTQDTSKRD--MYLGVYAGFGLGQVVTILVATLTLYLGLLSAARLLHYAVLINILRTPMEFFDVTPVGRILNRFSKDVEAVDQTLPDVIRGWLSCFMSVVATMVVISSITPIFLVVIIPIGIIYFFVQRFYVATSRQLKRLESISRSPIYSHFGESIQGASSIRAYGVQSKFITESEQKVDFNQVCLYPSLISNRWLAVRLETVGNLIIFFSSLFAVLSRDTTNAGLVGLSVSYALQITQTLNWLVRMTSDVETNIVAVERIKEYGETPQEAPWEKSPGPPDDWPNKGQVDFLDYQVRYREGLDLVLKGINFRVNGGEKVGIVGRTGAGKSSLTLSLFRILEAANGQILIDGIDISSLGLHALRSRLTIIPQDPVLFSGTLRMNLDPFGKEKDEDIWRALEHSHLKNFVKGLSAGLQHQVSEGGENLSVGQRQLICLGRALLRKTKVLILDEATAAVDLETDDLIQRTIRTEFKDCTVLTIAHRLNTIMDSDRVVVLDKGAIVEYDSPPNLLKNRSSIFFSMAK 1517 HSP 2 Score: 100.138 bits (248), Expect = 3.574e-17 Identity = 107/434 (24.65%), Postives = 188/434 (43.32%), Query Frame = 2
Query: 2657 IVGIPILICYILLQVFYISSSR--QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNK-FKLIQYL----SLRWLCLRLDILGNLIVFGSVIFAVLNR-FSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLEN--FSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 3910
+ G+ ++I I + S ++ Q R++ +K L + E SG +++ E FE R +K K K YL S W C + +L+ F + N + V LS+ L+ L+ L + +VS++RI ++ + S N ++ + + +EN FS + +L+NI I + G + VVG G+GKSSL A ++ +GR+ G + +PQ I + T+K N+ FD+ + ++++K + LD L G + G G NLS GQKQ + LAR + S + LD+ ++VD + + E + K T +++ H + + + D I+ + DG++ E G+ KELL+ L Q + + E
Sbjct: 455 LAGLAVMIVLIPVNGVIASKAKGLQIRQMKNKDERVKLMN--EILSGIKVLKLYAWEPSFEQQVLRIRNKEMKVLKQAAYLNAATSFIWACAPFMV--SLVTFAVYVLVDENNVLDAQKAFVSLSLFNILRFP--LSMLPMLISNMVQTSVSVKRINKF----MNSEELDPNSVTHDHSEKDPLVMENGTFSWGDSQEDAVILRNINIRVKQGALVAVVGTVGSGKSSLVSAFLGEMDRITGRVNTKG-------------SVAYVPQQAWIQNATMKENIIFGKSFDQNSYNRIVKGCALQQDLD---MLPAGDKTEIGEKGINLSGGQKQRVSLARAVYNDSDVYFLDDPLSAVDSHVGKHIFENVIGPKGILKKKTRVLVTHSITFLPEVDLILVMKDGTVSESGTYKELLAKKGAFSDFLIQHLQEVDEE 862
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A2A3EBU1 (Multidrug resistance-associated protein OS=Apis cerana cerana OX=94128 GN=APICC_09479 PE=4 SV=1) HSP 1 Score: 865.914 bits (2236), Expect = 0.000e+0 Identity = 532/1320 (40.30%), Postives = 805/1320 (60.98%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLI----GKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDG--RPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----------NESSDKVDKNQNNLIQPSAPNK------RKRSRLSTSGSQG--------FDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-----YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYIS-ENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE SS +I + W D ++ FK+ ++ + +N +T+ E K KY K+NL+ N ++++ K G+ NFN E+K V+ LC+ + FG +LK +DI+ P +L+LL++++K + WKG A+L +F +L + F + +R+R AL IY+K LR+S AR + G+IVN+ SVD ++ M+ Y + S P QI+LA+ L+ LG ++ AG+ + +IP+N++I + R++ KD+R+ ++ E+ +G+K++K+YAWE F ++I +IR EIK ++ + S +W PF V ++F ++ N+ + K FVSL LFN L+ P+ +LP + + A VS RI F+ + +E D NN + S + I+NG+F W + RPTL NINL VE +L+AVVG VG GKSSLLSA+LGEM +NG V T+G IAYV Q+AWIQN +L++N+L KS +K Y +V++AC L D++ LP DQTEIGE+G+NLSGGQKQRVSLARAVY DSDIY LDDPLSAVD +VG+ +F +I + GLLK KTR+LVTHG+ +LP VD I V+ D G+I+E GTY+ L++ F FL ES + + + +L N+ R +SR+S S S+ +G+ + K + S + I + S+ W YFK+ G F+ S+I+ IF N WL M +D N+T + + + Y+ YG +GLGQ + L G A++++H ++L V+R+ L FF+ TP+GRI++RF KD+ ++D +L I+D I +I +LVVIS TP F V IPI + Y +Q Y++SSRQ +RL+S + S + +H ET SG+ +IR+ + F + +D + ++ RWL +RL+++GNLI+F + +FAVLN+ ++S+ LVGLS+SYALQVT LNWL R ++ ETN V++ERI++Y P E+ + +Y + W G + +++ ++Y +L VL+ ++ +I GGEK+G+VGRTGAGKSSL LALFR++E G+IFID ++I +GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ YTDD++ ++LE + + ++ +L G+ Y+ G NLS+GQ+QLICLAR LL+K+K++ILDEATASVD ETD + + I+ +F T++ IAHRL TI+D D+II LD+G I+E+ SP+ LL NSS F ++A+
Sbjct: 200 PEQKSSFPGKIFFSWFDSMAWKGFKKPLEITDLWSINPEDTAKEIVPKFEKYWKKNLQKRN------NVQNTKASFRKGSGQVNFNNEYKKKTSSVLPPLCKAFGATFLFGAVLKFIQDIITFVSPQILQLLIDFIKGHEP--LWKGYFYAVLLLITAIFQTLVLSQYFHRMFLVGLRIRTALIAAIYRKALRMSNAARKESTVGEIVNLMSVDAQRFMDLTAYINMIWSAPLQIVLALYFLWDILGPAVLAGLAVLLILIPINVLITNRVKTLQIRQMKHKDERVKLMNEVLNGIKVLKLYAWEPSFEEQILKIRTKEIKVLKETAYLNSGTSFIWSFAPFLVSLVSFATYVLIDENNRLDSTKAFVSLSLFNILRFPLSILPMMIGNMVQAYVSVKRINKFM--NTEELDPNN-VQHDSSESYTLLIENGTFIWDMENIDRPTLRNINLQVEQGQLVAVVGTVGSGKSSLLSALLGEMEKINGRVNTKGSIAYVSQQAWIQNASLQDNVLFGKSLHKNLYNRVIEACALTPDLKVLPAGDQTEIGEKGINLSGGQKQRVSLARAVYNDSDIYFLDDPLSAVDSHVGKHIFENVIGSSGLLKKKTRILVTHGITYLPEVDNIIVLKD-GEITEVGTYKQLLEKRGAFSEFLVQHLQEVHADGESEADLHEIKQHLESTIGSNELQQKLTRGKSRMSESQSESGSIADRKSLNGSLKSNIKEAKLLSPKSGGKLIEVEKTETGSVKWRVYSHYFKSIGWFLSISTIIMNAIFQGFSIGSNTWLSMWSDDNLTDVNNTVDHVKQN--MYLGVYGGLGLGQAMTSFLCDLAPQLGCWLAARQMHIMMLRVVMRAPLTFFDTTPTGRIISRFAKDVDVLDTSLPQQISDSIYCLFEVIATLVVISFSTPIFISVIIPISVIYYFVQRLYVASSRQLKRLESVSRSPIYSHFSETVSGAQMIRAFGVQERFINESESKVDFNQVCYYPSIIANRWLAVRLEMVGNLIIFFAALFAVLNKDTVSSGLVGLSVSYALQVTQTLNWLVRMTSDVETNIVAVERIKEYGETPQEASWKNPDYTPPKEWPVQGRVEFKDYKVRYREDLELVLRGLSFSIKGGEKVGIVGRTGAGKSSLTLALFRIIEAADGQIFIDDIDIAKLGLHDLRSRLTIIPQDPVLFSGSLRINLDPFNCYTDDEVWRALEHAHLKSFIKNLPNGLLYEVSEGGENLSIGQRQLICLARALLRKTKVLILDEATASVDLETDDLIQQTIRQEFKDCTILTIAHRLNTILDSDRIIVLDNGRIVEYDSPESLLRNSSSLFSSIAK 1505
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: K7J1C7 (Uncharacterized protein OS=Nasonia vitripennis OX=7425 PE=4 SV=1) HSP 1 Score: 865.529 bits (2235), Expect = 0.000e+0 Identity = 524/1332 (39.34%), Postives = 787/1332 (59.08%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDG--RPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKV---DKNQNNLIQ-------------------------------------PSAPNKRKRSRLSTSGSQG-----FDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINE-TNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S S++T+ W D ++ FK ++ + +N + + E + KY ++LR + + + + G+ +FN + V+ LC+ + PI FG +LK+ +D++ P +L LL+N+ K+K+ WKG A+L + +L + F + +R+R AL IY+K LR+S AR + G+IVN+ SVD ++ M+ Y + S P QI LA+ L+ LG S+ +G+ + +IP+N ++ R +++ KD+R+ ++ E+ G+K++K+YAWE F ++I +IRN EIK ++ + S +W PF V ++F F+ +++ E FVSL LFN L+ P+ +LP +S + A VS RI F+ + +E D NN + S P+ I+NG+FSW + +P L NINL V+ +L+AVVG VG GKSSL+SA+LGEM L+G V T G IAYV Q+AWIQN TL++NIL K +K Y +V++AC L D + LP DQTEIGE+G+NLSGGQKQRVSLARAVY DSDIY LDDPLSAVD +VG+ +F LI ++GL+K KTR+LVTHG+ +LP VD I V+ D G+I+E GTY+ L++ F FL + +V ++N ++LI+ + N R + ST Q + ++ E+ K + E+ +G V Y ++ G F+ S+I +F NVWL + N TF+ + Y+ YG +GLGQ + V+L + G LR+S +H LL +LRS + FF+ TPSGRILNRF KD+ IID+ L NI + V +I +LVVIS TP F V +P + Y +Q FY+++SRQ +RL+S + S + +H E+ +G+ IR+ + F + +D + ++ RWL +RL+++GNLI+F + +FAVL R ++A VGLSISYALQ+T LNWL R ++ ETN V++ERI++Y P E+ + N + W S G+++ +F ++Y L VL +T ++NGGEK+G+VGRTGAGKSSL LALFR++E G I ID +NI+ +GLH LR +LTI+PQDPV+FSG+L+ NLDPF++ +DD L ++L + + D+V +L G++++ G NLS+GQ+QLICLAR LL+K+K++ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D D++I LD G+I+EF SP LL F ++A+
Sbjct: 205 PEQSASFPSRLTFSWFDALAWRGFKNPLETSDLWSMNPMDMAKEIVPQFDKYWLKSLRKVDNKDHVRAKAMFRKSSGQVDFNNDKNKKSASVLPPLCKAFGPIFMFGVMLKVLQDVMTFVSPQILSLLINFTKHKNQP-MWKGYFYAVLLLLTAILQTLVLSQYFHRMFLVGLRMRTALIAAIYRKALRMSNSARKESTVGEIVNLMSVDAQRFMDVTAYINMIWSAPLQIALALYFLWQILGPSVLSGLAVMIILIPVNALLAGKVRNLQIKQMKNKDERVKLMNEVLSGIKVLKLYAWEPSFEEQILKIRNKEIKVLKEAAYLNAGTSFIWSCAPFLVSLVSFATFVLIDEKNVLNSEIAFVSLSLFNILRFPLSMLPMMISNVVQASVSVKRINKFM--NSEELDPNN-VTHDESEANPLIIENGNFSWDSEHIEKPVLRNINLQVKQGQLVAVVGTVGSGKSSLISALLGEMEKLSGRVNTRGSIAYVSQQAWIQNATLQDNILFGKPLDKALYHRVVEACALTPDFKMLPAGDQTEIGEKGINLSGGQKQRVSLARAVYNDSDIYFLDDPLSAVDSHVGKHIFENLIGSRGLMKKKTRILVTHGITYLPEVDNIVVLKD-GEITECGTYKELLEKRGAFADFLVQHLQEVQTEEENTDDLIEIKQRLENTIGTEELQQRINQARTKVSGSISESGSIGDRKSLNGSLRRQHSTDSQQSGSLLRSNSVKDKEQIQYKTGEKLIETEKAETGSVKWRVYSHYLRSIGWFLSLSTIAMNAVFQSFSIGSNVWLSKWSSDNLTDANGTFDLAGRDQ--YLGVYGALGLGQAIFVLLAQLTMVIGCLRSSYLLHYKLLFGILRSPIGFFDTTPSGRILNRFGKDVDIIDNVLPPNIKAWLFCLVSVIATLVVISYSTPIFISVIVPTGLLYYFIQRFYVATSRQLKRLESVSRSPIYSHFGESVTGAQTIRAYGMQERFIQESEKRVDFNQVCYYPSIIANRWLAIRLEMVGNLIIFFAALFAVLGREDVAAGDVGLSISYALQITQTLNWLVRMTSDVETNIVAVERIKEYGETPQEAAWDIPENDPDKEWPSRGSVDFNDFKVRYREGLDLVLNGLTFSVNGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGEILIDNINISKLGLHTLRSRLTIIPQDPVLFSGSLRLNLDPFNKCSDDDLWRALAHAHLKDFVQTLPNGLSHEVTEGGDNLSVGQRQLICLARALLRKTKVLILDEATAAVDLETDDLIQRTIREEFKECTVLTIAHRLNTILDSDRVIVLDKGAIVEFESPDSLLQKPESAFYSMAK 1529 HSP 2 Score: 96.6709 bits (239), Expect = 4.134e-16 Identity = 140/590 (23.73%), Postives = 247/590 (41.86%), Query Frame = 2
Query: 2234 CVIFGVLQAFGNVWLGMLADTQSLLNNS------TFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNA----TPSGRILNRFTKDLFIIDHTLNLNITDIINR--TVLLITSLVVI---SIVTPWFGIVGIPILICYILLQVFYISSSR--QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNK-FKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 3916
C FG + FG V L +L D + ++ F + +N + Y ++ L + L + ++ + L+ + R L+ N+ + G I+N L +D +++T IN + L +L + I+ P + G+ ++I I + R Q +++ +K L + E SG +++ E FE + +K K K YL S W C L +L+ F + V+ N + + V LS+ L+ L+ L + +VS++RI ++ + E ++ N E+ + I NFS VL+NI + + G+ + VVG G+GKSSL AL +E SGR+ R + + Q I + TL+ N+ P D+ +++++ ++ L G + G G NLS GQKQ + LAR + S I LD+ ++VD + + E + + T I++ H + + + D I+ L DG I E G+ KELL L Q + ++ E++
Sbjct: 301 CKAFGPIFMFG-VMLKVLQDVMTFVSPQILSLLINFTKHKNQPMWKGYFYAVLLLLTAILQTLVLSQYFHRMFLVGLRMRTALIAAIYRKALRMSNSARKESTVGEIVN-----LMSVDAQRFMDVTAYINMIWSAPLQIALALYFLWQILGPSV-LSGLAVMIILIPVNALLAGKVRNLQIKQMKNKDERVKLMN--EVLSGIKVLKLYAWEPSFEEQILKIRNKEIKVLKEAAYLNAGTSFIWSCA--PFLVSLVSFATFVLIDEKNVLNSEIAFVSLSLFNILRFP--LSMLPMMISNVVQASVSVKRINKF--MNSEELDPNNVTHDESEANPLIIENGNFSWDSEHIEKPVLRNINLQVKQGQLVAVVGTVGSGKSSLISALLGEMEKLSGRV-------------NTRGSIAYVSQQAWIQNATLQDNILFGKPLDKALYHRVVEACALTPDF---KMLPAGDQTEIGEKGINLSGGQKQRVSLARAVYNDSDIYFLDDPLSAVDSHVGKHIFENLIGSRGLMKKKTRILVTHGITYLPEVDNIVVLKDGEITECGTYKELLEKRGAFADFLVQHLQEVQTEEE 859
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 833.173 bits (2151), Expect = 0.000e+0 Identity = 502/1311 (38.29%), Postives = 764/1311 (58.28%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKS------------LCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNK------------RKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE +S LS+I++ W+ + Q +K ++++ + LN + S + ++ + K+ + +K + S +IK+ LCR + P I KI D+L+ P +L+LL+ ++ + D +W G L F F +L F + +R+R A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ ITY + S P Q+ILA+ L+ LG S+ AGV + ++P+N +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F K+ IR E++ ++ + I + W PF V TF ++ ++++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL S +E D N+ R ++ A I I +G+FSW+++ RP L IN+ + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDDPLSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL ++ + + + AP K + +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFL--SHEELDENSVDRRAITGSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTDGAPRKTLENGGPAAVLRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1509
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 830.476 bits (2144), Expect = 0.000e+0 Identity = 505/1311 (38.52%), Postives = 764/1311 (58.28%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKS------------LCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSD--------KVDKNQNNLIQPSAPNKRKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE +S LS+I++ W+ + Q +K ++++ + LN + S + ++ + K+ + +K + S +IK+ LCR + P I KI D+L+ P +L+LL+ ++ + D +W G L F F +L F + +R+R A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ ITY + S P Q+ILA+ L+ LG S+ AGV + ++P+N +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F K+ IR E++ ++ + I + W PF V TF ++ ++++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL S +E D N+ R ++ A I I +G+FSW+++ RP L IN+ + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDDPLSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL N D K +K Q N ++ +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFL--SHEELDENSVDRRAITGSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTGKKEKLQRNTTFVHFFPRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1509
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 825.854 bits (2132), Expect = 0.000e+0 Identity = 501/1325 (37.81%), Postives = 765/1325 (57.74%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKS------------LCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ--------------------------PSAPNKRKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE +S LS+I++ W+ + Q +K ++++ + LN + S + ++ + K+ + +K + S +IK+ LCR + P I KI D+L+ P +L+LL+ ++ + D +W G L F F +L F + +R+R A+ G +Y+K L ++ AR + G+IVN+ SVD ++ M+ ITY + S P Q+ILA+ L+ LG S+ AGV + ++P+N +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F K+ IR E++ ++ + I + W PF V TF ++ ++++ +K FVSL LFN L+ P+ +LP +S + A VS R+ FL S +E D N+ R ++ A I I +G+FSW+++ RP L IN+ + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDDPLSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL ++ + + + P+A ++ +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFL--SHEELDENSVDRRAITGSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTEEGGEQEEESGQSEDGAPRKTLENGGPAAVLRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000030862.1 (canalicular multispecific organic anion transporter 1-like [Source:NCBI gene;Acc:103026251]) HSP 1 Score: 812.757 bits (2098), Expect = 0.000e+0 Identity = 516/1363 (37.86%), Postives = 803/1363 (58.91%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPN--------------------------IESEIHDIEDKKCLIGKKNFNE------EFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAX----XXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQ-------------------NNLIQPSAPNK--RKRSRLSTSGSQGFDGNENAEENYEKYFND-----ISHEEEIMSGRVSLNSIVWYFKATGIFVFG-SSILACVIFGVLQAF--GNVWLGMLA-DTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 3910
++PE + LS+IT+ W ++ I+ ++ + E ++L+ ++++ S + + +K+ LR + I ++ + D+ KK+ E E Y ++I S+ + + ++ +LK+ +D+L P +LKLL+ + ++K + +TW+G L A + Q +F CF K+ +RVRAA+ +YKK L LS +AR + G +V + S D ++ + + SCP QI+L++ L++ELG S+ AG+ + ++P+N ++ S+ + + +++KDKRM +L EI G+KI+K+YAWE F +++ R E++ +R + + + ++ P FV +F F+ ++++ EK F S+ LFN L+ P+ +LP +S + VS R+E FL +E+ + ++ R +S + + +++G+FSW DG P L N++L V L+AVVG VG GKSSL+SA+LGEM++L+G+V +G +AYVPQ+AW+QN TLR+N+L ++ + +VL+AC LE D++ LP QTEIGE+G+NLSGGQKQRVSLARAVY +DIYLLDDPLSAVD +VG+ LF K+I +GLLK KTR+LVTHG+ +LP+VDEI V+ D G +SE G+Y L F FL+ + D D+NQ NN+ + + +K S S S N N + E ++ + E + +GRV + + Y + G +G +S+ A V F AF N+WL D N S++ + + YG +G+ Q V + G + AS+ +HS LL +LR+ + FF+ TPSGR++NRF KD+F +D + + +I + + L+ +LV+I + P F V +P++I Y ++ FY+++SRQ RRLDS + S + + ET SG S+IR+ + F ID + K +S RW+ +RL++LGNL+VF S +FAV++R SL + LVGLSISYAL VT LN L R ++ ET+ VS+ER+++Y IP E+ + +E+W S G I +++ ++Y L VL IT +I+ EKIG+VGRTGAGKSSL LFR++E GRI IDG NI S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF++++D+ + K L+++ + ++VNSL G+ ++ G NLS+GQ+QL+CLAR LL+KSKI+ILDEATA+VD ETD + I+ +F TV+ IAHR+ TI+D +++ LD G I+EFG P LL GHF ALA+ K E
Sbjct: 206 KSPEVGAPFLSRITFNWFNRMIFTGYRRPLVQEDMWELSEKDSTNFISREFEEMMKQELRKAHSRLQKKKMKMKKISRPEHQQNGLNKGISQDVLVLVDQSEKSEKKSKRENNLDSGEEDYPHSWLILSIAKTFKWVLLESAVLKLVQDLLSFVSPQLLKLLIGFTQDKSV-FTWRGYLYASLLLIVAIVQSVFLQQFTQRCF----KLGMRVRAAISAAVYKKALTLSNDARKESTIGQMVTLMSADAQRFNEVTNFIHLLWSCPVQIVLSVGFLWIELGPSVLAGLLVMILMVPINGLLAIKSKSYQAKCMMYKDKRMKMLNEILSGIKILKLYAWEPSFEAQVQGFRKQELEVMRKSAFLSSVSTFIFFCAPAFVSLASFAVFVSVSTDNILDAEKAFTSISLFNILRTPLGMLPLLISAMVQMSVSNRRLEKFL---SREDLNTGAVQRDLSYSSAVSVRDGTFSWNRDGSPVLKNVSLQVSPGALVAVVGAVGSGKSSLVSALLGEMHSLSGSVNIKGDVAYVPQQAWVQNATLRDNVLFGSDPDERRFCRVLEACALEPDLDLLPAGVQTEIGEKGINLSGGQKQRVSLARAVYSSADIYLLDDPLSAVDAHVGKHLFEKVIGPRGLLKDKTRILVTHGISFLPYVDEIVVLVD-GVVSEVGSYSSLRASKGAFSEFLDTYAKEEDSQDQNQSASGSQQVSVGVEHHDLPLNNIKTEDSVSLLLKKESVKHASNSNRDSQNRNVPQRSEGDADERKGRRLIESETVQTGRVKFSVYLQYLSSMG---WGYASMFAVVYFIQSLAFIGQNLWLSDWTNDALRYPNGSSYPAHIRDMR--VGAYGGLGVAQGFLVFVGTLLLADGAIHASRTLHSRLLSNILRAPMLFFDTTPSGRVVNRFAKDMFTVDELIPTALRSVILKLLELLATLVLICLAVPLFTAVVVPLIIIYHFVERFYLTTSRQLRRLDSVSRSPIYSLFGETVSGLSVIRAFGHQERFLQQNRTTIDNNLKCVCQLIVSNRWMAIRLELLGNLVVFFSALFAVISRDSLDSGLVGLSISYALNVTLTLNALVRMTSQLETHVVSVERVKEYAEIPNEAAWTSERRPAEDWPSEGTIWFQDYKVRYRPQLDLVLHGITCHIHSKEKIGIVGRTGAGKSSLTNCLFRIIEAADGRILIDGENIASMGLHDLRSRLTIIPQDPVLFSGSLRMNLDPFEKFSDEDIWKVLDLAHLKEYVNSLEAGLQHEIAEGGENLSVGQRQLLCLARALLRKSKILILDEATAAVDLETDDLIQTTIRREFSHCTVLTIAHRINTILDSSRVMVLDAGRIVEFGPPDVLL-QKRGHFYALAKDAGICKTE 1553
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000043850.1 (canalicular multispecific organic anion transporter 1-like [Source:NCBI gene;Acc:103026251]) HSP 1 Score: 812.757 bits (2098), Expect = 0.000e+0 Identity = 516/1363 (37.86%), Postives = 803/1363 (58.91%), Query Frame = 2
Query: 29 ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPN--------------------------IESEIHDIEDKKCLIGKKNFNE------EFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAX----XXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQ-------------------NNLIQPSAPNK--RKRSRLSTSGSQGFDGNENAEENYEKYFND-----ISHEEEIMSGRVSLNSIVWYFKATGIFVFG-SSILACVIFGVLQAF--GNVWLGMLA-DTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 3910
++PE + LS+IT+ W ++ I+ ++ + E ++L+ ++++ S + + +K+ LR + I ++ + D+ KK+ E E Y ++I S+ + + ++ +LK+ +D+L P +LKLL+ + ++K + +TW+G L A + Q +F CF K+ +RVRAA+ +YKK L LS +AR + G +V + S D ++ + + SCP QI+L++ L++ELG S+ AG+ + ++P+N ++ S+ + + +++KDKRM +L EI G+KI+K+YAWE F +++ R E++ +R + + + ++ P FV +F F+ ++++ EK F S+ LFN L+ P+ +LP +S + VS R+E FL +E+ + ++ R +S + + +++G+FSW DG P L N++L V L+AVVG VG GKSSL+SA+LGEM++L+G+V +G +AYVPQ+AW+QN TLR+N+L ++ + +VL+AC LE D++ LP QTEIGE+G+NLSGGQKQRVSLARAVY +DIYLLDDPLSAVD +VG+ LF K+I +GLLK KTR+LVTHG+ +LP+VDEI V+ D G +SE G+Y L F FL+ + D D+NQ NN+ + + +K S S S N N + E ++ + E + +GRV + + Y + G +G +S+ A V F AF N+WL D N S++ + + YG +G+ Q V + G + AS+ +HS LL +LR+ + FF+ TPSGR++NRF KD+F +D + + +I + + L+ +LV+I + P F V +P++I Y ++ FY+++SRQ RRLDS + S + + ET SG S+IR+ + F ID + K +S RW+ +RL++LGNL+VF S +FAV++R SL + LVGLSISYAL VT LN L R ++ ET+ VS+ER+++Y IP E+ + +E+W S G I +++ ++Y L VL IT +I+ EKIG+VGRTGAGKSSL LFR++E GRI IDG NI S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF++++D+ + K L+++ + ++VNSL G+ ++ G NLS+GQ+QL+CLAR LL+KSKI+ILDEATA+VD ETD + I+ +F TV+ IAHR+ TI+D +++ LD G I+EFG P LL GHF ALA+ K E
Sbjct: 211 KSPEVGAPFLSRITFNWFNRMIFTGYRRPLVQEDMWELSEKDSTNFISREFEEMMKQELRKAHSRLQKKKMKMKKISRPEHQQNGLNKGISQDVLVLVDQSEKSEKKSKRENNLDSGEEDYPHSWLILSIAKTFKWVLLESAVLKLVQDLLSFVSPQLLKLLIGFTQDKSV-FTWRGYLYASLLLIVAIVQSVFLQQFTQRCF----KLGMRVRAAISAAVYKKALTLSNDARKESTIGQMVTLMSADAQRFNEVTNFIHLLWSCPVQIVLSVGFLWIELGPSVLAGLLVMILMVPINGLLAIKSKSYQAKCMMYKDKRMKMLNEILSGIKILKLYAWEPSFEAQVQGFRKQELEVMRKSAFLSSVSTFIFFCAPAFVSLASFAVFVSVSTDNILDAEKAFTSISLFNILRTPLGMLPLLISAMVQMSVSNRRLEKFL---SREDLNTGAVQRDLSYSSAVSVRDGTFSWNRDGSPVLKNVSLQVSPGALVAVVGAVGSGKSSLVSALLGEMHSLSGSVNIKGDVAYVPQQAWVQNATLRDNVLFGSDPDERRFCRVLEACALEPDLDLLPAGVQTEIGEKGINLSGGQKQRVSLARAVYSSADIYLLDDPLSAVDAHVGKHLFEKVIGPRGLLKDKTRILVTHGISFLPYVDEIVVLVD-GVVSEVGSYSSLRASKGAFSEFLDTYAKEEDSQDQNQSASGSQQVSVGVEHHDLPLNNIKTEDSVSLLLKKESVKHASNSNRDSQNRNVPQRSEGDADERKGRRLIESETVQTGRVKFSVYLQYLSSMG---WGYASMFAVVYFIQSLAFIGQNLWLSDWTNDALRYPNGSSYPAHIRDMR--VGAYGGLGVAQGFLVFVGTLLLADGAIHASRTLHSRLLSNILRAPMLFFDTTPSGRVVNRFAKDMFTVDELIPTALRSVILKLLELLATLVLICLAVPLFTAVVVPLIIIYHFVERFYLTTSRQLRRLDSVSRSPIYSLFGETVSGLSVIRAFGHQERFLQQNRTTIDNNLKCVCQLIVSNRWMAIRLELLGNLVVFFSALFAVISRDSLDSGLVGLSISYALNVTLTLNALVRMTSQLETHVVSVERVKEYAEIPNEAAWTSERRPAEDWPSEGTIWFQDYKVRYRPQLDLVLHGITCHIHSKEKIGIVGRTGAGKSSLTNCLFRIIEAADGRILIDGENIASMGLHDLRSRLTIIPQDPVLFSGSLRMNLDPFEKFSDEDIWKVLDLAHLKEYVNSLEAGLQHEIAEGGENLSVGQRQLLCLARALLRKSKILILDEATAAVDLETDDLIQTTIRREFSHCTVLTIAHRINTILDSSRVMVLDAGRIVEFGPPDVLL-QKRGHFYALAKDAGICKTE 1558
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16]) HSP 1 Score: 746.888 bits (1927), Expect = 0.000e+0 Identity = 463/1340 (34.55%), Postives = 737/1340 (55.00%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLK-YLKENLR----------SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVD---MEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN----------ESSDKVDKNQNNLIQPSAP-------------------NKRKRSRLSTSGSQGFDGN--------ENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWL-CLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNN-YISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE +S +S++T+ W + ++ +K + L + ++ S + KE R +P ++H E + + +I+++ + P G + K+ +DIL PL+L L+ ++ + TW G +A L F + S+ + F +R+R+AL G++Y+K L ++ AR + G++ + SVD M + N + + W S P I LA+ L+ LG S+ AGV + +IP N I R + + +D+R+ L+E G++IIKMYAWE F I +R E+ + + + + W PF V +F ++ + ++ E+ FVSL LFN L+ P+ LP +S+ A VS R+ NFL E + + + P + + I+ G+F+W+ D P L++I+L V L+AVVG VG GKSSL++A+LGE+ L G+V +G++AYV Q+AWIQN +LR+N+L + ++ +Y +VL AC LE D+ +LP D TEIGE+G+NLSGGQ+QRVSLARA+Y + ++LLDDPLSAVD +VG+ +F ++I GLL +TRVLVTHGL +LP VD I V+ G++SE G+Y LM G F L +S D + +I +P + +R + GSQ G+ E + + + E + +G + L+ ++ Y +A G + S LA ++F G NVWL A N ++ + + + Y +G Q + ++ G LRA+ +H LLD L S + F++ TP GRI+NRF+KD+F+ID L + I ++++I I TP F + IP+++ Y +Q FY+++SRQ +RL+S S V +H E+ +G++ +R+ E F R +D + +S R + + L+ LG +V + +FAVL+R SL A VGLS+SYA+QVT +++W+ R +E E+N V++ER+++Y+ P E+ E + +W S G++ ++S +Y L VL+NI+ +I GGEK+G+VGRTGAGKSSL L L R+VE SG I IDGV+I+ IGLH LR ++TI+PQDPV+F G+L+ NLDPF ++D ++ ++LE + + + +L G+ ++C G N S+GQ+QL CLAR LL+++++++LDEATA+VD ETD + I+ F + TV+ IAHRL T++DC +++ L G I+EF SP LLS F +A+
Sbjct: 190 PEVGASFISRLTFCWFTRMAVNGYRRGLKMSDLWSLRHKDSCSFVVPHLQAVWRKEQARIAQRSAVSQSTPAETRKLHTTEKSQSGGAGTEGGATGQEPS--LIRAMALAFGPRYLVGSVYKLLQDILSFASPLLLSHLIRFVGDNSRP-TWHGYALAGLMFLCAIATSMLAHQHFHAGFVTGIRLRSALTGLLYRKALMITQAARLSCAGGELTTLMSVDVQHMADITNNLNFVW---SAPLHICLAMYFLWQHLGPSVLAGVAVMLLLIPFNAFIALNIRTLQAQIIKKRDERVRTLSEALSGVRIIKMYAWEGRFRDVILRVREHELAVLGRAAYFSMLSAFTWLCSPFLVALASFGVYVLVDEHHVLDAERAFVSLALFNLLRYPLNQLPQLMSELAMASVSLRRLRNFLSLEELDPHAVDRSPSHLRESC-VSIEGGTFTWSWDEPPILHDISLAVPRGCLLAVVGTVGSGKSSLMAALLGELNKLGGSVAVKGQVAYVAQQAWIQN-SLRDNVLFGRPLDETWYREVLQACALEQDLLALPAGDNTEIGEKGINLSGGQRQRVSLARAIYSKASVFLLDDPLSAVDAHVGKHIFERVIGPSGLLAGQTRVLVTHGLSFLPHVDRIVVLT-AGRVSESGSYSELMLSGEAFSELLRIHGQGDGAGEDSPASQDDGPHVIIDLRSPGPDEVLSTCSNIADMEPVMTEPRRMLMRQLGSQEASGSGTTQGVSTETRGHKETQPGSTLMQPESMETGHMKLSVVLHYLRAVGAPL---STLALLLFCANYTTMLGTNVWLSEWA------GEPVVNGTQRNTGYRLGVYSALGAVQSVLSLVMVLMVFKGCLRAAGSLHLALLDNKLHSPISFYDVTPLGRIINRFSKDVFMIDEVLPPTFLMFLGALCNSIFTILIIVISTPVFVVAAIPLVVIYFFVQRFYVATSRQLKRLESTVRSPVFSHFGESVAGAATLRAFRQEERFVIAGDRAVDALQRTSYPSIVSQRRVGAVWLEFLGACVVLFAAMFAVLSRDSLKAGTVGLSVSYAMQVTVVMSWMVRMSSEVESNIVAVERVKEYSETPPEADWEVESCRPPADWPSQGHVEFRDYSTRYREGLDLVLRNISCDIKGGEKVGIVGRTGAGKSSLTLCLLRMVEAASGAIAIDGVDISRIGLHDLRSRITIIPQDPVLFGGSLRDNLDPFGHHSDAEVWEALEFAHLGETARALPGGIQHECAEGGENFSVGQRQLACLARALLRRTRVLVLDEATAAVDVETDALIQGTIRTHFHACTVLTIAHRLHTVLDCTRVMVLSSGQIVEFDSPDVLLSRKDSAFHKMAR 1511
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ABCC8 (ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59]) HSP 1 Score: 544.273 bits (1401), Expect = 1.669e-168 Identity = 374/1212 (30.86%), Postives = 629/1212 (51.90%), Query Frame = 2
Query: 551 VRVRAALCGMIYKKTLRLSTEA--RSIHSAGDIVNMASVDMEQVMNAITYSWIFISCP------FQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFV-PNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNN----SMPRKMS--------------PGAP------------------------IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV--------------------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTR--VLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDK--NQNNLIQPSAPNKRKRSRLSTSGSQ-----GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYI-------NCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETN--NYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 3895
++ RAA+ MIY K L LST + R ++ I N+ +VD Q+M W CP QII+ + LLY LG S G I + PL I + + L R+ +E+ HG+K++K+YAWE+ F +EE R+ E++++ ++ + + + +P + TF +++ P+ ++P F SL LF+ L P+ LL + A+ AL+S ++ FL SE ++ N P+K S P P I++ G F+W L +IN+ + + +L VVG++G GKSSLLSA LGEM+ ++G+V + G +AY Q+ WI N+ ++ NI FN+ Y V++ C L+ DI+ LP D+T+IGE+G+NLS GQ+QR+S+ARA+YQ +++ LDDP +A+D+++ L + I GLL + TR VLVTH L++L D I + D G + GT + + E E +K D+ + +I+ +RK R + + F+ EN + ++F+ +SH ++ G + L Y A+G + +L+ + V A + WL M T LN + N + S+ + + + ++ ++ ++ + GL+A++ +H LL ++R+ L+FF+ TP G ILNRF+ DL +ID + + ++ ++ ++++ VI+ VTP F + +P+ + + +Q + +S+ + LD +L H+MET G + IR+ ES F + ID +N L + RWL +R+D +G IV + + ++ F L + LVGL ++YAL V+ LNW+ R A+ E +I+R+ + +E + + + E+W G I + S +Y+ +L LKN++ I G+K+G+ GRTG+GKSSL+LALFR+++ G I ID V+I+ I L LR +L+I+ QDPV+FSG+++ NLDP TD L +LEI+ + V +L G++ G N S+GQ+QL CLAR ++++ I+I+DEATA++D T++ + + + F TV++IAHR+ I+D D ++ L+ G + E SP LL+N F +L ++++
Sbjct: 384 IKFRAAVQTMIYDKILHLSTSSVSRGKMTSRYISNVVTVDSNQLM------WFLFLCPNLWALPVQIIVGVSLLYSLLGVSALIGAAVIALLAPLQYCIATKLARAQKLTLEHSSSRIKQTSELVHGIKLLKLYAWEQVFCSTVEETRSKELRSLSTFAIYTALSTFMNAAIPITAVMATFVTYVHLSSPDITLSPAVAFASLALFHILVTPLFLLSTVVRFAVKALISMQKLTEFLATSEIGDEPNTLDVEPRPKKSSNADVVQMMAVNRKQPQKPVWDDFEPPQDWRQFEFTDGSEDFAIKVTGGVFTWASSEPSLLTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENITFGSPFNEERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLSAGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGI--LGLLHNDTRTVVLVTHKLQYLTHADWIIAMKD-GTVQREGTLKDIQTSDPELYEMWKELMNKQDEELQKETIIESRTALERKNLRRAMYSKEVLVKTSFEDEENGINS--EHFDSMSH---LLPG-LPLGEWRSYLAASGWPLLLLIVLSQLCKHVSMAAPDFWLAMW--TSRALNVTAQNHNCTSSSVCLCLQSLLASIFAVLCCLAVVMCLISSLAVEWVGLKAARGLHKRLLGRIVRAPLRFFDTTPLGSILNRFSADLHMIDQLIPSSTESLVRSSLFSLSAVSVIAYVTPIFLVALVPLALVHYFIQKHFRIASKDLQELDENTKLPLLLHIMETVDGIATIRAFRHESQFRQRIFELIDANNVPFLFLSAANRWLEVRMDYIGASIVLATAMASITRSFYSGLDSGLVGLGLTYALLVSIYLNWVVRNLADIEVQLQAIKRVNNLMKVEIEDDERSPELHAVPEDWPHRGEIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPGGLDATVREGGENFSLGQRQLFCLARAFVRQTAILIMDEATAALDMATEKILQKVVMTAFADRTVVMIAHRVANILDADVVLVLNQGLLEENDSPANLLANPDTIFSSLVKSNK 1578
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006454.1 (pep scaffold:Pmarinus_7.0:GL483531:32:7621:1 gene:ENSPMAG00000005809.1 transcript:ENSPMAT00000006454.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 353.984 bits (907), Expect = 1.865e-109 Identity = 185/495 (37.37%), Postives = 301/495 (60.81%), Query Frame = 2
Query: 2435 RASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQY-LSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINE-TNNYISEN-----WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAG-KSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 3895
RAS ++H L VLRS++ F+ TP+GR+LNRF++D+ +D + I +L++ L VI+ V PWF + IP+ + ++++ R+ +RLD+ + S ++H+ + G I + +F +Y+ + +N+ L + ++RWL +RLDI+ ++ + + VL + A+ GL+ISYA+Q+TG + R +E E S+ERI+ Y +E++ E +++ E W +G+++ ++ ++Y LP VLK +T NI E +G+VGRTG+G KSSL + LFRLVE C G I IDGV I IGL LR +L+I+PQ+PV+F GT++ NLDP YTD+++ ++LE + M D + L + + + G N S+G++QL+C+AR +L+ SKI++LDEATA++D ETD + E I+ F T++ IAHRL T++ CD+I+ +D G ++EF SP LL N + F A+ A E
Sbjct: 6 RASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVDVRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLH-RYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLMHGQIPAAYAGLAISYAIQLTGTFQFTIRLASETEARFTSVERIQHY----IEALEEEAPDHVPEKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFGDCTMLTIAHRLNTVLSCDRIMVMDQGQVVEFDSPSTLLENRASRFAAMMVAGE 495 HSP 2 Score: 87.8113 bits (216), Expect = 5.244e-18 Identity = 126/491 (25.66%), Postives = 215/491 (43.79%), Query Frame = 2
Query: 548 TVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXX-GYSIFAGVTA--IGAVIPLNI---IIMKFSRKFSERELLFKD-----KRMSILTEIFHGMKIIKMYAWEKCFNKKIEEI--RNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTE------DGRP-TLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTL-NGTVQTEG-------------KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISE 1918
T+R + L ++ K LR S G ++N S DM++V + PFQ L I + L L + A V + AVIPL + II K SR F REL D MS + G+ I Y+ F + +E+ N + + +V W ++V D++ V IT T + + + I +++ L S+ + S RI++++ A E+E + + +P K P A Q+GS S+ + +G P L + N++ ++ + +VGR G G S L L + L G++ +G +++ +PQE + T+R N+ + + L+ ++ +I LP + +TE+ E G N S G++Q + +ARA+ + S I LLD+ +A+D +L + I T + + H L + D I V+ DQGQ+ E
Sbjct: 4 TLRASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVD---------VRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFI-RELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLHRYQELLDTNQACLFLFSCAVRW--LAVRLDIIS--VALITTTALMMVLMHGQIPAAYAGLAISYAIQLTGTFQFTIRLASETEARFTSVERIQHYIEALEEE--APDHVPEK--PLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTET-DTLIQETIRRA--FGDCTMLTIAHRLNTVLSCDRIMVM-DQGQVVE 472
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007076.1 (pep scaffold:Pmarinus_7.0:GL480539:10051:22495:1 gene:ENSPMAG00000006379.1 transcript:ENSPMAT00000007076.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 346.28 bits (887), Expect = 4.305e-106 Identity = 193/523 (36.90%), Postives = 305/523 (58.32%), Query Frame = 2
Query: 2303 LLNNSTFNQSRNSA---KFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSN 3856
LL + + S N + +FY++ YG + G + +L F +GG+ A+K IH LL VL++ + FF+ATP+GRI+NRF+ DLF +D +L + + + L+ ++VV+ PW +V +P+ Y +Q +Y +SR+ +RL S S + +H E+ SG +II++ A F ++ + + + + WL +RL ++G +IV AVL + LVGL+I+YAL + G L+ L + ET VS+ER+++Y I E + ++S +W G + + L Y LP L I+ IN EK+G+VGRTG+GKS+L LFR+V+ G I+ID +I+ + L QLR L I+PQDP +FS T++ NLDP Y D +L + LE + +V G+ + G + S GQ+QL+CLAR +L K+KI+ +DEATASVD++TD + + I+ +FV+STV+ IAHR TI+D D+++ L G ++EF SP +LL +
Sbjct: 2 LLLSPPYRSSANGSDPVQFYLSVYGALAAGNTVFTLLRAFLFAYGGVCAAKNIHVTLLHKVLQAPVSFFDATPTGRIMNRFSSDLFTVDDSLPFIMNIFMAQLFGLVGAIVVMCYGLPWMALVLLPLAGVYYCVQKYYRFTSRELKRLGSVTLSPIYSHFAESLSGLAIIKAFRATDRFTRENEARLELNQRCQFAAVAVMHWLDVRLQMMGVVIVVSLAALAVLEHHLRGVDPGLVGLAIAYALGINGRLSGLVSSFTQTETQMVSVERVQEYRGIASEEAHRHPTHVSPDWPQGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLD-QGGLQAEVAERGRDFSCGQRQLLCLARAMLFKAKILCIDEATASVDQDTDVLLQKTIRSEFVNSTVLTIAHRPNTILDSDRVLVLQGGRVLEFASPHDLLQD 523 HSP 2 Score: 76.2554 bits (186), Expect = 2.318e-14 Identity = 77/291 (26.46%), Postives = 137/291 (47.08%), Query Frame = 2
Query: 1184 SQAISALVSFGRIENFL-LASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTE------DGRP-TLNNINLNVENQKLIAVVGRVGVGKSSLLSAIL-------GEMYTLNGTV------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLE---YDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGL------LKHKT-------RVLVTHGLKWLPFVDEICVIND-QGQISERGTYEHLM 1942
+Q + +VS R++ + +ASE+ + P +SP P Q G+ ++ + G P LN I+ + + + + +VGR G GKS+L S + G +Y N + Q +A +PQ+ ++ ++T+RNN+ S+ +VL+ C L+ D L Q E+ ERG + S GQ+Q + LARA+ + I +D+ ++VD + L K I ++ + + H+ RVLV G + L F ++ D + +S + HL+
Sbjct: 260 TQTETQMVSVERVQEYRGIASEEAHRH----PTHVSPDWP---QGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLDQGGL----QAEVAERGRDFSCGQRQLLCLARAMLFKAKILCIDEATASVDQDT-DVLLQKTIRSEFVNSTVLTIAHRPNTILDSDRVLVLQGGRVLEFASPHDLLQDPRSALSRLLSKSHLL 538
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001536.1 (pep scaffold:Pmarinus_7.0:GL479104:2125:31869:1 gene:ENSPMAG00000001392.1 transcript:ENSPMAT00000001536.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 323.553 bits (828), Expect = 4.132e-98 Identity = 172/491 (35.03%), Postives = 292/491 (59.47%), Query Frame = 2
Query: 2435 RASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINE--TNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 3895
+ ++ +H+ +L ++ + +++F+ TP G ILNRF+ D I+D + + ++ +L +++L +I+ VTP F I +P+ I Y +Q ++ +SR + LD + +H ET G + IR+ E F D +N L + RWL +RLD +G IV + + ++ + + +LS++ VGL ++YAL V+ LNW+ R A+ E +I+R+ I ES + + + +NW +G I +E S++Y+ L VLK++ +I +K+G+ GRTG+GKSSL+LA FR+V+ GRI ID ++I I LH LR +L+I+ QDP++FSG+++ NLDP D L ++L+I+ + V +L G++ G N S+GQ+QL CLAR ++K+ I I+DEATAS+D T+ + + + F + TV+IIAHR+ TI+ D ++ L GS++E+ +P LL++ S F + +AD+
Sbjct: 30 KTARNVHNNMLKRIVLAPMRYFDTTPLGHILNRFSADTNIMDQQIPTTLESLMRSALLCLSALGIIAYVTPIFLIALVPLAIAYYFIQKYFRVASRDLQELDDSTQLPLFSHFSETVEGITTIRAFRHEVRFRQRLLELTDANNISYLFLSAANRWLEVRLDYIGACIVLIASVASITDSWNNTLSSARVGLCLTYALMVSNYLNWVVRNLADIEVQMGAIKRVNNLLQIETESYDGLLSQAQVPDNWPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDMATESILQKVVMTAFANRTVVIIAHRVHTILTADLVMVLKRGSVLEYDTPSTLLAHDS-MFASFVRADK 519 HSP 2 Score: 78.1814 bits (191), Expect = 6.046e-15 Identity = 62/268 (23.13%), Postives = 123/268 (45.90%), Query Frame = 2
Query: 1217 RIENFLLASEKEND---SNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEG-KIAYVP------------QEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL 1972
R+ N L + D S +P I+I+ S + +P L ++N +++ + + + GR G GKSSL A + T G + + IA +P Q+ + + ++R N+ + + LD L++ +++LP + E G N S GQ+Q LARA + + I+++D+ +++D+ +S+ K++ ++T V++ H + + D + V+ +G + E T L+ + F SF+
Sbjct: 252 RVNNLLQIETESYDGLLSQAQVPDNWPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATESILQKVVMTA--FANRTVVIIAHRVHTILTADLVMVLK-RGSVLEYDTPSTLLAHDSMFASFV 515
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YCF1 (Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]) HSP 1 Score: 701.049 bits (1808), Expect = 0.000e+0 Identity = 461/1327 (34.74%), Postives = 728/1327 (54.86%), Query Frame = 2
Query: 32 NPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLR---SPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRND-EIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPG-APIEI-QNGSFSWTE--DGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEH------------LMDFGTEFKSFLNESSDKVDKNQNNLIQP------------------SAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXX-XXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV--LNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLT-EGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 3880
NP + +++ S+IT+ WM + +++ + + + L +S E S+K K + L+ +P++ I K L+ F + F L R+ ++K D L + +G L+A F G + + F + +++AL +IY+K+L LS EA + S GDIVN+ SVD++++ + + + S PFQII+ + LY LG S++ GV + ++PLN +M+ +K + ++ +KD+R +++EI + +K +K+YAWEK + +K+EE+RN+ E+KN+ + + S +++VPF V TF F+Y + +T + +F +L LFN L P++++P L+ I A VS GR+ F E + DS +P+ + G I I + +F W + + L NIN + L +VG+VG GK++LLS +LG+++ + G G +AYV Q WI N T++ NIL ++ FY K + AC L D+ L + D+T +GE+G++LSGGQK R+SLARAVY +D YLLDDPL+AVD +V + L ++ GLL KT+VL T+ + L D I ++ D G+I+++GTY+ L ++G + NE D + + P S +R+ +T GS F +EN I+ E G+V N + Y KA IL VI L GNVWL ++ NS + + N+A+ Y+ Y +G+G LA ++ +F + ASK +H+++ ++VLR+ + FF TP GRILNRF+ D++ +D L + V + ++ VI T F + IP+ + YI Q +Y+ +SR+ RRLDS S + +H ET G + +R + F I ID + + RWL RL+++G++I+ G+ +V L + +L+A +VGLS+SYALQ+T LNW+ R E ETN VS+ERI++Y + E+ I E + E W S G+I N+S +Y L VLK+I I+I EK+G+VGRTGAGKSSL LALFR++E G I ID + IN IGL+ LR +L+I+PQD +F GT++ N+DP ++YTD+ + ++LE+S + + V S++ +G++ G NLS+GQ+QL+CLAR +L SKI++LDEATA+VD ETD+ V E I+ F T++ IAHRL TI+D D+II LD+G + EF SP +LLS++ F +L
Sbjct: 210 NPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENELKQKSNPSLSWAICRTFGSKMLLAA--FFKAIHDVLAFTQPQLLRI---------LIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVPFLVSCCTFAVFVY-TEDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINIGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALL-DNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAISLRRASDATLGSIDFGDDEN-----------IAKREHREQGKVKWNIYLEYAKACNPKSVCVFILFIVISMFLSVMGNVWLKHWSEV-----NSRYGSNPNAAR-YLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKE-WPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSL 1505
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YBT1 (Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication [Source:SGD;Acc:S000003971]) HSP 1 Score: 605.52 bits (1560), Expect = 0.000e+0 Identity = 404/1236 (32.69%), Postives = 639/1236 (51.70%), Query Frame = 2
Query: 512 CENYCFAITSKITVRVRAALCGMIYKKTLR--LST-----------------------EARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSP-GAPIEIQNGSFSWTEDGRP-TLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV----------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND-------------ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVW---------------------LGMLADTQSLLNN----------STFNQ--SRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNM----------------------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
C+ ++ +R+++ + IY K LR +ST E+ S + G I+N+ ++D +V Y F+ ++A+ LLY LG++ GV I A++PLN + K+ ++ L D R+ L E F ++IIK ++WE+ F K I IR +E+ + S+ W I S LW + P V +F ++IY L TP F +L LF L+ P+ L LS + + VS R+++FL END+ + P G +N + SW +D + L ++N+ + KL V+G G GK+SLL A+LGEMY LNG V T IAY Q AW+ N+T++NNIL FN+ Y V++AC L+ D E L D TEIGE+G+ LSGGQKQRVSLARA+Y ++ LLDD LSAVD + +++ I+ L++ +T +LV+H + E+ V+ + G++ ++G ++ G + L +SS + N+ +A + S L Q N N+ K + EE G V L+ WY K G + S + + + L G W + ++ S L + S NQ S +S +Y+ Y IIG Q L G+ AS+KI +++L+ VL S ++FF+ATP+GRI+NRF+KD+ ID L I + ++++++I+ +TP F V I + I Y + FY++ SR+ +R +S + S + H ET G + IR+ E F ID++NK +++ RWL R+D++G+L++FG+ +F + N +L + + G+S++YA+ T WL R +E E N S+ER+++Y I E NE W +G I + + SL+Y NLP V+KN++ +++ KIG+VGRTGAGKS++ ALFR +E +G I ID ++I+ + L +LRR +TI+PQDP +FSGT+K NLDP+DE++D ++ ++L+ ++ L +G + N G+NLS GQ+QL+CLAR+LL+ KII+LDEATAS+D +D ++ E I+ +F ST++ IAHRL+++ID DKI+ +D G + E+ P LL N F ++ +
Sbjct: 410 CQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVA-FTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFL----NENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGP-LMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGLFGEDELVKSS--ILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLIS-EEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCE 1636 HSP 2 Score: 74.3294 bits (181), Expect = 1.134e-13 Identity = 103/479 (21.50%), Postives = 203/479 (42.38%), Query Frame = 2
Query: 2516 GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRW-----LCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGN-INLENFSLQYNI-NLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINS---IGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIE-AIKFQFVSS-TVIIIAHRLK-TIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIK 3904
G I+N D F + + + V+ + +L ++ + + IVG+ I++ + L ++ + + + L E + II+ E +FE + N + N+ L+ S+ W L + F I+ + + LS+ L+ L+ L+ + + VS++R++ + + N+T Y NGN EN ++ ++ N LK++ I G+ V+G TG+GK+SL +AL + +G++ + + + + + Q + + T+K N+ PF+E + +E G+ L G + G G LS GQKQ + LAR L ++ ++LD+ ++VD T + + I + T I+++H + T+ + + ++ L+DG + + G P ++L K L DE +K
Sbjct: 476 GAIINLMAIDAFKVSEICGY-LHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFE--KDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLR--DPLDRLSDMLSFVVQSKVSLDRVQDFL-----NENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNE---ARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQ------KGLFGEDELVK 935
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: BPT1 (ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938]) HSP 1 Score: 597.045 bits (1538), Expect = 0.000e+0 Identity = 409/1213 (33.72%), Postives = 649/1213 (53.50%), Query Frame = 2
Query: 557 VRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRND-EIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA------PIEIQNGSFSWTE----------------------DGRPTLNNIN-LNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQT--------EGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNK-LISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFG---TEFKSFLNESSDKVDKNQNNLIQPSAPNKR--------------------------------KRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQL-LAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLN---RFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE--SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLT------EGMNYDCGNM-----------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIK 3904
+R +L ++Y+K+LRL+ R+ S GDI+N+ SVD+ ++ + I P QII+ + LY LG ++ G+ + ++P+N + + +K S+ ++ +KD R+ +TE+ + +K IK+YAWE+ ++ +RND E+KN R + + ++ W+ VP V TF F F +S ++P +F SL LFN L I +P ++ I VS R+++FLL+ E ++ S ++ P A IE+ N +F W + L NI+ + L+ VVGRVG GKS+ L AILG++ ++G+ + +AY QE+WI N ++R NIL F++ +Y + AC L D++ LP+ D+T +GE+G++LSGGQK R+SLARAVY +DIYLLDD LSAVD V +++ LI LLK+KT +L T+ + L I + + G+I E+G YE +M+ ++ K L E +D + +Q ++ +R+ L+T + F G A+ + K + + E+ GRV + Y KA G+ L ++ V N WL +++ N S ++ Y +IG+ + ++ +R SKK+H + +V+RS + FF TP GRI+NRF+ D+ +D L + + + +++++ PWF + + +++ YI Q FYI SR+ +RL S + S +++ + E+ +G SII + + F + Y I + F + RWL +RL +G IV + I A+ + LS+ +VGL +SY+L+VTG L W+ R ETN VS+ERI +Y +P E SIN ENW S G I +N+S +Y NL VL NI + I EK+G+VGRTGAGKS+L+LALFR++E G+I IDG++I+ IGL LR L I+PQD F GT+K NLDPF+ Y++D+L +++E + + + + + N + GN+ G+NLS+GQ+QL+CLAR LL +SKI++LDEATASVD ETD+ + + I+ +F T++ IAHR+ T++D DKII LD GS+ EF SP +LLS+ + F +L + Y+K
Sbjct: 365 IRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLFSLF-SDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDD----SFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYAL-ENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVG---AQLDSVKKTAQKAEKTEV--GRVKTKIYLAYIKACGVLGVVLFFLFMILTRVFDLAENFWLKYWSESNEK------NGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKR-PDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEKGGYLK 1559
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: VMR1 (Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication [Source:SGD;Acc:S000001027]) HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0 Identity = 397/1199 (33.11%), Postives = 641/1199 (53.46%), Query Frame = 2
Query: 512 CENYCFAITSKITVRVRAALCGMIYKKTLR--------LSTEARSIHS-AGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPT----LNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEG---KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLS-TSGSQGFDGNENAEENYEKYFND--ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWL---------------GMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISEN-----------WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSL------------EISGMLDWVNSLTE---GMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
C + ++ KI +R+RA L G IY K LR S+++ SI + G I+N+ S+D +V Y ++ + II+ + LL+ LG S FAG++ I + PLN ++ KF ++ L D+R+S L E ++I+K +AWE+ +I+ IR E++++ S+ W + S LW + P V +TF + L P F +L LF L+ P+ L LS + VS RI +FL + +D+ +SP IE +N + +W E+ L +N+ + KL ++G G GKS+LL +LGE+ ++G++ EG AY Q AW+ N+T++NNI+ +N+ Y KV+DAC L+ D+E LP D TEIGE+G+ LSGGQKQR+SLARAVY + LLDD LSAVD + ++ I+ L+K++T +LVTH + ++ + G++ +GT L G FK + S + N+ N + AP K ++ + + FD N + ND + EEE +G +S + WY K G F +++ A I + W G DT L + ++++++A +Y+ Y +IG+ Q + G+RAS+KI + LLD VL + ++FF+ TP GRI+NRF+KD+ +D L + I + + + +I+++TP F V + + + Y + +Y+++SR+ +RLDS S + H ET G IR+ E F ID++N+ ++++W R+D++G IV S F +LN ++ + L G+S++YA+ T WL R + FE N S+ER+++Y+ I E NY+ + W +G I +EN SL+Y NLP V++N++ ++ KIG+VGRTGAGKS++ ALFRL+E +G I IDG +I+ I L LRR +TI+PQDP++F+GT+K N+DP+DEY + K+ K+L E+ + NS ++ + G NLS G++QL+ +AR+LL++ KII+LDEAT+S+D ++D + I+ +F ST++ IAHRL+++ID D+II +D G + E+ P ELL + G F ++ +
Sbjct: 396 CNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLA-FTTLSLFTLLKTPLDQLSNMLSFINQSKVSLKRISDFL----RMDDTEKYNQLTISPDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGP-LMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGL-FKEKYVQLSSRDSINEKNANRLKAPRKNDSQKIEPVTENINFDAN---------FVNDGQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSI------EQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSMCR 1572
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YOR1 (Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513]) HSP 1 Score: 502.286 bits (1292), Expect = 4.633e-154 Identity = 351/1113 (31.54%), Postives = 566/1113 (50.85%), Query Frame = 2
Query: 860 LFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPG----APIEIQNGSFSWTED-----------------------------GRPT-----------------------------LNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL---NESSDKVDKNQNNLIQPSAPN-------------KRKRSRLSTSGSQG---FDGNENAEENYEKYFNDIS---HEEEIMS--GRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRN-SAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQY-TMIPVE-SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGM-----LDWVNSLTEGMNYDCGNM------------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 3880
+F D R++++ E+ + +K+IK Y WE + K I++IR EI +R + + + + +P +TF +Y V P IF SL LF L L + LP + I ++ GR+++ L A E +D N + K SPG +++ + SF W ED G+P+ ++N +++ + I + G +G GKSSLL+A+ G M +G V+ G + WIQN ++R+NI+ FNK Y +V+ C L+ D++ LP D TEIGERG+ LSGGQK R++LAR+VY+ DIYL DD LSAVD VG+ + ++ ++ G+L +KTR+L TH L + + V+ GQ+ + GT + L + L +++S+K D+ Q ++ K+K + +S + + G DG+ +++E E+ N IS + E I + G+ ++ Y I V G++ + F +VWL + N+ +N FY+ Y + + + G+ ASK ++ + +L + + + + TP GRILNRFTKD +D+ L ++ + ++ ++ V+ + PWF I +L+ ++L+ Y SS R+ +RL++ SFV +L E G I++ ++ F + I+K N+ + + RW+ + LD++ + V F +SA+ VG+ ++Y LQ+ G+LN + R + E + S ER+ Y T +P+E S + E+W S G I EN Y LP VLKN+ +NI GEKIG+ GRTGAGKS++ AL+RL E +G+I ID V+I+ +GL LRR+L I+PQDPV+F GT+++NLDPF+E TDD+L +L G L V N G M G+N S+G++QL+ L R L+++SKI+ILDEAT+SVD ETD ++ I +F T++ IAHRLKTI++ D+I+ L+ G + EF +P L S F+++
Sbjct: 382 IFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTF-LAMYKVNKGGRQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPE--DDPNQMIEMKPSPGFDPKLALKMTHCSFEW-EDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLT--GMLANKTRILATHQLSLIERASRVIVLGTDGQV-DIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKE--ERAVNSISLKIYREYIKAAVGKWGFIALPLY----AILVVGTTFCSL--------FSSVWLSYWTE----------NKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSM 1462
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO36474 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SII0]) HSP 1 Score: 835.099 bits (2156), Expect = 0.000e+0 Identity = 492/1232 (39.94%), Postives = 746/1232 (60.55%), Query Frame = 2
Query: 308 VIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASE-KENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN------ESSD-------KVDKNQNNLI--------------QPSAPNKRKRSRLS---------TSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
++K L +++P F K+ +D ++ L L + S +W+G + AL+ F F S+ + F I ++++ AL G+IY K LRL++ +R+ +AGD+VN+ SVD ++V++ TY + S P QI++A+ LY +G+SI AGV + +IP N+++ +FSRK +++ KD R+ I+ EI +GMK++K+YAWE+ F K+ IRN E+ +++N + PF V TF IY + +++T FV++ LFN L+ P+ +LP + + A VS R+ FL E E + + MP +S A I + +GSFSW G+PTL+NINLN+ + L+AVVG+VG GKS+LLSA+LGE + G V +G +AYVPQ+AWIQN TLR+N++ ++F+ Y K + C LE D + LP D TEIGERG+NLSGGQKQRV+LARAVY ++D+YLLDDPLSAVD +VG+ +F+K+I +G L+ KTRVLVTHG+ +LP VD+I V+ D G++SE GTY+ L+ F FL +S D +V +++ +++ +P R+R R + TS + D EE+ E + + EE+ +G V Y K+ G+F+ IL ++ +WL + +N T + +R+ Y+ Y G Q V++ FG +RAS+ IH LL + + + FF TP GR++NRF+KDL+++D T+ + + + + I +L I+ TP F V IP+ I Y+L+Q Y++SSRQ +R++S + S + + ET SG+S IR+ + F Y +D++ +S RWL LRL+ +GNLI+F + +FAV+ R S+ ++LVG+SI+YALQ+T LN + RQ +E ETN VS+ER ++Y + E+ + E ++ + W G I +E+F L+Y NLP VLKNI+++I GEKIG+VGRTGAGKS+L LALFR++E GRI +D ++I+ +GL LR LTI+PQDPV+FSGTL+ NLDPFD Y+D+ L + LE+S + + + L EG+ + G NLS+GQ+QL+CLAR LL+KSK+++LDEATA+VD ETD + I+ +F TV IAHRL TI+D +I+ LD G ++EF SP+ L++ G F +AQ
Sbjct: 4 LMKVLFLIFWPQFFLAAFFKLIQD--SMSFVQPTILRLMISFVEGNSPSWEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQLKQMANKDSRIRIMNEILNGMKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFTFTCAPFLVSLATFA--IYVLTGNILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHISNQA-IHVDDGSFSWDVTGQPTLHNINLNIPDGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQD-GRVSEVGTYKELLANRGAFAEFLKTFAPEEKSGDAALKVLREVPEDEEDILVRLQAIGDEDEMFMEPEPQPIRRRGRANSVVTIGTTITSDTADTDCMTIMEEDRE--VDHMIGEEKAATGSVKWVVFWAYAKSIGVFIASIVILFMILSEGALVGSRIWLAAWS-----ADNDTSDATRD---MYLGGYAAFGFFQAFFVLVSSICLAFGSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVE-DSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISKMGLQDLRSSLTIIPQDPVLFSGTLRFNLDPFDAYSDEDLWEVLEVSHLKAFASGLPEGLLHPIAEGGENLSVGQRQLVCLARALLRKSKVLVLDEATAAVDLETDELIQNTIRTEFAERTVFTIAHRLNTIMDYSRILVLDKGFMMEFDSPQNLIAQ-RGIFYGMAQ 1217
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO35071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMJ8]) HSP 1 Score: 644.425 bits (1661), Expect = 0.000e+0 Identity = 398/1045 (38.09%), Postives = 608/1045 (58.18%), Query Frame = 2
Query: 446 SYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMS----ILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASE-KENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLST-----------SGSQG--------FDGNENAEENYE---------KYFNDISHEEEIMSGRVSLNSIVW---------------YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQ 3430
S +W+G + AL+ F F S+ + F I ++++ AL G+IY K LRL++ +R+ +AGD+VN+ SVD ++V++ TY + S P QI++A+ LY +G+SI AGV + +IP N+++ +FSRK + + + ++ K++K+YAWE+ F K+ IRN E+ +++N + PF V TF IY + +++T FV++ LFN L+ P+ +LP + + A VS R+ FL E E + + MP +S A I + +GSFSW G+PTL+NINLN+ L+AVVG+VG GKS+LLSA+LGE + G V +G +AYVPQ+AWIQN TLR+N++ ++F+ Y K + C LE D + LP D TEIGERG+NLSGGQKQRV+LARAVY ++D+YLLDDPLSAVD +VG+ +F+K+I +G L+ KTRVLVTHG+ +LP VD+I V+ D G++SE GTY+ L+ F FL + + Q S P+ + +R+ + SQG E+ +N + +YF S ++ + ++SI W Y K+ G+F+ IL ++ +WL + +N T + +R+ Y+ Y G Q V++ FG +RAS+ IH LL + + + FF TP GR++NRF+KDL+++D T+ + + + + I +L I+ TP F V IP+ I Y+L+Q Y++SSRQ +R++S + S + + ET SG+S IR+ + F Y +D++ +S RWL LRL+ +GNLI+F + +FAV+ R S+ ++LVG+SI+YALQ+T LN + RQ +E ETN VS+ER ++Y + E+ + E ++ + W G I +E+F L+Y NLP VLKNI+++I GEKIG+VGRTGAGKS+L LALFR++E GRI +D ++I+ +GL LR LTI+PQ
Sbjct: 13 SPSWEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQVCQFILIGVSLCQPPLCRCCLWGSCKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFTFTCAPFLVSLATFA--IYVLTGNILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHISNQA-IHVDDGSFSWDVTGQPTLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQD-GRVSEVGTYKELLANRGAFAEFLKTFAPEEKSGDAAREQESCPDNSQGARVMSRQIAREQESCPDNSQGTRVMSRQIAREQESCPDNSQGTRRKTLRSRYFT--SKVAQLRHAK-PMDSITWSPYISFQVKWVVFWTYAKSIGVFIASIVILFMILSEGALVGSRIWLAAWSA-----DNDTSDATRD---MYLGGYAAFGFFQAFFVLVSSICLAFGSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVE-DSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISRMGLQDLRSSLTIIPQ 1041 HSP 2 Score: 103.99 bits (258), Expect = 2.109e-22 Identity = 68/262 (25.95%), Postives = 134/262 (51.15%), Query Frame = 2
Query: 3083 VSIERIRQYTMIPVESINETNNYIS-ENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSN 3856
VS++R+ ++ + ++ ++ETN + + +SN I++++ S +++ L NI +NI G + VVG+ G GKS+L AL E +G +++ G + +PQ I + TL+ N+ + + K++++ + + L G + G G NLS GQKQ + LAR + + + +LD+ ++VD + + + + + + T +++ H + + D+I+ L DG + E G+ KELL+N
Sbjct: 268 VSLKRLTKF--LTLDELDETNVHKKMPSHISNQAIHVDDGSFSWDVTGQPTLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKG-------------SVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQDGRVSEVGTYKELLAN 514
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO41257 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4U1]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 387/1160 (33.36%), Postives = 627/1160 (54.05%), Query Frame = 2
Query: 518 NYCFAITSKI-TVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWI--------FISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFT-FFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAIS-ALVSFGRIENFLLASEKENDS-NNSMPRKMSPGAPIEIQNGSFSWTED-GRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFN-----DISHEEEIMSGRVSLNSIVWYFKA-----TGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLN---------NSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLR-WLCLRLDILGNLIVFGSVIFAVLN----RFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
N FA + +RVRAA +IYKK L LS A + + G+++N+ S D ++ + W+ I P ++ + +LL+ ++G + AGV + + P+ + + + + + D+R+ I+ EI GM++IKMY WE F K I +R +E+K ++ I I FT F +Y + ++T K+F + LFN++++ L + + VS R E LL E ++ S R + + ++ S +W ++ PTL+ ++ +V + L+ V+G VG GKSSLL+AILGE+ G+++ +G++AY Q+AW+ N+TLR+NIL K +++ Y V+ AC L+ D E L D+T +GERGV+LSGGQ+ R+SLARAVY D DIYLLDDPLSAVD NVG+ LF + I LK K R+LVTH L++L DEI V+ QGQ ++GTY+ L + F S L E ++ N+++ S R S+ + N ++ + + EE G VS + Y ++ TG+F+ + C + V+ FG+VWL A+ + + + ++T + SR +Y++ Y + G + ++ + + + AS+ +H+ + +++ + + FF+ GRILNRF+KD+ +ID + + D++ + + +++ P + +P++ + + +++ SSR+ +R++ S + H T G IR+ E+ F Q+ ++ YL+ + WL RL LG +VF ++F VL + LSA VGL +SY++ + + + AE E S+ER+ +YT +P E T+ +W G I +N S Y+ +LP VL N+T I EK+GVVGRTGAGKSSL LFRL E G I IDG+NI +GL LR +L+I+PQDPV+FSGT+++NLDPF E+ D L K L+ + V L ++ + G+N S+GQ+QL+CLAR +L+ S+I+++DEATA+VD TD + E I+ +F TV+ IAHRL TI+D D+++ LD G ++EF +P +LL + F L +
Sbjct: 126 NVPFAFMKNVYGMRVRAACTALIYKKVLHLSRTALASTTTGNLINLVSADAQK------FDWVRLAPFLHYLILGPLEVGVVAVLLWYQIGPAALAGVGLLVCLAPMQVKMGNALMSLRGKAIHWMDERVKIMNEIIAGMRVIKMYTWEDSFAKLIMHLRKNELKWFLRMAY---IQGAFASFFFSSAGLIYFTTFLVYVLTGEVLTAAKVFTCVSLFNSVRIVCALFFPFAITLFNESRVSLKRFEEALLLDEMHSEGLVKSTLRPKAEECGVFVKKASATWNKEIAIPTLDGLSFDVPSGCLLGVIGAVGSGKSSLLNAILGELPLSEGSIRVQGRVAYASQQAWVYNSTLRHNILFGKEYDEHRYNDVIKACALDKDFELLSEGDETLVGERGVSLSGGQRARISLARAVYADGDIYLLDDPLSAVDANVGRHLFQECICTY--LKDKARILVTHQLQFLKDADEIMVLQ-QGQCIDKGTYQQLSRNDSGFLSLLAEEVEEETGNESDGDDGSTRFGRPVSKQLSVEEVVRKRAGNVVDSCMSIMSAATTLTLPPEETKQEGAVSRQTYAAYLRSFHDLGTGVFLIFLFAM-CQVRPVMLMFGDVWLANWANREEVYSMTLASWNASSNTTSPSRPDLHYYLSVYAALVFGLFVLCLICTMSYYWFTIVASRNLHNGMFHSLIHTNMHFFDNNSIGRILNRFSKDIGVIDDFMPWMLCDVLQIGFSCLGIMCLVAASNPVSIAIVLPVICLFFYFRNYFMKSSREMKRIEGINRSPLFGHFSTTLLGIDTIRAYGVEATFTD-QFNLFHDAHSRAWYAYLAGQAWLTCRLQALG--VVF--LLFIVLGLPALKDGLSAGTVGLILSYSIMLAKLFEPFVEESAEVENIMTSVERVVEYTSLPPEGEKVTDVIPPPDWPDKGKITFDNMSFSYHQSLPEVLHNVTCVIKPSEKVGVVGRTGAGKSSLLSTLFRLAEP-KGLIDIDGINIRKLGLKDLRSKLSIIPQDPVLFSGTMRKNLDPFSEHPDAGLWKVLDEVQLKQPVEDLPGKLDEELAEAGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPRTDALIQETIRDKFQDCTVLTIAHRLHTIMDSDRVMVLDAGRLVEFDAPYKLLKKRNTIFSGLVE 1266 HSP 2 Score: 88.1965 bits (217), Expect = 1.960e-17 Identity = 74/281 (26.33%), Postives = 126/281 (44.84%), Query Frame = 2
Query: 1220 IENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEG-------------KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISE-RGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ 2020
+E L E E ++ P I N SFS+ + L+N+ ++ + + VVGR G GKSSLLS + + G + +G K++ +PQ+ + + T+R N+ KVLD L+ +E LP + E+ E G N S GQ+Q V LARA+ + S I ++D+ + VD +L + I ++ + T + + H L + D + V+ D G++ E Y+ L T F + ++ K ++ Q
Sbjct: 1006 VEYTSLPPEGEKVTDVIPPPDWPDKGKITFDNMSFSYHQSLPEVLHNVTCVIKPSEKVGVVGRTGAGKSSLLSTLF-RLAEPKGLIDIDGINIRKLGLKDLRSKLSIIPQDPVLFSGTMRKNLDPFSEHPDAGLWKVLDEVQLKQPVEDLPGKLDEELAEAGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPRT-DALIQETIRDK--FQDCTVLTIAHRLHTIMDSDRVMVL-DAGRLVEFDAPYKLLKKRNTIFSGLVEQTGGTEAKRLFDIAQ 1281 HSP 3 Score: 78.1814 bits (191), Expect = 1.959e-14 Identity = 123/553 (22.24%), Postives = 226/553 (40.87%), Query Frame = 2
Query: 2330 SRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGI-----VGIPILICYILLQVFYISSSRQARRLDSKASSFV---LTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYL---SLRWLCLRLDILG----------NLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNG--------NINLENFSLQYN--INLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVI-EAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALA 3883
++ A Y G+ GL LL + F G+R +++ VL + +T +G ++N + D D + + ++ +L + V++++ W+ I G+ +L+C +QV L KA ++ + + E +G +I+ E F KLI +L L+W I G LI F + + VL L+A+ V +S + N + CA F A+++ + ++ E + SE V + + ++ S +N I +P L ++ ++ G +GV+G G+GKSSL A+ + G I + G ++ Q +++ TL+ N+ +DE+ + ++K+ + + L+EG G G +LS GQ+ I LAR + I +LD+ ++VD R + E I I++ H+L+ + D D+I+ L G I+ G+ ++L N SG LA
Sbjct: 104 TKKEAYLYAAGVGLCGLFILLFNVPFAFMKNVYGMRVRAACTALIYKKVLHLSRTALASTTTGNLINLVSADAQKFDW---VRLAPFLHYLILGPLEVGVVAVLL-WYQIGPAALAGVGLLVCLAPMQV---KMGNALMSLRGKAIHWMDERVKIMNEIIAGMRVIKMYTWEDSFA-------------KLIMHLRKNELKWFLRMAYIQGAFASFFFSSAGLIYFTTFLVYVLTGEVLTAAKVFTCVS-------LFNSVRIVCALFFPFAITLFNESRVSLKRFEEALLLDEMHSEGLVKSTLRPKAEECGVFVKKASATWNKEIAIP-TLDGLSFDVPSGCLLGVIGAVGSGKSSLLNAILGELPLSEGSIRVQG-------------RVAYASQQAWVYNSTLRHNILFGKEYDEHRYNDVIKACALDKDFEL---LSEGDETLVGERGVSLSGGQRARISLARAVYADGDIYLLDDPLSAVDANVGRHLFQECICTYLKDKARILVTHQLQFLKDADEIMVLQQGQCIDKGTYQQLSRNDSGFLSLLA 612
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO46846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP39]) HSP 1 Score: 585.874 bits (1509), Expect = 0.000e+0 Identity = 409/1189 (34.40%), Postives = 636/1189 (53.49%), Query Frame = 2
Query: 542 KITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNI--RNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSW-----TEDGRPT-------------------LNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV---QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSL--LNNST-----------------------FNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNR--FSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQY-TMIPVESINETN----------------NYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 3889
KI+ ++RAA+ +Y KTL +ST + S+G+++N S D ++V+N F S PFQI +++ LLY ++G + AG+ +IPLN + +K+S + KD R+ I+ EI +G+++IK YAWE F K+ RN E+K++ R WC+ W P + +TFT Y + + +T K+F S+ LF L P+ PW ++ + A VS R++ FL E + D+ S G ++I +G FSW ++ + T L+ +NL++ +LI V+G VG GKSSLLSA+ EM L G V +G V QE WIQ+ T++ NIL K ++ Y V++AC L D++SLP D TEIGE GVNLSGGQK RV LARAVYQ+ IYLLDDPL+AVD +V L+ I+ GLL+HKT +L TH K+L D + V+++ G + G ++ SS+++ L Q S R+RS G + + N + + + EE G V L+ Y++A G + S +L+ ++ + G+ WL + +N+T N +N+ KFY+ Y I + + + F +GG++A+K IH LL ++L + + FF+ TP GRI+NRF+ D++ ID +L + + + ++ SLV+ PW ++ P++I Y LQ +Y +SR+ +R+ + S + H ET +G S IR+L F + ++ + + + ++ WL LRL +G I G AVL ++ LVGL++SYAL VT + + AE E VS+ER QY T IPVE + +S +W ++G I N L Y LP L+N+++ I+ GEK+G+VGRTG+GKSSL L LFR+VE G + +DGVNI S+ L +LR +L I+PQDP +FSG+++ N+DP+ + +D L +LE + V+ L G++ + G G N S GQ+QL+CLAR +L ++KI+ +DEATASVD ETDR + I+ F +STV+ IAHR+ T++D D+++ ++ G++ EF P L++N + F +L +
Sbjct: 187 KISYKIRAAIITTVYHKTLAVSTTSLGKFSSGEVLNFMSTDTDRVVNFANSFHQFWSLPFQIAVSLYLLYQQVGLAFLAGLGFALLLIPLNRWLAIKIQKYSTEMMTQKDSRVKIMNEILYGIRVIKFYAWENNFKNKVNTFRNAELKSLKGRKYLDAWCVY--FWATTPIIISILTFT--TYVLMGNQLTAAKVFTSVALFQMLITPLNAFPWVINGMMEAWVSVKRLQAFLTLEELDPDNYYIYIPAQSAGDAVQIVDGHFSWRYKPPQQEAKETKDVENLAEIETEVKSTVGLLSGLNLSIRKGQLIGVIGGVGSGKSSLLSALTAEMDKLTGQVFVAGLDGGFGLVAQEPWIQHATVKENILFGKPYDVDKYSDVINACALREDLQSLPAGDDTEIGENGVNLSGGQKARVGLARAVYQNKSIYLLDDPLAAVDAHVAAHLYKHCIT--GLLRHKTVILCTHHTKFLSGADHVIVMSN-GTVMHSGPPSEIL------------SSERI------LRQISRDVSRERSLDGKEGGEDGEENADEPTGDGR----LVEEEAKDVGAVRLHVYGSYWRAIGHCLATSILLSLLLMQGSRTIGDWWLAYWISHSKIDHTDNATTITHHSHDSTHPEAPYAAPFLRGVNIKKNTLKFYLVVYAGIAVANTVFTLFRAFLFAYGGIKAAKTIHQRLLSSILAAPISFFDITPIGRIINRFSSDVYSIDDSLPFMLNIFLAQAYFVVASLVITCYGLPWMALLVAPLMIIYYYLQGYYRKTSRELKRIITVTESPIYAHFSETLTGLSTIRALRHTQRFRTENEERLEVNQRANYCEMVAYVWLVLRLQGIGVAINAGVAFLAVLEHHFHTVDPGLVGLAMSYALSVTQSIADMVNSFAETEKQMVSVERAEQYITRIPVEKPGGSKVCHAHILLLSSLSDISRLLSSSWPTHGRIRFHNIVLVYRPGLPPALRNVSLEIHAGEKVGIVGRTGSGKSSLFLVLFRMVEVAEGAVILDGVNIASLPLDKLRSRLAIIPQDPFLFSGSVRDNIDPWGKCSDRDLWITLERCHLQQPVSDLG-GLDAEVGERGRNFSAGQRQLVCLARAMLTRAKILCIDEATASVDMETDRFIQRTIREAFRTSTVLTIAHRIDTVMDSDRVLVMNKGTVTEFEKPDTLMANQNSLFYSLVHS 1345
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO38355 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD35]) HSP 1 Score: 585.104 bits (1507), Expect = 0.000e+0 Identity = 396/1165 (33.99%), Postives = 620/1165 (53.22%), Query Frame = 2
Query: 527 FAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVD---MEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSL----ITPEKIFVSXXXXXXXXXXXXXXXXXXSQAI-SALVSFGRIENFLLASEKENDSNNSMPRKMSPG--APIEIQNGSFSWTED-GRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRL---------STSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATG---------IFVFGSSILACVIFGVLQAFGNVWLGMLADTQ---SLL------NNSTFNQSRN---SAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILG----NLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
F T + +R A M+Y+K + LS A S + G I+N+ + D +E+V + + WI P +++ ++ + ELG GV + + PL + K + L DKR I+ E+ GM++IKMY WE+ F + ++R E+ IR + + +V+ +VM I F F P L ++PEK+F + LF ++++ + + + + + VS R+++FL EK + ++ G A ++ N S W + PTL IN ++ L+ VVG VG GKSSLL +LGE+ +G + +G+++Y Q+AWI + ++R NIL K + + Y +V+ AC +E D+ PN +T +GE+GV LSGGQK R++LARAVY D+DI LLDDPLSAVD +VG+ LF++ + GLLK + VLVTH L++L +I + D G+ +G+Y L + G + S ++ S + +N+I P N S + G Q GN + E + S E + +G V+ + YFKA + +FGS + V G WL AD++ S L NST + YI C G+I G + +++ + F AS+ +H + VLR+ + FF+ P GR++NRF KD+ +D L D + R L +TSL+ S+ P+ + IP+ + + ++ +Y+ +SR+ +RL++ S V +HL + +G IR+ +AE F + D + + + RWL RLDI+ L F S +F V S ++VGL ++YA Q+TG+ W RQ AE E N S+ER+ +Y+ I E ++W G I E+ Y+ +LP VLKN+ +I EK+G+VGRTGAGKSSL LFRL G + IDG+ I + L LR ++I+PQDPV+FSGTL++NLDPF +++DD L +LE + + V+ L +G+ + G+N S+GQ+QL+CLAR +L +KI+++DEATA+VD TD + E I+ +F TV+ IAHRL T++D D+++ LD G ++EF P LL NS G F L +
Sbjct: 131 FFQTFRCGFHLRIACSTMVYRKAMCLSHSAYSTVTTGHIINLLTSDVQILERVAVFLHHLWI---APVLLLVTSVISWYELGPYCLPGVIVVVLIAPLQGWLGKKFAVIRNKTALQTDKRFRIMNEVISGMRVIKMYTWERPFANLVADVRRYEVSIIRKAAYLRSVNAVI------YVMCIPVIGFAMFAPYVLTGHALSPEKVFTVIALFYSIRVSLTIFLPECIRGLKESKVSAKRLQSFLERDEKHSMKGVRTLTELKEGETASVKANNFSARWNDMISTPTLQGINFELKPSDLLMVVGPVGAGKSSLLMCLLGELPLTSGYISVKGRVSYASQQAWIFSGSVRENILFGKEYEEAKYWRVIKACAMERDMRLFPNGYETLVGEKGVALSGGQKARINLARAVYYDADIVLLDDPLSAVDTHVGRQLFDECV--YGLLKDRICVLVTHQLQYLKGATDIICLQD-GRCVGQGSYAELSEAGLDVMSLVSALSAG---DHDNIISPDIINVPPSSAQFPVPLANGSTRPGYQKISGNVDDAPEGEVLAREPSKEGQ-HTGTVTWQVYIEYFKAGASPCVRFLIVMLLFGSQAVVMV--------GEWWLAKWADSEKEKSYLIESYRGTNSTPPPPADLTTHEYIYIYC-GMICAGMVTSLVCAMMLYNFFVT-ASQHLHDNMFSRVLRAPIYFFDTNPVGRVVNRFAKDINQMDDVLPAAFYDFL-RVSLNLTSLLGSSM--PFLLVGAIPMTVLFGYIRNYYLRTSREVKRLEAINRSPVYSHLSTSLTGLITIRAFQAEQAFIRSYHAYTDFHTGSYFLFHTTQRWLGFRLDIICASFFTLATFTS-LFIVEGGLS---NVVGLCLTYATQLTGMFQWCIRQSAEVENNMTSVERVIEYSQIDQEVEPSKPLTAPDDWPHTGTITAESLYYSYHQSLPHVLKNVKFSIRNNEKVGIVGRTGAGKSSLLAVLFRL-NNPEGLVRIDGLPITDLKLQDLRSAISIIPQDPVLFSGTLRKNLDPFTQFSDDALWNALEEVQLKEAVDELPDGIETELAEGGSNFSVGQRQLVCLARAILSHNKILVIDEATANVDHSTDSLIQETIRNKFHDCTVLTIAHRLNTVMDSDRVMVLDAGRLVEFDEPYVLLLNSQGFFSQLVE 1261
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 811.216 bits (2094), Expect = 0.000e+0 Identity = 494/1310 (37.71%), Postives = 777/1310 (59.31%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-----------SENSEKCLKYLKENLRSPNIES-----EIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAP--IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQP---SAPNKRKRSRLSTSGSQGFDGNENAEENYEK--YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 3874
PE +S LS+IT+ W+ + +K ++++ + LN + S + K + ++ L SP E+ +E+ + LI K K ++ +LC + P + K+ +DIL+ P +L+LL+ ++ + D +W+G A L F SL F + +R+R A+ G IY+K L +S+ AR + G+IVN+ SVD ++ M+ +TY + S P Q++LA+ L+ LG S+ AGV + ++P+N +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F +K+ +IR +E+K ++ + + + W PF V TF+ ++ +++ EK FVSL LFN L+ P+ +LP +S + A VS R+ FL E + DS + R + G+P I I++G FSW+ PTL +N+ + L+AVVG VG GKSSLLSA+LGEM + G+V +G +AYVPQ+AWI N TL+NNI+ + + +Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDDPLSAVD +VG+ +F+ +I QGLLK KTR+LVTHGL +LP + V+ D G+I+E G+Y+ L + F FL NE S++ + N+ +P S+ +++ S+G +N E+ K + ++ ++GRV L+ Y KA G+ + S+L + +L F N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + + + ++ S ++I + TP ++ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ + F + +D + K ++ RWL +RL+ +GN IV + +FAVL R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y+ E+ + +W + G I + NF L+Y +L ++NI ++I+GGEK+G+VGRTGAGKSSL L LFR++E G IFIDGV+I +GLH+LR ++TI+PQDPV+FSGTL+ NLDPFD Y+D+ + K+LE S + +V+ L + + ++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ ++
Sbjct: 209 PEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKS----PKKSREPSLLWALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAP-SWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDS---VERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVD-GEITEVGSYQQLKEKEGAFAEFLRMYAANEQSEETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQKNSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTD------DPVVNGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALI-IPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAQKGAFYR 1502
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:101175305]) HSP 1 Score: 801.201 bits (2068), Expect = 0.000e+0 Identity = 492/1353 (36.36%), Postives = 771/1353 (56.98%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCL-KYLKENLRSPNIESEIHDIEDKKCLIGKKNF-------------------NEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWK---GILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGA-PIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-------------------------------NESSDKVDKN------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINET-NNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 3886
PE + LS +T+ W + +K ++ + + L ++S + L ++ KE ++ + ++ + K K N N++ + F ++++ + + P G K+ +D++ P +L LL+++ K +D+ W LM F Q L YCF + VR AL G IY+K L ++ A+ + G+IVN+ SVD ++ M+ + + S P QI+LA+ L+ LG S+ AGV + +IPLN I +R + ++ KD R+ ++ EI +G+K++K+YAWE+ F +K+ +IR E+ +R + + ++ W PF V +F F+ N+++ ++ FVSL LFN L+ P+ +LP +S A VS RI+NFL E + DS + RK +PG + + NG+F+W ++ P L+++++ V L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TLR+NIL ++N+ Y VLDAC L D+E LP DQTEIGE+G+NLSGGQ+QRVSLARA+Y D+D+YLLDDPLSAVD +V + +F++LI GLLK KTR+LVTHG+ +LP VD I V+ G++SE G+++ L+ F FL N D ++ Q +++ N R+RS SQ G E E+ +K + E +GRV + Y KA G+ + +L N+WL N++ N ++ + + ++ Y +G+ Q + V++ G + A++++H+ LL L + FF+ TP GRI+NRF+KD+++ID L + + +++++VI TP+F ++ IP+L + Y+ +Q FY++SSRQ +RL+S + S + +H ET +GSS+IR+ F + +D++ + +S RWL +R++ +GN IV + +FAV+ + +L+ LVGLS+SYALQVT LNW+ R ++ E N V++ER+++Y+ E+ E + W ++G + +S++Y L VLKNIT+++ GGEKIG+VGRTGAGKSS+ L LFRL+E +G I IDGV I IGLH LR +LTI+PQ+PV+FSGTL+ NLDPFD+Y+D+ + K+LE S + +V + + +C G NLS+GQ+QL+CLAR LL+K++I+ILDEATA++D ETD + I+ QF +STV IAHRL TI+D +++ LD G I EF +P L+S G F +A+
Sbjct: 205 PETTAGFLSSMTFWWFTSLALKGYKMPLEAKDLWSLKKRDSSETMVPRLLAEWRKEEAKARSQQNLSGQAQYAKLPPSKANHLSGDEAEDNGPKEGDVLLSNQKAQKQPSF-LRAILKAFGPYFLIGSAYKLLQDVITFINPQLLSLLISFTKQEDVPLWWGYTLAFLMFFTAFLQTLILHRHFQYCFVTG----MNVRTALIGAIYRKALVITNAAKRSSTVGEIVNLMSVDAQRFMDLTAFLNMLWSAPLQIMLALYFLWENLGPSVLAGVAVMVMLIPLNAFIAMKTRAYQVEQMQHKDARLKLMNEILNGIKVLKLYAWEESFKQKVLDIRQKELNVLRKTAYLGALSTMAWTSAPFLVALTSFAVFVSVDENNVLDAKRAFVSLSLFNILRFPLNMLPQVISSIAQASVSLKRIQNFLSHDELDPDSVD---RKNTPGDFSVTVVNGTFTWAKEDPPVLHSVSVMVPRGSLLAVVGPVGCGKSSLISALLGEMEKLEGEVSIQGSVAYVPQQAWIQNATLRDNILFGNAYNEQKYCSVLDACALTQDLEVLPGGDQTEIGEKGINLSGGQRQRVSLARALYSDADVYLLDDPLSAVDAHVAKHIFDRLIGPDGLLKEKTRILVTHGISFLPQVDNIMVLG-AGRVSEMGSHQELLKQNGAFAEFLRNYALEDILEEDELEDELLDEMEFFPEEELGNHHCDMMENEPVMNEARKAFMRQMSVLSADGENPRRRSVRRHGCSQRKRG-EPPEK--KKELEKLIQAETAETGRVKTKVYLEYVKAVGVLLSVLILLLYGCQSAAAIGSNIWLSQWT------NDAAGNHTQENVQMRVSVYAALGIAQGILVMISSYTLAMGNISAARRLHANLLTNKLHTPQSFFDTTPIGRIINRFSKDVYVIDEALPSTVLMFLGTFCASLSTMIVIVCSTPYFALI-IPVLALIYVFVQRFYVASSRQLKRLESVSRSPIYSHFSETVTGSSVIRAYGRLDAFVLMSDAKVDENQRSYYPGIVSNRWLGVRIEFIGNCIVLFAALFAVIWKETLNPGLVGLSVSYALQVTMSLNWMVRMTSDLENNIVAVERVKEYSETKPEAPWEVEDKKPPPEWPTDGKVEFHGYSVRYRDGLDLVLKNITLDVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEITIDGVKIAEIGLHDLRSRLTIIPQEPVLFSGTLRMNLDPFDKYSDEDVWKALEHSHLHGFVRNQPAQLQMECAEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFENSTVFTIAHRLNTIMDYTRVLVLDKGKIAEFDTPTNLISK-RGIFYGMAK 1537
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc6a (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101158001]) HSP 1 Score: 796.193 bits (2055), Expect = 0.000e+0 Identity = 477/1321 (36.11%), Postives = 753/1321 (57.00%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS--------SENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLST----------SGSQGFDGN-------------ENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNV----WLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE-SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 3889
P +S LS+I + W + + ++ ++ + L +TS E +C K K+ + + D+ L+ K + SG F++++L R + P G + IF D + + LL + WKG A L F SL + + +RV+ A+ G++Y+K+L +++ AR + G+IVN+ S D +++M+ + Y P +I L + L+ LG S AG+ + + PLN I K K E ++ F D R+ ++ EI +G+KI+K YAWEK F +++ R E+K ++ V + I ++ F + + F ++ +++ +K+FVS+ L N L+ P+ LP+ +S + ALVS R+ +L + E + D S S G + I+NG+FSW+++G P L I++ V L+AVVG VG GKSSLLSA+LGE +G V +G +AYVPQ+AWIQN T+++NIL + K +Y +VL+AC L D++ LP D TEIGE+G+NLSGGQKQRVSLARAVY+ +D+YLLDDPLSAVD +VGQ +F+K+I +G+LK +TR+LVTHG+ +LP D I V+ D G+I+E G+Y+ L+ F F++ + + + + IQ A ++R +RLS S Q G+ EN ++ + ++ ++ +GRV L+ YFK G+ + I+ V Q ++ WL M AD + N ++ + +G +G Q +A+ G+ AS+++H LL VLRS + FF +TPSG +LNRF K++ ID + + +++ L+ +++ I TP ++ +P+ Y +Q FY+++S Q RRL++ + S + TH ET G+S+IR+ +S F +D + ++++ RWL + L+ +GN +V + + +V+ + ++S +VGL++S++LQVTGIL+W+ R + E N VS+ER+ +Y P E S N + + W +G I +++ LQY L LK IT+ I EKIG+VGRTGAGKSSLAL +FR++E GRIFIDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ SLE++ + D+V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I +D G I E SP L+S ++ +A
Sbjct: 206 PVKDASFLSKILFWWFTGLVVKGYRTPLEATDLWTLREEDTSHKIISDLQQEWGAECAKLQKQEKSLESAPVLGSRLPDQAQLLRKLQKEQS---SGFFLLRTLARKFGPYFLTGTLCIIFHD-AFMFAIPQVLSLLLGFIRDPEAPQWKGYFYATLMFLLSCLQSLFNHQYMYTCFTVGMRVKTAVMGLVYRKSLVINSAARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEIGLCLFFLWQHLGPSALAGIATVILIFPLNGFIAKKRSKLQEIQMKFMDGRVRLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKALKKSQVLYSISIASFNSSSFLIAFAMFGVYVMLDERNVLDAQKVFVSMALINILKTPLSQLPFAISTTMQALVSLRRLGKYLCSEELKVD-GVSKALSSSDGEDVVIENGTFSWSKEGPPCLKRISVRVPRGSLVAVVGHVGSGKSSLLSAMLGETEKRSGQVTVKGSVAYVPQQAWIQNATVQDNILFGREKLKTWYQRVLEACALLPDLDILPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKADLYLLDDPLSAVDAHVGQHIFDKVIGPKGVLKDRTRILVTHGMSFLPQADLILVLID-GEITESGSYQELLSHHGAFADFIHTFAST--EKKESAIQ-RAGSRRSNARLSMVDFMPFSRDLSQEQLIGGDTTNTNLQNMEPVSENDQDQVPEDLGKLTEADKAHTGRVKLDMYKKYFKTIGLAI----IIPIVFLYAFQQGASLAYSYWLSMWAD------DPVVNGTQTDRDLKLAVFGALGFVQGIAIFGTTVAISICGIIASRQLHMDLLVNVLRSPMAFFESTPSGNLLNRFVKEIDAIDCMVPEGLKMMLSYVFKLVEVCIIVLIATPIAAVIILPLAFLYAFVQSFYVATSCQLRRLEAVSRSPIYTHFNETVQGASVIRAFGEQSRFIMQANERVDFNQTSYFPRFVATRWLAVNLEFVGNGVVLAAAVLSVIGKSTVSPGIVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVNEYADTPKEASWNTEGSALPLAWPQSGTIEFQDYGLQYRKGLELALKGITLQIQKREKIGIVGRTGAGKSSLALGIFRILEAAKGRIFIDGVNIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDIYTDEEIWSSLELAHLKDFVSNLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDTLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGYISEMDSPANLISQRGQFYRMCREA 1507
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: ENSORLT00000010371.2 (canalicular multispecific organic anion transporter 1 [Source:NCBI gene;Acc:101165337]) HSP 1 Score: 793.882 bits (2049), Expect = 0.000e+0 Identity = 472/1169 (40.38%), Postives = 708/1169 (60.56%), Query Frame = 2
Query: 524 CFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLI----------------------QPSAPN--------KRKRSRLSTSGSQGFDGNENA------EENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQ-AF--GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHED 3913
CF + K VR A+ +YKK L +S + R + G+ VN+ S D ++ + + + SCP QII++I+ L+LELG S+ AG+ + ++P+N ++ +RK+ + + FKDKRM I+ E+ +G+KI+K++AWE F ++E IR +E+K ++ + + + ++ P V +F F+ P++++T EK F S+ LFN L+ P+ +LP ++ + VS R+E FL + E D P S + + ++NGSFSW D P L +++L++E +L+AVVG VG GKSSL+SA+LGEM+ G + +G +A+VPQ+AWIQN TLR+NIL + + +V+ AC L D++ L + TEIGE+G+NLSGGQKQRVSLARA Y +DIYLLDDPLSAVD +VG+ LF+K+I G+LKHKTR+LVTHG+ +LP+VDE+ V+ D G+ISE G+Y L F FL D K QNN QP +P KR+ S + S +N+ + N K + +E + +G+V + + Y +A G +G + + +I+ + AF N+WL + + N T+ + + + +G +G+ Q V L + AS+ +HS LL+ +LR + FF+ TP GR++NRF KD+F ID + + + + ++ +L VI + TP+F I+ +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF S +FAV+++ SL + LVGL+ISYAL VT LNWL R +E ETN V++ER+ +YT I E+ T+ E W G + ++ ++Y L VL IT NI EKIG+VGRTGAGKSSL LFR++E GRI ID V+I++IGLH LR +LTI+PQDPV+FSGTL+ NLDPFD+++D++L K+LE+S + D+V L EG+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL +I+D +++ LD G I+EF SP LL N G+F ++A+ D I E+
Sbjct: 265 CFVLGMK----VRTAVMAAVYKKALVVSNDTRKESTVGETVNLMSADAQRFNDVTNFIHLLWSCPLQIIVSIVFLWLELGPSVLAGLLVMVLMVPINGLLATQARKYQVQNMNFKDKRMKIMNELLNGVKILKLFAWEPSFQSQVESIRGEELKVMKKFAYLSSVSTFIFSCAPALVSLASFAVFVLVSPDNILTAEKAFTSISLFNILRFPLAMLPMLIASIVQTGVSKKRLEKFLGGEDLEPDIVRHDP---SFDSAVSVRNGSFSWERDAEPLLKDVSLDIEPGRLVAVVGAVGSGKSSLMSALLGEMHCTEGFINIKGSLAFVPQQAWIQNATLRDNILFGSPHEEKRFQEVIQACALGPDLKLLAAGELTEIGEKGINLSGGQKQRVSLARAAYSQADIYLLDDPLSAVDSHVGKHLFDKVIGPNGVLKHKTRILVTHGVSFLPYVDEVVVLVD-GKISEIGSYNSLRASKGAFSEFL----DTYAKEQNNQTKSDKDGCQDTEDLEIIPEREDTQPDSPLEDTVSFTLKRENSIRRSQRSSSVRVRKNSTVKKSEDANETKAGQRLIEKETMETGQVKFSVYLQYLRALG---WGYTSMVFIIYFIQNVAFIGQNLWLSDWTNDAADYYNQTYPNWKRDTR--VGVFGALGIAQGFLVFLGTLLLANASVSASRILHSRLLNNILRVPMVFFDTTPVGRVVNRFAKDIFTIDEAIPQSFRSWLLCLLGVLGTLFVICLATPFFTIIILPLAVIYFFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYRHQDRFLKHNEVTIDENLKSVYPWIVSNRWLAIRLEFLGNLVVFFSALFAVISKDSLDSGLVGLAISYALNVTQTLNWLVRMSSELETNIVAVERVSEYTEIENEAKWITDCRPPERWPDEGKLQFIDYKVRYRPGLDLVLHGITCNIASSEKIGIVGRTGAGKSSLTNCLFRIIEAAEGRILIDDVDISTIGLHDLRGRLTIIPQDPVLFSGTLRMNLDPFDKFSDEELWKALELSHLKDYVAGLQEGLQHEVAEGGENLSVGQRQLLCLARALLRKSRILILDEATAAVDLETDNLIQNTIRKEFAHCTVLTIAHRLHSIMDSSRVMVLDAGKIVEFDSPSNLLEN-RGYFFSMAK-DAGITQEE 1414
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 792.727 bits (2046), Expect = 0.000e+0 Identity = 486/1280 (37.97%), Postives = 761/1280 (59.45%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETS-----------SENSEKCLKYLKENLRSPNIES-----EIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAP--IEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQP---SAPNKRKRSRLSTSGSQGFDGNENAEENYEK--YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIID 3784
PE +S LS+IT+ W+ + +K ++++ + LN + S + K + ++ L SP E+ +E+ + LI K K ++ +LC + P + K+ +DIL+ P +L+LL+ ++ + D +W+G A L F SL F + +R+R A+ G IY+K L +S+ AR + G+IVN+ SVD ++ M+ +TY + S P Q++LA+ L+ LG S+ AGV + ++P+N +I ++ + ++ KD R+ ++ E+ +G+K++K+YAWE F +K+ +IR +E+K ++ + + + W PF V TF+ ++ +++ EK FVSL LFN L+ P+ +LP +S + A VS R+ FL E + DS + R + G+P I I++G FSW+ PTL +N+ + L+AVVG VG GKSSLLSA+LGEM + G+V +G +AYVPQ+AWI N TL+NNI+ + + +Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDDPLSAVD +VG+ +F+ +I QGLLK KTR+LVTHGL +LP + V+ D G+I+E G+Y+ L + F FL NE S++ + N+ +P S+ +++ S+G +N E+ K + ++ ++GRV L+ Y KA G+ + S+L + +L F N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + + + ++ S ++I + TP ++ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ + F + +D + K ++ RWL +RL+ +GN IV + +FAVL R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y+ E+ + +W + G I + NF L+Y +L ++NI ++I+GGEK+G+VGRTGAGKSSL L LFR++E G IFIDGV+I +GLH+LR ++TI+PQDPV+FSGTL+ NLDPFD Y+D+ + K+LE S + +V+ L + + ++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D
Sbjct: 247 PEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKS----PKKSREPSLLWALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAP-SWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDS---VERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVD-GEITEVGSYQQLKEKEGAFAEFLRMYAANEQSEETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQKNSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTD------DPVVNGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALI-IPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1510
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074226.1 (SMESG000074226.1) HSP 1 Score: 2429.44 bits (6295), Expect = 0.000e+0 Identity = 1282/1311 (97.79%), Postives = 1284/1311 (97.94%), Query Frame = 2
Query: 26 TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ--------------DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 3916
TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKF+IKSLCRVYFPIIFFGWILKIFRDILVLTLPLVLKLLLNYLKNKDLSYTWKGILMALLFFFQGLFGSLCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQIILAILLLYLELGYSIFAGVTAIGA+IPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSLVLFNNLQLPILLLPWGLSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVE QKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKI YG VLDACCLEYDI SLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFD NENAEENYEKYFNDIS EEEIMSGRVSLNSIVWYFKATGIFVF SSILACVIFGVLQA GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FG LRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDH LNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLK NLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK
Sbjct: 123 TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFLIKSLCRVYFPIIFFGWILKIFRDILVLTLPLVLKLLLNYLKNKDLSYTWKGILMALLFFFQGLFGSLCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQIILAILLLYLELGYSIFAGVTAIGAIIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSLVLFNNLQLPILLLPWGLSQAISALVSFGRIENFLLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKILYGTVLDACCLEYDIGSLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDDNENAEENYEKYFNDISQEEEIMSGRVSLNSIVWYFKATGIFVFASSILACVIFGVLQAIGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGSLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHILNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKHNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 1433
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074229.1 (SMESG000074229.1) HSP 1 Score: 1987.62 bits (5148), Expect = 0.000e+0 Identity = 1052/1308 (80.43%), Postives = 1158/1308 (88.53%), Query Frame = 2
Query: 26 TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEF--KYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMP---RKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ--------------DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQAD 3892
T++PE +S+ SQ+TY WMD +IY W+K +M D+TSFDL++TE SS NSE +Y +I ED++ LI + E F ++SGK +IKS+ +F II +L+I RDIL+LTLPLVLKLLLNY K K +YTWKG+L A +F QGL GS+ ENYCF +T+KI++RVR ++ GMI +KTLRLS EA++ +SAGDI+NM VDMEQ+MN I YSWI +SCPFQIIL ++LLY ELG SIF GV I VIP+ I IM+ ++K+SE+EL++KDKRM+ILTEI +G+K+IKMY WEK F KIE IR++E+KN RN S+GWCI++V++DLVPF VMY TFTF+IYFVP S+I+ EK+F+++VLFNN+QLP+LLLPWG++Q I+A+VSFGRI FLL++E S S+P +MSP A IEIQ+G FSWT+ G P L NI L VE QKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYG VLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRF+KDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV+NRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNIT+NINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVN L +G+ YDCG MG NLS GQKQL+CLART+LK SKIIILDEATASVDE+TDRRV +AI QF +STVIIIAHR+KTII CDKI++ ++GS++EFGSP+ELL ++G F+ +++
Sbjct: 58 TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEE-KESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRHEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRS--SVPLVVTQMSPDASIEIQSGRFSWTKIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFSKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVVNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLSTGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQFRNSTVIIIAHRIKTIIGCDKILYFENGSVVEFGSPQELLLKANGKFRFFVKSE 1362
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074229.1 (SMESG000074229.1) HSP 1 Score: 1986.46 bits (5145), Expect = 0.000e+0 Identity = 1052/1308 (80.43%), Postives = 1158/1308 (88.53%), Query Frame = 2
Query: 26 TENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEF--KYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDSNNSMP---RKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ--------------DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQAD 3892
T++PE +S+ SQ+TY WMD +IY W+K +M D+TSFDL++TE SS NSE +Y +I ED++ LI + E F ++SGK +IKS+ +F II +L+I RDIL+LTLPLVLKLLLNY K K +YTWKG+L A +F QGL GS+ ENYCF +T+KI++RVR ++ GMI +KTLRLS EA++ +SAGDI+NM VDMEQ+MN I YSWI +SCPFQIIL ++LLY ELG SIF GV I VIP+ I IM+ ++K+SE+EL++KDKRM+ILTEI +G+K+IKMY WEK F KIE IR++E+KN RN S+GWCI++V++DLVPF VMY TFTF+IYFVP S+I+ EK+F+++VLFNN+QLP+LLLPWG++Q I+A+VSFGRI FLL++E S S+P +MSP A IEIQ+G FSWT+ G P L NI L VE QKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYG VLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ DSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRF+KDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV+NRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNIT+NINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVN L +G+ YDCG MG NLS GQKQL+CLART+LK SKIIILDEATASVDE+TDRRV +AI QF +STVIIIAHR+KTII CDKI++ ++GS++EFGSP+ELL ++G F+ +++
Sbjct: 199 TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEE-KESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRHEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRS--SVPLVVTQMSPDASIEIQSGRFSWTKIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFSKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVVNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLSTGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQFRNSTVIIIAHRIKTIIGCDKILYFENGSVVEFGSPQELLLKANGKFRFFVKSE 1503
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000283.1 (SMESG000000283.1) HSP 1 Score: 1014.22 bits (2621), Expect = 0.000e+0 Identity = 607/1363 (44.53%), Postives = 866/1363 (63.54%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKN------------FNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASEKENDS----NNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE-------SSDKVDKNQNNLIQP-----SAPNKRKRSRLSTSGS---QGFDGN--------------------------------ENAEENYEKYFN----DISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSL-------LNNSTF-----NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYIS--ENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 3880
PE ++S +S++T+ W D YIY+W KEEM +E SF+L + + S KY+ NL + +I ++K I K N F E+ SG + L +V+ + W+LK+ D L+L P +LK+LL Y+ +++ + TW +A F G+ S+ ENY + +TS ++VR+RA + GMIY KTLRLS EAR+ ++ G+IVN+ SVD E++M I +SW SCPFQII+A +LLY E+ Y+IFAG +PLN ++MK++ FS+ EL +KD+R+ I +EI G+K+IKMY WE+ F KI +RN E+K I + W I+ ++W+++P ++ + F++ + IT EK FVSL LFN ++ ++++P+GL++ ++A VS RI +L+ E E N ++ IEIQ G+FSW + LNNINL++ KLIAVVG++G GKSSL+SAILGEM T++G V+ +G+IAYV QE WIQN TL+NNIL T+ +N+ FY KV+ +CCL D+E LP D+TEIGERG+NLSGGQKQRVSLARAVYQ+ DIYLLDDPLSAVD +V SLF +ISN G+L KTRVL+THGL WLP VDEI V+++ G IS+RG+++ L++ +FK F+ + S + + + ++I+ S N + + SGS FD + E +EEN + + EE+ G V Y K+ G+ +F ++L F LQ F +W+ + + + L N+++ NQ R +FY+ Y I + + V LFW F G + K IH LL ++LR ++FF+ TP GRILNR + D+ ++D + +N+++ + ++++S++VI VTPWF IV IP+ I Y +Q Y+ +SRQ+RRLD+ A+S V ET G SIIR+ + ES F+ + Y IDK+++F+ IQ S+RWLC R+DI+G+L+VF +VI ++ N L+A LVGLSISY+LQVT LNWL RQ E E N V++ERIR+Y+M+P E+ E N+ + ENW + GNI L+Y +L VLKNI +++NGG K+G+VGRTGAGKSSL LALFRL+E +G+I IDG++I++IGLH LR++LTILPQDPVIFSGTL+ NLDPF+ +TD+ L + LE + + DWV+SL EGMNY+CG G NLS GQ+QL+CLAR LL+KSKI+ILDEATASVD ETD+ V+ +K F STVIIIAHR+ TI+D DKI+ LD G ++E GSPK+LL + G FK+L
Sbjct: 128 PEEYASTISKLTFSWFDSYIYKWRKEEMTEENSFELRSNDESK-------KYI--NLVEKSFLKKIEFCKEKSKQINKSNSSKNLLTDNDEEFREKKHNSGWILFSCLSKVFLFQLVVAWVLKLIGDTLLLFTPYLLKILLRYVNSENKT-TWISYGIAFTFLANGILSSIMENYSYFMTSYLSVRIRAVIIGMIYSKTLRLSREARNKYTTGEIVNLMSVDAERIMVFIDFSWFIFSCPFQIIIATVLLYQEMNYAIFAGFGLFLVFLPLNGLLMKYAHGFSDVELKWKDERIKIFSEILTGIKVIKMYGWEQSFISKITGLRNLEVKYILRSQIIWGIVYIIWEILPSLIIMVMILSFVFMNRFNFITAEKAFVSLSLFNLIRFSLIIVPYGLTETVNAFVSLKRIAEYLMVEEMEPIGFTYLQNLYEEQLENDPAIEIQGGTFSWKRSDKVILNNINLSIAKGKLIAVVGKIGSGKSSLISAILGEMVTISGDVKIKGRIAYVSQEPWIQNRTLKNNILFTEDYNETFYKKVVVSCCLTQDLEQLPMGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDSHVAHSLFENIISNNGILGGKTRVLITHGLNWLPKVDEIVVLDNSGHISDRGSFKDLLENSLKFKQFIKDHMNPGKNSVNGANFSHESIIEEKVKHHSPENDQLLYEIPDSGSGIETEFDLDYHGPFISKESSPLQFTVVDDADIELHNKIKDLEFSEENNHNLISRSNGQLIDEEQAFVGNVKAKEYFVYVKSRGLLLFLLTVLIYSSFVALQVFSFIWIEKFTEDKVIQNLSNLILKNASYVIDQSNQIRERTEFYMIRYSFICIAMIGVVSLFWVCFAMGTYNSMKYIHGKLLYSILRCPMEFFDTTPVGRILNRLSHDMDLMDRKMPVNLSESFSCFFVVLSSIIVIIYVTPWFAIVIIPLFIFYYFIQFLYMPTSRQSRRLDAIATSPVFNIFTETIQGISIIRACKVESYFQELSYEIIDKNSRFRFIQVSSMRWLCFRIDIIGSLVVFFAVILSITNVSYLTAGLVGLSISYSLQVTEALNWLLRQYTEVEMNMVALERIREYSMVPSEA--EWNSLMPPPENWPNIGNIKFIELDLKYRESLSFVLKNINLDLNGGYKVGIVGRTGAGKSSLTLALFRLMEASNGKIVIDGLDISTIGLHDLRKRLTILPQDPVIFSGTLRENLDPFNVHTDEDLYQCLETAHLQDWVSSLNEGMNYECGEGGVNLSAGQRQLLCLARALLRKSKILILDEATASVDFETDKLVMTTVKEYFRQSTVIIIAHRINTILDTDKIVVLDSGEVVEIGSPKDLLEQADGIFKSL 1478
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000273.1 (SMESG000000273.1) HSP 1 Score: 929.858 bits (2402), Expect = 0.000e+0 Identity = 555/1240 (44.76%), Postives = 778/1240 (62.74%), Query Frame = 2
Query: 35 PENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYL-----------KENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFVIKSLCRVYFPIIFFGWILKIFRDIXXXXXXXXXXXXXXXXXXXXXSYTWKGILMAXXXXXXXXXXXXCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQXXXXXXXXXXXXGYSIFAGVTAIGAVIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSXXXXXXXXXXXXXXXXXXSQAISALVSFGRIENFLLASE----KENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVENQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE---------------SSDKVDKNQNNLIQ------------------PSAPNKRKRS--------RLSTSGSQGFDG----------------------------------------NENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNST---FNQS---------RNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQ 3430
PE ++S+LS++TY W+D YIY+WF++EM DETSFDL + S++N+ K + +L + S H +ED+ L N + G + SL RVY + K D + +P +LK+LL Y++N+ +Y W G +A+ F F G+ SL EN CF ITS +++R+RAAL GMIY+KTLRL+ E R+ ++G+IVN+ SVD E++MN I ++W F+SCP QI+LAI+LLY E+ Y+IFAG+ I A PLN ++M +KFS EL +KD R+ ILTEI +G+K++KMYAWEK F KI +R+ E++ I VS + ++ VLW+++PF +M TF ++ ++ITPEK FVSL LFN L+ P+++LPWGL+ +++A VS RI +L+ E + N + + A IEI++GSFSW ++ + TLNNIN + KL+A+VG+VG GKSSL+SAILGEM+ +NG+V +G IAYV QEAWIQN +L+ NIL T+ +N+ Y +++AC L+ D+E LP D+TEIGERG+NLSGGQKQRVSLARAVYQ+ DIYLLDDPLSAVD +VGQ LF +ISN G+LK KTR+LVTHGL WLP VDE+ V++ G ISERG+++ L+ EF F+ E + K +N L Q P+ P +R S RLS+S S+ DG ++N + +K + + EE+ MSG V + K+ G+++F +++ F LQ F N+WL + + N S N S R K+Y+ Y IIGL L V +W F G + ASK IH LL +VLRS ++FF+ TPSGRI+NRF+KD+ +DH + +NI+D ++ ++ S++VI VTPWF I IP+ I Y L+Q+FYI +SRQ+RRLDS A+S V H ET G ++IR+ + + F+++ IDKS+KFK IQ S+RWL LR++ILG L+VF +V+F+++ RFSL+ASLVGLSISY+LQ+T LNWL RQ E ETN V++ERIR+Y+ IP E+ + NN S++W +NGNI +++ L+Y LP VLKNI ++ +GG+KIGVVGRTGAGKSSL LALFRLVE G I ID +NI++IGLH LR++LTILPQ
Sbjct: 25 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDN-----RSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY-WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHREFTDNSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNASDRLSSSISKSIDGFSRHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDMENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFAIAIIPLAILYYLIQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDKSSKFKFIQQSSVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSITIDKINISTIGLHDLRKRLTILPQ 1258 HSP 2 Score: 88.5817 bits (218), Expect = 2.718e-17 Identity = 116/514 (22.57%), Postives = 223/514 (43.39%), Query Frame = 2
Query: 2441 SKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVL----------LITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVL----NRFSLSASLVGLSISYALQVTGI-LNW-LTRQCAEFETNAVSIERIRQYTMIPVESINETNNY-ISENWVSN--GNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQ---FVSSTVIIIAHRLKTIIDCDKIIHLD-DGSIIEFGSPKELLSNSSGHFKALAQADEYIKHED 3913
S +I + L+ + R TL+ N I N+FT + + ++++ I+N + ++ +++++ + G+ +++ + L ++ ++ ++ K + L E +G +++ E F D ++ L + +C+ +IL LI+ + + VL N + + V L++ L+ + L W LT F VS++RI QY + ++ E N+ ++N N I + + S + L NI I G+ + +VG+ G GKSSL A+ + +G + + G + + Q+ I + +LK N+ +Y + +E + + L G + G G NLS GQKQ + LAR + + I +LD+ ++VD + + E + T I++ H L + D+++ LD +GSI E GS K+LL + + F Q EYI+H +
Sbjct: 201 SIRIRAALIGMIYRKTLRLNN-----EIRNKFTSGEIV--NLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAF----VSLKRIGQYLVGEELNLTEINHREFTDNSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCN-EFMQFVQ--EYIEHNN 687 The following BLAST results are available for this feature:
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014286 ID=SMED30014286|Name=Multidrug resistance-associated protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4099bpback to top protein sequence of SMED30014286-orf-1 >SMED30014286-orf-1 ID=SMED30014286-orf-1|Name=SMED30014286-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1280bp MDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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