SMED30014278

Overview
NameSMED30014278
Smed IDSMED30014278
Length (bp)2411
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30014278 (SMED30014278) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30014278 (SMED30014278) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30014278 (SMED30014278) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30014278 (SMED30014278) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014278

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymaSMED30014278SMESG000061502.1 dd_Smed_v4_12943_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30014278SMESG000061502.1 dd_Smed_v6_12943_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Alignments
SMED30014278 aligns in the following genomic locations:
Alignment LocationAlignment Score
v31.000462:143796..162342 -11628
Homology
[Close]
BLAST of SMED30014278 vs. Ensembl Human
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125])

HSP 1 Score: 68.5514 bits (166), Expect = 3.635e-11
Identity = 114/561 (20.32%), Postives = 236/561 (42.07%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+      I+   +    +  S +   Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  112 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKRKGILEIESAEVSGNSVVCSFLQ--YMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 645
[Close]
BLAST of SMED30014278 vs. Ensembl Human
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125])

HSP 1 Score: 67.781 bits (164), Expect = 6.316e-11
Identity = 117/571 (20.49%), Postives = 238/571 (41.68%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             KG L I  +++S          Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  205 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKR------------KGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 738
[Close]
BLAST of SMED30014278 vs. Ensembl Human
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125])

HSP 1 Score: 67.0106 bits (162), Expect = 1.179e-10
Identity = 117/571 (20.49%), Postives = 238/571 (41.68%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             KG L I  +++S          Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  317 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKR------------KGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 850
[Close]
BLAST of SMED30014278 vs. Ensembl Human
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125])

HSP 1 Score: 66.6254 bits (161), Expect = 1.637e-10
Identity = 117/571 (20.49%), Postives = 238/571 (41.68%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             KG L I  +++S          Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  342 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKR------------KGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 875
[Close]
BLAST of SMED30014278 vs. Ensembl Human
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125])

HSP 1 Score: 66.2402 bits (160), Expect = 1.708e-10
Identity = 117/571 (20.49%), Postives = 238/571 (41.68%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             KG L I  +++S          Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  290 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKR------------KGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 823
[Close]
BLAST of SMED30014278 vs. Ensembl Zebrafish
Match: fgd4b (FYVE, RhoGEF and PH domain containing 4b [Source:ZFIN;Acc:ZDB-GENE-110421-6])

HSP 1 Score: 62.003 bits (149), Expect = 2.231e-9
Identity = 103/505 (20.40%), Postives = 208/505 (41.19%), Query Frame = 1 
Query:  616 LANIKKELIFRTQTVTRGFQILEMIY--SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISN-DLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQED 2061
            L  I  EL+   +       +L+ ++      E   G+F   +V++ IF ++  + +FH Q    +L   +S  D    +      +   L  Y  +  +F++  +LL     +  QF      AI+  ++      +L L   +      +  +E+LL  Y + L +D+ +RS+   ++ +I       NM     + +K   E Y +L    D ++PS   I +G + K+  ++    +R +FLF +M+   +   S+    + ++ ++ +   K    ++E   P++   F++   +   E     + +   WI+    TI   + +  +F     +  + ++     + ++G   P W  + +   C  + C   F+   +   +C   G + C  C  + A L Y SN+    C +C+ ILT    +AD+ E            G  KG L I  +++S          Y D  +  QR++CV+  +    +Y Y   +D
Sbjct:  206 LFKISSELLQTERAYVSRLHLLDQVFCVRLTEEALKGSF-PVDVVKGIFSNVGSIYTFHSQFLLPDLETRMSQWDSKPRVGDVLAQLAPFLRMYAEYVKNFDSAMELLKLWMERSTQFS-----AIIQDIQSQEVCGSLTLQHHMLEPVQRVPRYEMLLKDYLKKLPEDDEDRSQAQKSLNIISMAATHSNMAIRKMENLKKLMEIYEMLGGEEDIVNPSNELIKEGQILKLAARNTSSMERYLFLFNNMLLYCVPKFSLVGQRFTVRTRVRVEGMKVLETSNE-DYPHT---FQVSGKERTLELQASSQQDKEDWIKAFQETIEIFQQKNETFKSACKEATDEVS-----KEELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCYKCSDHKASLRYDSNKLNKVCKDCYHILTG---RADAEEPVC---------GKKKGILEIEAAQVSGNSFLCGFLQYSDRTKPSQRVWCVIPQHDALVLYLYGAPQD 681
[Close]
BLAST of SMED30014278 vs. Ensembl Zebrafish
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4a [Source:ZFIN;Acc:ZDB-GENE-050420-347])

HSP 1 Score: 57.7658 bits (138), Expect = 4.750e-8
Identity = 110/571 (19.26%), Postives = 228/571 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVF-TNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNL-SMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKI----SSLYIDAIEF------QQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV-VNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNIQSS 2250
            Q L  I  EL+   +       +L+ + Y+K  E+   +    +V++ IF ++  +++FH Q    +L   +        +    Q +   L  Y  +  +F+    LL     +   FK     AI++ ++       L L   +      +  +E+LL  Y + L  ++++R     ++++I       N      + +K   E Y +L    D ++PS   I +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +  M      N +   P++   F++   +   E     + +  +WI+    TI    L+KN   +   K     +D +   +++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y  N+    C  C+ ILT +    D              +G  KG L I       SS+    +++       Q+++CV+       +Y Y   +D   Q  I +L     ++ K +       ++++   +S  A+S++   +W++ I++     +  S
Sbjct:  168 QKLYKIANELLQTEKAYVARLNLLDKVFYTKLMEEARKDTFPVDVVKSIFSNITSINAFHSQFLLPDLEKRMGEWTSTPRIGDILQKLTPFLKMYAEYVRNFDHAMDLLKQWIDRSPPFK-----AIILDIQSQEVCGNLTLQHHMLEPVQRVPRYEMLLKDYLKKLPPEHMDRRDAEKSLEIIGMAATHSNTAIRKTENLKKLLEIYEMLGEEEDIVNPSNELIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIEGMNVKETFNEDY--PHT---FQVSGKERTLELQASSKLDKESWIKAFTETI-DISLQKNETFKSAIKDTEEASDLNI--SELGKRAPRWIRDNEVTMC--MKCKEGFNAITRRRHHCRACGYVVCWKCSDYKATLEYDGNKISKVCKHCYFILTGRTDSDDR-------------EGKKKGILEIEAAQFCGSSIMCGFLQYCERNKPWQKVWCVIPEKEALVLYLYGAPQDVKAQSTIPLLGYHVEDNPKATDPPASFRLSQSKSIHSFAAESEELKQRWLKVIRMAVTGEVPES 710
[Close]
BLAST of SMED30014278 vs. Ensembl Zebrafish
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4a [Source:ZFIN;Acc:ZDB-GENE-050420-347])

HSP 1 Score: 56.6102 bits (135), Expect = 9.501e-8
Identity = 109/571 (19.09%), Postives = 228/571 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVF-TNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNL-SMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKI----SSLYIDAIEF------QQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV-VNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNIQSS 2250
            Q L  I  EL+   +       +L+ + Y+K  E+   +    +V++ IF ++  +++FH Q    +L   +        +    Q +   L  Y  +  +F+    LL     +   FK     AI++ ++       L L   +      +  +E+LL  Y + L  ++++R     ++++I       N      + +K   E Y +L    D ++PS   I +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +  M      N +   P++   F++   +   E     + +  +WI+    TI    L+KN   +   K     +D +   +++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y  N+    C  C+ ILT +    D              +G  KG L I       SS+    +++       Q+++CV+       +Y Y   +D   Q  I +L     ++ + +       ++++   +S  A+S++   +W++ I++     +  S
Sbjct:  168 QKLYKIANELLQTEKAYVARLNLLDKVFYTKLMEEARKDTFPVDVVKSIFSNITSINAFHSQFLLPDLEKRMGEWTSTPRIGDILQKLTPFLKMYAEYVRNFDHAMDLLKQWIDRSPPFK-----AIILDIQSQEVCGNLTLQHHMLEPVQRVPRYEMLLKDYLKKLPPEHMDRRDAEKSLEIIGMAATHSNTAIRKTENLKKLLEIYEMLGEEEDIVNPSNELIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIEGMNVKETFNEDY--PHT---FQVSGKERTLELQASSKLDKESWIKAFTETI-DISLQKNETFKSAIKDTEEASDLNI--SELGKRAPRWIRDNEVTMC--MKCKEGFNAITRRRHHCRACGYVVCWKCSDYKATLEYDGNKISKVCKHCYFILTGRTDSDDR-------------EGKKKGILEIEAAQFCGSSIMCGFLQYCERNKPWQKVWCVIPEKEALVLYLYGAPQDVKAQSTIPLLGYHVEDNPRATDPPASFRLSQSKSIHSFAAESEELKQRWLKVIRMAVTGEVPES 710
[Close]
BLAST of SMED30014278 vs. Ensembl Xenopus
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:100038050])

HSP 1 Score: 75.8702 bits (185), Expect = 1.195e-13
Identity = 108/512 (21.09%), Postives = 216/512 (42.19%), Query Frame = 1 
Query:  739 VIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN--QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQ-NILHSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSE--LKSPNSRKGFRL---ESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            V+ +IF ++  + SFH Q    EL + +  +  +S    +  Q +   L  Y  +  +F+   + L     +  QFK + +E     +++  +   L L   +      +  +E+LL  Y   L  D+L+R     A++LI     HS        +  K    Y +L    D + PS   I +G + K+  ++   ++R +FL  +M+                     + KFS++ ++  L++    +G ++   ++ D+   F +  + E    ++ L  TI + + +  +F   I K    + ++ +  A++G+  P W  + +   C  + C  +F+   +   +C   G + C  C  Y A L Y SN+    C +C+ IL       DS EK+  +           G   I      Y +  +  Q+++CV+  N    +Y Y   +D   Q  I +L  T ++  ++    +   +T++   ++  AD+++   KW++ IKL 
Sbjct:   31 VLNKIFSNISSIQSFHGQFLLPELESRM-KEWSISPKIGDILQKLAPFLKMYAEYVKNFDNAMETLRGWMEKSVQFKNVVEE-----IQREGKCGNLTLQHHMLGPVQRIPRYEMLLKDYLRKLPADSLDRKDAEKALELISFAATHSNTAIRKMENLKKLLSIYEMLGEEEDIVHPSNELIKEGQILKLAARNTSAQERYLFLLNNMLLYC------------------VPKFSLVGTKYTLRTKIGLEGMKVVETQNEDYPHTFQISGK-ERTLELQALRDTIAEVQQKNETFKIAIAK---ELEETPSEVAELGLRAPRWIRDNEVTMC--MKCKEQFNALTRRRHHCRACGYVVCWKCSDYKATLEYDSNKMNKVCKDCYKILRGS---IDSEEKEKKRGILEIESAEVSGNSVICSFLQ-YNEKSKPWQKVWCVIPKNEALVLYMYGAAQDVKAQATIPLLGYTVDDAPRHVDLPHSFRLTQSKSVHTFSADTEELKQKWLKMIKLA 508
[Close]
BLAST of SMED30014278 vs. Ensembl Xenopus
Match: FGD4 (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:100038050])

HSP 1 Score: 67.781 bits (164), Expect = 4.423e-11
Identity = 115/553 (20.80%), Postives = 220/553 (39.78%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIYSK-ATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN--QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQ-NILHSCNMQCDYNDFIKTQQEYNLLS-TIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L NI  EL+   +      ++L+  +     E   G+F    V+ +IF ++  + SFH Q    EL + +  +  +S    +  Q +   L  Y  +  +F+   + L     +  QFK + +E     ++    N  L    +L  ++  +  +E+LL  Y   L  D+L+R     A++LI     HS        +  K    Y +L    D + PS   I +G + K+  ++   ++R +FL  +M+   +   S+    Y ++ ++ L   K      E ++ +    F++   +   E     E     WI+                D              +  +++G+  P W  + +   C  + C  +F+   +   +C   G + C  C  Y A L Y SN+    C +C+ IL       DS EK+  +           G   I      Y +  +  Q+++CV+  N    +Y Y   +D   Q  I +L  T ++  ++    +   +T++   ++  AD+++   KW++ IKL 
Sbjct:   30 QKLHNIANELLETERAYVSRLELLQTFHDALMKEAKQGSF-PVEVLNKIFSNISSIQSFHGQFLLPELESRM-KEWSISPKIGDILQKLAPFLKMYAEYVKNFDNAMETLRGWMEKSVQFKNVVEE-----IQGKCGNLTLQHH-MLGPVQ-RIPRYEMLLKDYLRKLPADSLDRKDAEKALELISFAATHSNTAIRKMENLKKLLSIYEMLGEEEDIVHPSNELIKEGQILKLAARNTSAQERYLFLLNNMLLYCVPKFSLVGTKYTLRTKIGLEGMKV----VETQNEDYPHTFQISGKERTLELQASSEQNKEEWIK--------------VSDNYYIILIYLYILYLSSISELGLRAPRWIRDNEVTMC--MKCKEQFNALTRRRHHCRACGYVVCWKCSDYKATLEYDSNKMNKVCKDCYKILRGS---IDSEEKEKKRGILEIESAEVSGNSVICSFLQ-YNEKSKPWQKVWCVIPKNEALVLYMYGAAQDVKAQATIPLLGYTVDDAPRHVDLPHSFRLTQSKSVHTFSADTEELKQKWLKMIKLA 549
[Close]
BLAST of SMED30014278 vs. Ensembl Mouse
Match: Fgd4 (FYVE, RhoGEF and PH domain containing 4 [Source:MGI Symbol;Acc:MGI:2183747])

HSP 1 Score: 65.4698 bits (158), Expect = 2.117e-10
Identity = 117/573 (20.42%), Postives = 239/573 (41.71%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--------SKISSL--YIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y + L  +      NDA K ++ I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K    ++E + P++   F++   +   E     E +   WI+ L  +I     R  +F   I K  +   +  T  A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             +G L I        S++ S   Y++  +  Q+++CV+       +Y Y   +D   Q  I +L    ++  K++   +   +T++   +S  AD+++   KW++ I L 
Sbjct:  205 QKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEE-----IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPD--SPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNE-EYPHT---FQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVST--AELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISG---FTDSEEKKR------------RGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLA 738
[Close]
BLAST of SMED30014278 vs. Ensembl Mouse
Match: Fgd4 (FYVE, RhoGEF and PH domain containing 4 [Source:MGI Symbol;Acc:MGI:2183747])

HSP 1 Score: 65.4698 bits (158), Expect = 2.512e-10
Identity = 117/573 (20.42%), Postives = 239/573 (41.71%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--------SKISSL--YIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y + L  +      NDA K ++ I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K    ++E + P++   F++   +   E     E +   WI+ L  +I     R  +F   I K  +   +  T  A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             +G L I        S++ S   Y++  +  Q+++CV+       +Y Y   +D   Q  I +L    ++  K++   +   +T++   +S  AD+++   KW++ I L 
Sbjct:  205 QKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEE-----IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPD--SPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNE-EYPHT---FQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVST--AELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISG---FTDSEEKKR------------RGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLA 738
[Close]
BLAST of SMED30014278 vs. Ensembl Mouse
Match: Fgd4 (FYVE, RhoGEF and PH domain containing 4 [Source:MGI Symbol;Acc:MGI:2183747])

HSP 1 Score: 65.4698 bits (158), Expect = 2.512e-10
Identity = 117/573 (20.42%), Postives = 239/573 (41.71%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--------SKISSL--YIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y + L  +      NDA K ++ I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K    ++E + P++   F++   +   E     E +   WI+ L  +I     R  +F   I K  +   +  T  A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             +G L I        S++ S   Y++  +  Q+++CV+       +Y Y   +D   Q  I +L    ++  K++   +   +T++   +S  AD+++   KW++ I L 
Sbjct:  205 QKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEE-----IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPD--SPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNE-EYPHT---FQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVST--AELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISG---FTDSEEKKR------------RGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLA 738
[Close]
BLAST of SMED30014278 vs. UniProt/SwissProt
Match: sp|Q96M96|FGD4_HUMAN (FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2)

HSP 1 Score: 67.781 bits (164), Expect = 3.033e-10
Identity = 117/571 (20.49%), Postives = 238/571 (41.68%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQNIL-HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--SKISS--------LYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y   L  D+L+ +    ++++I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K     +E + P++   F++   +   E       +   WI+ L  TI     R  +F   I K  N I+ S+   A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             KG L I  +++S          Y++  +  Q+ +CV+       +Y Y   +D   Q  I +L    +   +++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  205 QKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEE-----IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNE-EYPHT---FQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD-NDIH-SEVSTAELGKRAPRWIRDNEVTMC--MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG---FTDSEEKKR------------KGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLA 738
[Close]
BLAST of SMED30014278 vs. UniProt/SwissProt
Match: sp|O88387|FGD4_RAT (FYVE, RhoGEF and PH domain-containing protein 4 OS=Rattus norvegicus OX=10116 GN=Fgd4 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 6.672e-10
Identity = 123/607 (20.26%), Postives = 251/607 (41.35%), Query Frame = 1 
Query:  529 QPEIYASLDSSSSDIDNQSLHSTNSF-------SQDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--------SKISSL--YIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            +P I A L    + +  + L+  +          Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y + L  +      NDA K ++ I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K    ++E + P++   F++   +   E     E +   WI+ L  +I     R  +F   I K  +   +  T  A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++     A+S EK+             +G L I        S++ S   Y++  +  Q+++CV+       +Y Y   +D   Q  I +L    ++  K++   +   +T++   +S  ADS++   KW++ I L 
Sbjct:  171 EPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATELLLTERAYVSRLNLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAVELVKNMTERVPQFKSVTEE-----IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDA--PDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNE-EYPHT---FQVSGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVST--AELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIMSG---FAESEEKKR------------RGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYIVDDMPKSADLPHSFKLTQSKSVHSFAADSEELKQKWLKIILLA 738
[Close]
BLAST of SMED30014278 vs. UniProt/SwissProt
Match: sp|Q91ZT5|FGD4_MOUSE (FYVE, RhoGEF and PH domain-containing protein 4 OS=Mus musculus OX=10090 GN=Fgd4 PE=1 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 1.757e-9
Identity = 117/573 (20.42%), Postives = 239/573 (41.71%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMI-YSKATEKF-AGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTI--------SKISSL--YIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ + Y K  E+   G+F  + ++ +IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +   F+   +L+ ++  +  QFK + +E     +++     +L L   +      +  +E+LL  Y + L  +      NDA K ++ I     HS +      +  K  + Y +L    D ++PS   I +G + K+  ++   ++R +FLF +M+   +   S+    + ++ ++ +   K    ++E + P++   F++   +   E     E +   WI+ L  +I     R  +F   I K  +   +  T  A++G   P W  + +   C  + C   F+   +   +C   G + C  C  Y A L Y   +    C +C+ I++      DS EK+             +G L I        S++ S   Y++  +  Q+++CV+       +Y Y   +D   Q  I +L    ++  K++   +   +T++   +S  AD+++   KW++ I L 
Sbjct:  205 QKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSF-PAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDIL--------QKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEE-----IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPD--SPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNE-EYPHT---FQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVST--AELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISG---FTDSEEKKR------------RGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLA 738
[Close]
BLAST of SMED30014278 vs. TrEMBL
Match: A0A1B8Y376 (Uncharacterized protein OS=Xenopus tropicalis OX=8364 GN=XENTR_v90027190mg PE=4 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 2.001e-16
Identity = 122/553 (22.06%), Postives = 230/553 (41.59%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIYSK-ATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN--QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQ-NILHSCNMQCDYNDFIKTQQEYNLLS-TIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L NI  EL+   +      ++L+  +     E   G+F    V+ +IF ++  + SFH Q    EL + +  +  +S    +  Q +   L  Y  +  +F+   + L     +  QFK + +E     +++  +   L L   +      +  +E+LL  Y   L  D+L+R     A++LI     HS        +  K    Y +L    D + PS   I +G + K+  ++   ++R +FL  +M+   +   S+    Y ++ ++ L   K      E ++ +    F++   +   E     E     WI+ L  TI + + +  +F   I K       S+  RA++G+  P W  + +   C  + C  +F+   +   +C   G + C  C  Y A L Y SN+    C +C+ IL       DS EK+  +           G   I      Y +  +  Q+++CV+  N    +Y Y   +D   Q  I +L  T ++  ++    +   +T++   ++  AD+++   KW++ IKL 
Sbjct:   15 QKLHNIANELLETERAYVSRLELLQTFHDALMKEAKQGSF-PVEVLNKIFSNISSIQSFHGQFLLPELESRM-KEWSISPKIGDILQKLAPFLKMYAEYVKNFDNAMETLRGWMEKSVQFKNVVEE-----IQREGKCGNLTLQHHMLGPVQRIPRYEMLLKDYLRKLPADSLDRKDAEKALELISFAATHSNTAIRKMENLKKLLSIYEMLGEEEDIVHPSNELIKEGQILKLAARNTSAQERYLFLLNNMLLYCVPKFSLVGTKYTLRTKIGLEGMKV----VETQNEDYPHTFQISGKERTLELQASSEQNKEEWIKALRDTIAEVQQKNETFKIAIAKELEE-TPSEVSRAELGLRAPRWIRDNEVTMC--MKCKEQFNALTRRRHHCRACGYVVCWKCSDYKATLEYDSNKMNKVCKDCYKILRGS---IDSEEKEKKRGILEIESAEVSGNSVICSFLQ-YNEKSKPWQKVWCVIPKNEALVLYMYGAAQDVKAQATIPLLGYTVDDAPRHVDLPHSFRLTQSKSVHTFSADTEELKQKWLKMIKLA 549
[Close]
BLAST of SMED30014278 vs. TrEMBL
Match: A0A1L8GQD4 (Uncharacterized protein OS=Xenopus laevis OX=8355 GN=XELAEV_18019762mg PE=4 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 9.456e-14
Identity = 123/581 (21.17%), Postives = 238/581 (40.96%), Query Frame = 1 
Query:  520 SSLQPEIYASLDSSSSDID-NQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIYSK-ATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISN-DLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLD-DNLERSRINDAIKLIQ-NILHSCNMQCDYNDFIKTQQEYNLLS-TIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSF-NVVNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            ++L P   A  D SS +I   +   +  +  Q L NI  EL+   +       +L+  +     E   G+F    V+ +IF ++  + SFH Q    EL   +    +   +    Q +   L  Y  +  +F+   + L     +  QFK + +E   I  +   +N  L    +L  ++  +  +E+LL  Y   L  D+L+R     +++LI     HS     +  +  K    Y +L    D + PS   I +G + K+  ++   ++R +FL  +M+            K   ++ + +    ++  E ++ +    F++   +   E     E     WI+ L  TI + + +  +F   I K     + ++  RA++G+  P W  + +   C  + C  +F+   +   +C   G + C  C  Y A L Y  N+    C +C+ IL       DS EK+  +           G   I      Y +  +  Q+++CV+  N    +Y Y   +D   Q  I +L    ++  ++    +   +T++   ++  AD+++   KW++ IKL 
Sbjct:  173 TTLSPTEEALEDISSINITLAEPSDAKETNEQKLHNIANELLETERAYVSRLALLQTFHDALMKEAKQGSF-PVEVLNKIFSNISSIQSFHGQFLLPELETRMKEWSVTPKIGDILQKLAPFLKMYAEYVKNFDNAMETLRGWMEKSVQFKNVLEE---IQREGKCDNLTLQH-HMLGPVQ-RIPRYEMLLKDYLRKLPADSLDRKDAEKSLELISFAATHSNTAIRNMENLKKLLSIYEMLGEEEDIVHPSNELIKEGQILKLAARNTSAQERYLFLLNNMLLYCVPKFSLVGTKYTLRIRIGLEGMKVV--ETQNEDYPHTFQISGKERTLELQASSEQNKEEWIKALRDTIAEVQHKNETFKIAIAKELEE-SPAEVSRAELGLRAPRWIRDNEVTMC--MKCKEQFNALTRRRHHCRACGYVVCWKCSDYKALLEYDGNKMNKVCKDCYKILRGS---IDSEEKEKKRGILEIESAEVSGNSLICSFLQ-YNEKSKPCQKVWCVIPKNEALVLYMYGAAQDVKAQATIPLLGYMVDDAPRHVDLPHSFRLTQSKSVHTFSADTEELKQKWLKMIKLA 738
[Close]
BLAST of SMED30014278 vs. TrEMBL
Match: W5N0M9 (FYVE, RhoGEF and PH domain containing 2 OS=Lepisosteus oculatus OX=7918 GN=FGD2 PE=4 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.491e-12
Identity = 115/570 (20.18%), Postives = 237/570 (41.58%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIYSKA---TEKFAGNFEKSNVIERIFKDLKCMSSFHQLY-----QAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLI-QNILHSCNMQCDYNDFIKTQQEYNLLSTIDPL-SPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPR-NCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQ-------DRKADSIEXXXXXXXX------------XXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVLNSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNVVNITKNGVKYSIEADSQDEALKWIQSI 2217
            + L  I KEL+   +       +L+ ++        + AG+F + +V+++IF ++  +  FH L+     Q  ++    N     ++   Q +   L  Y  +  SF+    L+S+   +  +F+ I    + I  ++ S N AL    +L  ++  +  +E+LL  Y + L + + +R+    ++++I +   HS +   D     K  + Y +L   + +  PS + + +G VQK+  +   ++   +FLF +M+   +   S+    Y I+ ++++   +   +N +++ P+S   F +       EF +  + +   WI+     I Q + +  SF   I+     + +    R ++G   P W  +   + C  + CS  F+     R +C   G + C  C  Y A L Y +N+    C EC+  L  Q       D+K   +EK+  +                Q  G  +GW  I +   L                    +Y Y   +D   Q  I +L       +  S+     ++++   ++  A+S+++  +W++ I
Sbjct:    5 EKLFKIAKELLETEEAYVSRLHLLDQVFYAELLNEARTAGSFPE-DVVKQIFSNISSIYQFHGLFLLPELQRRMDEWCKNPRIGDVL---QKVAPFLKMYGQYVMSFDKAMHLISTWMEKSTRFEEII---LDIQKREISGNLALQ-HHMLEPVQ-RVPRYEMLLKDYLKKLPEGSPDRADAEKSLEIIFEAAKHSNSAIADMERLEKLWEVYEMLGMDEEMVDPSNKLLQEGPVQKISFRRNTLKDSHLFLFNNMLLYCVPKFSLGDRRYMIRARVDMDCMQVKELN-DVEFPHS---FLVSGKLRTLEFQIRSQEDMEAWIKACQQAIDQNEKKTESFKHAISSLSQDLQELTVDRQELGKRAPQWIRDNLVSMC--MRCSDPFNAIIRRRHHCRACGYVVCWKCSDYKAALLYDANRMNRVCRECYSALEGQADSREREDKKRGILEKEAAEVSERSLMCSFLTIMDRQGKGGTRGWFVIPRDEPL-------------------ILYMYAAPQDVKAQTTIPLLGYQVKEQLPGSNKCTFQLSQSKQVFTFVAESEEQRDRWVEII 540
[Close]
BLAST of SMED30014278 vs. TrEMBL
Match: A0A504YG18 (FYVE RhoGEF and PH domain-containing protein 2 (Fragment) OS=Fasciola gigantica OX=46835 GN=FGIG_09716 PE=4 SV=1)

HSP 1 Score: 81.6481 bits (200), Expect = 3.907e-12
Identity = 93/412 (22.57%), Postives = 177/412 (42.96%), Query Frame = 1 
Query:  625 IKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNA----VISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL---DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSPSIRFI----HKGLVQKVCRQSFCMR--QRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSII--NSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSY 1815
            I +E++   +      ++L++I  +   +F+   + SN+ E IF+D+  +   HQ+   +L+     +  N LP + V   +V    LN YK F   +      L S ++ D +F  +     ++   +  E    ++  +   +  SL  F +L  +  E L   D N+E   +  A+K++ ++L     +    D I   Q     + ID    + R I     +G  +K+ R+S   R   R +FLF   + IT  +     Y++K +L LS    S +  + E+ +P+    FR+++ + C E     E E   W + + S I + + RK+S           I+ +D +      +   W  +E++  C    C  +F       +C   G ++C +C  Y A ++Y
Sbjct:  131 IFEEMVHFERRFLETLRLLKLISDEVNSRFSSR-DASNLRE-IFRDIPSLYQLHQIICQKLDELQPDISGNLLPSAFVDDKEV--PFLNIYKSFMCRYANNYPALVSHWNGDKEFAALCRN--ILQTSKYEEQRIQDVCGMYFGVHCSLTRFRLLFTKLKEALSPGDKNMEN--VKKALKVLNDLLQISEGEVLRQDKISDAQ--VAFAKIDGREMNFRHIPPLLREGPCKKIPRRSSHKRNLDRHLFLFAGYLVITEVANPIGRYQVKSELLLSGMNLSEVSEDDEISTPHC---FRIKATELCVELAFASEKEKTEWWDDIQSAISEERDRKDS--------IIPISSTDKIEGTTATSAAEWVKDEQSTMCA--ECYAQFTVLNRRHHCRACGKVFCGSCSAYRAPIAY 519
[Close]
BLAST of SMED30014278 vs. TrEMBL
Match: A0A4Z2DQC2 (FYVE, RhoGEF and PH domain-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_010080 PE=4 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 5.237e-12
Identity = 85/382 (22.25%), Postives = 157/382 (41.10%), Query Frame = 1 
Query:  721 NFEKSNVIERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARY-SEHLDDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLS---PSIRFIH-KGLVQKVCRQSFCMR--QRMIFLFTHMIFITGKSIQFHTYKIKHQLNLS-MCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLS-YSNQFGSTC 1839
            +F+ ++VI  +FKD+  +   H+      ++  + DL L   FT+      LN YK F   +    +  S +YS + + + I     ++   Q  E    N+P +   +  +L  ++ L+ R     L  + E   +  A    +N+L     +    +  K Q     L  +D L      I  +H +G  +K+ R+S   R   R +FLF+  + +T        +++K ++ L+ M  + + + E    N    FR+++ + C E     E E   W  +L   I     ++N+ + +  K    IN       D+G     W  +E +  C   NC   F       +C   G ++C +C  Y A L+ Y  ++   C
Sbjct:  130 SFKDNSVISGMFKDIPSLFKLHEHLTDSFDSCNTEDLILPTAFTSDKETQILNIYKSFLCRYATNFKPFSEMYSTNDELQSICKG--IVANSQYEEQRIQNVPGMFYGVSTALPRYKDLIYRLKGTMLSSDPEYVSVTKAWNFFKNLLDRSEQEIILQE--KMQNAREALDKLDGLRVKYTQIPLLHLEGPAKKLPRRSVHRRLLDRYLFLFSEYLVMTELPNSVGRHQVKSEIRLAGMTLWEVKDDE--EINVEHCFRIKAKELCVEVAFSNEDEKMLWWHELQQAIDSESNKQNNNNFEEKKSLIGIN-------DLGEVAAQWVKDESSTMCT--NCCTEFTTLNRRHHCRACGKVFCGSCSAYKAPLAFYGGKYQRVC 496
[Close]
BLAST of SMED30014278 vs. Ensembl Cavefish
Match: ENSAMXT00000014177.2 (FYVE, RhoGEF and PH domain-containing protein 6-like [Source:NCBI gene;Acc:103024376])

HSP 1 Score: 72.7886 bits (177), Expect = 1.063e-12
Identity = 107/479 (22.34%), Postives = 203/479 (42.38%), Query Frame = 1 
Query:  502 NEKSIYSSLQPEIYASLDSSSSDIDNQSLHSTNSFSQD------LANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSA---------LNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSE---NYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSR-INDAIKLIQNILHSCNMQCDYND-FIK-TQQEYNLLSTIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFN----RINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGS-TCNECFDIL 1860
            NE ++Y  +       +DS S   ++ + +S    SQ+      LA+I +E++   +      ++L + + KA E  A    K+ + +RI   +  + S  QLY  ELN+ +  +L   +   N+    A         L  Y  +   F+    LL     ++  F      A V+   ++S    N A+   ++L  ++  L  +++LL+ Y ++L++N    +   DA+KL++++ +  N      D F K  Q +Y+L+   + + P    + +G + K+ R+   M+ RM FLF   +  T   +Q   YK+ ++L+L+  K S  + E      +    +ES +          T    W+E +++ I       N + +K+  + +         DTV A +G   P W  + +   C    C F     +   +C   G + C+ C      L Y        C++CF+ L
Sbjct:  577 NESNVYEDILSSDEEEIDSGSEVEEDSNSYSDKDQSQNDAKNTKLAHIAREIMSSEKVFVEVLKLLHIKFRKAVED-ASQGGKAVIDDRILNQI--LFSLPQLY--ELNSNLLRELEERVANWNEHSGVADIFLKKGPYLKMYSSYICEFDKNVALLEEQCRKNPAF------AKVVREFESSPCCANLAVKH-YMLKPVQ-RLPQYQLLLSDYVKNLNENSPHYKDTQDALKLVKDVANHANETMRKGDNFQKLIQVQYSLMGHHEIVKPGRTLLKEGTLMKLSRK--VMQPRMFFLFNDTLLYT-TPLQTGQYKLNNELSLAGMKVSKPSQE----GHQNELNIESVERSFILSASSPTARDEWLEAISAAI-------NDYTKKMISFGSSRSPEEGGKDTVDAQLGSKAPIWIPDLRATMCMICTCEFTLTWRR--HHCRACGKVVCQACSTNKYPLEYLKYHPERVCDQCFETL 1026
[Close]
BLAST of SMED30014278 vs. Ensembl Cavefish
Match: ENSAMXT00000032138.1 (FYVE, RhoGEF and PH domain-containing protein 4-like [Source:NCBI gene;Acc:103046578])

HSP 1 Score: 55.4546 bits (132), Expect = 2.071e-7
Identity = 86/450 (19.11%), Postives = 184/450 (40.89%), Query Frame = 1 
Query:  574 DNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQ 1869
            ++ S+    +  Q L  I  EL+   +       +L+ ++ +K  E+        +V++ IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +  +F+   +LL     +  QFK     A +  +++     +L+L   +      +  +E+LL  Y + L  D+++R     ++++I       N     ++ +K   E Y +L    D ++ S  FI +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +   K +   +E   P++   F++   +   E     + +   WI+    TI +   +KN   +  +K    ++ S+     +G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+ ILT  
Sbjct:  134 EDTSMEHKETNEQKLYKIANELLQTEKAYVARLNLLDQVFCAKLMEEAGKGIFPVDVVKNIFSNISSINAFHSQFLLPDLEKRMGEWESTPRIGDIL--------QKLTPFLKMYAEYVRNFDKAMELLKQWTDRSPQFK-----ATIQEIQKQEVCGSLSLQHHMLEPVQRVPRYEMLLKDYLKKLPQDHVDRRDAEKSLEIIATAATHSNTAIRKSENLKKLLEIYEMLGEEEDIVNASNEFIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIDGMKVAETYNE-DYPHT---FQVSGKERTLELQASTQQDKEDWIKAFQETI-EIFHQKNETFKTASKEVEEVSISE-----LGKRAPRWIRDNEVTMC--MKCREPFNALTRRRHHCRACGYVVCWKCSDNKASLEYDGNKMNKVCRDCYSILTGH 558
[Close]
BLAST of SMED30014278 vs. Ensembl Cavefish
Match: ENSAMXT00000054774.1 (FYVE, RhoGEF and PH domain-containing protein 4-like [Source:NCBI gene;Acc:103046578])

HSP 1 Score: 55.4546 bits (132), Expect = 2.119e-7
Identity = 86/450 (19.11%), Postives = 184/450 (40.89%), Query Frame = 1 
Query:  574 DNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQ 1869
            ++ S+    +  Q L  I  EL+   +       +L+ ++ +K  E+        +V++ IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +  +F+   +LL     +  QFK     A +  +++     +L+L   +      +  +E+LL  Y + L  D+++R     ++++I       N     ++ +K   E Y +L    D ++ S  FI +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +   K +   +E   P++   F++   +   E     + +   WI+    TI +   +KN   +  +K    ++ S+     +G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+ ILT  
Sbjct:  117 EDTSMEHKETNEQKLYKIANELLQTEKAYVARLNLLDQVFCAKLMEEAGKGIFPVDVVKNIFSNISSINAFHSQFLLPDLEKRMGEWESTPRIGDIL--------QKLTPFLKMYAEYVRNFDKAMELLKQWTDRSPQFK-----ATIQEIQKQEVCGSLSLQHHMLEPVQRVPRYEMLLKDYLKKLPQDHVDRRDAEKSLEIIATAATHSNTAIRKSENLKKLLEIYEMLGEEEDIVNASNEFIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIDGMKVAETYNE-DYPHT---FQVSGKERTLELQASTQQDKEDWIKAFQETI-EIFHQKNETFKTASKEVEEVSISE-----LGKRAPRWIRDNEVTMC--MKCREPFNALTRRRHHCRACGYVVCWKCSDNKASLEYDGNKMNKVCRDCYSILTGH 541
[Close]
BLAST of SMED30014278 vs. Ensembl Cavefish
Match: ENSAMXT00000055861.1 (FYVE, RhoGEF and PH domain-containing protein 4-like [Source:NCBI gene;Acc:103046578])

HSP 1 Score: 54.6842 bits (130), Expect = 4.287e-7
Identity = 105/576 (18.23%), Postives = 235/576 (40.80%), Query Frame = 1 
Query:  574 DNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQDRKADSIEXXXX----XXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV-VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            ++ S+    +  Q L  I  EL+   +       +L+ ++ +K  E+        +V++ IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +  +F+   +LL     +  QFK     A +  +++     +L+L   +      +  +E+LL  Y + L  D+++R     ++++I       N     ++ +K   E Y +L    D ++ S  FI +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +   K +   +E   P++   F++   +   E     + +   WI+    TI +   +KN   +  +K    ++ S+     +G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+ ILT      +   K+      +  +     +  G+L        Y +  +  Q+++CV+       +Y Y   +D   Q  I +L  + ++  + +       ++++   +S  A+S++   +W++ I+L 
Sbjct:  253 EDTSMEHKETNEQKLYKIANELLQTEKAYVARLNLLDQVFCAKLMEEAGKGIFPVDVVKNIFSNISSINAFHSQFLLPDLEKRMGEWESTPRIGDIL--------QKLTPFLKMYAEYVRNFDKAMELLKQWTDRSPQFK-----ATIQEIQKQEVCGSLSLQHHMLEPVQRVPRYEMLLKDYLKKLPQDHVDRRDAEKSLEIIATAATHSNTAIRKSENLKKLLEIYEMLGEEEDIVNASNEFIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIDGMKVAETYNE-DYPHT---FQVSGKERTLELQASTQQDKEDWIKAFQETI-EIFHQKNETFKTASKEVEEVSISE-----LGKRAPRWIRDNEVTMC--MKCREPFNALTRRRHHCRACGYVVCWKCSDNKASLEYDGNKMNKVCRDCYSILTGHSESEEKEGKKKGILEIEAAQFSGSSIMCGFLQ-------YCEKNKPWQKVWCVIPEKEALVLYLYGAPQDVKAQSTIPLLGYSVDDAARPADPPASFRLSQSKSVHSFAAESEELKQRWLRVIRLA 796
[Close]
BLAST of SMED30014278 vs. Ensembl Cavefish
Match: ENSAMXT00000030769.1 (FYVE, RhoGEF and PH domain-containing protein 4-like [Source:NCBI gene;Acc:103046578])

HSP 1 Score: 54.299 bits (129), Expect = 4.389e-7
Identity = 86/450 (19.11%), Postives = 184/450 (40.89%), Query Frame = 1 
Query:  574 DNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH----------QLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHL-DDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQE-YNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTNQ 1869
            ++ S+    +  Q L  I  EL+   +       +L+ ++ +K  E+        +V++ IF ++  +++FH          ++ + E    I + L        Q +   L  Y  +  +F+   +LL     +  QFK     A +  +++     +L+L   +      +  +E+LL  Y + L  D+++R     ++++I       N     ++ +K   E Y +L    D ++ S  FI +G + K+  ++     R +FLF +M+   +   S+    + ++ ++ +   K +   +E   P++   F++   +   E     + +   WI+    TI +   +KN   +  +K    ++ S+     +G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+ ILT  
Sbjct:  269 EDTSMEHKETNEQKLYKIANELLQTEKAYVARLNLLDQVFCAKLMEEAGKGIFPVDVVKNIFSNISSINAFHSQFLLPDLEKRMGEWESTPRIGDIL--------QKLTPFLKMYAEYVRNFDKAMELLKQWTDRSPQFK-----ATIQEIQKQEVCGSLSLQHHMLEPVQRVPRYEMLLKDYLKKLPQDHVDRRDAEKSLEIIATAATHSNTAIRKSENLKKLLEIYEMLGEEEDIVNASNEFIKEGHILKLAARNTSAMDRYLFLFNNMLLYCVPKFSLVGQKFTVRTRIGIDGMKVAETYNE-DYPHT---FQVSGKERTLELQASTQQDKEDWIKAFQETI-EIFHQKNETFKTASKEVEEVSISE-----LGKRAPRWIRDNEVTMC--MKCREPFNALTRRRHHCRACGYVVCWKCSDNKASLEYDGNKMNKVCRDCYSILTGH 693
[Close]
BLAST of SMED30014278 vs. Ensembl Medaka
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:101161238])

HSP 1 Score: 65.0846 bits (157), Expect = 1.941e-10
Identity = 111/561 (19.79%), Postives = 224/561 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVF-TNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV-RADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTN----QDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV---VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ ++ SK  E+        +V++ IF ++  + +FH Q    +L   +        +    Q     L  Y  +  +F+   +LL     +  QFK     AI++ ++       L L   +      +  +E+LL  Y + L D     R  DA K ++ I     HS +      +  K  + Y +L    D ++PS  FI +G + K+  ++    +R +FLF +M+   +   S+    Y ++ ++ +      +   E  + +    F++   +   E     E +   WI+    TI         F +K   + N + + + V +A++G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+  LT     +D K +      I+  +     +  G+L  S    L+       Q+++CV+       +Y Y   +D   Q  I ++   ++ D  N S +     +++++   +   A++ +   +W++ I++ 
Sbjct:  147 QKLFKIASELLHTEKAYVARLHLLDQVFCSKLMEEANKGTFPVDVVKNIFSNISSIHAFHSQFLLPDLEKRMDEWASTPRIGDILQRFTPFLKMYAEYVKNFDNAMELLKQWSDRSPQFK-----AIILEIQSQEVCGCLTLQHHMLEPVQRIPRYEMLLKDYLKKLPDKHPDER--DAQKSLEIIATAATHSNSAIRKSENLKKLMEIYEMLGEEEDIVNPSNEFIREGHILKLAARNTSAMERYLFLFNNMLLYCVPKFSLGGPKYTVRTRIGIE----GMTVRETSNEDYPHTFQVSGKERTLELQASSEQDKAGWIKAFQETI-------EVFQQKNESFKNALKEVEEVSKAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGYVVCWKCSDNKAPLEYDGNKMNKVCRDCYSTLTGERVTEDGKKERKGILEIEAAKFTESSIICGFLQHSDKGKLW-------QKVWCVIPEKDSLVLYLYGAPQDVKAQGSIPLV--GYSVDESNRSTDPSHSFHLSQSKSVHYFAAENDEAKQRWLKVIRVA 678
[Close]
BLAST of SMED30014278 vs. Ensembl Medaka
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:101161238])

HSP 1 Score: 64.3142 bits (155), Expect = 3.995e-10
Identity = 111/561 (19.79%), Postives = 224/561 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN-QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV-RADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTN----QDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV---VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ ++ SK  E+        +V++ IF ++  + +FH Q    +L   +        +    Q     L  Y  +  +F+   +LL     +  QFK     AI++ ++       L L   +      +  +E+LL  Y + L D     R  DA K ++ I     HS +      +  K  + Y +L    D ++PS  FI +G + K+  ++    +R +FLF +M+   +   S+    Y ++ ++ +      +   E  + +    F++   +   E     E +   WI+    TI         F +K   + N + + + V +A++G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+  LT     +D K +      I+  +     +  G+L  S    L+       Q+++CV+       +Y Y   +D   Q  I ++   ++ D  N S +     +++++   +   A++ +   +W++ I++ 
Sbjct:  171 QKLFKIASELLHTEKAYVARLHLLDQVFCSKLMEEANKGTFPVDVVKNIFSNISSIHAFHSQFLLPDLEKRMDEWASTPRIGDILQRFTPFLKMYAEYVKNFDNAMELLKQWSDRSPQFK-----AIILEIQSQEVCGCLTLQHHMLEPVQRIPRYEMLLKDYLKKLPDKHPDER--DAQKSLEIIATAATHSNSAIRKSENLKKLMEIYEMLGEEEDIVNPSNEFIREGHILKLAARNTSAMERYLFLFNNMLLYCVPKFSLGGPKYTVRTRIGIE----GMTVRETSNEDYPHTFQVSGKERTLELQASSEQDKAGWIKAFQETI-------EVFQQKNESFKNALKEVEEVSKAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGYVVCWKCSDNKAPLEYDGNKMNKVCRDCYSTLTGERVTEDGKKERKGILEIEAAKFTESSIICGFLQHSDKGKLW-------QKVWCVIPEKDSLVLYLYGAPQDVKAQGSIPLV--GYSVDESNRSTDPSHSFHLSQSKSVHYFAAENDEAKQRWLKVIRVA 702
[Close]
BLAST of SMED30014278 vs. Ensembl Medaka
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:101161238])

HSP 1 Score: 63.929 bits (154), Expect = 5.752e-10
Identity = 111/561 (19.79%), Postives = 224/561 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN-QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV-RADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTN----QDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV---VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ ++ SK  E+        +V++ IF ++  + +FH Q    +L   +        +    Q     L  Y  +  +F+   +LL     +  QFK     AI++ ++       L L   +      +  +E+LL  Y + L D     R  DA K ++ I     HS +      +  K  + Y +L    D ++PS  FI +G + K+  ++    +R +FLF +M+   +   S+    Y ++ ++ +      +   E  + +    F++   +   E     E +   WI+    TI         F +K   + N + + + V +A++G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+  LT     +D K +      I+  +     +  G+L  S    L+       Q+++CV+       +Y Y   +D   Q  I ++   ++ D  N S +     +++++   +   A++ +   +W++ I++ 
Sbjct:  309 QKLFKIASELLHTEKAYVARLHLLDQVFCSKLMEEANKGTFPVDVVKNIFSNISSIHAFHSQFLLPDLEKRMDEWASTPRIGDILQRFTPFLKMYAEYVKNFDNAMELLKQWSDRSPQFK-----AIILEIQSQEVCGCLTLQHHMLEPVQRIPRYEMLLKDYLKKLPDKHPDER--DAQKSLEIIATAATHSNSAIRKSENLKKLMEIYEMLGEEEDIVNPSNEFIREGHILKLAARNTSAMERYLFLFNNMLLYCVPKFSLGGPKYTVRTRIGIE----GMTVRETSNEDYPHTFQVSGKERTLELQASSEQDKAGWIKAFQETI-------EVFQQKNESFKNALKEVEEVSKAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGYVVCWKCSDNKAPLEYDGNKMNKVCRDCYSTLTGERVTEDGKKERKGILEIEAAKFTESSIICGFLQHSDKGKLW-------QKVWCVIPEKDSLVLYLYGAPQDVKAQGSIPLV--GYSVDESNRSTDPSHSFHLSQSKSVHYFAAENDEAKQRWLKVIRVA 840
[Close]
BLAST of SMED30014278 vs. Ensembl Medaka
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:101161238])

HSP 1 Score: 63.929 bits (154), Expect = 5.997e-10
Identity = 111/561 (19.79%), Postives = 224/561 (39.93%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVF-TNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV-RADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTN----QDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV---VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ ++ SK  E+        +V++ IF ++  + +FH Q    +L   +        +    Q     L  Y  +  +F+   +LL     +  QFK     AI++ ++       L L   +      +  +E+LL  Y + L D     R  DA K ++ I     HS +      +  K  + Y +L    D ++PS  FI +G + K+  ++    +R +FLF +M+   +   S+    Y ++ ++ +      +   E  + +    F++   +   E     E +   WI+    TI         F +K   + N + + + V +A++G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+  LT     +D K +      I+  +     +  G+L  S    L+       Q+++CV+       +Y Y   +D   Q  I ++   ++ D  N S +     +++++   +   A++ +   +W++ I++ 
Sbjct:  307 QKLFKIASELLHTEKAYVARLHLLDQVFCSKLMEEANKGTFPVDVVKNIFSNISSIHAFHSQFLLPDLEKRMDEWASTPRIGDILQRFTPFLKMYAEYVKNFDNAMELLKQWSDRSPQFK-----AIILEIQSQEVCGCLTLQHHMLEPVQRIPRYEMLLKDYLKKLPDKHPDER--DAQKSLEIIATAATHSNSAIRKSENLKKLMEIYEMLGEEEDIVNPSNEFIREGHILKLAARNTSAMERYLFLFNNMLLYCVPKFSLGGPKYTVRTRIGIE----GMTVRETSNEDYPHTFQVSGKERTLELQASSEQDKAGWIKAFQETI-------EVFQQKNESFKNALKEVEEVSKAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGYVVCWKCSDNKAPLEYDGNKMNKVCRDCYSTLTGERVTEDGKKERKGILEIEAAKFTESSIICGFLQHSDKGKLW-------QKVWCVIPEKDSLVLYLYGAPQDVKAQGSIPLV--GYSVDESNRSTDPSHSFHLSQSKSVHYFAAENDEAKQRWLKVIRVA 838
[Close]
BLAST of SMED30014278 vs. Ensembl Medaka
Match: fgd4a (FYVE, RhoGEF and PH domain containing 4 [Source:NCBI gene;Acc:101161238])

HSP 1 Score: 63.1586 bits (152), Expect = 8.991e-10
Identity = 112/561 (19.96%), Postives = 226/561 (40.29%), Query Frame = 1 
Query:  610 QDLANIKKELIFRTQTVTRGFQILEMIY-SKATEKFAGNFEKSNVIERIFKDLKCMSSFH-QLYQAELNAVISNDLPLSMVFTN-QVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNIL----HSCNMQCDYNDFIKTQQEYNLLSTI-DPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIF--ITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV-RADIGVTEPYWQLEEKTNFCNGLNCSFRFDP-NKPPRNCSGDGLLYCENCLGYSAFLSY-SNQFGSTCNECFDILTN----QDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL--NSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNV---VNITKNGVKYSIEADSQDEALKWIQSIKLC 2226
            Q L  I  EL+   +       +L+ ++ SK  E+        +V++ IF ++  + +FH Q    +L   +        +    Q     L  Y  +  +F+   +LL     +  QFK     AI++ ++       L L   +      +  +E+LL  Y + L D     R  DA K ++ I     HS +      +  K  + Y +L    D ++PS  FI +G + K+  ++    +R +FLF +M+   +   S+    Y ++ ++ +        ++E   P++   F++   +   E     E +   WI+    TI         F +K   + N + + + V +A++G   P W  + +   C  + C   F+   +   +C   G + C  C    A L Y  N+    C +C+  LT     +D K +      I+  +     +  G+L  S    L+       Q+++CV+       +Y Y   +D   Q  I ++   ++ D  N S +     +++++   +   A++ +   +W++ I++ 
Sbjct:  314 QKLFKIASELLHTEKAYVARLHLLDQVFCSKLMEEANKGTFPVDVVKNIFSNISSIHAFHSQFLLPDLEKRMDEWASTPRIGDILQRFTPFLKMYAEYVKNFDNAMELLKQWSDRSPQFK-----AIILEIQSQEVCGCLTLQHHMLEPVQRIPRYEMLLKDYLKKLPDKHPDER--DAQKSLEIIATAATHSNSAIRKSENLKKLMEIYEMLGEEEDIVNPSNEFIREGHILKLAARNTSAMERYLFLFNNMLLYCVPKFSLGGPKYTVRTRIGIEGMTVRETSNE-DYPHT---FQVSGKERTLELQASSEQDKAGWIKAFQETI-------EVFQQKNESFKNALKEVEEVSKAELGKRAPRWIRDNEVTMC--MKCKESFNALTRRRHHCRACGYVVCWKCSDNKAPLEYDGNKMNKVCRDCYSTLTGERVTEDGKKERKGILEIEAAKFTESSIICGFLQHSDKGKLW-------QKVWCVIPEKDSLVLYLYGAPQDVKAQGSIPLV--GYSVDESNRSTDPSHSFHLSQSKSVHYFAAENDEAKQRWLKVIRVA 845
[Close]
BLAST of SMED30014278 vs. Planmine SMEST
Match: SMESG000061502.1 (SMESG000061502.1)

HSP 1 Score: 1313.13 bits (3397), Expect = 0.000e+0
Identity = 650/654 (99.39%), Postives = 652/654 (99.69%), Query Frame = 1 
Query:  292 MEKSRSRFSKWLTPNRVPIKALTRTKSVFTKASNTLPSNFDNCLEKKKCLSLDRMEIDTNADKMELENLPNEKSIYSSLQPEIYASLDSSSSDIDNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGSTCNECFDILTNQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVLNSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSSFNVVNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNIQSST 2253
            MEKSRSRFSKWLTPNRVPIKALTRTKSVFTKASNTLPSNFDNCLEKKKCLSLDRMEIDTNADKMELENLPNEKSIYSSLQPEIYASLDSSSSDIDNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFE RNQLLSSLYSQDFQFKVIADEAIVIYMKQNSE +ALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGSTCNECFDILTNQDRKADSIEKQIIKQKRIQRDGLFKGWLTISKISSLYIDAIEFQQRMFCVLNSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNS+FNVVNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNIQSST
Sbjct:    1 MEKSRSRFSKWLTPNRVPIKALTRTKSVFTKASNTLPSNFDNCLEKKKCLSLDRMEIDTNADKMELENLPNEKSIYSSLQPEIYASLDSSSSDIDNQSLHSTNSFSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSALNWYKIFYTSFEGRNQLLSSLYSQDFQFKVIADEAIVIYMKQNSEKHALNLPWILSSIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGSTCNECFDILTNQDRKADSIEKQIIKQKRIQRDGLFKGWLTISKISSLYIDAIEFQQRMFCVLNSDCTIYTYERQEDKYHQLPIRVLRATFNNDIKNSNFNVVNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNIQSST 654
[Close]
BLAST of SMED30014278 vs. Planmine SMEST
Match: SMESG000036666.1 (SMESG000036666.1)

HSP 1 Score: 116.316 bits (290), Expect = 1.072e-26
Identity = 135/578 (23.36%), Postives = 237/578 (41.00%), Query Frame = 1 
Query:  556 SSSSDIDNQSLHSTNS--FSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVIS----NDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSE-NYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLE-RSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSP-SIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGS-TCNECFDILTNQDRKA-----DSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL-NSDCTIYTYERQEDKYHQLPIRVLRAT--------FNNDIKNSSFNVVNITKNGVKYSIEADSQDEALKWIQSI 2217
            S +S IDN++  S     +   L NI  E +     + +    L    +    +F  N E S+ +  +F++++     H LY+  L  +          L  +F +  I   LN YK F+  +   ++ L      +      A + +   +K   +    L L   L ++  SLF F++ + RY+    +  E R +  D    I ++L   N   D  +F+ T +E NL++     +  + +FI+KG   K+ R+   M  R + LF+  ++               +L+L   + S I SE    + + G  + + +   +F  + E     WI KL   I +  +  N   + I+               IG   P WQ +  +NFCNG NC+ RF       +C  DGLLYC++C    A L +     S  C  C+ IL N+D+ +     ++ ++     ++  R G+   WL   +I +          + FC L N    +  Y++ EDK     I +LR T        F   +K   F + ++ KN   Y  +  S +   +W+Q +
Sbjct:   52 SENSSIDNKNTESDAECEYVSKLDNITNECVNFINNILKSLSYLMEFKAALHAEFHDNKEISSYLTSVFREIE---PLHMLYKLVLEKITELKDKGTFCLPDLFLDNEIKGPLNIYKSFFGQYSINSKWLGEFIKSN-----TACQEVCKQVKDRLQIGELLTLESCLYTVFGSLFSFDLFINRYASCFGEKDEARQKAEDVKTQISSLLSIINKNLDQENFLLTHKELNLMTGRSRETKIATKFIYKGNASKLSRRDQRMLPRQLMLFSDCLY---------------ELSLDTMQISKIISEDDKISLKWGLNIFTREALQDFYFEDEETMNLWISKLQLVIGEKAVVPNDVSKAISIL------------KIGEEPPRWQKDCNSNFCNGHNCNQRFSSTVRRHHCRTDGLLYCDSCCSLKAVLKFEKNCESRVCEPCYVIL-NRDKISPQEVKEAEKQLETVYEKKTRKGMKMDWLE-ERIYNCEKGVFNSSVKYFCELHNEHPFLALYDKLEDKNKHHGIMLLRMTVCIKKQSRFIRKLKPQQFTIEHMDKNEA-YLFDTPSPESCNEWVQCL 591
[Close]
BLAST of SMED30014278 vs. Planmine SMEST
Match: SMESG000036666.1 (SMESG000036666.1)

HSP 1 Score: 114.005 bits (284), Expect = 6.411e-26
Identity = 137/593 (23.10%), Postives = 240/593 (40.47%), Query Frame = 1 
Query:  556 SSSSDIDNQSLHSTNS-----------------FSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVIS----NDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSE-NYALNLPWILSSIKDSLFHFEILLARYSEHLDDNLE-RSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLLSTIDPLSP-SIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGS-TCNECFDILTNQDRKA-----DSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVL-NSDCTIYTYERQEDKYHQLPIRVLRAT--------FNNDIKNSSFNVVNITKNGVKYSIEADSQDEALKWIQSI 2217
            S +S IDN+S + T+S                 +   L NI  E +     + +    L    +    +F  N E S+ +  +F++++     H LY+  L  +          L  +F +  I   LN YK F+  +   ++ L      +      A + +   +K   +    L L   L ++  SLF F++ + RY+    +  E R +  D    I ++L   N   D  +F+ T +E NL++     +  + +FI+KG   K+ R+   M  R + LF+  ++               +L+L   + S I SE    + + G  + + +   +F  + E     WI KL   I +  +  N   + I+               IG   P WQ +  +NFCNG NC+ RF       +C  DGLLYC++C    A L +     S  C  C+ IL N+D+ +     ++ ++     ++  R G+   WL   +I +          + FC L N    +  Y++ EDK     I +LR T        F   +K   F + ++ KN   Y  +  S +   +W+Q +
Sbjct:   52 SENSSIDNKSENCTSSNPSLKGRSDTESDAECEYVSKLDNITNECVNFINNILKSLSYLMEFKAALHAEFHDNKEISSYLTSVFREIE---PLHMLYKLVLEKITELKDKGTFCLPDLFLDNEIKGPLNIYKSFFGQYSINSKWLGEFIKSN-----TACQEVCKQVKDRLQIGELLTLESCLYTVFGSLFSFDLFINRYASCFGEKDEARQKAEDVKTQISSLLSIINKNLDQENFLLTHKELNLMTGRSRETKIATKFIYKGNASKLSRRDQRMLPRQLMLFSDCLY---------------ELSLDTMQISKIISEDDKISLKWGLNIFTREALQDFYFEDEETMNLWISKLQLVIGEKAVVPNDVSKAISIL------------KIGEEPPRWQKDCNSNFCNGHNCNQRFSSTVRRHHCRTDGLLYCDSCCSLKAVLKFEKNCESRVCEPCYVIL-NRDKISPQEVKEAEKQLETVYEKKTRKGMKMDWLE-ERIYNCEKGVFNSSVKYFCELHNEHPFLALYDKLEDKNKHHGIMLLRMTVCIKKQSRFIRKLKPQQFTIEHMDKNEA-YLFDTPSPESCNEWVQCL 606
[Close]
BLAST of SMED30014278 vs. Planmine SMEST
Match: SMESG000014968.1 (SMESG000014968.1)

HSP 1 Score: 113.62 bits (283), Expect = 8.614e-26
Identity = 123/501 (24.55%), Postives = 221/501 (44.11%), Query Frame = 1 
Query:  625 IKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVIS-NDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDD-NLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLL--STIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHT----YKIKHQLNLSMCKFSIINSELKSPNSRK-GFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGS-TCNECFDILT-NQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVLN-SDCTIYTYERQEDKYHQLPIRVL 2091
            I +E +     +++    L+    +  ++FA +FE    I  +F+D+  + S ++L +  L  + + N+  L  +F +Q I S+LN+YK F + +   ++ +  L   + + +     +I        EN  L+L     S+ +SLF  E+++ R+S+   + + E ++  +   +++NIL S     D   FIKT  E NLL   ++ P   S RFI K  V+K   +      R++ LF+  +++   +I  H      +++ +L+L   + S I  E+        G  + + +    F  +      +W+E +   I                  N +  +    A +G +EP WQ +  T +CNG NC  +F  +    +C  DGL+YCE+C  Y   L +     S  C+ C+ ILT N D+ A   +       R  R G+   WL ++ + S      +     FC L+  D  +  Y   EDK     I +L
Sbjct:   76 IAQECVDFLYNISKCLSQLKKFKDELEKEFAEDFELKIQITGVFRDIVPLDSVYKLIEKSLGDIQNQNECLLPDLFLHQEIKSSLNFYKSFLSQYAVNSKWIVQLNKTNVKCQRACQRSI------QEEN--LSLESCHYSVFNSLFSLELIIERFSKCFQEQDPEYTKAREVKTILRNILLSVPQ--DQEIFIKTHHELNLLIGRSVVP-KVSTRFISKVTVKKYSSKDNTELTRLLVLFSDCLYV---AIPSHNNQGISRVRQELSLRYMRVSKIPDEVSIKGKEGCGLNINTLEMNKAFYFEDINMLKSWMELIKKAIGSV---------------NTLFSNSKPPAILGESEPVWQKDNATGYCNGFNCLSQFTFSNRRHHCRADGLIYCESCSSYRIKLKFGKSNTSRVCDLCYKILTENSDQVAQYKKDLNSVFDRKTRKGVKLSWLKVADMKS-----PKTYSEYFCELDKEDPFLKLYRNFEDKVRSFDIILL 542
[Close]
BLAST of SMED30014278 vs. Planmine SMEST
Match: SMESG000014968.1 (SMESG000014968.1)

HSP 1 Score: 113.235 bits (282), Expect = 9.484e-26
Identity = 122/498 (24.50%), Postives = 219/498 (43.98%), Query Frame = 1 
Query:  625 IKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNVIERIFKDLKCMSSFHQLYQAELNAVIS-NDLPLSMVFTNQVINSALNWYKIFYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILSSIKDSLFHFEILLARYSEHLDD-NLERSRINDAIKLIQNILHSCNMQCDYNDFIKTQQEYNLL--STIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTHMIFITGKSIQFHTY-KIKHQLNLSMCKFSIINSELKSPNSRK-GFRLESGDFCCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTVRADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCLGYSAFLSYSNQFGS-TCNECFDILT-NQDRKADSIEXXXXXXXXXXXDGLFKGWLTISKISSLYIDAIEFQQRMFCVLN-SDCTIYTYERQEDKYHQLPIRVL 2091
            I +E +     +++    L+    +  ++FA +FE    I  +F+D+  + S ++L +  L  + + N+  L  +F +Q I S+LN+YK F + +   ++ +  L   + + +     +I        EN  L+L     S+ +SLF  E+++ R+S+   + + E ++  +   +++NIL S     D   FIKT  E NLL   ++ P   S RFI K  V+K   +      R++ LF+  +++   S       +++ +L+L   + S I  E+        G  + + +    F  +      +W+E +   I                  N +  +    A +G +EP WQ +  T +CNG NC  +F  +    +C  DGL+YCE+C  Y   L +     S  C+ C+ ILT N D+ A   +       R  R G+   WL ++ + S      +     FC L+  D  +  Y   EDK     I +L
Sbjct:   74 IAQECVDFLYNISKCLSQLKKFKDELEKEFAEDFELKIQITGVFRDIVPLDSVYKLIEKSLGDIQNQNECLLPDLFLHQEIKSSLNFYKSFLSQYAVNSKWIVQLNKTNVKCQRACQRSI------QEEN--LSLESCHYSVFNSLFSLELIIERFSKCFQEQDPEYTKAREVKTILRNILLSVPQ--DQEIFIKTHHELNLLIGRSVVP-KVSTRFISKVTVKKYSSKDNTELTRLLVLFSDCLYVAIPSHNNQGISRVRQELSLRYMRVSKIPDEVSIKGKEGCGLNINTLEMNKAFYFEDINMLKSWMELIKKAIGSV---------------NTLFSNSKPPAILGESEPVWQKDNATGYCNGFNCLSQFTFSNRRHHCRADGLIYCESCSSYRIKLKFGKSNTSRVCDLCYKILTENSDQVAQYKKDLNSVFDRKTRKGVKLSWLKVADMKS-----PKTYSEYFCELDKEDPFLKLYRNFEDKVRSFDIILL 540
The following BLAST results are available for this feature:
BLAST of SMED30014278 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FGD43.635e-1120.32FYVE, RhoGEF and PH domain containing 4 [Source:HG... [more]
FGD46.316e-1120.49FYVE, RhoGEF and PH domain containing 4 [Source:HG... [more]
FGD41.179e-1020.49FYVE, RhoGEF and PH domain containing 4 [Source:HG... [more]
FGD41.637e-1020.49FYVE, RhoGEF and PH domain containing 4 [Source:HG... [more]
FGD41.708e-1020.49FYVE, RhoGEF and PH domain containing 4 [Source:HG... [more]
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BLAST of SMED30014278 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30014278 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30014278 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
fgd4b2.231e-920.40FYVE, RhoGEF and PH domain containing 4b [Source:Z... [more]
fgd4a4.750e-819.26FYVE, RhoGEF and PH domain containing 4a [Source:Z... [more]
fgd4a9.501e-819.09FYVE, RhoGEF and PH domain containing 4a [Source:Z... [more]
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BLAST of SMED30014278 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
FGD41.195e-1321.09FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
FGD44.423e-1120.80FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
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BLAST of SMED30014278 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Fgd42.117e-1020.42FYVE, RhoGEF and PH domain containing 4 [Source:MG... [more]
Fgd42.512e-1020.42FYVE, RhoGEF and PH domain containing 4 [Source:MG... [more]
Fgd42.512e-1020.42FYVE, RhoGEF and PH domain containing 4 [Source:MG... [more]
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BLAST of SMED30014278 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q96M96|FGD4_HUMAN3.033e-1020.49FYVE, RhoGEF and PH domain-containing protein 4 OS... [more]
sp|O88387|FGD4_RAT6.672e-1020.26FYVE, RhoGEF and PH domain-containing protein 4 OS... [more]
sp|Q91ZT5|FGD4_MOUSE1.757e-920.42FYVE, RhoGEF and PH domain-containing protein 4 OS... [more]
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BLAST of SMED30014278 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B8Y3762.001e-1622.06Uncharacterized protein OS=Xenopus tropicalis OX=8... [more]
A0A1L8GQD49.456e-1421.17Uncharacterized protein OS=Xenopus laevis OX=8355 ... [more]
W5N0M91.491e-1220.18FYVE, RhoGEF and PH domain containing 2 OS=Lepisos... [more]
A0A504YG183.907e-1222.57FYVE RhoGEF and PH domain-containing protein 2 (Fr... [more]
A0A4Z2DQC25.237e-1222.25FYVE, RhoGEF and PH domain-containing protein OS=S... [more]
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BLAST of SMED30014278 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000014177.21.063e-1222.34FYVE, RhoGEF and PH domain-containing protein 6-li... [more]
ENSAMXT00000032138.12.071e-719.11FYVE, RhoGEF and PH domain-containing protein 4-li... [more]
ENSAMXT00000054774.12.119e-719.11FYVE, RhoGEF and PH domain-containing protein 4-li... [more]
ENSAMXT00000055861.14.287e-718.23FYVE, RhoGEF and PH domain-containing protein 4-li... [more]
ENSAMXT00000030769.14.389e-719.11FYVE, RhoGEF and PH domain-containing protein 4-li... [more]
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BLAST of SMED30014278 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30014278 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30014278 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30014278 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fgd4a1.941e-1019.79FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
fgd4a3.995e-1019.79FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
fgd4a5.752e-1019.79FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
fgd4a5.997e-1019.79FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
fgd4a8.991e-1019.96FYVE, RhoGEF and PH domain containing 4 [Source:NC... [more]
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BLAST of SMED30014278 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000061502.10.000e+099.39SMESG000061502.1[more]
SMESG000036666.11.072e-2623.36SMESG000036666.1[more]
SMESG000036666.16.411e-2623.10SMESG000036666.1[more]
SMESG000014968.18.614e-2624.55SMESG000014968.1[more]
SMESG000014968.19.484e-2624.50SMESG000014968.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014278 ID=SMED30014278|Name=SMED30014278|organism=Schmidtea mediterranea sexual|type=transcript|length=2411bp
ACTGATAACTAAGTAAACAATTTGATCACTTAACAAAAATCAAAGATTTC
ACAAGGATTCGACGAGAAATTTCATTTCGAATATACATACAAATGTACAG
CACACTTCACAACACTGAGTTCTGATTGGTTGGTTTTAATCCAATAAAAT
TCCAAAATACACCTGTGACTATGACACGCTAGTTGATGTGAGTGCGCACA
CAAATTGAAAAAAATATGTACAAAATTTAAATGTACACTATATTGAGTTG
TTTATTGCGATTTAAATTTTTTTTTATTATTTCAAAATACTATGGAAAAA
AGCAGATCAAGATTTTCCAAATGGCTCACTCCGAATCGTGTTCCAATTAA
AGCTTTAACTCGAACGAAAAGTGTGTTTACTAAGGCATCGAATACTCTAC
CAAGCAATTTCGATAATTGTTTAGAGAAAAAAAAATGTCTGAGTTTAGAC
AGAATGGAAATAGATACAAATGCCGACAAAATGGAATTGGAAAATCTACC
AAATGAGAAATCGATTTATTCTTCTCTTCAACCAGAGATTTATGCCAGTC
TTGATTCATCCAGTTCAGATATAGACAACCAATCTCTACATTCTACAAAT
TCTTTTTCTCAAGATCTAGCCAACATCAAAAAGGAGCTTATTTTTCGAAC
TCAAACAGTGACAAGAGGATTTCAAATTTTAGAGATGATCTATTCAAAAG
CCACGGAAAAATTTGCTGGAAATTTCGAGAAATCCAATGTGATTGAAAGG
ATATTCAAAGATCTGAAATGTATGAGTAGTTTCCACCAACTTTACCAAGC
TGAACTGAACGCGGTTATCAGTAATGATTTACCCCTGTCTATGGTATTCA
CCAACCAAGTGATAAACAGTGCCCTGAATTGGTACAAGATATTTTATACA
TCATTTGAGGCTCGGAACCAACTACTGAGCTCATTGTATTCCCAAGATTT
CCAATTCAAAGTCATTGCTGATGAGGCTATAGTCATTTACATGAAACAGA
ATTCAGAAAACTATGCCCTAAATCTACCGTGGATTCTTAGCTCAATAAAA
GACAGTCTATTTCATTTTGAAATATTATTAGCAAGGTATTCTGAGCACCT
CGACGACAACTTGGAAAGATCTCGAATAAATGATGCTATCAAATTGATTC
AAAATATTTTACACAGTTGTAATATGCAATGCGATTACAACGACTTCATC
AAAACGCAACAAGAATACAATCTTCTATCAACGATAGATCCGTTAAGTCC
AAGCATTAGATTTATTCATAAAGGTCTTGTTCAGAAGGTCTGTCGTCAAA
GCTTTTGCATGAGACAAAGAATGATATTCTTATTTACCCACATGATATTC
ATCACGGGAAAAAGTATTCAATTCCACACTTACAAAATCAAACACCAATT
GAACCTGTCTATGTGTAAATTCTCAATCATCAACTCCGAGCTGAAGTCAC
CAAATTCCAGAAAAGGATTCCGATTGGAAAGTGGAGACTTTTGCTGTGAA
TTTCTATTGGATAAAGAAACTGAATTTTATACTTGGATTGAAAAATTGAA
TTCTACCATTTGTCAAGCAAAGTTGAGAAAAAATTCATTCGACCGTAAAA
TTACTAAATATTTCAACAGAATTAACGATAGTGATACCGTAAGAGCCGAC
ATAGGAGTAACAGAACCATATTGGCAGTTGGAAGAAAAAACAAACTTTTG
CAATGGTCTTAACTGTTCATTTAGATTCGATCCCAACAAACCACCAAGGA
ATTGTTCGGGAGATGGCTTGTTGTACTGTGAGAATTGTCTTGGATATTCT
GCGTTTCTCTCTTACTCTAATCAATTTGGATCTACGTGCAATGAATGCTT
TGATATTCTAACAAATCAAGACCGTAAAGCTGACTCAATAGAAAAGCAAA
TAATTAAACAGAAAAGAATCCAGCGTGACGGTTTATTTAAAGGCTGGCTG
ACGATTAGCAAGATCTCCTCTTTGTATATAGATGCTATAGAATTTCAGCA
AAGAATGTTTTGTGTTTTGAACTCTGATTGCACAATTTATACCTATGAAC
GTCAGGAAGATAAATATCATCAGTTACCAATACGAGTCTTGCGCGCAACT
TTCAACAATGACATCAAAAACTCAAGTTTCAATGTTGTAAATATAACGAA
AAATGGAGTAAAGTATTCAATTGAAGCCGATTCGCAAGACGAAGCGTTGA
AATGGATACAATCGATCAAACTGTGCCAACTTGATAATATTCAATCTTCA
ACATAAATTTTTCTTTTCACTCAATTCCCAATTTGTAAAGCCTTCCAATT
TTCCATTCATTTACGAATAAAAACAATTTATTTCAACATGATTTACAGCA
GCATTTGGATCTTAACATGAGATTTATACTTTACACATTTTGTGATTATA
TTGACTATATA
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protein sequence of SMED30014278-orf-1

>SMED30014278-orf-1 ID=SMED30014278-orf-1|Name=SMED30014278-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=655bp
MEKSRSRFSKWLTPNRVPIKALTRTKSVFTKASNTLPSNFDNCLEKKKCL
SLDRMEIDTNADKMELENLPNEKSIYSSLQPEIYASLDSSSSDIDNQSLH
STNSFSQDLANIKKELIFRTQTVTRGFQILEMIYSKATEKFAGNFEKSNV
IERIFKDLKCMSSFHQLYQAELNAVISNDLPLSMVFTNQVINSALNWYKI
FYTSFEARNQLLSSLYSQDFQFKVIADEAIVIYMKQNSENYALNLPWILS
SIKDSLFHFEILLARYSEHLDDNLERSRINDAIKLIQNILHSCNMQCDYN
DFIKTQQEYNLLSTIDPLSPSIRFIHKGLVQKVCRQSFCMRQRMIFLFTH
MIFITGKSIQFHTYKIKHQLNLSMCKFSIINSELKSPNSRKGFRLESGDF
CCEFLLDKETEFYTWIEKLNSTICQAKLRKNSFDRKITKYFNRINDSDTV
RADIGVTEPYWQLEEKTNFCNGLNCSFRFDPNKPPRNCSGDGLLYCENCL
GYSAFLSYSNQFGSTCNECFDILTNQDRKADSIEKQIIKQKRIQRDGLFK
GWLTISKISSLYIDAIEFQQRMFCVLNSDCTIYTYERQEDKYHQLPIRVL
RATFNNDIKNSSFNVVNITKNGVKYSIEADSQDEALKWIQSIKLCQLDNI
QSST*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR035899DBL_dom_sf
IPR000306Znf_FYVE
IPR001849PH_domain
IPR013083Znf_RING/FYVE/PHD
IPR011993PH-like_dom_sf
IPR000219DH-domain
IPR011011Znf_FYVE_PHD
Vocabulary: molecular function
TermDefinition
GO:0005085guanyl-nucleotide exchange factor activity
GO:0046872metal ion binding
GO:0005089Rho guanyl-nucleotide exchange factor activity
Vocabulary: biological process
TermDefinition
GO:0035023regulation of Rho protein signal transduction
GO:0043547positive regulation of GTPase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000306FYVE zinc fingerSMARTSM00064fyve_4coord: 456..525
e-value: 0.0093
score: 10.4
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 324..426
e-value: 0.14
score: 21.2
coord: 547..649
e-value: 0.0046
score: 26.2
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 546..647
score: 7.649
IPR035899Dbl homology (DH) domain superfamilyGENE3DG3DSA:1.20.900.10coord: 107..306
e-value: 4.7E-5
score: 25.3
IPR035899Dbl homology (DH) domain superfamilySUPERFAMILYSSF48065DBL homology domain (DH-domain)coord: 88..294
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 452..537
e-value: 7.6E-6
score: 27.5
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 544..650
e-value: 8.0E-7
score: 31.2
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 307..451
e-value: 4.7E-15
score: 57.6
NoneNo IPR availablePANTHERPTHR12673:SF82FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2coord: 48..643
NoneNo IPR availablePANTHERPTHR12673FACIOGENITAL DYSPLASIA PROTEINcoord: 48..643
NoneNo IPR availableCDDcd00821PHcoord: 570..642
e-value: 0.00624686
score: 34.4406
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 322..425
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 547..650
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 108..296
score: 8.963
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILYSSF57903FYVE/PHD zinc fingercoord: 459..531