WH1 domain-containing protein

Overview
NameWH1 domain-containing protein
Smed IDSMED30014250
Length (bp)1123
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of WH1 domain-containing protein (SMED30014250) t-SNE clustered cells

Violin plots show distribution of expression levels for WH1 domain-containing protein (SMED30014250) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WH1 domain-containing protein (SMED30014250) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WH1 domain-containing protein (SMED30014250) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014250

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30014250h1SMcG0015438 SmedASXL_010188SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30014250h1SMcG0015438 dd_Smed_v4_22545_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30014250h1SMcG0015438 dd_Smed_v6_22545_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Human
Match: ENAH (ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:18271])

HSP 1 Score: 79.337 bits (194), Expect = 1.499e-16
Identity = 45/139 (32.37%), Postives = 73/139 (52.52%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPEL 513
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++ +   ++T+     + +  C P L
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQETAQSKVTATQDSTNLRCI-FCGPTL 139
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Human
Match: ENAH (ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:18271])

HSP 1 Score: 77.0258 bits (188), Expect = 9.349e-15
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLE 522
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++          LP +  V+  P +  LE
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQ--VQNGPSQEELE 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Human
Match: ENAH (ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:18271])

HSP 1 Score: 76.6406 bits (187), Expect = 1.238e-14
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLE 522
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++          LP +  V+  P +  LE
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQ--VQNGPSQEELE 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Human
Match: ENAH (ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:18271])

HSP 1 Score: 76.6406 bits (187), Expect = 1.891e-14
Identity = 49/152 (32.24%), Postives = 78/152 (51.32%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSHSNCEI 552
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++    +    +LPR +N ++      ++ G S    EI
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQETV---FYLGPTLPR-QNSQL---PAQVQNGPSQEELEI 146
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Human
Match: EVL (Enah/Vasp-like [Source:HGNC Symbol;Acc:HGNC:20234])

HSP 1 Score: 70.4774 bits (171), Expect = 2.203e-14
Identity = 40/116 (34.48%), Postives = 64/116 (55.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNI-NTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            EQSI     +++ Y   + +W  +     G S + +Y +   NT+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  +NS + 
Sbjct:    5 EQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNIMNSQEG 119
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Celegans
Match: unc-34 (UNC-34 [Source:UniProtKB/TrEMBL;Acc:G5EG53])

HSP 1 Score: 48.9062 bits (115), Expect = 4.327e-6
Identity = 36/124 (29.03%), Postives = 60/124 (48.39%), Query Frame = 1 
Query:   67 LSSFLCKFSAMEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHKILNDEI----VLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSL 426
            +SS  C  +AM +        ++ Y +    W  LG    + S+T  R  I   R    +I+++      +LN  ++  + Y++ +P FHQW      VYGLNF +  +A  F SIV  A+++L
Sbjct:    1 MSSEACIATAMAR--------VMTYNESTKGWVLLGG--NDDSMTNVRL-IQDIRRPEFRIVSNRADSTNILNCNIYRGIKYHKATPMFHQWRTEQRRVYGLNFENEQDATMFLSIVLQAIETL 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Celegans
Match: unc-34 (UNC-34 [Source:UniProtKB/TrEMBL;Acc:G5EG53])

HSP 1 Score: 47.3654 bits (111), Expect = 7.912e-6
Identity = 31/105 (29.52%), Postives = 53/105 (50.48%), Query Frame = 1 
Query:  265 VLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMN-YSSTKSLPRKKNVKICPPE----LHLEKGYSHSNCEISNFK 564
            +LN  ++  + Y++ +P FHQW      VYGLNF +  +A  F SIV   LQ++ + +  +MN  S  + + +  NV   P +    +H    +   N   +NF+
Sbjct:   46 ILNCNIYRGIKYHKATPMFHQWRTEQRRVYGLNFENEQDATMFLSIV---LQAIETLKVHDMNGISDYQQMHQVDNVYQDPHQHLMHIHSAPNFHDENQNAANFR 147
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Fly
Match: ena (gene:FBgn0000578 transcript:FBtr0340450)

HSP 1 Score: 78.9518 bits (193), Expect = 1.243e-15
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:    3 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Fly
Match: ena (gene:FBgn0000578 transcript:FBtr0114623)

HSP 1 Score: 78.9518 bits (193), Expect = 1.367e-15
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:  299 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 409
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Fly
Match: ena (gene:FBgn0000578 transcript:FBtr0086584)

HSP 1 Score: 78.9518 bits (193), Expect = 1.459e-15
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:  148 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 258
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Fly
Match: ena (gene:FBgn0000578 transcript:FBtr0086582)

HSP 1 Score: 78.9518 bits (193), Expect = 1.475e-15
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:    3 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Fly
Match: ena (gene:FBgn0000578 transcript:FBtr0100176)

HSP 1 Score: 78.9518 bits (193), Expect = 1.475e-15
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:    3 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Match: enah (ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010323-11])

HSP 1 Score: 73.9442 bits (180), Expect = 1.410e-15
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Match: enah (ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010323-11])

HSP 1 Score: 75.485 bits (184), Expect = 1.763e-14
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Match: enah (ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010323-11])

HSP 1 Score: 75.0998 bits (183), Expect = 3.048e-14
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:   31 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Match: evla (Enah/Vasp-like a [Source:ZFIN;Acc:ZDB-GENE-000607-65])

HSP 1 Score: 71.2478 bits (173), Expect = 5.565e-14
Identity = 39/113 (34.51%), Postives = 63/113 (55.75%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI     +++ Y   + +W  +     G S + +Y + +N ++R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  L S
Sbjct:    3 EQSICQARASVMIYDDTSKKWVPVKPGQQGFSRINIYHNTVNNSFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSTAMLFALNVLGS 114
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Match: evla (Enah/Vasp-like a [Source:ZFIN;Acc:ZDB-GENE-000607-65])

HSP 1 Score: 72.7886 bits (177), Expect = 9.885e-14
Identity = 39/113 (34.51%), Postives = 63/113 (55.75%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI     +++ Y   + +W  +     G S + +Y + +N ++R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  L S
Sbjct:    6 EQSICQARASVMIYDDTSKKWVPVKPGQQGFSRINIYHNTVNNSFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSTAMLFALNVLGS 117
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Match: sorbs2 (sorbin and SH3 domain containing 2 [Source:Xenbase;Acc:XB-GENE-478190])

HSP 1 Score: 78.5666 bits (192), Expect = 2.827e-15
Identity = 42/116 (36.21%), Postives = 63/116 (54.31%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQST 444
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +S 
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQESV 117
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Match: sorbs2 (sorbin and SH3 domain containing 2 [Source:Xenbase;Acc:XB-GENE-478190])

HSP 1 Score: 78.5666 bits (192), Expect = 3.634e-15
Identity = 42/116 (36.21%), Postives = 64/116 (55.17%), Query Frame = 1 
Query:   97 MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            +EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +S
Sbjct:    1 IEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQES 115
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Match: sorbs2 (sorbin and SH3 domain containing 2 [Source:Xenbase;Acc:XB-GENE-478190])

HSP 1 Score: 77.0258 bits (188), Expect = 5.662e-15
Identity = 42/116 (36.21%), Postives = 64/116 (55.17%), Query Frame = 1 
Query:   97 MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            +EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +S
Sbjct:    1 IEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQES 115
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Match: sorbs2 (sorbin and SH3 domain containing 2 [Source:Xenbase;Acc:XB-GENE-478190])

HSP 1 Score: 77.7962 bits (190), Expect = 6.212e-15
Identity = 42/115 (36.52%), Postives = 63/115 (54.78%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +S
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQES 116
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Match: sorbs2 (sorbin and SH3 domain containing 2 [Source:Xenbase;Acc:XB-GENE-478190])

HSP 1 Score: 77.7962 bits (190), Expect = 6.693e-15
Identity = 42/115 (36.52%), Postives = 63/115 (54.78%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +S
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQES 116
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Match: Enah (ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360])

HSP 1 Score: 79.7221 bits (195), Expect = 1.112e-15
Identity = 42/124 (33.87%), Postives = 68/124 (54.84%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTK 468
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++ +   ++T+
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQ 125
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Match: Enah (ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360])

HSP 1 Score: 77.411 bits (189), Expect = 5.203e-15
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLE 522
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++          LP +  V+  P +  LE
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAGPTLPRQNSQLPAQ--VQNGPSQEELE 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Match: Enah (ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360])

HSP 1 Score: 77.0258 bits (188), Expect = 5.769e-15
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLE 522
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++          LP +  V+  P +  LE
Sbjct:   23 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAGPTLPRQNSQLPAQ--VQNGPSQEELE 161
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Match: Enah (ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360])

HSP 1 Score: 77.0258 bits (188), Expect = 5.795e-15
Identity = 44/129 (34.11%), Postives = 68/129 (52.71%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRK 483
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +       +  +LPR+
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQE-------AGPTLPRQ 123
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Match: Enah (ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360])

HSP 1 Score: 77.0258 bits (188), Expect = 6.498e-15
Identity = 44/129 (34.11%), Postives = 68/129 (52.71%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRK 483
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS +       +  +LPR+
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQE-------AGPTLPRQ 123
[Close]
BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03173|ENAH_MOUSE (Protein enabled homolog OS=Mus musculus OX=10090 GN=Enah PE=1 SV=2)

HSP 1 Score: 79.7221 bits (195), Expect = 8.204e-15
Identity = 42/124 (33.87%), Postives = 68/124 (54.84%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTK 468
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++ +   ++T+
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQ 125
[Close]
BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8T4F7|ENA_DROME (Protein enabled OS=Drosophila melanogaster OX=7227 GN=ena PE=1 SV=4)

HSP 1 Score: 78.9518 bits (193), Expect = 1.371e-14
Identity = 40/112 (35.71%), Postives = 64/112 (57.14%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSII    +++ Y     +W   GS +G S + +Y    N T+R V  K+ + E+V+N  +   + YN+ + TFHQW D+ F VYGLNF   ++A+ F+  +  AL+ L+ 
Sbjct:  299 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKF-VYGLNFSSQNDAENFARAMMHALEVLSG 409
[Close]
BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8N8S7|ENAH_HUMAN (Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2)

HSP 1 Score: 77.0258 bits (188), Expect = 4.490e-14
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLE 522
            EQSI      ++ Y   N +W   G   G S + +Y  +  NT+R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS ++          LP +  V+  P +  LE
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQ--VQNGPSQEELE 141
[Close]
BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Match: sp|O08719|EVL_RAT (Ena/VASP-like protein OS=Rattus norvegicus OX=10116 GN=Evl PE=1 SV=2)

HSP 1 Score: 73.559 bits (179), Expect = 4.613e-13
Identity = 42/135 (31.11%), Postives = 70/135 (51.85%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNI-NTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKI 498
            EQSI     +++ Y   + +W  +     G S + +Y +   NT+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  +NS +         ++ P  + + I
Sbjct:    9 EQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSTQRQVQNGPSPEEMDI 142
[Close]
BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9UI08|EVL_HUMAN (Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2)

HSP 1 Score: 73.1738 bits (178), Expect = 5.607e-13
Identity = 40/113 (35.40%), Postives = 63/113 (55.75%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNI-NTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI     +++ Y   + +W  +     G S + +Y +   NT+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  +NS
Sbjct:    3 EQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNIMNS 114
[Close]
BLAST of WH1 domain-containing protein vs. TrEMBL
Match: A0A1S3HT73 (protein enabled homolog OS=Lingula unguis OX=7574 GN=LOC106157956 PE=4 SV=1)

HSP 1 Score: 88.1965 bits (217), Expect = 5.728e-17
Identity = 47/144 (32.64%), Postives = 78/144 (54.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKG 528
            E SI+    +++ Y   N +W   G   G S + +Y   IN T+R V  K+ + E+V+N  +   + YN+ +PTFHQW DN   VYGLNF    +A+ F+  +  AL+++NS Q ++  Y + ++L         PP  +++ G
Sbjct:   34 EHSIVAARASVMIYDDANKKWVPSGMSQGISKVHIYHHPINNTFRVVGRKMQDHEVVINCAILKGLKYNQATPTFHQWRDNR-QVYGLNFASKEDAENFAHAMLTALETMNSIQRSQ--YQAPQALQTPPTAYQQPPSQYIQNG 174
[Close]
BLAST of WH1 domain-containing protein vs. TrEMBL
Match: A0A1S3J2Q9 (protein enabled homolog isoform X3 OS=Lingula unguis OX=7574 GN=LOC106169606 PE=4 SV=1)

HSP 1 Score: 90.1225 bits (222), Expect = 4.797e-16
Identity = 48/150 (32.00%), Postives = 80/150 (53.33%), Query Frame = 1 
Query:   82 CKFSAMEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKG 528
            C+    E SI+    +++ Y   N +W   G   G S + +Y   IN T+R V  K+ + E+V+N  +   + YN+ +PTFHQW DN   VYGLNF    +A+ F+  +  AL+++NS Q ++  Y + ++L         PP  +++ G
Sbjct:   15 CQCMCSEHSIVAARASVMIYDDANKKWVPSGMSQGISKVHIYHHPINNTFRVVGRKMQDHEVVINCAILKGLKYNQATPTFHQWRDNR-QVYGLNFASKEDAENFAHAMLTALETMNSIQRSQ--YQAPQALQTPPTAYQQPPSQYIQNG 161
[Close]
BLAST of WH1 domain-containing protein vs. TrEMBL
Match: A0A1S3J3X4 (protein enabled homolog isoform X1 OS=Lingula unguis OX=7574 GN=LOC106169606 PE=4 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.007e-15
Identity = 47/152 (30.92%), Postives = 82/152 (53.95%), Query Frame = 1 
Query:   76 FLCKFSAMEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKG 528
            ++ + +  E SI+    +++ Y   N +W   G   G S + +Y   IN T+R V  K+ + E+V+N  +   + YN+ +PTFHQW DN   VYGLNF    +A+ F+  +  AL+++NS Q ++  Y + ++L         PP  +++ G
Sbjct:   27 WVSELTLCEHSIVAARASVMIYDDANKKWVPSGMSQGISKVHIYHHPINNTFRVVGRKMQDHEVVINCAILKGLKYNQATPTFHQWRDNR-QVYGLNFASKEDAENFAHAMLTALETMNSIQRSQ--YQAPQALQTPPTAYQQPPSQYIQNG 175
[Close]
BLAST of WH1 domain-containing protein vs. TrEMBL
Match: A0A1S3J3Y3 (protein enabled homolog isoform X6 OS=Lingula unguis OX=7574 GN=LOC106169606 PE=4 SV=1)

HSP 1 Score: 88.5817 bits (218), Expect = 1.581e-15
Identity = 47/144 (32.64%), Postives = 78/144 (54.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKG 528
            E SI+    +++ Y   N +W   G   G S + +Y   IN T+R V  K+ + E+V+N  +   + YN+ +PTFHQW DN   VYGLNF    +A+ F+  +  AL+++NS Q ++  Y + ++L         PP  +++ G
Sbjct:    6 EHSIVAARASVMIYDDANKKWVPSGMSQGISKVHIYHHPINNTFRVVGRKMQDHEVVINCAILKGLKYNQATPTFHQWRDNR-QVYGLNFASKEDAENFAHAMLTALETMNSIQRSQ--YQAPQALQTPPTAYQQPPSQYIQNG 146
[Close]
BLAST of WH1 domain-containing protein vs. TrEMBL
Match: A0A1S3J2E2 (protein enabled homolog isoform X7 OS=Lingula unguis OX=7574 GN=LOC106169606 PE=4 SV=1)

HSP 1 Score: 88.5817 bits (218), Expect = 1.611e-15
Identity = 47/144 (32.64%), Postives = 78/144 (54.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKG 528
            E SI+    +++ Y   N +W   G   G S + +Y   IN T+R V  K+ + E+V+N  +   + YN+ +PTFHQW DN   VYGLNF    +A+ F+  +  AL+++NS Q ++  Y + ++L         PP  +++ G
Sbjct:    4 EHSIVAARASVMIYDDANKKWVPSGMSQGISKVHIYHHPINNTFRVVGRKMQDHEVVINCAILKGLKYNQATPTFHQWRDNR-QVYGLNFASKEDAENFAHAMLTALETMNSIQRSQ--YQAPQALQTPPTAYQQPPSQYIQNG 144
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Match: enah (ENAH actin regulator [Source:NCBI gene;Acc:103032123])

HSP 1 Score: 77.0258 bits (188), Expect = 5.171e-15
Identity = 47/147 (31.97%), Postives = 75/147 (51.02%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKI----CPPELHLEK 525
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS         +  +LPR +N ++     P EL +++
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS-------QDAGPTLPR-QNPQVQNGPSPEELEMQR 140
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Match: enah (ENAH actin regulator [Source:NCBI gene;Acc:103032123])

HSP 1 Score: 76.2554 bits (186), Expect = 1.359e-14
Identity = 40/113 (35.40%), Postives = 61/113 (53.98%), Query Frame = 1 
Query:   97 MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            +EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:    5 VEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 116
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Match: enah (ENAH actin regulator [Source:NCBI gene;Acc:103032123])

HSP 1 Score: 75.8702 bits (185), Expect = 1.756e-14
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:   31 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Match: enah (ENAH actin regulator [Source:NCBI gene;Acc:103032123])

HSP 1 Score: 75.8702 bits (185), Expect = 1.769e-14
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:   31 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 141
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Match: enah (ENAH actin regulator [Source:NCBI gene;Acc:103032123])

HSP 1 Score: 75.485 bits (184), Expect = 1.928e-14
Identity = 40/112 (35.71%), Postives = 60/112 (53.57%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            EQSI      ++ Y   N +W   G   G S + +Y  +  N +R V  KI + ++V+N  +   + YN+ + TFHQW D +  VYGLNF    +A  F+S +  AL+ LNS
Sbjct:    3 EQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRD-ARQVYGLNFGSKEDANVFASAMMHALEVLNS 113
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006730.1 (pep scaffold:Pmarinus_7.0:GL476423:313891:330988:1 gene:ENSPMAG00000006060.1 transcript:ENSPMAT00000006730.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 76.6406 bits (187), Expect = 1.389e-15
Identity = 41/117 (35.04%), Postives = 66/117 (56.41%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYR-SNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTE 447
            EQSI      ++ Y   N +W   G   G S + +Y  +++NT+R V  ++ + ++V+N  L   + YN+ +P FHQW D +  VYGLNF    +A  F++ +  AL +L SAQ T+
Sbjct:    3 EQSICQARAQVMVYDDANKKWLPSGGQQGFSRVHIYHHTSLNTFRVVGRRMQDQQVVINCSLSKGLKYNQATPMFHQWRD-ARQVYGLNFGSKEDANVFANGIMHALDAL-SAQDTK 117
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Nematostella
Match: EDO41208 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4T4])

HSP 1 Score: 76.2554 bits (186), Expect = 4.474e-17
Identity = 41/113 (36.28%), Postives = 58/113 (51.33%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSA 435
            E SI     +++ Y     QW   G   G S + +Y   +N T+R V  K+ +  +V+N  L   + YNE +PTFHQW D    VYGLNF    EA  F   V  AL++L ++
Sbjct:    3 EHSIAQARASVMLYNNEAKQWAPSGGSQGISRVHVYHHPVNNTFRIVGRKMADHAVVINCALAKGLKYNEATPTFHQWRDQR-QVYGLNFQSKDEADLFGQAVRDALETLKTS 114
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000036646.1 (vasodilator-stimulated phosphoprotein [Source:NCBI gene;Acc:101156997])

HSP 1 Score: 75.0998 bits (183), Expect = 1.307e-14
Identity = 43/118 (36.44%), Postives = 66/118 (55.93%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGS-VNGESSLTLYRS-NINTYRFVAHKILNDE-IVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQST 444
            E SI     T++ Y   N +W  +GS V   S + +Y +    T+R V  K+  D+ +V+N  +   M YN+ +PTFHQW D    V+GLNF    EA +F+S +  AL++LN++ S 
Sbjct:    3 ESSICQVKATVMMYDDGNKRWVPVGSDVPHFSRVQIYNNPTTRTFRVVGRKLQPDQQVVINCPIVKGMKYNQATPTFHQWRDPK-QVWGLNFGSKEEASQFASSIMHALETLNASPSA 119
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Match: evlb (ena/VASP-like protein [Source:NCBI gene;Acc:101159062])

HSP 1 Score: 75.0998 bits (183), Expect = 1.646e-14
Identity = 41/120 (34.17%), Postives = 66/120 (55.00%), Query Frame = 1 
Query:   79 LCKFSAMEQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNI-NTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            L +F   EQSI     +++ Y   + +W  +     G S + +Y +   NT+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  L++
Sbjct:   26 LAEFKVSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNVLSA 144
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000006482.2 (vasodilator-stimulated phosphoprotein [Source:NCBI gene;Acc:101156997])

HSP 1 Score: 75.0998 bits (183), Expect = 1.714e-14
Identity = 43/118 (36.44%), Postives = 66/118 (55.93%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGS-VNGESSLTLYRS-NINTYRFVAHKILNDE-IVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQST 444
            E SI     T++ Y   N +W  +GS V   S + +Y +    T+R V  K+  D+ +V+N  +   M YN+ +PTFHQW D    V+GLNF    EA +F+S +  AL++LN++ S 
Sbjct:    3 ESSICQVKATVMMYDDGNKRWVPVGSDVPHFSRVQIYNNPTTRTFRVVGRKLQPDQQVVINCPIVKGMKYNQATPTFHQWRDPK-QVWGLNFGSKEEASQFASSIMHALETLNASPSA 119
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Match: evla (ena/VASP-like protein [Source:NCBI gene;Acc:101173592])

HSP 1 Score: 73.1738 bits (178), Expect = 6.925e-14
Identity = 41/116 (35.34%), Postives = 64/116 (55.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            EQSI     +++ Y   + +W  +     G S + +Y +  N T+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  L+S  S
Sbjct:    3 EQSICQARASVMVYDDASKKWVPIKPGQQGFSRINIYHNTANNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNVLSSPDS 117
[Close]
BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Match: evla (ena/VASP-like protein [Source:NCBI gene;Acc:101173592])

HSP 1 Score: 72.4034 bits (176), Expect = 1.274e-13
Identity = 41/116 (35.34%), Postives = 64/116 (55.17%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELG-SVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQS 441
            EQSI     +++ Y   + +W  +     G S + +Y +  N T+R V  K+ + ++V+N  +   + YN+ +PTFHQW D +  VYGLNF    EA  FS+ + FAL  L+S  S
Sbjct:    3 EQSICQARASVMVYDDASKKWVPIKPGQQGFSRINIYHNTANNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRD-ARQVYGLNFASKEEATTFSNAMLFALNVLSSPDS 117
[Close]
BLAST of WH1 domain-containing protein vs. Planmine SMEST
Match: SMESG000052344.1 (SMESG000052344.1)

HSP 1 Score: 640.958 bits (1652), Expect = 0.000e+0
Identity = 312/326 (95.71%), Postives = 318/326 (97.55%), Query Frame = 1 
Query:   88 FSAMEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSHSNCEISNFKDNFSWQLSFDSKPHLKAKSKSFCIEPREVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNKCYYYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR 1065
            F  + QSIINTNVTILEYCKYNF+WKELGSVNGE SLTLYRSN+NTYRFVAHKILN+EIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNF DSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYS+SNCEISNFKDN SWQLSFDSKPHLKAKSKSFCIEP EVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNK +YYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR
Sbjct:    7 FLFLRQSIINTNVTILEYCKYNFEWKELGSVNGECSLTLYRSNMNTYRFVAHKILNNEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFTDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSYSNCEISNFKDNLSWQLSFDSKPHLKAKSKSFCIEPHEVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNKYHYYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR 332
[Close]
BLAST of WH1 domain-containing protein vs. Planmine SMEST
Match: SMESG000052344.1 (SMESG000052344.1)

HSP 1 Score: 639.802 bits (1649), Expect = 0.000e+0
Identity = 312/326 (95.71%), Postives = 318/326 (97.55%), Query Frame = 1 
Query:   88 FSAMEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSHSNCEISNFKDNFSWQLSFDSKPHLKAKSKSFCIEPREVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNKCYYYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR 1065
            F  + QSIINTNVTILEYCKYNF+WKELGSVNGE SLTLYRSN+NTYRFVAHKILN+EIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNF DSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYS+SNCEISNFKDN SWQLSFDSKPHLKAKSKSFCIEP EVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNK +YYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR
Sbjct:   15 FLFLRQSIINTNVTILEYCKYNFEWKELGSVNGECSLTLYRSNMNTYRFVAHKILNNEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFTDSSEAKRFSSIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSYSNCEISNFKDNLSWQLSFDSKPHLKAKSKSFCIEPHEVILNTSSALQVKKNLKGREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNNNNKYHYYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLTTDVIHNLESMKKEIISSIVYNMR 340
[Close]
BLAST of WH1 domain-containing protein vs. Planmine SMEST
Match: SMESG000052345.1 (SMESG000052345.1)

HSP 1 Score: 127.102 bits (318), Expect = 4.840e-33
Identity = 59/112 (52.68%), Postives = 78/112 (69.64%), Query Frame = 1 
Query:   97 MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            MEQ I+   V +L+Y     QW+ELGS  G   +++++S  N YRFV+ K  + E+VLN+FLFP+M+YNET+PTFHQW D S S YGLNF D +EAK+F   V  AL+ LNS
Sbjct:    1 MEQPIVQATVIVLKYSLSTGQWEELGSQKGTCVISIFKSPSNEYRFVSWKESSQEVVLNSFLFPTMNYNETTPTFHQWYDESKSAYGLNFTDPNEAKKFGIAVVSALEILNS 112
[Close]
BLAST of WH1 domain-containing protein vs. Planmine SMEST
Match: SMESG000052345.1 (SMESG000052345.1)

HSP 1 Score: 127.102 bits (318), Expect = 5.782e-33
Identity = 59/112 (52.68%), Postives = 78/112 (69.64%), Query Frame = 1 
Query:   97 MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLNS 432
            MEQ I+   V +L+Y     QW+ELGS  G   +++++S  N YRFV+ K  + E+VLN+FLFP+M+YNET+PTFHQW D S S YGLNF D +EAK+F   V  AL+ LNS
Sbjct:    1 MEQPIVQATVIVLKYSLSTGQWEELGSQKGTCVISIFKSPSNEYRFVSWKESSQEVVLNSFLFPTMNYNETTPTFHQWYDESKSAYGLNFTDPNEAKKFGIAVVSALEILNS 112
[Close]
BLAST of WH1 domain-containing protein vs. Planmine SMEST
Match: SMESG000063850.1 (SMESG000063850.1)

HSP 1 Score: 87.8113 bits (216), Expect = 9.535e-19
Identity = 41/111 (36.94%), Postives = 64/111 (57.66%), Query Frame = 1 
Query:  100 EQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNIN-TYRFVAHKILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFSSIVGFALQSLN 429
            E+ +     +++ +      W   GS  G S + L+R  +N TYR V  K+ + E+VLN  +F  + YN+  PTFHQW D    VYGLNF +  EA++F++ +  AL++LN
Sbjct:    3 EKPVATARASVMLFDAVTNSWVASGSTQGISKVQLFRHQLNNTYRVVGWKLNDKEVVLNCAIFRGLKYNQARPTFHQWRDTKHQVYGLNFTNKEEAEQFAAAILEALENLN 113
The following BLAST results are available for this feature:
BLAST of WH1 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENAH1.499e-1632.37ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:... [more]
ENAH9.349e-1533.10ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:... [more]
ENAH1.238e-1433.10ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:... [more]
ENAH1.891e-1432.24ENAH actin regulator [Source:HGNC Symbol;Acc:HGNC:... [more]
EVL2.203e-1434.48Enah/Vasp-like [Source:HGNC Symbol;Acc:HGNC:20234][more]
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BLAST of WH1 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
unc-344.327e-629.03UNC-34 [Source:UniProtKB/TrEMBL;Acc:G5EG53][more]
unc-347.912e-629.52UNC-34 [Source:UniProtKB/TrEMBL;Acc:G5EG53][more]
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BLAST of WH1 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ena1.243e-1535.71gene:FBgn0000578 transcript:FBtr0340450[more]
ena1.367e-1535.71gene:FBgn0000578 transcript:FBtr0114623[more]
ena1.459e-1535.71gene:FBgn0000578 transcript:FBtr0086584[more]
ena1.475e-1535.71gene:FBgn0000578 transcript:FBtr0086582[more]
ena1.475e-1535.71gene:FBgn0000578 transcript:FBtr0100176[more]
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BLAST of WH1 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
enah1.410e-1535.71ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010... [more]
enah1.763e-1435.71ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010... [more]
enah3.048e-1435.71ENAH actin regulator [Source:ZFIN;Acc:ZDB-GENE-010... [more]
evla5.565e-1434.51Enah/Vasp-like a [Source:ZFIN;Acc:ZDB-GENE-000607-... [more]
evla9.885e-1434.51Enah/Vasp-like a [Source:ZFIN;Acc:ZDB-GENE-000607-... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sorbs22.827e-1536.21sorbin and SH3 domain containing 2 [Source:Xenbase... [more]
sorbs23.634e-1536.21sorbin and SH3 domain containing 2 [Source:Xenbase... [more]
sorbs25.662e-1536.21sorbin and SH3 domain containing 2 [Source:Xenbase... [more]
sorbs26.212e-1536.52sorbin and SH3 domain containing 2 [Source:Xenbase... [more]
sorbs26.693e-1536.52sorbin and SH3 domain containing 2 [Source:Xenbase... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Enah1.112e-1533.87ENAH actin regulator [Source:MGI Symbol;Acc:MGI:10... [more]
Enah5.203e-1533.10ENAH actin regulator [Source:MGI Symbol;Acc:MGI:10... [more]
Enah5.769e-1533.10ENAH actin regulator [Source:MGI Symbol;Acc:MGI:10... [more]
Enah5.795e-1534.11ENAH actin regulator [Source:MGI Symbol;Acc:MGI:10... [more]
Enah6.498e-1534.11ENAH actin regulator [Source:MGI Symbol;Acc:MGI:10... [more]
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BLAST of WH1 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q03173|ENAH_MOUSE8.204e-1533.87Protein enabled homolog OS=Mus musculus OX=10090 G... [more]
sp|Q8T4F7|ENA_DROME1.371e-1435.71Protein enabled OS=Drosophila melanogaster OX=7227... [more]
sp|Q8N8S7|ENAH_HUMAN4.490e-1433.10Protein enabled homolog OS=Homo sapiens OX=9606 GN... [more]
sp|O08719|EVL_RAT4.613e-1331.11Ena/VASP-like protein OS=Rattus norvegicus OX=1011... [more]
sp|Q9UI08|EVL_HUMAN5.607e-1335.40Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=E... [more]
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BLAST of WH1 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3HT735.728e-1732.64protein enabled homolog OS=Lingula unguis OX=7574 ... [more]
A0A1S3J2Q94.797e-1632.00protein enabled homolog isoform X3 OS=Lingula ungu... [more]
A0A1S3J3X41.007e-1530.92protein enabled homolog isoform X1 OS=Lingula ungu... [more]
A0A1S3J3Y31.581e-1532.64protein enabled homolog isoform X6 OS=Lingula ungu... [more]
A0A1S3J2E21.611e-1532.64protein enabled homolog isoform X7 OS=Lingula ungu... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
enah5.171e-1531.97ENAH actin regulator [Source:NCBI gene;Acc:1030321... [more]
enah1.359e-1435.40ENAH actin regulator [Source:NCBI gene;Acc:1030321... [more]
enah1.756e-1435.71ENAH actin regulator [Source:NCBI gene;Acc:1030321... [more]
enah1.769e-1435.71ENAH actin regulator [Source:NCBI gene;Acc:1030321... [more]
enah1.928e-1435.71ENAH actin regulator [Source:NCBI gene;Acc:1030321... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000006730.11.389e-1535.04pep scaffold:Pmarinus_7.0:GL476423:313891:330988:1... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WH1 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO412084.474e-1736.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of WH1 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000036646.11.307e-1436.44vasodilator-stimulated phosphoprotein [Source:NCBI... [more]
evlb1.646e-1434.17ena/VASP-like protein [Source:NCBI gene;Acc:101159... [more]
ENSORLT00000006482.21.714e-1436.44vasodilator-stimulated phosphoprotein [Source:NCBI... [more]
evla6.925e-1435.34ena/VASP-like protein [Source:NCBI gene;Acc:101173... [more]
evla1.274e-1335.34ena/VASP-like protein [Source:NCBI gene;Acc:101173... [more]
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BLAST of WH1 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000052344.10.000e+095.71SMESG000052344.1[more]
SMESG000052344.10.000e+095.71SMESG000052344.1[more]
SMESG000052345.14.840e-3352.68SMESG000052345.1[more]
SMESG000052345.15.782e-3352.68SMESG000052345.1[more]
SMESG000063850.19.535e-1936.94SMESG000063850.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014250 ID=SMED30014250|Name=WH1 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1123bp
GAAGTATTTAATAAAAAATAATCAGATATCAATATTGAAATTTAGAAAGT
TTAAAGAAAAATAATTCTGAGTTCATTTTTGTGTAAATTTTCTGCAATGG
AACAGTCGATTATTAATACTAATGTAACAATATTGGAATATTGCAAATAC
AATTTCCAATGGAAAGAATTGGGATCAGTGAATGGAGAGAGTTCGCTAAC
TTTATACAGATCAAACATTAATACATATCGGTTTGTTGCTCATAAAATCT
TAAATGACGAGATAGTTCTAAATGCATTCCTATTTCCATCGATGCATTAC
AACGAGACGTCTCCAACATTCCATCAATGGATTGATAACTCCTTTTCAGT
TTATGGACTCAACTTTATAGATTCAAGTGAAGCAAAAAGATTCAGCTCAA
TCGTTGGCTTTGCCCTTCAATCACTCAATTCTGCACAGTCGACTGAAATG
AATTATTCAAGCACTAAAAGTTTACCAAGAAAAAAAAATGTGAAAATATG
TCCGCCGGAATTGCACCTTGAAAAAGGATACTCACATTCAAATTGTGAAA
TATCAAATTTCAAAGACAATTTCTCTTGGCAGTTAAGTTTTGATTCAAAA
CCTCACTTAAAAGCCAAATCAAAATCGTTTTGTATAGAACCTCGTGAAGT
TATTTTGAATACGTCGAGTGCTTTGCAAGTCAAAAAGAATTTGAAAGGCC
GAGAGGAGAAAAGTTCAAATCCAACGCAAATATTGGCTAAGGATATTTAT
GAAAAAACGAATCCACCGGTGAATTTATTAGCCGATATAAATGGAAAGTA
TAACAATAAATATTTTAAACATCCAATTCAACTCAATGATAATAATAATA
ATAAATGTTATTATTATCACTGTAGTGACGTTTCCACAAAGAAATTTACC
GGCCTAAAAACTGATCGATCATTACCATGCCCAAATTTATATAACACGAA
GCGGGCTACCTCTGAAGACCTTGAAACATTAAGAATACGCTTGACAACCG
ATGTAATTCATAATTTAGAAAGCATGAAGAAGGAAATAATTTCAAGTATT
GTTTACAATATGCGATAATGATATTCATCCTTGCAGGATTATTTTTATCC
AGAATGAAAACATTTCCTTTGTC
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protein sequence of SMED30014250-orf-1

>SMED30014250-orf-1 ID=SMED30014250-orf-1|Name=SMED30014250-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=324bp
MEQSIINTNVTILEYCKYNFQWKELGSVNGESSLTLYRSNINTYRFVAHK
ILNDEIVLNAFLFPSMHYNETSPTFHQWIDNSFSVYGLNFIDSSEAKRFS
SIVGFALQSLNSAQSTEMNYSSTKSLPRKKNVKICPPELHLEKGYSHSNC
EISNFKDNFSWQLSFDSKPHLKAKSKSFCIEPREVILNTSSALQVKKNLK
GREEKSSNPTQILAKDIYEKTNPPVNLLADINGKYNNKYFKHPIQLNDNN
NNKCYYYHCSDVSTKKFTGLKTDRSLPCPNLYNTKRATSEDLETLRIRLT
TDVIHNLESMKKEIISSIVYNMR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0046907intracellular transport
GO:0007391dorsal closure
GO:0007396suture of dorsal opening
GO:0007409axonogenesis
GO:0007411axon guidance
GO:0008064regulation of actin polymerization or depolymerization
GO:0008258head involution
GO:0008360regulation of cell shape
GO:0010591regulation of lamellipodium assembly
GO:0030036actin cytoskeleton organization
GO:0030335positive regulation of cell migration
GO:0031346positive regulation of cell projection organization
GO:0032956regulation of actin cytoskeleton organization
GO:0035262gonad morphogenesis
GO:0045886negative regulation of synaptic growth at neuromuscular junction
GO:0046847filopodium assembly
GO:0048749compound eye development
GO:0048813dendrite morphogenesis
GO:0051489regulation of filopodium assembly
GO:0051491positive regulation of filopodium assembly
GO:0060288formation of a compartment boundary
GO:1990255subsynaptic reticulum organization
GO:0003382epithelial cell morphogenesis
GO:0007010cytoskeleton organization
GO:0007015actin filament organization
GO:0007298border follicle cell migration
GO:0007303cytoplasmic transport, nurse cell to oocyte
GO:0007390germ-band shortening
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR000697WH1/EVH1_dom
IPR011993PH-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0017124SH3 domain binding
GO:0003779actin binding
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0030027lamellipodium
GO:0030424axon
GO:0030425dendrite
GO:0031252cell leading edge
GO:0032433filopodium tip
GO:0042995cell projection
GO:0071212subsynaptic reticulum
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005856cytoskeleton
GO:0005911cell-cell junction
GO:0005912adherens junction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000697WH1/EVH1 domainSMARTSM00461WH1_2coord: 2..107
e-value: 7.7E-5
score: 32.1
IPR000697WH1/EVH1 domainPFAMPF00568WH1coord: 3..103
e-value: 2.9E-15
score: 56.2
IPR000697WH1/EVH1 domainPROSITEPS50229WH1coord: 1..110
score: 14.271
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 1..117
e-value: 1.5E-19
score: 72.1
NoneNo IPR availablePANTHERPTHR11202VASODILATOR-STIMULATED PHOSPHOPROTEIN/SPROUTY PROTEIN EVH1 DOMAIN CONTAINING PROTEIN 3coord: 33..124
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 2..116