60S ribosomal protein L6
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014228 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Match: A0A1I8I3J0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017071g2 PE=4 SV=1) HSP 1 Score: 72.0182 bits (175), Expect = 4.738e-10 Identity = 34/80 (42.50%), Postives = 50/80 (62.50%), Query Frame = 3 Query: 120 FEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMTNE 356 F AF +D D G I++++LE Y + N KD F++KWLNLF DE I YD +C+TLG++P +E E +K+ T + Sbjct: 7 FHQAFQAIDTDHSGEISVEELEDYCKKMNYKDTFVKKWLNLFDEDESGTITYDEYCNTLGLIPKQEVVEK--HKVQQTKQ 84
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Match: A0A1I8HCC1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017071g1 PE=4 SV=1) HSP 1 Score: 72.0182 bits (175), Expect = 4.959e-10 Identity = 34/80 (42.50%), Postives = 50/80 (62.50%), Query Frame = 3 Query: 120 FEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMTNE 356 F AF +D D G I++++LE Y + N KD F++KWLNLF DE I YD +C+TLG++P +E E +K+ T + Sbjct: 7 FHQAFQAIDTDHSGEISVEELEDYCKKMNYKDTFVKKWLNLFDEDESGTITYDEYCNTLGLIPKQEVVEK--HKVQQTKQ 84
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Match: A0A4E0R6U0 (Putative tegumental protein OS=Fasciola hepatica OX=6192 GN=D915_005062 PE=4 SV=1) HSP 1 Score: 68.5514 bits (166), Expect = 6.789e-10 Identity = 47/176 (26.70%), Postives = 82/176 (46.59%), Query Frame = 3 Query: 105 IMNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGI-------VPAKEKFENKIYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKL-----NPSQEDLKVQYAEDG-----LLYYSPQSNDDKRILI 578 + D F AF +D+D DGVI I+DLE Y+ + F+QKW LF + I ++NFCSTLG+ + + E K+Y+ +M+ E+ +I + + ND ++++ +++ G +W + NP + Y+ D +LY P+ +K Sbjct: 1 MSQDTFLSAFENIDRDHDGVIHIRDLEEYAKNDGVSPDFVQKWKLLFDPNNTGQITFENFCSTLGVSKKVRDSAERRRRPEPKVYESNMSLESVDHCLQVIKRNYNHND--PDSSIHVTLTEMDGSLGPRWQARAVKLSENPKPAGEYLTYSLDNGEHKYVLYREPEKRRNKCCCC 174
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Match: A0A504X7T8 (Putative tegumental protein OS=Fasciola gigantica OX=46835 GN=FGIG_08761 PE=4 SV=1) HSP 1 Score: 68.5514 bits (166), Expect = 7.406e-10 Identity = 47/176 (26.70%), Postives = 83/176 (47.16%), Query Frame = 3 Query: 105 IMNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGI-------VPAKEKFENKIYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKL-----NPSQEDLKVQYAEDG-----LLYYSPQSNDDKRILI 578 + + F AF +D+D DGVI IQDLE Y+ + F+QKW LF + I ++NFCSTLG+ + + E K+Y+ +M+ E+ + +I + + ND ++++ +++ G +W + NP + Y+ D +LY P+ +K Sbjct: 1 MSQNTFLSAFENIDRDHDGVIHIQDLEEYAKNDGVSPDFVQKWKLLFDPNNTGQITFENFCSTLGVSKKVRDSAERRRRPEPKVYESNMSMESVEHCLQVIKRNYNYND--PDSSIHVTLTEMDGSLGPRWQARAVKLSENPKPAGEYLTYSLDNGEHKYVLYREPEKRRNKCCCC 174
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Match: A0A448XI69 (Uncharacterized protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS30542 PE=4 SV=1) HSP 1 Score: 65.855 bits (159), Expect = 2.570e-9 Identity = 26/64 (40.62%), Postives = 44/64 (68.75%), Query Frame = 3 Query: 120 FEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLFADEKNV-IYYDNFCSTLGIVPA 308 F+ AF+++D D G IT+++L Y + + ++ F+ KW+ LF EK I Y+++CSTLG++PA Sbjct: 4 FQRAFFEIDTDASGSITVEELRAYMEKMHYRETFVTKWVQLFDPEKTGEITYESYCSTLGLIPA 67
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Match: SMESG000050581.1 (SMESG000050581.1) HSP 1 Score: 508.449 bits (1308), Expect = 1.122e-179 Identity = 283/355 (79.72%), Postives = 311/355 (87.61%), Query Frame = 3 Query: 108 MNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLFADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSPQSNDDKRILIWKVENELEDPYEIYQXXXXXXXXXXXXXXXSEFKVKDKNLSKNTLDQITNKIANKTDGKWDIKINPNYESLSVKYSEDGILYYNPDNKDDLKILVWKISEELEDNNAV-IYDCDMTENIKTEILKLVHEKT-NENVVDNES---IISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNSIEQPKIFIWRQDKD 1157 MNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLFADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSP+SNDDKRILIWKVENELEDPYEIYQIDMTDKTKTTVIDIISEFKVKDKNLSKNTLDQITNKI+NKTDGKWDIKINPNYESLSVKYSEDGILYYNPDN+DDLKILVWKISEELED + I+ DMT+ K I++++++ +EN + +S I E+ + G W+++L+P+ + L Y DG + S N+ +I +W+ KD Sbjct: 1 MNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLFADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSPRSNDDKRILIWKVENELEDPYEIYQIDMTDKTKTTVIDIISEFKVKDKNLSKNTLDQITNKISNKTDGKWDIKINPNYESLSVKYSEDGILYYNPDNEDDLKILVWKISEELEDKDKFKIHVIDMTDKTKNSIMEILNKFVDDENDLSKDSLENIKKEIANQVGGDWDIKLDPSQRDLSTKYAEDGLVCLSRNNSNDLRILVWKVPKD 355 HSP 2 Score: 352.058 bits (902), Expect = 3.924e-118 Identity = 182/290 (62.76%), Postives = 238/290 (82.07%), Query Frame = 3 Query: 330 IYKIDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSPQSNDDKRILIWKVENELEDP--YEIYQXXXXXXXXXXXXXXXSEFKVKDKNLSKNTLDQITNKIANKTDGKWDIKINPNYESLSVKYSEDGILYYNPDNKDDLKILVWKISEELEDNNAVIYDCDMTENIKTEILKLVHEKTNENVVDNESIISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNSIEQPKIFIWRQDKDKKRGSLCCCGCF 1193 IY+IDMT++T ++ DIIS+ ++ +S+NTL++I N++ +W+IK+NP+ E L V+Y+EDG+LYY+P + DD +IL+WK+ ELED ++I+ IDMTDKTK ++++I+++F + +LSK++L+ I +IAN+ G WDIK++P+ LS KY+EDG++ + +N +DL+ILVWK+ ++ NAVIYDCDMTENIKTEILKLVHEKTNENVVDNESIISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNS EQPKIFIWRQDKDKKRGSLCCCGCF Sbjct: 170 IYQIDMTDKTKTTVIDIISEFKVKDKNLSKNTLDQITNKISNKTDGKWDIKINPNYESLSVKYSEDGILYYNPDNEDDLKILVWKISEELEDKDKFKIHVIDMTDKTKNSIMEILNKFVDDENDLSKDSLENIKKEIANQVGGDWDIKLDPSQRDLSTKYAEDGLVCLSRNNSNDLRILVWKVPKDPSITNAVIYDCDMTENIKTEILKLVHEKTNENVVDNESIISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNSTEQPKIFIWRQDKDKKRGSLCCCGCF 459
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Match: SMESG000017253.1 (SMESG000017253.1) HSP 1 Score: 109.383 bits (272), Expect = 4.326e-28 Identity = 60/169 (35.50%), Postives = 95/169 (56.21%), Query Frame = 3 Query: 114 DAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVPAKEKFENK--------IYK-IDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSPQSNDDKRILIWKVE 590 D F AF+Q+D D DG+I DL Y E NLK F +KWL+LF D +I+Y+ FC LGI +K ++ N ++K DM+N T +I I + + E+ ++ I ++ D+G WN+ +NP+++++K Y DG LYYSP ++L+W++E Sbjct: 2 DGFVSAFHQVDVDDDGIINEDDLNHYCEENNLKRNFTEKWLSLFDHDNDKIIHYEEFCRALGI-ESKRRYSNASAGNDDIVVFKETDMSNATKDAIIRKIYRKGKHEYNLKEDNIKDIIEELNMDHGPNWNVIVNPTEKEVKCCYDFDGKLYYSPNVKGKNKLLVWRIE 169 HSP 2 Score: 74.3294 bits (181), Expect = 1.984e-15 Identity = 39/106 (36.79%), Postives = 61/106 (57.55%), Query Frame = 3 Query: 888 DNNAVIYDCDMTENIKTEILKLVHEKTN-------ENVVDNESIISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNSIEQPKIFIWRQDKDKKRGSLCCC 1184 D+ V + DM+ K I++ ++ K +N+ D II EL+ G WN+ +NPT K++K YD DGK+Y+SPN + K+ +WR ++ KK+G CCC Sbjct: 78 DDIVVFKETDMSNATKDAIIRKIYRKGKHEYNLKEDNIKD---IIEELNMDHGPNWNVIVNPTEKEVKCCYDFDGKLYYSPNVKGKNKLLVWRIEEKKKKGLACCC 180
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Match: SMESG000017253.1 (SMESG000017253.1) HSP 1 Score: 109.383 bits (272), Expect = 4.469e-28 Identity = 60/169 (35.50%), Postives = 95/169 (56.21%), Query Frame = 3 Query: 114 DAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVPAKEKFENK--------IYK-IDMTNETHKSITDIISKLLDENDEISENTLEKIKNQVEYDNGSQWNIKLNPSQEDLKVQYAEDGLLYYSPQSNDDKRILIWKVE 590 D F AF+Q+D D DG+I DL Y E NLK F +KWL+LF D +I+Y+ FC LGI +K ++ N ++K DM+N T +I I + + E+ ++ I ++ D+G WN+ +NP+++++K Y DG LYYSP ++L+W++E Sbjct: 4 DGFVSAFHQVDVDDDGIINEDDLNHYCEENNLKRNFTEKWLSLFDHDNDKIIHYEEFCRALGI-ESKRRYSNASAGNDDIVVFKETDMSNATKDAIIRKIYRKGKHEYNLKEDNIKDIIEELNMDHGPNWNVIVNPTEKEVKCCYDFDGKLYYSPNVKGKNKLLVWRIE 171 HSP 2 Score: 74.3294 bits (181), Expect = 2.048e-15 Identity = 39/106 (36.79%), Postives = 61/106 (57.55%), Query Frame = 3 Query: 888 DNNAVIYDCDMTENIKTEILKLVHEKTN-------ENVVDNESIISELDKRFGETWNMQLNPTAKQLKVDYDLDGKIYFSPNSIEQPKIFIWRQDKDKKRGSLCCC 1184 D+ V + DM+ K I++ ++ K +N+ D II EL+ G WN+ +NPT K++K YD DGK+Y+SPN + K+ +WR ++ KK+G CCC Sbjct: 80 DDIVVFKETDMSNATKDAIIRKIYRKGKHEYNLKEDNIKD---IIEELNMDHGPNWNVIVNPTEKEVKCCYDFDGKLYYSPNVKGKNKLLVWRIEEKKKKGLACCC 182
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Match: SMESG000026622.1 (SMESG000026622.1) HSP 1 Score: 60.8474 bits (146), Expect = 9.226e-11 Identity = 30/80 (37.50%), Postives = 50/80 (62.50%), Query Frame = 3 Query: 114 DAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVPAKEKFENKIYKIDMT 350 D F AF+ +D D+ ITI +LE+Y NLKD F++KW+N+F +++ VI D +CS LG+V + + + + I+ + Sbjct: 2 DNFLTAFFNIDSDQSEEITIAELEKYMRLNNLKDAFVKKWINIFDSNDDGVITLDEYCSVLGLVTNEARIMREQFNIEHS 81
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Match: SMESG000019835.1 (SMESG000019835.1) HSP 1 Score: 62.003 bits (149), Expect = 1.660e-10 Identity = 27/63 (42.86%), Postives = 40/63 (63.49%), Query Frame = 3 Query: 120 FEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLF-ADEKNVIYYDNFCSTLGIVP 305 F AF +D+D G IT+ +L+ Y + N KD F+ KWL LF +++ I Y ++C TLG+VP Sbjct: 4 FHKAFEAIDEDGSGEITVDELQHYMIKNNYKDSFVSKWLTLFDSNQSGKITYKHYCDTLGLVP 66 The following BLAST results are available for this feature:
BLAST of 60S ribosomal protein L6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of 60S ribosomal protein L6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of 60S ribosomal protein L6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014228 ID=SMED30014228|Name=60S ribosomal protein L6|organism=Schmidtea mediterranea sexual|type=transcript|length=1222bpback to top protein sequence of SMED30014228-orf-1 >SMED30014228-orf-1 ID=SMED30014228-orf-1|Name=SMED30014228-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=363bp MNDAFEDAFYQLDQDRDGVITIQDLERYSTEKNLKDKFIQKWLNLFADEKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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