Peptidase S1 S6 chymotrypsin Hap active site isoform 2
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30014193 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Match: A0A4E0RRR4 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_000407 PE=4 SV=1) HSP 1 Score: 119.398 bits (298), Expect = 4.863e-28 Identity = 54/115 (46.96%), Postives = 78/115 (67.83%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 ++I NEHKSKCL + E+ AE C + I E + A+ N+S +S EYY ++ L+ YECK+L KL+CLY +LH+ C P+AV L++NYF ETLP C ++Y+++LQK ID Sbjct: 125 LRILNEHKSKCLARQEKVAEQCNVHRNDTIREVVAALQNQSSRLSTSSNEYYGLMRNTLSHYECKSLLAKLECLYAVLHTTCPPNAVRLVMNYFKETLPDGCTFNYEVRLQKHID 239
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Match: A0A183A5F8 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS2193 PE=4 SV=1) HSP 1 Score: 116.701 bits (291), Expect = 2.658e-27 Identity = 53/115 (46.09%), Postives = 76/115 (66.09%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 ++I NEHK+KCL + E+ AE C + I E + A+ N+S +S EYY ++ L+ YECK+L KL+CLY +LH+ C PDAV L++NYF ETLP C ++Y+ +LQ ID Sbjct: 91 LRILNEHKTKCLARQEKVAEQCNVHRNDTIREVVAALQNQSSQLSTSSNEYYGLMRKTLSHYECKSLLAKLECLYAVLHNTCPPDAVRLVMNYFKETLPDGCTFNYESRLQSHID 205
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Match: G7YX00 (Uncharacterized protein OS=Clonorchis sinensis OX=79923 GN=CLF_112788 PE=4 SV=1) HSP 1 Score: 110.538 bits (275), Expect = 6.180e-26 Identity = 46/108 (42.59%), Postives = 73/108 (67.59%), Query Frame = 1 Query: 331 IFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQL 654 +F EH++KCLL+ E+ +E C + I E + A+ N S + + EYY +++A L +YEC+ ++ KL+CL+ LL++ C PDA+ LI+NYF ETLP C +HY+ +L Sbjct: 22 VFREHQNKCLLKKEKASEQCTVVRNHTIREVVTALQNMSASVSAGSSEYYRSVQATLARYECRTIRSKLECLFNLLYTACPPDALRLIMNYFKETLPEGCTFHYENRL 129
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Match: A0A094ZUI5 (Uncharacterized protein OS=Schistosoma haematobium OX=6185 GN=MS3_06253 PE=4 SV=1) HSP 1 Score: 111.309 bits (277), Expect = 1.985e-25 Identity = 52/115 (45.22%), Postives = 75/115 (65.22%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 ++I EH+ +CL Q E+ AE C + I E ++A+ N+S SS EYY+ IK L YECK+L+ KLDCLY +LH+ C +AV LI+NYF ETLP C ++Y+ +L K ++ Sbjct: 100 LRILREHQYRCLKQQEKLAEQCAVHRNETIKEVVLALHNQSSRLLSSPNEYYSIIKHTLTSYECKSLRTKLDCLYNILHNACPSNAVRLIMNYFKETLPDGCTFNYETRLSKHLE 214
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Match: A0A430Q9H6 (Uncharacterized protein OS=Schistosoma bovis OX=6184 GN=DC041_0002792 PE=4 SV=1) HSP 1 Score: 110.538 bits (275), Expect = 2.061e-25 Identity = 52/115 (45.22%), Postives = 75/115 (65.22%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 ++I EH+ +CL Q E+ AE C + I E ++A+ N+S SS EYY+ IK L YECK+L+ KLDCLY +LH+ C +AV LI+NYF ETLP C ++Y+ +L K ++ Sbjct: 63 LRILREHQYRCLKQQEKLAEQCAVHRNETIKEVVLALHNQSSRLLSSPNEYYSIIKHTLTSYECKSLRTKLDCLYNILHNACPSNAVRLIMNYFKETLPDGCTFNYETRLSKHLE 177
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Match: SMESG000038428.1 (SMESG000038428.1) HSP 1 Score: 228.794 bits (582), Expect = 1.339e-76 Identity = 112/115 (97.39%), Postives = 114/115 (99.13%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 ++IFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKL CLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID Sbjct: 116 LRIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLGCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 230 HSP 2 Score: 76.6406 bits (187), Expect = 1.339e-76 Identity = 37/37 (100.00%), Postives = 37/37 (100.00%), Query Frame = 3 Query: 708 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML 818 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML Sbjct: 244 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML 280
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Match: SMESG000060842.1 (SMESG000060842.1) HSP 1 Score: 188.734 bits (478), Expect = 1.271e-64 Identity = 92/93 (98.92%), Postives = 92/93 (98.92%), Query Frame = 1 Query: 391 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKL CLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID Sbjct: 1 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLGCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 93 HSP 2 Score: 76.6406 bits (187), Expect = 1.271e-64 Identity = 37/37 (100.00%), Postives = 37/37 (100.00%), Query Frame = 3 Query: 708 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML 818 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML Sbjct: 107 YPFFERYKNDNSSVKMVKISIAIIFMNLGFLNLLEML 143
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Match: SMESG000060842.1 (SMESG000060842.1) HSP 1 Score: 189.504 bits (480), Expect = 8.371e-60 Identity = 92/93 (98.92%), Postives = 92/93 (98.92%), Query Frame = 1 Query: 391 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKL CLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID Sbjct: 1 MKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLGCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 93
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Match: SMESG000000812.1 (SMESG000000812.1) HSP 1 Score: 114.005 bits (284), Expect = 9.562e-30 Identity = 56/115 (48.70%), Postives = 73/115 (63.48%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 +Q+F HK +CL+Q E A C K K++ I E I A++N+SQ S +Y +K ILN YECK LK +L CLY +LH C P+AV LIL YF E LPSNC Y Y+ L +I+ Sbjct: 120 LQVFYTHKDRCLVQQETAANQCAKLKSATIEEAIKALANESQNLHSGHYQYSNYVKKILNNYECKGLKRQLKCLYNILHINCHPNAVHLILGYFREILPSNCEYVYEPMLTNYIN 234
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Match: SMESG000000812.1 (SMESG000000812.1) HSP 1 Score: 114.005 bits (284), Expect = 1.116e-29 Identity = 56/115 (48.70%), Postives = 73/115 (63.48%), Query Frame = 1 Query: 325 VQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKSQTSFSSQEEYYANIKAILNKYECKALKMKLDCLYELLHSRCSPDAVTLILNYFIETLPSNCYYHYQIQLQKFID 669 +Q+F HK +CL+Q E A C K K++ I E I A++N+SQ S +Y +K ILN YECK LK +L CLY +LH C P+AV LIL YF E LPSNC Y Y+ L +I+ Sbjct: 121 LQVFYTHKDRCLVQQETAANQCAKLKSATIEEAIKALANESQNLHSGHYQYSNYVKKILNNYECKGLKRQLKCLYNILHINCHPNAVHLILGYFREILPSNCEYVYEPMLTNYIN 235 The following BLAST results are available for this feature:
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Peptidase S1 S6 chymotrypsin Hap active site isoform 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30014193 ID=SMED30014193|Name=Peptidase S1 S6 chymotrypsin Hap active site isoform 2|organism=Schmidtea mediterranea sexual|type=transcript|length=818bpback to top protein sequence of SMED30014193-orf-1 >SMED30014193-orf-1 ID=SMED30014193-orf-1|Name=SMED30014193-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=152bp MSVSIGILLTVQIFNEHKSKCLLQNEREAESCMKFKASAINETIMAISNKback to top Annotated Terms
The following terms have been associated with this transcript:
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