RPTOR independent companion of MTOR, complex 2 a

Overview


Name	RPTOR independent companion of MTOR, complex 2 a
Smed ID	SMED30014131
Length (bp)	6177

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RPTOR independent companion of MTOR, complex 2 a (SMED30014131) t-SNE clustered cells

Violin plots show distribution of expression levels for RPTOR independent companion of MTOR, complex 2 a (SMED30014131) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RPTOR independent companion of MTOR, complex 2 a (SMED30014131) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30014131

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30014131	h1SMcG0006605	JN815259.1	smed_ncbi_20240424	PMID:22451003 González-Sastre et al., 2012
cephalic ganglia	SMED30014131	h1SMcG0006605	JN815259.1	smed_ncbi_20240424	PMID:22451003 González-Sastre et al., 2012
whole organism	SMED30014131	h1SMcG0006605	JN815259.1	smed_ncbi_20240424	PMID:22451003 González-Sastre et al., 2012
neoblast	SMED30014131	h1SMcG0006605	JN815259.1	smed_ncbi_20240424	PMID:22451003 González-Sastre et al., 2012
parenchyma	SMED30014131	h1SMcG0006605	JN815259.1	smed_ncbi_20240424	PMID:22451003 González-Sastre et al., 2012
gut	SMED30014131	h1SMcG0006605	SMED30014131	smed_20140614	PMID:22445864 Tu et al., 2012
cephalic ganglia	SMED30014131	h1SMcG0006605	SMED30014131	smed_20140614	PMID:22445864 Tu et al., 2012
whole organism	SMED30014131	h1SMcG0006605	SMED30014131	smed_20140614	PMID:22445864 Tu et al., 2012
parenchyma	SMED30014131	h1SMcG0006605	SMED30014131	smed_20140614	PMID:22445864 Tu et al., 2012

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
Match: RICTOR (RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol;Acc:HGNC:28611])

HSP 1 Score: 130.183 bits (326), Expect = 3.206e-29
Identity = 120/438 (27.40%), Postives = 217/438 (49.54%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ 1570
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++      S P    G        +  F ++ + I+ T F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F+ +L S+     G+ +  W L D F+  +    LPH + +R +++DNY A++L  F++  + E L   + + ++ IS RA ILL  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      +  L +IIQ+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS-PDTAEGQLKE--DREARFLASKMGIIAT-FRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-EEFIEALLSV---DPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQK 500

HSP 2 Score: 111.309 bits (277), Expect = 3.102e-26
Identity = 68/184 (36.96%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK                D L KL + SLDY+R  L R +LS  + +     R Y+TK L+VLLRA V FF++WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W + YN+ Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKY 839

HSP 3 Score: 30.0314 bits (66), Expect = 3.102e-26
Identity = 28/123 (22.76%), Postives = 52/123 (42.28%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P  + L  H YG +  HK G  +L  +  + E    +    +D+W  ++                     L++S+ A+ +I  S WGL  + E N+   + +L +     ++RG
Sbjct:  865 RRSNQRLQRPH-VYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKK--------------------LKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRG 966

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
Match: RICTOR (RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol;Acc:HGNC:28611])

HSP 1 Score: 130.183 bits (326), Expect = 3.256e-29
Identity = 120/438 (27.40%), Postives = 217/438 (49.54%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ 1570
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++      S P    G        +  F ++ + I+ T F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F+ +L S+     G+ +  W L D F+  +    LPH + +R +++DNY A++L  F++  + E L   + + ++ IS RA ILL  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      +  L +IIQ+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS-PDTAEGQLKE--DREARFLASKMGIIAT-FRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-EEFIEALLSV---DPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQK 500

HSP 2 Score: 111.309 bits (277), Expect = 3.481e-26
Identity = 68/184 (36.96%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK                D L KL + SLDY+R  L R +LS  + +     R Y+TK L+VLLRA V FF++WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W + YN+ Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKY 839

HSP 3 Score: 30.0314 bits (66), Expect = 3.481e-26
Identity = 28/123 (22.76%), Postives = 52/123 (42.28%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P  + L  H YG +  HK G  +L  +  + E    +    +D+W  ++                     L++S+ A+ +I  S WGL  + E N+   + +L +     ++RG
Sbjct:  865 RRSNQRLQRPH-VYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKK--------------------LKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRG 966

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
Match: RICTOR (RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol;Acc:HGNC:28611])

HSP 1 Score: 59.6918 bits (143), Expect = 1.167e-8
Identity = 54/184 (29.35%), Postives = 95/184 (51.63%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITH----SYWRSTVPIGYFN 829
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H     Y R+ V +  F+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELENFS 254

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
Match: RICTOR (RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol;Acc:HGNC:28611])

HSP 1 Score: 57.3806 bits (137), Expect = 5.607e-8
Identity = 50/167 (29.94%), Postives = 88/167 (52.69%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITH 790
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H
Sbjct:   76 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNH 221

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Celegans
Match: rict-1 (pep chromosome:WBcel235:II:13098250:13116806:-1 gene:WBGene00009245.1 transcript:F29C12.3b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rict-1)

HSP 1 Score: 67.781 bits (164), Expect = 1.059e-10
Identity = 38/129 (29.46%), Postives = 69/129 (53.49%), Query Frame = 2

Query: 2228 FTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEIL 2614
            F   +L+Y  S      IG  +++  G +IL   G ++++   L  +     TK+I+ SLDYT   + R ++  A+ S +  +R+++T++L VL    +P FS WG+ ++++QL D    V +    IL
Sbjct:  791 FAARNLSYTNSMLHFAIIGTFTMTSKGLSILTNAGVLHMYVDILSSTSQLEYTKVIISSLDYTNEGMVRVIIGKALTSTSEASRKWTTRYLAVLASFDLPTFSDWGIQYMLRQLADESSKVVRHTIRIL 919

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Celegans
Match: rict-1 (pep chromosome:WBcel235:II:13098249:13116806:-1 gene:WBGene00009245.1 transcript:F29C12.3a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rict-1)

HSP 1 Score: 67.781 bits (164), Expect = 1.095e-10
Identity = 38/129 (29.46%), Postives = 69/129 (53.49%), Query Frame = 2

Query: 2228 FTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEIL 2614
            F   +L+Y  S      IG  +++  G +IL   G ++++   L  +     TK+I+ SLDYT   + R ++  A+ S +  +R+++T++L VL    +P FS WG+ ++++QL D    V +    IL
Sbjct:  789 FAARNLSYTNSMLHFAIIGTFTMTSKGLSILTNAGVLHMYVDILSSTSQLEYTKVIISSLDYTNEGMVRVIIGKALTSTSEASRKWTTRYLAVLASFDLPTFSDWGIQYMLRQLADESSKVVRHTIRIL 917

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Celegans
Match: rict-1 (pep chromosome:WBcel235:II:13098249:13110236:-1 gene:WBGene00009245.1 transcript:F29C12.3c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rict-1)

HSP 1 Score: 60.077 bits (144), Expect = 1.707e-8
Identity = 32/103 (31.07%), Postives = 58/103 (56.31%), Query Frame = 2

Query: 2306 GETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEIL 2614
            G +IL   G ++++   L  +     TK+I+ SLDYT   + R ++  A+ S +  +R+++T++L VL    +P FS WG+ ++++QL D    V +    IL
Sbjct:    5 GLSILTNAGVLHMYVDILSSTSQLEYTKVIISSLDYTNEGMVRVIIGKALTSTSEASRKWTTRYLAVLASFDLPTFSDWGIQYMLRQLADESSKVVRHTIRIL 107

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Fly
Match: rictor (gene:FBgn0031006 transcript:FBtr0343635)

HSP 1 Score: 88.9669 bits (219), Expect = 4.667e-17
Identity = 65/234 (27.78%), Postives = 105/234 (44.87%), Query Frame = 2

Query: 2120 MYSNLKDCLLSIADEKYIQEIKDNFGF----NKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            + SN  +C+  I D  Y  +I          N+ ++ C    ++  N  C  Y  L IGRM  +  G  +L+           +  +      KLI+  L+Y+   L R +L  A+ S     R YST+F+ VLLRA++P F  WG+  ++ Q  D DR V  AA ++L EA  D+  +  ++       H+   G +L +R  SLP   +    +  +   +  W+  YN  Y
Sbjct:  656 LSSNELECMRFITD--YFSDISQQLAAVTTSNRAHD-CLFSPQHMNNTMCQQYF-LYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRY 883

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Fly
Match: rictor (gene:FBgn0031006 transcript:FBtr0074689)

HSP 1 Score: 88.9669 bits (219), Expect = 4.674e-17
Identity = 65/234 (27.78%), Postives = 105/234 (44.87%), Query Frame = 2

Query: 2120 MYSNLKDCLLSIADEKYIQEIKDNFGF----NKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            + SN  +C+  I D  Y  +I          N+ ++ C    ++  N  C  Y  L IGRM  +  G  +L+           +  +      KLI+  L+Y+   L R +L  A+ S     R YST+F+ VLLRA++P F  WG+  ++ Q  D DR V  AA ++L EA  D+  +  ++       H+   G +L +R  SLP   +    +  +   +  W+  YN  Y
Sbjct:  668 LSSNELECMRFITD--YFSDISQQLAAVTTSNRAHD-CLFSPQHMNNTMCQQYF-LYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRY 895

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Fly
Match: rictor (gene:FBgn0031006 transcript:FBtr0343634)

HSP 1 Score: 88.9669 bits (219), Expect = 4.822e-17
Identity = 65/234 (27.78%), Postives = 105/234 (44.87%), Query Frame = 2

Query: 2120 MYSNLKDCLLSIADEKYIQEIKDNFGF----NKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            + SN  +C+  I D  Y  +I          N+ ++ C    ++  N  C  Y  L IGRM  +  G  +L+           +  +      KLI+  L+Y+   L R +L  A+ S     R YST+F+ VLLRA++P F  WG+  ++ Q  D DR V  AA ++L EA  D+  +  ++       H+   G +L +R  SLP   +    +  +   +  W+  YN  Y
Sbjct:  648 LSSNELECMRFITD--YFSDISQQLAAVTTSNRAHD-CLFSPQHMNNTMCQQYF-LYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRY 875

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Match: rictorb (RPTOR independent companion of MTOR, complex 2b [Source:ZFIN;Acc:ZDB-GENE-070810-5])

HSP 1 Score: 129.798 bits (325), Expect = 2.510e-29
Identity = 106/368 (28.80%), Postives = 187/368 (50.82%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            L +++K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +K   L T L+ VI   D +  R+N    EA++ T L L+ H + R  V       + L P++     +  P    G        +  F ++ +SI+ +L +SWSG++ L  S N  I SL GLL +    +R  +L++++++F +  P  T  DFV +L S+      + +  W L D F+  +    LPH + +R +++DNY A+LL  F+   + E L   +    + +S RA ILL  +
Sbjct:   61 LLNEAKEVRAAGLRSLRYLIRDSNILQKVLRLQVDYLISRCIDI----------QQSNEVERTQALRLVRKMITVNALLFPSSVANSLIAVGNDGPQER----DRMVRACIAIICELALENPEIVAKRGGLSTILKNVI---DCQLSRIN----EALMTTILHLLNHPHTRQYVRSDVELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFLASKMSIVASL-RSWSGIINLCKSGNSGIQSLIGLLCIPNMEVRRGLLEVMYEIFRLPVPVVT-QDFVEALLSV---DPSRFQDSWRLSDGFVASEAKIILPHRARSRPDLMDNYLALLLSAFIHSGLLEGLVEVITSSEDSVSVRATILLGEL 399

HSP 2 Score: 113.235 bits (282), Expect = 5.193e-26
Identity = 71/203 (34.98%), Postives = 104/203 (51.23%), Query Frame = 2

Query: 2201 NKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            +++ ++ G+ T    +Y       L +G +S +  G  +LEK                D L KL++ +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + V   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  612 DRSLQSNGLLTTLSQHY------FLFLGTLSANPQGVKMLEKCSVFQCLLNLCSLKNQDHLLKLVVSTLDYSRDGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDRSKAVSVEALDILDEACEDKANLHALIHMKPALTHLGDKGVLLLLRFLSIPKGFSYLNERGYVSKQLEKWQKEYNLKY 808

HSP 3 Score: 26.9498 bits (58), Expect = 5.193e-26
Identity = 26/111 (23.42%), Postives = 48/111 (43.24%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVS 3168
            R SN+   +P ++ L  H YG +   K G  +L  +  + +    +    +D+W  ++                     L++++ A+ +I  S WGL  + E N IP IV+
Sbjct:  834 RRSNQRLQRP-NVFLPVHLYGQLVHDKTGCHLLEAQNVVSDLSYTVRCPLLDKWEGIKQ--------------------LKAALWALGNIGTSNWGLNLLQEENVIPDIVA 923

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Match: rictorb (RPTOR independent companion of MTOR, complex 2b [Source:ZFIN;Acc:ZDB-GENE-070810-5])

HSP 1 Score: 129.413 bits (324), Expect = 2.982e-29
Identity = 106/368 (28.80%), Postives = 187/368 (50.82%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            L +++K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +K   L T L+ VI   D +  R+N    EA++ T L L+ H + R  V       + L P++     +  P    G        +  F ++ +SI+ +L +SWSG++ L  S N  I SL GLL +    +R  +L++++++F +  P  T  DFV +L S+      + +  W L D F+  +    LPH + +R +++DNY A+LL  F+   + E L   +    + +S RA ILL  +
Sbjct:   41 LLNEAKEVRAAGLRSLRYLIRDSNILQKVLRLQVDYLISRCIDI----------QQSNEVERTQALRLVRKMITVNALLFPSSVANSLIAVGNDGPQER----DRMVRACIAIICELALENPEIVAKRGGLSTILKNVI---DCQLSRIN----EALMTTILHLLNHPHTRQYVRSDVELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFLASKMSIVASL-RSWSGIINLCKSGNSGIQSLIGLLCIPNMEVRRGLLEVMYEIFRLPVPVVT-QDFVEALLSV---DPSRFQDSWRLSDGFVASEAKIILPHRARSRPDLMDNYLALLLSAFIHSGLLEGLVEVITSSEDSVSVRATILLGEL 379

HSP 2 Score: 113.235 bits (282), Expect = 1.983e-26
Identity = 69/184 (37.50%), Postives = 96/184 (52.17%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L +G +S +  G  +LEK                D L KL++ +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + V   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  605 SQHYFLFLGTLSANPQGVKMLEKCSVFQCLLNLCSLKNQDHLLKLVVSTLDYSRDGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDRSKAVSVEALDILDEACEDKANLHALIHMKPALTHLGDKGVLLLLRFLSIPKGFSYLNERGYVSKQLEKWQKEYNLKY 788

HSP 3 Score: 28.1054 bits (61), Expect = 1.983e-26
Identity = 31/107 (28.97%), Postives = 47/107 (43.93%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVS 3168
            R SN+   +P ++ L  H YG +   K G  +L    + Q C VV           D+        L   E    L++++ A+ +I  S WGL  + E N IP IV+
Sbjct:  814 RRSNQRLQRP-NVFLPVHLYGQLVHDKTGCHLL----EAQVCNVV----------SDLSYTVRCPLLDKWEGIKQLKAALWALGNIGTSNWGLNLLQEENVIPDIVA 905

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Match: rictora (RPTOR independent companion of MTOR, complex 2 a [Source:ZFIN;Acc:ZDB-GENE-060526-49])

HSP 1 Score: 127.102 bits (318), Expect = 1.399e-28
Identity = 105/368 (28.53%), Postives = 188/368 (51.09%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            L ++ K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++ +LFP S+ N+L  +   GSD      D  +R  + I+C+L +  P+  ++   L T L+ VI   D +  R+N    EA++ T L L+ H + R  +       + L P++      +    E+    +    +  F ++ ++I+   F+SWSG++ L  S N  + SL GLL +    +R  +L++L+++F +  P  T  DF  +L S+      + +  W L D F+  +    LPH + +R +++DNY A+LL  F+   + E L   V   +  IS RA ILL  +
Sbjct:   79 LLNEVKEVRAAGLRALRYLIRDSSILQKVLQLQVDYLISRCIDI----------QQSNEVERTQALRLVRKMITVNAQLFPSSVTNSLIAV---GSDGLQE-RDRMVRACIAIICELALKNPEVVAQRGGLSTILKNVI---DCQLSRIN----EALITTILHLLNHPHTRQFIRADVELEQILAPYTDFHYRHNPETAEAQIKEDR---EARFLASKMAIVAA-FRSWSGIINLCKSGNSGVQSLIGLLCIPNMDVRKALLEVLYEIFRLPVPLVT-GDFEEALHSV---DPSRFQDSWRLSDGFVAAEAKVILPHRARSRPDLMDNYLALLLSAFINSGLLEGLVEVVTSSDGQISVRATILLGEL 417

HSP 2 Score: 110.153 bits (274), Expect = 1.641e-26
Identity = 71/202 (35.15%), Postives = 102/202 (50.50%), Query Frame = 2

Query: 2204 KTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            ++  + G+ T  + +Y       L +G +S    G  +LEK G              D L KL + +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W K YN  Y
Sbjct:  632 RSLHSNGLLTTLNQHY------FLFLGTLSAQPHGVKMLEKCGVFQCLLNLCSMKNQDHLLKLTVSTLDYSRDGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGMELLVTQLHDHNKTISMEALDILDEACEDKANLHALIHMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVSKQLEKWLKEYNLKY 827

HSP 3 Score: 31.9574 bits (71), Expect = 1.641e-26
Identity = 30/124 (24.19%), Postives = 56/124 (45.16%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P ++ L  H YG +   K G  +L  +G + +    +    +D+W  ++                     L++++ A+ +I  S WGL  ++E N IP I++ L Q     ++RG
Sbjct:  853 RRSNQRLQRP-NVFLPVHLYGQLVHDKTGCLLLEAQGVIPDLSYTVRSPVLDKWEGVKQ--------------------LKAALWALGNIGSSNWGLNLLLEENVIPDIIA-LAQHCEVLSIRG 954

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Match: rictora (RPTOR independent companion of MTOR, complex 2 a [Source:ZFIN;Acc:ZDB-GENE-060526-49])

HSP 1 Score: 127.102 bits (318), Expect = 1.534e-28
Identity = 105/368 (28.53%), Postives = 188/368 (51.09%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            L ++ K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++ +LFP S+ N+L  +   GSD      D  +R  + I+C+L +  P+  ++   L T L+ VI   D +  R+N    EA++ T L L+ H + R  +       + L P++      +    E+    +    +  F ++ ++I+   F+SWSG++ L  S N  + SL GLL +    +R  +L++L+++F +  P  T  DF  +L S+      + +  W L D F+  +    LPH + +R +++DNY A+LL  F+   + E L   V   +  IS RA ILL  +
Sbjct:   99 LLNEVKEVRAAGLRALRYLIRDSSILQKVLQLQVDYLISRCIDI----------QQSNEVERTQALRLVRKMITVNAQLFPSSVTNSLIAV---GSDGLQE-RDRMVRACIAIICELALKNPEVVAQRGGLSTILKNVI---DCQLSRIN----EALITTILHLLNHPHTRQFIRADVELEQILAPYTDFHYRHNPETAEAQIKEDR---EARFLASKMAIVAA-FRSWSGIINLCKSGNSGVQSLIGLLCIPNMDVRKALLEVLYEIFRLPVPLVT-GDFEEALHSV---DPSRFQDSWRLSDGFVAAEAKVILPHRARSRPDLMDNYLALLLSAFINSGLLEGLVEVVTSSDGQISVRATILLGEL 437

HSP 2 Score: 109.383 bits (272), Expect = 2.943e-26
Identity = 72/202 (35.64%), Postives = 104/202 (51.49%), Query Frame = 2

Query: 2204 KTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            ++  + G+ T  + +Y       L +G +S    G  +LEK G  +L          D L KL + +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W K YN  Y
Sbjct:  652 RSLHSNGLLTTLNQHY------FLFLGTLSAQPHGVKMLEKCGVFHLLN-LCSMKNQDHLLKLTVSTLDYSRDGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGMELLVTQLHDHNKTISMEALDILDEACEDKANLHALIHMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVSKQLEKWLKEYNLKY 846

HSP 3 Score: 31.5722 bits (70), Expect = 2.943e-26
Identity = 32/124 (25.81%), Postives = 57/124 (45.97%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRG---DLQECL-VVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P ++ L  H YG +   K G  +L  +G   DL   +   ++D+W  ++                     L++++ A+ +I  S WGL  ++E N IP I++ L Q     ++RG
Sbjct:  872 RRSNQRLQRP-NVFLPVHLYGQLVHDKTGCLLLEAQGVIPDLSYTVRSPVLDKWEGVKQ--------------------LKAALWALGNIGSSNWGLNLLLEENVIPDIIA-LAQHCEVLSIRG 973

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Match: rictorb (RPTOR independent companion of MTOR, complex 2b [Source:ZFIN;Acc:ZDB-GENE-070810-5])

HSP 1 Score: 65.855 bits (159), Expect = 1.258e-10
Identity = 64/231 (27.71%), Postives = 115/231 (49.78%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSG 979
            L +++K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +K   L T L+ VI   D +  R+N    EA++ T L L+ H + R  V       + L P++     +  P    G        +  F ++ +SI+ +L +SWSG
Sbjct:   92 LLNEAKEVRAAGLRSLRYLIRDSNILQKVLRLQVDYLISRCIDI----------QQSNEVERTQALRLVRKMITVNALLFPSSVANSLIAVGNDGPQER----DRMVRACIAIICELALENPEIVAKRGGLSTILKNVI---DCQLSRIN----EALMTTILHLLNHPHTRQYVRSDVELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFLASKMSIVASL-RSWSG 297

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
Match: smarcc1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [Source:Xenbase;Acc:XB-GENE-5906750])

HSP 1 Score: 109.768 bits (273), Expect = 1.030e-26
Identity = 71/187 (37.97%), Postives = 99/187 (52.94%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDY---SRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK    N+F+  L+       D L KL +  LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + +   A +IL EA ED+A ++ LI    A  H    G +L  R +S+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEK---CNVFQCLLNLCSLKNQDHLLKLAISCLDYSRDGLARVILSKTLTASTDSCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDKSKNISSEAVDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFMSIPKGFSYLNERGYVTKQLEKWQKEYNLKY 839

HSP 2 Score: 33.4982 bits (75), Expect = 1.030e-26
Identity = 37/122 (30.33%), Postives = 57/122 (46.72%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELI--LRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+ + +P  + L  H YG +  HK G  +L       E  V  M+E   +R   +           D+ + I  L++++ A+ +I  S WGL  + E N IP IVS L Q     ++RG
Sbjct:  865 RRSNQRQQRPH-VYLPVHLYGQLVYHKTGCHLL-------EVQVRAMNEGYTVRSPSL-----------DKWDGIKQLKAALWALGNIGSSNWGLNLLQEENVIPDIVS-LAQHCDVLSIRG 966

HSP 3 Score: 119.783 bits (299), Expect = 4.104e-26
Identity = 116/443 (26.19%), Postives = 215/443 (48.53%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTIN 1585
            L +++K VR A LR LRY + +   ++  L +++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N L  +   G        D  +R  + ILC+L +L P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++     +  P    G        +  F+++ + I+   F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F  +L S+      + +  W L D F+  +    LPH + +R +++DNY A++L  F+   + E L   +   ++ +S RA I+L  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      + +L +I+Q+  T +
Sbjct:   92 LLNEAKEVRAAGLRALRYLIRDSSILQKVLTLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSITNTLIAVGNDGLQER----DRMVRACIAILCELALLNPEVVALRGGLSTILKNVI---DCQLSRIN----EALITTVLHLLNHPDTRQYVRADIELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFQASKLGIVAA-FRSWAGIISLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-KEFTEALLSV---DPSRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALVLSAFITNGLLEGLVEVITSSDDDVSVRATIILGELLHIANTILPHSHSHHLHCLPTLMNLAASFDIPKEKRLWASAALNCLKRFHEMKKRGPKPYSLYLDHIVQKAVTTH 505

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
Match: smarcc1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [Source:Xenbase;Acc:XB-GENE-5906750])

HSP 1 Score: 109.768 bits (273), Expect = 1.109e-26
Identity = 71/187 (37.97%), Postives = 99/187 (52.94%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDY---SRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK    N+F+  L+       D L KL +  LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + +   A +IL EA ED+A ++ LI    A  H    G +L  R +S+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  637 SQHYFLFIGTLSCHPHGVKMLEK---CNVFQCLLNLCSLKNQDHLLKLAISCLDYSRDGLARVILSKTLTASTDSCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDKSKNISSEAVDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFMSIPKGFSYLNERGYVTKQLEKWQKEYNLKY 820

HSP 2 Score: 33.113 bits (74), Expect = 1.109e-26
Identity = 32/124 (25.81%), Postives = 56/124 (45.16%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+ + +P  + L  H YG +  HK G  +L  +  + +    +    +D+W+ ++                     L++++ A+ +I  S WGL  + E N IP IVS L Q     ++RG
Sbjct:  846 RRSNQRQQRPH-VYLPVHLYGQLVYHKTGCHLLEVQNVVPDLSYTVRSPSLDKWDGIKQ--------------------LKAALWALGNIGSSNWGLNLLQEENVIPDIVS-LAQHCDVLSIRG 947

HSP 3 Score: 119.783 bits (299), Expect = 3.995e-26
Identity = 116/443 (26.19%), Postives = 215/443 (48.53%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTIN 1585
            L +++K VR A LR LRY + +   ++  L +++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N L  +   G        D  +R  + ILC+L +L P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++     +  P    G        +  F+++ + I+   F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F  +L S+      + +  W L D F+  +    LPH + +R +++DNY A++L  F+   + E L   +   ++ +S RA I+L  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      + +L +I+Q+  T +
Sbjct:   73 LLNEAKEVRAAGLRALRYLIRDSSILQKVLTLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSITNTLIAVGNDGLQER----DRMVRACIAILCELALLNPEVVALRGGLSTILKNVI---DCQLSRIN----EALITTVLHLLNHPDTRQYVRADIELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFQASKLGIVAA-FRSWAGIISLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-KEFTEALLSV---DPSRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALVLSAFITNGLLEGLVEVITSSDDDVSVRATIILGELLHIANTILPHSHSHHLHCLPTLMNLAASFDIPKEKRLWASAALNCLKRFHEMKKRGPKPYSLYLDHIVQKAVTTH 486

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
Match: smarcc1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [Source:Xenbase;Acc:XB-GENE-5906750])

HSP 1 Score: 109.768 bits (273), Expect = 1.128e-26
Identity = 71/187 (37.97%), Postives = 99/187 (52.94%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDY---SRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK    N+F+  L+       D L KL +  LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + +   A +IL EA ED+A ++ LI    A  H    G +L  R +S+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEK---CNVFQCLLNLCSLKNQDHLLKLAISCLDYSRDGLARVILSKTLTASTDSCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDKSKNISSEAVDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFMSIPKGFSYLNERGYVTKQLEKWQKEYNLKY 839

HSP 2 Score: 33.113 bits (74), Expect = 1.128e-26
Identity = 32/124 (25.81%), Postives = 56/124 (45.16%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+ + +P  + L  H YG +  HK G  +L  +  + +    +    +D+W+ ++                     L++++ A+ +I  S WGL  + E N IP IVS L Q     ++RG
Sbjct:  865 RRSNQRQQRPH-VYLPVHLYGQLVYHKTGCHLLEVQNVVPDLSYTVRSPSLDKWDGIKQ--------------------LKAALWALGNIGSSNWGLNLLQEENVIPDIVS-LAQHCDVLSIRG 966

HSP 3 Score: 119.783 bits (299), Expect = 4.138e-26
Identity = 116/443 (26.19%), Postives = 215/443 (48.53%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTIN 1585
            L +++K VR A LR LRY + +   ++  L +++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N L  +   G        D  +R  + ILC+L +L P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++     +  P    G        +  F+++ + I+   F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F  +L S+      + +  W L D F+  +    LPH + +R +++DNY A++L  F+   + E L   +   ++ +S RA I+L  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      + +L +I+Q+  T +
Sbjct:   92 LLNEAKEVRAAGLRALRYLIRDSSILQKVLTLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSITNTLIAVGNDGLQER----DRMVRACIAILCELALLNPEVVALRGGLSTILKNVI---DCQLSRIN----EALITTVLHLLNHPDTRQYVRADIELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFQASKLGIVAA-FRSWAGIISLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-KEFTEALLSV---DPSRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALVLSAFITNGLLEGLVEVITSSDDDVSVRATIILGELLHIANTILPHSHSHHLHCLPTLMNLAASFDIPKEKRLWASAALNCLKRFHEMKKRGPKPYSLYLDHIVQKAVTTH 505

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
Match: smarcc1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [Source:Xenbase;Acc:XB-GENE-5906750])

HSP 1 Score: 109.768 bits (273), Expect = 1.287e-26
Identity = 71/187 (37.97%), Postives = 99/187 (52.94%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDY---SRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK    N+F+  L+       D L KL +  LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD  + +   A +IL EA ED+A ++ LI    A  H    G +L  R +S+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEK---CNVFQCLLNLCSLKNQDHLLKLAISCLDYSRDGLARVILSKTLTASTDSCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDKSKNISSEAVDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFMSIPKGFSYLNERGYVTKQLEKWQKEYNLKY 839

HSP 2 Score: 33.113 bits (74), Expect = 1.287e-26
Identity = 32/124 (25.81%), Postives = 56/124 (45.16%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVSRLTQFHPSFNVRG 3207
            R SN+ + +P  + L  H YG +  HK G  +L  +  + +    +    +D+W+ ++                     L++++ A+ +I  S WGL  + E N IP IVS L Q     ++RG
Sbjct:  865 RRSNQRQQRPH-VYLPVHLYGQLVYHKTGCHLLEVQNVVPDLSYTVRSPSLDKWDGIKQ--------------------LKAALWALGNIGSSNWGLNLLQEENVIPDIVS-LAQHCDVLSIRG 966

HSP 3 Score: 119.783 bits (299), Expect = 3.593e-26
Identity = 116/443 (26.19%), Postives = 215/443 (48.53%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTIN 1585
            L +++K VR A LR LRY + +   ++  L +++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N L  +   G        D  +R  + ILC+L +L P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++     +  P    G        +  F+++ + I+   F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F  +L S+      + +  W L D F+  +    LPH + +R +++DNY A++L  F+   + E L   +   ++ +S RA I+L  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      + +L +I+Q+  T +
Sbjct:   92 LLNEAKEVRAAGLRALRYLIRDSSILQKVLTLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSITNTLIAVGNDGLQER----DRMVRACIAILCELALLNPEVVALRGGLSTILKNVI---DCQLSRIN----EALITTVLHLLNHPDTRQYVRADIELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFQASKLGIVAA-FRSWAGIISLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-KEFTEALLSV---DPSRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALVLSAFITNGLLEGLVEVITSSDDDVSVRATIILGELLHIANTILPHSHSHHLHCLPTLMNLAASFDIPKEKRLWASAALNCLKRFHEMKKRGPKPYSLYLDHIVQKAVTTH 505

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Mouse
Match: Rictor (RPTOR independent companion of MTOR, complex 2 [Source:MGI Symbol;Acc:MGI:1926007])

HSP 1 Score: 129.798 bits (325), Expect = 2.395e-29
Identity = 120/438 (27.40%), Postives = 218/438 (49.77%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ 1570
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++      S P    G        +  F ++ + I+ T F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F+ +L S+     G+ +  W L D F+  +    LPH + +R +++DNY A++L  F++  + E L   + + ++ IS RA ILL  + +  + +LP  H      L +  N +  F+ PK ++     AL  +++ H++ +      +  L +IIQ+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS-PDTAEGQLKE--DREARFLASKMGIIAT-FRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-DEFIEALLSV---DPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQK 500

HSP 2 Score: 112.464 bits (280), Expect = 6.854e-27
Identity = 69/184 (37.50%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK                D L KL + SLDY+R  L R +LS  + +     R Y+TK L+VLLRA V FF++WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W K YN+ Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKY 839

HSP 3 Score: 30.8018 bits (68), Expect = 6.854e-27
Identity = 32/121 (26.45%), Postives = 55/121 (45.45%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELI--LRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P  + L  H YG +  HK G  +L       E   +I +  + +R  D+           D+ E I  L++S+ A+ +I  S WGL  + E N+   + +L +     ++RG
Sbjct:  865 RRSNQRLQRPH-VYLPVHLYGQLVHHKTGCHLL-------EVQSIITELCHNVRTPDL-----------DKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRG 966

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. UniProt/SwissProt
Match: sp|Q6R327|RICTR_HUMAN (Rapamycin-insensitive companion of mTOR OS=Homo sapiens OX=9606 GN=RICTOR PE=1 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 1.539e-28
Identity = 120/438 (27.40%), Postives = 217/438 (49.54%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ 1570
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++      S P    G        +  F ++ + I+ T F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F+ +L S+     G+ +  W L D F+  +    LPH + +R +++DNY A++L  F++  + E L   + + ++ IS RA ILL  + +  + +LP  H      L +  N +  F+ PK ++     AL  + + H++ +      +  L +IIQ+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS-PDTAEGQLKE--DREARFLASKMGIIAT-FRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-EEFIEALLSV---DPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQK 500

HSP 2 Score: 111.309 bits (277), Expect = 1.383e-25
Identity = 68/184 (36.96%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK                D L KL + SLDY+R  L R +LS  + +     R Y+TK L+VLLRA V FF++WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W + YN+ Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKY 839

HSP 3 Score: 30.0314 bits (66), Expect = 1.383e-25
Identity = 28/123 (22.76%), Postives = 52/123 (42.28%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P  + L  H YG +  HK G  +L  +  + E    +    +D+W  ++                     L++S+ A+ +I  S WGL  + E N+   + +L +     ++RG
Sbjct:  865 RRSNQRLQRPH-VYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKK--------------------LKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRG 966

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. UniProt/SwissProt
Match: sp|Q6QI06|RICTR_MOUSE (Rapamycin-insensitive companion of mTOR OS=Mus musculus OX=10090 GN=Rictor PE=1 SV=2)

HSP 1 Score: 129.798 bits (325), Expect = 1.675e-28
Identity = 120/438 (27.40%), Postives = 218/438 (49.77%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHP-----LSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ 1570
            L +++K VR A LR LRY + +   ++  LK+++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  +    L T L+ VI   D +  R+N    EA++ T L L+ H   R  V       + L P++      S P    G        +  F ++ + I+ T F+SW+G++ L    N  I SL G+L +    IR  +L++L+ +F +  P  T  +F+ +L S+     G+ +  W L D F+  +    LPH + +R +++DNY A++L  F++  + E L   + + ++ IS RA ILL  + +  + +LP  H      L +  N +  F+ PK ++     AL  +++ H++ +      +  L +IIQ+
Sbjct:   92 LLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI----------QQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQER----DRMVRACIAIICELALQNPEVVALRGGLNTILKNVI---DCQLSRIN----EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS-PDTAEGQLKE--DREARFLASKMGIIAT-FRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVT-DEFIEALLSV---DPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQK 500

HSP 2 Score: 112.464 bits (280), Expect = 4.191e-26
Identity = 69/184 (37.50%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L IG +S    G  +LEK                D L KL + SLDY+R  L R +LS  + +     R Y+TK L+VLLRA V FF++WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W K YN+ Y
Sbjct:  656 SQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKY 839

HSP 3 Score: 30.8018 bits (68), Expect = 4.191e-26
Identity = 32/121 (26.45%), Postives = 55/121 (45.45%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELI--LRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P  + L  H YG +  HK G  +L       E   +I +  + +R  D+           D+ E I  L++S+ A+ +I  S WGL  + E N+   + +L +     ++RG
Sbjct:  865 RRSNQRLQRPH-VYLPVHLYGQLVHHKTGCHLL-------EVQSIITELCHNVRTPDL-----------DKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRG 966

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. UniProt/SwissProt
Match: sp|O77203|PIAA_DICDI (Protein pianissimo A OS=Dictyostelium discoideum OX=44689 GN=piaA PE=1 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 1.605e-12
Identity = 52/161 (32.30%), Postives = 79/161 (49.07%), Query Frame = 2

Query: 2279 IGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNG 2761
            +G +S + +G  IL +    +  K   +    D L+ LI+ SLDY      R++L   + S +   R  +TK+L+ LLR+ V  FS+WGV  L++QL+D D  V   +  +L EA +D + +  LI      L     G  L  R LS P   + L   NG
Sbjct:  701 LGTLSSNLLGLEILARNNIFDYIKPLAELPGRDDLSHLIMTSLDYNVNGASRTILQKILTSSSRVVRYLATKYLRFLLRSGVQDFSNWGVELLVQQLNDVDAKVSALSLNVLDEACDDPSCLEVLIDLKPNLLKLGKPGKSLLLRFLSSPKGLENLLQNNG 861

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Match: H9XVZ8 (Rictor (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1054.28 bits (2725), Expect = 0.000e+0
Identity = 546/616 (88.64%), Postives = 547/616 (88.80%), Query Frame = 2

Query: 1061 GRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNY-------------------------------RVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVXXXXXXXXXXXXXXFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 2815
            GRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFL                                     ALESAVADDNELISSRAGILLANISYKVSIL PADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNY                               R+GALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVESSKESEISEELNEFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ
Sbjct:    1 GRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFL-------------------------------------ALESAVADDNELISSRAGILLANISYKVSILFPADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYEFICLAEALQILEQDSITFREFNEIIHRNQKRIGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVESSKESEISEELNEFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 579

HSP 2 Score: 608.216 bits (1567), Expect = 0.000e+0
Identity = 363/370 (98.11%), Postives = 364/370 (98.38%), Query Frame = 2

Query: 4358 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKLRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMXXXXXXXXXXXXXXXXXRCXXXXXXXXXXHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKXXXXXXXXXXXXXEPRCCDQMDQSLVGIFSNIRKTXXXXXXXXXXXXXXXFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYEC 5467
            TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSK RRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKT     +DPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYEC
Sbjct:  725 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKHRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKT-----NDPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYEC 1089

HSP 3 Score: 368.237 bits (944), Expect = 7.661e-101
Identity = 175/175 (100.00%), Postives = 175/175 (100.00%), Query Frame = 2

Query: 5468 VDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQ 5992
            VDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQ
Sbjct: 1172 VDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQ 1346

HSP 4 Score: 278.485 bits (711), Expect = 5.084e-72
Identity = 130/130 (100.00%), Postives = 130/130 (100.00%), Query Frame = 1

Query: 2818 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG
Sbjct:  595 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 724

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Match: C3ZJ41 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_70035 PE=4 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 2.450e-60
Identity = 232/858 (27.04%), Postives = 391/858 (45.57%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTLQTVICNQDGKAWRLNF-------RIIEAVLLTQLKLITHSYWRSTVPIGYFNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFE--STSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPAD-----HPLSSKTNASVLFN-----NPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVXXXXXXXXXXXXXXFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            L S+ K +R A LR  RY++ +   +EL L++++DFLI R LD++           S+D ER+ A+RL+ ++  +SP LFP SL+N L  +   GS     +L  ++            +  + A  N +      V+    G    LN        RI E+++ T L LI     R  V      + L PF+      +    +S     +++   E    S+ ++I  T+F+SW G++ L   +   + SL G+L +  + +R  I+D+LF +F +  P  T  DF  +L+S ++ ST ++   W L   F+V +    LP    +R N+I+NY  ++L  F+   + E+L   +   +   S RA +LL  + +  + LLP +     H L S  N +  F+       ++  A++ ++++H+L +      + +L  +++    +              PA+              S+++ +Q S  +     N      L Q ++ + +   I ++    SWDWDL+ V  +  V     L  D  + +R ++ L+ F+  K    N  YSG  L  +      LT         V   ++ +L+      +  EE + F+  +   + +CL  + D       KD+          G+F++  L         L IGR+S    GE +LE  G    F +       D L KLI+  LDY++  L R +LS A+ +    +R Y+T FL+VLLRA+VPFF+ WGV FL+ QL+D  +VV   A +IL EA E+EA ++ L+    + LH    G +L  R LS+   F  L   N     LD W K++N  Y
Sbjct:   90 LLSERKEIRAAGLRVFRYFLKDAATMELLLRLKVDFLIARCLDIA----------QSNDGERVQALRLIRKMVYVSPSLFPCSLVNTLVAVGNEGSQERDRLLRASL-----------CVLCELAIHNPL------VVSRCGGVGTILNHILDCHLARINESLMATVLHLINQPQTRCYVRAIELQQMLAPFTDFHYRHNADTPDS-----HINDARETTLLSSKMAI-ATIFRSWPGVVVLCKPDGSGVESLLGVLCIPNNEVRKGIMDILFDIFRLPIPSWT-EDFTVALKS-SDPSTFQD--TWQLSQGFVVEEAKSILPSRMSSRTNLIENYLGLVLSAFLNAGLLESLVEVIRSSDNHNSVRATVLLGELLHMANRLLPHECGQHSHCLPSLVNLAASFDVSAQERQRASTAVMCLNRLHELKKRGPVPHSLYLDQLMRHGHRL--------------PAH--------------SSSRMAQVSREKLAQYLNKDTDETLQQAMKDTQVL--ITKENL--SWDWDLIAVVLKLSVGGPRWL--DDAANARFVRRLVFFYRPK----NLLYSGLKLDSSLVEPRKLT--------IVGCQLMEFLL------DCQEEGHRFVEEVIREVVECLCEVYDG------KDD----------GLFSDQSLQTSVCQDFFLLIGRLSRLQAGEKVLEASGVYQCFMSICGLKGCDLLRKLIIACLDYSKDGLARVVLSKALTAPAESSRLYATSFLRVLLRARVPFFNQWGVEFLVTQLYDKSKVVAMEAIDILDEACEEEANLHALVDMRPSLLHLGDKGAMLLIRFLSISKGFTFLSEVNYTANVLDKWYKSFNKKY 842

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Match: K1PHU1 (Rapamycin-insensitive companion of mTOR OS=Crassostrea gigas OX=29159 GN=CGI_10004570 PE=4 SV=1)

HSP 1 Score: 222.246 bits (565), Expect = 3.341e-59
Identity = 224/890 (25.17%), Postives = 400/890 (44.94%), Query Frame = 2

Query:  188 VAYLNILVYLSKDLLQEYDN---KGLXXXXXXXXXXXXLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTLQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILS-KIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPAD--HPLSSKTNASVLFNNP--------KSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRV-IQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVXXXXXXXXXXXXXXFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            +AYLN LV     L+ +Y N    GL    I   ++  L+ ++K VR A LR LRY++     V+L   + +D+LI+RS+D+S +N +          ERIHA++L+ R+  I+PK     L+  L  I   G+     ++ IA+            L       + IL     + C+Q         RI E+++ T L L+ H   R  +       + L PF+    +  +E + +S    +    +H F ++ ++++ ++ ++WSG++     +   + SL G+L +    IR  IL++LF LF + + P    DF ++L S+      +N   W+L D F+  +    LPH++  R N+I+N+ A+LL  ++   I EAL   +   +  +  RA I+L ++ +  S +LPA+  H      +   L ++P        ++++A+  + ++H + +      + +L  +IQ++    V     Q+K +L+    D +++            P++  + Q   +          Q++   +I            W+WDL+             L   +E + R+  Q+++KFF          Y   N   ++     L + H      V +   C LV+    +E  E     L  + +++  C+  IA ++ + E               + +  ++   CS +  L +GR S + IG+  LEK G        +  +  D+  KL + SL+Y+R    R +L+ A+ S     R Y TKFL+ LLRA+V  FSSWG+  L+ QL+D    V QAA  +L EA + +  +N++I      LH    G +L  R +S    F  L + N +   +  W+K YN  Y
Sbjct: 2781 LAYLNALV----KLVLKYGNDKYSGLSKRDILCCLRLGLFHEAKEVRAAVLRVLRYFLQESETVDLLYSLHIDYLIVRSIDISLDNEV----------ERIHAIKLVRRILQIAPKKLSDLLLYPLVAISNDGTGERDRMVRIALETICETAFVNPELLARCGGISAILRA--ALDCHQYP-------RINESLVATILHLLNHPRTRHFIKFNTDLEQLLAPFTDCHYRFSAESLEQS----SGEEKEHRFAASKMAVI-SIMRTWSGIIRFCRPDASGLQSLVGILYLPYKEIRHGILEILFDLFRL-KIPELTEDFNTALLSVDPSDIQEN---WSLTDGFVAEEGKCILPHMAKIRPNLIENHLALLLSAWIGAGILEALIEVIISSDRQLFVRATIILGDLLHLASTMLPAECTHHNHCLPSLLALASSPDLTSAQTYQAREAIYNLERLHSMKKRGPVPCSLYLDQLIQRNGGRPVG----QTKFYLR-KKYDLLIN----------KSPTEDMIGQAIRD---------SQVIGTKDIVH----------WEWDLIPAI----------LKWPEEKVRRLDDQIILKFFKRLV----HFYKPTNHRFSR-----LEFGHRLGQKMVHSG--CLLVDFLLSTEQDEVQKLAL-DLINDIGGCMSEIAQQRLVPE--------------SVLSPGNVINTCSQFYFLFVGRFSGTIIGDKYLEKTGVYQYLLDIVSIAPQDSFVKLTVSSLNYSRDGNTRPVLAKALCSATESARLYCTKFLRTLLRARVAGFSSWGMELLVNQLYDQSNQVAQAALHVLEEACDIQPCLNSVIKLRPQCLHLGERGVLLLCRFMSTAKGFKMLSDANFILNEVQKWEKTYNVRY 3568

HSP 2 Score: 40.0466 bits (92), Expect = 3.341e-59
Identity = 28/109 (25.69%), Postives = 52/109 (47.71%), Query Frame = 1

Query: 2881 RDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            +D  +  H YG +++HK G  +L +    QEC+         L       E H+     DE  L +++++ A+ HI  S WG+ ++ E  +   + +L +    F++RG
Sbjct: 3602 KDAYVPVHLYGQLTQHKEGFSLLQQ----QECISEFFQCIKCL-------ELHS-----DEDVLKMKTALWAVGHIGTSTWGVTWLEEERLLPEIIKLAEESGVFSIRG 3694

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Match: A0A210PEL5 (Rapamycin-insensitive companion of mTOR OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT08698 PE=4 SV=1)

HSP 1 Score: 220.705 bits (561), Expect = 2.083e-58
Identity = 237/932 (25.43%), Postives = 421/932 (45.17%), Query Frame = 2

Query:   74 ENCFETTKINLNDGPVFNFVKIFTALSDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLXXXXXXXXXXXXLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTLQTVICNQDGKAWRLNF------RIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPAD-----HPLSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQ---SKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVXXXXXXXXXXXXXXFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            E+  E  K++L+  P  N  +I T ++  ++ +     + YLN  V L   L ++  + G     I   ++ SL+ ++K VR A LR LRY++ +   ++L  K+ +D+LI+RS+D+  +N +          ERIHA++L+ R++ ++P     SLI  L  I   G+D +    D  +R  L  +C++  L P+  +K           C   G   R         RI E+++ T L L+ H   R  +       + L PF+     +      S + G     ++ F ++ ++I+ ++ +SW G++     +   + SL G+L +    IR  I+++L+ LF +  P  T  +F ++L S+        R  W L D F+  +    LPH++  R N+++N+ A+LL  ++   I +AL   V    + +  R  ILL  + +  S LLP +     H L +    +   N P+ Q+     A+ ++ ++H + +      + +L ++I+       N  G +   SK F Q  N    L+S Y+      NK S   +  QT   +        Q++   + F          +WDWDL+    +  +D +  L  D++ LSR ++ L+ FF  K T               F+ L +  K +T  A       C L+E   E    +    F + + +++  CL  +  +    E               + +  +    CS +  L +G++SV+  G+ +LEK G        +  +  D+  KL +  L Y++    R++L+ A+ +     R Y TKFL+VLLR +VP FS+WG+  L  QL+D  R +  AA  ++ EA E +  +N+LI    + LH    G ++  R +S    F  L + N V   L+ W+K +N  Y
Sbjct:   22 ESGEEGVKLDLSKDPGENIKEILTVVT-VQLHVHKTKKLGYLNAFVKLLYKLGKQ-KSLGYSKQDILCCLRVSLFHEAKEVRAATLRVLRYFIQDGETLDLLYKLHIDYLIVRSIDMCLDNEV----------ERIHAIKLVRRIAQLAPHKLTCSLIYPLVAI---GNDGASE-RDRMVRVCLSTICEIAFLNPELVAK-----------CGGVGSILRAALDCHQYPRINESLVCTILHLLNHPRTRHLIKFNTDLEQLLAPFTDC-HYRYSGAETSDHSGE--DKENRFSASKMAIV-SIMRSWPGIIRFCRPDGSGLQSLVGILYLPYYEIRQGIVEILYDLFRLQIPEWT-DNFSTALLSVDPSMM---RDSWRLTDGFICEEGRSVLPHMAKIRPNLVENHLALLLSAWIGAGILDALVEVVISSEDQLFVRTTILLGQLMHMASTLLPNECSHHSHCLPTLMAMASAANIPQQQQHRACNAVSYLDRLHSMKKRGIVPCSLYLDHLIK-------NMGGRKSPFSKHFHQNKN---RLNSYYI------NKLSSEDMVMQTIKDS--------QVLYTKDNF----------TWDWDLIASILKWPLDKQKKL--DEQMLSRFMKRLIYFF--KPTN------------HLFSRLEVGHKLATKIAHA----GCLLMEFLMECGQEDVKKHF-VDLINDIGQCLSEVGSQHLAAE--------------AVLSPSNTINTCSQFYFLFLGKISVTAKGDKLLEKCGIYQYLLDIVSVAPQDSFVKLTVSCLSYSQEGNCRAILTKALCASTESARMYCTKFLRVLLRVRVPGFSTWGMELLTTQLYDQSRNISLAALGVMEEACEIDTCLNSLIKLRPSCLHLGEKGRLVTCRFMSTSRGFRNLMDANYVSNELEIWEKTFNIKY 849

HSP 2 Score: 38.891 bits (89), Expect = 2.083e-58
Identity = 30/108 (27.78%), Postives = 51/108 (47.22%), Query Frame = 1

Query: 2884 DLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            D  L  H YG +++ K G  +L +    QEC   I + +  +R  +         L  DE    L++++ A+ HI  S WG+ ++ E  +   V RL +    F++RG
Sbjct:  884 DAFLPVHLYGQLTQTKEGFQLLRQ----QEC---IEEYFQCIRCQE---------LMTDEDNTKLKTALWAVGHIGSSTWGVNWLDEERLFSEVIRLAEECGVFSIRG 975

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Match: X2A9R0 (Uncharacterized protein OS=Capitella teleta OX=283909 PE=4 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 1.402e-56
Identity = 219/852 (25.70%), Postives = 370/852 (43.43%), Query Frame = 2

Query:  299 SDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTLQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQH-EFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADH-----------PLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDS--WDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAANSSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVXXXXXXXXXXXXXXFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNYKCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            + +K +R A LR LRYY+     V+  +K+ + FLI RSLD+  +N I          ERIHAMRL+  ++ I P  FP  L+  L  I + G+  S  +L I++     +         +    + IL ++         +  R+N    EA+L T L L+ H   R  + +     + L PF+        P  ++     ++  +   F +  ++I  T  +SW G++ L       + SL G L       +  I+D+L+ +F +  P  T  +F  +L S+   +    R  W L + F+  +    LPHL+  R N++DN+ ++LL  F+   + EAL   +   +E  S RA ILL  +++  + ++PA+             L+S    S    N ++  AL  + ++H L +      + FL +++Q     +  D    S R L+    D +L S                      NK + + A    +  ++++  S       D+  WDW LL    +   +S   L  D + + R I+ L+ FF       N  ++   LS  +  L+  +  H  +      +               ++  +FL    +++  CL  + + +   ++  + GF              L + CS +  L +GR S S  GE +LE  G   +          D   KLIL S+DYTR  L R LL+  + S N   R Y+ ++L VLLRA VPFFSSWG+  L  QL+D  + V   A  +L EA E+E  + +L+    + LH    G +L +R +S+P  +  L +   +   LD W++ +N  Y
Sbjct:   84 TSAKEMRAACLRALRYYIQEAEDVDALIKLNIHFLIARSLDICLDNEI----------ERIHAMRLIRHVAHIVPTAFPPVLLPPLVAIVIDGAKESDKMLSISLATLCELALTCPQTVAEVGGISAILRSIL-----DSSQMPRIN----EALLSTILFLLNHPRTRHFIRVNIDLEQMLAPFT--DNHYHRPEGDASKDQAFLEEREGRFTACKMAIA-TCMRSWPGIIRLCRPEGSGLQSLLGALYQPHMDTKKEIMDILYTVFCLPVPKWT-DNFSEALLSVDASAM---RDSWRLIEGFVAEEGLHILPHLARTRSNLVDNHLSLLLATFINAGLLEALVEVITTSHEKTSVRAIILLGELNHMANSIIPAECNQYNLYLPSLVSLASSFQVSAEKRN-RASLALSCLSRMHALKKRGVVPCSLFLNHLMQSVHQRSSED----SSRPLKVTR-DGLLSSI---------------------NKVFMLPAHYCIVTEHTSMINSPAVLLTKDNINWDWHLLCSLLKWPDESMQRL--DDQLVQRFIRRLIFFFK----PTNKLFAAVELSRLEHTLMGCSGMHLVDFLLECNN---------------DDATKFLTEWLTDIAQCLTEVKECRSSLDVLFSPGF--------------LQHTCSQFYFLFLGRCSASPQGEKLLESTGIYQVMLDLCSAGSQDVYVKLILSSMDYTRDGLSRLLLTKGLTSTNESARLYAVQWLHVLLRAHVPFFSSWGLELLNAQLYDQSKAVALEALSVLSEACEEEVNLMSLVRLQPSLLHLGKKGAMLLARFVSVPQGYKFLMDSGLLQTELDKWRQGFNVQY 847

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Cavefish
Match: rictorb (RPTOR independent companion of MTOR, complex 2b [Source:ZFIN;Acc:ZDB-GENE-070810-5])

HSP 1 Score: 111.309 bits (277), Expect = 8.809e-26
Identity = 68/184 (36.96%), Postives = 95/184 (51.63%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L +G +S    G  +LEK                D L KL + +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFS+WG+  L+ QLHD ++ +   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W+K YN  Y
Sbjct:  504 SQHYFLFLGTLSAHPNGVKLLEKCSVFQCLLNLCSLKNQDHLLKLTVSTLDYSRDGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGIELLVTQLHDRNKAISMEALDILDEACEDKANLHALIQLKPALTHLGDKGVLLLLRFLSIPKGFSYLNERGYVSKQLEKWQKEYNLKY 687

HSP 2 Score: 27.7202 bits (60), Expect = 8.809e-26
Identity = 28/111 (25.23%), Postives = 49/111 (44.14%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRG---DLQECL-VVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMN-IPLIVS 3168
            R SN+   +P ++ L  H YG +   K G ++L  +    DL   +   ++D W  ++                     L++++ A+ +I  S WGL  + E N IP IV+
Sbjct:  713 RRSNQRLQRP-NVYLPVHLYGQLVHDKTGCNLLEAQNVVPDLSYTVRSPVLDTWEGIKQ--------------------LKAALWALGNIGTSNWGLNLLQEENVIPDIVT 802

HSP 3 Score: 93.2041 bits (230), Expect = 3.026e-18
Identity = 84/294 (28.57%), Postives = 146/294 (49.66%), Query Frame = 2

Query:  515 ISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            ++ +LFP S+ N+L  +   G        D  +R  + I+C+L +  P+  ++   L T L+ VI   D +  R+N    EA++ T L L+ H + R  V       + L P++     +  P    G        +  F ++ +SI+ + F+SWSG++ L  S +  I SLTGLL +    +R  +L++L+ +F +  P  T  DF+ +L S+      + +  W L D F+  +    LPH + +R +++DNY A++L  F+   + E L   V   ++ IS RA ILL  +
Sbjct:    4 VNAQLFPSSITNSLIAVGNDGLQER----DRMVRACIAIICELALKNPEIVARRGGLKTILKNVI---DCQLSRIN----EALMTTILHLLNHPHTRQYVRSDVELEQILAPYTDF-HYRHNPDTAEGQLKE--DREARFLASKMSIVAS-FRSWSGIINLCKSGSSGIQSLTGLLCIPNMEVRRGLLEVLYDIFRLPVPVVT-QDFIEALLSV---DPSRFQDSWRLSDGFVASEAKIILPHRARSRPDLMDNYLALVLSAFINSGLLEGLVEVVTSSDDNISVRATILLGEL 278

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Cavefish
Match: rictora (RPTOR independent companion of MTOR, complex 2 a [Source:ZFIN;Acc:ZDB-GENE-060526-49])

HSP 1 Score: 117.087 bits (292), Expect = 1.660e-25
Identity = 70/184 (38.04%), Postives = 97/184 (52.72%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L +G +S   +G   +EK G      +       DAL KL + +LDY+R  L R +LS  + + +   R Y+TK L+VLLRA V FFS+WG+  L  QLHD  +VV   A +IL EA E++A ++ LI    A  H    G +L  R LS+P  F  L  +  V   L+ W K YN  Y
Sbjct:  602 SQHYFLFLGTLSAQPLGVKTMEKCGVFQCLLSLCSLKNQDALLKLTVSTLDYSRDGLARVILSKILTAGSDVCRLYATKHLRVLLRANVEFFSNWGIELLAIQLHDLSKVVSMEALDILDEACEEKANLHALIHMKPALTHLGDKGLLLQLRFLSIPKGFSYLNERGYVSKQLEKWSKEYNLKY 785

HSP 2 Score: 110.153 bits (274), Expect = 1.917e-23
Identity = 95/346 (27.46%), Postives = 175/346 (50.58%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDS--SGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTL-QTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFE 1318
            L ++ K VR A LR  RY + +   ++  L++++D+LI R +D+          + S++ ER  A+RLL ++  +   LFP S+ N+L  +   G+D    G+ + +A      I+C+L +  P+  +    L TL + V+ +Q         RI EA++ T L L+ H + R  V       + L P++      +    E+    +    +  F ++ ++I+ + F+SWSG++ L  + N  I SL GLL +    +R  +L++L+++F +  P  T TDF  +L+SI      + +  W L D F+  +    LPH + +R +++DNY A++L   +   + E
Sbjct:   55 LLNEVKEVRAAGLRAFRYLIRDKAVLQKLLQLQVDYLISRCIDI----------QQSNEVERTQALRLLRKIIAVDAALFPGSVTNSLVAV---GNDGLHEGDRMVLA---CNAIICELALRNPEVVAGRGGLSTLLKNVLDSQQS-------RINEALITTVLHLLNHPHTRQYVRSDVELEQILAPYTDFHYRHNPDTTEAQLKKDR---EARFLASKMAIVAS-FRSWSGIINLCKAGNSGIQSLIGLLCIPNMEVRKALLEVLYEIFRLPVPMVT-TDFEEALQSI---DPSRLQDSWRLGDGFVAAEAKVILPHRTRSRPDLMDNYLALILSTLINSGLLE 369

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Nematostella
Match: EDO33699 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRE9])

HSP 1 Score: 123.25 bits (308), Expect = 4.631e-28
Identity = 123/454 (27.09%), Postives = 208/454 (45.81%), Query Frame = 2

Query:  305 SKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICL--SGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT----LQTVICNQ-DGKAWRLNFRIIEAVLLTQLKLITHS----YWRSTVPIGYFNKTLTPFSIL----SKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPAD-----HPLSSKTNASVLFNNPKSQK-----ALLWIHQVHQLLEHHQFEITPFLTYIIQQ----HPT 1579
            +K VR A +R LR+   +    E  LK+R+D  I+RS+D    N I N+       ERI A+R + ++  + PK  P SL      +CL  +GSD+S             +    L    + A KN  L +    +  +I N  D +  RLN    EA+++T L L+ +S    Y RS V +      L PF+ L    +   SE +F+          +    ++ ++I+  +F+SWSG++     + K + SL G+  +  S +R  I+D++ Q+F I +   T  DF  +L S+        +  W L + F+  +  D LPH +  R N++ NY A++L  F+   + E L   +   +  IS +A ILL  + +  + LLP +     H L S  N +  F    +++     A+  + ++HQ+ +      + +L  I  Q    HP 
Sbjct:    9 AKEVRAAGVRALRHLFSDKTTFEKMLKVRMDIFIIRSMD----NTIANE------VERIQALRFIRKVVAVCPKSCPMSL-----AVCLVSTGSDNS--------EEPDRLKTACLATLCELAIKNSALASYSGGINAIIRNVLDCQVPRLN----EALMVTLLFLLNNSDSRPYVRSDVGL---EGVLAPFTDLHYRHNADTSEKLFKE-------DREARLRASEMAII-AVFRSWSGIISFCKPDGKGLQSLLGVFCLKNSEVRRGIMDIISQIFRIKQAVWT-DDFNIALMSVDPSVM---QDTWRLQENFVAQEGKDLLPHRATGRTNLVSNYTALVLAAFMNAGLLECLVEVITSSDCFISVQATILLGELLHLANTLLPPECSRHSHCLPSLVNTATSFEVSAAERGRASAAVNCLDRLHQMKKREPVPCSLYLEQIFNQRVSAHPA 420

HSP 2 Score: 99.7525 bits (247), Expect = 3.287e-26
Identity = 63/198 (31.82%), Postives = 101/198 (51.01%), Query Frame = 2

Query: 2222 GIFTEYDLNYKCSSYLILAIGRMSVS--DIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            G+ +   L    S   IL +GR+S S       +LEK                + L KLI+ SLDY    + R +LS  + + ++ TR Y+T  ++VLLR+KV FF++WG+ FL+ QL+D +  V   A ++L EA EDEA +  L+      LH    G  L +R +++   F  LQ+   ++  L+ W++ +   Y
Sbjct:  559 GVLSSSSLQNTLSRDYILFLGRISCSKNSTSSKLLEKTDIYQYLLEMCSTPGQENLLKLIIASLDYKDTGISRIILSKLLTASSVSTRLYATSHMRVLLRSKVLFFNNWGMEFLVTQLYDTETQVANEAADVLDEACEDEANLQYLVQLRPVLLHLGERGIRLMTRFVAVERGFTYLQSLGYLHVLLEQWRQKFCREY 756

HSP 3 Score: 39.2762 bits (90), Expect = 3.287e-26
Identity = 28/133 (21.05%), Postives = 59/133 (44.36%), Query Frame = 1

Query: 2809 LPKVNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            L      +D+    R S + K   +D  L  H YG + + K G  +L K  D++ C+  I           ++ +T    +++       ++++ A+ H   S WG+  ++E ++   + R+ +   +F +RG
Sbjct:  768 LTTYTKATDEESYVRRSTRRK-TVKDCFLPPHLYGKLVQKKNGFKLLQKTNDIELCVRTIQT---------LEPDTREKVIEI-------KAALWALGHCGSSNWGITLLMEEDVIPDIVRMAEESENFAIRG 883

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Medaka
Match: rictora (RPTOR independent companion of MTOR complex 2 [Source:NCBI gene;Acc:101161162])

HSP 1 Score: 127.487 bits (319), Expect = 1.001e-28
Identity = 105/368 (28.53%), Postives = 185/368 (50.27%), Query Frame = 2

Query:  293 LWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANI 1390
            L +++K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  I   G        D  +R A+ I+C+L +  P+  +K   L T L++VI   D +  R+N    EA++ T L L+ H   R  V       + L PF+      +    E     +    +  F S+ ++I+   F+SWSG++ L    N  I SL GLL +    +R  +L++ +++F +  P  T  DF  +L+S+      + +  W L D F+  +    L H + +R +++DNY A +L  F+   + E L   V   ++ +S RA ILL ++
Sbjct:   39 LLNEAKEVRAAGLRALRYLIRDTCVLQKVLRLQVDYLISRCIDI----------QQSNEGERTQALRLVRKIISVNAMLFPTSITNSLIAIGTDGLQER----DRMVRAAIAIVCELALKNPEVVAKRGGLSTILKSVI---DCQLSRIN----EALITTILHLLNHPCTRQYVRTDVELEQILAPFTDFHYRHNADTAEGQIKEDR---EARFLSSRMAIVAA-FRSWSGIINLCKDENSGIQSLIGLLCIPNMEVRKGLLEVFYEIFRLPIPIAT-QDFAEALQSV---DPARFQDTWRLSDGFVAAEAKVVLLHRARSRPDLMDNYLAFVLSAFISSGLLEGLVEVVTSSDDQLSIRATILLGDL 377

HSP 2 Score: 119.013 bits (297), Expect = 2.793e-28
Identity = 74/184 (40.22%), Postives = 97/184 (52.72%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L +G +S    G  +LEK G              DAL KL + +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFSSWG+  L+ QLHD  +VV   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   LD W+K YN  Y
Sbjct:  603 SQHYFLFLGTLSPHPQGVKLLEKCGLFQCLLNLCSIKNQDALLKLAVTTLDYSRDGLARVILSKVLTAATDTCRLYATKHLRVLLRAGVEFFSSWGMELLVTQLHDHSKVVSIEALDILDEACEDKANLHALIQLKPAVSHLGDKGLLLLLRFLSIPKGFSYLNERGYVSKQLDKWQKEYNLKY 786

HSP 3 Score: 28.8758 bits (63), Expect = 2.793e-28
Identity = 29/123 (23.58%), Postives = 50/123 (40.65%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P ++ L  H YG +   K G  +L  +  + +    I    +D W  ++                     L++S+ A+ +I  S WGL  + E N+   +  L Q     +VRG
Sbjct:  812 RRSNQRLQRP-NVYLPVHLYGQLVHDKTGCHLLEAQNVVPDLSYTIRSPMLDTWEGIKQ--------------------LKASLWALGNIGSSNWGLNLLQEENVIPDILVLAQHCEVLSVRG 913

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Medaka
Match: rictora (RPTOR independent companion of MTOR complex 2 [Source:NCBI gene;Acc:101161162])

HSP 1 Score: 112.464 bits (280), Expect = 1.920e-26
Identity = 74/187 (39.57%), Postives = 101/187 (54.01%), Query Frame = 2

Query: 2258 SSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDY---SRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLY 2809
            S +  L +G +S    G  +LEK   + +  + L+       DAL KL + +LDY+R  L R +LS  + +     R Y+TK L+VLLRA V FFSSWG+  L+ QLHD  +VV   A +IL EA ED+A ++ LI    A  H    G +L  R LS+P  F  L  +  V   LD W+K YN  Y
Sbjct:  633 SQHYFLFLGTLSPHPQGVKLLEKCVCIFVICSLLNLCSIKNQDALLKLAVTTLDYSRDGLARVILSKVLTAATDTCRLYATKHLRVLLRAGVEFFSSWGMELLVTQLHDHSKVVSIEALDILDEACEDKANLHALIQLKPAVSHLGDKGLLLLLRFLSIPKGFSYLNERGYVSKQLDKWQKEYNLKY 819

HSP 2 Score: 28.8758 bits (63), Expect = 1.920e-26
Identity = 29/123 (23.58%), Postives = 50/123 (40.65%), Query Frame = 1

Query: 2851 RISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVI----MDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            R SN+   +P ++ L  H YG +   K G  +L  +  + +    I    +D W  ++                     L++S+ A+ +I  S WGL  + E N+   +  L Q     +VRG
Sbjct:  845 RRSNQRLQRP-NVYLPVHLYGQLVHDKTGCHLLEAQNVVPDLSYTIRSPMLDTWEGIKQ--------------------LKASLWALGNIGSSNWGLNLLQEENVIPDILVLAQHCEVLSVRG 946

HSP 3 Score: 116.701 bits (291), Expect = 1.676e-25
Identity = 108/413 (26.15%), Postives = 200/413 (48.43%), Query Frame = 2

Query:   86 ETTKINLNDGPVFNFVKIFTALSDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLXXXXXXXXXXXXLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYT-LQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGY-FNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFE 1318
            E   ++L+  P  NF +I   ++     + +   + +LN  + L   +    +  G  +  I   ++ +L +++K VR A LR LRY + +   ++  L++++D+LI R +D+          + S++ ER  A+RL+ ++  ++  LFP S+ N+L  I   G        D  +R A+ I+C+L +  P+  +K   L T L++VI   D +  R+N    EA++ T L L+ H   R  V       + L PF+      +    E     +    +  F S+ ++I +  F+SWSG++ L    N  I SL GLL +    +R  +L++ +++F +  P  T  DF  +L+S+      + +  W L D F+  +    L H + +R +++DNY A +L  F+   + E
Sbjct:   24 ENVPLDLSREPSENFREILQNVAKPH-GVSNMRKLGHLNNFIKLLCSVGHHEEQFGFTYEEIIICLRLALLNEAKEVRAAGLRALRYLIRDTCVLQKVLRLQVDYLISRCIDI----------QQSNEGERTQALRLVRKIISVNAMLFPTSITNSLIAIGTDGLQER----DRMVRAAIAIVCELALKNPEVVAKRGGLSTILKSVI---DCQLSRIN----EALITTILHLLNHPCTRQYVRTDVELEQILAPFTDFHYRHNADTAEGQIKED---REARFLSSRMAI-VAAFRSWSGIINLCKDENSGIQSLIGLLCIPNMEVRKGLLEVFYEIFRLPIPIAT-QDFAEALQSV---DPARFQDTWRLSDGFVAAEAKVVLLHRARSRPDLMDNYLAFVLSAFISSGLLE 406

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Planmine SMEST
Match: SMESG000033571.1 (SMESG000033571.1)

HSP 1 Score: 1246.88 bits (3225), Expect = 0.000e+0
Identity = 635/636 (99.84%), Postives = 635/636 (99.84%), Query Frame = 2

Query:   20 MSDNLFKNNFVKKYKSIKENCFETTKINLNDGPVFNFVKIFTALSDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLXXXXXXXXXXXXLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPAXXXXXXXXXXYPDFASKNEILYTLQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGYFNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFF 1927
            MSDNLFKNNFVKKYKSIKENCFETTKINLNDGPVFNFVKIFTALSDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLFFISIYSIIKFSLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPALLILCQLLILYPDFASKNEILYTLQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGYFNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKF 
Sbjct:    1 MSDNLFKNNFVKKYKSIKENCFETTKINLNDGPVFNFVKIFTALSDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLFFISIYSIIKFSLWSDSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQYRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVLDIAIRPALLILCQLLILYPDFASKNEILYTLQTVICNQDGKAWRLNFRIIEAVLLTQLKLITHSYWRSTVPIGYFNKTLTPFSILSKIQSEPIFESGYFGNYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCSGIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDEFLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNELISSRAGILLANISYKVSILLPADHPLSSKTNASVLFNNPKSQKALLWIHQVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILDSCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKAFYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFL 636

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Planmine SMEST
Match: SMESG000033570.1 (SMESG000033570.1)

HSP 1 Score: 1006.51 bits (2601), Expect = 0.000e+0
Identity = 553/554 (99.82%), Postives = 553/554 (99.82%), Query Frame = 2

Query: 4358 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKLRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMXXXXXXXXXXXXXXXXXRCXXXXXXXXXXHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKXXXXXXXXXXXXXEPRCCDQMDQSLVGIFSNIRKTXXXXXXXXXXXXXXXFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCL 6019
            TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSK RRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCL
Sbjct:  322 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKHRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCL 875

HSP 2 Score: 365.925 bits (938), Expect = 4.975e-177
Identity = 176/176 (100.00%), Postives = 176/176 (100.00%), Query Frame = 2

Query: 2288 MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 2815
            MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ
Sbjct:    1 MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 176

HSP 3 Score: 278.1 bits (710), Expect = 4.975e-177
Identity = 130/130 (100.00%), Postives = 130/130 (100.00%), Query Frame = 1

Query: 2818 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG
Sbjct:  192 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 321

[Close]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Planmine SMEST
Match: SMESG000033570.1 (SMESG000033570.1)

HSP 1 Score: 1006.13 bits (2600), Expect = 0.000e+0
Identity = 570/571 (99.82%), Postives = 570/571 (99.82%), Query Frame = 2

Query: 4358 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKLRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMXXXXXXXXXXXXXXXXXRCXXXXXXXXXXHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKXXXXXXXXXXXXXEPRCCDQMDQSLVGIFSNIRKTXXXXXXXXXXXXXXXFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCLXXXXXXXXXXXXXXTRL 6070
            TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSK RRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCLEEFSKENKSKSSFSTRL
Sbjct:  322 TGVLCLGLLGSTRKGADVLLNYDWLTLRSDRFDKWPLLLDAFHNVQQNRSKHRRQFQSTNELGNTLKKKSMFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILNMKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRDFSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSVSSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPRSNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGLSLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYECVDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGYHVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIEFRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICILMSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCLEEFSKENKSKSSFSTRL 892

HSP 2 Score: 365.54 bits (937), Expect = 3.202e-177
Identity = 176/176 (100.00%), Postives = 176/176 (100.00%), Query Frame = 2

Query: 2288 MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 2815
            MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ
Sbjct:    1 MSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILGSLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVNFLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHILFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQ 176

HSP 3 Score: 278.87 bits (712), Expect = 3.202e-177
Identity = 130/130 (100.00%), Postives = 130/130 (100.00%), Query Frame = 1

Query: 2818 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 3207
            VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG
Sbjct:  192 VNHNSDDPDENRISNKIKCKPRDLILLCHPYGSISEHKAGMDILYKRGDLQECLVVIMDEWNRLRDGDIQNETHTSFLKVDEHELILRSSMLAICHIARSPWGLEFIIEMNIPLIVSRLTQFHPSFNVRG 321

The following BLAST results are available for this feature:

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Celegans
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Fly
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Mouse
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. UniProt/SwissProt
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Cavefish
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Sea Lamprey
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Yeast
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Nematostella
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Medaka
BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Planmine SMEST

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
RICTOR	3.206e-29	27.40	RPTOR independent companion of MTOR complex 2 [Sou...	[more]
RICTOR	3.256e-29	27.40	RPTOR independent companion of MTOR complex 2 [Sou...	[more]
RICTOR	1.167e-8	29.35	RPTOR independent companion of MTOR complex 2 [Sou...	[more]
RICTOR	5.607e-8	29.94	RPTOR independent companion of MTOR complex 2 [Sou...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
rict-1	1.059e-10	29.46	pep chromosome:WBcel235:II:13098250:13116806:-1 ge...	[more]
rict-1	1.095e-10	29.46	pep chromosome:WBcel235:II:13098249:13116806:-1 ge...	[more]
rict-1	1.707e-8	31.07	pep chromosome:WBcel235:II:13098249:13110236:-1 ge...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
rictor	4.667e-17	27.78	gene:FBgn0031006 transcript:FBtr0343635	[more]
rictor	4.674e-17	27.78	gene:FBgn0031006 transcript:FBtr0074689	[more]
rictor	4.822e-17	27.78	gene:FBgn0031006 transcript:FBtr0343634	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rictorb	2.510e-29	28.80	RPTOR independent companion of MTOR, complex 2b [S...	[more]
rictorb	2.982e-29	28.80	RPTOR independent companion of MTOR, complex 2b [S...	[more]
rictora	1.399e-28	28.53	RPTOR independent companion of MTOR, complex 2 a [...	[more]
rictora	1.534e-28	28.53	RPTOR independent companion of MTOR, complex 2 a [...	[more]
rictorb	1.258e-10	27.71	RPTOR independent companion of MTOR, complex 2b [S...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
smarcc1	1.030e-26	37.97	SWI/SNF related, matrix associated, actin dependen...	[more]
smarcc1	1.109e-26	37.97	SWI/SNF related, matrix associated, actin dependen...	[more]
smarcc1	1.128e-26	37.97	SWI/SNF related, matrix associated, actin dependen...	[more]
smarcc1	1.287e-26	37.97	SWI/SNF related, matrix associated, actin dependen...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Rictor	2.395e-29	27.40	RPTOR independent companion of MTOR, complex 2 [So...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|Q6R327\|RICTR_HUMAN	1.539e-28	27.40	Rapamycin-insensitive companion of mTOR OS=Homo sa...	[more]
sp\|Q6QI06\|RICTR_MOUSE	1.675e-28	27.40	Rapamycin-insensitive companion of mTOR OS=Mus mus...	[more]
sp\|O77203\|PIAA_DICDI	1.605e-12	32.30	Protein pianissimo A OS=Dictyostelium discoideum O...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
H9XVZ8	7.661e-101	88.64	Rictor (Fragment) OS=Schmidtea mediterranea OX=793...	[more]
C3ZJ41	2.450e-60	27.04	Uncharacterized protein OS=Branchiostoma floridae ...	[more]
K1PHU1	3.341e-59	25.17	Rapamycin-insensitive companion of mTOR OS=Crassos...	[more]
A0A210PEL5	2.083e-58	25.43	Rapamycin-insensitive companion of mTOR OS=Mizuhop...	[more]
X2A9R0	1.402e-56	25.70	Uncharacterized protein OS=Capitella teleta OX=283...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
rictorb	8.809e-26	36.96	RPTOR independent companion of MTOR, complex 2b [S...	[more]
rictora	1.660e-25	38.04	RPTOR independent companion of MTOR, complex 2 a [...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO33699	4.631e-28	27.09	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
rictora	1.001e-28	28.53	RPTOR independent companion of MTOR complex 2 [Sou...	[more]
rictora	1.920e-26	39.57	RPTOR independent companion of MTOR complex 2 [Sou...	[more]

BLAST of RPTOR independent companion of MTOR, complex 2 a vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000033571.1	0.000e+0	99.84	SMESG000033571.1	[more]
SMESG000033570.1	4.975e-177	99.82	SMESG000033570.1	[more]
SMESG000033570.1	3.202e-177	99.82	SMESG000033570.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30014131 ID=SMED30014131|Name=RPTOR independent companion of MTOR, complex 2 a|organism=Schmidtea mediterranea sexual|type=transcript|length=6177bp
GAAAAACTTTCAAATTCCAATGTCTGATAATCTATTTAAAAATAATTTTG
TGAAAAAATATAAAAGTATTAAAGAAAACTGCTTTGAAACTACCAAAATC
AATTTAAATGATGGCCCAGTATTTAACTTTGTAAAAATATTTACTGCCCT
ATCTGACAATAAAGTTCCGTTAAAATCGGAAAATCATGTGGCTTATTTAA
ATATATTAGTATATTTAAGTAAGGATTTGTTACAAGAATATGACAACAAA
GGCCTTTTTTTTATATCAATATATTCAATAATCAAATTTAGTCTTTGGAG
TGATTCTAAATTGGTAAGAACAGCAGCATTAAGATGTCTCAGATACTATG
TACTCAACGTCTATCATGTGGAATTATTTTTAAAGATGAGATTAGACTTT
TTAATTATGAGGAGTTTAGATTTATCATATGAAAATGCAATTAATAACCA
ATACCGTAATAGCGATGACGCTGAACGGATTCATGCAATGAGATTGTTGT
ATAGGTTGAGTTTAATTTCGCCAAAACTTTTCCCTTTCAGCTTGATCAAC
GCGCTCACTGTTATTTGCTTATCAGGTTCCGATTCCAGCGGAAATGTTCT
CGACATTGCTATTCGACCGGCCCTGTTGATACTGTGCCAGTTATTAATCC
TCTATCCAGATTTTGCTTCAAAAAATGAAATTTTATATACCCTTCAAACA
GTAATTTGTAATCAAGATGGAAAAGCGTGGCGTCTCAATTTTCGAATTAT
CGAAGCAGTATTACTGACCCAATTAAAACTCATAACCCATTCATATTGGA
GAAGCACAGTACCCATAGGATACTTCAATAAAACATTGACACCATTTTCA
ATCTTATCGAAAATTCAATCAGAACCAATATTTGAATCGGGATATTTTGG
AAATTATGTAAGTACTCAGCATGAATTTGAAAGCACTTCTATTTCAATTC
TGTTAACTCTTTTCCAATCGTGGTCAGGTTTACTGTATTTATTTGGTTCA
AATAACAAGCCTATTCTAAGTTTGACTGGCCTGTTGGCTGTTGGGTGTAG
TGGTATTCGAGGAAGAATACTGGATTTACTGTTCCAGTTATTCAATATCT
ACAGACCTCCAAACACTTGCACTGATTTTGTGAGCTCTCTCGAATCCATC
ACTGAACAGAGCACTGGAAAAAATAGACCAGTTTGGAATTTGGATGATGA
ATTTCTAGTTGGTCAATGTAATGATTGCCTACCTCATTTATCAGGGAATC
GGATTAATGTCATAGATAATTACCAGGCTATATTGTTAGGGATTTTTGTG
CAATGCAATATATTTGAGGCCTTAGAGAGTGCTGTTGCTGATGACAACGA
GTTAATCTCGTCTCGCGCTGGAATATTATTGGCTAATATTTCTTATAAGG
TGTCAATTTTATTGCCGGCTGATCATCCTTTGAGTAGCAAAACCAATGCA
AGCGTTTTATTCAACAATCCAAAATCTCAAAAGGCTTTATTATGGATACA
TCAAGTTCATCAATTACTCGAACATCATCAATTTGAGATAACACCATTTT
TAACTTATATTATTCAGCAGCACCCCACAATTAATGTTAATGATTATGGA
GTTCAATCAAAAAGGTTTCTGCAGCCAGCCAATATTGATGAGATTCTAGA
TAGTTGTTATTTACCTTACTTAGGATCGGCTAATAAACCATCTCAGCCTT
CATTATCTCAGCAAACCTCAAATAAAAATTACAGAGTTGGAGCACTATTA
GATCAAATTGTTCGTTACAGCAATATTTTTGAGTCTATAAATGAGAAAGC
ATTTTATGATTCATGGGATTGGGATTTACTAATGGTATTCGGTCGGTCAT
TAGTTGATTCCAAACCAACTTTAAACATTGATAAAGAATCACTTTCTAGA
GTGATTCAAGTTTTAATGAAATTTTTTACATTAAAAGCAACGGCAGCTAA
TTCATCCTATAGTGGCAAAAATCTGTCCATTGCCAAATTTGCATTATTGC
CACTGACATGGAAACATTCTACAAATGCTGCATTTGTTATTACAGATATT
ATATGCTATTTAGTCGAAAGTTCCAAGGAATCTGAAATCAGCGAAGAACT
GAATGAATTTTTAATTGGTATGTATTCCAATCTGAAAGATTGTCTTCTAT
CTATTGCCGATGAAAAGTATATACAAGAAATAAAAGATAATTTTGGTTTC
AATAAGACTTATGAGGCGTGTGGAATATTCACTGAATATGATCTAAATTA
CAAATGCAGCTCATATTTGATTCTCGCCATTGGAAGGATGAGTGTTTCGG
ATATCGGAGAAACTATACTTGAGAAAATTGGTTTTGTGAATTTATTTAAA
GCGTTTTTGGATTATTCAAGAAGTGATGCATTAACGAAATTAATTCTCGG
AAGTTTGGATTACACTAGACCTTCGCTAGGCAGAAGCCTTCTATCAATTG
CTATTAGATCGGATAATTTGTGGACCAGGCGTTATTCAACAAAATTTCTC
AAAGTTTTACTTAGAGCTAAAGTTCCATTTTTCTCCAGTTGGGGAGTTAA
TTTTCTTATGAAACAATTACACGATTGCGATCGTGTTGTAAAACAAGCAG
CATATGAAATTCTTATGGAAGCCAGTGAGGATGAAGCGGTTGTAAATAAT
CTAATAATTGAATCTATTGCTACATTGCATCAAGATTTTTTTGGGCATAT
ACTATTTTCTCGATTGCTATCACTTCCTTCTCATTTTGATAAATTACAAA
ATAAAAACGGAGTGTATTTCTTTTTAGACAATTGGAAAAAAAATTATAAC
ACATTATATTGCCAAAAGTTAATCATAACTCTGATGATCCTGACGAAAAT
AGAATATCTAATAAAATTAAATGCAAACCGAGAGACCTGATACTTCTTTG
TCATCCTTATGGTTCGATATCGGAACATAAAGCAGGCATGGATATACTTT
ATAAAAGGGGTGATCTTCAAGAATGTTTGGTTGTTATTATGGATGAGTGG
AATAGATTACGTGATGGTGATATTCAAAATGAAACTCATACGAGTTTTCT
CAAAGTTGATGAGCACGAACTTATTTTACGTTCAAGTATGCTGGCAATAT
GTCACATAGCTCGAAGTCCATGGGGTCTAGAGTTCATAATCGAAATGAAT
ATACCTTTGATAGTTTCAAGGTTGACACAGTTTCACCCTAGTTTTAATGT
CAGAGGGTAATTTTTACATTGAACTATTTATAATCTTTATAACATCATGT
TTCTTTAAAATATTATAAATAAATGACACTCAAAACTAACTTCATGTTTA
TAATTTCAAGTAAATGTGCTATCATTATAACTTCTAAATACTCGAAAACT
ATTTCAAGTTTCACTGGATTTGAACCACTGGACGTTGGAATTGGTTACTC
CCATTATTCCATTCAAAATTTTAAACCTTCGCCATTGAAAATGTAATAGT
GGATTTATGTTTTCTTTTGGACATTATCAGTTTTCTATTATAAATATTGG
CAGTTTTTGACCTTCAATTGCAATGGGTTTTCATAGATCGATTGTTTAAG
TTGTAACAGCTCTTTATTTTATATCATTTTCATGTAATTGGTATAAATGT
TCAATAATTTTCTTTGTTAATATATTTCGTTGACATCATTCTAGGAGAAA
TAAATAAAATAAGAACAAAATTGAGATCGAGAATTAGTTTTTTCAAATGG
AGAAATAAAGGTACGAAATATGAAAATATGGCGAGTCTTTAAATAATAAC
TAAATCATCTGTCTAAAATATCATGGAACATGGCCAAAACCAAAACTAAT
AACATTTCATCAAGTTAAAGAAGTGTATTCCAATGATAGAAGGTGTATAT
GCAAACGAATTGACTGCTGGTTGTTATTTGATTTGTGAAGAGGAATGCCA
TGATTGTGGAACCTATGTTGTAGAAACAGCAGTACCCTGCAGAATGAAAA
GACAGTGTCAACCTGTGAAAAGGTATGGTTTGGTTAATCGATTCAAACAA
AATAAATATATTAAAATCACCAGTAAACAACCCGGAAAATGTTATCAAAC
TTAATATATATCAACTCACCAATTAAAAATAGTGATAATAACTCTTTGAC
AAGATAGTTCCGAAAATTCGTGTTAGGTAGAATTTAAAGATAAATTAAAC
TCTAAAAGAAAAAATAAAATCAGATCAAAAGTGAATAAAGATATCAATGA
TCTTACGGATGTCATCATTTTTATTTCCTTATTCTTAACGCTCTGTTAGA
ATTGATTCCTGCAGTTTCAAAACCAATTATTATGTAGCTTAAACACAGCA
GATTCCTCATTGCTGATGCAGACTGATAAAAAAATAAATTGAAAATATGT
GTTTAGAACTGGAGTTTTGTGCTTGGGTCTTCTGGGGTCTACTCGAAAAG
GTGCCGATGTTCTATTAAATTACGATTGGCTTACTCTAAGAAGTGACAGA
TTTGACAAGTGGCCGTTGTTGTTAGATGCCTTTCACAATGTCCAGCAGAA
TCGGTCTAAACTTAGACGTCAATTTCAATCTACAAATGAACTGGGAAACA
CATTAAAAAAGAAGTCCATGTTTTTAGATGAATTCGACAAAGTAAATATT
AATTCAGAACAAAGTTCTGCAGTCGGTTATTCTGTATTTGCTGCTCCGTT
AGCATCAGACGAGCCTATAAAGAAAACTAGTTTCGCATTAATTGATGATC
CAACCTTTATATTAAATATGAAGAAATTCAAGATTTATTCTAAATCTATT
GATGACTCGATAATAAAATCACGGTGTACGACAGTCACCAGTAGCTCCTC
CAGTACACACATTTCAGATGGAGATCATCAACAAAAGTTGAACAAATTTA
TTCACCACAAAAGGGATTTTTCTGGAGGTTCCGCAAGCTTATTTAATGTT
AATACAGAAGAAACATCTGAAGCGTTTACACCTCACGATGTACTTGGAAT
AGCTACGATGAGAAAATTACAAACAAAATTTCGAAATGATTTATCCCAGA
AGAACACTTCTAGTGTTTCTAGTTATTATAACAATTACAATGAACCACGC
TGTTGTGATCAAATGGATCAGAGTTTGGTTGGAATTTTTTCCAATATTAG
GAAAACATCAAGTTGTGTGGATAAGAAAAGCCGAAAAAAGAAGTTCTCCA
GTTTCATTAATCCCAGGAGTAATCTAAATAGATATCGTGGATTGGTTCTA
CCAATTAATTTTAATGATTTAATAATGAACATTTTTAAAACACCTGAAGA
AAGAAACGCTGAACGAAGCAGCTATGAAAAAGTTCAAATGTGGGAAGTTT
CTAACGAAACAGGTTTAAGTCTGGAAAATTCAATAAAGGAAAGTAGTGTG
TTGGAAGGAAAAGAATCAGTATCACTGCAAAAATCTAGATCTATTACCTT
TGAAGAGTCGTCTTGTGTATTAGATATCGCCTTGCTTGGAAATGAATCTA
CTCTTCATTACGAATGTGTCGATAAAATTAAACCGACTCGATCTAGTAGT
GATGAACAAAATTGGGCTGGTAAAGAAATCATATTTATCCGACCTCGAGC
AATTACAGATATAAAGGAATTTGAAAAATTACCAAAGGACAATAGACATT
CAGGATCCATTGGGTATCATGTCACTCATTTCCGTGACGCATTCCTTTTC
ATTGGTGATAAACTACCAAAGCGAATTGAACAACGGAATGGTTTAAGCTA
TCACAGTCAGGATCATTGTGTGCATGTTTACTGTCAGTCTGAACAAGTCA
GTGAAGAAGTTATTGAATTTCGCCAAAAGATTCTGAAATCAGTGAGTCTC
ATGCTTACAATTAGCTCGAAAACAAAAAAAACTGAAATGAATCTTGCAAG
ATTAAAAAGTGGGCAAAATCAATTATTTTGGATAGATCCTTGCTTGTTCT
CTGAAATTTGTATACTTATGAGTTTGTATAGCTTTTCCAGGCTATCTAGA
CAATATATTCAAGAATTATTTCTTTCAGTTCCAATGAACCAACTTCAAGA
TGATATGAAATTATGTTTGGAGGAATTTTCCAAAGAAAATAAGAGTAAAT
CTTCATTCTCTACCAGACTCTAATCTATAACAATTGTTTTGTCACAATAT
TCGTCTTCATGTATAAAATATTGTAGTAACAACGAATGGAGATATTCTTT
GTTTTTTAACACGTGATGATTATTTAC

protein sequence of SMED30014131-orf-1

>SMED30014131-orf-1 ID=SMED30014131-orf-1|Name=SMED30014131-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=963bp
KNFQIPMSDNLFKNNFVKKYKSIKENCFETTKINLNDGPVFNFVKIFTAL
SDNKVPLKSENHVAYLNILVYLSKDLLQEYDNKGLFFISIYSIIKFSLWS
DSKLVRTAALRCLRYYVLNVYHVELFLKMRLDFLIMRSLDLSYENAINNQ
YRNSDDAERIHAMRLLYRLSLISPKLFPFSLINALTVICLSGSDSSGNVL
DIAIRPALLILCQLLILYPDFASKNEILYTLQTVICNQDGKAWRLNFRII
EAVLLTQLKLITHSYWRSTVPIGYFNKTLTPFSILSKIQSEPIFESGYFG
NYVSTQHEFESTSISILLTLFQSWSGLLYLFGSNNKPILSLTGLLAVGCS
GIRGRILDLLFQLFNIYRPPNTCTDFVSSLESITEQSTGKNRPVWNLDDE
FLVGQCNDCLPHLSGNRINVIDNYQAILLGIFVQCNIFEALESAVADDNE
LISSRAGILLANISYKVSILLPADHPLSSKTNASVLFNNPKSQKALLWIH
QVHQLLEHHQFEITPFLTYIIQQHPTINVNDYGVQSKRFLQPANIDEILD
SCYLPYLGSANKPSQPSLSQQTSNKNYRVGALLDQIVRYSNIFESINEKA
FYDSWDWDLLMVFGRSLVDSKPTLNIDKESLSRVIQVLMKFFTLKATAAN
SSYSGKNLSIAKFALLPLTWKHSTNAAFVITDIICYLVESSKESEISEEL
NEFLIGMYSNLKDCLLSIADEKYIQEIKDNFGFNKTYEACGIFTEYDLNY
KCSSYLILAIGRMSVSDIGETILEKIGFVNLFKAFLDYSRSDALTKLILG
SLDYTRPSLGRSLLSIAIRSDNLWTRRYSTKFLKVLLRAKVPFFSSWGVN
FLMKQLHDCDRVVKQAAYEILMEASEDEAVVNNLIIESIATLHQDFFGHI
LFSRLLSLPSHFDKLQNKNGVYFFLDNWKKNYNTLYCQKLIITLMILTKI
EYLIKLNANRET*

protein sequence of SMED30014131-orf-2

>SMED30014131-orf-2 ID=SMED30014131-orf-2|Name=SMED30014131-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=502bp
MFLDEFDKVNINSEQSSAVGYSVFAAPLASDEPIKKTSFALIDDPTFILN
MKKFKIYSKSIDDSIIKSRCTTVTSSSSSTHISDGDHQQKLNKFIHHKRD
FSGGSASLFNVNTEETSEAFTPHDVLGIATMRKLQTKFRNDLSQKNTSSV
SSYYNNYNEPRCCDQMDQSLVGIFSNIRKTSSCVDKKSRKKKFSSFINPR
SNLNRYRGLVLPINFNDLIMNIFKTPEERNAERSSYEKVQMWEVSNETGL
SLENSIKESSVLEGKESVSLQKSRSITFEESSCVLDIALLGNESTLHYEC
VDKIKPTRSSSDEQNWAGKEIIFIRPRAITDIKEFEKLPKDNRHSGSIGY
HVTHFRDAFLFIGDKLPKRIEQRNGLSYHSQDHCVHVYCQSEQVSEEVIE
FRQKILKSVSLMLTISSKTKKTEMNLARLKSGQNQLFWIDPCLFSEICIL
MSLYSFSRLSRQYIQELFLSVPMNQLQDDMKLCLEEFSKENKSKSSFSTR
L*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000026	gut
PLANA:0000044	cephalic ganglia
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000136	whole organism
PLANA:0000418	head
PLANA:0000429	neoblast
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR028267	Pianissimo_N
IPR029451	RICTOR_M
IPR029453	Rictor_IV
IPR016024	ARM-type_fold

Vocabulary: **molecular function**
Term	Definition
GO:0005488	binding

Vocabulary: **biological process**
Term	Definition
GO:0031929	TOR signaling

Vocabulary: **cellular component**
Term	Definition
GO:0031932	TORC2 complex

Main menu

RPTOR independent companion of MTOR, complex 2 a

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Owlery

blazegraph-runner