Fumarate hydratase

Overview
NameFumarate hydratase
Smed IDSMED30014122
Length (bp)1861
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Fumarate hydratase (SMED30014122) t-SNE clustered cells

Violin plots show distribution of expression levels for Fumarate hydratase (SMED30014122) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Fumarate hydratase (SMED30014122) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Fumarate hydratase (SMED30014122) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30014122

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30014122SMESG000048275.1 dd_Smed_v4_741_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30014122SMESG000048275.1 dd_Smed_v4_741_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30014122SMESG000048275.1 dd_Smed_v4_741_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30014122SMESG000048275.1 dd_Smed_v4_741_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014122SMESG000048275.1 Contig44373newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014122SMESG000048275.1 Contig44373uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014122SMESG000048275.1 SMESG000038294.1 SMESG000032747.1 Contig12966newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014122SMESG000048275.1 SMESG000038294.1 SMESG000032747.1 Contig12966uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Fumarate hydratase vs. Ensembl Human
Match: FH (fumarate hydratase [Source:HGNC Symbol;Acc:HGNC:3700])

HSP 1 Score: 488.034 bits (1255), Expect = 3.985e-167
Identity = 253/475 (53.26%), Postives = 326/475 (68.63%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FRIE D+ GE+KVP   YYG+QT RS  NF++   T++MP  VIK+  +LK +AAE N   G L  K   +I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  + +   L+P L+ L   + AK  EFA++IKIGRTH QDAVPLT+GQE S YV Q+ Y++ +I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F + CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   46 SQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYG-LDPKIANAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 510
[Close]
BLAST of Fumarate hydratase vs. Ensembl Human
Match: AMACR (alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451])

HSP 1 Score: 80.8777 bits (198), Expect = 3.448e-16
Identity = 33/62 (53.23%), Postives = 49/62 (79.03%), Query Frame = 3 
Query:  990 LPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHS 1175
            L EN  GSSI+PGK NP QCE++++V AQVMG  VA+++G   GH EL+V+KP++I+N+ ++
Sbjct:  199 LAENTTGSSIVPGKANPRQCEAMAIVAAQVMGFCVAVTVGGGNGHFELDVFKPMMIKNLCYT 260
[Close]
BLAST of Fumarate hydratase vs. Ensembl Celegans
Match: fum-1 (Probable fumarate hydratase, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O17214])

HSP 1 Score: 481.485 bits (1238), Expect = 3.994e-165
Identity = 251/473 (53.07%), Postives = 323/473 (68.29%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLN--VNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
             R E+D+ GE++VP   YYG+QT RS+ NF++    ++MP  VI +  +LK +AA  N + G L  K   +I  A D  +       +HFPLV WQTGSGTQSNMNVNEV+SN A + LG ELGSK P+HPNDHVNMSQSSNDTFPTAM+IA    + ++L+PALK LR  +  K  EF  +IKIGRTH QDAVPLT+GQE S+YV QLD S+ ++  T+  + +             GT  G  +   K   + V   ++    + F  A NKF ALAAHD+L+ V G LNT+A + MKI ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN VA+S+G S GH ELNV+KPLI+RNVL S ++LADS+  F  +CV+G+  N   I   + +SLMLVTAL+P IGYD +A+IAK +HKN  +L + A+KL +++EE F +W+ P  ML PK
Sbjct:   41 IRKERDTFGELEVPADKYYGAQTARSQMNFKIGGPEERMPIPVIHAFGILKKAAALVNTEFG-LDKKLADAISQAADEVVD--GKLDEHFPLVTWQTGSGTQSNMNVNEVISNRAIEILGGELGSKKPVHPNDHVNMSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQ---------LAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 501
[Close]
BLAST of Fumarate hydratase vs. Ensembl Celegans
Match: fum-1 (Probable fumarate hydratase, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O17214])

HSP 1 Score: 359.377 bits (921), Expect = 5.625e-120
Identity = 181/337 (53.71%), Postives = 233/337 (69.14%), Query Frame = 3 
Query:  444 MSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLN--VNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            MSQSSNDTFPTAM+IA    + ++L+PALK LR  +  K  EF  +IKIGRTH QDAVPLT+GQE S+YV QLD S+ ++  T+  + +             GT  G  +   K   + V   ++    + F  A NKF ALAAHD+L+ V G LNT+A + MKI ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN VA+S+G S GH ELNV+KPLI+RNVL S ++LADS+  F  +CV+G+  N   I   + +SLMLVTAL+P IGYD +A+IAK +HKN  +L + A+KL +++EE F +W+ P  ML PK
Sbjct:    1 MSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQ---------LAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 328
[Close]
BLAST of Fumarate hydratase vs. Ensembl Celegans
Match: fum-1 (Probable fumarate hydratase, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O17214])

HSP 1 Score: 359.377 bits (921), Expect = 5.625e-120
Identity = 181/337 (53.71%), Postives = 233/337 (69.14%), Query Frame = 3 
Query:  444 MSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLN--VNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            MSQSSNDTFPTAM+IA    + ++L+PALK LR  +  K  EF  +IKIGRTH QDAVPLT+GQE S+YV QLD S+ ++  T+  + +             GT  G  +   K   + V   ++    + F  A NKF ALAAHD+L+ V G LNT+A + MKI ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN VA+S+G S GH ELNV+KPLI+RNVL S ++LADS+  F  +CV+G+  N   I   + +SLMLVTAL+P IGYD +A+IAK +HKN  +L + A+KL +++EE F +W+ P  ML PK
Sbjct:    1 MSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQ---------LAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 328
[Close]
BLAST of Fumarate hydratase vs. Ensembl Celegans
Match: fum-1 (Probable fumarate hydratase, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O17214])

HSP 1 Score: 359.377 bits (921), Expect = 5.625e-120
Identity = 181/337 (53.71%), Postives = 233/337 (69.14%), Query Frame = 3 
Query:  444 MSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLN--VNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            MSQSSNDTFPTAM+IA    + ++L+PALK LR  +  K  EF  +IKIGRTH QDAVPLT+GQE S+YV QLD S+ ++  T+  + +             GT  G  +   K   + V   ++    + F  A NKF ALAAHD+L+ V G LNT+A + MKI ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN VA+S+G S GH ELNV+KPLI+RNVL S ++LADS+  F  +CV+G+  N   I   + +SLMLVTAL+P IGYD +A+IAK +HKN  +L + A+KL +++EE F +W+ P  ML PK
Sbjct:    1 MSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQ---------LAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 328
[Close]
BLAST of Fumarate hydratase vs. Ensembl Celegans
Match: fum-1 (Probable fumarate hydratase, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O17214])

HSP 1 Score: 359.377 bits (921), Expect = 5.625e-120
Identity = 181/337 (53.71%), Postives = 233/337 (69.14%), Query Frame = 3 
Query:  444 MSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLN--VNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            MSQSSNDTFPTAM+IA    + ++L+PALK LR  +  K  EF  +IKIGRTH QDAVPLT+GQE S+YV QLD S+ ++  T+  + +             GT  G  +   K   + V   ++    + F  A NKF ALAAHD+L+ V G LNT+A + MKI ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN VA+S+G S GH ELNV+KPLI+RNVL S ++LADS+  F  +CV+G+  N   I   + +SLMLVTAL+P IGYD +A+IAK +HKN  +L + A+KL +++EE F +W+ P  ML PK
Sbjct:    1 MSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLTLGQEFSAYVTQLDNSIARVESTLPRLYQ---------LAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGIVANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKPENMLGPK 328
[Close]
BLAST of Fumarate hydratase vs. Ensembl Fly
Match: Fum1 (gene:FBgn0286222 transcript:FBtr0070954)

HSP 1 Score: 484.182 bits (1245), Expect = 1.629e-166
Identity = 262/475 (55.16%), Postives = 340/475 (71.58%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +S+ FR+E D+ GE+KVP   YYG+QT RS+ NF +   T++MP+ V++++ +LK +AAE N + G L +K   +I  A D  +S    +  HFPLV+WQTGSGTQSNMNVNEV+SN A + LG +LGSK P+HPNDHVN SQSSNDTFPTA++I+  + L N L PA+K L   + AK  EF  +IKIGRTH  DAVPLT+GQE S Y  QL Y+ ++I   +  V + LA+GGTAVGTGL T  GF  +   ++ +        ++ F  A NKF ALAA D+++ V G LNT+A +LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCESL+M+ AQVMGN VA++IG S GH ELNV+KPLI+ NVL SI++L+D S+ F   CV G+  N   I   +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A+ L  ++E+ F+ W+ P +ML PK
Sbjct:    2 ASQEFRVESDTFGELKVPADKYYGAQTMRSQINFPIGGATERMPKPVVQAMGILKKAAAEVNKEFG-LDSKVSEAISKAADDVISG-KLYDDHFPLVIWQTGSGTQSNMNVNEVISNRAIELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPAIKTLHDALRAKSEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYE-LALGGTAVGTGLNTRKGFAEKCAAKIAELT------SLPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAKIAKTAHKNGTTLKEEAINLGYLTEQQFNDWVRPEQMLGPK 467
[Close]
BLAST of Fumarate hydratase vs. Ensembl Fly
Match: Fum1 (gene:FBgn0286222 transcript:FBtr0070953)

HSP 1 Score: 484.182 bits (1245), Expect = 3.331e-166
Identity = 262/475 (55.16%), Postives = 340/475 (71.58%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +S+ FR+E D+ GE+KVP   YYG+QT RS+ NF +   T++MP+ V++++ +LK +AAE N + G L +K   +I  A D  +S    +  HFPLV+WQTGSGTQSNMNVNEV+SN A + LG +LGSK P+HPNDHVN SQSSNDTFPTA++I+  + L N L PA+K L   + AK  EF  +IKIGRTH  DAVPLT+GQE S Y  QL Y+ ++I   +  V + LA+GGTAVGTGL T  GF  +   ++ +        ++ F  A NKF ALAA D+++ V G LNT+A +LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCESL+M+ AQVMGN VA++IG S GH ELNV+KPLI+ NVL SI++L+D S+ F   CV G+  N   I   +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A+ L  ++E+ F+ W+ P +ML PK
Sbjct:   30 ASQEFRVESDTFGELKVPADKYYGAQTMRSQINFPIGGATERMPKPVVQAMGILKKAAAEVNKEFG-LDSKVSEAISKAADDVISG-KLYDDHFPLVIWQTGSGTQSNMNVNEVISNRAIELLGGKLGSKTPVHPNDHVNKSQSSNDTFPTAIHISVALELNNNLKPAIKTLHDALRAKSEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYE-LALGGTAVGTGLNTRKGFAEKCAAKIAELT------SLPFVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTALNPHIGYDKAAKIAKTAHKNGTTLKEEAINLGYLTEQQFNDWVRPEQMLGPK 495
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BLAST of Fumarate hydratase vs. Ensembl Fly
Match: Fum2 (gene:FBgn0029890 transcript:FBtr0070955)

HSP 1 Score: 482.256 bits (1240), Expect = 3.050e-165
Identity = 266/471 (56.48%), Postives = 338/471 (71.76%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            FR EKD+ GE+KVP    YG+QT RSK NF +    ++MP  VI+++ +LK + AE N   G L  K   ++  A D  +S     + HFPLV+WQTGSGTQ+NMN NEV+SN A K +G ELGSK P+HPNDHVN SQSSNDTFPTA++I+  + L  +L+PA+  LR  + +K  EF  +IKIGRTH+ DAVPLT+GQE S Y  QL   L++I   +  V + LA+GGTAVGTGL T  GF  +V KR+ +         + F  A NKF ALAA D+++ V G LNT+A +LMKIAND RLLGSGPRCG+GE +LPENEPGSSIMPGKVNPTQCES++M+CAQVMGN VA++IG S GH ELNV+KPL++ NVL SI++LAD S  F K CVEGL  N  +I+  +N+SLMLVTAL+P IGYDK+A IAK +HKN  +LKE ALK   ++EE F +W++P +ML PK
Sbjct:   42 FRTEKDTFGELKVPADKLYGAQTMRSKLNFPIGDIGERMPMPVIQAMGILKKACAEVNKDYG-LDGKVSDAVSCACDDVISGKLYKQGHFPLVIWQTGSGTQTNMNTNEVISNAAIKMMGGELGSKKPVHPNDHVNKSQSSNDTFPTAIHISVGMELNERLVPAVTHLRDALKSKSDEFKDIIKIGRTHLMDAVPLTLGQEFSGYTQQLTNGLERIKGCLPRVYE-LALGGTAVGTGLNTRKGFAEKVAKRISELT------CLPFVSAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKVNPTQCESMTMLCAQVMGNQVAVTIGGSNGHFELNVFKPLVVSNVLRSIRLLADGSMTFSKNCVEGLQANKERIDKIMNESLMLVTALNPHIGYDKAALIAKTAHKNKTTLKEEALKTG-ITEEQFKEWVNPKEMLGPK 503
[Close]
BLAST of Fumarate hydratase vs. Ensembl Fly
Match: Fum3 (gene:FBgn0036162 transcript:FBtr0076177)

HSP 1 Score: 448.743 bits (1153), Expect = 1.162e-152
Identity = 251/469 (53.52%), Postives = 323/469 (68.87%), Query Frame = 3 
Query:   39 RIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSP 1445
            R E D++G ++VP+  YYG+QT R   NF +  + ++MP  +I+++ +LK +AAE N + G L  K   +I  A D  +S     + HFPL +WQTGSGTQSNMN NEV+ N A + LG  +G+K+P+HPNDHVN SQSSNDTFP+A++IA   ALT  L PA+  LR  + AK  E+  +IKIGRTH QDAVPLT+GQE S Y  QL   L +I   +  V + LA+GGTAVGTGL T  GF  +  KR+           + F  A N F ALA  D+++ V G LN LA +LMK+ ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++M+CAQVMGN+VA+S+G + GH ELNV+KPLI  NVL SI++LAD    F   CV+G+  N  ++   VN+SLMLVTAL+P IGYDKSAQIAK +HKN  +LK  AL    +SE+DF++W+ P KML P
Sbjct:   10 RQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFG-LDPKLSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVHPNDHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVPLTLGQEFSGYAQQLTNGLQRIDAVLPRVYQ-LALGGTAVGTGLNTRRGFAEKCVKRIAQLS------GLPFVVAPNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVNPTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGIKPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRPEKMLGP 469
[Close]
BLAST of Fumarate hydratase vs. Ensembl Fly
Match: Fum3 (gene:FBgn0036162 transcript:FBtr0331828)

HSP 1 Score: 448.743 bits (1153), Expect = 1.162e-152
Identity = 251/469 (53.52%), Postives = 323/469 (68.87%), Query Frame = 3 
Query:   39 RIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSP 1445
            R E D++G ++VP+  YYG+QT R   NF +  + ++MP  +I+++ +LK +AAE N + G L  K   +I  A D  +S     + HFPL +WQTGSGTQSNMN NEV+ N A + LG  +G+K+P+HPNDHVN SQSSNDTFP+A++IA   ALT  L PA+  LR  + AK  E+  +IKIGRTH QDAVPLT+GQE S Y  QL   L +I   +  V + LA+GGTAVGTGL T  GF  +  KR+           + F  A N F ALA  D+++ V G LN LA +LMK+ ND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++M+CAQVMGN+VA+S+G + GH ELNV+KPLI  NVL SI++LAD    F   CV+G+  N  ++   VN+SLMLVTAL+P IGYDKSAQIAK +HKN  +LK  AL    +SE+DF++W+ P KML P
Sbjct:   10 RQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFG-LDPKLSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVHPNDHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVPLTLGQEFSGYAQQLTNGLQRIDAVLPRVYQ-LALGGTAVGTGLNTRRGFAEKCVKRIAQLS------GLPFVVAPNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVNPTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGIKPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRPEKMLGP 469
[Close]
BLAST of Fumarate hydratase vs. Ensembl Zebrafish
Match: fh (fumarate hydratase [Source:NCBI gene;Acc:393938])

HSP 1 Score: 485.723 bits (1249), Expect = 1.768e-166
Identity = 253/475 (53.26%), Postives = 335/475 (70.53%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            SS+ FRIE+D+ GE+KVP   YYG+QT RS  NF +   T++MP  VI++  +LK +AAE N   G L  K   +I+ A D   S       HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA    +   L+P L+ L   ++AK  +F  +IKIGRTH QDAVPL++GQE   YV Q+ YS+ ++  ++  V +       A GT +GT     +   +++ D V       + F  A NKF ALAAHD+L+ ++G LNT+A ++MKIAND R LGSGPR G+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP+II+NVL+S ++L D+S  F   CV G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK+  +LKEAALKL  ++E+ F++W+ P  ML PK
Sbjct:   45 SSEAFRIERDTFGELKVPSDKYYGAQTVRSTMNFRIGGVTERMPIQVIRAFGILKKAAAEVNKDYG-LDPKIADAIMKAADEVES--GKLDDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAAKEVHEVLLPGLQTLHDALAAKAEQFKDIIKIGRTHTQDAVPLSLGQEFGGYVQQVKYSIARVKASLPRVYE-----LAAGGTAVGTGLNTRIGFAEKVADKVSAL--TGLPFVTAANKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELNLPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMIIKNVLNSARLLGDASVSFTNNCVVGIEANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKDGSTLKEAALKLGFLNEQQFEEWVRPHDMLGPK 509
[Close]
BLAST of Fumarate hydratase vs. Ensembl Zebrafish
Match: CABZ01084963.1 (fumarate hydratase, mitochondrial-like [Source:NCBI gene;Acc:100535417])

HSP 1 Score: 292.738 bits (748), Expect = 8.885e-94
Identity = 146/287 (50.87%), Postives = 197/287 (68.64%), Query Frame = 3 
Query:  450 QSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIG 1310
            QSSNDTFPTAM+IA    +   L+P L+ L   ++AK  +F  +IKIGRTH QDAVPL++GQE   YV Q+ YS+ ++  ++  V +  A G               +   +++ D V       + F  A NKF ALAAHD+L+ ++G LNT+A ++MKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+V +++G S GH ELNV+KP+II+NVL+S ++L D+S  F   CV G+  N  +IN  +++SLMLVTAL+P IG
Sbjct:    7 QSSNDTFPTAMHIAAAKEVHEVLLPGLQTLHDALAAKAEQFKDIIKIGRTHTQDAVPLSLGQEFGGYVQQVKYSIARVKASLPRVYELAAGGTAVGTGLNTR-----IGFAEKVADKVSAL--TGLPFVTAANKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVGVTVGGSNGHFELNVFKPMIIKNVLNSARLLGDASVSFTNNCVVGIEANTERINKLMSESLMLVTALNPHIG 286
[Close]
BLAST of Fumarate hydratase vs. Ensembl Xenopus
Match: tpgs2 (tubulin polyglutamylase complex subunit 2 [Source:Xenbase;Acc:XB-GENE-5836444])

HSP 1 Score: 477.248 bits (1227), Expect = 4.313e-163
Identity = 259/479 (54.07%), Postives = 337/479 (70.35%), Query Frame = 3 
Query:   12 ENGKSSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            + G+ +  +RIE D+ GE++VP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N   G   N     I AA +      +    HFPLVVWQTGSGTQ+NMNVNEV+SN A + +G +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA V  +   L+P L+ L   +  K  EF  +IKIGRTH QDAVPLT+GQE   YV Q+ YS+ +I   +  V + LA GGTAVGTGL T  GF  +V  ++ +         + F  A NKF +LAAHD+L+ ++G LNTLA +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VAISIG S GH ELNV+KP+II+NVL SI++L D++  F   C+ G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE A+KL  ++ + FD+W+ P  ML PK
Sbjct:   29 KQGRMASSYRIESDTFGELQVPNDKYYGAQTVRSTMNFKIGGVTERMPVPVIRAFGILKRAAAEVNQDYGLDPNIANFIIKAADEVSSGKLD---DHFPLVVWQTGSGTQTNMNVNEVISNRAIEMMGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAVKEVHEVLLPGLQKLHDALEEKSKEFENIIKIGRTHTQDAVPLTLGQEFGGYVQQIKYSVSRIKAALPRVYE-LAAGGTAVGTGLNTRIGFAEKVAAKVAELT------GLPFITAPNKFESLAAHDALVELSGALNTLACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAVTMVAAQVMGNHVAISIGCSNGHFELNVFKPVIIKNVLQSIRLLGDAAVSFTDNCIVGVQANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKETAIKLGFLTSDQFDQWVKPEDMLGPK 497
[Close]
BLAST of Fumarate hydratase vs. Ensembl Xenopus
Match: tpgs2 (tubulin polyglutamylase complex subunit 2 [Source:Xenbase;Acc:XB-GENE-5836444])

HSP 1 Score: 474.937 bits (1221), Expect = 1.722e-162
Identity = 258/471 (54.78%), Postives = 333/471 (70.70%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +RIE D+ GE++VP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N   G   N     I AA +      +    HFPLVVWQTGSGTQ+NMNVNEV+SN A + +G +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA V  +   L+P L+ L   +  K  EF  +IKIGRTH QDAVPLT+GQE   YV Q+ YS+ +I   +  V + LA GGTAVGTGL T  GF  +V  ++ +         + F  A NKF +LAAHD+L+ ++G LNTLA +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VAISIG S GH ELNV+KP+II+NVL SI++L D++  F   C+ G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE A+KL  ++ + FD+W+ P  ML PK
Sbjct:   24 YRIESDTFGELQVPNDKYYGAQTVRSTMNFKIGGVTERMPVPVIRAFGILKRAAAEVNQDYGLDPNIANFIIKAADEVSSGKLD---DHFPLVVWQTGSGTQTNMNVNEVISNRAIEMMGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAVKEVHEVLLPGLQKLHDALEEKSKEFENIIKIGRTHTQDAVPLTLGQEFGGYVQQIKYSVSRIKAALPRVYE-LAAGGTAVGTGLNTRIGFAEKVAAKVAELT------GLPFITAPNKFESLAAHDALVELSGALNTLACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAVTMVAAQVMGNHVAISIGCSNGHFELNVFKPVIIKNVLQSIRLLGDAAVSFTDNCIVGVQANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKETAIKLGFLTSDQFDQWVKPEDMLGPK 484
[Close]
BLAST of Fumarate hydratase vs. Ensembl Xenopus
Match: tpgs2 (tubulin polyglutamylase complex subunit 2 [Source:Xenbase;Acc:XB-GENE-5836444])

HSP 1 Score: 474.552 bits (1220), Expect = 3.328e-162
Identity = 259/471 (54.99%), Postives = 333/471 (70.70%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +RIE D+ GE++VP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N   G   N     I+ A D   S       HFPLVVWQTGSGTQ+NMNVNEV+SN A + +G +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA V  +   L+P L+ L   +  K  EF  +IKIGRTH QDAVPLT+GQE   YV Q+ YS+ +I   +  V + LA GGTAVGTGL T  GF  +V  ++ +         + F  A NKF +LAAHD+L+ ++G LNTLA +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VAISIG S GH ELNV+KP+II+NVL SI++L D++  F   C+ G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE A+KL  ++ + FD+W+ P  ML PK
Sbjct:   30 YRIESDTFGELQVPNDKYYGAQTVRSTMNFKIGGVTERMPVPVIRAFGILKRAAAEVNQDYGLDPNI-ANFIIKAADEVSS--GKLDDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMMGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAVKEVHEVLLPGLQKLHDALEEKSKEFENIIKIGRTHTQDAVPLTLGQEFGGYVQQIKYSVSRIKAALPRVYE-LAAGGTAVGTGLNTRIGFAEKVAAKVAELT------GLPFITAPNKFESLAAHDALVELSGALNTLACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAVTMVAAQVMGNHVAISIGCSNGHFELNVFKPVIIKNVLQSIRLLGDAAVSFTDNCIVGVQANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKETAIKLGFLTSDQFDQWVKPEDMLGPK 490
[Close]
BLAST of Fumarate hydratase vs. Ensembl Xenopus
Match: tpgs2 (tubulin polyglutamylase complex subunit 2 [Source:Xenbase;Acc:XB-GENE-5836444])

HSP 1 Score: 474.937 bits (1221), Expect = 3.885e-162
Identity = 258/471 (54.78%), Postives = 333/471 (70.70%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +RIE D+ GE++VP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N   G   N     I AA +      +    HFPLVVWQTGSGTQ+NMNVNEV+SN A + +G +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA V  +   L+P L+ L   +  K  EF  +IKIGRTH QDAVPLT+GQE   YV Q+ YS+ +I   +  V + LA GGTAVGTGL T  GF  +V  ++ +         + F  A NKF +LAAHD+L+ ++G LNTLA +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VAISIG S GH ELNV+KP+II+NVL SI++L D++  F   C+ G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE A+KL  ++ + FD+W+ P  ML PK
Sbjct:   42 YRIESDTFGELQVPNDKYYGAQTVRSTMNFKIGGVTERMPVPVIRAFGILKRAAAEVNQDYGLDPNIANFIIKAADEVSSGKLD---DHFPLVVWQTGSGTQTNMNVNEVISNRAIEMMGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAVKEVHEVLLPGLQKLHDALEEKSKEFENIIKIGRTHTQDAVPLTLGQEFGGYVQQIKYSVSRIKAALPRVYE-LAAGGTAVGTGLNTRIGFAEKVAAKVAELT------GLPFITAPNKFESLAAHDALVELSGALNTLACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAVTMVAAQVMGNHVAISIGCSNGHFELNVFKPVIIKNVLQSIRLLGDAAVSFTDNCIVGVQANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKETAIKLGFLTSDQFDQWVKPEDMLGPK 502
[Close]
BLAST of Fumarate hydratase vs. Ensembl Xenopus
Match: tpgs2 (tubulin polyglutamylase complex subunit 2 [Source:Xenbase;Acc:XB-GENE-5836444])

HSP 1 Score: 473.781 bits (1218), Expect = 8.469e-162
Identity = 259/471 (54.99%), Postives = 333/471 (70.70%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +RIE D+ GE++VP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N   G   N     I+ A D   S       HFPLVVWQTGSGTQ+NMNVNEV+SN A + +G +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA V  +   L+P L+ L   +  K  EF  +IKIGRTH QDAVPLT+GQE   YV Q+ YS+ +I   +  V + LA GGTAVGTGL T  GF  +V  ++ +         + F  A NKF +LAAHD+L+ ++G LNTLA +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VAISIG S GH ELNV+KP+II+NVL SI++L D++  F   C+ G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE A+KL  ++ + FD+W+ P  ML PK
Sbjct:   40 YRIESDTFGELQVPNDKYYGAQTVRSTMNFKIGGVTERMPVPVIRAFGILKRAAAEVNQDYGLDPNI-ANFIIKAADEVSS--GKLDDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMMGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAVKEVHEVLLPGLQKLHDALEEKSKEFENIIKIGRTHTQDAVPLTLGQEFGGYVQQIKYSVSRIKAALPRVYE-LAAGGTAVGTGLNTRIGFAEKVAAKVAELT------GLPFITAPNKFESLAAHDALVELSGALNTLACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAVTMVAAQVMGNHVAISIGCSNGHFELNVFKPVIIKNVLQSIRLLGDAAVSFTDNCIVGVQANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKETAIKLGFLTSDQFDQWVKPEDMLGPK 500
[Close]
BLAST of Fumarate hydratase vs. Ensembl Mouse
Match: Fh1 (fumarate hydratase 1 [Source:MGI Symbol;Acc:MGI:95530])

HSP 1 Score: 492.656 bits (1267), Expect = 3.174e-169
Identity = 254/475 (53.47%), Postives = 328/475 (69.05%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FR+E D+ GE+KVP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N + G L  K  ++I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  V +   L+P L+ L   +SAK  EFA+VIKIGRTH QDAVPLT+GQE S YV Q+ Y++ +I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F   CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   43 SQNSFRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYG-LDPKIASAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMVRIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 507
[Close]
BLAST of Fumarate hydratase vs. Ensembl Mouse
Match: Fh1 (fumarate hydratase 1 [Source:MGI Symbol;Acc:MGI:95530])

HSP 1 Score: 186.422 bits (472), Expect = 1.890e-55
Identity = 81/143 (56.64%), Postives = 111/143 (77.62%), Query Frame = 3 
Query: 1020 MPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            + GKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F   CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   25 LTGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 167
[Close]
BLAST of Fumarate hydratase vs. UniProt/SwissProt
Match: sp|P14408|FUMH_RAT (Fumarate hydratase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Fh PE=1 SV=2)

HSP 1 Score: 494.582 bits (1272), Expect = 4.034e-169
Identity = 255/475 (53.68%), Postives = 330/475 (69.47%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FRIE D+ GE+KVP   YYG+QT RS  NF++   T++MP  VIK+  +LK +AAE N + G L  K  ++I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  + +   L+P L+ L   +SAK  EFA+VIKIGRTH QDAVPLT+GQE S YV Q+ Y++++I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F + CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   43 SQNSFRIEYDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIKAFGILKRAAAEVNQEYG-LDPKIASAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAALEVHQVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMERIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 507
[Close]
BLAST of Fumarate hydratase vs. UniProt/SwissProt
Match: sp|P97807|FUMH_MOUSE (Fumarate hydratase, mitochondrial OS=Mus musculus OX=10090 GN=Fh PE=1 SV=3)

HSP 1 Score: 492.656 bits (1267), Expect = 2.220e-168
Identity = 254/475 (53.47%), Postives = 328/475 (69.05%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FR+E D+ GE+KVP   YYG+QT RS  NF++   T++MP  VI++  +LK +AAE N + G L  K  ++I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  V +   L+P L+ L   +SAK  EFA+VIKIGRTH QDAVPLT+GQE S YV Q+ Y++ +I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F   CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   43 SQNSFRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYG-LDPKIASAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMVRIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 507
[Close]
BLAST of Fumarate hydratase vs. UniProt/SwissProt
Match: sp|Q7SX99|FUMH_DANRE (Fumarate hydratase, mitochondrial OS=Danio rerio OX=7955 GN=fh PE=2 SV=1)

HSP 1 Score: 488.419 bits (1256), Expect = 1.395e-166
Identity = 253/475 (53.26%), Postives = 336/475 (70.74%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            SS+ FRIE+D+ GE+KVP   YYG+QT RS  NF +   T++MP  VI++  +LK +AAE N   G L  K   +I+ A D   S       HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG +LGSK+P+HPNDHVN SQSSNDTFPTAM+IA    +   L+P L+ L   ++AK  +F  +IKIGRTH QDAVPL++GQE   YV Q+ YS+ ++  ++  V +       A GT +GT     +   +++ D V       + F  A NKF ALAAHD+L+ ++G LNT+A ++MKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP+II+NVL+S ++L D+S  F   CV G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK+  +LKEAALKL  ++E+ F++W+ P  ML PK
Sbjct:   45 SSEAFRIERDTFGELKVPSDKYYGAQTVRSTMNFRIGGVTERMPIQVIRAFGILKKAAAEVNKDYG-LDPKIADAIMKAADEVES--GKLDDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAAAKEVHEVLLPGLQTLHDALAAKAEQFKDIIKIGRTHTQDAVPLSLGQEFGGYVQQVKYSIARVKASLPRVYE-----LAAGGTAVGTGLNTRIGFAEKVADKVSAL--TGLPFVTAANKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMIIKNVLNSARLLGDASVSFTNNCVVGIEANTERINKLMSESLMLVTALNPHIGYDKAAKIAKTAHKDGSTLKEAALKLGFLNEQQFEEWVRPHDMLGPK 509
[Close]
BLAST of Fumarate hydratase vs. UniProt/SwissProt
Match: sp|P07954|FUMH_HUMAN (Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3)

HSP 1 Score: 488.034 bits (1255), Expect = 1.914e-166
Identity = 253/475 (53.26%), Postives = 326/475 (68.63%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FRIE D+ GE+KVP   YYG+QT RS  NF++   T++MP  VIK+  +LK +AAE N   G L  K   +I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  + +   L+P L+ L   + AK  EFA++IKIGRTH QDAVPLT+GQE S YV Q+ Y++ +I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F + CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   46 SQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYG-LDPKIANAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 510
[Close]
BLAST of Fumarate hydratase vs. UniProt/SwissProt
Match: sp|Q60HF9|FUMH_MACFA (Fumarate hydratase, mitochondrial OS=Macaca fascicularis OX=9541 GN=FH PE=2 SV=1)

HSP 1 Score: 487.263 bits (1253), Expect = 4.228e-166
Identity = 253/475 (53.26%), Postives = 326/475 (68.63%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            S   FRIE D+ GE+KVP   YYG+QT RS  NF++   T++MP  VIK+  +LK +AAE N   G L  K   +I+ A D           HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG ELGSK P+HPNDHVN SQSSNDTFPTAM+IA  + +   L+P L+ L   + AK  EFA++IKIGRTH QDAVPLT+GQE S YV Q+ Y++ +I   +  + +           G     G +  +    K   K      + F  A NKF ALAAHD+L+ ++G +NT A +LMKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP++I+NVLHS ++L D+S  F + CV G+  N  +IN  +N+SLMLVTAL+P IGYDK+A+IAK +HKN  +LKE A++L  ++ E FD+W+ P  ML PK
Sbjct:   46 SQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYG-LDPKIANAIMKAADEVAE--GKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAVTRIKAAMPRIYE-------LAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK 510
[Close]
BLAST of Fumarate hydratase vs. TrEMBL
Match: A0A0K0F078 (Fumarate hydratase, mitochondrial (inferred by orthology to a human protein) OS=Strongyloides venezuelensis OX=75913 PE=3 SV=1)

HSP 1 Score: 504.597 bits (1298), Expect = 8.967e-171
Identity = 258/475 (54.32%), Postives = 332/475 (69.89%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            SS  FRIEKD+ GE+KVP   YYG+QT RS  NF++    ++MP  V+ +   LK +AA  N + G   N   A IV A D  ++       HFPLVVWQTGSGTQSNMNVNEV+SN A + LG +LGSK P+HPNDHVN SQSSNDTFPTAM+IA  + + N+L+P+L+ L+  + AK  EF K+IKIGRTH QDAVPLT+GQE S+YV Q++  + ++  T+  + +  A G               +   +++ D VK      + F  A NKF ALAAHD+++ V G LN +AT+LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCESL+M+ AQV GN VA+++G S GH ELNV+KP+I+RNVL SI+++AD S  F K CV+G+  N   I   +N+SLMLVTAL+P IGYD +A+IAK +HKN  +LKE A+KL +++EE FDKW+ P  ML+PK
Sbjct:   22 SSNSFRIEKDTFGELKVPSDKYYGAQTARSIMNFKIGGPEERMPLPVVHAFGYLKKAAAMVNTQYGLDKNLSDA-IVKAADEVIA--GKLDDHFPLVVWQTGSGTQSNMNVNEVISNRAIEILGGQLGSKTPVHPNDHVNKSQSSNDTFPTAMHIAVALEINNRLLPSLETLKQSLDAKAKEFEKIIKIGRTHTQDAVPLTLGQEFSAYVTQIENGIQRVKSTLPHLYQLAAGGTAVGTGLNTR-----IGFAEKVADTVKSL--TGLPFVTAPNKFEALAAHDTMVEVHGALNVIATSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMIAAQVFGNQVAVTVGGSNGHFELNVFKPMIVRNVLQSIRLIADGSVSFSKNCVDGIKANEDNIKKILNESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLKEEAIKLGILTEEQFDKWVRPEDMLAPK 486
[Close]
BLAST of Fumarate hydratase vs. TrEMBL
Match: A0A0N5CCQ0 (Uncharacterized protein OS=Strongyloides papillosus OX=174720 PE=3 SV=1)

HSP 1 Score: 502.671 bits (1293), Expect = 4.784e-170
Identity = 258/475 (54.32%), Postives = 332/475 (69.89%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            SS  FRIEKD+ GE+KVP   YYG+QT RS  NF++    ++MP  V+ +   LK +AA  N + G   N   A IV A D  ++       HFPLVVWQTGSGTQSNMNVNEV+SN A + LG +LGSK P+HPNDHVN SQSSNDTFPTAM+IA  + + N+L+P+L+ LR  + AK  EF K+IKIGRTH QDAVPLT+GQE S+YV Q++  + ++  T+  + +  A G               +   +++ D VK      + F  A NKF ALAAHD+++ V G LN +AT+LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCESL+M+ AQV GN VA+++G S GH ELNV+KP+I+RNVL SI+++AD S  F K CV+G+  N   I   +N+SLMLVTAL+P IGYD +A+IAK +HKN  +LKE A+KL +++EE F+KW+ P  ML+PK
Sbjct:   22 SSNSFRIEKDTFGELKVPSDKYYGAQTARSIMNFKIGGPEERMPLPVVHAFGYLKKAAAMVNTQYGLDKNLSDA-IVKAADEVIA--GKLDDHFPLVVWQTGSGTQSNMNVNEVISNRAIEILGGQLGSKTPVHPNDHVNKSQSSNDTFPTAMHIAVALEVNNRLLPSLEILRQSLDAKAKEFEKIIKIGRTHTQDAVPLTLGQEFSAYVTQIENGIQRVKSTLPHLYQLAAGGTAVGTGLNTR-----IGFAEKVADTVKSL--TGLPFVTAPNKFEALAAHDTMVEVHGALNVIATSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMIAAQVFGNQVAVTVGGSNGHFELNVFKPMIVRNVLQSIRLIADGSVSFSKNCVDGIKANEDNIKKILNESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLKEEAIKLGILTEEQFNKWVRPEDMLAPK 486
[Close]
BLAST of Fumarate hydratase vs. TrEMBL
Match: E9G631 (Uncharacterized protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_46417 PE=3 SV=1)

HSP 1 Score: 498.819 bits (1283), Expect = 8.800e-169
Identity = 268/474 (56.54%), Postives = 343/474 (72.36%), Query Frame = 3 
Query:   27 SKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            + GFRIE D+ GE++VP + YYG+QT RS  NF +  +++KMP  VIK+  +LK +AAE N   G L  K  ASI  A D  + D + +  HFPLV+WQTGSGTQSNMNVNEV+SN A + +G  LGSK P+HPNDHVN SQSSNDT+PTAM+IA  V +T+ L+P+L+ L   I AK  EF  +IKIGRTH QDA PLT+GQE S Y  Q+ + ++++  ++  V   LA GGTAVGTGL T  GF  +V  R+ +         + F  A NKF ALA+HD+L+ ++G LNT+A +LMKIAND R L SGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA++IG S GH ELNV+KPLI+ NVL SI++LADSS  F K CV G+  N  +IN  +++SLMLVTAL+P IGYDK+A+IAK +HK   +LKE ALKL  ++EE F++W+ P  ML PK
Sbjct:    2 ASGFRIEADTFGELQVPDNKYYGAQTVRSTMNFPIGGESEKMPLPVIKAFGVLKKAAAEVNQDYG-LDPKIAASISQACDEVVIDGSLYADHFPLVIWQTGSGTQSNMNVNEVISNRAIEIMGGVLGSKKPVHPNDHVNKSQSSNDTYPTAMHIAVAVEVTSNLLPSLQRLHDAIDAKAKEFQDIIKIGRTHTQDATPLTLGQEFSGYAQQIAFGIERVKASLPHVYM-LAAGGTAVGTGLNTRIGFAEKVAARVSELT------GLPFVTAPNKFEALASHDALVQMSGSLNTVAVSLMKIANDIRFLASGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVAAQVMGNHVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLADSSNAFTKNCVVGIEANRDRINKLLHESLMLVTALNPHIGYDKAAKIAKTAHKEGSTLKETALKLGYLTEEQFNQWVKPEDMLGPK 467
[Close]
BLAST of Fumarate hydratase vs. TrEMBL
Match: A0A090L4W0 (Fumarate hydratase, mitochondrial OS=Strongyloides ratti OX=34506 GN=SRAE_1000298500 PE=3 SV=1)

HSP 1 Score: 498.049 bits (1281), Expect = 1.529e-168
Identity = 258/475 (54.32%), Postives = 336/475 (70.74%), Query Frame = 3 
Query:   24 SSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            SS  FR+EKD+ GE+KVP   YYG+QT RS  NF++    ++MP  V+ +   LK +AA  N + G L  +   +IV A D  ++       HFPLVVWQTGSGTQSNMNVNEV+SN A + LG +LGSK P+HPNDHVN SQSSNDTFPTAM+IA  + + N+L+P+L  LR  ++AK  EF K+IKIGRTH QDAVPLT+GQE S+YV Q++  + +I  T+  + +       A GT +GT     +   +++ + VK      + F  A NKF ALAAHD+++ V G LN +AT+LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCESL+M+ AQV GN VA+++G S GH ELNV+KP+I++NVL SI+++AD    F K CV+G+  N   I   +N+SLMLVTAL+P IGYD +A+IAK +HKN  +LKE A+KL +++EE FDKW+ P  ML+PK
Sbjct:    2 SSDSFRVEKDTFGELKVPSDKYYGAQTARSIMNFKIGGPEERMPLPVVHAFGYLKKAAAIVNTQYG-LDKQVSDAIVKAADEVIA--GKLDDHFPLVVWQTGSGTQSNMNVNEVISNRAIELLGGQLGSKTPVHPNDHVNKSQSSNDTFPTAMHIAVALEINNRLLPSLNTLRHSLAAKAKEFEKIIKIGRTHTQDAVPLTLGQEFSAYVTQIENGIVRIQSTLPHLYQ-----LAAGGTAVGTGLNTRIGFAEKVAETVKSL--TGLPFVTAPNKFEALAAHDTMVEVHGALNVIATSLMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCESLTMIAAQVFGNQVAVTVGGSNGHFELNVFKPMIVKNVLQSIRLIADGCVSFSKNCVDGIKANEANIKKILNESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLKEEAVKLGILTEEQFDKWVRPEDMLAPK 466
[Close]
BLAST of Fumarate hydratase vs. TrEMBL
Match: A0A1W4VEK0 (fumarate hydratase, mitochondrial OS=Drosophila ficusphila OX=30025 GN=LOC108097085 PE=3 SV=1)

HSP 1 Score: 498.819 bits (1283), Expect = 2.366e-168
Identity = 275/476 (57.77%), Postives = 344/476 (72.27%), Query Frame = 3 
Query:   21 KSSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            K+S  FR+EKD+ GE++VP    YG+QT RSK NF +    ++MP  VI+++ +LK + AE N + G L +K   ++  A D  +S  +  + HFPLV+WQTGSGTQSNMN NEV+SN A K LG ELGSK P+HPNDHVN SQSSNDTFPTA++IA  + L  +L+P L  LR  + +K  EF  +IKIGRTH+ DAVPLT+GQE S Y  QL Y L++I K  +     LA+GGTAVGTGL T  GF  +V KR+ +         + F  A NKF ALAA D+++ V G LNT+A +LMKIAND RLLGSGPRCG GE +LPENEPGSSIMPGKVNPTQCES++M+CAQVMGN VA+SIG S GH ELNV+KPLI+ NVL SI++LAD S  F K CVEGL  N   I+  +N+SLMLVTAL+P IGYDKSAQIAK +HKN  +LKE ALK + ++EE F +W++P +ML PK
Sbjct:   33 KASDKFRMEKDTFGELQVPADKLYGAQTMRSKLNFPIGGIAERMPMPVIQAMGILKKACAEVNKEFG-LDSKIADAVSCACDDVISGKHYKQGHFPLVIWQTGSGTQSNMNTNEVISNAAIKMLGGELGSKTPVHPNDHVNKSQSSNDTFPTAIHIAVGMELNERLVPGLTHLRNALKSKSDEFKDIIKIGRTHLMDAVPLTLGQEFSGYTQQLSYGLERI-KCCQPRVYELALGGTAVGTGLNTHKGFAEKVAKRIAELT------CLPFVSAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGFGELMLPENEPGSSIMPGKVNPTQCESMTMLCAQVMGNQVAVSIGGSNGHFELNVFKPLIVSNVLRSIRLLADGSMSFSKNCVEGLQANKDAIDKIMNESLMLVTALNPHIGYDKSAQIAKAAHKNKTTLKEEALK-EGITEEQFKEWVNPKEMLGPK 499
[Close]
BLAST of Fumarate hydratase vs. Ensembl Yeast
Match: FUM1 (Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria [Source:SGD;Acc:S000006183])

HSP 1 Score: 442.195 bits (1136), Expect = 1.188e-150
Identity = 241/471 (51.17%), Postives = 329/471 (69.85%), Query Frame = 3 
Query:   36 FRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            FR E D+ GEI VP   Y+G+QT+RS +NF++    ++MP  ++ +  +LK SAA  N  LG L  K   +I  A D   S       HFPLVV+QTGSGTQSNMN NEV+SN A + LG ++GSK  +HPN+H N SQSSNDTFPT M+IA  + + N+LIP L +L+  + AK  EF  ++KIGRTH+QDA PLT+GQE S YV Q++  + ++  ++K ++  LA GGTAVGTGL T  GFDV++ +++           + F  A NKF ALAAHD+++  +G LNTLA +L KIA D R LGSGPRCG  E +LPENEPGSSIMPGKVNPTQ E+L+ VC QVMGN  AI+   SQG  ELNV+KP++I N+L+SI+++ D++  F  +CVEG+  N  +I+  + +SLMLVTAL+P IGYD ++++AK +HK   +LKE+AL+L +++E++FD+W+ P  ML PK
Sbjct:   28 FRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEVAS--GKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQ-VHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLS-FLAQGGTAVGTGLNTKPGFDVKIAEQISKET------GLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK 488
[Close]
BLAST of Fumarate hydratase vs. Ensembl Nematostella
Match: EDO31211 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYK1])

HSP 1 Score: 455.292 bits (1170), Expect = 3.722e-155
Identity = 254/470 (54.04%), Postives = 330/470 (70.21%), Query Frame = 3 
Query:   39 RIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            RIE DS GEI+VP   YYG+QT RSK NF +  +++KMP  VI++   LK +AAE N + G L      +I+ A D  +S     K HFPLVVWQTGSGTQSNMNVNEV+SN A + +G E+GSK P+HPNDHVN SQSSNDTFPTAM++A  + +  +L+P LK L   + AK  EF  +IKIGRTH QDA PLT+GQE S YV Q++  + ++   +  V + LAIGGTAVGTGL T  GF  +V  ++ +  K      + F    NKF  LAAHD+++ + G LN +A +LMKIAND R LGSGPRCG+GE  LPENEPGSSIMPGKVNPTQCE+++MV AQV+GN  A+S+G S GH ELNV+KP+I+RNVL S +++ D+   F   CV G+  N  +I+  +++SLMLVTAL+P +GYD +A+IAK +HK   +LKEAA+ L L++ E FD+W+ P  ML PK
Sbjct:   39 RIETDSFGEIEVPSEKYYGAQTARSKHNFPIGDESEKMPFPVIRAFGYLKKAAAEVNKEFG-LDGPVADNIMRAADEVIS--GKLKDHFPLVVWQTGSGTQSNMNVNEVISNRAIELMGGEMGSKKPVHPNDHVNKSQSSNDTFPTAMHVACAIEVHERLLPGLKKLHGALDAKAKEFKDIIKIGRTHTQDATPLTLGQEFSGYVKQIENGIARVQVCMPRVYE-LAIGGTAVGTGLNTRIGFAEKVSAKIAEYTK------LPFTSNPNKFEGLAAHDAMVELHGALNVIACSLMKIANDVRFLGSGPRCGLGELQLPENEPGSSIMPGKVNPTQCEAITMVAAQVIGNQTAVSVGGSNGHFELNVFKPMIVRNVLQSTRLIGDACVAFTDNCVNGIIANRDRISALLHESLMLVTALNPHVGYDNAAKIAKKAHKEGTTLKEAAISLGLLTSEQFDEWVRPEDMLGPK 498
[Close]
BLAST of Fumarate hydratase vs. Ensembl Nematostella
Match: EDO36216 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ56])

HSP 1 Score: 101.293 bits (251), Expect = 1.679e-25
Identity = 69/135 (51.11%), Postives = 89/135 (65.93%), Query Frame = 3 
Query:  609 DAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGS 1013
            DA PLT+GQE S YV Q++  + ++   +  V + LAIGGTAVGTGL T  GF  +V  ++ +  K      + F    NKF  LAAHD+++ + G LN +A +LMKIAND R LGSGPRCG+GE  LPENEPGS
Sbjct:    1 DATPLTLGQEFSGYVKQIENGIARVQVCMPRVYE-LAIGGTAVGTGLNTRIGFAEKVSAKIAEYTK------LPFTSNPNKFEGLAAHDAMVELHGALNVIACSLMKIANDVRFLGSGPRCGLGELQLPENEPGS 128
[Close]
BLAST of Fumarate hydratase vs. Ensembl Medaka
Match: fh (fumarate hydratase [Source:NCBI gene;Acc:101159576])

HSP 1 Score: 481.485 bits (1238), Expect = 4.702e-165
Identity = 250/483 (51.76%), Postives = 333/483 (68.94%), Query Frame = 3 
Query:   15 NGKSSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMPELVXXXXXXXXXXXXEANLKLGC-----LTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            +G ++ G+RIE+D+ GE+KVP   YYG+QT RS  NF++   +++MP  VIK+  +LK +AAE N + G            A  V+AG   L D      HFPLVVWQTGSGTQ+NMNVNEV+SN A + LG  LGSK+P+HPNDHVN SQSSNDTFPTAM+IA    +   L+P L+ L + +SAK  EF  +IKIGRTH QDAVPL++GQE S YV Q+ YS++++   +  V +  A G               +   +++   V       + F  A NKF ALAAHD+L+ ++G LNT+A ++MKIAND R LGSGPR G+GE +LPENEPGSSIMPGKVNPTQCE+++MV AQVMGN+VA+++G S GH ELNV+KP+I++NVL+S Q+L D++  F   CV G+  N  +IN  +++SLMLVTAL+P IGYDK+A IAK +HK   +LK  A++L  +SEE FD+W+ PS+ML PK
Sbjct:   32 SGMAASGYRIERDTFGELKVPADKYYGAQTVRSTMNFKIGGPSERMPIQVIKAFGILKKAAAEVNKEFGLDPKLAAAIIQAAEEVSAGK--LDD------HFPLVVWQTGSGTQTNMNVNEVISNRAIEILGGTLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAVATEVHQVLLPGLQTLHSALSAKAEEFKDIIKIGRTHTQDAVPLSLGQEFSGYVQQVKYSIERVKAAMPRVYELAAGGTAVGTGLNTR-----IGFAEKVASVVASL--TGLPFVTAPNKFEALAAHDALVELSGALNTVAVSMMKIANDIRFLGSGPRSGLGELVLPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMIVKNVLNSAQLLGDAAVSFTDNCVVGIQANTDRINKLMSESLMLVTALNPHIGYDKAAAIAKTAHKKGSTLKAVAVELGYLSEEQFDQWVKPSEMLGPK 499
[Close]
BLAST of Fumarate hydratase vs. Planmine SMEST
Match: SMESG000048275.1 (SMESG000048275.1)

HSP 1 Score: 826.239 bits (2133), Expect = 0.000e+0
Identity = 433/433 (100.00%), Postives = 433/433 (100.00%), Query Frame = 3 
Query:  150 MPELVXXXXXXXXXXXXEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHXXXXXXXXXXXXXXXXXFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 1448
            MPELVIKSLILLKISAAEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHLAIGGTAVGTGLGTVAGFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK
Sbjct:    1 MPELVIKSLILLKISAAEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHFPLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQSSNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHMQDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHLAIGGTAVGTGLGTVAGFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLNTLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCESLSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKCFVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNNCSLKEAALKLKLVSEEDFDKWLDPSKMLSPK 433
The following BLAST results are available for this feature:
BLAST of Fumarate hydratase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
FH3.985e-16753.26fumarate hydratase [Source:HGNC Symbol;Acc:HGNC:37... [more]
AMACR3.448e-1653.23alpha-methylacyl-CoA racemase [Source:HGNC Symbol;... [more]
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BLAST of Fumarate hydratase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fum-13.994e-16553.07Probable fumarate hydratase, mitochondrial [Sourc... [more]
fum-15.625e-12053.71Probable fumarate hydratase, mitochondrial [Sourc... [more]
fum-15.625e-12053.71Probable fumarate hydratase, mitochondrial [Sourc... [more]
fum-15.625e-12053.71Probable fumarate hydratase, mitochondrial [Sourc... [more]
fum-15.625e-12053.71Probable fumarate hydratase, mitochondrial [Sourc... [more]
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BLAST of Fumarate hydratase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fum11.629e-16655.16gene:FBgn0286222 transcript:FBtr0070954[more]
Fum13.331e-16655.16gene:FBgn0286222 transcript:FBtr0070953[more]
Fum23.050e-16556.48gene:FBgn0029890 transcript:FBtr0070955[more]
Fum31.162e-15253.52gene:FBgn0036162 transcript:FBtr0076177[more]
Fum31.162e-15253.52gene:FBgn0036162 transcript:FBtr0331828[more]
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BLAST of Fumarate hydratase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
fh1.768e-16653.26fumarate hydratase [Source:NCBI gene;Acc:393938][more]
CABZ01084963.18.885e-9450.87fumarate hydratase, mitochondrial-like [Source:NCB... [more]
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BLAST of Fumarate hydratase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tpgs24.313e-16354.07tubulin polyglutamylase complex subunit 2 [Source:... [more]
tpgs21.722e-16254.78tubulin polyglutamylase complex subunit 2 [Source:... [more]
tpgs23.328e-16254.99tubulin polyglutamylase complex subunit 2 [Source:... [more]
tpgs23.885e-16254.78tubulin polyglutamylase complex subunit 2 [Source:... [more]
tpgs28.469e-16254.99tubulin polyglutamylase complex subunit 2 [Source:... [more]
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BLAST of Fumarate hydratase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Fh13.174e-16953.47fumarate hydratase 1 [Source:MGI Symbol;Acc:MGI:95... [more]
Fh11.890e-5556.64fumarate hydratase 1 [Source:MGI Symbol;Acc:MGI:95... [more]
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BLAST of Fumarate hydratase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P14408|FUMH_RAT4.034e-16953.68Fumarate hydratase, mitochondrial OS=Rattus norveg... [more]
sp|P97807|FUMH_MOUSE2.220e-16853.47Fumarate hydratase, mitochondrial OS=Mus musculus ... [more]
sp|Q7SX99|FUMH_DANRE1.395e-16653.26Fumarate hydratase, mitochondrial OS=Danio rerio O... [more]
sp|P07954|FUMH_HUMAN1.914e-16653.26Fumarate hydratase, mitochondrial OS=Homo sapiens ... [more]
sp|Q60HF9|FUMH_MACFA4.228e-16653.26Fumarate hydratase, mitochondrial OS=Macaca fascic... [more]
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BLAST of Fumarate hydratase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0K0F0788.967e-17154.32Fumarate hydratase, mitochondrial (inferred by ort... [more]
A0A0N5CCQ04.784e-17054.32Uncharacterized protein OS=Strongyloides papillosu... [more]
E9G6318.800e-16956.54Uncharacterized protein OS=Daphnia pulex OX=6669 G... [more]
A0A090L4W01.529e-16854.32Fumarate hydratase, mitochondrial OS=Strongyloides... [more]
A0A1W4VEK02.366e-16857.77fumarate hydratase, mitochondrial OS=Drosophila fi... [more]
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BLAST of Fumarate hydratase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Fumarate hydratase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Fumarate hydratase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
FUM11.188e-15051.17Fumarase; converts fumaric acid to L-malic acid in... [more]
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BLAST of Fumarate hydratase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO312113.722e-15554.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO362161.679e-2551.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Fumarate hydratase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fh4.702e-16551.76fumarate hydratase [Source:NCBI gene;Acc:101159576... [more]
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BLAST of Fumarate hydratase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000048275.10.000e+0100.00SMESG000048275.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014122 ID=SMED30014122|Name=Fumarate hydratase|organism=Schmidtea mediterranea sexual|type=transcript|length=1861bp
ATTGAATGACAGAAAACGGAAAGAGTTCAAAGGGTTTTCGAATTGAAAAA
GATTCCATTGGTGAAATCAAGGTTCCTATATCTGCATACTATGGAAGTCA
AACTGAAAGATCTAAAAAGAATTTTGAAGTTGCTGTAGACACTGACAAAA
TGCCTGAATTAGTTATTAAATCATTAATATTACTTAAAATATCAGCTGCA
GAAGCTAATTTAAAACTTGGTTGTCTTACAAATAAGGATTGCGCTAGTAT
TGTAGCAGCTGGTGATACATGCCTTTCAGATTTCAATACGTGGAAGCAGC
ATTTTCCATTGGTTGTATGGCAAACAGGTTCTGGAACCCAGTCAAACATG
AATGTAAACGAGGTATTGTCGAATTTAGCTAATAAGTCTCTGGGATTTGA
ATTAGGTTCTAAAAACCCGATTCATCCAAATGATCATGTCAATATGAGCC
AGAGTTCCAATGATACGTTTCCAACTGCAATGAACATTGCCACTGTTGTA
GCGCTAACAAATCAGTTGATTCCTGCCCTTAAAGATTTACGGGCTGGTAT
TTCTGCAAAAGAGGTTGAATTTGCCAAAGTTATAAAAATCGGGCGCACTC
ATATGCAGGATGCAGTTCCATTAACTGTTGGGCAAGAATTAAGTAGCTAT
GTCAATCAATTGGATTATAGTCTTGATAAAATTACTAAAACCGTTAAAAT
AGTCGCTAAACATTTGGCTATTGGAGGGACTGCTGTTGGAACTGGACTGG
GAACTGTCGCTGGGTTCGACGTTGAAGTTTGTAAGCGACTAAAGGACAAT
GTTAAAAAATACTTGAATGTTAATGTGGACTTTGGTCCAGCTCAAAATAA
ATTCTCAGCGTTAGCAGCTCATGATTCATTAATGACTGTTGCTGGGGATT
TAAATACTTTAGCAACTGCTCTAATGAAAATTGCAAATGATTTCCGTCTA
CTTGGTTCTGGTCCTCGTTGTGGAATAGGAGAATTTTTGTTGCCAGAAAA
TGAACCCGGTTCTAGCATAATGCCGGGGAAAGTCAACCCAACGCAATGTG
AATCTTTGTCAATGGTATGCGCACAAGTAATGGGTAACTATGTGGCGATT
TCCATTGGGTCGAGTCAGGGTCATCTTGAGTTGAATGTATATAAACCGCT
TATTATACGAAATGTGTTGCATTCTATTCAAATGTTAGCGGATTCCAGTA
AATGCTTTGTAAAATATTGCGTGGAAGGATTGAATCTTAATCTGACTCAA
ATTAATACCTATGTGAATCAATCCTTGATGCTAGTTACCGCATTGAGTCC
ATTCATTGGTTATGATAAATCTGCTCAAATTGCCAAATATTCCCATAAAA
ATAATTGCAGTTTAAAAGAAGCCGCGTTAAAATTAAAATTAGTCAGTGAA
GAAGACTTTGATAAGTGGTTAGATCCATCAAAAATGCTTTCTCCTAAATA
ATTAAGTTTTGGGTTTTCTATTCGATTCATTACTTATTAATTTACTTTTA
TTTTATTTTCAATAATTTTTGGTAATGAGATTTTGATTAACTAGTTTGTT
TAAATATTTAATAACATGCAAATTAGAAGTATTATGTGGTTGGTTTGTGG
GTTTTCAATTCAAAGATCTATATTGCCGTTGCTAGACAATGCCATACAAA
ATAGTACTGCTACTACTCGGTATCCGTTAGACAGCGTTGGACAAAGTAAG
TGATGTTATTTATCAAACGTACCTCGAGTTCATCGGGCTATCGATAGGAG
CTCTGTGCTTGATTTTAAAATTTGTGGTTCCTTTAACAAATCATATTTCT
ACTCTGATTTGAAATTATCCTTTATTTTATCACCGAAACCCTTGTCATTC
CAATTAAAATA
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protein sequence of SMED30014122-orf-1

>SMED30014122-orf-1 ID=SMED30014122-orf-1|Name=SMED30014122-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=482bp
MTENGKSSKGFRIEKDSIGEIKVPISAYYGSQTERSKKNFEVAVDTDKMP
ELVIKSLILLKISAAEANLKLGCLTNKDCASIVAAGDTCLSDFNTWKQHF
PLVVWQTGSGTQSNMNVNEVLSNLANKSLGFELGSKNPIHPNDHVNMSQS
SNDTFPTAMNIATVVALTNQLIPALKDLRAGISAKEVEFAKVIKIGRTHM
QDAVPLTVGQELSSYVNQLDYSLDKITKTVKIVAKHLAIGGTAVGTGLGT
VAGFDVEVCKRLKDNVKKYLNVNVDFGPAQNKFSALAAHDSLMTVAGDLN
TLATALMKIANDFRLLGSGPRCGIGEFLLPENEPGSSIMPGKVNPTQCES
LSMVCAQVMGNYVAISIGSSQGHLELNVYKPLIIRNVLHSIQMLADSSKC
FVKYCVEGLNLNLTQINTYVNQSLMLVTALSPFIGYDKSAQIAKYSHKNN
CSLKEAALKLKLVSEEDFDKWLDPSKMLSPK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR005677Fum_hydII
IPR000362Fumarate_lyase_fam
IPR022761Fumarate_lyase_N
IPR018951Fumarase_C_C
IPR024083Fumarase/histidase_N
IPR020557Fumarate_lyase_CS
IPR008948L-Aspartase-like
Vocabulary: molecular function
TermDefinition
GO:0016829lyase activity
GO:0003824catalytic activity
GO:0004333fumarate hydratase activity
Vocabulary: biological process
TermDefinition
GO:0006099tricarboxylic acid cycle
GO:0006106fumarate metabolic process
Vocabulary: cellular component
TermDefinition
GO:0045239tricarboxylic acid cycle enzyme complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000362Fumarate lyase familyPRINTSPR00149FUMRATELYASEcoord: 144..162
score: 39.69
coord: 288..315
score: 30.9
coord: 190..208
score: 50.41
coord: 334..350
score: 65.32
IPR022761Fumarate lyase, N-terminalPFAMPF00206Lyase_1coord: 18..359
e-value: 1.8E-94
score: 316.6
NoneNo IPR availableGENE3DG3DSA:1.10.40.30coord: 425..480
e-value: 4.1E-25
score: 89.5
NoneNo IPR availableGENE3DG3DSA:1.20.200.10coord: 149..423
e-value: 1.5E-104
score: 350.9
NoneNo IPR availablePANTHERPTHR11444:SF1FUMARATE HYDRATASE, MITOCHONDRIALcoord: 9..480
IPR005677Fumarate hydratase, class IITIGRFAMTIGR00979TIGR00979coord: 10..477
e-value: 1.1E-200
score: 665.2
IPR005677Fumarate hydratase, class IIPANTHERPTHR11444ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASEcoord: 9..480
IPR005677Fumarate hydratase, class IICDDcd01362Fumarase_classIIcoord: 11..476
e-value: 0.0
score: 739.314
IPR018951Fumarase C, C-terminalPFAMPF10415FumaraseC_Ccoord: 425..477
e-value: 2.9E-22
score: 78.8
IPR024083Fumarase/histidase, N-terminalGENE3DG3DSA:1.10.275.10coord: 11..148
e-value: 5.7E-47
score: 161.3
IPR020557Fumarate lyase, conserved sitePROSITEPS00163FUMARATE_LYASEScoord: 334..343
IPR008948L-Aspartase-likeSUPERFAMILYSSF48557L-aspartase-likecoord: 10..477