RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30014025
Length (bp)	1170

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30014025) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30014025) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30014025) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30014025) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30014025

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30014025	SMESG000045407.1	dd_Smed_v4_6964_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30014025	SMESG000045407.1	dd_Smed_v4_6964_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30014025	SMESG000045407.1	dd_Smed_v4_6964_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: ANKRD2 (ankyrin repeat domain 2 [Source:HGNC Symbol;Acc:HGNC:495])

HSP 1 Score: 60.8474 bits (146), Expect = 8.301e-10
Identity = 37/107 (34.58%), Postives = 56/107 (52.34%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
            T+L  A  +G  E L KLL +G  V+ Q+    T +H AC  GH+ +VKLL     +  + D +GD  +H  V L  Y II  L  +  D++  KN  G++  D+ +
Sbjct:  156 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM-TKNLAGKTPTDLVQ 261

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: ANKRD2 (ankyrin repeat domain 2 [Source:HGNC Symbol;Acc:HGNC:495])

HSP 1 Score: 61.2326 bits (147), Expect = 9.386e-10
Identity = 37/107 (34.58%), Postives = 56/107 (52.34%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
            T+L  A  +G  E L KLL +G  V+ Q+    T +H AC  GH+ +VKLL     +  + D +GD  +H  V L  Y II  L  +  D++  KN  G++  D+ +
Sbjct:  183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM-TKNLAGKTPTDLVQ 288

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: FPGT-TNNI3K (FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HGNC:42952])

HSP 1 Score: 61.6178 bits (148), Expect = 1.124e-9
Identity = 50/147 (34.01%), Postives = 67/147 (45.58%), Query Frame = 2

Query:  269 CRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI----YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            C G  S IR   L G   S +T   F+   + V KDN E     LH     +I ++     T+L  A   G  E    LL HG NVN+Q+    TP+H+A Y GH  + +LLLKF  +  +    GD P+H        +I   L E
Sbjct:  178 CGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 322

HSP 2 Score: 55.8398 bits (133), Expect = 9.788e-8
Identity = 36/98 (36.73%), Postives = 52/98 (53.06%), Query Frame = 2

Query:  398 VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            VNI +   +T L  A   G E+  R LL  G +VNV  E G  P+HLA   G +NI KLL++     +    DN+  +P+H      H+DI+ YL ++
Sbjct:  261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: FPGT-TNNI3K (FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HGNC:42952])

HSP 1 Score: 61.6178 bits (148), Expect = 1.291e-9
Identity = 50/147 (34.01%), Postives = 67/147 (45.58%), Query Frame = 2

Query:  269 CRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI----YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            C G  S IR   L G   S +T   F+   + V KDN E     LH     +I ++     T+L  A   G  E    LL HG NVN+Q+    TP+H+A Y GH  + +LLLKF  +  +    GD P+H        +I   L E
Sbjct:  191 CGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 335

HSP 2 Score: 56.225 bits (134), Expect = 7.348e-8
Identity = 36/98 (36.73%), Postives = 52/98 (53.06%), Query Frame = 2

Query:  398 VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            VNI +   +T L  A   G E+  R LL  G +VNV  E G  P+HLA   G +NI KLL++     +    DN+  +P+H      H+DI+ YL ++
Sbjct:  274 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 371

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: FPGT-TNNI3K (FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HGNC:42952])

HSP 1 Score: 61.2326 bits (147), Expect = 1.620e-9
Identity = 50/147 (34.01%), Postives = 67/147 (45.58%), Query Frame = 2

Query:  269 CRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI----YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            C G  S IR   L G   S +T   F+   + V KDN E     LH     +I ++     T+L  A   G  E    LL HG NVN+Q+    TP+H+A Y GH  + +LLLKF  +  +    GD P+H        +I   L E
Sbjct:  178 CGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 322

HSP 2 Score: 55.8398 bits (133), Expect = 9.657e-8
Identity = 36/98 (36.73%), Postives = 52/98 (53.06%), Query Frame = 2

Query:  398 VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            VNI +   +T L  A   G E+  R LL  G +VNV  E G  P+HLA   G +NI KLL++     +    DN+  +P+H      H+DI+ YL ++
Sbjct:  261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nphp-2 (NePHronoPhthisis (Human kidney disease) homolog [Source:UniProtKB/TrEMBL;Acc:A0A0K3AVZ6])

HSP 1 Score: 59.3066 bits (142), Expect = 2.516e-9
Identity = 35/107 (32.71%), Postives = 56/107 (52.34%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHG-ENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            +T+LF A++ G  E   KLL    N N Q++   T  H A   G + ++KLL +FN +F I + +GDLP H  V     D++ +L      +L+  N  G++   +A
Sbjct:  245 HTALFYAISFGHYESALKLLQNNANPNHQDQRLATAAHSAASKGQMRMLKLLKQFNASFDIQNYRGDLPFHEAVQAGSKDVVEWLLAVDESVLDIPNHNGRTAIHLA 351

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nphp-2 (NePHronoPhthisis (Human kidney disease) homolog [Source:UniProtKB/TrEMBL;Acc:A0A0K3AVZ6])

HSP 1 Score: 59.3066 bits (142), Expect = 2.700e-9
Identity = 35/107 (32.71%), Postives = 56/107 (52.34%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHG-ENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            +T+LF A++ G  E   KLL    N N Q++   T  H A   G + ++KLL +FN +F I + +GDLP H  V     D++ +L      +L+  N  G++   +A
Sbjct:  245 HTALFYAISFGHYESALKLLQNNANPNHQDQRLATAAHSAASKGQMRMLKLLKQFNASFDIQNYRGDLPFHEAVQAGSKDVVEWLLAVDESVLDIPNHNGRTAIHLA 351

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: trp-4 (TRP (Transient receptor potential) channel family [Source:UniProtKB/TrEMBL;Acc:Q9GRV5])

HSP 1 Score: 49.6766 bits (117), Expect = 3.734e-6
Identity = 30/107 (28.04%), Postives = 51/107 (47.66%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            ++ L +A  +G       LL H   ++V +E G+T +HLA + GH+++V LLL+           G+ P+H      H  ++N L ++    LEA     Q+    A
Sbjct:  888 WSPLLEACARGHSGVANILLKHHARIDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKSKTGEAPLHLAAQHGHVKVVNVLVQDHGAALEAITLDNQTALHFA 994

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: F40G9.17 (pep chromosome:WBcel235:III:194460:210063:1 gene:WBGene00185078.1 transcript:F40G9.17.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F40G9.17)

HSP 1 Score: 48.1358 bits (113), Expect = 3.892e-6
Identity = 35/116 (30.17%), Postives = 58/116 (50.00%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVNVQ--NEFGQTPIHLACYLGHINIVKLLLKFNPNFY-IPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA--ENKND 748
            +T L  A + G  + +R LL   +V+V+  N   QT +H AC   H+ IVKLL++ +PN   +PD  G   +H      +  I+  L       L+ ++ +G +   +A  EN+ D
Sbjct:   85 WTPLMIASSAGRVDVVRYLLTLPDVDVKHTNSNKQTSLHYACSKNHVEIVKLLIEADPNIINLPDKFGATALHRAASRGNDVIVRALVSTGKCSLDRQDGEGNTALHLACDENRGD 200

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: F40G9.17 (pep chromosome:WBcel235:III:194462:200328:1 gene:WBGene00185078.1 transcript:F40G9.17.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F40G9.17)

HSP 1 Score: 48.1358 bits (113), Expect = 3.892e-6
Identity = 35/116 (30.17%), Postives = 58/116 (50.00%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVNVQ--NEFGQTPIHLACYLGHINIVKLLLKFNPNFY-IPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA--ENKND 748
            +T L  A + G  + +R LL   +V+V+  N   QT +H AC   H+ IVKLL++ +PN   +PD  G   +H      +  I+  L       L+ ++ +G +   +A  EN+ D
Sbjct:   85 WTPLMIASSAGRVDVVRYLLTLPDVDVKHTNSNKQTSLHYACSKNHVEIVKLLIEADPNIINLPDKFGATALHRAASRGNDVIVRALVSTGKCSLDRQDGEGNTALHLACDENRGD 200

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303123)

HSP 1 Score: 55.4546 bits (132), Expect = 7.933e-8
Identity = 24/69 (34.78%), Postives = 39/69 (56.52%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            L HG +++   E G TP+H+A ++G +NIV  LL+ + +  +P  +G+ P+H        DII  L  N
Sbjct:  390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRN 458

HSP 2 Score: 50.0618 bits (118), Expect = 3.817e-6
Identity = 22/66 (33.33%), Postives = 36/66 (54.55%), Query Frame = 2

Query:  476 HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            +G N+++  + G TP+H+A + G  N+V+ LL+   N     + G  P+H T    H  I+N L E
Sbjct:  689 NGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLE 754

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303117)

HSP 1 Score: 55.4546 bits (132), Expect = 8.062e-8
Identity = 24/69 (34.78%), Postives = 39/69 (56.52%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            L HG +++   E G TP+H+A ++G +NIV  LL+ + +  +P  +G+ P+H        DII  L  N
Sbjct:  390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRN 458

HSP 2 Score: 50.0618 bits (118), Expect = 3.780e-6
Identity = 22/66 (33.33%), Postives = 36/66 (54.55%), Query Frame = 2

Query:  476 HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            +G N+++  + G TP+H+A + G  N+V+ LL+   N     + G  P+H T    H  I+N L E
Sbjct:  689 NGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLE 754

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303113)

HSP 1 Score: 55.0694 bits (131), Expect = 8.445e-8
Identity = 24/69 (34.78%), Postives = 39/69 (56.52%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            L HG +++   E G TP+H+A ++G +NIV  LL+ + +  +P  +G+ P+H        DII  L  N
Sbjct:  390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRN 458

HSP 2 Score: 50.0618 bits (118), Expect = 3.957e-6
Identity = 22/66 (33.33%), Postives = 36/66 (54.55%), Query Frame = 2

Query:  476 HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            +G N+++  + G TP+H+A + G  N+V+ LL+   N     + G  P+H T    H  I+N L E
Sbjct:  689 NGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLE 754

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303111)

HSP 1 Score: 55.0694 bits (131), Expect = 8.584e-8
Identity = 24/69 (34.78%), Postives = 39/69 (56.52%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            L HG +++   E G TP+H+A ++G +NIV  LL+ + +  +P  +G+ P+H        DII  L  N
Sbjct:  397 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRN 465

HSP 2 Score: 50.0618 bits (118), Expect = 3.988e-6
Identity = 22/66 (33.33%), Postives = 36/66 (54.55%), Query Frame = 2

Query:  476 HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            +G N+++  + G TP+H+A + G  N+V+ LL+   N     + G  P+H T    H  I+N L E
Sbjct:  696 NGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLE 761

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303121)

HSP 1 Score: 55.0694 bits (131), Expect = 8.647e-8
Identity = 24/69 (34.78%), Postives = 39/69 (56.52%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            L HG +++   E G TP+H+A ++G +NIV  LL+ + +  +P  +G+ P+H        DII  L  N
Sbjct:  390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRN 458

HSP 2 Score: 50.0618 bits (118), Expect = 3.915e-6
Identity = 22/66 (33.33%), Postives = 36/66 (54.55%), Query Frame = 2

Query:  476 HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            +G N+++  + G TP+H+A + G  N+V+ LL+   N     + G  P+H T    H  I+N L E
Sbjct:  689 NGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLE 754

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:352910])

HSP 1 Score: 60.4622 bits (145), Expect = 1.905e-9
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  507 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 589

HSP 2 Score: 55.8398 bits (133), Expect = 6.952e-8
Identity = 62/228 (27.19%), Postives = 102/228 (44.74%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVN--VQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N N  VQN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  633 YTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 853

HSP 3 Score: 50.0618 bits (118), Expect = 3.563e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  981 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1022

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:352910])

HSP 1 Score: 60.4622 bits (145), Expect = 1.927e-9
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  518 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 600

HSP 2 Score: 55.4546 bits (132), Expect = 7.281e-8
Identity = 62/228 (27.19%), Postives = 102/228 (44.74%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVN--VQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N N  VQN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  644 YTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 864

HSP 3 Score: 50.0618 bits (118), Expect = 3.570e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  992 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1033

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:352910])

HSP 1 Score: 60.4622 bits (145), Expect = 2.012e-9
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  507 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 589

HSP 2 Score: 52.373 bits (124), Expect = 7.368e-7
Identity = 62/236 (26.27%), Postives = 102/236 (43.22%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVN--VQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS----------KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N N  VQN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+           G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  633 YTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTVRTEKCLKLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 861

HSP 3 Score: 50.0618 bits (118), Expect = 4.031e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  989 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1030

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ankrd52a (ankyrin repeat domain 52a [Source:NCBI gene;Acc:553206])

HSP 1 Score: 60.4622 bits (145), Expect = 2.432e-9
Identity = 34/104 (32.69%), Postives = 55/104 (52.88%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            L  A   G +E ++ LL+ G N++  ++  + PIH A YLGH+ +VKLL+    +    D +G  P+H      H D++ YL  N  +I E  N+ G +   +A
Sbjct:  144 LHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDE-PNAFGNTALHVA 246

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: ankrd52a (ankyrin repeat domain 52a [Source:NCBI gene;Acc:553206])

HSP 1 Score: 60.4622 bits (145), Expect = 2.439e-9
Identity = 34/104 (32.69%), Postives = 55/104 (52.88%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            L  A   G +E ++ LL+ G N++  ++  + PIH A YLGH+ +VKLL+    +    D +G  P+H      H D++ YL  N  +I E  N+ G +   +A
Sbjct:  144 LHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDE-PNAFGNTALHVA 246

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Source:NCBI gene;Acc:549762])

HSP 1 Score: 61.2326 bits (147), Expect = 1.227e-9
Identity = 28/89 (31.46%), Postives = 52/89 (58.43%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPD 685
            LF+A   G+ E++RKL++ +NVN ++  G+  TP+H A   G  ++V+ LL+   N +  D+ G +P+H      H ++++ L  +  D
Sbjct:   29 LFEACRNGDVERVRKLVNADNVNSRDTAGRKSTPLHFAAGFGRKDVVEHLLQSGANVHARDDGGLIPLHNACSFGHAEVVSLLLRHGAD 117

HSP 2 Score: 51.2174 bits (121), Expect = 1.968e-6
Identity = 31/84 (36.90%), Postives = 44/84 (52.38%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDL-PIHTTVDLKHYDIINYL 667
            L ++   G EEK+  LL   NVN     G+  TP+HLA     + IV+LLL+   + +  D KGDL P+H      HY++   L
Sbjct:  182 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELL 264

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Source:NCBI gene;Acc:549762])

HSP 1 Score: 60.8474 bits (146), Expect = 2.047e-9
Identity = 28/89 (31.46%), Postives = 52/89 (58.43%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPD 685
            LF+A   G+ E++RKL++ +NVN ++  G+  TP+H A   G  ++V+ LL+   N +  D+ G +P+H      H ++++ L  +  D
Sbjct:   29 LFEACRNGDVERVRKLVNADNVNSRDTAGRKSTPLHFAAGFGRKDVVEHLLQSGANVHARDDGGLIPLHNACSFGHAEVVSLLLRHGAD 117

HSP 2 Score: 50.8322 bits (120), Expect = 3.601e-6
Identity = 31/84 (36.90%), Postives = 44/84 (52.38%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDL-PIHTTVDLKHYDIINYL 667
            L ++   G EEK+  LL   NVN     G+  TP+HLA     + IV+LLL+   + +  D KGDL P+H      HY++   L
Sbjct:  182 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELL 264

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Source:NCBI gene;Acc:549762])

HSP 1 Score: 60.8474 bits (146), Expect = 2.082e-9
Identity = 28/89 (31.46%), Postives = 52/89 (58.43%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPD 685
            LF+A   G+ E++RKL++ +NVN ++  G+  TP+H A   G  ++V+ LL+   N +  D+ G +P+H      H ++++ L  +  D
Sbjct:   29 LFEACRNGDVERVRKLVNADNVNSRDTAGRKSTPLHFAAGFGRKDVVEHLLQSGANVHARDDGGLIPLHNACSFGHAEVVSLLLRHGAD 117

HSP 2 Score: 50.8322 bits (120), Expect = 3.501e-6
Identity = 31/84 (36.90%), Postives = 44/84 (52.38%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDL-PIHTTVDLKHYDIINYL 667
            L ++   G EEK+  LL   NVN     G+  TP+HLA     + IV+LLL+   + +  D KGDL P+H      HY++   L
Sbjct:  182 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELL 264

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100170182])

HSP 1 Score: 60.4622 bits (145), Expect = 3.028e-9
Identity = 30/83 (36.14%), Postives = 50/83 (60.24%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  DI+  L E   D+
Sbjct:  507 GDEGTVVEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKKLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589

HSP 2 Score: 50.0618 bits (118), Expect = 5.662e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  957 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 998

HSP 3 Score: 49.2914 bits (116), Expect = 8.750e-6
Identity = 33/108 (30.56%), Postives = 51/108 (47.22%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            L  A   G+  K+  LL  ++V+V  +  G T +  A   GH++I+KLLLK + +    D  GD  +H         ++  L     D L A+N + Q+   IA NK 
Sbjct:  435 LVKAAANGDVAKVEDLLKRQDVDVNGQCAGHTAMQAASQNGHVDILKLLLKHSVDVEAEDKDGDRAVHHAAFGDEGTVVEVLHRGGAD-LNARNKRRQTPLHIAVNKG 541

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100170182])

HSP 1 Score: 60.077 bits (144), Expect = 3.579e-9
Identity = 30/83 (36.14%), Postives = 50/83 (60.24%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  DI+  L E   D+
Sbjct:  519 GDEGTVVEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKKLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 601

HSP 2 Score: 50.0618 bits (118), Expect = 5.048e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  997 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1038

HSP 3 Score: 49.2914 bits (116), Expect = 9.868e-6
Identity = 33/108 (30.56%), Postives = 51/108 (47.22%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            L  A   G+  K+  LL  ++V+V  +  G T +  A   GH++I+KLLLK + +    D  GD  +H         ++  L     D L A+N + Q+   IA NK 
Sbjct:  447 LVKAAANGDVAKVEDLLKRQDVDVNGQCAGHTAMQAASQNGHVDILKLLLKHSVDVEAEDKDGDRAVHHAAFGDEGTVVEVLHRGGAD-LNARNKRRQTPLHIAVNKG 553

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Tnni3k (TNNI3 interacting kinase [Source:MGI Symbol;Acc:MGI:2443276])

HSP 1 Score: 63.1586 bits (152), Expect = 2.897e-10
Identity = 51/153 (33.33%), Postives = 69/153 (45.10%), Query Frame = 2

Query:  248 FINLQDKCRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI--YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
             ++L   C G  S IR   L G   S +T   F    + V KD+LE     LH    V        T+L  A   G  E +  LL HG NVNVQ+    TP+H+A Y GH  +  +LLKF  +  +    GD P+H       ++I+  L E 
Sbjct:   70 LLHLCCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEG 222

HSP 2 Score: 54.6842 bits (130), Expect = 1.528e-7
Identity = 38/111 (34.23%), Postives = 57/111 (51.35%), Query Frame = 2

Query:  383 HPETL---------VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFN-PNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            HPE +         VN+ +   +T L  A   G E+    LL  G +VNV  E G  P+HLA   G  NIVKLL++ N  +    DN+  +P+H      H++I++YL ++
Sbjct:  146 HPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQS 256

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Tnni3k (TNNI3 interacting kinase [Source:MGI Symbol;Acc:MGI:2443276])

HSP 1 Score: 63.1586 bits (152), Expect = 3.277e-10
Identity = 51/153 (33.33%), Postives = 69/153 (45.10%), Query Frame = 2

Query:  248 FINLQDKCRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI--YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
             ++L   C G  S IR   L G   S +T   F    + V KD+LE     LH    V        T+L  A   G  E +  LL HG NVNVQ+    TP+H+A Y GH  +  +LLKF  +  +    GD P+H       ++I+  L E 
Sbjct:   70 LLHLCCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEG 222

HSP 2 Score: 54.6842 bits (130), Expect = 1.480e-7
Identity = 38/111 (34.23%), Postives = 57/111 (51.35%), Query Frame = 2

Query:  383 HPETL---------VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFN-PNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            HPE +         VN+ +   +T L  A   G E+    LL  G +VNV  E G  P+HLA   G  NIVKLL++ N  +    DN+  +P+H      H++I++YL ++
Sbjct:  146 HPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQS 256

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Ankrd39 (ankyrin repeat domain 39 [Source:MGI Symbol;Acc:MGI:1914816])

HSP 1 Score: 57.3806 bits (137), Expect = 2.344e-9
Identity = 35/124 (28.23%), Postives = 58/124 (46.77%), Query Frame = 2

Query:  368 LEYYLHPETLVNIPEI--YTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            ++Y++   T  + P+   YT+L  A   G     + LL  G   + Q   G T +H A Y GH  I +LLL    N ++ DN G   +H   +  H DI + L ++ P +   ++ K +   D+
Sbjct:   47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLHKAAEKGHEDICSLLLQHSPALKAVRDRKARLACDL 170

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2443157])

HSP 1 Score: 58.9214 bits (141), Expect = 6.344e-9
Identity = 29/83 (34.94%), Postives = 49/83 (59.04%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH    ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  DI+  L E   D+
Sbjct:  142 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 224

HSP 2 Score: 53.9138 bits (128), Expect = 2.182e-7
Identity = 64/231 (27.71%), Postives = 106/231 (45.89%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVN--VQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE-------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTIS--MPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N N  +QN   QT +HLA    H  IV+LL++      I D  GD P+H    L+H+  ++ LR  +++ D+ +       +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     + +S  + S+   M  S + E + E   C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  268 YTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVSGQVGSRSPSM-ISNDSETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 490

HSP 3 Score: 50.0618 bits (118), Expect = 3.545e-6
Identity = 35/108 (32.41%), Postives = 50/108 (46.30%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            L  A   G+  K+  LL   +V+V  +  G T +  A   GH++I+KLLLK N +    D  GD  +H         +I  L     D L A+N + Q+   IA NK 
Sbjct:   70 LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD-LNARNKRRQTPLHIAVNKG 176

HSP 4 Score: 49.2914 bits (116), Expect = 7.654e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  592 IKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKA 633

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Cdkn2c (cyclin dependent kinase inhibitor 2C [Source:MGI Symbol;Acc:MGI:105388])

HSP 1 Score: 55.0694 bits (131), Expect = 1.094e-8
Identity = 29/91 (31.87%), Postives = 49/91 (53.85%), Query Frame = 2

Query:  464 RKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
            R LL G N N+++  G   IH A   G ++ V+ LL+F  +  I DN+G+LP+H      H  ++ +L ++    +  +N KG +  D+A 
Sbjct:   55 RLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLAR 145

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5GIG6|TNI3K_MOUSE (Serine/threonine-protein kinase TNNI3K OS=Mus musculus OX=10090 GN=Tnni3k PE=2 SV=4)

HSP 1 Score: 63.1586 bits (152), Expect = 2.292e-9
Identity = 51/153 (33.33%), Postives = 69/153 (45.10%), Query Frame = 2

Query:  248 FINLQDKCRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI--YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
             ++L   C G  S IR   L G   S +T   F    + V KD+LE     LH    V        T+L  A   G  E +  LL HG NVNVQ+    TP+H+A Y GH  +  +LLKF  +  +    GD P+H       ++I+  L E 
Sbjct:   70 LLHLCCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEG 222

HSP 2 Score: 54.6842 bits (130), Expect = 1.035e-6
Identity = 38/111 (34.23%), Postives = 57/111 (51.35%), Query Frame = 2

Query:  383 HPETL---------VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFN-PNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            HPE +         VN+ +   +T L  A   G E+    LL  G +VNV  E G  P+HLA   G  NIVKLL++ N  +    DN+  +P+H      H++I++YL ++
Sbjct:  146 HPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQS 256

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q59H18|TNI3K_HUMAN (Serine/threonine-protein kinase TNNI3K OS=Homo sapiens OX=9606 GN=TNNI3K PE=1 SV=3)

HSP 1 Score: 61.2326 bits (147), Expect = 7.891e-9
Identity = 50/147 (34.01%), Postives = 67/147 (45.58%), Query Frame = 2

Query:  269 CRGYSS-IRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI----YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            C G  S IR   L G   S +T   F+   + V KDN E     LH     +I ++     T+L  A   G  E    LL HG NVN+Q+    TP+H+A Y GH  + +LLLKF  +  +    GD P+H        +I   L E
Sbjct:   77 CGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 221

HSP 2 Score: 55.8398 bits (133), Expect = 3.915e-7
Identity = 36/98 (36.73%), Postives = 52/98 (53.06%), Query Frame = 2

Query:  398 VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            VNI +   +T L  A   G E+  R LL  G +VNV  E G  P+HLA   G +NI KLL++     +    DN+  +P+H      H+DI+ YL ++
Sbjct:  160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 257

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5RF15|TNI3K_PONAB (Serine/threonine-protein kinase TNNI3K OS=Pongo abelii OX=9601 GN=TNNI3K PE=2 SV=3)

HSP 1 Score: 60.8474 bits (146), Expect = 1.033e-8
Identity = 48/142 (33.80%), Postives = 65/142 (45.77%), Query Frame = 2

Query:  281 SSIRMNHLPG---SYVTVEHFSPTEVLVKKDNLEY---YLHPETLVNIPEI----YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            S IR   L G   S +T   F+   + V KDN E     LH     +I ++     T+L  A   G  E    LL HG NVN+Q+    TP+H+A Y GH  + +LLLKF  +  +    GD P+H        +I   L E
Sbjct:   82 SHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHGGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 221

HSP 2 Score: 56.9954 bits (136), Expect = 1.459e-7
Identity = 37/98 (37.76%), Postives = 52/98 (53.06%), Query Frame = 2

Query:  398 VNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            VNI +   +T L  A   G E+  R LL  G +VNV  E G  P+HLA   G +NI KLL++     +    DN+  +P+H      H+DI+ YL +N
Sbjct:  160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQN 257

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q804S5|MIB1_DANRE (E3 ubiquitin-protein ligase mib1 OS=Danio rerio OX=7955 GN=mib1 PE=1 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.438e-8
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  507 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 589

HSP 2 Score: 55.8398 bits (133), Expect = 5.248e-7
Identity = 62/228 (27.19%), Postives = 102/228 (44.74%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGENVN--VQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N N  VQN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  633 YTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 853

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9D2X0|ANR39_MOUSE (Ankyrin repeat domain-containing protein 39 OS=Mus musculus OX=10090 GN=Ankrd39 PE=1 SV=1)

HSP 1 Score: 57.3806 bits (137), Expect = 1.640e-8
Identity = 35/124 (28.23%), Postives = 58/124 (46.77%), Query Frame = 2

Query:  368 LEYYLHPETLVNIPEI--YTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            ++Y++   T  + P+   YT+L  A   G     + LL  G   + Q   G T +H A Y GH  I +LLL    N ++ DN G   +H   +  H DI + L ++ P +   ++ K +   D+
Sbjct:   47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLHKAAEKGHEDICSLLLQHSPALKAVRDRKARLACDL 170

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A2A2LPZ6 (ANK_REP_REGION domain-containing protein OS=Diploscapter pachys OX=2018661 GN=WR25_13157 PE=4 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 9.107e-12
Identity = 44/127 (34.65%), Postives = 73/127 (57.48%), Query Frame = 2

Query:  368 LEYYLH--PETLVNIPEI--YTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            ++Y++   P TL++  E   +T+LF AVT G  E  ++LLH G N N Q+   +TP H A   G + ++KLL ++N +F I + +GDLP H  +     D++ +L    P  L+A N +G++   +A
Sbjct:  222 IDYFMENAPRTLIDQRERAGHTALFYAVTYGHYEAAKRLLHYGANPNFQDHRLRTPSHCAAAKGQLRMLKLLKQYNASFEIQNYRGDLPFHEAIQTGSKDVVEWLLSLHPSSLDAANHEGRTALHLA 348

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A401NQ82 (ANK_REP_REGION domain-containing protein OS=Scyliorhinus torazame OX=75743 GN=scyTo_0011559 PE=4 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 2.338e-11
Identity = 37/113 (32.74%), Postives = 61/113 (53.98%), Query Frame = 2

Query:  401 NIPEI--YTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            N+P++  YT+L  A  +G+ E    LL  G N N Q + G TP+H A Y GH+ ++KLLL +     I D+ G  P+H   +  H +    L ++ P +  AK+ + ++  D+
Sbjct:   59 NVPDLSGYTALHYASRRGDYEVCEYLLRKGANSNAQTKGGATPLHRAAYCGHLAVLKLLLSYGAVPAITDDDGATPLHKAAERGHQEACEALLQHTPALRTAKDRRSRAPHDL 171

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A2A2JRZ3 (ANK_REP_REGION domain-containing protein OS=Diploscapter pachys OX=2018661 GN=WR25_07022 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 8.529e-11
Identity = 43/127 (33.86%), Postives = 71/127 (55.91%), Query Frame = 2

Query:  368 LEYYLH--PETLVNIPEI--YTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIA 733
            ++Y++   P  L++  E   +T+LF AVT G  E  ++LLH G N N Q+   +TP H A   G + ++KLL ++N +F   + +GDLP H  V     D++ +L    P  L+A N +G++   +A
Sbjct:  222 IDYFMENAPRALIDQRERAGHTALFYAVTYGHYEAAKRLLHYGANPNFQDHRLRTPSHCAAAKGQLRMLKLLKQYNASFETQNYRGDLPFHEAVQTGSKDVVEWLLSLHPSSLDAANHEGRTALHLA 348

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A429GPX4 (ANK_REP_REGION domain-containing protein OS=Candidatus Methanodesulfokores washburnensis OX=2478471 GN=D6D85_05465 PE=4 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 1.697e-10
Identity = 36/108 (33.33%), Postives = 62/108 (57.41%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            LFDA  +G+ +K+++LL+ G +VN ++E G TP+H A Y GH+N+VKLL+    +       G+ P+H        D++ +L +   D+  AK+  G +   +A +K 
Sbjct:   30 LFDAANRGDLKKVKRLLNEGADVNAKDEDGWTPLHWAAYYGHLNVVKLLVDRGADVNAKSKAGETPLHWAAANGRLDVVEFLVDRGADV-NAKSKAGWTPLHLAADKG 136

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: H3B7D3 (Ankyrin repeat domain 39 OS=Latimeria chalumnae OX=7897 GN=ANKRD39 PE=4 SV=1)

HSP 1 Score: 70.0922 bits (170), Expect = 1.972e-10
Identity = 33/89 (37.08%), Postives = 49/89 (55.06%), Query Frame = 2

Query:  470 LLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
            LL+G N N Q + G TP+H A Y GH NIV+LLL    N  I D  G  P+H   +  H+++   L E  P +   ++ KG+  +D+ +
Sbjct:   84 LLNGANSNAQTKGGATPLHRAAYCGHQNIVELLLSHGANPQITDEDGMSPLHKAAERGHWEVCAILLEKNPGLKTLQDKKGRRARDLVQ 172

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ankrd39 (ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE-081104-153])

HSP 1 Score: 57.7658 bits (138), Expect = 1.370e-9
Identity = 29/107 (27.10%), Postives = 50/107 (46.73%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLL--HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            YT+L    ++   + + +LL   G   N Q   G T +H A Y GH+ I++LLL    +  + D+ G   +H   +  H D+   L  N P +   K+ + +   D+
Sbjct:   55 YTALVTLCSRAGHQSVCELLLDQGARANSQTRGGATALHRAAYCGHLAIIQLLLTHRADPSLTDDDGSTSLHKAAEQGHVDVCELLVMNCPALRSMKDKRSRLPSDL 161

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:352910])

HSP 1 Score: 60.4622 bits (145), Expect = 1.557e-9
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  504 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 586

HSP 2 Score: 52.7582 bits (125), Expect = 4.472e-7
Identity = 59/227 (25.99%), Postives = 102/227 (44.93%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCR 1054
            YT+L  A      E    L+H    ++++QN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C+
Sbjct:  630 YTALHLAALNNHVEVAELLVHQGSASLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICK 849

HSP 3 Score: 50.447 bits (119), Expect = 2.814e-6
Identity = 34/113 (30.09%), Postives = 52/113 (46.02%), Query Frame = 2

Query:  410 EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            +I   L  A   G+  K+  +L   +V+V  +  G T +  A   GH++++KLLLK N +    D  GD  +H         +I  L     D L A+N + Q+   IA NK 
Sbjct:  427 DINEELVKAAANGDLAKVEDILKRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHNVDLEAEDKDGDRAVHHAAFGDEGSVIEVLHRGGAD-LNARNKRRQTPLHIAVNKG 538

HSP 4 Score: 50.0618 bits (118), Expect = 3.070e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  978 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1019

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:352910])

HSP 1 Score: 60.4622 bits (145), Expect = 1.604e-9
Identity = 29/83 (34.94%), Postives = 51/83 (61.45%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++LH  G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  507 GDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 589

HSP 2 Score: 52.7582 bits (125), Expect = 4.773e-7
Identity = 59/227 (25.99%), Postives = 102/227 (44.93%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCR 1054
            YT+L  A      E    L+H    ++++QN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  S  +++     +  S          + N+E + E   C +C D  + T+   CGH+  C  CS R+  C +C+
Sbjct:  633 YTALHLAALNNHVEVAELLVHQGSASLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNETLEE---CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICK 852

HSP 3 Score: 50.447 bits (119), Expect = 2.927e-6
Identity = 34/113 (30.09%), Postives = 52/113 (46.02%), Query Frame = 2

Query:  410 EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            +I   L  A   G+  K+  +L   +V+V  +  G T +  A   GH++++KLLLK N +    D  GD  +H         +I  L     D L A+N + Q+   IA NK 
Sbjct:  430 DINEELVKAAANGDLAKVEDILKRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHNVDLEAEDKDGDRAVHHAAFGDEGSVIEVLHRGGAD-LNARNKRRQTPLHIAVNKG 541

HSP 4 Score: 50.0618 bits (118), Expect = 3.424e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  957 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 998

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ankrd39 (ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE-081104-153])

HSP 1 Score: 56.9954 bits (136), Expect = 2.239e-9
Identity = 29/107 (27.10%), Postives = 50/107 (46.73%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLL--HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            YT+L    ++   + + +LL   G   N Q   G T +H A Y GH+ I++LLL    +  + D+ G   +H   +  H D+   L  N P +   K+ + +   D+
Sbjct:   61 YTALVTLCSRAGHQSVCELLLDQGARANSQTRGGATALHRAAYCGHLAIIQLLLTHRADPSLTDDDGSTSLHKAAEQGHVDVCELLVMNCPALRSMKDKRSRLPSDL 167

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: tnni3k (serine/threonine-protein kinase TNNI3K [Source:NCBI gene;Acc:103033588])

HSP 1 Score: 59.6918 bits (143), Expect = 3.117e-9
Identity = 33/86 (38.37%), Postives = 43/86 (50.00%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRE 673
            T+L  A   G  E +  LL HG  VN+Q+    TP+H+A Y GH  + KLLLKF  +  +    GD P+H         II  L E
Sbjct:  136 TALHVATIAGHLEAVDILLQHGAYVNIQDAVFFTPLHIAAYFGHEQVCKLLLKFGADVNVSGEVGDRPLHLAAAKGFLGIIRLLME 221

HSP 2 Score: 52.373 bits (124), Expect = 5.294e-7
Identity = 38/143 (26.57%), Postives = 65/143 (45.45%), Query Frame = 2

Query:  275 GYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETLVNIPE--IYTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLK--FNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            GY ++   H+        H    ++L++             VNI +   +T L  A   G E+  + LL  G +VNV  E G  P+HLA   G + I++LL++     +    DN+  +P+H      H DI+++L +   D+
Sbjct:  131 GYGALTALHVA---TIAGHLEAVDILLQHG---------AYVNIQDAVFFTPLHIAAYFGHEQVCKLLLKFGADVNVSGEVGDRPLHLAAAKGFLGIIRLLMEEGGKTDVNAQDNEDHVPLHFCARFGHQDIVHFLLQGNFDV 261

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ankrd39 (ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE-081104-153])

HSP 1 Score: 58.5362 bits (140), Expect = 1.827e-10
Identity = 34/106 (32.08%), Postives = 49/106 (46.23%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDI 730
            YT+L  A   G E   R LL HG  VN Q   G T +  A Y GH  IV LL K   +  + D+ G   +H   +  H  +   L +  PD+ +  ++K +   D+
Sbjct:   65 YTALHYASRNGHEAVCRALLSHGALVNAQTPGGATALSRAAYCGHGTIVSLLFKHGADCRLRDSDGMTALHKVAEGGHLSVCKLLVQQQPDLKDIVDNKCRKACDL 170

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003964.1 (pep scaffold:Pmarinus_7.0:GL481009:348:11102:1 gene:ENSPMAG00000003629.1 transcript:ENSPMAT00000003964.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 5.954e-9
Identity = 33/89 (37.08%), Postives = 50/89 (56.18%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLL-KFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENV 679
            T+L  AV+ G ++ +R LL  G +VNVQ++ G T +  A   GH++IV+LLL +   N  I DN G   +   ++  H DI   L  +V
Sbjct:  585 TALMLAVSHGRKDMVRALLACGADVNVQDDDGSTALMCASEHGHVDIVRLLLAQAGCNAAIADNDGSTALSIALEAGHNDIAVLLYAHV 673

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003902.1 (pep scaffold:Pmarinus_7.0:GL487589:3324:8008:1 gene:ENSPMAG00000003575.1 transcript:ENSPMAT00000003902.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.0618 bits (118), Expect = 6.031e-8
Identity = 28/83 (33.73%), Postives = 43/83 (51.81%), Query Frame = 2

Query:  410 EIYTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDI 655
            E +T L  AV+    + ++ LL  G ++N Q+  G+TP+ LA YLG +     LL+      +PD  G LP+H      H D+
Sbjct:   41 EGFTPLMHAVSGRRLDTVKLLLKMGTSINTQDACGRTPLSLAAYLGWLEGCLSLLRNGARQNMPDKNGRLPLHAAT--AHGDV 121

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009608.1 (pep scaffold:Pmarinus_7.0:GL477242:23155:61557:-1 gene:ENSPMAG00000008655.1 transcript:ENSPMAT00000009608.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 7.128e-8
Identity = 30/83 (36.14%), Postives = 42/83 (50.60%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYL 667
            L +A   G EEKL  LL   NVN     G+  TP+HLA     + IV+LLL+   + +  D  G +P+H      HY++   L
Sbjct:  304 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 386

HSP 2 Score: 50.8322 bits (120), Expect = 4.675e-7
Identity = 25/83 (30.12%), Postives = 47/83 (56.63%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYL 667
            LF+A   G+  ++++L+   NVN ++  G+  TP+H A   G  ++V+ LL+   N +  D+ G +P+H      H +++N L
Sbjct:  151 LFEACRNGDVGRVKRLVSPLNVNARDTTGRKSTPLHFAAGFGRKDVVEHLLQNGANVHARDDGGLIPLHNACSFGHAEVVNLL 233

HSP 3 Score: 50.447 bits (119), Expect = 6.122e-7
Identity = 27/80 (33.75%), Postives = 43/80 (53.75%), Query Frame = 2

Query:  422 SLFDAVTKGEEEKLRKLLHGENVNVQNEFGQ--TPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDI 655
            +L DA  KG   +++KL  GENVN ++  G+  TP+HLA    ++ + + LL+   +    D  G +P+H      H DI
Sbjct:  772 ALLDAAKKGCLARVQKLCSGENVNCRDSQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 851

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010488.1 (pep scaffold:Pmarinus_7.0:GL501102:192066:206968:-1 gene:ENSPMAG00000009500.1 transcript:ENSPMAT00000010488.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.9878 bits (123), Expect = 1.352e-7
Identity = 29/84 (34.52%), Postives = 42/84 (50.00%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYL 667
            T L  A  KG+ + +  LL +G N N+++  G TP+H AC  GH  +V+LLL        P  + D P+H  V   H  +   L
Sbjct:  384 TPLHVAAIKGDIDGVEHLLENGANPNIKDNAGWTPLHEACNHGHARVVELLLDHGAFINAPGYENDSPLHDAVSNGHTHVAGLL 467

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Match: HOS4 (Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate [Source:SGD;Acc:S000001374])

HSP 1 Score: 46.9802 bits (110), Expect = 4.091e-6
Identity = 33/102 (32.35%), Postives = 54/102 (52.94%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNK--GDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKG 712
            T L  A  KG+ + ++K++   G ++N Q+  G T +H A   GHI IV+LL++   +  I   +  GD P+       H D++ YL +N  D    +N+KG
Sbjct:  332 TRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPT-IRNAKG 432

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO42168 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S234])

HSP 1 Score: 56.225 bits (134), Expect = 2.417e-10
Identity = 29/83 (34.94%), Postives = 45/83 (54.22%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINY 664
            T L  A T+G  E  + L+ +G NVN  N FG+TP+H AC    +  V +L++   +F + DN G   +H   +  H D++ Y
Sbjct:    3 TPLHRAATRGNIEACKLLIQYGANVNKVNGFGETPLHYACQAASLRFVNVLVENGADFNVLDNGGRSFLHIAAEHGHIDLLEY 85

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO43690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXV8])

HSP 1 Score: 57.3806 bits (137), Expect = 2.120e-9
Identity = 34/105 (32.38%), Postives = 58/105 (55.24%), Query Frame = 2

Query:  425 LFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
               AV+ G+ ++++KLL  G ++N QN  G T +H AC   + ++VK+L+    +  + DN+G   +H        +I  YL EN  D+  A N++G+   D+AE
Sbjct:   53 FLSAVSSGDVDEVKKLLAKGADINYQNVDGLTALHQACIDENFDLVKVLVDKGASMDVRDNEGWTSLHAAASCGSVEIAKYLIENGADV-AAVNNEGELPLDLAE 156

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO36611 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SI88])

HSP 1 Score: 51.9878 bits (123), Expect = 7.370e-9
Identity = 29/80 (36.25%), Postives = 45/80 (56.25%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDI 655
            T+L  A  KG+ ++LR L+  G NVN+++  G TP+H AC  GHI+IV+ L+K       P  +   P+H  +   H  +
Sbjct:   11 TALHLASIKGDVDELRSLIKAGANVNIKDYAGWTPLHEACNFGHISIVEELIKAGACVNTPGYESITPLHDAIINNHVQV 90

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO35810 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKC0])

HSP 1 Score: 51.6026 bits (122), Expect = 1.226e-7
Identity = 30/108 (27.78%), Postives = 53/108 (49.07%), Query Frame = 2

Query:  422 SLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            + FD   +G  +++  L+  +N+N  +E G + +H AC  GH  +V  L+K N +  I D+ G  PIH     +   I+  L +    +   K+  G   +D  +NK+
Sbjct:  120 TAFDWCKEGNVKRMSSLISKKNINSPDEQGMSLLHWACDRGHDCVVDFLIKNNADVNITDSDGQTPIHYAATCEFTSIVQQLLD-AHALTNIKDVDGCLPEDATDNKS 226

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO44907 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUH8])

HSP 1 Score: 47.3654 bits (111), Expect = 1.866e-7
Identity = 22/64 (34.38%), Postives = 36/64 (56.25%), Query Frame = 2

Query:  485 NVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            N+N QN+ G +P+H     G ++ VKLL+ F  +  +P+  G  P+H    L + D++ YL  N
Sbjct:    1 NINTQNKAGDSPLHQCIKDGKLDSVKLLVDFGADITLPNRDGWSPMHVATFLGYRDMMLYLLMN 64

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: cdkn2d (cyclin dependent kinase inhibitor 2D [Source:NCBI gene;Acc:101155252])

HSP 1 Score: 58.151 bits (139), Expect = 8.056e-10
Identity = 37/125 (29.60%), Postives = 61/125 (48.80%), Query Frame = 2

Query:  371 EYYLHPETLVNIPEIYTSLFDAVTKGEEEKLRKLLH-GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYL--RENVPDILEAKNSKGQSVQDIAE 736
            E  +HP+T     E   +    +  G  +    LL  G + NVQ++ G  P+H A   G ++ +++L++   +  IPD  G LPIH  +   H D++ +L  R N    L+  N  GQ+  D+A 
Sbjct:   30 ECRVHPDTR---NEFGRTALQVMMMGNSKIASLLLEKGADANVQDKHGIAPVHDAARTGFLDTLQVLVENGASVNIPDQNGALPIHIAIWEGHRDVVQFLAPRSN----LKHANQSGQTAIDVAR 147

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101158637])

HSP 1 Score: 57.7658 bits (138), Expect = 1.376e-8
Identity = 28/83 (33.73%), Postives = 50/83 (60.24%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++L   G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  508 GDEGSVIEVLQRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 590

HSP 2 Score: 50.8322 bits (120), Expect = 1.887e-6
Identity = 34/113 (30.09%), Postives = 53/113 (46.90%), Query Frame = 2

Query:  410 EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            +I   L  A   G+  K+  +L   +V+V  +  G T +  A   GH++++KLLLK N +    D  GD  +H         +I  L+    D L A+N + Q+   IA NK 
Sbjct:  431 DINEELVKAAANGDLAKVEDILKRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHNVDLEAEDKDGDRAVHHAAFGDEGSVIEVLQRGGAD-LNARNKRRQTPLHIAVNKG 542

HSP 3 Score: 50.0618 bits (118), Expect = 3.021e-6
Identity = 63/234 (26.92%), Postives = 106/234 (45.30%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGEN--VNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR--ENVPDILE------AKNS--KGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESM-----EPSTLQTISM-PSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N  +++QN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR  +++ D+ +      +KN+   G   Q  AE K+   +   +  N   +   +K+ Q  L   P  +  +++     E S+ Q  +  PS    ME+ E          C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  634 YTALHLAALNNHVEVAELLVHQGNASLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQG-AEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPNLCKALAKCHKEKSSGQVGTRSPSLNSNMESLEE---------CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 854

HSP 4 Score: 50.0618 bits (118), Expect = 3.155e-6
Identity = 19/42 (45.24%), Postives = 25/42 (59.52%), Query Frame = 2

Query:  935 IPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKV 1060
            I E+  C +C DR+K  I  CGH  C+ C  R+  CP+CRK 
Sbjct:  971 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKA 1012

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: mib1 (mindbomb E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101158637])

HSP 1 Score: 57.3806 bits (137), Expect = 1.524e-8
Identity = 28/83 (33.73%), Postives = 50/83 (60.24%), Query Frame = 2

Query:  446 GEEEKLRKLLH--GENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDI 688
            G+E  + ++L   G ++N +N+  QTP+H+A   GH+ +VK LL F  +  + D++GD P+H  +  K  D+++ L E   D+
Sbjct:  508 GDEGSVIEVLQRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDMLSVLLEAGADV 590

HSP 2 Score: 51.2174 bits (121), Expect = 1.563e-6
Identity = 34/113 (30.09%), Postives = 53/113 (46.90%), Query Frame = 2

Query:  410 EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNE-FGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKN 745
            +I   L  A   G+  K+  +L   +V+V  +  G T +  A   GH++++KLLLK N +    D  GD  +H         +I  L+    D L A+N + Q+   IA NK 
Sbjct:  431 DINEELVKAAANGDLAKVEDILKRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHNVDLEAEDKDGDRAVHHAAFGDEGSVIEVLQRGGAD-LNARNKRRQTPLHIAVNKG 542

HSP 3 Score: 50.447 bits (119), Expect = 2.977e-6
Identity = 61/233 (26.18%), Postives = 103/233 (44.21%), Query Frame = 2

Query:  416 YTSLFDAVTKGEEEKLRKLLHGEN--VNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLR-----ENVPDILEAKNSKGQSVQDI----AENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESM-----EPSTLQTISM-PSKQYQMEASENHEYIPEELTCAICKDRMKTTILE-CGHMF-CRECSRRLPLCPMCRK 1057
            YT+L  A      E    L+H  N  +++QN   QT +HLA    H  IV+LL++      + D  GD P+H    L+H+  ++ LR     ++V  +   + SK   +  +    AE K+   +   +  N   +   +K+ Q  L   P  +  +++     E S+ Q  +  PS    ME+ E          C +C D  + T+   CGH+  C  CS R+  C +C++
Sbjct:  634 YTALHLAALNNHVEVAELLVHQGNASLDIQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQDKDGDTPLHEA--LRHH-TLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLTIRNKKGQSPLDLCPDPNLCKALAKCHKEKSSGQVGTRSPSLNSNMESLEE---------CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKE 854

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: tnni3k (serine/threonine-protein kinase TNNI3K [Source:NCBI gene;Acc:101167026])

HSP 1 Score: 57.3806 bits (137), Expect = 1.619e-8
Identity = 33/84 (39.29%), Postives = 41/84 (48.81%), Query Frame = 2

Query:  419 TSLFDAVTKGEEEKLRKLL-HGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYL 667
            T+L  A   G  E    LL HG NVNVQ+    TP+H+A Y GH  + KLLLKF  +       GD P+H         I+  L
Sbjct:  136 TALHVATLAGHHETADILLQHGANVNVQDAVFFTPLHIASYKGHEQVTKLLLKFGADVNASGEVGDRPLHLAAAKGFLAIVKLL 219

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: ppp1r12a (protein phosphatase 1 regulatory subunit 12A [Source:NCBI gene;Acc:101161524])

HSP 1 Score: 57.3806 bits (137), Expect = 1.710e-8
Identity = 34/102 (33.33%), Postives = 54/102 (52.94%), Query Frame = 2

Query:  434 AVTKGE-EEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAE 736
            A + G+ EE LR L  G ++N  N  G T +H AC   ++++V  L++   +   PDN+G +P+H      + DI  YL      +    NS+G++  DIAE
Sbjct:   47 ACSSGDTEEVLRMLDRGADINYANVDGLTALHQACIDDNVDMVTFLVEHGASVNQPDNEGWIPLHAAASCGYLDIAEYLISQGASV-GVVNSEGETPLDIAE 147

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000045407.1 (SMESG000045407.1)

HSP 1 Score: 568.54 bits (1464), Expect = 0.000e+0
Identity = 295/332 (88.86%), Postives = 296/332 (89.16%), Query Frame = 2

Query:  182 MIRNRKHFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETLVNIPEIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQP-------------------------------ILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK 1084
            M RNR+HFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETL    EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQLNNIILINLQTIPFPSKQCQP                               ILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK
Sbjct:    1 MKRNRRHFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETL----EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQLNNIILINLQTIPFPSKQCQPILVREPQNSENESMEPSTLRTLSMPSKECQMILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK 328

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000045407.1 (SMESG000045407.1)

HSP 1 Score: 436.802 bits (1122), Expect = 2.214e-154
Identity = 228/260 (87.69%), Postives = 229/260 (88.08%), Query Frame = 2

Query:  398 VNIPEIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQP-------------------------------ILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK 1084
            +NIPEIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQLNNIILINLQTIPFPSKQCQP                               ILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK
Sbjct:   19 LNIPEIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQLNNIILINLQTIPFPSKQCQPILVREPQNSENESMEPSTLRTLSMPSKECQMILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAELK 278

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000020728.1 (SMESG000020728.1)

HSP 1 Score: 140.584 bits (353), Expect = 4.458e-37
Identity = 102/337 (30.27%), Postives = 161/337 (47.77%), Query Frame = 2

Query:  197 KHFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETL------VNIPEIYTS---LFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQ-------------PILVREPQNSENES--------------MEP--STLQTISMPS------------KQYQMEASENHEYIPEELTCAICKD-RMKTTILECGHMFCRECSRRLPLCPMCR 1054
            K F  G+ L+V S++      Q  C GYS +RM  L G  VTV+H+S   V V+K+   Y LHP+ L       N+P+I  +    F A+   +E+KL +++  + +NVQN  G+TP++LAC LG + +VKLL+ F  +  + DN G+ PIH   +  H DI+ Y+ +  P+ +  KN  G S+ +IA+ KN+ +L   +L     I   ++  Q             P  +    + EN                M+P      TI +PS              Y M ++      P E  C IC+D  + T  ++CGH+ C  C+ R+  C +C+
Sbjct:  157 KTFKVGDMLRVSSNEKLIQEKQQYCGGYSKMRMRDLIGKIVTVKHYSVKCVKVEKEGKYYDLHPDILDYPVDKENLPKISENSILYFTAIADNDEDKLFQVIDKDTLNVQNNSGKTPVNLACCLGKLEMVKLLVDFGADLNVADNSGNYPIHNCANKGHVDILTYILQRFPEQINKKNQNGLSLLNIAKQKNNHRLETFLLA--SNIDSSTRISQSVTNSLEISLFSPPTTITRTNDDENSEFPTRYPAITISSSLMDPPRDEFDTIEVPSIPINSSSMANSSNLYTMNST------PVENECMICRDGHLNTAFVQCGHLACNVCADRIFRCHICQ 485

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000020728.1 (SMESG000020728.1)

HSP 1 Score: 137.117 bits (344), Expect = 1.090e-35
Identity = 101/341 (29.62%), Postives = 161/341 (47.21%), Query Frame = 2

Query:  197 KHFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEHFSPTEVLVKKDNLEYYLHPETL------VNIPEIYTSL-------FDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQ-------------PILVREPQNSENES--------------MEP--STLQTISMPS------------KQYQMEASENHEYIPEELTCAICKD-RMKTTILECGHMFCRECSRRLPLCPMCR 1054
            K F  G+ L+V S++      Q  C GYS +RM  L G  VTV+H+S   V V+K+   Y LHP+ L       N+P+   ++       F A+   +E+KL +++  + +NVQN  G+TP++LAC LG + +VKLL+ F  +  + DN G+ PIH   +  H DI+ Y+ +  P+ +  KN  G S+ +IA+ KN+ +L   +L     I   ++  Q             P  +    + EN                M+P      TI +PS              Y M ++      P E  C IC+D  + T  ++CGH+ C  C+ R+  C +C+
Sbjct:  157 KTFKVGDMLRVSSNEKLIQEKQQYCGGYSKMRMRDLIGKIVTVKHYSVKCVKVEKEGKYYDLHPDILDYPVDKENLPKKEPAVSENSILYFTAIADNDEDKLFQVIDKDTLNVQNNSGKTPVNLACCLGKLEMVKLLVDFGADLNVADNSGNYPIHNCANKGHVDILTYILQRFPEQINKKNQNGLSLLNIAKQKNNHRLETFLLA--SNIDSSTRISQSVTNSLEISLFSPPTTITRTNDDENSEFPTRYPAITISSSLMDPPRDEFDTIEVPSIPINSSSMANSSNLYTMNST------PVENECMICRDGHLNTAFVQCGHLACNVCADRIFRCHICQ 489

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000021295.1 (SMESG000021295.1)

HSP 1 Score: 84.3445 bits (207), Expect = 9.786e-18
Identity = 61/208 (29.33%), Postives = 98/208 (47.12%), Query Frame = 2

Query:  434 AVTKGEEEKLRKLLHGE-NVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQXXXXXXXXXQTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHEYIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCR 1054
            A   G  + L+ LL        ++++   PIH AC  GH+ IV++L++ N NF   + +   PIH      H DI+ +L  N  + LE ++  G++  D+A   N+E   ++IL  ++       + +   V  P+        PST + + +  K          E  PE   C IC DR    +L CGH+FC  C +R  +CP+CR
Sbjct:  175 ACVYGHVDILKLLLENNCTTETEDKYKTRPIHYACKTGHVEIVRILVENNCNFESQNIEKRRPIHYACKSGHVDIVKFLIHNKCN-LEVEDIDGKTPLDLALENNNEICVDMILTEIEARKKKISEMRQAFVDAPRPG------PSTKERMKVTVKARI-------ETKPERNICKICYDREVDCVLSCGHVFCMLCGKRFSICPVCR 368

HSP 2 Score: 53.9138 bits (128), Expect = 8.399e-8
Identity = 33/105 (31.43%), Postives = 49/105 (46.67%), Query Frame = 2

Query:  368 LEYYLHPETLVNIP--EIYTSLFDAVTKGEEEKLRKLLHGENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTTVDLKHYDIINYLREN 676
            + Y    E++ NIP  E +  LFD  ++          + E+++        PIH+AC+ GH NIVKL++  + N    D     PIH      H DI+  L EN
Sbjct:   96 IAYRCDLESIANIPTDENFEKLFDIDSE----------NSESISTMKTVQTRPIHIACWKGHCNIVKLMIDNDCNLQTNDKDNWKPIHVACVYGHVDILKLLLEN 190

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ANKRD2	8.301e-10	34.58	ankyrin repeat domain 2 [Source:HGNC Symbol;Acc:HG...	[more]
ANKRD2	9.386e-10	34.58	ankyrin repeat domain 2 [Source:HGNC Symbol;Acc:HG...	[more]
FPGT-TNNI3K	1.124e-9	34.01	FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HG...	[more]
FPGT-TNNI3K	1.291e-9	34.01	FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HG...	[more]
FPGT-TNNI3K	1.620e-9	34.01	FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HG...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nphp-2	2.516e-9	32.71	NePHronoPhthisis (Human kidney disease) homolog [...	[more]
nphp-2	2.700e-9	32.71	NePHronoPhthisis (Human kidney disease) homolog [...	[more]
trp-4	3.734e-6	28.04	TRP (Transient receptor potential) channel family ...	[more]
F40G9.17	3.892e-6	30.17	pep chromosome:WBcel235:III:194460:210063:1 gene:W...	[more]
F40G9.17	3.892e-6	30.17	pep chromosome:WBcel235:III:194462:200328:1 gene:W...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ank2	7.933e-8	34.78	gene:FBgn0261788 transcript:FBtr0303123	[more]
Ank2	8.062e-8	34.78	gene:FBgn0261788 transcript:FBtr0303117	[more]
Ank2	8.445e-8	34.78	gene:FBgn0261788 transcript:FBtr0303113	[more]
Ank2	8.584e-8	34.78	gene:FBgn0261788 transcript:FBtr0303111	[more]
Ank2	8.647e-8	34.78	gene:FBgn0261788 transcript:FBtr0303121	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mib1	1.905e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
mib1	1.927e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
mib1	2.012e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
ankrd52a	2.432e-9	32.69	ankyrin repeat domain 52a [Source:NCBI gene;Acc:55...	[more]
ankrd52a	2.439e-9	32.69	ankyrin repeat domain 52a [Source:NCBI gene;Acc:55...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tnks2	1.227e-9	31.46	tankyrase, TRF1-interacting ankyrin-related ADP-ri...	[more]
tnks2	2.047e-9	31.46	tankyrase, TRF1-interacting ankyrin-related ADP-ri...	[more]
tnks2	2.082e-9	31.46	tankyrase, TRF1-interacting ankyrin-related ADP-ri...	[more]
mib1	3.028e-9	36.14	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
mib1	3.579e-9	36.14	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tnni3k	2.897e-10	33.33	TNNI3 interacting kinase [Source:MGI Symbol;Acc:MG...	[more]
Tnni3k	3.277e-10	33.33	TNNI3 interacting kinase [Source:MGI Symbol;Acc:MG...	[more]
Ankrd39	2.344e-9	28.23	ankyrin repeat domain 39 [Source:MGI Symbol;Acc:MG...	[more]
Mib1	6.344e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:MGI...	[more]
Cdkn2c	1.094e-8	31.87	cyclin dependent kinase inhibitor 2C [Source:MGI S...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5GIG6\|TNI3K_MOUSE	2.292e-9	33.33	Serine/threonine-protein kinase TNNI3K OS=Mus musc...	[more]
sp\|Q59H18\|TNI3K_HUMAN	7.891e-9	34.01	Serine/threonine-protein kinase TNNI3K OS=Homo sap...	[more]
sp\|Q5RF15\|TNI3K_PONAB	1.033e-8	33.80	Serine/threonine-protein kinase TNNI3K OS=Pongo ab...	[more]
sp\|Q804S5\|MIB1_DANRE	1.438e-8	34.94	E3 ubiquitin-protein ligase mib1 OS=Danio rerio OX...	[more]
sp\|Q9D2X0\|ANR39_MOUSE	1.640e-8	28.23	Ankyrin repeat domain-containing protein 39 OS=Mus...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2A2LPZ6	9.107e-12	34.65	ANK_REP_REGION domain-containing protein OS=Diplos...	[more]
A0A401NQ82	2.338e-11	32.74	ANK_REP_REGION domain-containing protein OS=Scylio...	[more]
A0A2A2JRZ3	8.529e-11	33.86	ANK_REP_REGION domain-containing protein OS=Diplos...	[more]
A0A429GPX4	1.697e-10	33.33	ANK_REP_REGION domain-containing protein OS=Candid...	[more]
H3B7D3	1.972e-10	37.08	Ankyrin repeat domain 39 OS=Latimeria chalumnae OX...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ankrd39	1.370e-9	27.10	ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE...	[more]
mib1	1.557e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
mib1	1.604e-9	34.94	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
ankrd39	2.239e-9	27.10	ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE...	[more]
tnni3k	3.117e-9	38.37	serine/threonine-protein kinase TNNI3K [Source:NCB...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ankrd39	1.827e-10	32.08	ankyrin repeat domain 39 [Source:ZFIN;Acc:ZDB-GENE...	[more]
ENSPMAT00000003964.1	5.954e-9	37.08	pep scaffold:Pmarinus_7.0:GL481009:348:11102:1 gen...	[more]
ENSPMAT00000003902.1	6.031e-8	33.73	pep scaffold:Pmarinus_7.0:GL487589:3324:8008:1 gen...	[more]
ENSPMAT00000009608.1	7.128e-8	36.14	pep scaffold:Pmarinus_7.0:GL477242:23155:61557:-1 ...	[more]
ENSPMAT00000010488.1	1.352e-7	34.52	pep scaffold:Pmarinus_7.0:GL501102:192066:206968:-...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
HOS4	4.091e-6	32.35	Subunit of the Set3 complex; complex is a meiotic-...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO42168	2.417e-10	34.94	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43690	2.120e-9	32.38	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36611	7.370e-9	36.25	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35810	1.226e-7	27.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44907	1.866e-7	34.38	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdkn2d	8.056e-10	29.60	cyclin dependent kinase inhibitor 2D [Source:NCBI ...	[more]
mib1	1.376e-8	33.73	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
mib1	1.524e-8	33.73	mindbomb E3 ubiquitin protein ligase 1 [Source:NCB...	[more]
tnni3k	1.619e-8	39.29	serine/threonine-protein kinase TNNI3K [Source:NCB...	[more]
ppp1r12a	1.710e-8	33.33	protein phosphatase 1 regulatory subunit 12A [Sour...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000045407.1	0.000e+0	88.86	SMESG000045407.1	[more]
SMESG000045407.1	2.214e-154	87.69	SMESG000045407.1	[more]
SMESG000020728.1	4.458e-37	30.27	SMESG000020728.1	[more]
SMESG000020728.1	1.090e-35	29.62	SMESG000020728.1	[more]
SMESG000021295.1	9.786e-18	29.33	SMESG000021295.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30014025 ID=SMED30014025|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1170bp
TTGTTGAATGCTAAACTAAAAATTGAATGTCCATTATGAATGGCTGGCAC
TTTAAGCAGCACAATCCGTGTGCAGTTTTATTGATTGTGCACAAATGCGT
CGATATCATTCAATGTGCACCTTCAGCATTTGATAGAATTGCAGCCTGAT
AAATTATTTAATTTTTATTCGAAAAAATTTCATGATACGAAATCGAAAAC
ATTTTGTCAACGGCGAAAAACTAAAAGTGATTTCAGATAAAGATAAGTTC
ATAAATTTACAAGATAAATGCAGAGGATATTCGAGTATCCGAATGAACCA
TCTTCCAGGATCCTATGTCACAGTGGAACATTTTTCGCCAACAGAAGTCC
TGGTGAAAAAAGATAATTTAGAATATTATTTGCATCCCGAGACATTAGTA
AATATTCCAGAAATATACACAAGTTTATTTGATGCTGTAACAAAAGGAGA
AGAGGAGAAATTGCGGAAACTTTTGCATGGCGAAAATGTAAATGTACAAA
ATGAATTCGGGCAAACACCAATCCACCTGGCTTGCTATTTGGGACATATA
AACATTGTTAAATTACTATTAAAATTTAATCCCAATTTCTACATCCCTGA
TAACAAAGGAGATTTGCCCATTCACACAACTGTCGATCTAAAACATTACG
ATATCATAAATTACCTCAGAGAAAATGTCCCGGATATTTTGGAAGCCAAA
AATTCTAAAGGACAATCTGTGCAAGACATTGCTGAAAATAAGAATGATGA
ACAATTAAACAATATAATATTAATAAATTTACAAACCATTCCATTTCCAT
CAAAACAGTGTCAACCGATCTTGGTTAGAGAGCCGCAGAATTCCGAAAAC
GAATCAATGGAGCCTTCTACGTTGCAAACAATTTCAATGCCCTCAAAACA
GTATCAAATGGAAGCTTCAGAAAATCATGAATATATCCCTGAGGAATTAA
CCTGCGCAATTTGTAAAGACAGAATGAAAACCACGATTTTGGAATGTGGT
CATATGTTTTGTCGCGAGTGTTCCAGGAGGCTACCCTTATGTCCTATGTG
TAGGAAGGTAACCAAAGTTTTCGCGGAATTAAAATGACATTGTTTTGATT
AGTCACTTCTGTATTTTTAACTAGTTATGTGAAAATTTATAAGGTTTCCT
TTCACAAACAGCAAGATTTG

protein sequence of SMED30014025-orf-1

>SMED30014025-orf-1 ID=SMED30014025-orf-1|Name=SMED30014025-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=302bp
MIRNRKHFVNGEKLKVISDKDKFINLQDKCRGYSSIRMNHLPGSYVTVEH
FSPTEVLVKKDNLEYYLHPETLVNIPEIYTSLFDAVTKGEEEKLRKLLHG
ENVNVQNEFGQTPIHLACYLGHINIVKLLLKFNPNFYIPDNKGDLPIHTT
VDLKHYDIINYLRENVPDILEAKNSKGQSVQDIAENKNDEQLNNIILINL
QTIPFPSKQCQPILVREPQNSENESMEPSTLQTISMPSKQYQMEASENHE
YIPEELTCAICKDRMKTTILECGHMFCRECSRRLPLCPMCRKVTKVFAEL
K*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036770	Ankyrin_rpt-contain_sf
IPR028320	iASPP
IPR001841	Znf_RING
IPR002110	Ankyrin_rpt
IPR013083	Znf_RING/FYVE/PHD
IPR020683	Ankyrin_rpt-contain_dom

Vocabulary: **molecular function**
Term	Definition
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0003674	molecular_function

Vocabulary: **biological process**
Term	Definition
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008150	biological_process

Vocabulary: **cellular component**
Term	Definition
GO:0005575	cellular_component

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002110	Ankyrin repeat	SMART	SM00248	ANK_2a	coord: 109..138 e-value: 1.3E-5 score: 34.6 coord: 142..171 e-value: 52.0 score: 12.7 coord: 77..105 e-value: 2300.0 score: 2.4
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 109..141 score: 11.808
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 258..290 e-value: 2.9E-7 score: 40.1
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 258..291 score: 13.035
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 233..298 e-value: 5.5E-13 score: 50.1
IPR020683	Ankyrin repeat-containing domain	PFAM	PF12796	Ank_2	coord: 82..165 e-value: 4.9E-13 score: 49.5
IPR020683	Ankyrin repeat-containing domain	PROSITE	PS50297	ANK_REP_REGION	coord: 97..197 score: 19.173
IPR036770	Ankyrin repeat-containing domain superfamily	GENE3D	G3DSA:1.25.40.20		coord: 76..201 e-value: 2.2E-23 score: 84.3
IPR036770	Ankyrin repeat-containing domain superfamily	SUPERFAMILY	SSF48403	Ankyrin repeat	coord: 78..197
None	No IPR available	PFAM	PF13920	zf-C3HC4_3	coord: 255..293 e-value: 1.0E-8 score: 34.9
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 248..295
IPR028320	RelA-associated inhibitor	PANTHER	PTHR24164	FAMILY NOT NAMED	coord: 82..188