MFS domain-containing protein

Overview
NameMFS domain-containing protein
Smed IDSMED30014006
Length (bp)660
Neoblast Clusters

Zeng et. al., 2018




 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30014006

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30014006h1SMcG0004953 SmedASXL_078659SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
pigment cellSMED30014006h1SMcG0004953 SmedASXL_070184SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
pigment cellSMED30014006h1SMcG0004953 SmedASXL_069607SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30014006h1SMcG0004953 Contig48725uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014006h1SMcG0004953 Contig48725newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014006h1SMcG0004953 Contig13260newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30014006h1SMcG0004953 Contig13260uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30014006h1SMcG0004953 dd_Smed_v4_3455_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30014006h1SMcG0004953 dd_Smed_v4_3455_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30014006h1SMcG0004953 dd_Smed_v4_3455_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30014006h1SMcG0004953 dd_Smed_v4_3455_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 3 cellSMED30014006h1SMcG0004953 dd_Smed_v4_3455_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A0H3YF06 (Slc16a-5 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=slc16a-5 PE=2 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 1.269e-12
Identity = 43/75 (57.33%), Postives = 53/75 (70.67%), Query Frame = 1
Query:   46 KGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYR-T*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            KG  C+ GGFLI FSLG+IYTFGN+SPYIASY++ R   Q V N     + +F+LA  SQ  TMS GG+L+KK G
Sbjct:   11 KGYLCILGGFLIHFSLGSIYTFGNISPYIASYMRSRPVTQSVKNSDMVWIFAFALA--SQGLTMSFGGVLDKKVG 83          
BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A1I8HYG0 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 6.202e-11
Identity = 36/75 (48.00%), Postives = 51/75 (68.00%), Query Frame = 1
Query:   46 KGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT-*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            KGI  V GGFLI F+LGT+YTFGNMSPY+ SY++  +  +++G         F L++F Q  +M+ GGL+EK+ G
Sbjct:    6 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYP--DATWIFGLSIFGQGASMAFGGLIEKRIG 78          
BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A267H5U2 (MFS domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000477g2 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 6.460e-11
Identity = 36/75 (48.00%), Postives = 51/75 (68.00%), Query Frame = 1
Query:   46 KGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT-*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            KGI  V GGFLI F+LGT+YTFGNMSPY+ SY++  +  +++G         F L++F Q  +M+ GGL+EK+ G
Sbjct:    8 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYP--DATWIFGLSIFGQGASMAFGGLIEKRIG 80          
BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A1I8HL50 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 71.633 bits (174), Expect = 6.692e-11
Identity = 36/75 (48.00%), Postives = 51/75 (68.00%), Query Frame = 1
Query:   46 KGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT-*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            KGI  V GGFLI F+LGT+YTFGNMSPY+ SY++  +  +++G         F L++F Q  +M+ GGL+EK+ G
Sbjct:    6 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYP--DATWIFGLSIFGQGASMAFGGLIEKRIG 78          
BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A1I8H205 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 7.450e-11
Identity = 36/75 (48.00%), Postives = 51/75 (68.00%), Query Frame = 1
Query:   46 KGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT-*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            KGI  V GGFLI F+LGT+YTFGNMSPY+ SY++  +  +++G         F L++F Q  +M+ GGL+EK+ G
Sbjct:    6 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYP--DATWIFGLSIFGQGASMAFGGLIEKRIG 78          
BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060694.1 (SMESG000060694.1)

HSP 1 Score: 88.5817 bits (218), Expect = 3.394e-20
Identity = 48/84 (57.14%), Postives = 55/84 (65.48%), Query Frame = 1
Query:   19 YMSETRNXXKGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT*Q-YVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            Y  +     KGI CV G FL+ FSLGT+YTFGN+SPYIASYLKYRT   ++ N   H +  FSL VF    TMS GG LEKK G
Sbjct:    4 YTKKVDRKIKGIFCVIGAFLLHFSLGTVYTFGNLSPYIASYLKYRTDNTWINNG--HLVWVFSLNVFFLGLTMSFGGFLEKKIG 85          
BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060698.1 (SMESG000060698.1)

HSP 1 Score: 85.1149 bits (209), Expect = 4.553e-19
Identity = 45/81 (55.56%), Postives = 57/81 (70.37%), Query Frame = 1
Query:   28 ETRNXXKGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT*Q-YVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            +  N  KGISCV G FL+ FSLGT++TFGN+SPYIASYLK RT   ++ N   H +  FS+ VF    TM+LGG+LE+K G
Sbjct:    2 KVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNG--HMVWVFSITVFFMGTTMTLGGILERKMG 80          
BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060698.1 (SMESG000060698.1)

HSP 1 Score: 85.1149 bits (209), Expect = 5.037e-19
Identity = 45/81 (55.56%), Postives = 57/81 (70.37%), Query Frame = 1
Query:   28 ETRNXXKGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT*Q-YVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXG 267
            +  N  KGISCV G FL+ FSLGT++TFGN+SPYIASYLK RT   ++ N   H +  FS+ VF    TM+LGG+LE+K G
Sbjct:    2 KVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNG--HMVWVFSITVFFMGTTMTLGGILERKMG 80          
BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060699.1 (SMESG000060699.1)

HSP 1 Score: 82.0333 bits (201), Expect = 5.825e-18
Identity = 47/90 (52.22%), Postives = 55/90 (61.11%), Query Frame = 1
Query:   22 MSETRNXXKGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXGPPXXTCWI 291
            M    N  +GISCV GGF + FSLGT YTFGN+SPY+ASYLKYRT     N   H +  F+ +       MSLGG+LEKK G    TC I
Sbjct:    1 MVRLGNTARGISCVTGGFFLHFSLGTFYTFGNISPYMASYLKYRTSNTWVNSG-HMVWVFAFSALFLGLIMSLGGMLEKKVG-ARITCLI 88          
BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060699.1 (SMESG000060699.1)

HSP 1 Score: 82.0333 bits (201), Expect = 5.830e-18
Identity = 47/90 (52.22%), Postives = 55/90 (61.11%), Query Frame = 1
Query:   22 MSETRNXXKGISCVCGGFLIQFSLGTIYTFGNMSPYIASYLKYRT*QYVGNQR*HGMGSFSLAVFSQAFTMSLGGLLEKKXGPPXXTCWI 291
            M    N  +GISCV GGF + FSLGT YTFGN+SPY+ASYLKYRT     N   H +  F+ +       MSLGG+LEKK G    TC I
Sbjct:    1 MVRLGNTARGISCVTGGFFLHFSLGTFYTFGNISPYMASYLKYRTSNTWVNSG-HMVWVFAFSALFLGLIMSLGGMLEKKVG-ARITCLI 88          
The following BLAST results are available for this feature:
BLAST of MFS domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0H3YF061.269e-1257.33Slc16a-5 (Fragment) OS=Schmidtea mediterranea OX=7... [more]
A0A1I8HYG06.202e-1148.00MFS domain-containing protein OS=Macrostomum ligna... [more]
A0A267H5U26.460e-1148.00MFS domain-containing protein (Fragment) OS=Macros... [more]
A0A1I8HL506.692e-1148.00MFS domain-containing protein OS=Macrostomum ligna... [more]
A0A1I8H2057.450e-1148.00MFS domain-containing protein OS=Macrostomum ligna... [more]
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BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of MFS domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000060694.13.394e-2057.14SMESG000060694.1[more]
SMESG000060698.14.553e-1955.56SMESG000060698.1[more]
SMESG000060698.15.037e-1955.56SMESG000060698.1[more]
SMESG000060699.15.825e-1852.22SMESG000060699.1[more]
SMESG000060699.15.830e-1852.22SMESG000060699.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30014006 ID=SMED30014006|Name=MFS domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=660bp
GGAATNTATNTTTTATCTTATATGAGTGAAACAAGGAACTNATNGAAAGG
GATCTCATGCGTTTGCGGGGGATTCCTGATCCAGTTCTCCCTAGGGACCA
TTTATACGTTTGGCAACATGAGCCCCTATATTGCCTCATATTTGAAATAT
CGCACCTAACAATACGTGGGTAACCAACGGTGACATGGTATGGGATCTTT
CTCATTGGCTGTGTTTTCACAGGCTTTCACCATGTCTCTGGGAGGACTTC
TAGAAAAGAAAATNGGACCCCCGANTTGNACATGCTGGATTTGGTAGTTG
GATANTGAAGCTTAAGGCACAAGNGCTTGANCTTATTTTCGCTATCNAAG
TNCCAANTTTGGGGGCCCGNCATNAGTCACCTTATGGANTTCATTTTTGG
AAACCGGACCCGGACTGNCCATTATTCCCGNTGCTTNTACAACTCCAATG
AAAGNGTTTCCTCNTTCATTCCANGGCCTGNANCAAGANCAAGNTTGTTG
CCGGATATTGACCTANGGGTCCCCTGATNTTCNATNTNNATNCAAACTTA
AGTTCAATTAAATNCNAATGNAATGGCCTCTTCCAAATTCAACTTTTAAC
CTGGTTGGAAAAATATTTTAANCTGANCCCNGGAAGTNCTNNNNNAAATA
TTCCCTTTGG
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0022857transmembrane transporter activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000035Category 3 cell
PLANA:0002032epidermal cell
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0055085transmembrane transport