tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Overview


Name	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Smed ID	SMED30013995
Length (bp)	982

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (SMED30013995) t-SNE clustered cells

Violin plots show distribution of expression levels for tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (SMED30013995) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (SMED30013995) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013995

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
central nervous system	SMED30013995	SMESG000003449.1	DN309123	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005
ovary	SMED30013995	SMESG000003449.1	DN309123	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005
oviduct	SMED30013995	SMESG000003449.1	DN309123	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005
testis	SMED30013995	SMESG000003449.1	DN309123	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005

Note: Hover over icons to view figure legend

Homology

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
Match: TRMT61A (tRNA methyltransferase 61A [Source:HGNC Symbol;Acc:HGNC:23790])

HSP 1 Score: 239.195 bits (609), Expect = 4.592e-77
Identity = 132/305 (43.28%), Postives = 180/305 (59.02%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV   +G +V+ L   PELW+L+LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ R++ P GH++T EFH+QRA+ A +EF +H++   VT   +DV   GF  +   DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GFSE+ T E + + YNV   SL  P++G            TD  A           ++ +      P     GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGT----------GTDGPAG----------SDTSPFRSGTPMKEAVGHTGYLTFAT 285

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
Match: TRMT61A (tRNA methyltransferase 61A [Source:HGNC Symbol;Acc:HGNC:23790])

HSP 1 Score: 150.984 bits (380), Expect = 5.087e-44
Identity = 86/203 (42.36%), Postives = 115/203 (56.65%), Query Frame = 3

Query:  333 PGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            PGS  + AGTGSG+++HA+ R++ P GH++T EFH+QRA+ A +EF +H++   VT   +DV   GF  +   DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GFSE+ T E + + YNV   SL  P++G            TD  A           ++ +      P     GHTGYL+FAT
Sbjct:    6 PGSR-SVAGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGT----------GTDGPAG----------SDTSPFRSGTPMKEAVGHTGYLTFAT 187

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
Match: TRMT61B (tRNA methyltransferase 61B [Source:HGNC Symbol;Acc:HGNC:26070])

HSP 1 Score: 68.1662 bits (165), Expect = 4.557e-12
Identity = 55/195 (28.21%), Postives = 94/195 (48.21%), Query Frame = 3

Query:  144 TKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPEL--WSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEF--------IDH--KMTDIVTGHHRDVLGQGFP-DNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRS 689
            + +GAV    ++ K  G  +++S G  + L   P L  + + +   T I +  D ++IL  +D+ PG TV EAG+GSG ++  L+++V   G V +FE  +    +A K +        + H  +  D V   H+D+ G      +L  DAV LD+  P   +      LK+GG    +   I QV   ++ +R+
Sbjct:  182 SNWGAVPFGKIVGKFPGQILRSSFGKQYML-RRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRT 375

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
Match: TRMT61B (tRNA methyltransferase 61B [Source:HGNC Symbol;Acc:HGNC:26070])

HSP 1 Score: 63.929 bits (154), Expect = 7.915e-11
Identity = 53/178 (29.78%), Postives = 87/178 (48.88%), Query Frame = 3

Query:  141 QTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPEL--WSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEF--------IDH--KMTDIVTGHHRDVLGQGFP-DNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVC 635
             + +GAV    ++ K  G  +++S G  + L   P L  + + +   T I +  D ++IL  +D+ PG TV EAG+GSG ++  L+++V   G V +FE  +    +A K +        + H  +  D V   H+D+ G      +L  DAV LD+  P   +      LK+GG VC
Sbjct:  181 NSNWGAVPFGKIVGKFPGQILRSSFGKQYML-RRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGG-VC 356

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Celegans
Match: W02A11.1 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Source:UniProtKB/TrEMBL;Acc:G5EGR8])

HSP 1 Score: 182.956 bits (463), Expect = 2.099e-55
Identity = 107/307 (34.85%), Postives = 157/307 (51.14%), Query Frame = 3

Query:   51 KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVL--KYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAER-WEAVPQNNTA--------GHTGYLSFAT 938
            ++ I  GD VI+   + ++VP IV        K+GA+RH  +I K +G ++ A+ G+V+ L    +LW+ +LP RTQI+YT D + IL  LD +PGS + E+GTGSG+L+HA+A +V P GH+YT +  E R     +EF  H +  + T   R+V   GF      D V LD+P PW  +    K +    GGR+  FSPC+EQVQR    + +AGF  I T E +     +V          +E  D             + + R + V     E+   A+P+   A         HTGYL+ AT
Sbjct:   12 EDRIQEGDTVIVYVTYGQMVPTIVKRGQTLMMKYGALRHEFIIGKRWGQRLSATAGYVYILRPTSDLWTRALPRRTQILYTADCAQILSLLDAKPGSVICESGTGSGSLSHAIALTVAPTGHLYTHDIDETRTHKVLEEFKVHGLGSVTTAVVRNVCTSGFHVENAADGVFLDVPAPWEAIPFAAKSIFRARGGRLVSFSPCLEQVQRACLAMAAAGFVSIETIELVPEQKKIVSQHRQTLEEFEELGDA------------YPKERKRNVDGTIVEQSSSAIPRITIAIVYPYSQPTHTGYLTHAT 306

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Query:   51 KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVL--KYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAER-WEAVPQNNTA--------GHTGYLSFAT 938
            ++ I  GD VI+   + ++VP IV        K+GA+RH  +I K +G ++ A+ G+V+ L    +LW+ +LP RTQI+YT D + IL  LD +PGS + E+GTGSG+L+HA+A +V P GH+YT +  E R     +EF  H +  + T   R+V   GF      D V LD+P PW  +    K +    GGR+  FSPC+EQVQR    + +AGF  I T E +     +V          +E  D             + + R + V     E+   A+P+   A         HTGYL+ AT
Sbjct:   12 EDRIQEGDTVIVYVTYGQMVPTIVKRGQTLMMKYGALRHEFIIGKRWGQRLSATAGYVYILRPTSDLWTRALPRRTQILYTADCAQILSLLDAKPGSVICESGTGSGSLSHAIALTVAPTGHLYTHDIDETRTHKVLEEFKVHGLGSVTTAVVRNVCTSGFHVENAADGVFLDVPAPWEAIPFAAKSIFRARGGRLVSFSPCLEQVQRACLAMAAAGFVSIETIELVPEQKKIVSQHRQTLEEFEELGDA------------YPKERKRNVDGTIVEQSSSAIPRITIAIVYPYSQPTHTGYLTHAT 306

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Fly
Match: CG14544 (gene:FBgn0039407 transcript:FBtr0346731)

HSP 1 Score: 229.565 bits (584), Expect = 2.393e-73
Identity = 139/316 (43.99%), Postives = 187/316 (59.18%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHD-----ELVPIIVTEN-----NIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNL--KVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNT-AGHTGYLSFAT 938
            M+F   K  I  GD VIL          E VP IV +      +I QT +G+++  ++I   YGSKV+ SKG+ H L   PELW+ +LPHRTQIIYTPD S+I+ QL+++PG+ V E+GTGSG+L+H   R++ P GH++TF+FHE RA  A  EF  H + D VT +HRDV   GF   L  K DAV LDLP P   V H  K LK  GGR C FSPCIEQ QR ++ L   GF+EI++ E +Q+  NVV++   +P I  EF    L+   TD E     +  +     + +++       T  GHTG+L+FAT
Sbjct:    1 MSFLKPKTHIEKGDVVILYLSVSSMHAIEAVPEIVNKKGETIPHIFQTNYGSLKVENIIGVEYGSKVELSKGWAHVLQPTPELWTQTLPHRTQIIYTPDISMIIHQLEVRPGAVVVESGTGSGSLSHYFLRALKPTGHLHTFDFHEARADQARDEFRRHGIADFVTVYHRDVCNLGFGAELDGKADAVFLDLPAPDLAVPHAFKALKLSGGRFCSFSPCIEQSQRCIQELTKLGFNEIVSLEVLQQE-NVVKTR-TLPVIDLEF----LKLPKTD-ETTAATNALESKAPKEVKKYLTSSNPQTLPGHTGFLTFAT 309

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Fly
Match: CG14544 (gene:FBgn0039407 transcript:FBtr0084969)

HSP 1 Score: 229.565 bits (584), Expect = 2.393e-73
Identity = 139/316 (43.99%), Postives = 187/316 (59.18%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHD-----ELVPIIVTEN-----NIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNL--KVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNT-AGHTGYLSFAT 938
            M+F   K  I  GD VIL          E VP IV +      +I QT +G+++  ++I   YGSKV+ SKG+ H L   PELW+ +LPHRTQIIYTPD S+I+ QL+++PG+ V E+GTGSG+L+H   R++ P GH++TF+FHE RA  A  EF  H + D VT +HRDV   GF   L  K DAV LDLP P   V H  K LK  GGR C FSPCIEQ QR ++ L   GF+EI++ E +Q+  NVV++   +P I  EF    L+   TD E     +  +     + +++       T  GHTG+L+FAT
Sbjct:    1 MSFLKPKTHIEKGDVVILYLSVSSMHAIEAVPEIVNKKGETIPHIFQTNYGSLKVENIIGVEYGSKVELSKGWAHVLQPTPELWTQTLPHRTQIIYTPDISMIIHQLEVRPGAVVVESGTGSGSLSHYFLRALKPTGHLHTFDFHEARADQARDEFRRHGIADFVTVYHRDVCNLGFGAELDGKADAVFLDLPAPDLAVPHAFKALKLSGGRFCSFSPCIEQSQRCIQELTKLGFNEIVSLEVLQQE-NVVKTR-TLPVIDLEF----LKLPKTD-ETTAATNALESKAPKEVKKYLTSSNPQTLPGHTGFLTFAT 309

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
Match: trmt61a (tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GENE-040718-5])

HSP 1 Score: 257.299 bits (656), Expect = 3.400e-84
Identity = 138/307 (44.95%), Postives = 192/307 (62.54%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQE--FADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F     LI  GD VI+  GHD ++PI V      QT++G +RH+ DLI + +GSKV  SKG +V+ L   PELW+++LPHRTQI+YT D + I   L+L+PGS V E+GTGSG+L+H++ R++ P GH++T EFH QRA+ A +EF +HK++ +VT  ++DV   GF      DAV LD+P PW  ++H  K LKY GGR+C FSPCIEQVQRT E L   GF EI T E + R ++V   +L +P+ G E  +AD       T ++   +   T  +         A P    AGHTGYL+F++
Sbjct:    1 MSFVEYSELIQEGDVVIIFMGHDSMMPIKVQSGAQTQTRYGVIRHSSDLIGQRFGSKVTCSKGGWVYVLHPTPELWTINLPHRTQILYTTDIANITLMLELKPGSVVCESGTGSGSLSHSILRTIAPTGHLHTVEFHSQRAEKAMQEFKEHKVSHLVTVRNQDVCKDGFGITGVADAVFLDIPSPWEAISHAKKALKYKGGRLCSFSPCIEQVQRTCEALLDHGFEEICTLEVLLRVHDVRTVTLPLPDFGPEEYYADST----QTTSDISQEDVNTSVICRT------ATPPREMAGHTGYLTFSS 297

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
Match: trmt61a (tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GENE-040718-5])

HSP 1 Score: 257.299 bits (656), Expect = 5.725e-84
Identity = 138/307 (44.95%), Postives = 192/307 (62.54%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQE--FADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F     LI  GD VI+  GHD ++PI V      QT++G +RH+ DLI + +GSKV  SKG +V+ L   PELW+++LPHRTQI+YT D + I   L+L+PGS V E+GTGSG+L+H++ R++ P GH++T EFH QRA+ A +EF +HK++ +VT  ++DV   GF      DAV LD+P PW  ++H  K LKY GGR+C FSPCIEQVQRT E L   GF EI T E + R ++V   +L +P+ G E  +AD       T ++   +   T  +         A P    AGHTGYL+F++
Sbjct:    1 MSFVEYSELIQEGDVVIIFMGHDSMMPIKVQSGAQTQTRYGVIRHSSDLIGQRFGSKVTCSKGGWVYVLHPTPELWTINLPHRTQILYTTDIANITLMLELKPGSVVCESGTGSGSLSHSILRTIAPTGHLHTVEFHSQRAEKAMQEFKEHKVSHLVTVRNQDVCKDGFGITGVADAVFLDIPSPWEAISHAKKALKYKGGRLCSFSPCIEQVQRTCEALLDHGFEEICTLEVLLRVHDVRTVTLPLPDFGPEEYYADST----QTTSDISQEDVNTSVICRT------ATPPREMAGHTGYLTFSS 297

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
Match: trmt61a (tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GENE-040718-5])

HSP 1 Score: 166.777 bits (421), Expect = 1.738e-50
Identity = 85/179 (47.49%), Postives = 121/179 (67.60%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVM 563
            M+F     LI  GD VI+  GHD ++PI V      QT++G +RH+ DLI + +GSKV  SKG +V+ L   PELW+++LPHRTQI+YT D + I   L+L+PGS V E+GTGSG+L+H++ R++ P GH++T EFH QRA+ A +EF +HK++ +VT  ++DV   GF      DAV 
Sbjct:    1 MSFVEYSELIQEGDVVIIFMGHDSMMPIKVQSGAQTQTRYGVIRHSSDLIGQRFGSKVTCSKGGWVYVLHPTPELWTINLPHRTQILYTTDIANITLMLELKPGSVVCESGTGSGSLSHSILRTIAPTGHLHTVEFHSQRAEKAMQEFKEHKVSHLVTVRNQDVCKDGFGITGVADAVF 179

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
Match: trmt61b (tRNA methyltransferase 61B [Source:ZFIN;Acc:ZDB-GENE-131127-35])

HSP 1 Score: 69.707 bits (169), Expect = 9.467e-13
Identity = 69/279 (24.73%), Postives = 127/279 (45.52%), Query Frame = 3

Query:  144 TKFGAVRHNDLISKSYGSKVQASKGFVHAL-PLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEF---HEQRAQIAAKEFID-------HKMTDIVTGHHRDVLGQG-FPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVI-ANDA-----ERWEAVPQNNTAGHTGYL 926
            + +G+V H+D+  +  GS ++ SKG    +  ++ E + L +     I Y  D+S +L  +D+  G  V E G+GSG ++  L+R+V   G V + E    H +R+ +  + +++        +  D V  HH D++  G       +++V LD+  P   +  V+  L  G     +   I QV   +E LR +     L  ECI    +  R  L VP++ ++    + +    + +      +T+ V+ + DA      ++ A P     GHT +L
Sbjct:  168 SNWGSVAHDDMEGRPAGSVIRTSKGIPFVIRRVSLEEFVLFMKRGPAIAYPKDASAMLTMMDVTEGDCVLECGSGSGGMSLFLSRAVGYKGSVLSVEIREDHHKRSVLNYQRWLNTWRRRGGQEWPDNVHFHHGDIISAGTLLAGRGLNSVALDMINPHLALPVVVPYLHPGSVCAVYQANITQVIDLLEALRCSALP--LVCECITEVQH--RDWLVVPSLKKDGTFNKRKAPYENGDQDEPSLKTEEVLNSQDAVPFGDVQYIARPHPEQVGHTAFL 442

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Xenopus
Match: tfap2c (transcription factor AP-2 gamma [Source:Xenbase;Acc:XB-GENE-488671])

HSP 1 Score: 262.692 bits (670), Expect = 3.952e-86
Identity = 144/308 (46.75%), Postives = 188/308 (61.04%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIA---NDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F   K  I  GD  I+  GHD + PI +   +  QTK+G +RH+ DLI K YGSKV  SKG +V+ L   PELW+L+LPHRTQI+Y+ D SLI   L+L+PGS V E+GTGSG+L+HA+ R+V P GH+YT EFH+QRA+ A +EF  HK+  +VT  ++DV   GF      DAV LD+P PW  + H    +K  GGR+C FSPCIEQVQRT   L   GF+EI T E + R Y+V   +L V ++G+          A +  +     RTK + A     A     VP   T GHTGYL+FAT
Sbjct:    1 MSFVEYKEFIEDGDTAIVFLGHDSMFPITIQNGSQTQTKYGVIRHSTDLIGKKYGSKVICSKGGWVYILYPTPELWTLNLPHRTQILYSTDISLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKAIEEFRQHKVDHLVTVKNQDVCKHGFGVTGIADAVFLDIPSPWEAIGHAKSAMKSEGGRICSFSPCIEQVQRTCLALEEHGFTEINTLEILLRVYDVRTINLQVADLGR---------AAEEKSSLDGTDRTKQISAVQHGSALFKSGVPPRETVGHTGYLTFAT 299

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Xenopus
Match: TRMT61B (tRNA methyltransferase 61B [Source:NCBI gene;Acc:100380135])

HSP 1 Score: 74.7146 bits (182), Expect = 2.054e-14
Identity = 71/252 (28.17%), Postives = 110/252 (43.65%), Query Frame = 3

Query:   69 GDCVILRFG---HDELVPII-VTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPEL--WSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHH---------RDVLGQGFP--DNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNI 773
            GD VI  F    + E   +  +T++    + +G V H +++ K  G +++ S+GF   L   P L  + L +     I Y  D + +L  +D+ PG  V EAG+GSG +T  L+R+V   G VY+FE       IA K     +    V   +            L    P   ++  DA  LD+  P   +  ++  LK GG    +   I QV   +E +RS      L  E IQ T   V+  L  P++
Sbjct:   53 GDLVIAEFKRRHYTEFKKMFSLTDSGKLNSNWGVVGHMEIVGKLPGQRLRTSRGFEFLLK-RPSLEEYILLMKRGPTISYPKDIAAMLMMMDVSPGDVVLEAGSGSGGMTLFLSRAVGLEGRVYSFEVRADHHAIAKKNVSKWRSAWDVRSRNPWPENVHFINQDLSAALPTMGSVAFDAAALDMLNPQVALPAILTCLKQGGVCAVYVANITQVIDLLEGIRSCRLP--LLCEKIQETS--VKDWLVAPSV 299

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Mouse
Match: Trmt61a (tRNA methyltransferase 61A [Source:MGI Symbol;Acc:MGI:2443487])

HSP 1 Score: 243.817 bits (621), Expect = 4.113e-79
Identity = 136/306 (44.44%), Postives = 185/306 (60.46%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEA-VPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ RSV P GH++T EFH+QRA  A +EF +H+++  VT H +DV   GF      DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GF+E+ T E + + YNV   SL +P++G       LE                  + +DA  + +  P   T GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVCCSGFGVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSLPLPDLGAN----NLETN----------------MGSDASPFRSGTPMKETVGHTGYLTFAT 286

[Close]

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEA-VPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ RSV P GH++T EFH+QRA  A +EF +H+++  VT H +DV   GF      DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GF+E+ T E + + YNV   SL +P++G       LE                  + +DA  + +  P   T GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVCCSGFGVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSLPLPDLGAN----NLETN----------------MGSDASPFRSGTPMKETVGHTGYLTFAT 286

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Mouse
Match: Trmt61a (tRNA methyltransferase 61A [Source:MGI Symbol;Acc:MGI:2443487])

HSP 1 Score: 158.303 bits (399), Expect = 2.139e-47
Identity = 81/169 (47.93%), Postives = 115/169 (68.05%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGF 533
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ RSV P GH++T EFH+QRA  A +EF +H+++  VT H +DV   GF
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVCCSGF 169

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Mouse
Match: Trmt61a (tRNA methyltransferase 61A [Source:MGI Symbol;Acc:MGI:2443487])

HSP 1 Score: 77.0258 bits (188), Expect = 2.568e-17
Identity = 41/91 (45.05%), Postives = 58/91 (63.74%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPD 299
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTD 91

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Match: sp|Q6AY46|TRM61_RAT (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Rattus norvegicus OX=10116 GN=Trmt61a PE=2 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 1.952e-79
Identity = 134/305 (43.93%), Postives = 183/305 (60.00%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ RS+ P GH++T EFH+QRA  A +EF  H+++  VT H +DV   GF      DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GF+E+ T E + + YNV   SL +P++G +  +G +   AT   +                     P   T GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSIAPTGHLHTVEFHQQRADKAREEFQQHRVSQWVTVHTQDVCRSGFGVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSLPLPDLGADDLEGNVGSDATPFRS-------------------GTPMKETVGHTGYLTFAT 286

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Match: sp|Q80XC2|TRM61_MOUSE (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Mus musculus OX=10090 GN=Trmt61a PE=1 SV=1)

HSP 1 Score: 243.817 bits (621), Expect = 2.877e-78
Identity = 136/306 (44.44%), Postives = 185/306 (60.46%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEA-VPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV  S+G +V+ L   PELW+++LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ RSV P GH++T EFH+QRA  A +EF +H+++  VT H +DV   GF      DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GF+E+ T E + + YNV   SL +P++G       LE                  + +DA  + +  P   T GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVCCSGFGVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSLPLPDLGAN----NLETN----------------MGSDASPFRSGTPMKETVGHTGYLTFAT 286

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Match: sp|Q96FX7|TRM61_HUMAN (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1)

HSP 1 Score: 239.195 bits (609), Expect = 2.205e-76
Identity = 132/305 (43.28%), Postives = 180/305 (59.02%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV   +G +V+ L   PELW+L+LPHRTQI+Y+ D +LI   L+L+PGS V E+GTGSG+++HA+ R++ P GH++T EFH+QRA+ A +EF +H++   VT   +DV   GF  +   DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GFSE+ T E + + YNV   SL  P++G            TD  A           ++ +      P     GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGT----------GTDGPAG----------SDTSPFRSGTPMKEAVGHTGYLTFAT 285

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Match: sp|A6H791|TRM61_BOVIN (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Bos taurus OX=9913 GN=TRMT61A PE=2 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 2.470e-76
Identity = 131/305 (42.95%), Postives = 179/305 (58.69%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F   + LI  GD  IL  GH  +V + V      QT+ G +RH+ DLI + +GSKV   +G +V+ L   PELW+L+LPHRTQI+Y+ D +L+   L+L+PGS V E+GTGSG+++HA+ R++ P GH++T EFH+QRA+ A +EF +H++   VT  ++DV   GF  +   DAV LD+P PW  V H    LK  GGR C FSPCIEQVQRT + L + GFSE+ T E + + YNV   SL VP++G                             + A      P   T GHTGYL+FAT
Sbjct:    1 MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALLTMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAERAREEFQEHRVGRWVTVLNQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAACGFSELSTLEVLPQVYNVRTVSLPVPDLGARPGP------------------------DAAPFRSGTPMKETVGHTGYLTFAT 281

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Match: sp|P0CS08|TRM61_CRYNJ (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) OX=214684 GN=TRM61 PE=3 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 3.966e-67
Identity = 113/240 (47.08%), Postives = 151/240 (62.92%), Query Frame = 3

Query:   42 FFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASK---GFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYG--GRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVV 746
            F ++  I  GD VIL    D +  I +T       K+G   H+ LI + YGSK+ +     G+VH L   PELW+LSLPHRTQI+Y PD S I  +L ++ G  V EAGTGSG++TH+L+RSV P+G V +FE+H QR + A KEF  H +T+ V   HR+V  +GF D   V+ V LDLP PW  + H +K L+     R+C FSPC+EQV +TV  LRS GFS+I TQE + RT+ +V
Sbjct:    8 FHSRVHIEAGDIVILYMARDNMTAITITPGETFHNKYGRYPHDMLIGQKYGSKIHSPPPHPGYVHVLRPTPELWTLSLPHRTQILYLPDISYITMRLGVRVGGKVIEAGTGSGSMTHSLSRSVGPSGQVMSFEYHRQRFETALKEFESHGLTN-VRLQHRNVCKEGFGDAQGVEGVFLDLPAPWEAIPHAVKALRRDIITRICCFSPCLEQVLKTVTCLRSEGFSDISTQEVLIRTHELV 246

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Match: A0A3R7JP15 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Clonorchis sinensis OX=79923 GN=TRM61 PE=3 SV=1)

HSP 1 Score: 290.041 bits (741), Expect = 1.803e-92
Identity = 164/362 (45.30%), Postives = 211/362 (58.29%), Query Frame = 3

Query:   27 NFSMTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFP-----DNLK-VDAVMLDLPQPWSMVAHVMKVLK--YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLE--------------------------CGA-----------------TDNEACHKQHRTKFVIANDAER------WEAVPQNNTAGHTGYLSFATW 941
            N ++  F K+  S+GDCV++  G  E   I++ ++ + QT++GA+RHND + K YGSK+  S G VH L L+P LWS SLPHRTQIIY PD+SLI+  LDL PG  V E+GTGSG+LTH LA++V+P G V TF+FH  R + A  EF +H + D +   HRDV  +GFP     DN+  V+AVMLDLPQPW +V  +  V +   GGRVC FSPCIEQVQRT   L+ AGFS+I T EC+QRT++V R+ L+VPN+GQ     RL+                          CG                  T +E      R K      A R      WEAVPQ   AGHTGYL+FA+W
Sbjct:    4 NNAVCPFQKHTASLGDCVLVVTGKLETRAILLQKDAVTQTRYGALRHNDCVGKCYGSKIPTSLGHVHILSLDPILWSASLPHRTQIIYPPDASLIVGGLDLVPGCRVLESGTGSGSLTHFLAQAVWPTGSVVTFDFHAGRVECARDEFKNHGLCDCIKVVHRDVCTEGFPPVGHQDNVAGVNAVMLDLPQPWLVVPSLPAVFQPDSGGRVCSFSPCIEQVQRTCAALQKAGFSQIQTSECLQRTFDVSRAFLNVPNMGQVGIRERLDNQTLVSGPPSESNEPWWTKRHLLPPPCGLNRRRSFSAVEQDGPMEDTISEETSASKRPKCTRPPPARRDESRFSWEAVPQAMMAGHTGYLTFASW 365

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Match: G7YVP6 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Clonorchis sinensis OX=79923 GN=CLF_112018 PE=3 SV=1)

HSP 1 Score: 289.656 bits (740), Expect = 2.497e-92
Identity = 164/362 (45.30%), Postives = 211/362 (58.29%), Query Frame = 3

Query:   27 NFSMTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFP-----DNLK-VDAVMLDLPQPWSMVAHVMKVLK--YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLE--------------------------CGA-----------------TDNEACHKQHRTKFVIANDAER------WEAVPQNNTAGHTGYLSFATW 941
            N ++  F K+  S+GDCV++  G  E   I++ ++ + QT++GA+RHND + K YGSK+  S G VH L L+P LWS SLPHRTQIIY PD+SLI+  LDL PG  V E+GTGSG+LTH LA++V+P G V TF+FH  R + A  EF +H + D +   HRDV  +GFP     DN+  V+AVMLDLPQPW +V  +  V +   GGRVC FSPCIEQVQRT   L+ AGFS+I T EC+QRT++V R+ L+VPN+GQ     RL+                          CG                  T +E      R K      A R      WEAVPQ   AGHTGYL+FA+W
Sbjct:    4 NNAVCPFQKHTASLGDCVLVVTGKLETRAILLQKDAVTQTRYGALRHNDCVGKCYGSKIPTSLGHVHILSLDPILWSASLPHRTQIIYPPDASLIVGGLDLVPGCRVLESGTGSGSLTHFLAQAVWPTGSVVTFDFHAGRVECARDEFKNHGLCDCIKVVHRDVCTEGFPPVGHQDNVAGVNAVMLDLPQPWLVVPSLPAVFQPDSGGRVCSFSPCIEQVQRTCAALQKAGFSQIQTSECLQRTFDVSRAFLNVPNMGQVGIRERLDNQTLVSGPPSESNEPWWTKRHLLPPPCGLNRRRSFSAVEQDGPMEDTISEETSASKRPKCTRPPPARRDESRFSWEAVPQAVMAGHTGYLTFASW 365

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Match: A0A075AIE8 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Opisthorchis viverrini OX=6198 GN=T265_02278 PE=3 SV=1)

HSP 1 Score: 289.656 bits (740), Expect = 2.938e-92
Identity = 164/356 (46.07%), Postives = 207/356 (58.15%), Query Frame = 3

Query:   45 FNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFP-----DNLK-VDAVMLDLPQPWSMVAHVMKVLK--YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLE--------------------------CGA-----------------TDNEACHKQHRTKFVIANDAER------WEAVPQNNTAGHTGYLSFATW 941
            F K+  S+GDC+++  G  E   I++  + + QT++GA+RHND I K YGSK+  S G VH L L+P LWS SLPHRTQIIY PD+SLI+  LDL PG  V E+GTGSG+LTH LA++V+P G V TF+FH  R + A  EF +H + D +   HRDV  +GFP     DNL  V+AVMLDLPQPW +V  +  V +   GGRVC FSPCIEQVQRT   L+ AGFS+I T EC+QRT++V R+ L+VPN+GQ     RL+                          CG                  T +E      R K      A R      WEAVPQ   AGHTGYL+FA+W
Sbjct:   10 FQKHTASLGDCILVVTGKLETRAILLQRDAVTQTRYGALRHNDCIGKCYGSKIATSLGHVHILSLDPILWSASLPHRTQIIYPPDASLIVGGLDLVPGCRVLESGTGSGSLTHFLAQAVWPTGSVVTFDFHAGRVECARDEFKNHGLCDCIKVIHRDVCTEGFPPFGHQDNLAGVNAVMLDLPQPWLVVPSLPAVFQPDSGGRVCSFSPCIEQVQRTCAALQKAGFSQIQTSECLQRTFDVSRAFLNVPNMGQVGICERLDNQALVSGPPSESNEPWWTKRHLLPPPCGLNRRRIFGAVEEDEPTEDTVSEETSASKRPKCTRPPPARRDESRFSWEAVPQAMMAGHTGYLTFASW 365

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Match: A0A4S2LPU6 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Opisthorchis felineus OX=147828 GN=CRM22_005721 PE=3 SV=1)

HSP 1 Score: 286.96 bits (733), Expect = 3.885e-91
Identity = 162/356 (45.51%), Postives = 208/356 (58.43%), Query Frame = 3

Query:   45 FNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFP-----DNLK-VDAVMLDLPQPWSMVAHVMKVLK--YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLE--------------------------CGA-----------------TDNEACHKQHRTKFVIANDAER------WEAVPQNNTAGHTGYLSFATW 941
            F K+  S+GDCV++  G  E   I++ ++ + QT++GA+RHND + K YGSK+  S G VH L L+P LWS SLPHRTQIIY PD+SL++  LDL PG  V E+GTGSG+LTH LA++V+P G V TF+FH  R + A  EF +H + D +   HRDV  +GFP     DN+  V+AVMLDLPQPW +V  +  V +   GGRVC FSPCIEQVQRT   L+ AGFS+I T EC+QRT++V R+ L+VPN+GQ     RL+                          CG                  T +E      R K      A R      WEAVPQ   AGHTGYL+FA+W
Sbjct:   10 FRKHTASLGDCVLVVTGKLETRAILLQKDVVTQTRYGALRHNDCVGKCYGSKIPTSLGHVHILCLDPILWSASLPHRTQIIYPPDASLVVGGLDLVPGCRVLESGTGSGSLTHFLAQAVWPTGSVVTFDFHAGRVECARDEFKNHGLCDCIKVIHRDVCTEGFPPFGHQDNVAGVNAVMLDLPQPWLVVPSLPAVFQPDSGGRVCSFSPCIEQVQRTCAALQKAGFSQIQTSECLQRTFDVSRAFLNVPNMGQVGIRERLDNQALVSGPPSESNEPWWTKRHLLPPPCGLNRRHIFGAVEEDGPTEDTISEETSASKRPKCTRPPPARRDESRFSWEAVPQAMMAGHTGYLTFASW 365

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Match: A0A158R8Y4 (tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Taenia asiatica OX=60517 GN=TASK_LOCUS6323 PE=3 SV=1)

HSP 1 Score: 285.034 bits (728), Expect = 8.084e-91
Identity = 151/338 (44.67%), Postives = 206/338 (60.95%), Query Frame = 3

Query:   45 FNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLK------VDAVMLDLPQPWSMVAHVMKVL-KYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRL------------ECGATDNEACHKQHR----------TKFVIANDAER-----------WEAVPQNNTAGHTGYLSFAT 938
            F KN+ + GD VI+ +  +E+  I +      Q K GA++HND+I K YGS++  S G V+ L L+P +W++S+PHRTQIIY  D+S+I+ QLDL PG  V EAGTGSGALTHALA++V+P GHV TF+FH++R + A+ EF +H + D+V+  HRDVL  GFP+           A+M+DLP+PW +V  + K     GGRVC FSPCIEQVQ+T  NLRSAGFS+I   ECI R Y+ V + L+VPN+GQE A                E   TD+EA     R          + ++  ND+ +           W A+P+    GHTGYL+FA+
Sbjct:   16 FRKNIAAEGDTVIVTYCKNEIQLIKLCRGATTQNKCGAIKHNDVIGKPYGSRIATSMGRVNILALDPAIWAISVPHRTQIIYPIDASMIVGQLDLVPGCRVLEAGTGSGALTHALAQAVWPTGHVSTFDFHQERVERASVEFEEHGLKDVVSVEHRDVLSDGFPEAGSQHNPDGCHAIMIDLPEPWVVVPTIAKCFTSSGGRVCVFSPCIEQVQKTCTNLRSAGFSDIEVIECISRNYSPVHTVLNVPNLGQENATDLFNGTYTYKKAQIGETAETDSEARKGPPRRNERHLFPPLSNYLTPNDSPKGNGQGCRQYGYWAALPRQKDTGHTGYLTFAS 353

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Cavefish
Match: trmt61a (tRNA methyltransferase 61A [Source:NCBI gene;Acc:103022222])

HSP 1 Score: 259.61 bits (662), Expect = 4.791e-85
Identity = 141/309 (45.63%), Postives = 193/309 (62.46%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAER----WEAVPQNNTAGHTGYLSFAT 938
            M+F      I  GD VI+  GH+ ++PI V      QT++GA+RH+ DLI + +GSKV  SKG +V+ L   PELW+++LPHRTQI+Y+ D + I   LDL+PGS V E+GTGSG+L+HA+ R++ P+GH++T EFH QRA+ AA+EF DHK+  +VT  ++DV  +GF      DAV LD+P PW  + H  K  K  GGR+C FSPCIEQVQRT E L   GF EI T E +QR ++V   ++ +  +G E  DG  E      +   ++ R    +AN   +      A P    AGHTGYL+FAT
Sbjct:    1 MSFVEYSEFIKEGDVVIIFLGHESMMPIKVEAGAQTQTRYGAIRHSSDLIGRRFGSKVTCSKGGWVYVLHPTPELWTVNLPHRTQILYSTDIANITLMLDLKPGSVVCESGTGSGSLSHAILRTIAPSGHLHTVEFHAQRAEKAAQEFRDHKVAHLVTVRNQDVCKEGFGVVGVADAVFLDIPSPWEAIVHAKKAFKRKGGRLCSFSPCIEQVQRTCETLLEQGFGEICTLEVLQRVHDVRSVTMPLVYLGPE--DGGPESAKMTTDPAAEEARP---VANPGYQSVTCRTATPPREMAGHTGYLTFAT 304

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Cavefish
Match: trmt61b (tRNA methyltransferase 61B [Source:NCBI gene;Acc:103046613])

HSP 1 Score: 51.9878 bits (123), Expect = 4.254e-7
Identity = 55/210 (26.19%), Postives = 89/210 (42.38%), Query Frame = 3

Query:  114 IIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPEL--WSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHE----------QRAQIAAKEFIDHKMTDIVTGHHRDVL-------GQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLR 686
             ++ E    Q+ +G + H  +     GS ++ S G    L   P L  +SL +     I Y  D S +L  +D+  G TV E+G+GSGA++  L+R+V   G V + E  +          QR +   K     +  D V  H+ D++       GQ F       ++ LD+  P   +  V+  L  G     +   I Q+   +E LR
Sbjct:  167 FLLQEGAKLQSNWGFLPHQTIAGLPSGSVLRTSVGLPMLL-RRPSLEEFSLFMKRGPAISYPKDISAMLMMMDVSEGDTVLESGSGSGAMSLFLSRAVGSRGRVLSVEVRKDHHRCSVLNYQRWRSTWKLRRGEEWPDNVHFHNSDLINSAHLLAGQSF------HSIALDMVSPHLALPTVVPHLHSGAVCAVYLANITQIIDLMEGLR 369

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Cavefish
Match: trmt61b (tRNA methyltransferase 61B [Source:NCBI gene;Acc:103046613])

HSP 1 Score: 51.9878 bits (123), Expect = 4.371e-7
Identity = 55/210 (26.19%), Postives = 89/210 (42.38%), Query Frame = 3

Query:  114 IIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPEL--WSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHE----------QRAQIAAKEFIDHKMTDIVTGHHRDVL-------GQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLR 686
             ++ E    Q+ +G + H  +     GS ++ S G    L   P L  +SL +     I Y  D S +L  +D+  G TV E+G+GSGA++  L+R+V   G V + E  +          QR +   K     +  D V  H+ D++       GQ F       ++ LD+  P   +  V+  L  G     +   I Q+   +E LR
Sbjct:  167 FLLQEGAKLQSNWGFLPHQTIAGLPSGSVLRTSVGLPMLL-RRPSLEEFSLFMKRGPAISYPKDISAMLMMMDVSEGDTVLESGSGSGAMSLFLSRAVGSRGRVLSVEVRKDHHRCSVLNYQRWRSTWKLRRGEEWPDNVHFHNSDLINSAHLLAGQSF------HSIALDMVSPHLALPTVVPHLHSGAVCAVYLANITQIIDLMEGLR 369

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Sea Lamprey
Match: TRMT61A (tRNA methyltransferase 61A [Source:HGNC Symbol;Acc:HGNC:23790])

HSP 1 Score: 243.047 bits (619), Expect = 2.531e-79
Identity = 133/298 (44.63%), Postives = 175/298 (58.72%), Query Frame = 3

Query:   69 GDCVILRFGHDELVPIIVTENNIDQTKFGAVRHND-LISKSYGSKVQA--SKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERW----EAVPQNNTAGHTGYLSFAT 938
            GD VIL  GHD L+P+      + QT+FGAVRH+D L+ + +GS+V    S G+ +AL   PELW+ SLPHRTQI+Y+ D +++   LDL+PGS V E+GTGSG+L+HAL R++ P+GH++T EFHEQRA  AA+EF  H +  + T   RDV   GF      DAV LD+P PW  V H    +K  GGR+C FSPCIEQVQRT + L   GF E  T E + R  +V   SL VP++GQ          + D       H     + + +          P     GHTGYL+FAT
Sbjct:   13 GDTVILYLGHDALLPVRAKAGAVTQTRFGAVRHSDALLGRPFGSRVACGRSGGWAYALHPTPELWTRSLPHRTQILYSTDIAMVTLMLDLRPGSVVCESGTGSGSLSHALLRTIAPSGHLHTVEFHEQRAASAAEEFERHGVGRLATVRCRDVCRDGFGVAGVADAVFLDIPSPWDAVPHARDAMKTSGGRLCSFSPCIEQVQRTCQALAGLGFVEPSTVEVLLRPLDVRTVSLPVPDLGQGGVRA-----SGDGGRPRPPHAVPAGVVDSSRGVYSFKAGCPPREMPGHTGYLTFAT 305

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Yeast
Match: GCD14 (Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000003661])

HSP 1 Score: 186.808 bits (473), Expect = 1.008e-56
Identity = 106/259 (40.93%), Postives = 147/259 (56.76%), Query Frame = 3

Query:   51 KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQ-ASKG-----FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDI-VTGHHRDVLGQGF-----------------PDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRV--CFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVR 749
            K+LI  GD  ++    D + P+ +    +  T++G+  H D+I K YGS++   +KG     FVH L   PELW+LSLPHRTQI+YTPDSS I+ +L+  P S V EAGTGSG+ +HA ARSV   GH+++FEFH  R + A +EF +H + D  VT  HRDV   GF                   +L  + V LDLP PW  + H+  V+    +V  C FSPCIEQV +T++ L   G++++   E   R Y   R
Sbjct:   10 KDLIKEGDLTLIWVSRDNIKPVRMHSEEVFNTRYGSFPHKDIIGKPYGSQIAIRTKGSNKFAFVHVLQPTPELWTLSLPHRTQIVYTPDSSYIMQRLNCSPHSRVIEAGTGSGSFSHAFARSV---GHLFSFEFHHIRYEQALEEFKEHGLIDDNVTITHRDVCQGGFLIKKGDTTSYEFGNNETAASLNANVVFLDLPAPWDAIPHLDSVISVDEKVGLCCFSPCIEQVDKTLDVLEKYGWTDVEMVEIQGRQYESRR 265

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Nematostella
Match: EDO48847 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHG9])

HSP 1 Score: 256.144 bits (653), Expect = 8.371e-85
Identity = 123/251 (49.00%), Postives = 170/251 (67.73%), Query Frame = 3

Query:   36 MTFFNKN-LISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKY-GGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQE 782
            M+F   N  I  GD VIL  GH+ +  I+VT   + QTKFGA  H+D++ K +GSKV   KG++  L   PELW+++LPHRTQI+Y+ D S++L QLD++PGS V E+GTGS +++HAL RS+ P GH+YT+EFHE+R++ A KEFIDH +  +VT  HR+V   GF +    DAV LDLP PW  +    K LK  GGR+C FSPCIEQVQ+T   +R  GF +I   EC+ +T++V   S  +P+ G++
Sbjct:    1 MSFLKYNSTICEGDTVILYLGHNNMHSIVVTAGKVHQTKFGAFPHSDMVGKQFGSKV-CKKGYLFLLHPTPELWTINLPHRTQILYSTDISMVLMQLDIKPGSVVMESGTGSASMSHALIRSIAPTGHLYTYEFHEERSKQARKEFIDHNVDHLVTVTHRNVTADGFLEENIADAVFLDLPSPWDAIKFSKKALKREGGRLCSFSPCIEQVQKTCGVMRDNGFRDIQVMECLLKTFDVKTVSYQMPDFGEK 250

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BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Medaka
Match: trmt61a (tRNA methyltransferase 61A [Source:NCBI gene;Acc:101174312])

HSP 1 Score: 243.817 bits (621), Expect = 5.447e-79
Identity = 134/305 (43.93%), Postives = 185/305 (60.66%), Query Frame = 3

Query:   36 MTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLK-YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            M+F     +I   D  I+  GH+ ++P+ V      QT++G +RH+ DLI + YGSKV  SKG +V+ L   PELW++SLPHRTQI+YT D + I   LDL+PGS V E+GTGSG+L+HA+ R++ P GH++T EFH+QRA+ AA+EF +H+++ +VT  ++DV   GF      DA+ LD+P PW  V H    LK +GGR+C FSPCIEQVQ+T E L   GF EI T E + R ++V   SL +P+ G +      E  A +        +T   I          P     GHTGYL+FAT
Sbjct:    1 MSFVEYSEVIQDSDVAIIYLGHNSVMPVKVQHGAQTQTRYGVIRHSSDLIGQRYGSKVTCSKGGWVYVLHPTPELWTVSLPHRTQILYTTDIATITMMLDLKPGSVVCESGTGSGSLSHAILRTIAPTGHLHTVEFHQQRAEKAAEEFREHRVSHLVTVRNQDVCKDGFGVMGVADAIFLDIPSPWEAVGHAKAALKKHGGRLCSFSPCIEQVQKTAEALTDHGFEEINTLEVLLRVHDVRTVSLPLPDFGPD-CSAHPEPDAMEAPPPAPS-QTSINIKT------TTPPRELPGHTGYLTFAT 297

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Medaka
Match: trmt61a (tRNA methyltransferase 61A [Source:NCBI gene;Acc:101174312])

HSP 1 Score: 243.817 bits (621), Expect = 3.191e-78
Identity = 134/309 (43.37%), Postives = 187/309 (60.52%), Query Frame = 3

Query:   24 LNFSMTFFN-KNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHN-DLISKSYGSKVQASKG-FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLK-YGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFAT 938
            +  +M+F     +I   D  I+  GH+ ++P+ V      QT++G +RH+ DLI + YGSKV  SKG +V+ L   PELW++SLPHRTQI+YT D + I   LDL+PGS V E+GTGSG+L+HA+ R++ P GH++T EFH+QRA+ AA+EF +H+++ +VT  ++DV   GF      DA+ LD+P PW  V H    LK +GGR+C FSPCIEQVQ+T E L   GF EI T E + R ++V   SL +P+ G +      E  A +        +T   I          P     GHTGYL+FAT
Sbjct:   56 VALAMSFVEYSEVIQDSDVAIIYLGHNSVMPVKVQHGAQTQTRYGVIRHSSDLIGQRYGSKVTCSKGGWVYVLHPTPELWTVSLPHRTQILYTTDIATITMMLDLKPGSVVCESGTGSGSLSHAILRTIAPTGHLHTVEFHQQRAEKAAEEFREHRVSHLVTVRNQDVCKDGFGVMGVADAIFLDIPSPWEAVGHAKAALKKHGGRLCSFSPCIEQVQKTAEALTDHGFEEINTLEVLLRVHDVRTVSLPLPDFGPD-CSAHPEPDAMEAPP-PAPSQTSINIKT------TTPPRELPGHTGYLTFAT 356

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Medaka
Match: trmt61b (tRNA methyltransferase 61B [Source:NCBI gene;Acc:101170634])

HSP 1 Score: 59.6918 bits (143), Expect = 1.377e-9
Identity = 72/293 (24.57%), Postives = 122/293 (41.64%), Query Frame = 3

Query:  141 QTKFGAVRHNDLISKSYGSKVQASKG---FVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEF---HEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLK-----------------VDAVMLDLPQPWSMVAHVMKVLKYGGRVC-FFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAER-------WEAVPQNNTAGHTGYL 926
            Q+ +G + H D+     G  ++ S+G   F+    L  E + L +     I Y  D++ +L  +D+  G  V E+G+GSGA++  L+R+V   G V + E    H +RA       ++++        HR   G+ +PDN++                  +A+ LD+ +P   +  V+  L Y G VC  +   I QV   +E LR  G   +    C + T   VR  L  P + ++      +   T+ +  H +       AND          + A P      HT +L
Sbjct:  200 QSSWGVILHEDIAGHPAGCFLKTSRGVSIFIRRASL--EDYVLYMKRGPAIAYPKDAANMLMMMDVTEGDCVLESGSGSGAMSLFLSRAVGSKGSVVSLEVRKDHHKRA------VLNYERWRKSWSLHR---GEQWPDNVEFYNADLCTASPLLSGHAFNAIALDMIRPHLALPTVLPHL-YPGAVCAVYLANITQVIDLLEGLRCCGLPVL----CERVTEMPVRDWLVAPALQKDGQFHTRQAPPTEEDETHTEAEDS---ANDGSSPAFGSVPYIARPHPEQMSHTAFL 473

[Close]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Planmine SMEST
Match: SMESG000003449.1 (SMESG000003449.1)

HSP 1 Score: 646.736 bits (1667), Expect = 0.000e+0
Identity = 307/307 (100.00%), Postives = 307/307 (100.00%), Query Frame = 3

Query:   36 MTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFATWACECE 956
            MTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFATWACECE
Sbjct:    1 MTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISKSYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQPGSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKMTDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVCFFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEFADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFATWACECE 307

The following BLAST results are available for this feature:

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Celegans
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Fly
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Xenopus
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Mouse
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Cavefish
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Sea Lamprey
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Yeast
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Nematostella
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Medaka
BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Planmine SMEST

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
TRMT61A	4.592e-77	43.28	tRNA methyltransferase 61A [Source:HGNC Symbol;Acc...	[more]
TRMT61A	5.087e-44	42.36	tRNA methyltransferase 61A [Source:HGNC Symbol;Acc...	[more]
TRMT61B	4.557e-12	28.21	tRNA methyltransferase 61B [Source:HGNC Symbol;Acc...	[more]
TRMT61B	7.915e-11	29.78	tRNA methyltransferase 61B [Source:HGNC Symbol;Acc...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
W02A11.1	2.099e-55	34.85	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
W02A11.1	2.099e-55	34.85	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CG14544	2.393e-73	43.99	gene:FBgn0039407 transcript:FBtr0346731	[more]
CG14544	2.393e-73	43.99	gene:FBgn0039407 transcript:FBtr0084969	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
trmt61a	3.400e-84	44.95	tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GE...	[more]
trmt61a	5.725e-84	44.95	tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GE...	[more]
trmt61a	1.738e-50	47.49	tRNA methyltransferase 61A [Source:ZFIN;Acc:ZDB-GE...	[more]
trmt61b	9.467e-13	24.73	tRNA methyltransferase 61B [Source:ZFIN;Acc:ZDB-GE...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
tfap2c	3.952e-86	46.75	transcription factor AP-2 gamma [Source:Xenbase;Ac...	[more]
TRMT61B	2.054e-14	28.17	tRNA methyltransferase 61B [Source:NCBI gene;Acc:1...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Trmt61a	4.113e-79	44.44	tRNA methyltransferase 61A [Source:MGI Symbol;Acc:...	[more]
Trmt61a	4.113e-79	44.44	tRNA methyltransferase 61A [Source:MGI Symbol;Acc:...	[more]
Trmt61a	2.139e-47	47.93	tRNA methyltransferase 61A [Source:MGI Symbol;Acc:...	[more]
Trmt61a	2.568e-17	45.05	tRNA methyltransferase 61A [Source:MGI Symbol;Acc:...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6AY46\|TRM61_RAT	1.952e-79	43.93	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
sp\|Q80XC2\|TRM61_MOUSE	2.877e-78	44.44	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
sp\|Q96FX7\|TRM61_HUMAN	2.205e-76	43.28	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
sp\|A6H791\|TRM61_BOVIN	2.470e-76	42.95	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
sp\|P0CS08\|TRM61_CRYNJ	3.966e-67	47.08	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3R7JP15	1.803e-92	45.30	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
G7YVP6	2.497e-92	45.30	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
A0A075AIE8	2.938e-92	46.07	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
A0A4S2LPU6	3.885e-91	45.51	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]
A0A158R8Y4	8.084e-91	44.67	tRNA (adenine(58)-N(1))-methyltransferase catalyti...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
trmt61a	4.791e-85	45.63	tRNA methyltransferase 61A [Source:NCBI gene;Acc:1...	[more]
trmt61b	4.254e-7	26.19	tRNA methyltransferase 61B [Source:NCBI gene;Acc:1...	[more]
trmt61b	4.371e-7	26.19	tRNA methyltransferase 61B [Source:NCBI gene;Acc:1...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
TRMT61A	2.531e-79	44.63	tRNA methyltransferase 61A [Source:HGNC Symbol;Acc...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
GCD14	1.008e-56	40.93	Subunit of tRNA (1-methyladenosine) methyltransfer...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO48847	8.371e-85	49.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
trmt61a	5.447e-79	43.93	tRNA methyltransferase 61A [Source:NCBI gene;Acc:1...	[more]
trmt61a	3.191e-78	43.37	tRNA methyltransferase 61A [Source:NCBI gene;Acc:1...	[more]
trmt61b	1.377e-9	24.57	tRNA methyltransferase 61B [Source:NCBI gene;Acc:1...	[more]

BLAST of tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000003449.1	0.000e+0	100.00	SMESG000003449.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013995 ID=SMED30013995|Name=tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A|organism=Schmidtea mediterranea sexual|type=transcript|length=982bp
TTATTTAAATTAATATTAATTAACTTAATTTCAGCATGACATTTTTTAAT
AAAAATTTAATTAGTGTTGGAGATTGTGTTATTTTGAGATTCGGTCATGA
TGAATTAGTTCCTATTATTGTTACCGAAAACAATATTGATCAGACAAAAT
TTGGTGCTGTGAGACATAATGACTTAATCAGTAAAAGTTATGGTTCAAAA
GTTCAAGCTAGTAAGGGATTTGTGCATGCACTGCCATTAAATCCGGAACT
ATGGAGTCTATCTTTGCCACATCGAACTCAAATTATATACACACCGGATT
CGAGCCTTATTTTATGTCAACTTGATCTTCAACCGGGATCAACTGTAGCT
GAAGCAGGAACAGGAAGTGGAGCTTTGACACATGCGCTAGCTCGATCAGT
TTACCCTAACGGGCACGTTTACACATTTGAGTTTCATGAACAACGAGCTC
AAATCGCTGCTAAAGAATTCATAGACCATAAAATGACAGACATTGTCACT
GGTCACCATAGAGATGTTTTAGGGCAAGGATTTCCCGACAACTTAAAAGT
CGATGCCGTGATGCTTGACTTGCCACAGCCATGGAGCATGGTTGCACACG
TTATGAAAGTATTGAAATACGGTGGCCGAGTGTGTTTCTTCTCTCCATGC
ATCGAGCAAGTCCAGCGCACCGTGGAGAATTTACGATCGGCGGGATTTTC
AGAAATCCTAACTCAGGAATGCATTCAACGGACCTATAATGTCGTACGGA
GCAGTCTCGATGTTCCGAATATCGGGCAGGAATTTGCCGACGGCCGACTG
GAATGCGGCGCAACAGATAACGAGGCGTGTCATAAGCAGCATCGGACGAA
ATTTGTCATCGCAAACGATGCCGAACGCTGGGAAGCAGTGCCACAGAATA
ATACGGCCGGTCATACCGGATATTTGAGCTTTGCCACGTGGGCTTGTGAA
TGTGAATAAATTGTGATTTATTTCAAAAAAAA

protein sequence of SMED30013995-orf-1

>SMED30013995-orf-1 ID=SMED30013995-orf-1|Name=SMED30013995-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=308bp
MTFFNKNLISVGDCVILRFGHDELVPIIVTENNIDQTKFGAVRHNDLISK
SYGSKVQASKGFVHALPLNPELWSLSLPHRTQIIYTPDSSLILCQLDLQP
GSTVAEAGTGSGALTHALARSVYPNGHVYTFEFHEQRAQIAAKEFIDHKM
TDIVTGHHRDVLGQGFPDNLKVDAVMLDLPQPWSMVAHVMKVLKYGGRVC
FFSPCIEQVQRTVENLRSAGFSEILTQECIQRTYNVVRSSLDVPNIGQEF
ADGRLECGATDNEACHKQHRTKFVIANDAERWEAVPQNNTAGHTGYLSFA
TWACECE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0031515	tRNA (m1A) methyltransferase complex

Vocabulary: **biological process**
Term	Definition
GO:0008033	tRNA processing
GO:0030488	tRNA methylation
GO:0032259	methylation

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000103	central nervous system
PLANA:0000204	ovary
PLANA:0000205	oviduct
PLANA:0000208	testis

Vocabulary: **INTERPRO**
Term	Definition
IPR029063	SAM-dependent_MTases
IPR014816	tRNA_MeTrfase_Gcd14

Vocabulary: **molecular function**
Term	Definition
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0016740	transferase activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR014816	tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14	PFAM	PF08704	GCD14	coord: 61..301 e-value: 3.0E-82 score: 276.0
IPR014816	tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14	PIRSF	PIRSF017269	GCD14	coord: 2..307 e-value: 7.3E-85 score: 281.9
IPR014816	tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14	PANTHER	PTHR12133	UNCHARACTERIZED METHYLTRANSFERASE	coord: 6..302
IPR014816	tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14	PROSITE	PS51620	SAM_TRM61	coord: 12..303 score: 91.726
None	No IPR available	GENE3D	G3DSA:3.10.330.20		coord: 1..67 e-value: 9.1E-17 score: 62.8
None	No IPR available	GENE3D	G3DSA:3.40.50.150		coord: 70..304 e-value: 6.9E-81 score: 273.0
None	No IPR available	PANTHER	PTHR12133:SF2	TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A	coord: 6..302
None	No IPR available	CDD	cd02440	AdoMet_MTases	coord: 103..201 e-value: 8.54756E-6 score: 42.0319
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases	coord: 8..301