Sh3bp2

Overview
NameSh3bp2
Smed IDSMED30013977
Length (bp)1087
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Sh3bp2 (SMED30013977) t-SNE clustered cells

Violin plots show distribution of expression levels for Sh3bp2 (SMED30013977) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Sh3bp2 (SMED30013977) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Sh3bp2 (SMED30013977) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30013977

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30013977h1SMcG0019871 dd_Smed_v4_10440_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30013977h1SMcG0019871 dd_Smed_v4_10440_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Sh3bp2 vs. TrEMBL
Match: S5WMZ9 (Sh3bp2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 2.282e-33
Identity = 108/316 (34.18%), Postives = 171/316 (54.11%), Query Frame = 2
Query:   62 KLPAQILLQDSSVTFSGYLE-RKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCK------NNMEGSIYSTVSERNEIVDTLLHSDKI---NIYEEPDDLIFQINPVNPTAPPLYP-----TLTQFDNLS-LKSDTSDENV--EYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPF 955
            K PAQ LL+  ++TFSG LE  K + +S   W+KCYV++  GNIYIY +  S  P    +L  F++  ++KNR + P WVF L+P+ ++  +L FAA SE+EM + I +FK G++ S+ +QL   +   ++          NN   +  S +      +   +H ++    N  E  ++ I + +  N    P YP     TL + D+L  + S++  E +     IF GTREEA + L K   +G YL+R    RQ+L+V+ E  IVKY L  +P T+R+ I G    F N+  L+ +Y+ + +PN  C+L  P+
Sbjct:    3 KEPAQSLLRKPNITFSGILETSKTSKMSLHKWVKCYVIVFEGNIYIYENCLSESPKSTNVLSKFNEFHVLKNRKKSPLWVFILQPIDNANSQLSFAAPSEQEMLYVIGKFKEGMMHSQ-SQLSAPNVNFTNPEIYPPYPIINNANLNFQSNLPP----IPKGIHPNERLMENCIETNNEKILKFDNRNSVCAPPYPNINALTLDRRDDLPPIPSESHSEEICMRDFIFNGTREEAAAVLSKVQQIGGYLIRVQGDRQVLSVQTERGIVKYKLYKNPLTERVSIQGFGNEFYNLTDLVKHYYTNNIPNYTCRLKCPY 313          
BLAST of Sh3bp2 vs. Planmine SMEST
Match: SMESG000072396.1 (SMESG000072396.1)

HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0
Identity = 308/309 (99.68%), Postives = 309/309 (100.00%), Query Frame = 2
Query:   38 MAKSNVFHKLPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIYSTVSERNEIVDTLLHSDKINIYEEPDDLIFQINPVNPTAPPLYPTLTQFDNLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPFKFI 964
            MAKSNVFHKLPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVISNGNIYIYSSSTSPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIYSTVSERNEIVDTLLHSDKINIYEEPDDLIFQINPVNPTAPPLYPTLTQFDNLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRI+IAGQKESFENVYHLLSYYHEHYLPNQNCKLLIPFKFI
Sbjct:    1 MAKSNVFHKLPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVISNGNIYIYSSSTSPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIYSTVSERNEIVDTLLHSDKINIYEEPDDLIFQINPVNPTAPPLYPTLTQFDNLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIHIAGQKESFENVYHLLSYYHEHYLPNQNCKLLIPFKFI 309          
BLAST of Sh3bp2 vs. Planmine SMEST
Match: SMESG000006092.1 (SMESG000006092.1)

HSP 1 Score: 142.51 bits (358), Expect = 2.231e-39
Identity = 107/314 (34.08%), Postives = 173/314 (55.10%), Query Frame = 2
Query:   53 VFHKLPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIYSTVSERNEI--VDTLLHSDKI---NIYEEPDDLIFQINPVNPTAPPLYP-----TLTQFDNL-SLKSDTSDENV--EYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPF 955
            V  K PAQ LL+  ++TFSG LE KI+ +SF  W++CYV++  GNIYIY +  S  P    +L  F +  ++KNR + P WVF L+P+ +   +L FAA SE+EM + I +FK G++ S+ + L   +   ++            +T++ ++ +  +   +H ++    N  E  +  +  I+  N    PLYP     TL + ++L  + S++  E +     IF GTREEA + L K   +G YL+R    RQ+L+V+ E  IVKY L  +P T+R+ I G    F N+  L+ +Y+ + +PN  C+L  P+
Sbjct:    3 VMLKEPAQSLLRKPNITFSGILENKISKMSFHIWVRCYVIVFEGNIYIYENCFSESPKSTNVLSKFKEFHVLKNRKKSPLWVFILQPIDNETSQLSFAAPSEQEMLYVIGKFKEGMMHSQ-SHLSAPNVNFTNPGIYPPYPIINSATLNFQSNLPPIPKGIHPNERLMENCIETNNKKVLTIDNRNSVCAPLYPNINALTLERRNDLPPIPSESHSEEICMRDFIFNGTREEAAAVLSKVQQIGGYLIRVQGDRQVLSVQTERGIVKYVLDKNPLTERVSIQGSGNEFYNLTDLVKHYYTNNIPNYTCRLKCPY 315          
BLAST of Sh3bp2 vs. Planmine SMEST
Match: SMESG000006104.1 (SMESG000006104.1)

HSP 1 Score: 132.494 bits (332), Expect = 1.544e-35
Identity = 108/319 (33.86%), Postives = 169/319 (52.98%), Query Frame = 2
Query:   53 VFHKLPAQILLQDSSVTFSGYLE-RKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCK------NNMEGSIYSTVSERNEIVDTLLHSDKI---NIYEEPDDLIFQINPVNPTAPPLYP-----TLTQFDNLS-LKSDTSDENV--EYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPF 955
            V  K PAQ LL+  ++TFSG LE  K + +S   W+K YV++  GNIYIY +  S  P    +L  F +  ++KNR + P WVF L+P+ +   +L FAA SE+EM + I +FK G++ S+ +QL   +   ++          NN   +  S +      +   +H ++    N  E  ++ I  I+  N    P YP     TL + D+L  + S++  E +     IF GTREEA + L K   +G YL+R    RQ+L+V+ E  IVKY L  +P T+R+ + G    F N+  L+ +Y+ + +PN  C+L  P+
Sbjct:    3 VMLKEPAQSLLRKPNITFSGILETSKTSKMSLHKWVKYYVIVFEGNIYIYENCLSESPKSTNVLSKFKEFHVLKNRKKSPLWVFILQPIDNETSQLSFAAPSEQEMLYVIGKFKEGMMHSQ-SQLSAPNVNFTNPGIYPPYPIINNANLNFQSNLPP----IPKGIHPNERLMENCIETNNEKILTIDNRNSVCAPPYPNINALTLERRDDLPPIPSESHSEEICMRDFIFNGTREEAAAVLSKVQQIGGYLIRVQGDRQVLSVQTERGIVKYKLYKNPLTERVSVQGFGNEFYNLTDLVKHYYTNNIPNYTCRLKCPY 316          
BLAST of Sh3bp2 vs. Planmine SMEST
Match: SMESG000072368.1 (SMESG000072368.1)

HSP 1 Score: 101.293 bits (251), Expect = 3.106e-24
Identity = 96/305 (31.48%), Postives = 156/305 (51.15%), Query Frame = 2
Query:  104 FSGYLERKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLI--DSVPELKFAAASEREMNFWISEFKLGIILSKNTQL--KDDSERISSQS---CKNNMEGSIYSTVSERN---EIVDTLLHSDKINIYEEPDDLIFQINPVNPT---------APPLYPTLTQFDNLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPFKF 961
            +SGYL ++I     K WIK ++ +  G+IYIYS   + KP +V IL  +  I+I+  R + P  V ++ P    +SV  L F   +E EM F +  F+  I  SK      K   E I S +    +N+ E   +S + + N   +       SD+ + Y+  ++  F+ N    +           PL    T  ++LS+  D    N++++I  GT  EA+ EL      G+YLVRQD GR+ILTV+C + ++KY L++    + I I      F ++ +LL+YY ++ +P + CKL+IP+K 
Sbjct:    4 YSGYLFQQILNSGKKKWIKVFIKLHKGSIYIYSDDKAIKPKMVAILAGYSTIEILTGRKKHPLHVISICPNSPRNSVVPLVFGTTTEPEMEFIVKLFESNISKSKQNFFFNKSTGENIISNNKTGSRNSFEKESHSELPQHNYNPDYYSNYNSSDESSNYDVAEE-TFKENSEGCSFDEIYFISENTPLQDNETVDNDLSIYVDDCPINLDHIILEGTSIEAYQELKNNICHGAYLVRQDKGRKILTVQCANEVLKYELITHQNNNCIQIKNNNIVFNSLQNLLNYYQKNDIPGRQCKLVIPYKL 307          
BLAST of Sh3bp2 vs. Planmine SMEST
Match: SMESG000072391.1 (SMESG000072391.1)

HSP 1 Score: 92.0485 bits (227), Expect = 7.584e-21
Identity = 86/302 (28.48%), Postives = 146/302 (48.34%), Query Frame = 2
Query:   65 LPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVXXXXXXXXXXXXXXPKPVLVCILGAFHQIQII---KNRIQPPFWVFTLKPLIDSVPELKFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIYSTVSERNEIVDTLLHSDKINIYEEPDDLIFQINPVNPTAPPLYPTLTQFDNLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILTVKCESNIVKYCLLSDPKTDRIYIAGQKESFENVXXXXXXXXXXXXPNQNCKLLIPFKF 961
            + AQ L       F+G L  K++ L  K W+K Y ++  G+ Y+YS+  + +P +V IL A  +++I    KNR    F VF+     +S+ +LKF   S+  ++  +  F   I    N     +       S        + S     N + + L       IY+ P+  +       P       +      LS+ S+T + N++ VIF GT  EA+ EL K    G+YLVR++N  + LTV+    ++KY L+++   + + I  Q+  F ++  LL+YYH++ +P + CKL+IP+K 
Sbjct:    6 VDAQTLRATDEKRFAGDLFHKVSHLGSKTWVKVYTILFKGSFYVYSNVDAKQPKMVVILTASSKVEITSNRKNRYMLSFTVFS-NSNDNSIRQLKFGTYSQEILSTLMKSFNESINRGANNYFTSNEPNDFKMSL-----NRVNSNTHFENNVNEELF------IYDMPERPVIGFKNGMPDFDLSETSSQNSIYLSIDSETYNINLDDVIFKGTSYEAYQELEKNVCYGAYLVREENNAKRLTVQTRDEVLKYVLITNTNNNFVQIQNQEMKFNSLQDLLAYYHKNDIPGRKCKLVIPYKL 295          
The following BLAST results are available for this feature:
BLAST of Sh3bp2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 1
Match NameE-valueIdentityDescription
S5WMZ92.282e-3334.18Sh3bp2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=... [more]
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BLAST of Sh3bp2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sh3bp2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000072396.10.000e+099.68SMESG000072396.1[more]
SMESG000006092.12.231e-3934.08SMESG000006092.1[more]
SMESG000006104.11.544e-3533.86SMESG000006104.1[more]
SMESG000072368.13.106e-2431.48SMESG000072368.1[more]
SMESG000072391.17.584e-2128.48SMESG000072391.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013977 ID=SMED30013977|Name=Sh3bp2|organism=Schmidtea mediterranea sexual|type=transcript|length=1087bp
CTATTTTTAGATTAATTTATTGATAATTTTAATTAATATGGCGAAAAGTA
ATGTGTTTCACAAGTTACCAGCTCAAATTTTACTTCAAGATTCTAGTGTT
ACGTTCTCAGGTTATTTAGAACGAAAAATTACTATGCTTTCATTTAAACA
CTGGATTAAATGTTATGTTGTGATATCAAATGGAAATATTTACATTTATT
CATCAAGCACATCTCCGAAACCTGTTCTAGTATGCATTCTTGGTGCATTT
CATCAAATTCAAATCATTAAAAATCGAATTCAACCACCATTTTGGGTTTT
TACCTTAAAACCACTTATTGATTCAGTTCCTGAGTTAAAATTTGCTGCAG
CTTCAGAACGGGAAATGAATTTTTGGATAAGTGAATTCAAATTAGGAATT
ATATTATCAAAAAATACTCAATTAAAAGATGATTCTGAAAGAATAAGTAG
TCAGTCTTGTAAAAATAACATGGAAGGAAGTATTTATTCAACTGTTTCAG
AAAGGAATGAAATTGTAGATACACTTTTGCATTCGGATAAAATAAATATT
TACGAAGAGCCAGATGATTTAATATTTCAAATTAATCCAGTTAACCCCAC
TGCTCCTCCGTTATATCCAACTTTAACACAATTTGATAATTTATCATTAA
AATCAGATACAAGTGACGAAAATGTGGAGTATGTAATATTTTATGGTACA
CGCGAGGAAGCTTTTTCAGAATTGTTAAAGCGTCCTTACCTTGGTTCTTA
TTTAGTTAGGCAGGATAATGGACGGCAAATATTAACTGTTAAATGTGAAA
GTAATATTGTTAAATATTGTTTGTTATCAGACCCGAAAACAGATCGGATT
TATATTGCTGGTCAAAAAGAATCTTTCGAAAACGTTTATCATCTATTATC
TTATTACCATGAGCATTATCTTCCCAACCAAAATTGCAAATTATTGATAC
CTTTTAAGTTCATTTAATGAAATTTTGCGGAATTAAACTTAACTATGCGA
TAATTGCTATGGAAAAGGGAAAATTTGAGTTTAATAGTTTATTTTTATAA
GTTATACATATATGAATGTTATAAATTTTATATAAAC
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protein sequence of SMED30013977-orf-1

>SMED30013977-orf-1 ID=SMED30013977-orf-1|Name=SMED30013977-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=310bp
MAKSNVFHKLPAQILLQDSSVTFSGYLERKITMLSFKHWIKCYVVISNGN
IYIYSSSTSPKPVLVCILGAFHQIQIIKNRIQPPFWVFTLKPLIDSVPEL
KFAAASEREMNFWISEFKLGIILSKNTQLKDDSERISSQSCKNNMEGSIY
STVSERNEIVDTLLHSDKINIYEEPDDLIFQINPVNPTAPPLYPTLTQFD
NLSLKSDTSDENVEYVIFYGTREEAFSELLKRPYLGSYLVRQDNGRQILT
VKCESNIVKYCLLSDPKTDRIYIAGQKESFENVYHLLSYYHEHYLPNQNC
KLLIPFKFI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005070SH3/SH2 adaptor activity
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0009967positive regulation of signal transduction
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036860SH2_dom_sf
IPR035848SH3BP2
IPR000980SH2
IPR001849PH_domain
IPR011993PH-like_dom_sf
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000980SH2 domainSMARTSM00252SH2_5coord: 215..296
e-value: 0.0086
score: 23.6
IPR000980SH2 domainPROSITEPS50001SH2coord: 217..306
score: 8.847
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 21..124
e-value: 1.0E-4
score: 31.6
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 20..122
score: 7.331
IPR036860SH2 domain superfamilyGENE3DG3DSA:3.30.505.10coord: 204..308
e-value: 6.1E-9
score: 37.5
IPR036860SH2 domain superfamilySUPERFAMILYSSF55550SH2 domaincoord: 221..305
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 14..138
e-value: 1.3E-9
score: 39.6
IPR035848SH3 domain-binding protein 2PANTHERPTHR15126SH3-BINDINGcoord: 9..193
coord: 204..306
NoneNo IPR availableCDDcd00173SH2coord: 218..290
e-value: 4.51518E-8
score: 47.8355
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 13..135