5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled

Overview


Name	5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled
Smed ID	SMED30013958
Length (bp)	1945

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled (SMED30013958) t-SNE clustered cells

Violin plots show distribution of expression levels for 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled (SMED30013958) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled (SMED30013958) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013958

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
muscle cell	SMED30013958	h1SMcG0003596	dd_Smed_v4_13509_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Human
Match: HTR2A (5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293])

HSP 1 Score: 73.1738 bits (178), Expect = 5.359e-13
Identity = 55/187 (29.41%), Postives = 91/187 (48.66%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261

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Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Human
Match: HTR2A (5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293])

HSP 1 Score: 66.2402 bits (160), Expect = 5.888e-11
Identity = 40/118 (33.90%), Postives = 62/118 (52.54%), Query Frame = 1

Query:  409 MCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   63 LCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 177

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Human
Match: HTR2C (5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295])

HSP 1 Score: 60.4622 bits (145), Expect = 5.922e-9
Identity = 39/145 (26.90%), Postives = 71/145 (48.97%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISEST--IQDGVCFISDPNFLILRSVMCFGFPISVSSI 723
            FL S+ +A++ +  +  P  +++ +      +   +C  W  LD L     I+HL   SLD Y+ +R+P   SR+   TK I   +K++  W +S   S     I    E    + +  C ++DPNF+++ S + F  P+++  I
Sbjct:   91 FLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI---MKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVI 232

[Close]

Query:  307 FLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISEST--IQDGVCFISDPNFLILRSVMCFGFPISVSSI 723
            FL S+ +A++ +  +  P  +++ +      +   +C  W  LD L     I+HL   SLD Y+ +R+P   SR+   TK I   +K++  W +S   S     I    E    + +  C ++DPNF+++ S + F  P+++  I
Sbjct:   91 FLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI---MKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVI 232

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Match: ser-1 (SERotonin/octopamine receptor family; Serotonin receptor [Source:UniProtKB/TrEMBL;Acc:O17470])

HSP 1 Score: 55.4546 bits (132), Expect = 9.919e-8
Identity = 45/177 (25.42%), Postives = 82/177 (46.33%), Query Frame = 1

Query:  199 VNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHI-MCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSI 723
            V L L  V+ +I  I N     A+ +      V   FL S+ +A+L +  I  P  I+ ++        + MC+ + Y D  LC+  I+H+   SLD YL +  P R  + +K ++  +K++  W ++ + S     +A    + I ++  C I    ++I  S M F  P+ +  +
Sbjct:   57 VALFLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLRTRNRSKTLI-FIKIAIVWVVTLLVSCPIAVLAMHDTANILRNNQCMIFSRYYIIYGSTMTFLIPLCIMGV 232

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Match: ser-1 (SERotonin/octopamine receptor family; Serotonin receptor [Source:UniProtKB/TrEMBL;Acc:O17470])

HSP 1 Score: 55.0694 bits (131), Expect = 1.168e-7
Identity = 45/177 (25.42%), Postives = 82/177 (46.33%), Query Frame = 1

Query:  199 VNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHI-MCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSI 723
            V L L  V+ +I  I N     A+ +      V   FL S+ +A+L +  I  P  I+ ++        + MC+ + Y D  LC+  I+H+   SLD YL +  P R  + +K ++  +K++  W ++ + S     +A    + I ++  C I    ++I  S M F  P+ +  +
Sbjct:    9 VALFLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLRTRNRSKTLI-FIKIAIVWVVTLLVSCPIAVLAMHDTANILRNNQCMIFSRYYIIYGSTMTFLIPLCIMGV 184

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Match: ser-7 (SERotonin/octopamine receptor family [Source:UniProtKB/TrEMBL;Acc:Q8T3C1])

HSP 1 Score: 51.9878 bits (123), Expect = 9.142e-7
Identity = 51/194 (26.29%), Postives = 92/194 (47.42%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRY--MDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQ-ISESTIQD--GVCFISDPNFLI--LRSVMCFGFPISVSSIL---VFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNL 858
             L S+ VA+ F+  +  P  +I  +     +   MC  +T  D  LC   I++L   S+D YL +  P RY    +TK+I+  + ++  W ++ + S +   IA  +++ T  D  G C +  P+F+     +++ F  P  +  IL   ++ AAK L++ DR +    S +  E      AET   L+ +  +
Sbjct:   79 LLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIM--MYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVI-PHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETI 269

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Match: ser-7 (SERotonin/octopamine receptor family [Source:UniProtKB/TrEMBL;Acc:Q8T3C1])

HSP 1 Score: 51.9878 bits (123), Expect = 9.464e-7
Identity = 51/194 (26.29%), Postives = 92/194 (47.42%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRY--MDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQ-ISESTIQD--GVCFISDPNFLI--LRSVMCFGFPISVSSIL---VFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNL 858
             L S+ VA+ F+  +  P  +I  +     +   MC  +T  D  LC   I++L   S+D YL +  P RY    +TK+I+  + ++  W ++ + S +   IA  +++ T  D  G C +  P+F+     +++ F  P  +  IL   ++ AAK L++ DR +    S +  E      AET   L+ +  +
Sbjct:   79 LLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIM--MYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVI-PHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETI 269

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Match: ser-7 (SERotonin/octopamine receptor family [Source:UniProtKB/TrEMBL;Acc:Q8T3C1])

HSP 1 Score: 51.2174 bits (121), Expect = 1.391e-6
Identity = 51/194 (26.29%), Postives = 92/194 (47.42%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRY--MDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQ-ISESTIQD--GVCFISDPNFLI--LRSVMCFGFPISVSSIL---VFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNL 858
             L S+ VA+ F+  +  P  +I  +     +   MC  +T  D  LC   I++L   S+D YL +  P RY    +TK+I+  + ++  W ++ + S +   IA  +++ T  D  G C +  P+F+     +++ F  P  +  IL   ++ AAK L++ DR +    S +  E      AET   L+ +  +
Sbjct:   79 LLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIM--MYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVI-PHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAAQDRLMSHCNSVDASERPRNGSAETKDFLNEKETI 269

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0303603)

HSP 1 Score: 72.4034 bits (176), Expect = 8.543e-13
Identity = 46/154 (29.87%), Postives = 76/154 (49.35%), Query Frame = 1

Query:  256 AICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAF-MAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISV 714
            AI   R L +   V   FL S+ + +L +A +  P  I++ +     +    C++W  LD L C   I+HL   S+D YL LR+P R+  +  +    LK+   W LS   S    +  ++   S + +G C I DP + ++ S++CF  P+ V
Sbjct:   97 AIAWERRLQN---VTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGV 247

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0339322)

HSP 1 Score: 72.4034 bits (176), Expect = 8.543e-13
Identity = 46/154 (29.87%), Postives = 76/154 (49.35%), Query Frame = 1

Query:  256 AICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAF-MAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISV 714
            AI   R L +   V   FL S+ + +L +A +  P  I++ +     +    C++W  LD L C   I+HL   S+D YL LR+P R+  +  +    LK+   W LS   S    +  ++   S + +G C I DP + ++ S++CF  P+ V
Sbjct:   97 AIAWERRLQN---VTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGV 247

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0330144)

HSP 1 Score: 72.4034 bits (176), Expect = 8.800e-13
Identity = 46/154 (29.87%), Postives = 76/154 (49.35%), Query Frame = 1

Query:  256 AICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAF-MAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISV 714
            AI   R L +   V   FL S+ + +L +A +  P  I++ +     +    C++W  LD L C   I+HL   S+D YL LR+P R+  +  +    LK+   W LS   S    +  ++   S + +G C I DP + ++ S++CF  P+ V
Sbjct:   97 AIAWERRLQN---VTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGV 247

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Match: 5-HT2A (gene:FBgn0087012 transcript:FBtr0078854)

HSP 1 Score: 55.0694 bits (131), Expect = 2.065e-7
Identity = 34/140 (24.29%), Postives = 67/140 (47.86%), Query Frame = 1

Query:  295 VVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI--QDGVCFISDPNFLILRSVMCFGFPI 708
            V   FL S+ +A+L ++    P   I   L    +    C  +   D L C+  ILH+   SL  Y+ +R+P      + + LT +K++  W ++ + S++   +  ++E  I  +  +C I++  F +  S++ F  P+
Sbjct:  319 VTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPM 458

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Match: 5-HT2A (gene:FBgn0087012 transcript:FBtr0300474)

HSP 1 Score: 54.6842 bits (130), Expect = 2.207e-7
Identity = 34/140 (24.29%), Postives = 67/140 (47.86%), Query Frame = 1

Query:  295 VVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI--QDGVCFISDPNFLILRSVMCFGFPI 708
            V   FL S+ +A+L ++    P   I   L    +    C  +   D L C+  ILH+   SL  Y+ +R+P      + + LT +K++  W ++ + S++   +  ++E  I  +  +C I++  F +  S++ F  P+
Sbjct:  319 VTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPM 458

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Match: htr2aa (5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a [Source:ZFIN;Acc:ZDB-GENE-070912-500])

HSP 1 Score: 71.2478 bits (173), Expect = 9.949e-13
Identity = 49/174 (28.16%), Postives = 86/174 (49.43%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSS 756
            IL + A+   R L + T     FL S+ VA++ L  +  P  +++ +   S      +C  W YLD L     I+HL   SLD Y+ +R+P R+  S  +     K++A WT+S   S     +     + + +DG C ++D +F+++ S + F  P+++  +  FL   +L S
Sbjct:   23 ILVIMAVNLERKLQNATNY---FLMSLAVADMLLGLLVMPVSMVTIVYGYSWPFPASLCPMWIYLDVLFSTASIMHLCAISLDRYVAIRNPIRHNRSNSRSRARAKITAVWTISAGISMPIPVLGLRDHTKVFKDGSCLLTDNSFVLIGSFVAFFVPLTIMVVTYFLTISALQS 193

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Match: htr2ab (5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-120215-60])

HSP 1 Score: 67.0106 bits (162), Expect = 3.576e-11
Identity = 54/190 (28.42%), Postives = 92/190 (48.42%), Query Frame = 1

Query:  199 VNLLLAGVII--VIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS-MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSS 756
            V LL++ VII  V   IL + A+   R L + T     FL S+ + ++ L  +  P  +++ +   T  +   +C  W YLD L     I+HL   SLD Y+ +R+P  +  S       +K+ A WT+S V S     +     S + ++  C ++D NF+++ S + F  P+ +  +  FL   +L S
Sbjct:   64 VALLISLVIIITVTGNILVIMAVSLERKLQNATNY---FLRSLAITDMLLGILVMPVAMVTILYGYTWPLPRTLCPIWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRSNSLTKARVKIIAAWTISVVISMPVPVLGLHDHSKVFRNESCQLTDNNFVLIGSFVAFFVPLIIMVVTYFLTISALQS 250

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Match: htr2cl1 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [Source:ZFIN;Acc:ZDB-GENE-081104-48])

HSP 1 Score: 65.855 bits (159), Expect = 7.398e-11
Identity = 48/175 (27.43%), Postives = 88/175 (50.29%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIA-QISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            IL + A+   + L + T     FL S+ VA++ +  +  P  +I+ +   +  +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +   LK++A WT+S   S     I     E  +++G+C +++  F+++ S + F  P+ +  +   L  ++L
Sbjct:   86 ILVILAVSLEKKLQNATNF---FLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---LKIAAVWTISIGISMPIPVIGLSNREKVLKNGICALNEELFILVGSFVAFFIPLVIMVVTYCLTVQAL 254

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Match: htr2cl1 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [Source:ZFIN;Acc:ZDB-GENE-081104-48])

HSP 1 Score: 65.855 bits (159), Expect = 7.478e-11
Identity = 48/175 (27.43%), Postives = 88/175 (50.29%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIA-QISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            IL + A+   + L + T     FL S+ VA++ +  +  P  +I+ +   +  +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +   LK++A WT+S   S     I     E  +++G+C +++  F+++ S + F  P+ +  +   L  ++L
Sbjct:   87 ILVILAVSLEKKLQNATNF---FLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---LKIAAVWTISIGISMPIPVIGLSNREKVLKNGICALNEELFILVGSFVAFFIPLVIMVVTYCLTVQAL 255

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Match: htr2cl1 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [Source:ZFIN;Acc:ZDB-GENE-081104-48])

HSP 1 Score: 65.855 bits (159), Expect = 7.478e-11
Identity = 48/175 (27.43%), Postives = 88/175 (50.29%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIA-QISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            IL + A+   + L + T     FL S+ VA++ +  +  P  +I+ +   +  +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +   LK++A WT+S   S     I     E  +++G+C +++  F+++ S + F  P+ +  +   L  ++L
Sbjct:   87 ILVILAVSLEKKLQNATNF---FLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---LKIAAVWTISIGISMPIPVIGLSNREKVLKNGICALNEELFILVGSFVAFFIPLVIMVVTYCLTVQAL 255

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797])

HSP 1 Score: 70.4774 bits (171), Expect = 3.194e-12
Identity = 60/195 (30.77%), Postives = 95/195 (48.72%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL--VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGV-CFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
             N+P  L +  +++ IA  IL + A+   + L + T     FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +    K+ A WT+S   S          +S + D   C +SD NF+I+ S + F  P+ +  I  FL  KSL
Sbjct:   67 KNWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNY---FLMSLAIADMLLGFLVMPVSMLN-ILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAL---AKIIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSL 254

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797])

HSP 1 Score: 70.4774 bits (171), Expect = 3.620e-12
Identity = 60/195 (30.77%), Postives = 95/195 (48.72%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL--VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGV-CFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
             N+P  L +  +++ IA  IL + A+   + L + T     FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +    K+ A WT+S   S          +S + D   C +SD NF+I+ S + F  P+ +  I  FL  KSL
Sbjct:   65 KNWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNY---FLMSLAIADMLLGFLVMPVSMLN-ILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAL---AKIIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSL 252

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797])

HSP 1 Score: 70.4774 bits (171), Expect = 3.965e-12
Identity = 60/195 (30.77%), Postives = 95/195 (48.72%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL--VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGV-CFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
             N+P  L +  +++ IA  IL + A+   + L + T     FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +    K+ A WT+S   S          +S + D   C +SD NF+I+ S + F  P+ +  I  FL  KSL
Sbjct:   58 KNWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNY---FLMSLAIADMLLGFLVMPVSMLN-ILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAL---AKIIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSL 245

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797])

HSP 1 Score: 70.4774 bits (171), Expect = 4.153e-12
Identity = 60/194 (30.93%), Postives = 95/194 (48.97%), Query Frame = 1

Query:  190 NFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL--VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGV-CFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            N+P  L +  +++ IA  IL + A+   + L + T     FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +    K+ A WT+S   S          +S + D   C +SD NF+I+ S + F  P+ +  I  FL  KSL
Sbjct:   88 NWPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNY---FLMSLAIADMLLGFLVMPVSMLN-ILNDYEWPLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAL---AKIIAVWTISVGISMPVPVFGLQDDSKVFDQENCSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSL 274

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Match: HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [Source:NCBI gene;Acc:100496012])

HSP 1 Score: 60.4622 bits (145), Expect = 4.691e-9
Identity = 49/189 (25.93%), Postives = 91/189 (48.15%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKE 792
            IL + A+   + L + T     FL S+ VA++ +  +  P  +++ +   +  +   +C  W  LD L     I+HL   SLD Y+ +R+P   SR+   TK +   +K++A WT+S   S     I    +S +  +  C ++D NF++L S + F  P+    I+VF    ++    ++   +  +E
Sbjct:   75 ILVIMAVSLEKKLQNATNF---FLMSLAVADMLVGILVMPVSLVTILYDYAWPLPRKLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---MKIAAVWTISIGISMPVPVIGLQDDSRVFVNSSCVLNDENFVLLGSFVAFFIPL---IIMVFTYCLTIQVLQKQATVFMYEE 254

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Mouse
Match: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A [Source:MGI Symbol;Acc:MGI:109521])

HSP 1 Score: 72.7886 bits (177), Expect = 4.749e-13
Identity = 55/187 (29.41%), Postives = 91/187 (48.66%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Mouse
Match: Htr2c (5-hydroxytryptamine (serotonin) receptor 2C [Source:MGI Symbol;Acc:MGI:96281])

HSP 1 Score: 66.2402 bits (160), Expect = 5.261e-11
Identity = 55/213 (25.82%), Postives = 101/213 (47.42%), Query Frame = 1

Query:  190 NFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISEST--IQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDI 807
            N+P   ++  +I+ I   IL + A+   + L++ T     FL S+ +A++ +  +  P  +++ +      +   +C  W  LD L     I+HL   SLD Y+ +R+P   SR+   TK I   +K++  W +S   S     I    ES   + +  C ++DPNF+++ S + F  P+++  I  FL    L      L    ++E+  +I
Sbjct:   55 NWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATN---YFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI---MKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELRNI 261

[Close]

Query:  190 NFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISEST--IQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDI 807
            N+P   ++  +I+ I   IL + A+   + L++ T     FL S+ +A++ +  +  P  +++ +      +   +C  W  LD L     I+HL   SLD Y+ +R+P   SR+   TK I   +K++  W +S   S     I    ES   + +  C ++DPNF+++ S + F  P+++  I  FL    L      L    ++E+  +I
Sbjct:   55 NWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATN---YFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI---MKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELRNI 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Mouse
Match: Adra1a (adrenergic receptor, alpha 1a [Source:MGI Symbol;Acc:MGI:104773])

HSP 1 Score: 60.4622 bits (145), Expect = 3.761e-9
Identity = 58/224 (25.89%), Postives = 104/224 (46.43%), Query Frame = 1

Query:  154 CSMPRIYVGDNNNFPVNLLLAGVII--VIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTA--FMAIAQISESTIQDGVCFIS-DPNFLILRSVMCFGFPISVSSIL---VFLAAKSLS-SFDRKLQTYKSKEKK 798
            C+ P   V  +    + ++L G+II  V+  IL + ++   R L+S   V + ++ ++ VA+L L +   P   I +IL   +   + C  W  +D L C   I+ L   S+D Y+ + +P RY     Q      L   W LS V S    F    Q  E    + +C I+ +P +++  ++  F  P+++  ++   V++ AK  S      L+T KS  ++
Sbjct:   14 CTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHS---VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPE---DETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQ 231

[Close]

Query:  154 CSMPRIYVGDNNNFPVNLLLAGVII--VIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTA--FMAIAQISESTIQDGVCFIS-DPNFLILRSVMCFGFPISVSSIL---VFLAAKSLS-SFDRKLQTYKSKEKK 798
            C+ P   V  +    + ++L G+II  V+  IL + ++   R L+S   V + ++ ++ VA+L L +   P   I +IL   +   + C  W  +D L C   I+ L   S+D Y+ + +P RY     Q      L   W LS V S    F    Q  E    + +C I+ +P +++  ++  F  P+++  ++   V++ AK  S      L+T KS  ++
Sbjct:   14 CTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHS---VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPE---DETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQ 231

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Match: sp|Q75Z89|5HT2A_BOVIN (5-hydroxytryptamine receptor 2A OS=Bos taurus OX=9913 GN=HTR2A PE=2 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.580e-12
Identity = 55/187 (29.41%), Postives = 90/187 (48.13%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P   ++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Match: sp|O46635|5HT2A_CANLF (5-hydroxytryptamine receptor 2A OS=Canis lupus familiaris OX=9615 GN=HTR2A PE=2 SV=2)

HSP 1 Score: 73.9442 bits (180), Expect = 1.772e-12
Identity = 55/187 (29.41%), Postives = 91/187 (48.66%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Match: sp|P18599|5HT2A_CRIGR (5-hydroxytryptamine receptor 2A OS=Cricetulus griseus OX=10029 GN=HTR2A PE=2 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 2.295e-12
Identity = 55/187 (29.41%), Postives = 90/187 (48.13%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + + G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGVSMPIPVFGLQDDSKVFKQGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Match: sp|Q5R4Q6|5HT2A_PONPY (5-hydroxytryptamine receptor 2A OS=Pongo pygmaeus OX=9600 GN=HTR2A PE=2 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.574e-12
Identity = 55/187 (29.41%), Postives = 91/187 (48.66%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Match: sp|P50128|5HT2A_MACMU (5-hydroxytryptamine receptor 2A OS=Macaca mulatta OX=9544 GN=HTR2A PE=2 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 2.574e-12
Identity = 55/187 (29.41%), Postives = 91/187 (48.66%), Query Frame = 1

Query:  208 LLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTS--MQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL 750
            LL  V+I++    N+  I A+            FL S+ +A++ L  +  P  +++ IL      +   +C  W YLD L     I+HL   SLD Y+ +++P   SR+   TK     LK+ A WT+S   S          +S + ++G C ++D NF+++ S + F  P+++  I  FL  KSL
Sbjct:   79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT-ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF---LKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Match: A0A1I8H2Q9 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 8.645e-27
Identity = 60/151 (39.74%), Postives = 92/151 (60.93%), Query Frame = 1

Query:  265 AMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVST--SMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQ--DGVCFISDPNFLILRSVMCFGFP 705
             +R   S   V Y + +S+C A L    +  PP ++ +I+      +   +C+ W Y+DT LCN++ LH LGC++D++LRLR+P  Y  ST +  TCLK+SAPW++SF+Q+TA  A+++  E       G C   DPNF+ILR+ M +G P
Sbjct:  107 GLRREKSLRAVTYYYTNSVCAAMLLQCLVAVPPDVVFQIVGEKYKPLLDTLCIVWLYMDTFLCNLVFLHCLGCAIDTWLRLRYPMSYSHSTGRGSTCLKISAPWSVSFIQTTAEFAVSKQYEELYDAVGGACLHRDPNFVILRACMSYGLP 257

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Match: A0A4E0RHB5 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_002765 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 3.022e-24
Identity = 98/310 (31.61%), Postives = 152/310 (49.03%), Query Frame = 1

Query:  223 IIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTC-LKLSAPWTLSFVQSTAFMAI------AQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETIL--RTSDDPNTVVSSQTFDCTNTL---NYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAA 1116
            +I+++WIL      A+        + Y ++ SM VA +  A+++FP  +I  +L        +C+ W +L+T +C+ ++LHLLG SLD+YLRL+ P  Y  S  +  T  LKL+APW +S +Q+TA + +      A++ E  +    C   D NFLILR+ + F FP+ VS I++FLAA  L    R        +  ED  +TE   F+LL  RH        Q+  L  R +  PNT  + Q  +  +T     +       H  L   ++       NS+ VS  +   +SPS     QC   Q+A
Sbjct:   43 MIILSWILTGVVSVAILRNRRTKHISYMYIVSMSVATVIHASLNFPSSVIFDLLDLEEFSDRLCIIWIFLETAICHSVLLHLLGSSLDTYLRLQMPQWYSLSGGRPATVRLKLAAPWIVSTLQTTAQVLLGDPLPPARLEEQRL----CTCPDVNFLILRTSVAFAFPLLVSVIILFLAAHKLQCIYRP----SFSKAVEDTNSTERFRFKLL--RHVSGRCRTRQKKCLHGRGAVYPNTSANIQGTNGNSTAIQDQFTRILGSTHSALVYNLES----MQNSAAVSSSEHASLSPSYPTKLQCQQVQSA 338

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Match: A0A1I8GR39 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 103.99 bits (258), Expect = 3.443e-22
Identity = 46/94 (48.94%), Postives = 66/94 (70.21%), Query Frame = 1

Query:  430 LDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISES--TIQDGVCFISDPNFLILRSVMCFGFP 705
            +DT LCN++ LH LGC++D++LRLR+P  Y  ST +  TCLK+SAPW++SF+Q+TA  A+++  E       G C   DPNF+ILR+ M +G P
Sbjct:    1 MDTFLCNLVFLHCLGCAIDTWLRLRYPMSYSHSTGKGSTCLKISAPWSVSFIQTTAEFAVSKQYEELYDAAGGACLHRDPNFVILRACMSYGLP 94

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Match: A0A1I8ICS2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 5.649e-22
Identity = 46/94 (48.94%), Postives = 66/94 (70.21%), Query Frame = 1

Query:  430 LDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQ--DGVCFISDPNFLILRSVMCFGFP 705
            +DT LCN++ LH LGC++D++LRLR+P  Y  ST +  TCLK+SAPW++SF+Q+TA  A+++  E       G C   DPNF+ILR+ M +G P
Sbjct:    1 MDTFLCNLVFLHCLGCAIDTWLRLRYPMSYSHSTGRGSTCLKISAPWSVSFIQTTAEFAVSKQYEELYDAVGGACLHRDPNFVILRACMSYGLP 94

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Match: A0A4E0RCP4 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_002642 PE=4 SV=1)

HSP 1 Score: 109.768 bits (273), Expect = 2.782e-21
Identity = 66/198 (33.33%), Postives = 112/198 (56.57%), Query Frame = 1

Query:  226 IVIAWILNL-SAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRY--MDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQ-ISESTIQDG-VCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL--SSFDRKLQTYKSKEKK 798
            ++I+W L +   I  +RS      + + ++ S+ VAN+  A ++FP  +I  ++    +   +CV W + +TL+C+V  LHLLG  LD YLRLR P RY    +T      ++L+APW +S +Q+T  + +   +    +  G +C   D NFLILR+++ F  P+ VS I++FL A ++  SS D K ++    ++K
Sbjct:   45 VIISWSLAIIMTITILRSYRK--HISHFYVISLSVANMIHALVNFPSNVILDLIEPGGLTDAVCVPWIFFETLICHVTHLHLLGSCLDHYLRLRKPHRYGMRYATSSRTIGIRLAAPWVISLLQTTVQILLGDPLPPVQLATGHLCVCPDANFLILRTLIAFALPVLVSLIILFLTAVNVRHSSLDAKFRSICDSQRK 240

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Match: htr2ab (5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-120215-60])

HSP 1 Score: 74.7146 bits (182), Expect = 8.994e-14
Identity = 56/200 (28.00%), Postives = 94/200 (47.00%), Query Frame = 1

Query:  178 GDNNNFPVN-----LLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSS 756
            GD N    N     +LLA VI V   IL + A+   R L + T     FL S+ + ++ L  +  P  +++ +         ++C  W YLD L     I+HL   SLD Y+ +R+P ++  S  +    +K++A WT+S   S     I     S +  +G C + + NF+++ S + F  P+ +  +  FL   +L S
Sbjct:   73 GDENPMQKNWVALLILLAIVITVTGNILVIMAVSLERKLQNATNY---FLMSLAITDMLLGLLVMPVSMVTILYNYRWPFPFVLCPIWIYLDVLFSTASIMHLCAISLDRYIAIRNPIQHSRSNSRARARVKIAAAWTISVGISMPVPVIGLYDHSKVFHNGSCQLKEDNFVLIGSFVAFFVPLIIMVVTYFLTISALQS 269

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Match: htr2cl2 (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2 [Source:ZFIN;Acc:ZDB-GENE-120215-109])

HSP 1 Score: 70.8626 bits (172), Expect = 7.545e-13
Identity = 46/191 (24.08%), Postives = 92/191 (48.17%), Query Frame = 1

Query:  241 ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSL----SSFDRKLQTYKSKEKKE 801
            IL + A+   + L + T     FL S+ VA++ +  +  P  +++ +  S  +  ++C  W +LD L     I+HL   SLD Y+ +R+P ++  S        K++  WT+S V     +   Q  +    +G C +++P+F+++ S + F  P+ +  +   L  K L    ++F +   +Y +   K+
Sbjct:   18 ILVILAVSLEKKLQNATNF---FLRSLAVADMLVGVLVMPASLLNILNYSWPLPQVLCPMWIFLDVLFSTASIMHLCAISLDRYIGIRNPIQHSRSNSSCRAMAKITVVWTISMVSLPIPVIGLQDEQKVFVNGTCQLNEPHFVLVGSFVAFFVPLLIMVVCYCLTVKVLQQHTAAFSQDRGSYVNVNPKQ 205

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621])

HSP 1 Score: 63.929 bits (154), Expect = 2.360e-10
Identity = 57/210 (27.14%), Postives = 102/210 (48.57%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP----SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKED 804
            N + + L L   +IV   +L   A+   ++L + T  +   + S+ VA+L +AT+  P  +  +++       I C  +  LD ++C   IL+L   S+D Y  +  P    +RY  S+K+ +T + +S  W LSF  S   +     + +T  D VC I++P F++  S+M F  P  + ++LV++    +    RK    K   +K D
Sbjct:   33 NYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYL---IVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRY--SSKRRVTVM-ISVVWVLSFAISCPLL-FGLNNTATRDDSVCEIANPAFVVYSSIMSFYVPF-IITLLVYVQIYVVLRKRRKRVNTKRNCQKAD 234

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621])

HSP 1 Score: 63.5438 bits (153), Expect = 2.838e-10
Identity = 57/210 (27.14%), Postives = 102/210 (48.57%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP----SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKED 804
            N + + L L   +IV   +L   A+   ++L + T  +   + S+ VA+L +AT+  P  +  +++       I C  +  LD ++C   IL+L   S+D Y  +  P    +RY  S+K+ +T + +S  W LSF  S   +     + +T  D VC I++P F++  S+M F  P  + ++LV++    +    RK    K   +K D
Sbjct:   33 NYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYL---IVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRY--SSKRRVTVM-ISVVWVLSFAISCPLL-FGLNNTATRDDSVCEIANPAFVVYSSIMSFYVPF-IITLLVYVQIYVVLRKRRKRVNTKRNCQKAD 234

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621])

HSP 1 Score: 63.5438 bits (153), Expect = 2.959e-10
Identity = 57/210 (27.14%), Postives = 102/210 (48.57%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP----SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKED 804
            N + + L L   +IV   +L   A+   ++L + T  +   + S+ VA+L +AT+  P  +  +++       I C  +  LD ++C   IL+L   S+D Y  +  P    +RY  S+K+ +T + +S  W LSF  S   +     + +T  D VC I++P F++  S+M F  P  + ++LV++    +    RK    K   +K D
Sbjct:   27 NYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYL---IVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRY--SSKRRVTVM-ISVVWVLSFAISCPLL-FGLNNTATRDDSVCEIANPAFVVYSSIMSFYVPF-IITLLVYVQIYVVLRKRRKRVNTKRNCQKAD 228

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004593.1 (pep scaffold:Pmarinus_7.0:GL476854:168999:207459:1 gene:ENSPMAG00000004184.1 transcript:ENSPMAT00000004593.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 59.3066 bits (142), Expect = 1.198e-9
Identity = 46/158 (29.11%), Postives = 76/158 (48.10%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKILVSTSMQH----IMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIA-QISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSS 756
            FL S+ VA+L +     P   IS I +  +M+      MC  W +LD L     I+HL   SLD Y+ ++ P   SR+   +K   T LK++A W +S   ++    +  Q  +    +G C ++  NF+I  SV+ F  P+ +  ++  L  + L  
Sbjct:   42 FLMSLAVADLLVGLTVMP---ISVINILYNMRWPLPCEMCPVWVFLDVLFSTASIMHLCAISLDRYIAIKRPIQHSRFNSRSK---TLLKITAVWAISIGIASPIPVLGLQDQQHVFVNGACILNIQNFIIYGSVVSFFLPLLIMVVIYVLTIRLLRG 193

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Match: chrm5b (cholinergic receptor, muscarinic 5b [Source:ZFIN;Acc:ZDB-GENE-041001-169])

HSP 1 Score: 51.2174 bits (121), Expect = 5.508e-7
Identity = 36/169 (21.30%), Postives = 67/169 (39.64%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQ--ISESTIQDGVC---FISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKK 798
            FL S+  A+L +            +    +M  +MC  W  LD +  N  +++LL  S D Y  +  P +Y     +    + +   W +S V     +   Q  + + T+    C   F+S+P      ++  F  PI++  +L +   +      R+  T +  E K
Sbjct:   68 FLLSLAAADLIVGLFSMNLYTAYILTGRWAMGAVMCDLWLTLDYVASNASVMNLLAISFDRYFSITRPLKYKAKRTKRRASIMIGLAWAVSLVLWAPAILFWQHMVGKRTVPQDQCYIQFLSEPIITFGTAIAAFYLPITIMMVLYWRIYRETRRRSRQFATLQGSESK 236

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009127.1 (pep scaffold:Pmarinus_7.0:GL478629:43196:44446:-1 gene:ENSPMAG00000008256.1 transcript:ENSPMAT00000009127.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.0618 bits (118), Expect = 9.258e-7
Identity = 46/187 (24.60%), Postives = 82/187 (43.85%), Query Frame = 1

Query:  250 LSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFIS-DPNFLILRSVMCFGFPISVSSIL---VFLAAKSLSSFDRKLQTYKSKEKK 798
            ++AI   R+L +   V    + S+ V +L ++ +  P   + ++L   ++  ++C  +  LD L C   ILHL   +LD Y  + +P  Y++        + +S  W + F  S   M   +  E       C IS D  + I  +   F  P+ +  +L   +F AA+    F  +    K+ EKK
Sbjct:   58 IAAIALERTLQN---VANYLIGSLAVTDLLVSILVLPMAALYQVLDRWTLGQVVCDIFIALDVLCCTSSILHLCVIALDRYWAITNPIDYVNKRTPRRAVIMISLTWLVGFSISIPPMLGWRTPEDRADPNACKISQDHGYTIYSTFGAFYIPLILMLVLYSRIFRAAR----FRIRKNVKKATEKK 237

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006953.1 (pep scaffold:Pmarinus_7.0:GL477632:7596:14007:1 gene:ENSPMAG00000006283.1 transcript:ENSPMAT00000006953.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.521 bits (114), Expect = 2.906e-6
Identity = 39/139 (28.06%), Postives = 65/139 (46.76%), Query Frame = 1

Query:  307 FLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIA-QISESTIQDGVCFISDPNFLILRSVMCFGFPI 708
            FL S+ VA++ +  +  P  +++ +      +   +C  W YLD L     I+HL   SLD Y+ ++ P   SR+   TK +   LK+ A W +S   S     +  Q       DG C ++  +F+I  S+  F  P+
Sbjct:   62 FLMSLAVADMLVGILVMPISLLNILYGFKWPLPLSLCPVWIYLDVLFSTASIMHLCAISLDRYIAIKKPIEHSRFNSRTKAL---LKILAVWVISVGISMPVPVLGLQDLAYVYTDGSCQMNISDFIIYGSLSSFFLPL 197

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Match: CHRM3 (cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952])

HSP 1 Score: 48.9062 bits (115), Expect = 3.042e-6
Identity = 39/179 (21.79%), Postives = 73/179 (40.78%), Query Frame = 1

Query:  211 LAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQI--SESTIQDGVCFI---SDPNFLILRSVMCFGFPISVSSILVF 732
            L G++ ++  + N+  + A +       V   FL S+ VA+L +  +         I+   ++    C  W  +D +  N  +++LL  S D YL +  P +Y          L +   W +S V     +   Q    + T+ D  CFI   S P      ++  F  P+++  +L +
Sbjct:   18 LTGIVSLLTIVGNILVMVAFKVNRQLKTVNNYFLLSLAVADLIIGVVSMNLYTTYIIMSRWALGQAACDLWLVVDYVASNASVMNLLVISFDRYLSITRPLKYKAKRTTKRVALMIGLAWVVSLVLWGPAILFWQYVDGKRTVPDNECFIQFLSVPAITFGTAIAAFYLPVTIMMVLYW 196

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BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
Match: htr2cl1 (5-hydroxytryptamine receptor 2C-like [Source:NCBI gene;Acc:101165845])

HSP 1 Score: 70.4774 bits (171), Expect = 2.504e-12
Identity = 51/183 (27.87%), Postives = 93/183 (50.82%), Query Frame = 1

Query:  184 NNNFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISV 714
            + N+P  L+L  + + I   IL + A+   + L + T     FL S+ VA++ +  +  P  +I+ +   +  +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +   +K++A WT+S   S     I  ++E  +  DG C +++  F+++ S + F  P+ +
Sbjct:   73 DKNWPALLILFIIALTIGGNILVILAVSLEKKLQNATNF---FLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---MKIAAVWTISIGVSMPIPVIGLLNEDKVFVDGSCVLNEERFMLIGSFVAFFIPLVI 249

[Close]

Query:  184 NNNFPVNLLLAGVIIVIAW-ILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTI-QDGVCFISDPNFLILRSVMCFGFPISV 714
            + N+P  L+L  + + I   IL + A+   + L + T     FL S+ VA++ +  +  P  +I+ +   +  +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK +   +K++A WT+S   S     I  ++E  +  DG C +++  F+++ S + F  P+ +
Sbjct:   73 DKNWPALLILFIIALTIGGNILVILAVSLEKKLQNATNF---FLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCPIWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAM---MKIAAVWTISIGVSMPIPVIGLLNEDKVFVDGSCVLNEERFMLIGSFVAFFIPLVI 249

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
Match: htr2aa (5-hydroxytryptamine receptor 2A [Source:NCBI gene;Acc:101173822])

HSP 1 Score: 62.7734 bits (151), Expect = 5.802e-10
Identity = 51/189 (26.98%), Postives = 91/189 (48.15%), Query Frame = 1

Query:  205 LLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKIL-VSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP---SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDG-VCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSS 756
            +L+   + V+  IL + A+   + L + T     FL S+ VA++ L  +  P  +++ +      +   +C  W YLD L     I+HL   SLD Y+ +R+P   SR+   TK     +K+ A WT+S   S     +     S +  G  C ++D NF+++ S + F  P+++  +  FL   +L +
Sbjct:   94 ILVVIAVTVMGNILVILAVSLEKKLQNATNY---FLMSLAVADMLLGILVMPVSMVTILYDYRWPLPPDLCPIWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSHTK---ARIKIMAVWTISAGISMPIPVLGLRDHSKVFKGDSCLLTDNNFVLVGSFVAFFVPLTIMVVTYFLTINALQN 276

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
Match: ENSORLT00000000867.2 (alpha-1A adrenergic receptor-like [Source:NCBI gene;Acc:101159125])

HSP 1 Score: 60.077 bits (144), Expect = 4.138e-9
Identity = 56/206 (27.18%), Postives = 94/206 (45.63%), Query Frame = 1

Query:  199 VNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFI-SDPNFLILRSVMCFGFPISVSSIL---VFLAAKSLSSFDRKLQTYKSKEKKED 804
            +   +AG I+VI     LS +C  R L S T     F+ ++ +A+L L+T   P     ++L       I C  W  +D L C   I+ L   S+D Y+ +R+P +Y     +    L +   W LSFV S   + +      +  D VC I ++P + +  S+  F  P+ V   +   V++ AK  +   R L+    K++ E+
Sbjct:   62 IAFAIAGNILVI-----LSVVCN-RHLRSPTNY---FIINLAIADLLLSTTVLPVSATLEVLDYWVFGRIFCDIWAAVDVLCCTASIMSLCVISIDRYIGVRYPLQYPMIVTKRRALLAMLGVWILSFVISIGPL-LGWKEPPSQDDTVCLITAEPFYALFSSLGSFYIPLGVILAMYCRVYVVAKRTT---RNLEAGMMKDRAEN 254

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
Match: drd2a (dopamine receptor D2 [Source:NCBI gene;Acc:101164579])

HSP 1 Score: 58.5362 bits (140), Expect = 1.284e-8
Identity = 51/207 (24.64%), Postives = 102/207 (49.28%), Query Frame = 1

Query:  187 NNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHP----SRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEK 795
            N + + L L   +IV   +L   A+   ++L + T  +   + S+ VA+L +AT+  P  +  +++       I C  +  LD ++C   IL+L   S+D Y  +  P    +RY  S+++ +T + +S  W +SF  S   +     + +T  + +C I++P F++  S++ F  P  + ++LV++    +    RK    K K++
Sbjct:   33 NYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYL---IVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRY--SSRRRVTVM-ISVVWVMSFAISCPLL-FGLNNTATRDESLCVIANPAFVVYSSIVSFYVPF-IITLLVYVQIYVVLRKRRKRVNTKPKQR 231

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Match: SMESG000031149.1 (SMESG000031149.1)

HSP 1 Score: 1017.68 bits (2630), Expect = 0.000e+0
Identity = 517/518 (99.81%), Postives = 518/518 (100.00%), Query Frame = 1

Query:  160 MPRIYVGDNNNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCXXXXXXXXXXXXXXLIQGVCKPPFCILPISNSRINEFKWLSYVLCVIYPLVILIIDRDIRKVIRSSLNC 1713
            MPRIYVGDNNNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCIISIIFWGPFIIGSLIQGVCKPPFCILPISNSRINEFKWLSYVLC+IYPLVILIIDRDIRKVIRSSLNC
Sbjct:    1 MPRIYVGDNNNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCIISIIFWGPFIIGSLIQGVCKPPFCILPISNSRINEFKWLSYVLCIIYPLVILIIDRDIRKVIRSSLNC 518

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Match: SMESG000031149.1 (SMESG000031149.1)

HSP 1 Score: 993.801 bits (2568), Expect = 0.000e+0
Identity = 506/508 (99.61%), Postives = 507/508 (99.80%), Query Frame = 1

Query:  190 NFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCXXXXXXXXXXXXXXLIQGVCKPPFCILPISNSRINEFKWLSYVLCVIYPLVILIIDRDIRKVIRSSLNC 1713
             FPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCIISIIFWGPFIIGSLIQGVCKPPFCILPISNSRINEFKWLSYVLC+IYPLVILIIDRDIRKVIRSSLNC
Sbjct:    2 QFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCIISIIFWGPFIIGSLIQGVCKPPFCILPISNSRINEFKWLSYVLCIIYPLVILIIDRDIRKVIRSSLNC 509

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Match: SMESG000077254.1 (SMESG000077254.1)

HSP 1 Score: 176.792 bits (447), Expect = 1.571e-48
Identity = 156/515 (30.29%), Postives = 247/515 (47.96%), Query Frame = 1

Query:  172 YVGDNNNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAFLSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPI-DRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCXXXXXXXXXXXXXXLIQGVCKPPFCILPISNSRINEFKWLSYVLCVIYPLVILIIDRDIRKVIRSSLNC 1713
            Y  +   FP++L+ A  I+  AWILN+  +  +R   +   + Y ++ S+C++N+ LAT + P  II    +    +  +C    YLD+ LCN ++L LL  ++D + R+R+   Y  S + I   LK  APW +  +Q+   + I+   +  I + VC ++DPNF+I+RS++ F  P+  S+I +F+ AK LS    KL   KS +  E+I+  E   F +  P++        +   LR  D        +T           H CPQHG+L+ P+ ++S ++F               PS  ++YQC +      +P+              S +KH PD++ +     + PIS             +HQ +             +  PS ++       NQ I +    +  I K   +  K +   R   + +I INLSLCII I+FWGP+I  +LIQG+C  P C L IS  +INEFKWLSY   VI PL IL++D  +R+     L C
Sbjct:   15 YSNNKIKFPLDLICAIGIMFCAWILNIIIMVLIRKKRTIEDIKYHYIRSLCISNMILATFNIPVSIIEDFTLLNEQRTTVCFISVYLDSFLCNQIMLLLLCNTIDCFFRIRNSQLYKLSNRPIPFYLKYFAPWLICIIQTITLITISVQYKCEIINHVCVLADPNFIIIRSILGFAIPLITSAIFIFITAKVLSDIRSKLDL-KSDKDFENIL-PEIPLFSV--PQYRCTVGTANENIRLRQLD-------FETVPEETEAKLVQHHCPQHGLLTFPLQEKSGNLF-------------FEPS-SVVYQCSN------QPT--------------SSSKHSPDIVLSSNQDFTKPIS------------MLHQDQPKE----------SQTPSAAI-------NQEILQCADKEFTINK--QNFNKRIEEFRQERKNSI-INLSLCIILIMFWGPYITSTLIQGICILPNCPLSISIPKINEFKWLSYSSSVIIPLFILVMDNRVRRTFCYILRC 452

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Match: SMESG000063199.1 (SMESG000063199.1)

HSP 1 Score: 107.457 bits (267), Expect = 6.193e-25
Identity = 121/439 (27.56%), Postives = 195/439 (44.42%), Query Frame = 1

Query:  430 LDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGVCFISDPNFLILRSVMCFGFPISV--------SSILVFLAAKSLSSFDRKLQTY---KSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDPNTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDPFIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPTMQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLDFQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSH--ERTTIAINLSLCXXXXXXXXXXXXXXLIQGVCKPPFCILPISNSRINEFKWLSYVLCVIYPLVILIIDRDIRKVIRSSL 1707
            ++T LCN+  LH+L  SLD++ RL++P  Y+DS +   T LK+SAPW ++ +Q+   M I      + +  +C I+D NFLILRSV+ +  P+ V           L FL + S+ + D  L++Y   K  +K E   T +   F+  S  +N IN D  +E I  T+   N++   Q                    L+  +     +  N S + K++              C     I  P V+ EN               P +I    +S      N L+ NS     N+H+S S        P    +  S          ++ IP+    K      +  +T   + +R +  E+ +IAIN+ +CIISI  W P I+ +L   +C+   C + IS  RIN+F+W ++   + YP + L +D  IRK ++S L
Sbjct:    1 MNTFLCNLAFLHVLCSSLDTFFRLKNPRLYLDSQRPQTTFLKVSAPWIVTTIQAACQMTINNQKNISTKYSLCLINDGNFLILRSVISYAVPLVVCVILIILQIIYLRFLNSVSVVNLDFLLRSYSINKVNDKCESDETCQLNDFEN-SQSNNEINED--EEMISPTNPVDNSISMEQ--------------------LNQSLQSPKLLSSNPSRILKHN--------------CPKHGLITFPIVIQEN---------------PQIIDLTSTS------NLLMMNSERSKSNLHKSVSF-----EMPDITNMAKS----------SETIPDPRFNKDS----NKYLTNKKSWLRMYKTEQLSIAINMIMCIISIGVWSPLILSTLAYKLCEESPCTIYISVDRINDFEWWAFAGGLAYPCIFLFVDSTIRKSLKSYL 362

[Close]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Match: SMESG000039485.1 (SMESG000039485.1)

HSP 1 Score: 81.2629 bits (199), Expect = 5.468e-16
Identity = 59/185 (31.89%), Postives = 97/185 (52.43%), Query Frame = 1

Query:  301 YAFLSSMCVANLFLATIDFPPPIISKI----LVSTSMQHIMCVSWTYLDTLLCNVLILHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAIAQISESTIQDGV--CFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSFDRKLQTYKSKEKKEDIMTTEAETFQL 837
            Y F+ S+ VAN+    + F PPII         +  +  + C+    ++T+ CN+  LH+L  SLD++LRL  P  Y+ S +     LK+SAPW ++ +Q+   ++I+  S+ +++  +  C I D NFLILRSV+ F  P+    IL  L       F RKL ++ + E    + +T     +L
Sbjct:   70 YYFIVSISVANIL--AVSFNPPIIIVFRWLNFNNNPLWKVYCLIEISINTIFCNLAFLHILFSSLDTFLRLYSPKMYIYSQRPSTNVLKISAPWVVTCIQAGCQLSIS--SKDSLRSRLLHCLIDDVNFLILRSVISFAVPLLACVILTILQLY----FLRKL-SHITDETMRHLFSTYLYNLEL 245

The following BLAST results are available for this feature:

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Human
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Mouse
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Yeast
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Nematostella
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HTR2A	5.359e-13	29.41	5-hydroxytryptamine receptor 2A [Source:HGNC Symbo...	[more]
HTR2A	5.359e-13	29.41	5-hydroxytryptamine receptor 2A [Source:HGNC Symbo...	[more]
HTR2A	5.888e-11	33.90	5-hydroxytryptamine receptor 2A [Source:HGNC Symbo...	[more]
HTR2C	5.922e-9	26.90	5-hydroxytryptamine receptor 2C [Source:HGNC Symbo...	[more]
HTR2C	5.922e-9	26.90	5-hydroxytryptamine receptor 2C [Source:HGNC Symbo...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ser-1	9.919e-8	25.42	SERotonin/octopamine receptor family; Serotonin re...	[more]
ser-1	1.168e-7	25.42	SERotonin/octopamine receptor family; Serotonin re...	[more]
ser-7	9.142e-7	26.29	SERotonin/octopamine receptor family [Source:UniP...	[more]
ser-7	9.464e-7	26.29	SERotonin/octopamine receptor family [Source:UniP...	[more]
ser-7	1.391e-6	26.29	SERotonin/octopamine receptor family [Source:UniP...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
5-HT2B	8.543e-13	29.87	gene:FBgn0261929 transcript:FBtr0303603	[more]
5-HT2B	8.543e-13	29.87	gene:FBgn0261929 transcript:FBtr0339322	[more]
5-HT2B	8.800e-13	29.87	gene:FBgn0261929 transcript:FBtr0330144	[more]
5-HT2A	2.065e-7	24.29	gene:FBgn0087012 transcript:FBtr0078854	[more]
5-HT2A	2.207e-7	24.29	gene:FBgn0087012 transcript:FBtr0300474	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
htr2aa	9.949e-13	28.16	5-hydroxytryptamine (serotonin) receptor 2A, genom...	[more]
htr2ab	3.576e-11	28.42	5-hydroxytryptamine (serotonin) receptor 2A, genom...	[more]
htr2cl1	7.398e-11	27.43	5-hydroxytryptamine (serotonin) receptor 2C, G pro...	[more]
htr2cl1	7.478e-11	27.43	5-hydroxytryptamine (serotonin) receptor 2C, G pro...	[more]
htr2cl1	7.478e-11	27.43	5-hydroxytryptamine (serotonin) receptor 2C, G pro...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
slc25a29	3.194e-12	30.77	solute carrier family 25 (mitochondrial carnitine/...	[more]
slc25a29	3.620e-12	30.77	solute carrier family 25 (mitochondrial carnitine/...	[more]
slc25a29	3.965e-12	30.77	solute carrier family 25 (mitochondrial carnitine/...	[more]
slc25a29	4.153e-12	30.93	solute carrier family 25 (mitochondrial carnitine/...	[more]
HTR2C	4.691e-9	25.93	5-hydroxytryptamine (serotonin) receptor 2C, G pro...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Htr2a	4.749e-13	29.41	5-hydroxytryptamine (serotonin) receptor 2A [Sourc...	[more]
Htr2c	5.261e-11	25.82	5-hydroxytryptamine (serotonin) receptor 2C [Sourc...	[more]
Htr2c	5.261e-11	25.82	5-hydroxytryptamine (serotonin) receptor 2C [Sourc...	[more]
Adra1a	3.761e-9	25.89	adrenergic receptor, alpha 1a [Source:MGI Symbol;A...	[more]
Adra1a	3.761e-9	25.89	adrenergic receptor, alpha 1a [Source:MGI Symbol;A...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q75Z89\|5HT2A_BOVIN	1.580e-12	29.41	5-hydroxytryptamine receptor 2A OS=Bos taurus OX=9...	[more]
sp\|O46635\|5HT2A_CANLF	1.772e-12	29.41	5-hydroxytryptamine receptor 2A OS=Canis lupus fam...	[more]
sp\|P18599\|5HT2A_CRIGR	2.295e-12	29.41	5-hydroxytryptamine receptor 2A OS=Cricetulus gris...	[more]
sp\|Q5R4Q6\|5HT2A_PONPY	2.574e-12	29.41	5-hydroxytryptamine receptor 2A OS=Pongo pygmaeus ...	[more]
sp\|P50128\|5HT2A_MACMU	2.574e-12	29.41	5-hydroxytryptamine receptor 2A OS=Macaca mulatta ...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8H2Q9	8.645e-27	39.74	G_PROTEIN_RECEP_F1_2 domain-containing protein OS=...	[more]
A0A4E0RHB5	3.022e-24	31.61	G_PROTEIN_RECEP_F1_2 domain-containing protein OS=...	[more]
A0A1I8GR39	3.443e-22	48.94	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8ICS2	5.649e-22	48.94	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A4E0RCP4	2.782e-21	33.33	G_PROTEIN_RECEP_F1_2 domain-containing protein OS=...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
htr2ab	8.994e-14	28.00	5-hydroxytryptamine (serotonin) receptor 2A, genom...	[more]
htr2cl2	7.545e-13	24.08	5-hydroxytryptamine (serotonin) receptor 2C, G pro...	[more]
drd2b	2.360e-10	27.14	D(2) dopamine receptor A [Source:NCBI gene;Acc:103...	[more]
drd2b	2.838e-10	27.14	D(2) dopamine receptor A [Source:NCBI gene;Acc:103...	[more]
drd2b	2.959e-10	27.14	D(2) dopamine receptor A [Source:NCBI gene;Acc:103...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000004593.1	1.198e-9	29.11	pep scaffold:Pmarinus_7.0:GL476854:168999:207459:1...	[more]
chrm5b	5.508e-7	21.30	cholinergic receptor, muscarinic 5b [Source:ZFIN;A...	[more]
ENSPMAT00000009127.1	9.258e-7	24.60	pep scaffold:Pmarinus_7.0:GL478629:43196:44446:-1 ...	[more]
ENSPMAT00000006953.1	2.906e-6	28.06	pep scaffold:Pmarinus_7.0:GL477632:7596:14007:1 ge...	[more]
CHRM3	3.042e-6	21.79	cholinergic receptor muscarinic 3 [Source:HGNC Sym...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
htr2cl1	2.504e-12	27.87	5-hydroxytryptamine receptor 2C-like [Source:NCBI ...	[more]
htr2cl1	2.504e-12	27.87	5-hydroxytryptamine receptor 2C-like [Source:NCBI ...	[more]
htr2aa	5.802e-10	26.98	5-hydroxytryptamine receptor 2A [Source:NCBI gene;...	[more]
ENSORLT00000000867.2	4.138e-9	27.18	alpha-1A adrenergic receptor-like [Source:NCBI gen...	[more]
drd2a	1.284e-8	24.64	dopamine receptor D2 [Source:NCBI gene;Acc:1011645...	[more]

BLAST of 5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000031149.1	0.000e+0	99.81	SMESG000031149.1	[more]
SMESG000031149.1	0.000e+0	99.61	SMESG000031149.1	[more]
SMESG000077254.1	1.571e-48	30.29	SMESG000077254.1	[more]
SMESG000063199.1	6.193e-25	27.56	SMESG000063199.1	[more]
SMESG000039485.1	5.468e-16	31.89	SMESG000039485.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013958 ID=SMED30013958|Name=5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled|organism=Schmidtea mediterranea sexual|type=transcript|length=1945bp
TATTTTTAATAAATCAATTTTCTATATTTTAATAATTGAATGTTATTTAT
CTAAAGCAATTTTTCAGTACTGCCTTTTTCAATTGTTTAAAAAATATTGA
AGACAAATCGCTCGTGGAAAAACTGAAAGTTTGCTCTGAGATGGTAATTT
TTCTGCTCGATGCCAAGGATTTATGTTGGTGACAATAATAATTTCCCTGT
CAATCTTCTACTTGCCGGTGTCATAATAGTTATTGCTTGGATCTTGAATT
TATCAGCGATTTGTGCAATGAGGTCTCTCAATTCTGGTACAAGGGTCGTT
TATGCATTTCTCAGTTCAATGTGCGTTGCCAACCTCTTTTTGGCCACGAT
AGATTTTCCACCACCTATTATATCAAAAATATTAGTATCAACGTCTATGC
AGCATATTATGTGTGTATCCTGGACTTATTTGGACACTTTGCTATGTAAT
GTTCTCATCCTGCATCTTCTTGGGTGCAGTCTGGACTCATATTTACGTCT
TCGTCATCCATCTCGATACATGGATTCCACAAAGCAAATATTAACTTGCC
TTAAACTGTCTGCACCATGGACTTTAAGTTTCGTTCAGTCGACAGCTTTT
ATGGCCATTGCTCAGATTTCAGAATCTACTATTCAAGACGGTGTTTGCTT
TATATCTGATCCCAATTTCTTGATTCTTCGTTCGGTTATGTGTTTTGGAT
TTCCTATCTCAGTTAGTTCAATATTAGTATTTCTTGCTGCCAAAAGTCTT
TCTTCATTTGACAGAAAACTACAAACCTATAAATCTAAAGAAAAGAAAGA
AGATATTATGACAACTGAAGCGGAAACATTTCAACTACTTTCTCCTAGGC
ATAATTTAATCAACAGAGATGAAACTCAAGAAACTATTTTGCGAACGTCA
GACGATCCGAATACTGTAGTCTCTTCTCAGACATTTGATTGTACCAATAC
ACTAAACTATTATCATCATCAGTGTCCTCAACATGGAATTCTTTCCATTC
CTATTGACCGAAGTGCCCATATTTTTCCGAATTCGAGCCATGTTTCTAAA
TATGATCCATTCATTATGAGTCCATCTTGTGACATACTATATCAGTGTTG
TTCAACACAAGCAGCAATTAAAGAGCCATCGGTTCTTTCTGAAAATGTTT
ATACTTCAAATTATATTTATCCTTCCGACACCAAACACTGTCCTGATGTT
ATTCCAACTATGCAGTCCTCCACTAGCGATCCCATTTCAAATCCTTTAGT
GAATAATTCCATTTTGAGGAATCCAAATATGCATCAATCTAGATCGTCAG
GAGACATTCTAGATTCACATCCTCATTACTGTACACTTCCGCCAAGTCAA
TCTTTGGACTTTCAAAGAATATATGAAAATCAAATAATCCCAGAAACAAA
TGTTACAAAATCTCATATTGAAAAACCTTCGGCTTCAATAACAAAACCCC
TAAATCTTGTAAGATCTCATGAACGCACGACGATAGCGATTAATTTATCT
CTTTGCATTATCTCAATTATATTTTGGGGACCATTTATTATTGGATCATT
AATCCAGGGAGTATGCAAACCCCCTTTTTGTATTTTACCCATTTCTAATT
CTCGTATCAATGAATTCAAGTGGTTATCTTATGTTCTTTGCGTTATATAT
CCATTAGTTATACTAATCATTGATAGAGACATTCGTAAAGTGATCAGGTC
TTCATTAAATTGTTGAATTATAGGATTGTCAAATTTGATGACTCGAATAA
ATTTTGCATAAATTTGTAAGTTTTAAATTATAATCAAAACGAAAGTTTTG
TGTTTTTTGATATCATTTATTATCCGTCTAGGTCCTTTTCAAAGTTTCAA
ATTATCTGTCTTTTACTTCTTTAATCTAATTCGAATAGTGATCAAATTGT
TTCAATAGAAAAGATTATATGCTTACCATACTTCATGAATTTTGT

protein sequence of SMED30013958-orf-1

>SMED30013958-orf-1 ID=SMED30013958-orf-1|Name=SMED30013958-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=519bp
MPRIYVGDNNNFPVNLLLAGVIIVIAWILNLSAICAMRSLNSGTRVVYAF
LSSMCVANLFLATIDFPPPIISKILVSTSMQHIMCVSWTYLDTLLCNVLI
LHLLGCSLDSYLRLRHPSRYMDSTKQILTCLKLSAPWTLSFVQSTAFMAI
AQISESTIQDGVCFISDPNFLILRSVMCFGFPISVSSILVFLAAKSLSSF
DRKLQTYKSKEKKEDIMTTEAETFQLLSPRHNLINRDETQETILRTSDDP
NTVVSSQTFDCTNTLNYYHHQCPQHGILSIPIDRSAHIFPNSSHVSKYDP
FIMSPSCDILYQCCSTQAAIKEPSVLSENVYTSNYIYPSDTKHCPDVIPT
MQSSTSDPISNPLVNNSILRNPNMHQSRSSGDILDSHPHYCTLPPSQSLD
FQRIYENQIIPETNVTKSHIEKPSASITKPLNLVRSHERTTIAINLSLCI
ISIIFWGPFIIGSLIQGVCKPPFCILPISNSRINEFKWLSYVLCVIYPLV
ILIIDRDIRKVIRSSLNC*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR000276	GPCR_Rhodpsn
IPR017452	GPCR_Rhodpsn_7TM

Vocabulary: **molecular function**
Term	Definition
GO:0004930	G-protein coupled receptor activity
GO:0004871	signal transducer activity
GO:0004993	G-protein coupled serotonin receptor activity

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043198	dendritic shaft

Vocabulary: **biological process**
Term	Definition
GO:0007186	G-protein coupled receptor signaling pathway
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0046883	regulation of hormone secretion
GO:0050795	regulation of behavior
GO:0098664	G-protein coupled serotonin receptor signaling pathway

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000276	G protein-coupled receptor, rhodopsin-like	PFAM	PF00001	7tm_1	coord: 30..499 e-value: 9.3E-21 score: 74.3
None	No IPR available	GENE3D	G3DSA:1.20.120.10		coord: 202..260 e-value: 2.1E-19 score: 72.0
None	No IPR available	GENE3D	G3DSA:1.20.1070.10		coord: 22..201 e-value: 2.1E-19 score: 72.0
None	No IPR available	PANTHER	PTHR24247:SF198	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED	coord: 18..516
None	No IPR available	PANTHER	PTHR24247	5-HYDROXYTRYPTAMINE RECEPTOR	coord: 18..516
None	No IPR available	CDD	cd15307	7tmA_5-HT2_insect-like	coord: 17..198 e-value: 9.38896E-18 score: 81.5366
None	No IPR available	SUPERFAMILY	SSF81321	Family A G protein-coupled receptor-like	coord: 14..518
None	No IPR available	TMHMM	TMhelix		coord: 49..71
None	No IPR available	TMHMM	TMhelix		coord: 170..192
None	No IPR available	TMHMM	TMhelix		coord: 486..504
None	No IPR available	TMHMM	TMhelix		coord: 15..37
None	No IPR available	TMHMM	TMhelix		coord: 128..150
None	No IPR available	TMHMM	TMhelix		coord: 86..108
None	No IPR available	TMHMM	TMhelix		coord: 444..466
IPR017452	GPCR, rhodopsin-like, 7TM	PROSITE	PS50262	G_PROTEIN_RECEP_F1_2	coord: 20..192 score: 10.101

Main menu

5-hydroxytryptamine (Serotonin) receptor 2A, G protein-coupled

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

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