Chloride intracellular channel 4

Overview
NameChloride intracellular channel 4
Smed IDSMED30013924
Length (bp)988
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Chloride intracellular channel 4 (SMED30013924) t-SNE clustered cells

Violin plots show distribution of expression levels for Chloride intracellular channel 4 (SMED30013924) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Chloride intracellular channel 4 (SMED30013924) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Chloride intracellular channel 4 (SMED30013924) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013924

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30013924h1SMcG0012197 dd_Smed_v4_13202_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30013924h1SMcG0012197 dd_Smed_v4_13202_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30013924h1SMcG0012197 dd_Smed_v6_13202_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 75.485 bits (184), Expect = 3.041e-15
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 75.485 bits (184), Expect = 3.041e-15
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 75.485 bits (184), Expect = 3.041e-15
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 75.485 bits (184), Expect = 3.041e-15
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 75.485 bits (184), Expect = 3.041e-15
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exc-4 (Chloride intracellular channel exc-4 [Source:UniProtKB/Swiss-Prot;Acc:Q8WQA4])

HSP 1 Score: 115.161 bits (287), Expect = 9.717e-30
Identity = 78/262 (29.77%), Postives = 131/262 (50.00%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDD-IGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTN----------------------NFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNS 850
            KPLLELYVK S  +   IG+   CQ ++M LY L +     ++V  VNV++   ++K+  +G + P+        +I+ + E+   +       ++ L K +   L  ++      AE    +LYR+FK+FL                         ++N+    L  +D   +   S++L+G+ ++  DCELMP+L HIRI  + L   D+  N  H+  YI   Y   AFI+SCP+D++II HY++ +N+  +Q + L S
Sbjct:   16 KPLLELYVKASGIDARRIGADLFCQEFWMELYALYEIGVARVEVKTVNVNS--EAFKKNFLGAQPPI--------MIEEEKELTYTDNREIEGRIFHLAKEFNVPLFEKDP----SAEKRIENLYRNFKLFLRAKVEFDKGKKEPSRVEDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLHHIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMNLFTNQRETLQS 263
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exl-1 (Chloride intracellular channel exl-1 [Source:UniProtKB/Swiss-Prot;Acc:O45405])

HSP 1 Score: 85.5001 bits (210), Expect = 3.255e-19
Identity = 63/244 (25.82%), Postives = 114/244 (46.72%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSC--PICQTWFM-ILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFL--TTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY---RDTLNITVDQLKKL 844
            P   L++   S  +++  C  P     FM  LY    +  +   V   NV+     +K  G+ R++P +      E    ++E          +++ + L+Y K +  ++      EAE +  DL+R F  F+    +    F+  L +LD Y +   +KFL+ D ++  DC ++ +L  IR+   +LK  ++  +L H+  Y+   Y+ E F  SCPSD+ I+LH+   +DT  ++     KL
Sbjct:    2 PTFSLWLPAGS--NNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGL-RRMPGISAEESGETQTFETE----------DDILDFLEYLKPERGDDE-----EAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exl-1 (Chloride intracellular channel exl-1 [Source:UniProtKB/Swiss-Prot;Acc:O45405])

HSP 1 Score: 85.5001 bits (210), Expect = 3.255e-19
Identity = 63/244 (25.82%), Postives = 114/244 (46.72%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSC--PICQTWFM-ILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFL--TTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY---RDTLNITVDQLKKL 844
            P   L++   S  +++  C  P     FM  LY    +  +   V   NV+     +K  G+ R++P +      E    ++E          +++ + L+Y K +  ++      EAE +  DL+R F  F+    +    F+  L +LD Y +   +KFL+ D ++  DC ++ +L  IR+   +LK  ++  +L H+  Y+   Y+ E F  SCPSD+ I+LH+   +DT  ++     KL
Sbjct:    2 PTFSLWLPAGS--NNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGL-RRMPGISAEESGETQTFETE----------DDILDFLEYLKPERGDDE-----EAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Match: Clic (gene:FBgn0030529 transcript:FBtr0346089)

HSP 1 Score: 99.7525 bits (247), Expect = 3.714e-24
Identity = 67/229 (29.26%), Postives = 120/229 (52.40%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDI-GSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFL--DLYRDFKIFLTTNNF---NKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYR 805
            P +EL +K S+ +    G+C  CQ +FM LY L +   I L+VT V++  P   ++        P++ I +G  ++  ++E + ++ + +    Y L               + + E + L  +LY   K+ L   +    N    +L+K++D+ +  N++FL GD +   DCELMP+LQHIR+      + ++  +L  +  Y+  MY ++AF QSCP+D++II HY+
Sbjct:   21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPPIL-IDNGLAIL--ENEKIERHIMKNIPGGYNLF--------------VQDKEVATLIENLYVKLKLMLVKKDEAKNNALLSHLRKINDHLSARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHYK 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Match: Clic (gene:FBgn0030529 transcript:FBtr0073835)

HSP 1 Score: 99.7525 bits (247), Expect = 3.714e-24
Identity = 67/229 (29.26%), Postives = 120/229 (52.40%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDI-GSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFL--DLYRDFKIFLTTNNF---NKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYR 805
            P +EL +K S+ +    G+C  CQ +FM LY L +   I L+VT V++  P   ++        P++ I +G  ++  ++E + ++ + +    Y L               + + E + L  +LY   K+ L   +    N    +L+K++D+ +  N++FL GD +   DCELMP+LQHIR+      + ++  +L  +  Y+  MY ++AF QSCP+D++II HY+
Sbjct:   21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPPIL-IDNGLAIL--ENEKIERHIMKNIPGGYNLF--------------VQDKEVATLIENLYVKLKLMLVKKDEAKNNALLSHLRKINDHLSARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHYK 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 73.9442 bits (180), Expect = 6.695e-15
Identity = 60/240 (25.00%), Postives = 102/240 (42.50%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFH-----YYLKKLDDYF------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL++K     +++G+CP CQ  FM+L+       +   VT V++    +  K L  G   P + + +G          ++ +FI     L   L   +   L   S +  E+     D++  F  F+  +  N FH        K+LDDY             ++   KFL G+ +++ DC L+PKL  I++        D+      +  Y+   Y  E F Q+CP+D  I   Y
Sbjct:   10 EPRIELFIKAGHDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNG---------TLKTDFIKIEEFLETTLAPPRYPHL---SPRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEIEKAY 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 73.9442 bits (180), Expect = 6.695e-15
Identity = 60/240 (25.00%), Postives = 102/240 (42.50%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFH-----YYLKKLDDYF------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL++K     +++G+CP CQ  FM+L+       +   VT V++    +  K L  G   P + + +G          ++ +FI     L   L   +   L   S +  E+     D++  F  F+  +  N FH        K+LDDY             ++   KFL G+ +++ DC L+PKL  I++        D+      +  Y+   Y  E F Q+CP+D  I   Y
Sbjct:   10 EPRIELFIKAGHDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNG---------TLKTDFIKIEEFLETTLAPPRYPHL---SPRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEIEKAY 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 73.9442 bits (180), Expect = 6.695e-15
Identity = 60/240 (25.00%), Postives = 102/240 (42.50%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFH-----YYLKKLDDYF------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL++K     +++G+CP CQ  FM+L+       +   VT V++    +  K L  G   P + + +G          ++ +FI     L   L   +   L   S +  E+     D++  F  F+  +  N FH        K+LDDY             ++   KFL G+ +++ DC L+PKL  I++        D+      +  Y+   Y  E F Q+CP+D  I   Y
Sbjct:   10 EPRIELFIKAGHDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNG---------TLKTDFIKIEEFLETTLAPPRYPHL---SPRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEIEKAY 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: pnpla7a (patatin-like phospholipase domain containing 7a [Source:ZFIN;Acc:ZDB-GENE-070112-1812])

HSP 1 Score: 71.633 bits (174), Expect = 4.061e-14
Identity = 61/242 (25.21%), Postives = 104/242 (42.98%), Query Frame = 2 
Query:  143 LELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK-YWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFN-------KFHYYLKKLDDYF--------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +EL+VK S   + +G+CP CQ  FMIL+ L   NF    +T V++       K L  G + P + I +G+   D              N++ E L+         +   +  E+  +  D++  F  ++   N         KF   L KLD Y               +     +L G+ +S+ DC L+PKL  +++ C   +  ++   L  +  Y++K Y  + F  +CP D+ I+L Y
Sbjct:    7 IELFVKASDDGESVGNCPFCQRLFMILW-LKGVNFT---LTTVDMKRAPEVLKDLAPGSQPPFL-IYNGEVRTDT-------------NKIEEFLEDTLAPPQYPKLCCRYKESNTAGDDIFHKFSAYIKNPNPGLNDMLEKKFLKSLMKLDQYLLTPLPHELDQNPELSTSTRHYLDGNALSLADCNLLPKLHIVKVVCKKYRGFEIPAELKGLSKYLDKAYKEDVFHLTCPKDKEILLAY 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic3 (chloride intracellular channel 3 [Source:ZFIN;Acc:ZDB-GENE-010507-2])

HSP 1 Score: 71.633 bits (174), Expect = 4.061e-14
Identity = 61/242 (25.21%), Postives = 104/242 (42.98%), Query Frame = 2 
Query:  143 LELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK-YWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFN-------KFHYYLKKLDDYF--------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +EL+VK S   + +G+CP CQ  FMIL+ L   NF    +T V++       K L  G + P + I +G+   D              N++ E L+         +   +  E+  +  D++  F  ++   N         KF   L KLD Y               +     +L G+ +S+ DC L+PKL  +++ C   +  ++   L  +  Y++K Y  + F  +CP D+ I+L Y
Sbjct:    7 IELFVKASDDGESVGNCPFCQRLFMILW-LKGVNFT---LTTVDMKRAPEVLKDLAPGSQPPFL-IYNGEVRTDT-------------NKIEEFLEDTLAPPQYPKLCCRYKESNTAGDDIFHKFSAYIKNPNPGLNDMLEKKFLKSLMKLDQYLLTPLPHELDQNPELSTSTRHYLDGNALSLADCNLLPKLHIVKVVCKKYRGFEIPAELKGLSKYLDKAYKEDVFHLTCPKDKEILLAY 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: clic4 (chloride intracellular channel 5 [Source:NCBI gene;Acc:493290])

HSP 1 Score: 73.1738 bits (178), Expect = 2.025e-14
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query:  140 LLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHY-------YLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            L+EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +            +  V+ +       L E+L   K + L   + K  E+  + +D++  F  ++  +  +            L+KLDDY                 T  N KFL G+ +++ DC L+PKL  I++     +  ++ +++  I  Y++  YS + F  +CP DR I + Y D
Sbjct:   17 LVELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTHPPFI----------TYNHEVKTDVNKIEEFLEEVLCPPKYRKL---AAKHPESNTAGMDIFAKFSAYIKNSRPDNNEALERGLLKTLQKLDDYLNSPLPDEIDENSMDDITQSNRKFLDGEEMTLADCNLLPKLHIIKVVTKKYRGFEIPKSMTGIWRYLSNAYSKDEFTNTCPGDREIEIAYAD 245
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: clic1 (chloride intracellular channel 1 [Source:NCBI gene;Acc:394484])

HSP 1 Score: 67.0106 bits (162), Expect = 2.876e-12
Identity = 60/255 (23.53%), Postives = 102/255 (40.00%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL-------KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHY-------YLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            +P +EL+VK ++    IG+CP  Q  FM+L+       +   VT V++    +  K L  G + P + + +G+   D              N++ E L       KY K    N+      E+  + LD++  F  ++  +N              LK LD Y                  + N KFL G+ +++ DC L+PKL  +++ C   +   +      I  Y+   Y  E F  +CP    I+  Y +
Sbjct:    4 QPQVELFVKAANDGQSIGNCPFSQRLFMVLWL----KGVTFNVTTVDMKKKPDILKDLAPGAQPPFL-LFAGEVRTDT-------------NKIEEFLEETLCPPKYPKLACRNQ------ESNTAGLDVFARFSAYIKNSNPAPNQSVEKGLLKALKVLDIYLNTPQIDEIDENSAEDEPVSNRKFLDGNELTLADCNLLPKLNIVQVVCEHFRGFKIPAEFTGIHRYLQNAYKREEFASTCPDAAEIVRAYAE 234
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: st3gal5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Source:Xenbase;Acc:XB-GENE-955106])

HSP 1 Score: 64.6994 bits (156), Expect = 2.032e-11
Identity = 60/251 (23.90%), Postives = 102/251 (40.64%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK-YWKSKLLNENSIKIHEAEFSFLDLYRDFKIFL--TTNNFNK-----FHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P +EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +   +G+   D              N++ E L+         + + K  E+  + +D++  F  ++  T    N          LKKLD Y                  +   KFL GD  ++ DC L+PKL  ++I     +  ++   +  I  Y+   Y+ + F  +C +D+   L Y D
Sbjct:   14 PDIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHN-------LAPGTHPPFL-TFNGEVKTDV-------------NKIEEFLEESLAPPRYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQDNAGLEKGLTKALKKLDTYLNSPLPEEIDANSREEEKVSKRKFLDGDEFTLADCNLLPKLHVVKIVAKKYRNYEIPAEMSGIWRYLKNAYARDEFTNTCAADKETELAYAD 243
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: clic4 (chloride intracellular channel 5 [Source:NCBI gene;Acc:493290])

HSP 1 Score: 63.5438 bits (153), Expect = 4.734e-11
Identity = 58/242 (23.97%), Postives = 102/242 (42.15%), Query Frame = 2 
Query:  161 TSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHY-------YLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
              S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +            +  V+ +       L E+L   K + L   + K  E+  + +D++  F  ++  +  +            L+KLDDY                 T  N KFL G+ +++ DC L+PKL  I++     +  ++ +++  I  Y++  YS + F  +CP DR I + Y D
Sbjct:   17 AGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTHPPFI----------TYNHEVKTDVNKIEEFLEEVLCPPKYRKL---AAKHPESNTAGMDIFAKFSAYIKNSRPDNNEALERGLLKTLQKLDDYLNSPLPDEIDENSMDDITQSNRKFLDGEEMTLADCNLLPKLHIIKVVTKKYRGFEIPKSMTGIWRYLSNAYSKDEFTNTCPGDREIEIAYAD 238
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: CLIC6 (chloride intracellular channel 6 [Source:NCBI gene;Acc:100486547])

HSP 1 Score: 61.6178 bits (148), Expect = 2.099e-10
Identity = 58/242 (23.97%), Postives = 101/242 (41.74%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLY-RDFKIFLTTNNFNKFHYYLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            P + L  +  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +    G+   D       + F+    E   + +Y K    +  S       F+    Y ++ +  L       F   L+KLDD+                 TI + KFL G+ +++ DC L+PKLQ I++     +  ++  ++  I  Y+N  ++ + F  +CP+D  I   Y
Sbjct:    5 PSVCLVPQAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTNPPFM-TFDGEVKTDVNK---IEEFL---EERLTMPRYPKLAPKHPESSSAGNDVFAKFSAYIKNPRKDLNAALEKGFLRSLRKLDDFLNTPLPDEIDAYSTEDITISDRKFLDGNELTLADCNLLPKLQIIKVVAKKYRNFEIPTDMTGIWRYLNSAFARDEFTNTCPADSEIEYAY 232
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic1 (chloride intracellular channel 1 [Source:MGI Symbol;Acc:MGI:2148924])

HSP 1 Score: 77.411 bits (189), Expect = 4.511e-16
Identity = 65/250 (26.00%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  S LD++  F  ++  +N              LK LD+Y T                I   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAMLCPPRYPKLAALNP------ESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic4 (chloride intracellular channel 4 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1352754])

HSP 1 Score: 73.9442 bits (180), Expect = 8.938e-15
Identity = 62/258 (24.03%), Postives = 109/258 (42.25%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL-------KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYY-------LKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            +PL+EL+VK  S  + IG+CP  Q  FMIL+    +     +DL+  P ++ N       L  G   P +   S     + ++++         N++ E L       KY K       S K  E+  + +D++  F  ++  +               L+KLD+Y                      +FL GD +++ DC L+PKL  +++     +  D+ + +  I  Y+   YS + F  +CPSD+ + + Y D
Sbjct:   16 EPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQN-------LAPGTHPPFITFNS-----EVKTDV---------NKIEEFLEEVLCPPKYLKL------SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSD 246
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic5 (chloride intracellular channel 5 [Source:MGI Symbol;Acc:MGI:1917912])

HSP 1 Score: 65.855 bits (159), Expect = 5.210e-12
Identity = 61/254 (24.02%), Postives = 104/254 (40.94%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNEN----SIKIHEAEFSFLDLYRDFKIFLTT----NNF---NKFHYYLKKLDDYFTI----------------CNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P +EL+VK     + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +         D ++++         N++ E L+     L  E     + K  E+  + +D++  F  ++      NN          L+KLDDY                      KFL GD +++ DC L+PKL  ++I     +  D+   +  +  Y+   Y+ + F  +C +D  I L Y D
Sbjct:   14 PEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHN-------LAPGTHPPFLTFNG-----DVKTDV---------NKIEEFLE---ETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYAD 243
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic6 (chloride intracellular channel 6 [Source:MGI Symbol;Acc:MGI:2146607])

HSP 1 Score: 65.0846 bits (157), Expect = 4.129e-11
Identity = 65/252 (25.79%), Postives = 105/252 (41.67%), Query Frame = 2 
Query:  149 LYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIH----EAEFSFLDLYRDFKIFL--TTNNFNKFH-----YYLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTL 814
            L+VK     + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +    G+   D              N++ E L+    KL+     K+     E+  +  D++  F  F+  T  + N+ +       LKKLD Y                 T+   KFL GD +++ DC L+PKL  I+I     ++ +    +  I  Y+N  Y+ + F  +CP+DR I   Y D  
Sbjct:  365 LFVKAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQN-------LAPGTNPPFM-TFDGEVKTDV-------------NKIEEFLE---EKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIYEKNLLRALKKLDSYLNSPLPDEIDADSSEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADREIEHAYSDAA 592
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic5 (chloride intracellular channel 5 [Source:MGI Symbol;Acc:MGI:1917912])

HSP 1 Score: 60.4622 bits (145), Expect = 9.352e-10
Identity = 61/251 (24.30%), Postives = 103/251 (41.04%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVR-KNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTT----NNF---NKFHYYLKKLDDYFTI----------------CNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P + L+VK     + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +         D ++++ + + F      L E L   K   L   + K  E+  + +D++  F  ++      NN          L+KLDDY                      KFL GD +++ DC L+PKL  ++I     +  D+   +  +  Y+   Y+ + F  +C +D  I L Y D
Sbjct:  248 PEIFLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHN-------LAPGTHPPFLTFNG-----DVKTDVNKIEEF------LEETLTPEKYPKL---AAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYAD 477
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q8WQA4|EXC4_CAEEL (Chloride intracellular channel exc-4 OS=Caenorhabditis elegans OX=6239 GN=exc-4 PE=1 SV=2)

HSP 1 Score: 115.161 bits (287), Expect = 1.236e-28
Identity = 78/262 (29.77%), Postives = 131/262 (50.00%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDD-IGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTN----------------------NFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNS 850
            KPLLELYVK S  +   IG+   CQ ++M LY L +     ++V  VNV++   ++K+  +G + P+        +I+ + E+   +       ++ L K +   L  ++      AE    +LYR+FK+FL                         ++N+    L  +D   +   S++L+G+ ++  DCELMP+L HIRI  + L   D+  N  H+  YI   Y   AFI+SCP+D++II HY++ +N+  +Q + L S
Sbjct:   16 KPLLELYVKASGIDARRIGADLFCQEFWMELYALYEIGVARVEVKTVNVNS--EAFKKNFLGAQPPI--------MIEEEKELTYTDNREIEGRIFHLAKEFNVPLFEKDP----SAEKRIENLYRNFKLFLRAKVEFDKGKKEPSRVEDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLHHIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMNLFTNQRETLQS 263
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|O45405|EXL1_CAEEL (Chloride intracellular channel exl-1 OS=Caenorhabditis elegans OX=6239 GN=exl-1 PE=2 SV=2)

HSP 1 Score: 85.5001 bits (210), Expect = 4.140e-18
Identity = 63/244 (25.82%), Postives = 114/244 (46.72%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSC--PICQTWFM-ILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFL--TTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY---RDTLNITVDQLKKL 844
            P   L++   S  +++  C  P     FM  LY    +  +   V   NV+     +K  G+ R++P +      E    ++E          +++ + L+Y K +  ++      EAE +  DL+R F  F+    +    F+  L +LD Y +   +KFL+ D ++  DC ++ +L  IR+   +LK  ++  +L H+  Y+   Y+ E F  SCPSD+ I+LH+   +DT  ++     KL
Sbjct:    2 PTFSLWLPAGS--NNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGL-RRMPGISAEESGETQTFETE----------DDILDFLEYLKPERGDDE-----EAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q9Z1Q5|CLIC1_MOUSE (Chloride intracellular channel protein 1 OS=Mus musculus OX=10090 GN=Clic1 PE=1 SV=3)

HSP 1 Score: 77.411 bits (189), Expect = 3.155e-15
Identity = 65/250 (26.00%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  S LD++  F  ++  +N              LK LD+Y T                I   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAMLCPPRYPKLAALNP------ESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q6MG61|CLIC1_RAT (Chloride intracellular channel protein 1 OS=Rattus norvegicus OX=10116 GN=Clic1 PE=1 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 4.817e-15
Identity = 65/250 (26.00%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  S LD++  F  ++  +N              LK LD+Y T                I   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|O00299|CLIC1_HUMAN (Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4)

HSP 1 Score: 75.485 bits (184), Expect = 1.460e-14
Identity = 63/250 (25.20%), Postives = 106/250 (42.40%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL----KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNF-------NKFHYYLKKLDDYFT----------------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            +P +EL+VK  S    IG+CP  Q  FM+L+       +   VT V+      + ++L  G +LP   ++ G E+    ++I          E  E +    +Y K   LN       E+  + LD++  F  ++  +N              LK LD+Y T                +   KFL G+ +++ DC L+PKL  +++ C   +   + E    +  Y++  Y+ E F  +CP D  I L Y
Sbjct:    5 QPQVELFVKAGSDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPF--LLYGTEVHTDTNKI---------EEFLEAVLCPPRYPKLAALNP------ESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAY 233
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8GES9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011978g2 PE=4 SV=1)

HSP 1 Score: 162.155 bits (409), Expect = 4.283e-44
Identity = 85/250 (34.00%), Postives = 143/250 (57.20%), Query Frame = 2 
Query:  134 KPLLELYVKTSS-CEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSK--LLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNIT-VDQLKKLNSMGNKRLM 871
            KP++EL++K S  C++D G CPI Q WFM+ Y L ++ +++L VT VN D P  +Y+ L +GR LPV ++I G    D +   +      + +E+ +L+  WK     L + S    EAE +F DLY++  + L T N     + L+++D +      +FL+ D ++  DC+LMPKL H+++     ++ DV  +L++++ Y + MY  EAF  SCP+DR++   Y D L    V Q  + + M + R++
Sbjct:   15 KPVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKG---ADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRFLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYHDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8GET5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013060g1 PE=4 SV=1)

HSP 1 Score: 160.999 bits (406), Expect = 1.038e-43
Identity = 85/250 (34.00%), Postives = 143/250 (57.20%), Query Frame = 2 
Query:  134 KPLLELYVKTSS-CEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSK--LLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNIT-VDQLKKLNSMGNKRLM 871
            KP++EL++K S  C++D G CPI Q WFM+ Y L ++ +++L VT VN D P  +Y+ L +GR LPV ++I G    D +   +      + +E+ +L+  WK     L + S    EAE +F DLY++  + L T N     + L+++D +      +FL+ D ++  DC+LMPKL H+++     ++ DV  +L++++ Y + MY  EAF  SCP+DR++   Y D L    V Q  + + M + R++
Sbjct:   15 KPVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKG---ADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRFLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYYDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8G169 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011978g1 PE=4 SV=1)

HSP 1 Score: 159.844 bits (403), Expect = 2.859e-43
Identity = 84/250 (33.60%), Postives = 143/250 (57.20%), Query Frame = 2 
Query:  134 KPLLELYVKTSS-CEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSK--LLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNIT-VDQLKKLNSMGNKRLM 871
            KP++EL++K S  C++D G CPI Q WFM+ Y L ++ +++L VT VN D P  +Y+ L +GR LPV ++I G    D +   +      + +E+ +L+  WK     L + S    EAE +F DLY++  + L T N     + L+++D +      ++L+ D ++  DC+LMPKL H+++     ++ DV  +L++++ Y + MY  EAF  SCP+DR++   Y D L    V Q  + + M + R++
Sbjct:   15 KPVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKG---ADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRYLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYYDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A504YA87 (Chloride intracellular channel exc-4 OS=Fasciola gigantica OX=46835 GN=FGIG_11677 PE=4 SV=1)

HSP 1 Score: 154.836 bits (390), Expect = 2.326e-41
Identity = 98/258 (37.98%), Postives = 137/258 (53.10%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCED-DIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKI----ISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNEN--SIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKK---LNSMGNKRLMDI 877
            KPL+EL+V+ SS +  + G C   Q WFMILY LV+   IDL++TP+  D P  SY  L   R LP+  I    ISG E  D          I S +E+  L+       LN +     + +AE  F DL  +    +           L+K+D++    N +FL+G  +S  DC LMPKLQH+R+ C   K  D+ E+  H+  Y+ +MY  EAFI+SCPSDR+IILHY +      D LKK   L  +G++ L D+
Sbjct:    6 KPLVELFVQASSTDKTEKGPCLTSQQWFMILYSLVERGLIDLRLTPMTHDCPPKSYTDLNAARYLPIAWIQSGTISGYERSD--------KAIASWDEMELLMNELGYPYLNPSLSETDVRQAEQVFEDLMSNLMQLIRLGKAKPLLNTLEKIDNFLASKNQRFLLGPELSYPDCLLMPKLQHVRVLCQTHKNSDIPEHFKHLCRYVGEMYRSEAFIRSCPSDRDIILHYMEK-----DALKKNFRLRLLGSESLNDV 250
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8G5H8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig009590g1 PE=4 SV=1)

HSP 1 Score: 152.91 bits (385), Expect = 1.218e-40
Identity = 85/239 (35.56%), Postives = 133/239 (55.65%), Query Frame = 2 
Query:  134 KPLLELYVKTSS-CEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGN-ELYELLKYWK--SKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFT-ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDV-FENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQ 832
            KP++EL++K S    +D G CPI Q WFM+ Y L ++  ++L VT VN D P  +Y+ L +G++LPV ++I G++L     E    N +   N E+ +L+  W+  +  L + S +   AE  F DLY    IFL +    K    L K++ Y     + ++L+G  +S  DC+LMPKL H RI     +  D+   +L  ++ Y+ +MY   AF+ SCP+DR+I+ HY D L+    Q
Sbjct:    4 KPVIELFIKVSPIGREDKGPCPISQQWFMVFYLLAEKKIVNLFVTTVNPDLPPEAYQALDVGKRLPVARVIKGRDLKGTDLE----NLVCDTNDEIEQLMDVWRCPALALPKESPEEAAAERCFADLYTGLNIFLKSGVDTKLRTSLFKINSYLAERPDVQYLIGQELSYADCQLMPKLHHARIAAKAYRNYDIPSPDLRFLQQYMERMYKTAAFVDSCPADRDIVQHYFDKLDPPSRQ 238
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic4 (chloride intracellular channel 4 [Source:NCBI gene;Acc:103041029])

HSP 1 Score: 76.2554 bits (186), Expect = 1.185e-15
Identity = 64/259 (24.71%), Postives = 112/259 (43.24%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL-------KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTN--------------NFNKFHYYLKK----------LDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            +P++EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +   +G+   D              N++ E L       KY  SKL      +  E+  + +D++  F  ++  +                 K   YL+           +DD   +   KFL GD +++ DC L+PKL  +++     +  ++ +++  I  Y+N  Y+ E F  +CPSD+ I + Y D
Sbjct:   14 EPVIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTHPPFI-TFNGEVKTDV-------------NKIEEFLEDVLSPPKY--SKL----GARHPESNTAGMDIFAKFSAYIKNSRPDTNEGLERGLLKTLQKLDEYLRSPLPDEIDHNSMDDDIKVSARKFLDGDDMTLADCNLLPKLHIVKVVAKKYRGFEIPKDMLGIWGYLNNAYTREEFTNTCPSDKEIEIAYAD 245
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic3 (chloride intracellular channel protein 4-like [Source:NCBI gene;Acc:103028884])

HSP 1 Score: 72.7886 bits (177), Expect = 1.433e-14
Identity = 62/244 (25.41%), Postives = 107/244 (43.85%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK-YWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFN-------KFHYYLKKLDDYF--------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHY 802
            P +EL++K S   + +G+CP CQ  FMIL+ L   NF    +T V++       K L  G + P + I +G+   D              N++ E L+         +   +  E+  +  D++  F  ++   N         KF   L KLD Y               +  + ++L GD +++ DC L+PKL  +++ C   ++  + E L  +  Y+ K Y  + F  +CP+D  I+L Y
Sbjct:    5 PKVELFIKASDDGEGVGNCPFCQRLFMILW-LKGVNFT---LTTVDMKRAPEVLKDLAPGSQPPFL-IYNGEVRTDT-------------NKIEEFLEETLAPPQYPKLCCRYKESNRAGDDIFHKFSAYIKNPNPGLNDMLEKKFLRSLMKLDQYLLTPLPCELDKNPDASQSSRQYLDGDSLTLADCNLLPKLHIVKVVCRKYRDFVIPEALVGLTRYLEKAYQQDEFRYTCPNDAEILLAY 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: ENSAMXT00000047642.1 (chloride intracellular channel protein 4-like [Source:NCBI gene;Acc:103024513])

HSP 1 Score: 72.4034 bits (176), Expect = 2.089e-14
Identity = 62/251 (24.70%), Postives = 106/251 (42.23%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNEN----SIKIHEAEFSFLDLYRDFKIFL------TTNNFNK-FHYYLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P +EL+VK  S  + IG+CP  Q  FMIL+       +   VT V++       + L  G   P +   +G+ L+D              N++ E L+    +L+       S+K  E+  + +D++  F  ++        +   K     LK+LD+Y                       FL G  +++ DC L+PKL  I+I     +  ++  ++  +  Y+N  Y  E FI +CP++R I   Y D
Sbjct:   14 PTIELFVKAGSDGESIGNCPFSQRLFMILWL----KGVIFNVTTVDLKRKPADLQDLAPGTNPPFM-TFNGEVLVDV-------------NKIEEFLE---ERLVPPRYPKLSVKHPESNTAGIDVFAKFSAYIKNPRKEANDGLEKVLLKSLKRLDEYLQSPLPEEIDENSTDDPGPSTRSFLDGQDLTLADCNLLPKLHIIKIVAKKYRGFEIPADMTGVWRYLNSAYQREEFINTCPAEREIEFAYLD 243
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic2 (chloride intracellular channel 2 [Source:NCBI gene;Acc:103028266])

HSP 1 Score: 67.0106 bits (162), Expect = 1.486e-12
Identity = 58/252 (23.02%), Postives = 105/252 (41.67%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL---KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFH-----YYLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLN 817
            +P +EL++K     +++G+CP CQ+ FM+L+       +   VT V++       K L  G   P + + +G         +++ +FI     L   L   +Y     LN+ S  +        D++  F  F+  +  N           K+LD Y                 T+ + K+L G+ +++ DC L+PKL  I++        D+  +   +  Y+    + E FIQ+CP++  I   Y    N
Sbjct:   10 EPTIELFIKAGHDGENVGNCPFCQSLFMVLWL----KGVKFTVTTVDMRKKPEELKDLAPGTNPPFL-LYNG---------VLKTDFIKIEEFLETTLAPPRYPHLSPLNKESFDVGA------DIFAKFSAFIKNSPNNSIQEQALLREFKRLDIYLSTPLPEEIDHNSRENITVSSRKYLDGNRLTLADCNLLPKLHVIKVAAKKYCNFDIPAHFSAVHRYLQNANAREEFIQTCPANIEIEKAYLSVAN 241
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic5a (chloride intracellular channel 5 [Source:NCBI gene;Acc:103041670])

HSP 1 Score: 66.2402 bits (160), Expect = 3.158e-12
Identity = 59/244 (24.18%), Postives = 106/244 (43.44%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLY-RDFKIFLTTNNFNKFHYYLKKLDDYFTI---------------CNS-KFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P +EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +   +G    + Q+++ +        E+    KY K    N  S       FS    Y ++ +     +  N     L+KLD+Y                  C++ K+L  + +++ DC L+PKL  +++     +  D+      ++ Y+   Y+ + FI +C +D+ I L Y+D
Sbjct:    7 PDIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHN-------LAPGTHPPFL-TFNG----EVQTDVNKIEEYLE--EMLAPPKYPKLSAKNRESNTAGNDIFSKFSAYVKNTQPEANASLENGLLKALRKLDNYLNTPLPEEIDADSMEEEKCSTRKYLDSNELTLADCNLLPKLHVVKVVSKKYRNFDIPSEYTGVRRYLQNAYARDEFINTCAADKEIELAYQD 236
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 85.5001 bits (210), Expect = 1.226e-19
Identity = 68/245 (27.76%), Postives = 112/245 (45.71%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL---KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHY------YLKKLDDYFT-----------ICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            +P +EL+VK  S  + IG+CP+CQ  FM+L+       +   VT V++       + L  G + P +            +  VR +FI     L E L   +Y    +  ++S K     FS    Y   K    T+N +  +        LK+LDDY             +   KFL G+ +++ DC+L+PKL  +++ C   +  D+ E L  I  Y+   Y+ + F+++CP+DR I L Y +
Sbjct:   14 EPSIELFVKAGSDGETIGNCPLCQRIFMVLWL----KGVTFNVTTVDMTKKPAILRSLAPGSQPPFLTF----------NGDVRTDFIKIEEFLEETLCPPRYPSLGVKYQSSYKAGADVFSRFSAY--IKNSSATDNGSDNYLMKNLLKALKRLDDYLKEPLPYEENSSDVTERKFLDGNQLTLADCDLLPKLHIVKVVCKRYRGFDIPEQLMGIWHYLKNAYAQDEFMRTCPADREIELAYAE 242
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Match: clic6 (chloride intracellular channel 6 [Source:ZFIN;Acc:ZDB-GENE-121214-172])

HSP 1 Score: 72.0182 bits (175), Expect = 5.214e-15
Identity = 62/249 (24.90%), Postives = 104/249 (41.77%), Query Frame = 2 
Query:  143 LELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKI----HEAEFSFLDLYRDFKIFL------TTNNFNK-FHYYLKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            LEL V+  S  + IG+CP  Q  FMIL+       +   VT V++       + L  G   P +   +G+   D              N++ E L+    +L   N +++     E+  +  D++  F  ++        +N  K      KKLDDY                  I   KFL GD +++ DC L+PKL  ++I     ++ ++   +  +  Y+   Y+ + F  +CP+DR I L Y D
Sbjct:    8 LELRVRAGSDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDIKRKPPELQNLAPGTHPPFL-TFNGEVKTDV-------------NKIEEFLE---EQLSPPNYVRLAARHRESNLAGNDVFAKFSAYIKNAKKEANDNLEKALLKAFKKLDDYLLSPLPEEIDDCSMGDDGISPRKFLDGDELTLADCNLLPKLHIVKIVAKKYRDFEIPAEMTGVWKYLRGAYARDEFTNTCPADREIELAYAD 235
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: clic4 (chloride intracellular channel 4 [Source:NCBI gene;Acc:101159958])

HSP 1 Score: 79.337 bits (194), Expect = 8.081e-17
Identity = 65/255 (25.49%), Postives = 112/255 (43.92%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIH----EAEFSFLDLYRDFKIFLTTNNFNKFHYY-------LKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            +P++EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +   +G+   D              N++ E L+     L     IK+     E+  + +D++  F  F+  +  +            L+KLD+Y                  +   KFL GD +++ DC L+PKL  +++     +  D+ + +  I  Y+N  Y+ E FI +CPSD+ I + Y D
Sbjct:   15 EPIIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTHPPFI-TFNGEVKTDV-------------NKIEEFLE---DVLCPPKFIKLGARHPESNTAGMDIFAKFSAFIKNSKPDANEALERGLLKTLQKLDEYLRTPLPDEIDHNSIEDVKVSGRKFLDGDEMTLADCNLLPKLHIVKVVARKYRGFDIPKEMTAIWKYLNNAYTREEFINTCPSDKEIEIAYAD 245
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: ENSORLT00000037696.1 (chloride intracellular channel protein 4 [Source:NCBI gene;Acc:101172747])

HSP 1 Score: 71.2478 bits (173), Expect = 5.504e-14
Identity = 62/249 (24.90%), Postives = 107/249 (42.97%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKI----HEAEFSFLDLYRDFKIFLTTNNFN-------KFHYYLKKLDDYFTI--------------CNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYR 805
            +P +EL+VK S   + +G+CP CQ  FMIL+ L    F+   +T V++       K L  G + P + I +G+   D              N++ E L+    KL      K+     E+  +  D++R F  ++   N         +F   L KL+ Y                  +  +L G+  ++ DC L+PKL  +++ C   +  D+   L  +  Y++  Y  + F  +CP D  I+L Y+
Sbjct:    4 EPNIELFVKASLDAESVGNCPFCQRLFMILW-LKRAEFV---LTTVDMKRAPEVLKALAPGSQPPFL-IFNGEVKTDT-------------NKIEEFLE---EKLAPPRYPKLCCTYKESNLAGEDIFRKFSAYIKNPNPGLNIMLEKQFLSTLVKLNMYLETPLPHELERNPDANESSRLYLDGNAFTLADCNLLPKLNIVKVVCKKYRNFDIPTELKGLTRYLDNAYKQDEFRHTCPQDEEILLAYK 231
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: ENSORLT00000013178.2 (chloride intracellular channel protein 4 [Source:NCBI gene;Acc:101172747])

HSP 1 Score: 71.2478 bits (173), Expect = 6.252e-14
Identity = 62/249 (24.90%), Postives = 107/249 (42.97%), Query Frame = 2 
Query:  134 KPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKI----HEAEFSFLDLYRDFKIFLTTNNFN-------KFHYYLKKLDDYFTI--------------CNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYR 805
            +P +EL+VK S   + +G+CP CQ  FMIL+ L    F+   +T V++       K L  G + P + I +G+   D              N++ E L+    KL      K+     E+  +  D++R F  ++   N         +F   L KL+ Y                  +  +L G+  ++ DC L+PKL  +++ C   +  D+   L  +  Y++  Y  + F  +CP D  I+L Y+
Sbjct:   19 EPNIELFVKASLDAESVGNCPFCQRLFMILW-LKRAEFV---LTTVDMKRAPEVLKALAPGSQPPFL-IFNGEVKTDT-------------NKIEEFLE---EKLAPPRYPKLCCTYKESNLAGEDIFRKFSAYIKNPNPGLNIMLEKQFLSTLVKLNMYLETPLPHELERNPDANESSRLYLDGNAFTLADCNLLPKLNIVKVVCKKYRNFDIPTELKGLTRYLDNAYKQDEFRHTCPQDEEILLAYK 246
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BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: ENSORLT00000037869.1 (chloride intracellular channel protein 5 [Source:NCBI gene;Acc:101168438])

HSP 1 Score: 69.707 bits (169), Expect = 1.714e-13
Identity = 60/249 (24.10%), Postives = 105/249 (42.17%), Query Frame = 2 
Query:  137 PLLELYVKTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNK-------FHYYLKKLDDYF---------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            P +EL+VK  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P    ++ KE +      + +       ++    KY K    N +S        + +D++  F  ++     +K        +  L KLD+Y                     K+L GD +++ DC L+PKL  +++     +  ++  +L  +  Y+   Y  + FI +CP+D  I L YRD
Sbjct:   12 PDIELFVKAGSDGEAIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHN-------LAPGTNPP---FLTFKEEVLTDVNKIEEYL----EQMLAPPKYPKLAPKNRDS------NTAGIDIFAKFSAYVKNTRPDKNRALEQALNKALMKLDEYLMSPVPEEVQKGRHHEEPSTRKYLDGDELTLADCNLLPKLHVLKVVAKKYRNYEIPSDLKGVWRYLGNAYERDEFINTCPADEEIELAYRD 240
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BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: clic4 (chloride intracellular channel 4 [Source:NCBI gene;Acc:101159958])

HSP 1 Score: 69.3218 bits (168), Expect = 3.506e-13
Identity = 59/245 (24.08%), Postives = 104/245 (42.45%), Query Frame = 2 
Query:  158 KTSSCEDDIGSCPICQTWFMILY---QLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK--YWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYY-------LKKLDDYF----------------TICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRD 808
            K  S  + IG+CP  Q  FMIL+    + +   +DL+  P ++ N       L  G   P +   +G+   D              N++ E L+      K +   + +  E+  + +D++  F  F+  +  +            L+KLD+Y                  +   KFL GD +++ DC L+PKL  +++     +  D+ + +  I  Y+N  Y+ E FI +CPSD+ I + Y D
Sbjct:   29 KAGSDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQN-------LAPGTHPPFI-TFNGEVKTDV-------------NKIEEFLEDVLCPPKFIKLGA-RHPESNTAGMDIFAKFSAFIKNSKPDANEALERGLLKTLQKLDEYLRTPLPDEIDHNSIEDVKVSGRKFLDGDEMTLADCNLLPKLHIVKVVARKYRGFDIPKEMTAIWKYLNNAYTREEFINTCPSDKEIEIAYAD 251
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BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000007126.1 (SMESG000007126.1)

HSP 1 Score: 510.76 bits (1314), Expect = 0.000e+0
Identity = 251/252 (99.60%), Postives = 251/252 (99.60%), Query Frame = 2 
Query:  128 MLKPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNSMGNKRLMDIEH 883
            MLKPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLK WKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNSMGNKRLMDIEH
Sbjct:    1 MLKPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELLKSWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNSMGNKRLMDIEH 252
[Close]
BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000054543.1 (SMESG000054543.1)

HSP 1 Score: 155.606 bits (392), Expect = 1.929e-45
Identity = 85/230 (36.96%), Postives = 128/230 (55.65%), Query Frame = 2 
Query:  137 PLLELYVKTSSCED-DIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKIISGKELIDCQ--SEIVRKNFIFSGNELYELLKYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLN 817
            P++EL+VK+S  +  D G CPI Q WFM  Y LV+   I+L+VTPV++ NP   Y +L +GR LPV  +I GK  +  +  ++++  N     +E+  L+  +K   L   +      E    DL+R+F  +L TNN       L  L+D+    ++K+L GD +S  DC +MPKLQH+RI C   K   +      +  Y+  MY  +AF+ SCP DR+II+HY +  N
Sbjct:    9 PIIELFVKSSPVDPADKGPCPISQKWFMAYYTLVENQLINLRVTPVDIKNPPQEYLKLNVGRHLPVALVIEGKHPMTGEDMADLIADN----DDEIENLMDKFKCPGLELGATAFKVTE----DLFRNFNSYLQTNNSTNMLANLASLNDFIENRSNKYLQGDQVSFVDCVVMPKLQHLRIACAEFKNFQIPTEFKGLWKYLETMYETKAFMISCPCDRDIIIHYSEKTN 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000070758.1 (SMESG000070758.1)

HSP 1 Score: 134.806 bits (338), Expect = 1.634e-37
Identity = 82/235 (34.89%), Postives = 128/235 (54.47%), Query Frame = 2 
Query:  137 PLLELYVKTSSCE-DDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKI-----ISGKELIDCQSEIVRKNFIFSGNELYELLKYWKSKLLNEN--SIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLN 817
            P++EL+VK S  + +D GSCPI QTWFM  Y LV+   IDL+VTPVN++  C SY QL + R+LPV K+      SGK+L +  +E        + ++L +L+  +    L       ++ +AE    D+ +   I L T N       L ++D +    ++K L+ D ++  DC LMP+LQH+R+    L   D+  NL H+  YI  MY  + F  +C  DR+II  + + ++
Sbjct:    3 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAE--------TTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVS 229
The following BLAST results are available for this feature:
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CLIC13.041e-1525.20chloride intracellular channel 1 [Source:HGNC Symb... [more]
CLIC13.041e-1525.20chloride intracellular channel 1 [Source:HGNC Symb... [more]
CLIC13.041e-1525.20chloride intracellular channel 1 [Source:HGNC Symb... [more]
CLIC13.041e-1525.20chloride intracellular channel 1 [Source:HGNC Symb... [more]
CLIC13.041e-1525.20chloride intracellular channel 1 [Source:HGNC Symb... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
exc-49.717e-3029.77Chloride intracellular channel exc-4 [Source:UniP... [more]
exl-13.255e-1925.82Chloride intracellular channel exl-1 [Source:UniP... [more]
exl-13.255e-1925.82Chloride intracellular channel exl-1 [Source:UniP... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Clic3.714e-2429.26gene:FBgn0030529 transcript:FBtr0346089[more]
Clic3.714e-2429.26gene:FBgn0030529 transcript:FBtr0073835[more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic26.695e-1525.00chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic26.695e-1525.00chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic26.695e-1525.00chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
pnpla7a4.061e-1425.21patatin-like phospholipase domain containing 7a [S... [more]
clic34.061e-1425.21chloride intracellular channel 3 [Source:ZFIN;Acc:... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic42.025e-1425.30chloride intracellular channel 5 [Source:NCBI gene... [more]
clic12.876e-1223.53chloride intracellular channel 1 [Source:NCBI gene... [more]
st3gal52.032e-1123.90ST3 beta-galactoside alpha-2,3-sialyltransferase 5... [more]
clic44.734e-1123.97chloride intracellular channel 5 [Source:NCBI gene... [more]
CLIC62.099e-1023.97chloride intracellular channel 6 [Source:NCBI gene... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Clic14.511e-1626.00chloride intracellular channel 1 [Source:MGI Symbo... [more]
Clic48.938e-1524.03chloride intracellular channel 4 (mitochondrial) [... [more]
Clic55.210e-1224.02chloride intracellular channel 5 [Source:MGI Symbo... [more]
Clic64.129e-1125.79chloride intracellular channel 6 [Source:MGI Symbo... [more]
Clic59.352e-1024.30chloride intracellular channel 5 [Source:MGI Symbo... [more]
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BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8WQA4|EXC4_CAEEL1.236e-2829.77Chloride intracellular channel exc-4 OS=Caenorhabd... [more]
sp|O45405|EXL1_CAEEL4.140e-1825.82Chloride intracellular channel exl-1 OS=Caenorhabd... [more]
sp|Q9Z1Q5|CLIC1_MOUSE3.155e-1526.00Chloride intracellular channel protein 1 OS=Mus mu... [more]
sp|Q6MG61|CLIC1_RAT4.817e-1526.00Chloride intracellular channel protein 1 OS=Rattus... [more]
sp|O00299|CLIC1_HUMAN1.460e-1425.20Chloride intracellular channel protein 1 OS=Homo s... [more]
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BLAST of Chloride intracellular channel 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8GES94.283e-4434.00Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GET51.038e-4334.00Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8G1692.859e-4333.60Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A504YA872.326e-4137.98Chloride intracellular channel exc-4 OS=Fasciola g... [more]
A0A1I8G5H81.218e-4035.56Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic41.185e-1524.71chloride intracellular channel 4 [Source:NCBI gene... [more]
clic31.433e-1425.41chloride intracellular channel protein 4-like [Sou... [more]
ENSAMXT00000047642.12.089e-1424.70chloride intracellular channel protein 4-like [Sou... [more]
clic21.486e-1223.02chloride intracellular channel 2 [Source:NCBI gene... [more]
clic5a3.158e-1224.18chloride intracellular channel 5 [Source:NCBI gene... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
clic21.226e-1927.76chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic65.214e-1524.90chloride intracellular channel 6 [Source:ZFIN;Acc:... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Chloride intracellular channel 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic48.081e-1725.49chloride intracellular channel 4 [Source:NCBI gene... [more]
ENSORLT00000037696.15.504e-1424.90chloride intracellular channel protein 4 [Source:N... [more]
ENSORLT00000013178.26.252e-1424.90chloride intracellular channel protein 4 [Source:N... [more]
ENSORLT00000037869.11.714e-1324.10chloride intracellular channel protein 5 [Source:N... [more]
clic43.506e-1324.08chloride intracellular channel 4 [Source:NCBI gene... [more]
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BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000007126.10.000e+099.60SMESG000007126.1[more]
SMESG000054543.11.929e-4536.96SMESG000054543.1[more]
SMESG000070758.11.634e-3734.89SMESG000070758.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013924 ID=SMED30013924|Name=Chloride intracellular channel 4|organism=Schmidtea mediterranea sexual|type=transcript|length=988bp
AAATTTTAAAGTTTTATTTTCTAAGAAATCGTTAGTTTTAGAAATTTTAT
GTGTCATATTTTTCATCATTAGATATTACATAAATTATATTCTTGTTGTT
AAAATTTTATTTATTAGATTTTAAAGAATGTTGAAACCCCTTTTAGAATT
ATATGTTAAAACTTCATCTTGTGAAGATGATATTGGATCTTGTCCGATTT
GTCAGACCTGGTTTATGATACTCTATCAATTAGTGGACGAAAATTTTATT
GATTTGCAAGTAACACCAGTAAATGTTGACAATCCTTGCAATTCTTACAA
ACAATTAGGTATGGGCAGAAAGTTACCCGTCGTTAAAATTATTTCTGGAA
AAGAATTAATTGATTGTCAATCTGAGATAGTGCGAAAAAATTTTATATTT
AGTGGAAATGAATTATATGAATTGTTGAAATATTGGAAATCTAAATTACT
TAATGAGAACTCAATAAAAATACATGAAGCTGAATTCTCTTTTCTAGATT
TATATAGAGATTTTAAAATTTTTTTAACAACAAATAACTTTAATAAGTTT
CATTATTATTTAAAGAAATTAGACGATTATTTTACTATTTGTAATAGCAA
ATTTTTAGTTGGAGATTTTATATCAATTTGTGATTGTGAATTAATGCCAA
AACTGCAGCATATAAGAATTACTTGTATTTTATTAAAGGAAATTGATGTT
TTTGAAAATTTAGATCATATCAAAACATATATAAATAAGATGTATTCAGT
TGAAGCATTTATTCAGTCTTGTCCAAGTGACAGAAATATTATTTTACATT
ATCGTGATACATTGAATATAACTGTAGACCAATTGAAGAAATTAAATTCA
ATGGGAAATAAGAGATTGATGGACATAGAGCATTAGATATTATACTCATT
ATTTGAAATTATTGTTTTAATCTCTGATTAAATTTTTGAGTTTAGATAAA
TTTATATTGCTATGGTAACCTATTTGATTGATTTTCTG
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protein sequence of SMED30013924-orf-1

>SMED30013924-orf-1 ID=SMED30013924-orf-1|Name=SMED30013924-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=253bp
MLKPLLELYVKTSSCEDDIGSCPICQTWFMILYQLVDENFIDLQVTPVNV
DNPCNSYKQLGMGRKLPVVKIISGKELIDCQSEIVRKNFIFSGNELYELL
KYWKSKLLNENSIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDD
YFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKT
YINKMYSVEAFIQSCPSDRNIILHYRDTLNITVDQLKKLNSMGNKRLMDI
EH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036249Thioredoxin-like_sf
IPR036282Glutathione-S-Trfase_C_sf
IPR010987Glutathione-S-Trfase_C-like
IPR012336Thioredoxin-like_fold
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.20.1050.10coord: 112..251
e-value: 1.1E-29
score: 105.4
NoneNo IPR availablePANTHERPTHR43920:SF5CHLORIDE INTRACELLULAR CHANNEL, ISOFORM Acoord: 3..239
NoneNo IPR availablePANTHERPTHR43920FAMILY NOT NAMEDcoord: 3..239
IPR036249Thioredoxin-like superfamilyGENE3DG3DSA:3.40.30.10coord: 1..89
e-value: 6.7E-18
score: 67.0
IPR010987Glutathione S-transferase, C-terminal-likePROSITEPS50405GST_CTERcoord: 97..228
score: 9.828
IPR036282Glutathione S-transferase, C-terminal domain superfamilySUPERFAMILYSSF47616GST C-terminal domain-likecoord: 141..228