U3 small nucleolar RNA-associated protein 18

Overview


Name	U3 small nucleolar RNA-associated protein 18
Smed ID	SMED30013876
Length (bp)	1361

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of U3 small nucleolar RNA-associated protein 18 (SMED30013876) t-SNE clustered cells

Violin plots show distribution of expression levels for U3 small nucleolar RNA-associated protein 18 (SMED30013876) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of U3 small nucleolar RNA-associated protein 18 (SMED30013876) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013876

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30013876	h1SMcG0000016	SmedASXL_010258	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30013876	h1SMcG0000016	SmedASXL_010258	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30013876	h1SMcG0000016	dd_Smed_v4_3855_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
Match: UTP18 (UTP18 small subunit processome component [Source:HGNC Symbol;Acc:HGNC:24274])

HSP 1 Score: 133.265 bits (334), Expect = 3.888e-33
Identity = 94/347 (27.09%), Postives = 167/347 (48.13%), Query Frame = 3

Query:  324 IQKFG-VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLNLATGNIKNLKIDTERI-RRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            +Q+ G  ++T   L  G L+   C   N + P+   IS    H     ++ A  +  + LF++DG+ N  + +  YL++FPI       +G+ V+  S  S     Y +L      +  ++   E+I R  E SP G F+++      L +++  T  +I  + ++  + +  FS   K +Y     G++ V++   ++      ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LA+     +       RL+++ S TV+ NFP   +   +   +  FSP   Y A+G   GK  ++ L+HY  F
Sbjct:  218 LQRTGNFISTSTSLPRGILKMKNCQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKI-QSIYLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRK---CLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIA----SEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHHYSDF 556

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
Match: UTP18 (UTP18 small subunit processome component [Source:HGNC Symbol;Acc:HGNC:24274])

HSP 1 Score: 58.9214 bits (141), Expect = 3.848e-10
Identity = 32/100 (32.00%), Postives = 55/100 (55.00%), Query Frame = 3

Query:  840 KYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVG 1136
            K +Y     G++ V++   ++      ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LA+ 
Sbjct:    4 KKVYASSGDGEVYVWDVNSRK---CLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIA 100

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
Match: UTP18 (UTP18 small subunit processome component [Source:HGNC Symbol;Acc:HGNC:24274])

HSP 1 Score: 56.9954 bits (136), Expect = 1.393e-9
Identity = 28/73 (38.36%), Postives = 44/73 (60.27%), Query Frame = 3

Query:  921 KWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVG 1136
            ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LA+ 
Sbjct:   10 RFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIA 82

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
Match: UTP18 (UTP18 small subunit processome component [Source:HGNC Symbol;Acc:HGNC:24274])

HSP 1 Score: 52.7582 bits (125), Expect = 1.510e-7
Identity = 41/164 (25.00%), Postives = 77/164 (46.95%), Query Frame = 3

Query:  546 YLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLNLATGNIKNLKIDTERI-RRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACG-SLGLLNIY 1019
            YL++FPI       +G+ V+  S  S     Y +L      +  ++   E+I R  E SP G F+++      L +++  T  +I  + ++  + +  FS   K +Y     G++ V++   ++      ++ D   +  + IA S + Q+VACG  LG L +Y
Sbjct:    2 YLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRK---CLNRFVDEGSLYGLSIATSRNGQYVACGLKLGKLLVY 162

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Celegans
Match: B0280.9 (U3 small nucleolar RNA-associated protein 18 homolog [Source:UniProtKB/Swiss-Prot;Acc:P42000])

HSP 1 Score: 117.857 bits (294), Expect = 7.808e-29
Identity = 92/329 (27.96%), Postives = 161/329 (48.94%), Query Frame = 3

Query:  396 DGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDR---PFYLDKFPINGGQLLPDGKNVVFFSKRSYYKV-LNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAF--SHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP---GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            D N  H  ++ I+    H+ +  +I A   G + LFK+  E     DR        KFPI+  ++   G +V+  S R  Y +  N+ T  +  LK    +  + IR    S    F+ +A  N+ ++V+   +   I  + + +    + F  SHS + +++  E G+I +       G    +  F  DG ++   +AIS    + A GS  G++N+YS NDC N+  P+P+ ++    + V+ + FN  ++L+A+     +N      RL+++AS T + NFP   G V  AR     FSPNG Y+AVG  +G++ +F ++H+  +
Sbjct:  111 DFNIGHRYTRGITVVKFHKTRPVLIVADQGGNVQLFKVSREVKK--DRFLQSANFSKFPIDSLEIADKGHSVICSSSRKEYLMQYNMETREVTQLKPPNTVPKQGIRLFAISHDSQFLAIAGHNSHIYVLHATSMEHITTISLPANASEIKFFPSHS-REIWIICETGQIVIANIGLP-GTKSSQHTFTDDGAVHGTTLAISQHGDYFATGSDTGIVNVYSGNDCRNSTNPRPLFNVSNLVTAVSSIAFNSDAQLMAI----CSNVKDNHLRLVHVASQTTFKNFPERNGKVTHAR--CVEFSPNGGYMAVGNDDGRLHVFEIHHFTDY 429

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Fly
Match: wcd (gene:FBgn0262560 transcript:FBtr0087170)

HSP 1 Score: 119.013 bits (297), Expect = 8.825e-29
Identity = 93/328 (28.35%), Postives = 145/328 (44.21%), Query Frame = 3

Query:  375 LEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNLKID--TERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGS---VGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            L F R  D NR   +    +    H      + A   G   ++ +DG+ N  +       KFP+   ++ P G    F S + +Y   +L       LK+    E + R E SP G FIV A +   + +++  T  ++H       +K   +S   K + V      +SV   ++          F  DG I+   I +S + + +A GS  G++NIY     + ++ P+P K      + +  LQFNHSSELLA+  S   N     F+L +  S TVY NFP     VG    TS +FSP+  +LA      +V LF L ++K +
Sbjct:  190 LNFKRVKDLNRATYAEGNATSIQFHPTSTAALVAGMNGLATIYAVDGQKNERLHN-MRFKKFPLACSRIAPCGTRAFFGSVKPFYYSYDLLEAKESKLKLPGAMEFMHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFKQEGKVKGFTWSSDSKRILVCGSTSNVSVLNLRQN----LIEHIFMDDGCIHGESIQLSPNQRLLATGSQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPN----AFKLAHFPSATVYSNFPAQNEKVGFV--TSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY 506

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Match: utp18 (UTP18 small subunit processome component [Source:NCBI gene;Acc:549389])

HSP 1 Score: 139.428 bits (350), Expect = 1.463e-35
Identity = 89/341 (26.10%), Postives = 171/341 (50.15%), Query Frame = 3

Query:  339 VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            +L+   +L  G ++  +CI+ N +  S   ++    H     ++TA  + ++ LF++DG+ N  + +  +L+KFPI   Q   DG+ V+    RS  + + ++  GNI  +     ++   I++ E SP+G F++L      L ++S  T  +I  + ++       FS     ++   + G + V++ + ++      K+ D   I    IA+S D ++++CGS  G++NIY+  DC     P+P+K+I    +  + + FN  +E++AV     +N T    +L+++ S +V+ NFPG    +   P +  FSP   Y ++    G+  L+ L HY  F
Sbjct:  190 LLSQSSYLSKGVIQIRKCINANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKI-QSIHLEKFPIYKAQFSADGEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMKTKELIGSMKMNGKSMKAVFSPDSSKVFSNSDDGFVYVWDVRSRQ---CLNKFTDEGSICGTSIALSRDGRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVA----SNKTDDAVKLVHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEALLYRLKHYSDF 522

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Match: utp18 (UTP18 small subunit processome component [Source:NCBI gene;Acc:549389])

HSP 1 Score: 131.724 bits (330), Expect = 9.827e-34
Identity = 87/343 (25.36%), Postives = 172/343 (50.15%), Query Frame = 3

Query:  339 VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNGKVTLF--ALNHYKAF 1337
            +L+   +L  G ++  +CI+ N +  S   ++    H     ++TA  + ++ LF++DG+ N  + +  +L+KFPI   Q   DG+ V+    RS  + + ++  GNI  +     ++   I++ E SP+G F++L      L ++S  T  +I  + ++       FS     ++   + G + V++ + ++      K+ D   I    IA+S D ++++CGS  G++NIY+  DC     P+P+K+I    +  + + FN  +E++AV     +N T    +L+++ S +V+ NFPG    +   P +  FSP   Y ++    G+  L+   + H+ +F
Sbjct:   38 LLSQSSYLSKGVIQIRKCINANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKI-QSIHLEKFPIYKAQFSADGEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMKTKELIGSMKMNGKSMKAVFSPDSSKVFSNSDDGFVYVWDVRSRQ---CLNKFTDEGSICGTSIALSRDGRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVA----SNKTDDAVKLVHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEALLYRWVIFHFTSF 372

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Match: utp18 (UTP18 small subunit processome component [Source:NCBI gene;Acc:549389])

HSP 1 Score: 129.028 bits (323), Expect = 6.764e-32
Identity = 90/346 (26.01%), Postives = 173/346 (50.00%), Query Frame = 3

Query:  339 VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNG-KVT----LFALNHYKAF 1337
            +L+   +L  G ++  +CI+ N +  S   ++    H     ++TA  + ++ LF++DG+ N  + +  +L+KFPI   Q   DG+ V+    RS  + + ++  GNI  +     ++   I++ E SP+G F++L      L ++S  T  +I  + ++       FS     ++   + G + V++ + ++      K+ D   I    IA+S D ++++CGS  G++NIY+  DC     P+P+K+I    +  + + FN  +E++AV     +N T    +L+++ S +V+ NFPG    +   P +  FSP   Y ++    G K++    LF L + K F
Sbjct:  190 LLSQSSYLSKGVIQIRKCINANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKI-QSIHLEKFPIYKAQFSADGEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMKTKELIGSMKMNGKSMKAVFSPDSSKVFSNSDDGFVYVWDVRSRQ---CLNKFTDEGSICGTSIALSRDGRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVA----SNKTDDAVKLVHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEKISLNNCLFKLLYLKHF 527

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Match: utp18 (UTP18 small subunit processome component [Source:NCBI gene;Acc:549389])

HSP 1 Score: 124.02 bits (310), Expect = 8.425e-31
Identity = 83/320 (25.94%), Postives = 160/320 (50.00%), Query Frame = 3

Query:  378 EFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNGKVTLF 1313
            E  +CI+ N +  S   ++    H     ++TA  + ++ LF++DG+ N  + +  +L+KFPI   Q   DG+ V+    RS  + + ++  GNI  +     ++   I++ E SP+G F++L      L ++S  T  +I  + ++       FS     ++   + G + V++ + ++      K+ D   I    IA+S D ++++CGS  G++NIY+  DC     P+P+K+I    +  + + FN  +E++AV     +N T    +L+++ S +V+ NFPG    +   P +  FSP   Y ++    G+  L+
Sbjct:   62 EGKKCINANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKI-QSIHLEKFPIYKAQFSADGEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMKTKELIGSMKMNGKSMKAVFSPDSSKVFSNSDDGFVYVWDVRSRQ---CLNKFTDEGSICGTSIALSRDGRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVA----SNKTDDAVKLVHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEALLY 373

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Match: utp18 (UTP18 small subunit processome component [Source:NCBI gene;Acc:549389])

HSP 1 Score: 117.857 bits (294), Expect = 4.656e-28
Identity = 93/350 (26.57%), Postives = 171/350 (48.86%), Query Frame = 3

Query:  339 VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVST----ATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNG-KVT----LFALNHYKAF 1337
            +L+   +L  G ++  +CI+ N +  S   ++    H     ++TA  + ++ LF++DG+ N  + +  +L+KFPI   Q   DG+ V+    RS  + + ++  GNI  +     ++   I++ E SP+G F++L      L ++S     + F     L +SS   SL F     ++YV++   +  +             K+ D   I    IA+S D ++++CGS  G++NIY+  DC     P+P+K+I    +  + + FN  +E++AV     +N T    +L+++ S +V+ NFPG    +   P +  FSP   Y ++    G K++    LF L + K F
Sbjct:  190 LLSQSSYLSKGVIQIRKCINANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKI-QSIHLEKFPIYKAQFSADGEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMKKPKSNFYAFTVLFISS--HSL-FPTDDGFVYVWDVRSRQCL------------NKFTDEGSICGTSIALSRDGRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVA----SNKTDDAVKLVHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEKISLNNCLFKLLYLKHF 519

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Mouse
Match: Utp18 (UTP18 small subunit processome component [Source:MGI Symbol;Acc:MGI:1923402])

HSP 1 Score: 147.902 bits (372), Expect = 1.623e-38
Identity = 99/349 (28.37%), Postives = 174/349 (49.86%), Query Frame = 3

Query:  324 IQKFG-VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLN---LATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            +Q+ G  ++T   L  G L+   C   N + P++  IS    H     ++ +  +  + LF++DG+ N  + +  YL+KFPI       +G+ V+  S  S     Y +L    +    ++ LK  T  +++ E SP G F++++       ++S  T  +I  + ++  I +  FS   K +Y Y E+G++ V++   ++      ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LAV     +       RL+++ S TV+ NFP       +R  +  FSP G Y A+G   G+  ++ L+HY  F
Sbjct:  214 LQRTGNFISTSTSLPRGILKMKNCRPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDGKTNPKI-QSIYLEKFPIFKACFSANGEEVLATSMHSKVLYVYDMLAGKLIPVHQVRGLKEKT--VKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYTYSENGEVYVWDVNSRK---CMNRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSCLQQTNPKPIKAIMNLVTGVTSLAFNPTTEILAVA----SRKMKEAVRLVHLPSCTVFSNFPVFKKSTLSRVQTMDFSPRGGYFALGNEKGRALMYRLHHYSDF 552

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Match: sp|Q5SSI6|UTP18_MOUSE (U3 small nucleolar RNA-associated protein 18 homolog OS=Mus musculus OX=10090 GN=Utp18 PE=1 SV=1)

HSP 1 Score: 147.902 bits (372), Expect = 1.135e-37
Identity = 99/349 (28.37%), Postives = 174/349 (49.86%), Query Frame = 3

Query:  324 IQKFG-VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLN---LATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            +Q+ G  ++T   L  G L+   C   N + P++  IS    H     ++ +  +  + LF++DG+ N  + +  YL+KFPI       +G+ V+  S  S     Y +L    +    ++ LK  T  +++ E SP G F++++       ++S  T  +I  + ++  I +  FS   K +Y Y E+G++ V++   ++      ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LAV     +       RL+++ S TV+ NFP       +R  +  FSP G Y A+G   G+  ++ L+HY  F
Sbjct:  214 LQRTGNFISTSTSLPRGILKMKNCRPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDGKTNPKI-QSIYLEKFPIFKACFSANGEEVLATSMHSKVLYVYDMLAGKLIPVHQVRGLKEKT--VKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYTYSENGEVYVWDVNSRK---CMNRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSCLQQTNPKPIKAIMNLVTGVTSLAFNPTTEILAVA----SRKMKEAVRLVHLPSCTVFSNFPVFKKSTLSRVQTMDFSPRGGYFALGNEKGRALMYRLHHYSDF 552

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Match: sp|Q9Y5J1|UTP18_HUMAN (U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3)

HSP 1 Score: 133.265 bits (334), Expect = 1.867e-32
Identity = 94/347 (27.09%), Postives = 167/347 (48.13%), Query Frame = 3

Query:  324 IQKFG-VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLNLATGNIKNLKIDTERI-RRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            +Q+ G  ++T   L  G L+   C   N + P+   IS    H     ++ A  +  + LF++DG+ N  + +  YL++FPI       +G+ V+  S  S     Y +L      +  ++   E+I R  E SP G F+++      L +++  T  +I  + ++  + +  FS   K +Y     G++ V++   ++      ++ D   +  + IA S + Q+VACGS  G++NIY+ + C     PKPIK+I    + V  L FN ++E+LA+     +       RL+++ S TV+ NFP   +   +   +  FSP   Y A+G   GK  ++ L+HY  F
Sbjct:  218 LQRTGNFISTSTSLPRGILKMKNCQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKI-QSIYLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRK---CLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIA----SEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHHYSDF 556

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Match: sp|Q9FMU5|UTP18_ARATH (U3 small nucleolar RNA-associated protein 18 homolog OS=Arabidopsis thaliana OX=3702 GN=At5g14050 PE=1 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 3.140e-31
Identity = 89/330 (26.97%), Postives = 163/330 (49.39%), Query Frame = 3

Query:  360 LKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNLKI----DTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTAR-PTSFSFSPNGKYLAVGRFNGKVTLFALNHYK 1331
            L AG LE+ + +D N   PS+  I+    H+N   ++TA  +  L  F+IDG+ N  + +  +L+  PI     LP+G  V+   +R ++   +L       +      + + +   E S   + I        + +VST T  +I  L ++ +++SLAFS  GK+L      G++ V++ +  +      K  D        +  S +    A G+  G++NIY  ++    +  KPIK++    S+++ ++FNH +++LA+  +   N+     +L+++ SLTV+ N+P    T   P    FSP   ++A+G   GKV L+ L+HY+
Sbjct:  224 LCAGRLEYSKLVDANAADPSNGPINSVHFHQNAQLLLTAGLDRRLRFFQIDGKRNTKI-QSIFLEDCPIRKAAFLPNGSQVIVSGRRKFFYSFDLEKAKFDKIGPLVGREEKSLEYFEVSQDSNTIAFVGNEGYILLVSTKTKELIGTLKMNGSVRSLAFSEDGKHLLSSGGDGQVYVWDLRTMK---CLYKGVDEGSTCGTSLCSSLNGALFASGTDRGIVNIYKKSEFVGGKR-KPIKTVDNLTSKIDFMKFNHDAQILAIVSTMNKNSV----KLVHVPSLTVFSNWPPPNSTMHYPRCLDFSPGSGFMAMGNAAGKVLLYKLHHYQ 544

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Match: sp|Q9V7P1|UTP18_DROME (U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster OX=7227 GN=wcd PE=1 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 8.846e-28
Identity = 93/328 (28.35%), Postives = 145/328 (44.21%), Query Frame = 3

Query:  375 LEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNLKID--TERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGS---VGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            L F R  D NR   +    +    H      + A   G   ++ +DG+ N  +       KFP+   ++ P G    F S + +Y   +L       LK+    E + R E SP G FIV A +   + +++  T  ++H       +K   +S   K + V      +SV   ++          F  DG I+   I +S + + +A GS  G++NIY     + ++ P+P K      + +  LQFNHSSELLA+  S   N     F+L +  S TVY NFP     VG    TS +FSP+  +LA      +V LF L ++K +
Sbjct:  190 LNFKRVKDLNRATYAEGNATSIQFHPTSTAALVAGMNGLATIYAVDGQKNERLHN-MRFKKFPLACSRIAPCGTRAFFGSVKPFYYSYDLLEAKESKLKLPGAMEFMHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFKQEGKVKGFTWSSDSKRILVCGSTSNVSVLNLRQN----LIEHIFMDDGCIHGESIQLSPNQRLLATGSQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPN----AFKLAHFPSATVYSNFPAQNEKVGFV--TSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY 506

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Match: sp|P42000|UTP18_CAEEL (U3 small nucleolar RNA-associated protein 18 homolog OS=Caenorhabditis elegans OX=6239 GN=B0280.9 PE=3 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 9.932e-28
Identity = 92/329 (27.96%), Postives = 161/329 (48.94%), Query Frame = 3

Query:  396 DGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDR---PFYLDKFPINGGQLLPDGKNVVFFSKRSYYKV-LNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAF--SHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP---GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            D N  H  ++ I+    H+ +  +I A   G + LFK+  E     DR        KFPI+  ++   G +V+  S R  Y +  N+ T  +  LK    +  + IR    S    F+ +A  N+ ++V+   +   I  + + +    + F  SHS + +++  E G+I +       G    +  F  DG ++   +AIS    + A GS  G++N+YS NDC N+  P+P+ ++    + V+ + FN  ++L+A+     +N      RL+++AS T + NFP   G V  AR     FSPNG Y+AVG  +G++ +F ++H+  +
Sbjct:  111 DFNIGHRYTRGITVVKFHKTRPVLIVADQGGNVQLFKVSREVKK--DRFLQSANFSKFPIDSLEIADKGHSVICSSSRKEYLMQYNMETREVTQLKPPNTVPKQGIRLFAISHDSQFLAIAGHNSHIYVLHATSMEHITTISLPANASEIKFFPSHS-REIWIICETGQIVIANIGLP-GTKSSQHTFTDDGAVHGTTLAISQHGDYFATGSDTGIVNVYSGNDCRNSTNPRPLFNVSNLVTAVSSIAFNSDAQLMAI----CSNVKDNHLRLVHVASQTTFKNFPERNGKVTHAR--CVEFSPNGGYMAVGNDDGRLHVFEIHHFTDY 429

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Match: A0A4W5KCF4 (WD_REPEATS_REGION domain-containing protein OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 164.851 bits (416), Expect = 1.860e-42
Identity = 98/341 (28.74%), Postives = 175/341 (51.32%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + D L  G +   +C+  N D PS   ++    H +   ++TA  + ++ LF++DG+ N  + +  +L+KFP++  Q   DG+ VV  S R+  + + ++  G +  +     +  +R++  E SP G+ ++L   +  L V++  T  V+  + ++  I  +AFSH G  ++   E G++ +++ +  +    C K F  DG ++   IA S + Q++ACGS  G++N+YS  +C     PKP+K+I    +    L+FN +SE+LA+   A         RL+++ S TV+ NFP        R     FSPN  + ++    G   LF L HYK F
Sbjct:   76 VGSSDSLPKGIIRMKKCLHANNDRPSEDRLTTVQFHPSAQVVMTAGLDQSISLFQVDGKTNPKI-QSIHLEKFPVHKAQFSVDGEQVVATSFRNKLFYIYDMMEGKVIPVHTVRGLSEQRVKEFEVSPDGESLLLTGTSGYLHVLTMKTKEVVKSMKINGNIAGVAFSHDGSKVFTNSEEGEVYIWDMRSSK----CLKRFTDDGCVSGTSIAASKNGQYLACGSAAGVVNVYSQEECMRQNNPKPLKAIMNLVTSATSLRFNPTSEILAIASRADDEAA----RLVHIPSFTVFSNFPMFQRKTIYRAHRLDFSPNSGFFSLANNKGHAPLFRLLHYKDF 407

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Match: A0A4W5KCC3 (WD_REPEATS_REGION domain-containing protein OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 165.622 bits (418), Expect = 6.814e-42
Identity = 98/341 (28.74%), Postives = 175/341 (51.32%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + D L  G +   +C+  N D PS   ++    H +   ++TA  + ++ LF++DG+ N  + +  +L+KFP++  Q   DG+ VV  S R+  + + ++  G +  +     +  +R++  E SP G+ ++L   +  L V++  T  V+  + ++  I  +AFSH G  ++   E G++ +++ +  +    C K F  DG ++   IA S + Q++ACGS  G++N+YS  +C     PKP+K+I    +    L+FN +SE+LA+   A         RL+++ S TV+ NFP        R     FSPN  + ++    G   LF L HYK F
Sbjct:  190 VGSSDSLPKGIIRMKKCLHANNDRPSEDRLTTVQFHPSAQVVMTAGLDQSISLFQVDGKTNPKI-QSIHLEKFPVHKAQFSVDGEQVVATSFRNKLFYIYDMMEGKVIPVHTVRGLSEQRVKEFEVSPDGESLLLTGTSGYLHVLTMKTKEVVKSMKINGNIAGVAFSHDGSKVFTNSEEGEVYIWDMRSSK----CLKRFTDDGCVSGTSIAASKNGQYLACGSAAGVVNVYSQEECMRQNNPKPLKAIMNLVTSATSLRFNPTSEILAIASRADDEAA----RLVHIPSFTVFSNFPMFQRKTIYRAHRLDFSPNSGFFSLANNKGHAPLFRLLHYKDF 521

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Match: A0A4W5N2B0 (WD_REPEATS_REGION domain-containing protein OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 162.155 bits (409), Expect = 5.177e-41
Identity = 97/341 (28.45%), Postives = 174/341 (51.03%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + D L  G +   +C+  N D PS   ++    H +   ++TA  + ++ LF++DG+ N  + +  +L+KFP++  Q   DG+ VV  S R+  + + ++  G +  +     +  +R++  E SP G+ ++L   +  L V++  T  V+  + ++  I  +AFSH G  ++   E G++ +++ +  +    C   F  DG ++   IA S + Q++ACGS  G++N+YS  +C     PKP+K+I    +    L+FN +SE+LA+   A         RL+++ S TV+ NFP        R     FSPN  + ++    G   LF L HYK F
Sbjct:  122 VGSSDSLPKGIIRMKKCLHANNDRPSEDRLTTVQFHPSAQVVMTAGLDQSISLFQVDGKTNPKI-QSIHLEKFPVHKAQFSVDGEQVVATSFRNKLFYIYDMMEGKVIPVHTVRGLREQRVKEFEVSPDGESLLLTGTSGYLHVLTMKTKEVVKSMKINGNIAGVAFSHDGSKVFTNSEEGEVYIWDMRSSK----CLNRFTDDGCVSGTSIAASKNGQYLACGSAAGVVNVYSQEECMRQNNPKPLKAIMNLVTSATSLRFNPTSEILAIASRADDEAA----RLVHIPSFTVFSNFPMFQRKTIYRAHRLDFSPNSGFFSLANNKGHAPLFRLLHYKDF 453

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Match: A0A4W5N3D9 (WD_REPEATS_REGION domain-containing protein OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 163.31 bits (412), Expect = 5.317e-41
Identity = 97/341 (28.45%), Postives = 174/341 (51.03%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS-YYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + D L  G +   +C+  N D PS   ++    H +   ++TA  + ++ LF++DG+ N  + +  +L+KFP++  Q   DG+ VV  S R+  + + ++  G +  +     +  +R++  E SP G+ ++L   +  L V++  T  V+  + ++  I  +AFSH G  ++   E G++ +++ +  +    C   F  DG ++   IA S + Q++ACGS  G++N+YS  +C     PKP+K+I    +    L+FN +SE+LA+   A         RL+++ S TV+ NFP        R     FSPN  + ++    G   LF L HYK F
Sbjct:  191 VGSSDSLPKGIIRMKKCLHANNDRPSEDRLTTVQFHPSAQVVMTAGLDQSISLFQVDGKTNPKI-QSIHLEKFPVHKAQFSVDGEQVVATSFRNKLFYIYDMMEGKVIPVHTVRGLREQRVKEFEVSPDGESLLLTGTSGYLHVLTMKTKEVVKSMKINGNIAGVAFSHDGSKVFTNSEEGEVYIWDMRSSK----CLNRFTDDGCVSGTSIAASKNGQYLACGSAAGVVNVYSQEECMRQNNPKPLKAIMNLVTSATSLRFNPTSEILAIASRADDEAA----RLVHIPSFTVFSNFPMFQRKTIYRAHRLDFSPNSGFFSLANNKGHAPLFRLLHYKDF 522

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Match: A0A1A8FD63 (UTP18 small subunit (SSU) processome component homolog (Fragment) OS=Nothobranchius korthausae OX=1143690 GN=UTP18 PE=4 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 6.581e-41
Identity = 99/339 (29.20%), Postives = 173/339 (51.03%), Query Frame = 3

Query:  348 TQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFS-KRSYYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + L  G L   +C+  N   PS   ++    H +   ++TA  + +L LF++DG+ N  + +  +L++FPI+  Q   DG+ V+  S K   + + ++  G +  +     ++  R++     P G  ++L   N  L +++  T  VI  L ++  +  +AFSH G+ L+V  E G++ V++ +  R    C   F  DG +    IA S + +++ACGS  G++NIYS   C N+  PKP+K++    +    L FN SSE+LA+     +       RL++++SLTV+ NFP +      R +   FSP+  + ++    G   LF L HYK F
Sbjct:   54 SSESLPGGILRVKKCLPANSARPSEDRLTTVQFHSSAQVILTAGLDQSLSLFQVDGKTNPKI-QSIHLERFPIHKAQFSLDGETVIATSLKNKMFYLYDMMDGRVVPVHSIRGLNEARVKEFCVCPDGGELLLTGTNGYLHLLTLKTNEVIRSLKINGDVSGVAFSHDGRKLFVNSEEGEVCVWDLRNSR----CINRFSDDGCVRGTSIATSRNGRYLACGSQSGVVNIYSQEACLNSANPKPLKAVMNLLTSATSLTFNPSSEILAIA----SRVEDEAVRLVHLSSLTVFSNFPVAKRKVIYRSSCLDFSPHSGFFSLANNKGHAPLFRLLHYKDF 383

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Cavefish
Match: ENSAMXT00000008187.2 (UTP18 small subunit processome component [Source:NCBI gene;Acc:103033952])

HSP 1 Score: 149.828 bits (377), Expect = 1.027e-39
Identity = 90/340 (26.47%), Postives = 170/340 (50.00%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFS-KRSYYKVLNLATGNI----KNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP--GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + + L  G ++   C++ N ++P    ++    H +   ++TA  + T+ LF++DG+ N  + +  +L+KFP+N      +G+ VV    K   + + ++  G +    +   ++ +R++  E SP G+F++L   +  L +++  T  V+  + ++  +   AF+  G  ++   + G++ +++    R      K+ D   +    +A+S D  +VACGS  G++NIYS N C     PKP+K++    +    L+FN +SE+LA+   A         RL+++ S TV+ NFP        R     FSPN  + +V    G+  LF L HYK F
Sbjct:  148 VGSSESLPKGIIKLKMCLNANNENPGEDRLTTVQFHPSAQVVMTAGLDHTISLFQVDGKTNPKI-QSIHLEKFPVNKACFSANGEQVVATGMKNKLFYIYDMMEGKVIPVPRVRGLNEQRVKEFEVSPDGEFLLLTGSSGYLHLMTMKTREVVRSMKMNGNVCGTAFTGDGSKIFANSDEGEVFIWDV---RSSKCLNKFVDEGCVRGTSLAVSRDGLYVACGSQSGVVNIYSQNTCLQDSSPKPLKAVMNLLTAATSLRFNPNSEILAIASRAEDEAN----RLVHIPSFTVFSNFPLFRKKTIYRSHCLDFSPNSGFYSVANDKGRAVLFRLLHYKDF 479

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BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000132.1 (pep scaffold:Pmarinus_7.0:GL477008:188083:196461:-1 gene:ENSPMAG00000000113.1 transcript:ENSPMAT00000000132.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 143.665 bits (361), Expect = 3.670e-38
Identity = 93/343 (27.11%), Postives = 173/343 (50.44%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSY-YKVLNLATGNIKNL----KIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFP----GSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            L + + L  G L    CI  N+   S   ++    H +   ++TA  + +L LF++DG  N  + +  +LD+FP+   +   DG+ V+    RS  + V ++  G I  +     ++ + I+R E SP G F+++   +    ++S     ++  + V+    +  FS  GK +Y   + G++ V++   +R    C   F  DG +N   IA S D +++ACGS+ G++N+Y+ ++C +   P PIK++    ++   L FN +SE+LA+     +N      RL+++ S +V+ NFP     ++  A+    +FSP+  +L++    G   L+ L HY  F
Sbjct:  170 LASSESLPKGILRMKNCIAANQQRTSDARLTSVQFHPSAAVILTAGLDRSLSLFQVDGHTNPKI-QSVFLDRFPVYRARFSADGEKVIATGIRSKPFYVYDMIAGKITPILAIRGLEEKCIKRFELSPDGRFMMVLGTSGVQHLISLKANELVGSMKVNGQANAATFSADGKRVYTTTDEGQVYVWDVDSRR----CVNRFTDDGCVNGSSIAASPDGRYLACGSVSGVVNLYTCDECHSKPNPAPIKALMNLVTQTTSLAFNSTSEILAMA----SNEANEAARLVHVPSQSVFSNFPVFRRKTIYLAQ--MMAFSPHSGFLSIANNKGMALLYRLKHYSDF 501

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Yeast
Match: UTP18 (Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats [Source:SGD;Acc:S000003605])

HSP 1 Score: 92.0485 bits (227), Expect = 2.304e-20
Identity = 91/382 (23.82%), Postives = 162/382 (42.41%), Query Frame = 3

Query:  339 VLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLL-----PDGKNVVFFSKRSYYKVLNLATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHK---LHVSSTIKSLAFSHSGKYLYVYEEHGKIS--------------------------VFEFQEKRGPVFCRKWFDSDGIN---------------AMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGT--ARPTSFSFSPNGKYLAVGRFNGKVTLFALNHY 1328
             L+    L    L+  R  D N  HPS   I     H +K  ++T   + TL ++ IDG+ N+ V    +L   PI            + +N+    +R Y    +L+  N+ + +  T +I +       +    + EN  +  +  +  N +H    L  ++   ++  S SG +L   +  G I+                          V+EF   +     R+W D  G+                A++I+    ++++A GS  G +N+Y  N+   +  P P+ ++    + ++ LQF+   ++L +   A  +      RL+++ S +V+ N+P S GT   + TS +FSP+G  LAVG   GKV L+ LNHY
Sbjct:  221 TLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLV-TSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQ--TAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKD----ALRLVHLPSCSVFSNWPTS-GTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY 594

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Nematostella
Match: EDO47055 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNF9])

HSP 1 Score: 142.895 bits (359), Expect = 9.066e-39
Identity = 95/346 (27.46%), Postives = 178/346 (51.45%), Query Frame = 3

Query:  303 ENENKIKIQKFGVLNTQ-DFLKAGFLEFYRCIDGNRDHPSSKFISFSI-LHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNLK----IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGS-LGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTAR-PTSFSFSPNGKYLAVGRFNGKVTLF 1313
            +++++I  +    L TQ + L  G L   R  D N   P++   + S+  H +   ++TA    TL +F++DG+ N  + +  ++++FPI+      DG+ V+  S+R Y+ V ++  G +  +     +    + + + SP G  +V   +N  + ++S+ T   +  L ++ ++K + FS  G  +Y     G++ V++   +     C   F  DG +    +A S D +++ACGS  G++NIY  + C     P+P+KS+    + V   QFN SSE+LA+    ++  T   F+L+++ S+TV+ N+P S    R   +F FSPN  +L++G   G   L+
Sbjct:    2 DDDDEILARTGRNLATQSERLPKGLLSIKRVKDANAAKPANVRSTSSLEFHPSAKVLLTAGLNKTLDIFQVDGKENPKL-QSVFVNRFPIHNAHFTCDGEQVIMSSRRKYFYVYDMIKGQVTRIPGIRGMHARNLEKFKVSPDGKHLVFLGDNGYMILLSSKTKQWVGNLKMNGSVKDVTFSADGSRMYSTGSDGEVYVWDMTTRS----CVHKFVDDGCLTGTALAASKDGKYLACGSDSGIVNIYD-DQCLLQSQPRPLKSVTNLVTSVTGTQFNSSSEILAI----SSRVTKDAFKLVHLPSMTVFSNWPNSKVPLRYVNAFDFSPNSGFLSIGNDRGTAQLY 337

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Medaka
Match: ENSORLT00000023494.2 (UTP18 small subunit processome component [Source:NCBI gene;Acc:101174646])

HSP 1 Score: 146.747 bits (369), Expect = 4.355e-38
Identity = 90/341 (26.39%), Postives = 170/341 (49.85%), Query Frame = 3

Query:  342 LNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRS----YYKVLNLATGNIKNLK-IDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDG-INAMRIAISADDQFVACGSL-GLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTA--RPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            + + + L +G L+  +C+  N   PS   ++    H     ++TA  + ++ LF++DG+ N  + +  +L++FP++      DG++V+  S R+     Y ++      + +++ +   R++     P G  ++L   +  L +++  T  V+H + ++  +  +AFS  G   +   E G++ V++ +  R    C   F  DG +    IA SAD +++ACGS  G++NIYS   C ++  PKP+K++    +    L FN +SE+LA+   A         RL+++ SL+V+ NFP +      R     FSP+  + ++    G   LF L HY  F
Sbjct:  246 VGSSESLPSGILKMKKCLHANSARPSEDRLTTVQFHPTAQVVMTAGLDQSISLFQVDGKTNPKI-QSIHLERFPVHRAAFSQDGESVIATSVRNRMFYLYDMMEGRVSPVHSVRGLKETRVKEFSVCPDGGALLLTGTSGYLHLLTLKTMEVVHSMKINGNVSGVAFSRDGSKFFTNSEDGEVYVWDVRSSR----CINRFADDGCVKGTSIAASADGRYLACGSQSGVVNIYSQEACLSSANPKPLKAVMNLLTAATALAFNPTSEILAIASQAEDE----AVRLVHLRSLSVFSNFPVANRKLLHRAACLHFSPHSGFFSLANNKGHAPLFRLLHYSDF 577

[Close]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Planmine SMEST
Match: SMESG000029672.1 (SMESG000029672.1)

HSP 1 Score: 806.594 bits (2082), Expect = 0.000e+0
Identity = 420/423 (99.29%), Postives = 422/423 (99.76%), Query Frame = 3

Query:   69 MECADDFQIITTPIVVDDFEINVIKKEEXXXXXXXXXXXXXXXXXXXXXXXXXXXWIDDTEHKESGTYYSCLDIEKVLENENKIKIQKFGVLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAISADDQFVACGSLGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 1337
            MECADDFQIITTPIVVDDFEINVIKKEELKSNKSILNKVSKKSNKKKEPIKLKPKWIDDTEHKESGTYYSCLDIEKVLENENKIKIQKFGVLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFY+DKFPINGGQLLPDG NVVFFSKRSYYKVLNLATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINA+RIAISADDQFVACGSLGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF
Sbjct:    1 MECADDFQIITTPIVVDDFEINVIKKEELKSNKSILNKVSKKSNKKKEPIKLKPKWIDDTEHKESGTYYSCLDIEKVLENENKIKIQKFGVLNTQDFLKAGFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGEFNNAVDRPFYVDKFPINGGQLLPDGNNVVFFSKRSYYKVLNLATGNIKNLKIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKSLAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAIRIAISADDQFVACGSLGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSSELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTARPTSFSFSPNGKYLAVGRFNGKVTLFALNHYKAF 423

The following BLAST results are available for this feature:

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Celegans
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Fly
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Zebrafish
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Mouse
BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Cavefish
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Sea Lamprey
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Yeast
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Nematostella
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Medaka
BLAST of U3 small nucleolar RNA-associated protein 18 vs. Planmine SMEST

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
UTP18	3.888e-33	27.09	UTP18 small subunit processome component [Source:H...	[more]
UTP18	3.848e-10	32.00	UTP18 small subunit processome component [Source:H...	[more]
UTP18	1.393e-9	38.36	UTP18 small subunit processome component [Source:H...	[more]
UTP18	1.510e-7	25.00	UTP18 small subunit processome component [Source:H...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
B0280.9	7.808e-29	27.96	U3 small nucleolar RNA-associated protein 18 homol...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
wcd	8.825e-29	28.35	gene:FBgn0262560 transcript:FBtr0087170	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
utp18	1.463e-35	26.10	UTP18 small subunit processome component [Source:N...	[more]
utp18	9.827e-34	25.36	UTP18 small subunit processome component [Source:N...	[more]
utp18	6.764e-32	26.01	UTP18 small subunit processome component [Source:N...	[more]
utp18	8.425e-31	25.94	UTP18 small subunit processome component [Source:N...	[more]
utp18	4.656e-28	26.57	UTP18 small subunit processome component [Source:N...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Utp18	1.623e-38	28.37	UTP18 small subunit processome component [Source:M...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5SSI6\|UTP18_MOUSE	1.135e-37	28.37	U3 small nucleolar RNA-associated protein 18 homol...	[more]
sp\|Q9Y5J1\|UTP18_HUMAN	1.867e-32	27.09	U3 small nucleolar RNA-associated protein 18 homol...	[more]
sp\|Q9FMU5\|UTP18_ARATH	3.140e-31	26.97	U3 small nucleolar RNA-associated protein 18 homol...	[more]
sp\|Q9V7P1\|UTP18_DROME	8.846e-28	28.35	U3 small nucleolar RNA-associated protein 18 homol...	[more]
sp\|P42000\|UTP18_CAEEL	9.932e-28	27.96	U3 small nucleolar RNA-associated protein 18 homol...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4W5KCF4	1.860e-42	28.74	WD_REPEATS_REGION domain-containing protein OS=Huc...	[more]
A0A4W5KCC3	6.814e-42	28.74	WD_REPEATS_REGION domain-containing protein OS=Huc...	[more]
A0A4W5N2B0	5.177e-41	28.45	WD_REPEATS_REGION domain-containing protein OS=Huc...	[more]
A0A4W5N3D9	5.317e-41	28.45	WD_REPEATS_REGION domain-containing protein OS=Huc...	[more]
A0A1A8FD63	6.581e-41	29.20	UTP18 small subunit (SSU) processome component hom...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSAMXT00000008187.2	1.027e-39	26.47	UTP18 small subunit processome component [Source:N...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000000132.1	3.670e-38	27.11	pep scaffold:Pmarinus_7.0:GL477008:188083:196461:-...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
UTP18	2.304e-20	23.82	Small-subunit processome protein involved in pre-1...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO47055	9.066e-39	27.46	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSORLT00000023494.2	4.355e-38	26.39	UTP18 small subunit processome component [Source:N...	[more]

BLAST of U3 small nucleolar RNA-associated protein 18 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000029672.1	0.000e+0	99.29	SMESG000029672.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013876 ID=SMED30013876|Name=U3 small nucleolar RNA-associated protein 18|organism=Schmidtea mediterranea sexual|type=transcript|length=1361bp
GAAATATTTATCTGTTATTTGTTTAAATAATCAGTTTTATTACACAATTT
TTTCACATTGACTCCAATATGGAATGCGCAGATGATTTTCAAATTATTAC
AACCCCAATAGTTGTTGATGACTTCGAAATTAATGTAATCAAAAAAGAAG
AATTAAAATCTAATAAATCAATTTTAAATAAAGTTTCCAAAAAATCAAAT
AAGAAAAAAGAACCAATAAAGTTAAAGCCGAAATGGATTGATGACACAGA
ACACAAAGAATCGGGAACTTATTACAGTTGTTTAGACATAGAAAAAGTGT
TAGAAAATGAAAATAAAATAAAAATTCAAAAGTTTGGGGTATTGAACACT
CAAGATTTTCTTAAAGCAGGATTTTTAGAGTTTTATCGTTGTATCGATGG
AAATCGTGATCACCCATCTTCCAAATTTATCTCCTTTTCTATTTTGCACC
GGAACAAAATGTGCATGATTACTGCCAGCAATGAAGGCACTTTGTGTCTT
TTTAAAATCGATGGGGAATTTAATAATGCAGTTGATAGGCCATTTTACCT
GGATAAATTTCCTATCAACGGCGGCCAATTGCTCCCTGACGGAAAAAATG
TCGTTTTCTTTAGCAAACGGAGTTATTACAAAGTTCTAAATCTCGCAACG
GGTAACATAAAGAACTTAAAAATCGACACGGAAAGAATCCGGCGGTTGGA
GGCGTCTCCGTCGGGGGATTTTATCGTGCTTGCCAATGAGAACACGACGC
TGTTTGTGGTGAGCACTGCCACATTCAATGTCATCCATAAGCTCCACGTA
TCCAGCACAATCAAGTCGCTCGCGTTCTCACACAGCGGGAAATATCTCTA
TGTCTATGAAGAGCACGGGAAAATATCCGTATTCGAATTCCAGGAGAAGC
GCGGCCCAGTTTTCTGCAGGAAATGGTTTGACAGCGACGGCATCAACGCC
ATGAGGATCGCCATCAGTGCTGATGATCAGTTTGTCGCATGTGGCAGTCT
CGGCCTCCTCAACATTTACAGCCTCAATGACTGCTGGAATACCGAGTACC
CGAAACCCATCAAGTCAATCCAGTATCCAGACAGCCGAGTCAACCAGCTC
CAATTCAACCATTCCAGCGAGCTGCTTGCGGTCGGGTTCTCAGCGACTGC
CAACACGACAACCGGCGGATTCCGCCTCCTCAATATGGCGTCGTTAACGG
TCTATCATAACTTCCCCGGGTCGGTCGGAACGGCAAGGCCGACGAGCTTC
TCATTCAGTCCCAATGGGAAATATCTCGCAGTCGGCAGGTTCAACGGCAA
GGTCACGCTATTTGCACTCAATCACTACAAGGCGTTTTAATAAACATTTA
TTGATCTAAAA

protein sequence of SMED30013876-orf-1

>SMED30013876-orf-1 ID=SMED30013876-orf-1|Name=SMED30013876-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=424bp
MECADDFQIITTPIVVDDFEINVIKKEELKSNKSILNKVSKKSNKKKEPI
KLKPKWIDDTEHKESGTYYSCLDIEKVLENENKIKIQKFGVLNTQDFLKA
GFLEFYRCIDGNRDHPSSKFISFSILHRNKMCMITASNEGTLCLFKIDGE
FNNAVDRPFYLDKFPINGGQLLPDGKNVVFFSKRSYYKVLNLATGNIKNL
KIDTERIRRLEASPSGDFIVLANENTTLFVVSTATFNVIHKLHVSSTIKS
LAFSHSGKYLYVYEEHGKISVFEFQEKRGPVFCRKWFDSDGINAMRIAIS
ADDQFVACGSLGLLNIYSLNDCWNTEYPKPIKSIQYPDSRVNQLQFNHSS
ELLAVGFSATANTTTGGFRLLNMASLTVYHNFPGSVGTARPTSFSFSPNG
KYLAVGRFNGKVTLFALNHYKAF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000429	neoblast
PLANA:0002056	medial muscle cell
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036322	WD40_repeat_dom_sf
IPR001680	WD40_repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR017986	WD40_repeat_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001680	WD40 repeat	SMART	SM00320	WD40_4	coord: 280..318 e-value: 420.0 score: 0.4 coord: 102..146 e-value: 400.0 score: 0.6 coord: 375..416 e-value: 2.5 score: 14.5 coord: 235..273 e-value: 6.0 score: 12.1 coord: 193..232 e-value: 310.0 score: 1.3
IPR015943	WD40/YVTN repeat-like-containing domain superfamily	GENE3D	G3DSA:2.130.10.10		coord: 97..418 e-value: 6.4E-53 score: 182.0
None	No IPR available	PANTHER	PTHR18359:SF0	U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG	coord: 38..422
None	No IPR available	PANTHER	PTHR18359	WD-REPEAT PROTEIN-RELATED	coord: 38..422
IPR036322	WD40-repeat-containing domain superfamily	SUPERFAMILY	SSF50978	WD40 repeat-like	coord: 123..417

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U3 small nucleolar RNA-associated protein 18

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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