E3 ubiquitin-protein ligase

Overview


Name	E3 ubiquitin-protein ligase
Smed ID	SMED30013828
Length (bp)	5796

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of E3 ubiquitin-protein ligase (SMED30013828) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase (SMED30013828) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase (SMED30013828) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase (SMED30013828) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013828

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30013828	h1SMcG0009287	Contig5258	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30013828	h1SMcG0019767	Contig5258	GPL15192	PMID:23079596 Forsthoefel et al., 2012
cephalic ganglia	SMED30013828	h1SMcG0009287	tr5_16130	mu_Smed_v1	PMID:25558068 Reuter et al., 2015
nervous system	SMED30013828	h1SMcG0009287	dd_Smed_v4_4236_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30013828	h1SMcG0009287	dd_Smed_v4_4236_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: UBR2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:HGNC Symbol;Acc:HGNC:21289])

HSP 1 Score: 335.109 bits (858), Expect = 3.403e-92
Identity = 353/1282 (27.54%), Postives = 576/1282 (44.93%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK----------KDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  +     +  + +V+  EDV +    N  AI+   F+Y           L+ EK + EL  + E         KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  I++ QN  + +L WL   I     LR +LC     E          E S+L+  +  +  ++WK AR+V     M+++  +  +KKLF V+ A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I+K   +        LRH++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++      S+     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK+       K V+Q+     E+ L+ +I+ +  R   GVG+ V   D     I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP+        A L+N + +     ++   L   +   NG  W++++L  VL+LIG +L E+ ++LE   EE    F F   I++  +       I+  LE L +    +   ++I+WI++  N +K M+ S   S   E     ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  PVA D          + V ++  F TCILCQ E+  +  +R +VL A   RS VL+K+          +S   QD                         P + D   M   +S   H      ++CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++    ++ N   N     +   W+ T+SQ
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVHLSEDV-IARTYNIFAIT---FRYAVEI-------LTWEKES-ELPADLEMVE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCEQAKSVI-VRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSLARMLITEENLMSIIIKTFMDH-------LRHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGG-YTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQ-VNATDEIKREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIEAVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEH-NGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKN----------RSKFIQD-------------------------PEKYDPLFMHPDLSCGTHT-----SSCGHIMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQ 1252

HSP 2 Score: 101.293 bits (251), Expect = 1.785e-20
Identity = 74/245 (30.20%), Postives = 110/245 (44.90%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM-PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
             ++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K +       +  P    KLI+LP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E + K+++ W  HS+   I     +N   V
Sbjct: 1511 GIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSLPNNLICLFQENSEIMNSL-IESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQ--TELEGEDVGACTAHTYSCGSGVGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: UBR2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:HGNC Symbol;Acc:HGNC:21289])

HSP 1 Score: 328.176 bits (840), Expect = 3.994e-90
Identity = 349/1282 (27.22%), Postives = 573/1282 (44.70%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK----------KDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  +     +  + +V+  EDV +    N  AI+   F+Y           L+ EK + EL  + E         KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  I++ QN  + +L WL   I     LR +LC     E          E S+L+  +  +  ++WK AR+V     M+++  +  +KKLF V+ A+NY+ +   +  DDH    S+ +L+ Q FT  + A+ L+   N M  I+K   +        LRH++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++      S+     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK+       K V+Q+     E+ L+ +I+ +  R   GVG+ V   D     I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP+        A L+N + +     ++   L   +   NG  W++++L  VL+LIG +L E+ ++LE   EE    F F   I++  +       I+  LE L +    +   ++I+WI++  N +K M+ S   S   E     ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  PVA D          + V ++  F TCILCQ E+  +  +R +VL A   RS VL+K+          +S   QD                         P + D   M   +S   H      ++CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++    ++ N   N     +   W+ T+SQ
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVHLSEDV-IARTYNIFAIT---FRYAVEI-------LTWEKES-ELPADLEMVE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCEQAKSVI-VRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMSIIIKTFMDH-------LRHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGG-YTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQ-VNATDEIKREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIEAVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEH-NGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKN----------RSKFIQD-------------------------PEKYDPLFMHPDLSCGTHT-----SSCGHIMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQ 1252

HSP 2 Score: 101.293 bits (251), Expect = 1.785e-20
Identity = 74/245 (30.20%), Postives = 110/245 (44.90%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM-PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
             ++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K +       +  P    KLI+LP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E + K+++ W  HS+   I     +N   V
Sbjct: 1511 GIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSLPNNLICLFQENSEIMNSL-IESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQ--TELEGEDVGACTAHTYSCGSGVGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: UBR1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol;Acc:HGNC:16808])

HSP 1 Score: 303.138 bits (775), Expect = 2.623e-82
Identity = 315/1269 (24.82%), Postives = 537/1269 (42.32%), Query Frame = 1

Query:  175 FESFEKFIIGRNDKSIIESNVSSS---ICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAK--------LIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVT---------ETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR---AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLE----LIKWIIRKCNEIK-LMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFIN------ENSELLTEKKD------QHPVACDEDHV------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPII 3795
            F   E ++ G +    +E    S    +CG++FK+ E  Y CRDCA D TCVLC  CF  S H  H Y+MHTS+GGG+CDCGD EAWK    C  H      +              P++ ++  +  ++ IF     +V+        ++   EL++ +          K++    VL+N+E H+++ VI   +R L C    A  +   +D++GR  A+ +      +  K +I   S++ +   L   + H  I++ Q   + +  W+ + +      R + C     E      E   E   LI  +     +++K AR +    I ++ F E  +KKLF ++  + YK +   Y  DDH+   S+ +L+ Q+FTV + A++L+E  N +  I + +   L EY                     +D N KF       D   R    + DLK++L S                       IW +     F++ F++F   L+ +Q  + I R +  H+E DP+W+  + +     N + +  +        L+V+ ++C +        F  +    ++   C   +L + S  V E+      +S+  PL R +A L + +     ++           + + L++  L+ LV  +Q    MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F+L  + +++L       +  + D+  + Q     E+ L  LI  +  R+  GVG NVTKE++    I+H LC++ M HS + K L  +     +  L N+I+KVA      +S   V     +S  L DF+ Y  +YS    ++AE   K   K+E     + PP P +     ++++N ++      +L       I   + + WT+ +L M  +++   LLE+ + L+   EE+  + FD     S       N+++L +K+    QLE    +I WI++  + +K L + S  +  +    E+  ND          +  KA+AA+  R+ +M++M  +QK FI       +N+  +  K+D        P   D   +        +V +K   TCILCQ E+  +  N  +VL A   +S  L +H                                          P E+    +  +    D A  T+  +CGHVMH  C   Y + +    Q                CPLCK +CN  IPII
Sbjct:   71 FTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSR-------CPLNEEV--IVQARKIFPSVIKYVVEMTIWEEEKELPPELQIRE----------KNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGR-RAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLRE------EPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEY---------------------LDRNNKFNFQGYSQDKLGRVYAVICDLKYILIS--------------------KPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQ--SC-GHSLETKSYRVSED-----LVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYY--QDVKC---REEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTK-DQDLIKQYNTLIEEMLQVLIYIVGERYVPGVG-NVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENN--ETGLENVINKVATFKKPGVSGHGVYELKDES--LKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAIDT-DSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEE--VTFDFYHKASRLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQH---------------------------------------RGKPIELSGEALDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPII 1211

HSP 2 Score: 90.1225 bits (222), Expect = 4.669e-17
Identity = 53/151 (35.10%), Postives = 76/151 (50.33%), Query Frame = 1

Query: 5041 PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVIND 5493
            P     LI+LP++++ ++       C  S  A        LCL CG  +C    CC+ I   +G  +     HA  C  G  +FL  R  +VV++  +AR   Y  P YLD++GE+D  LKRGNPL L++E Y KL   W  H   C+I +
Sbjct: 1588 PRKRNSLIELPDDYSCLLNQASHFRCPRS--ADDERKHPVLCLFCGAILCSQNICCQEI--VNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAP-YLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQH---CIIEE 1730

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: UBR1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol;Acc:HGNC:16808])

HSP 1 Score: 271.937 bits (694), Expect = 4.185e-74
Identity = 272/1079 (25.21%), Postives = 478/1079 (44.30%), Query Frame = 1

Query:  175 FESFEKFIIGRNDKSIIESNVSSS---ICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAK--------LIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVT---------ETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR---AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLE----LIKWIIRKCNEIK-LMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHP 3282
            F   E ++ G +    +E    S    +CG++FK+ E  Y CRDCA D TCVLC  CF  S H  H Y+MHTS+GGG+CDCGD EAWK    C  H      +              P++ ++  +  ++ IF     +V+        ++   EL++ +          K++    VL+N+E H+++ VI   +R L C    A  +   +D++GR  A+ +      +  K +I   S++ +   L   + H  I++ Q   + +  W+ + +      R + C     E      E   E   LI  +     +++K AR +    I ++ F E  +KKLF ++  + YK +   Y  DDH+   S+ +L+ Q+FTV + A++L+E  N +  I + +   L EY                     +D N KF       D   R    + DLK++L S                       IW +     F++ F++F   L+ +Q  + I R +  H+E DP+W+  + +     N + +  +        L+V+ ++C +        F  +    ++   C   +L + S  V E+      +S+  PL R +A L + +     ++           + + L++  L+ LV  +Q    MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F+L  + +++L       +  + D+  + Q     E+ L  LI  +  R+  GVG NVTKE++    I+H LC++ M HS + K L  +     +  L N+I+KVA      +S   V     +S  L DF+ Y  +YS    ++AE   K   K+E     + PP P +     ++++N ++      +L       I   + + WT+ +L M  +++   LLE+ + L+   EE+  + FD     S       N+++L +K+    QLE    +I WI++  + +K L + S  +  +    E+  ND          +  KA+AA+  R+ +M++M  +QK FI E  +L+ +   + P
Sbjct:   71 FTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSR-------CPLNEEV--IVQARKIFPSVIKYVVEMTIWEEEKELPPELQIRE----------KNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGR-RAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLRE------EPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEY---------------------LDRNNKFNFQGYSQDKLGRVYAVICDLKYILIS--------------------KPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQ--SC-GHSLETKSYRVSED-----LVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYY--QDVKC---REEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTK-DQDLIKQYNTLIEEMLQVLIYIVGERYVPGVG-NVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENN--ETGLENVINKVATFKKPGVSGHGVYELKDES--LKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAI-DTDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEE--VTFDFYHKASRLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFI-ETHKLMYDNTSEMP 1059

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: UBR2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:HGNC Symbol;Acc:HGNC:21289])

HSP 1 Score: 182.956 bits (463), Expect = 6.031e-49
Identity = 128/363 (35.26%), Postives = 190/363 (52.34%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISF 1314
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  +     +  + +V+  EDV +    N  AI+   F+Y           L+ EK + EL  + E         KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  I++ QN  + +L WL   I     LR +LC     E          E S+L+  +  +  ++WK AR+V     M+++  +  +KKLF V+ A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S 
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVHLSEDV-IARTYNIFAIT---FRYAVEI-------LTWEKES-ELPADLEMVE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCEQAKSVI-VRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSL 427

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: ubr-1 (E3 ubiquitin-protein ligase ubr-1 [Source:UniProtKB/Swiss-Prot;Acc:P91133])

HSP 1 Score: 145.976 bits (367), Expect = 1.684e-34
Identity = 230/1021 (22.53%), Postives = 404/1021 (39.57%), Query Frame = 1

Query: 1081 TLIQDIFENHIEMWKSARNVCTNFIMTTIF----KETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDP-FERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIER-VIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWER----AFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYR--------------NQLNVTE-TDC-----LLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAP----EMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIV--GKQSDK----------KAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD--QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKK-EGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFI---------------NENSELLTEKKD---QH--------------PVACDEDHVDSNVHKKLDFTCILCQEKN--TEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMS------FQNWM 3858
            T++++I     +MWK+ R++    +M T+F    ++  F K F++    +Y  I   +  DDH  + S++ L+ Q  TV S A+ L+        I K I ++  ++ K      I       F       ++ F P   R +    D+ ++L ++ S                   + W    +D F++ F  F  FL  +Q  D ++R  +EH V  +  W+T   ++    + I++      +N +   R      E++ +         E  Y  T  +   S  +   +      SV +P+ R +A L     Y               NQ  + E  +C     L + +L++LV C+Q +  +W RNG   + L  QI     +P    EMFDRD+ ++Q+ A   P   FI   +H+F L  + T      K ++K          K ++  AE+F+  LI+ L  R+  GVGK     D     ++H LC  S + S + +K+S  +    +  L   ++ VAD  + L++    F+ K+S  L  +  +  +YS  D++ AE S      K E       PPI  D      ++   ++      ++   L I  T       +D +    LYLIG +L E+ KN      ++              + ++  LE L  K        L++  + K    KL+K    V  +  A E      +  Q   ++K  +A  A + R+  M+KM NMQ KF+               +E SE + +K D   +H              PV    +   + + K    TCILCQE      +  +P+V  A   +S +              ++ N + +T     +   ++ +  ++L      + +D                  ++TC H MHY+C  S  +     +   AR  G    ++ +      +CPLCK + N  IP++ +  L    N  S++S      F  W+
Sbjct:  443 TMLENILLQDTQMWKAGRSILHQMLMRTVFMIYDQKVRFAKAFML----HYNEIYEDFIKDDHEMDVSVVGLSVQFMTVPSLARKLVAEDQAFSVISKAIRDQTDKFVKYYNDGKIAR---FDF------TSRSFPPELRRSLHITRDMAYILNAVPSE------------------SDWNRELIDGFVQGFADFLLFLQHLQGMDEVKRQAVEHQV-WESEWETAFNILLRLKDAISMIIGWAETNEEVHNRLMIMCLELMNRMPPVYTKSEEDTYELTVTINGESCRISHFDVLKSSTSVHQPVVRIIAGLFSASNYTGFLLNRSNNSHTSLNQERIKELINCKDETNLYELSLRVLVLCAQSNATLWRRNG---FSLINQIHNY-FSPLCRNEMFDRDVLMMQVGAALTPSTKFIFHLLHRFRLFKWATSEFEQDKANEKPAKPESEDLSKTLVMIAEEFIQCLILILCERYTYGVGK-TRPMDQMKREVIHILCTGSHTFSHIQQKMSHDINSK-RLSLHEAVNLVADFRKPLATTAGQFHCKES-SLPTYSPFFMHYSKSDQSAAEQSQARVRAKMEKSVRACAPPILPDFQTFFERIPEILTTNVLIHVVR--LIIDRTARRSRFSSDRLFHKTLYLIGIALNEEEKNPSFGFTQR----------AEESIGLLSLLEGLVGKPESSICPILLEVTVEKYR--KLIKARAGVPEAAPAPEN-----KPAQSEEEIKAKRAARAAEMRQKAMAKMSNMQSKFMKKIEDEEKKDESQTPSEKSETVVKKDDYDNKHFFDEDVVKQVGHDFPVCIGANKWHAELVKPRTLTCILCQEDEIIAPQQGKPMVCAAFIQQSQLFTH-----------KNKNGELMTASSGTISTRDLLTAPATLQ-----YGVD------------------VSTCSHSMHYECYRSLAEANRSRESLRARQVGQHSHKMVDTENGEYQCPLCKRLSNAAIPVLPAYQLTN-QNGFSTVSGAGKENFDTWV 1370

HSP 2 Score: 142.124 bits (357), Expect = 2.459e-33
Identity = 96/296 (32.43%), Postives = 143/296 (48.31%), Query Frame = 1

Query:  205 RNDKSIIES---------NVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFAS-KHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCM------ALTSTDQKDIESK--KNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFS 1038
            RN KS +E+              ICG +FK  E  Y C DCATD TCV+C  CF  S H  H Y+MH+SSG GYCDCGD +AW     C  H        D  E  V   E     +K     + + I ++           LS+    ++LK+ + F   K   + ++++   VLYN+E H +E VI + +  + CT ++AM  A IVDR+GR        A  +  + D++ K  ++  S+R  S   + L  ++    + +LQN  I +L WL   +D +P LR ++   L S
Sbjct:   71 RNTKSTLEAMNGIAGVDPARRGQICGHVFKNGELTYTCLDCATDGTCVMCLQCFEVSIHKSHKYKMHSSSGSGYCDCGDADAWTEGYACANH-----EKKDDEEAAVLAPE-----LKKRCEQLVEIILQF----------SLSMITHKDDLKLPEIFEKMKPEVTNEAQQYLTVLYNDETHTYESVIKVLELYIHCTKDQAMLVATIVDREGRSAVKLGSKADCTKAKDDVQRKTARDPTSIRRSSNHNLPLSVKVMDTTLFALQNFSISLLTWLNTQMDVFPPLREIVGEILLS 346

HSP 3 Score: 102.449 bits (254), Expect = 3.343e-21
Identity = 71/234 (30.34%), Postives = 101/234 (43.16%), Query Frame = 1

Query: 4807 SFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPH---------VMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            S LR    + H +  VD P             LFR L L          P  I  Q   IS   L +  T W++ +P          V P  P  L++LP +++++I       C   P    T +  +LCLVCG  +C   YCC++I     +     + H  QC     +FL  R+  +V++  + R      P Y+D+FGE D   +RGNPL LN E Y KL+  WL   I
Sbjct: 1819 SLLRPIALLYHFITLVDPPEALKDPSINSSEPLFRYLGL----------PHKIEEQ---ISGSMLEKLFTMWSSSIPSDQALRQDLVVQPVRPNLLVELPEKYSQLINQVATFKCPTIPIEESTSNVPTLCLVCGTILCSQAYCCQKIINKQSY--GACRYHMSQCSGSVGMFLRVRDCSLVLMTTRKRGCFRPAP-YVDEFGEVDQGFRRGNPLHLNPELYQKLKSLWLQQGI 2036

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: F10G7.10 (pep chromosome:WBcel235:II:4713674:4726264:-1 gene:WBGene00017373.1 transcript:F10G7.10a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.10)

HSP 1 Score: 66.6254 bits (161), Expect = 2.055e-10
Identity = 62/230 (26.96%), Postives = 101/230 (43.91%), Query Frame = 1

Query: 4801 LLSFLRIAVFMLHE--LGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPS----WISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSG----FTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNW 5460
            L+ FLR +  +L    LG  D+     +    I+L  VL+L  I   N + P     W       ++++  ++ K  +   +   + + P +++  P  F E+      R C+   + S   S   +CL CG  +CL   CCR   + SG     ++S  + HA  C     LFL+   +  +V+  + +       IYLD   E D +LKRG PLFL +     LE +W
Sbjct: 1774 LIEFLRFSYELLFHCNLGFNDVNN--QIHSRNIDLDNVLRLVGINAQNINVPGKANYWTRAFRTQLTNM--AKLKRIFQPCIVEPLAWKPRRILKPPTNFDELFGRYFHRECN---KCSSVPSYPVMCLFCGEILCLND-CCRMAHQESGSDRVISMSEIEAHAEDCSSSSGLFLSV--TSSMVVVSRGKQAAIWGTIYLDAHKEEDRNLKRGKPLFLCESRLKWLEYDW 1993

HSP 2 Score: 53.1434 bits (126), Expect = 2.831e-6
Identity = 28/85 (32.94%), Postives = 40/85 (47.06%), Query Frame = 1

Query:  214 KSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLK 468
            K  ++ N  S  C +I++     + C  CA      LC  CF  + H  H+Y    S  GG CDCG+++  K   +C  HGD  K
Sbjct:  127 KQKMKENDFSLKCNEIWENDAVAFRCNTCALTPCMSLCEDCFESNGHAGHDYTRFFSREGGACDCGNQDVIKEQGNCKNHGDESK 211

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: F10G7.10 (pep chromosome:WBcel235:II:4713674:4726264:-1 gene:WBGene00017373.1 transcript:F10G7.10b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.10)

HSP 1 Score: 53.1434 bits (126), Expect = 3.027e-6
Identity = 28/85 (32.94%), Postives = 40/85 (47.06%), Query Frame = 1

Query:  214 KSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLK 468
            K  ++ N  S  C +I++     + C  CA      LC  CF  + H  H+Y    S  GG CDCG+++  K   +C  HGD  K
Sbjct:  127 KQKMKENDFSLKCNEIWENDAVAFRCNTCALTPCMSLCEDCFESNGHAGHDYTRFFSREGGACDCGNQDVIKEQGNCKNHGDESK 211

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: F10G7.10 (pep chromosome:WBcel235:II:4718646:4726264:-1 gene:WBGene00017373.1 transcript:F10G7.10c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.10)

HSP 1 Score: 53.1434 bits (126), Expect = 3.066e-6
Identity = 28/85 (32.94%), Postives = 40/85 (47.06%), Query Frame = 1

Query:  214 KSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLK 468
            K  ++ N  S  C +I++     + C  CA      LC  CF  + H  H+Y    S  GG CDCG+++  K   +C  HGD  K
Sbjct:  127 KQKMKENDFSLKCNEIWENDAVAFRCNTCALTPCMSLCEDCFESNGHAGHDYTRFFSREGGACDCGNQDVIKEQGNCKNHGDESK 211

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Ubr1 (gene:FBgn0030809 transcript:FBtr0346190)

HSP 1 Score: 222.631 bits (566), Expect = 7.666e-58
Identity = 290/1259 (23.03%), Postives = 536/1259 (42.57%), Query Frame = 1

Query:  190 KFIIGRNDKSIIE----SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVD-VKINFLAISKSIFKYFKNFVMRPLCKLS-LEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQ---KDIESKKNEI----SVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPD----NAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEI-LRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRNQLNVTETDCL---------LDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQ------IKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYL-----TGIVGKQSDKKAVLQRA--EDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEI--KLMKNSGHVSTSFEAMETDNN-DLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSY-----MKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKS 3801
            +F++G N  S +E       ++++CGK+FK  EP Y CR+C  D TCVLC  CF +S H  H Y+M TS GGG CDCGD+EAWK   +C LH  + K+  +S       L D  ++ V+I F AI      Y +   + P   L  L+   E  +V+              +   VLYN+E H F+QVI    +  +C  + AM     +DR+GR +    T +   K   S +N++    S+ S ++    L   + H   ++ Q   + +L W  EF+ ++         YLF +   ++ +   +++  I+ I E  +++WK+AR      +++ +  E   K +   + ++ Y  I+  +  DDH+   S++SL+ QLFTV S A +L+      D ++   Y+  IE       + I N+  LHF K    +      F+R    L DL++LL                        ++ PD    +  + F++  +     L+++Q  +++ R    H++++P W+    +       I+        + +   + +++ +R       +    K  Q   +  +  + +  +   + +S+  PL RF A + +     D+ Y      TET+ L         ++  L      +Q    +W RNG   Y L  Q      ++C     EM DRD+  LQ+ A  +    F++  +++F+ + +L     + + G + +   + + +  ++FL  LI+ +  R   GV   VT+ED     I+  LC+K  SHS+L + L              +I+ VA   + + +        K  +L +F+ Y  +Y+ +D+++AE   +   K +   +   PP+   LT     + N +  P +  + +  +   +      ++T++ L  VL+L+G ++ E+       L E  P  F +   +S +  I+  LE L      +   + + W I +  ++  K   + G    S     T     L   +   + +  +A  A +RR  +M++M   QK FI+ N+E+  + +       +E   +S     +D+  I  +E+                    +A    ++ L P  +  +  D T       +N   S        S   +  R  + +  ++ +      I+ CGHVMHY C   Y      KE+ +  +N  R        +  +CP C+ + N  IP+ ++
Sbjct:   85 EFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESK-----ILTDAVLERVEICFGAILAFCVSYLE---IEPNASLQCLDGNVEGGQVD------------GAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRH---------YLFRKTFSELVQRK-QETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIE-------KFIRNK-TLHFSKNIASLTF----FKRANYILYDLRYLL------------------------SLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYDGL--QTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNG---YTLLHQLYFYRNVRCRV---EMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSM-VTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNA-YSRSFTESHLQKVLHLLGYAIQEE-------LSEHYP--FLSFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTE-------NETRKESASTGPMDWEDIPPEEEQ-----------------GAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSR-VIFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRN--RAALAQAANVEFQCPYCRTLSNAIIPVTET 1231

HSP 2 Score: 86.2705 bits (212), Expect = 3.380e-16
Identity = 48/142 (33.80%), Postives = 76/142 (53.52%), Query Frame = 1

Query: 5053 PKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQ-IYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            P+L  L ++F+++I    D  C  + +       M  CL+CG+ +C   YCC+   E    ++     HA  C     +FL  R+ +VV   Y  R +  ++ P YLD++GE+D+ L+RGNPL L+Q AY K+   WL H +
Sbjct: 1668 PRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTM--CLICGLILCGQSYCCQ--PELGKVSVGACTHHAHACGAEVGIFLRIRDCQVV---YLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGL 1802

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Ubr1 (gene:FBgn0030809 transcript:FBtr0308839)

HSP 1 Score: 222.631 bits (566), Expect = 7.666e-58
Identity = 290/1259 (23.03%), Postives = 536/1259 (42.57%), Query Frame = 1

Query:  190 KFIIGRNDKSIIE----SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVD-VKINFLAISKSIFKYFKNFVMRPLCKLS-LEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQ---KDIESKKNEI----SVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPD----NAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEI-LRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRNQLNVTETDCL---------LDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQ------IKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYL-----TGIVGKQSDKKAVLQRA--EDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEI--KLMKNSGHVSTSFEAMETDNN-DLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSY-----MKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKS 3801
            +F++G N  S +E       ++++CGK+FK  EP Y CR+C  D TCVLC  CF +S H  H Y+M TS GGG CDCGD+EAWK   +C LH  + K+  +S       L D  ++ V+I F AI      Y +   + P   L  L+   E  +V+              +   VLYN+E H F+QVI    +  +C  + AM     +DR+GR +    T +   K   S +N++    S+ S ++    L   + H   ++ Q   + +L W  EF+ ++         YLF +   ++ +   +++  I+ I E  +++WK+AR      +++ +  E   K +   + ++ Y  I+  +  DDH+   S++SL+ QLFTV S A +L+      D ++   Y+  IE       + I N+  LHF K    +      F+R    L DL++LL                        ++ PD    +  + F++  +     L+++Q  +++ R    H++++P W+    +       I+        + +   + +++ +R       +    K  Q   +  +  + +  +   + +S+  PL RF A + +     D+ Y      TET+ L         ++  L      +Q    +W RNG   Y L  Q      ++C     EM DRD+  LQ+ A  +    F++  +++F+ + +L     + + G + +   + + +  ++FL  LI+ +  R   GV   VT+ED     I+  LC+K  SHS+L + L              +I+ VA   + + +        K  +L +F+ Y  +Y+ +D+++AE   +   K +   +   PP+   LT     + N +  P +  + +  +   +      ++T++ L  VL+L+G ++ E+       L E  P  F +   +S +  I+  LE L      +   + + W I +  ++  K   + G    S     T     L   +   + +  +A  A +RR  +M++M   QK FI+ N+E+  + +       +E   +S     +D+  I  +E+                    +A    ++ L P  +  +  D T       +N   S        S   +  R  + +  ++ +      I+ CGHVMHY C   Y      KE+ +  +N  R        +  +CP C+ + N  IP+ ++
Sbjct:   85 EFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESK-----ILTDAVLERVEICFGAILAFCVSYLE---IEPNASLQCLDGNVEGGQVD------------GAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRH---------YLFRKTFSELVQRK-QETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIE-------KFIRNK-TLHFSKNIASLTF----FKRANYILYDLRYLL------------------------SLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYDGL--QTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNG---YTLLHQLYFYRNVRCRV---EMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSM-VTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNA-YSRSFTESHLQKVLHLLGYAIQEE-------LSEHYP--FLSFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTE-------NETRKESASTGPMDWEDIPPEEEQ-----------------GAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSR-VIFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRN--RAALAQAANVEFQCPYCRTLSNAIIPVTET 1231

HSP 2 Score: 86.2705 bits (212), Expect = 3.380e-16
Identity = 48/142 (33.80%), Postives = 76/142 (53.52%), Query Frame = 1

Query: 5053 PKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQ-IYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            P+L  L ++F+++I    D  C  + +       M  CL+CG+ +C   YCC+   E    ++     HA  C     +FL  R+ +VV   Y  R +  ++ P YLD++GE+D+ L+RGNPL L+Q AY K+   WL H +
Sbjct: 1668 PRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTM--CLICGLILCGQSYCCQ--PELGKVSVGACTHHAHACGAEVGIFLRIRDCQVV---YLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGL 1802

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Ubr1 (gene:FBgn0030809 transcript:FBtr0074415)

HSP 1 Score: 222.631 bits (566), Expect = 7.666e-58
Identity = 290/1259 (23.03%), Postives = 536/1259 (42.57%), Query Frame = 1

Query:  190 KFIIGRNDKSIIE----SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVD-VKINFLAISKSIFKYFKNFVMRPLCKLS-LEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQ---KDIESKKNEI----SVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPD----NAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEI-LRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRNQLNVTETDCL---------LDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQ------IKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYL-----TGIVGKQSDKKAVLQRA--EDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEI--KLMKNSGHVSTSFEAMETDNN-DLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSY-----MKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKS 3801
            +F++G N  S +E       ++++CGK+FK  EP Y CR+C  D TCVLC  CF +S H  H Y+M TS GGG CDCGD+EAWK   +C LH  + K+  +S       L D  ++ V+I F AI      Y +   + P   L  L+   E  +V+              +   VLYN+E H F+QVI    +  +C  + AM     +DR+GR +    T +   K   S +N++    S+ S ++    L   + H   ++ Q   + +L W  EF+ ++         YLF +   ++ +   +++  I+ I E  +++WK+AR      +++ +  E   K +   + ++ Y  I+  +  DDH+   S++SL+ QLFTV S A +L+      D ++   Y+  IE       + I N+  LHF K    +      F+R    L DL++LL                        ++ PD    +  + F++  +     L+++Q  +++ R    H++++P W+    +       I+        + +   + +++ +R       +    K  Q   +  +  + +  +   + +S+  PL RF A + +     D+ Y      TET+ L         ++  L      +Q    +W RNG   Y L  Q      ++C     EM DRD+  LQ+ A  +    F++  +++F+ + +L     + + G + +   + + +  ++FL  LI+ +  R   GV   VT+ED     I+  LC+K  SHS+L + L              +I+ VA   + + +        K  +L +F+ Y  +Y+ +D+++AE   +   K +   +   PP+   LT     + N +  P +  + +  +   +      ++T++ L  VL+L+G ++ E+       L E  P  F +   +S +  I+  LE L      +   + + W I +  ++  K   + G    S     T     L   +   + +  +A  A +RR  +M++M   QK FI+ N+E+  + +       +E   +S     +D+  I  +E+                    +A    ++ L P  +  +  D T       +N   S        S   +  R  + +  ++ +      I+ CGHVMHY C   Y      KE+ +  +N  R        +  +CP C+ + N  IP+ ++
Sbjct:   85 EFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESK-----ILTDAVLERVEICFGAILAFCVSYLE---IEPNASLQCLDGNVEGGQVD------------GAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRH---------YLFRKTFSELVQRK-QETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIE-------KFIRNK-TLHFSKNIASLTF----FKRANYILYDLRYLL------------------------SLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYDGL--QTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNG---YTLLHQLYFYRNVRCRV---EMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSM-VTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNA-YSRSFTESHLQKVLHLLGYAIQEE-------LSEHYP--FLSFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTE-------NETRKESASTGPMDWEDIPPEEEQ-----------------GAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSR-VIFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRN--RAALAQAANVEFQCPYCRTLSNAIIPVTET 1231

HSP 2 Score: 86.2705 bits (212), Expect = 3.380e-16
Identity = 48/142 (33.80%), Postives = 76/142 (53.52%), Query Frame = 1

Query: 5053 PKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQ-IYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            P+L  L ++F+++I    D  C  + +       M  CL+CG+ +C   YCC+   E    ++     HA  C     +FL  R+ +VV   Y  R +  ++ P YLD++GE+D+ L+RGNPL L+Q AY K+   WL H +
Sbjct: 1668 PRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTM--CLICGLILCGQSYCCQ--PELGKVSVGACTHHAHACGAEVGIFLRIRDCQVV---YLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGL 1802

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Ubr3 (gene:FBgn0260970 transcript:FBtr0331299)

HSP 1 Score: 87.8113 bits (216), Expect = 1.173e-16
Identity = 67/245 (27.35%), Postives = 101/245 (41.22%), Query Frame = 1

Query: 4804 LSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLD----------------LIPFSNYSYPSWISNQL-------KLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNH 5469
            L FLR+A  +   L   ++P       EF+ L   L+L                  IP +  + P +   QL         + +L L    + W  P          +L++LP E+  + T   +R C           E S+CL+CG  VCL   CC   D         A  H   C  G  +FL   ++ ++V+  + R       +YLD F E D DLKRG PL+L+++ +  LE  WL+H
Sbjct: 1979 LPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQP----------RLLELPREYERLFTYYHERPCL---NCYKVPKESSICLLCGTIVCLKQNCCAEND------CCEAVRHTLSCGGGIGIFLVVTSTYIIVI--RGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSH 2202

HSP 2 Score: 66.2402 bits (160), Expect = 3.374e-10
Identity = 49/179 (27.37%), Postives = 76/179 (42.46%), Query Frame = 1

Query:  220 IIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSI-----FKYFKNFVMRPLCKLSLEKRTEELKVEQEFAS-----KHLSSIKSKELSLVLYNNEFHNF 726
            I+ S  + + CG ++      Y CR C       +CR CF K  HT H++ M  S  GG CDCGD    K    C+ HG + + + D               V  N LA++++I     F+  ++F  R      LE +       +EFA+      ++  I  K ++  L N E + F
Sbjct:  214 IVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDHGINNRVNRDP--------------VPNNLLAVAEAIMPKLLFRLLQHF--REHSDTPLEVQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAF 376

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Ubr3 (gene:FBgn0260970 transcript:FBtr0301748)

HSP 1 Score: 87.8113 bits (216), Expect = 1.183e-16
Identity = 67/245 (27.35%), Postives = 101/245 (41.22%), Query Frame = 1

Query: 4804 LSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLD----------------LIPFSNYSYPSWISNQL-------KLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNH 5469
            L FLR+A  +   L   ++P       EF+ L   L+L                  IP +  + P +   QL         + +L L    + W  P          +L++LP E+  + T   +R C           E S+CL+CG  VCL   CC   D         A  H   C  G  +FL   ++ ++V+  + R       +YLD F E D DLKRG PL+L+++ +  LE  WL+H
Sbjct: 1980 LPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRELVLINQHSLWQQP----------RLLELPREYERLFTYYHERPCL---NCYKVPKESSICLLCGTIVCLKQNCCAEND------CCEAVRHTLSCGGGIGIFLVVTSTYIIVI--RGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSH 2203

HSP 2 Score: 66.2402 bits (160), Expect = 3.375e-10
Identity = 49/179 (27.37%), Postives = 76/179 (42.46%), Query Frame = 1

Query:  220 IIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSI-----FKYFKNFVMRPLCKLSLEKRTEELKVEQEFAS-----KHLSSIKSKELSLVLYNNEFHNF 726
            I+ S  + + CG ++      Y CR C       +CR CF K  HT H++ M  S  GG CDCGD    K    C+ HG + + + D               V  N LA++++I     F+  ++F  R      LE +       +EFA+      ++  I  K ++  L N E + F
Sbjct:  214 IVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDTSVMKAEGFCSDHGINNRVNRDP--------------VPNNLLAVAEAIMPKLLFRLLQHF--REHSDTPLEVQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAF 376

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:ZFIN;Acc:ZDB-GENE-081107-29])

HSP 1 Score: 417.157 bits (1071), Expect = 1.146e-118
Identity = 466/1866 (24.97%), Postives = 787/1866 (42.18%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL-----LIDVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQS-------SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK-----------KDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFN-------ILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYL--INAVC---KAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLS--LKNVNIEN-TDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNV--DGEFIELFRVLKLDLIPFSNYSYPSWISNQLKL-ISDLKLSEA--KTFWNTPLPHVM---------PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S+          +D   ++    +A + ++F     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL + I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q A++Y+ +   +  DDH    S+ SL+ QLFT  + A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + +++ F  F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L      I+V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +I+ +  R+  GVG+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA   +   +   ++  +       F+ Y  +YS  D+++AE + +   ++ G    + PP+        A L+N +       +L   L   + +P+G +W++++L  VL+LIG  L+E+ ++L    E+     F+  +  S       +   I+  LE L +    +   ++I+WI++    IK  +    ++    +S  + E    D E  +     +  KA+ A+ RRE +M++M  MQ+ FINEN EL  +             +  P +CD   V             ++   TCILCQ E+    + + +VL A   RS V++K+      PPH                                NP + D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++    L K   S        W+   S  M    S  +K + + +  +      N         + H TP K   SS   E L +   +   + +K+HP++                        I    +  YTI   +R++++    +   +P R  + L  L    + C    +H    N          F  LL  ++ D              + +    IL+VD   +L SL+    ++   + S          + +    + +  I     VQ+LL+   + V +E  T    ++ ++   L++     N L S+    +R+V   W +     A         +L +LR A    H L     P   +    GE+  L   L L              SN L+L  ++L + E     + + P    +         P     LIDLP +++ +I       C   P++ G  S + +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L  E Y K+++ W  HSI   I     +N   V
Sbjct:   96 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSSQ---------KDPLANLSAEMIARTYNVFSIILKYAVD---MLTWDK-------EDELPEGLEPPARGDMYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALNWLGQTIRYSDALRRILC-----QVGLQRGPEG-ENSSLVDKLMLCDSKMWKGARNVYHQLFMSSLLMDPKYKKLFAIQFARSYQRLQTDFMEDDHERVVSVTSLSVQLFTAPTVARMLITDENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISRPTE--------------------WTDQLREKYLEGFDAFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKSLSALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHALLSKIEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLIMLQAGASMMDPNHFLMIMLSRFELYHIFSSADCRKRYSRENANKDVVQQNNTLIEEMLHLIIMIVGERYTAGVGQ-VEITDEIRREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVALFKKPGVTGRGLYKLRPECA-KMFNLYFHHYSRADQSKAEEAQRKIKRQNGEDSVLPPPVLPRFCPLFASLVNILQCDVLLGILGAVLQWAM-EPSGGHWSESMLQRVLHLIGMGLVEEQQHLISSAEDYNDTNFNFTLKISRPGEAPANTASILALLETLQNAPHLEVHKDMIRWILKTVAYIKTTRECTASAPPSDSSGHSQEETVRDKEKAE-----RKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEDLDPSTSSTLEHSPSSCDSALVCVGPRRWRAGGSDRRQVVTCILCQEEQEIRSDGKAMVLAAFVQRSTVMSKN---RKRPPH--------------------------------NPDKYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLP---LTKTCCSSEQPDLSQWLNITSHQMKALISAHRKSKTSSAEAADETDGVNDCPPPDGFRLDH-TP-KNPYSSTIKEMLTTFGTATYKVGLKVHPNEQDPRVP------------------IMCWGSCAYTIQSIERLLVDEEKPLFGSLPCRQDDCLSSLTRFGSACWTVSSHTTVQNH---------FIRLLAALVPD-------------PRVENTPCILDVDMFHLLVSLVLSHPAVLCLDSSG--------LSADAAQLHFLHLITVAHVVQILLTSLPEEVRMEQETGGAEREEEESVCLLY-----NTLRSLLGRGLREVSSGWHLWRCVKA--------GILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLP-------------SNLLQLYFNNLDIMEPLLHGWCSHPALQALQSSVTLIRFPRESNHLIDLPGDYSALINQASSFTC---PKSGGDKSRVPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSITEEIGHAQEANQTLV 1752

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:ZFIN;Acc:ZDB-GENE-081107-29])

HSP 1 Score: 414.846 bits (1065), Expect = 5.206e-118
Identity = 469/1855 (25.28%), Postives = 782/1855 (42.16%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHH-----------YSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL-----LIDVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQS-------SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK-----------KDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYL--INAVC---KAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLS--LKNVNIEN-TDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNV--DGEFIELFRVLKLDLIPFSNYSYPSWISNQLKL-ISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S+          +D   ++    +A + ++F     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL + I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q       +              Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + +++ F  F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L      I+V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +I+ +  R+  GVG+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA   +   +   ++  +       F+ Y  +YS  D+++AE + +   ++ G    + PP+        A L+N +       +L   L   + +P+G +W++++L  VL+LIG  L+E+ ++L    E+     F+  +  S       +   I+  LE L +    +   ++I+WI++    +KL+K+S       E + T   D E  +     +  KA+ A+ RRE +M++M  MQ+ FINEN EL  +             +  P +CD   V             ++   TCILCQ E+    + + +VL A   RS V++K+      PPH                                NP + D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++                       LSQW+ N  S   K  I+    SK  S   +L+++        SS   E L +   +   + +K+HP++                        I    +  YTI   +R++++    +   +P R  + L  L    + C    +H    N          F  LL  ++ D              + +    IL+VD   +L SL+    ++   + S          + +    + +  I     VQ+LL+   + V +E  T    ++ ++   L++     N L S+    +R+V   W +     A         +L +LR A    H L     P   +    GE+  L   L L              SN L+L  ++L + E       PL H  P     LIDLP +++ +I       C   P++ G  S + +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L  E Y K+++ W  HSI   I     +N   V
Sbjct:   93 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSSQ---------KDPLANLSAEMIARTYNVFSIILKYAVD---MLTWDK-------EDELPEGLEPPARGDMYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALNWLGQTIRYSDALRRILC-----QVGLQRGPEG-ENSSLVDKLMLCDSKMWKGARNVYHQLFMSSLLMDPKYKKLFYIQSHTPLLFLSLFCLSSPPSRFLDYVKDDHDREFSVTDLSVQMFTVPSLARMLITDENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISRPTE--------------------WTDQLREKYLEGFDAFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKSLSALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHALLSKIEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLIMLQAGASMMDPNHFLMIMLSRFELYHIFSSADCRKRYSRENANKDVVQQNNTLIEEMLHLIIMIVGERYTAGVGQ-VEITDEIRREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVALFKKPGVTGRGLYKLRPECA-KMFNLYFHHYSRADQSKAEEAQRKIKRQNGEDSVLPPPVLPRFCPLFASLVNILQCDVLLGILGAVLQWAM-EPSGGHWSESMLQRVLHLIGMGLVEEQQHLISSAEDYNDTNFNFTLKISRPGEAPANTASILALLETLQNAPHLEVHKDMIRWILK----VKLIKSSLPSHLLLECICT-VRDKEKAE-----RKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEDLDPSTSSTLEHSPSSCDSALVCVGPRRWRAGGSDRRQVVTCILCQEEQEIRSDGKAMVLAAFVQRSTVMSKN---RKRPPH--------------------------------NPDKYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLSEQ------------------PDLSQWL-NITSHQMKALISAHRKSKTSSDMFLLIRNPY------SSTIKEMLTTFGTATYKVGLKVHPNEQDPRVP------------------IMCWGSCAYTIQSIERLLVDEEKPLFGSLPCRQDDCLSSLTRFGSACWTVSSHTTVQNH---------FIRLLAALVPD-------------PRVENTPCILDVDMFHLLVSLVLSHPAVLCLDSSG--------LSADAAQLHFLHLITVAHVVQILLTSLPEEVRMEQETGGAEREEEESVCLLY-----NTLRSLLGRGLREVSSGWHLWRCVKA--------GILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLP-------------SNLLQLYFNNLDIME-------PLLHGFPRESNHLIDLPGDYSALINQASSFTC---PKSGGDKSRVPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSITEEIGHAQEANQTLV 1706

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: ubr1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:ZFIN;Acc:ZDB-GENE-091110-2])

HSP 1 Score: 169.474 bits (428), Expect = 1.167e-44
Identity = 106/382 (27.75%), Postives = 177/382 (46.34%), Query Frame = 1

Query:  169 DYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISF 1314
            +YF   E+  +G        S+ S+  CG++FK  E VY CRDCA D TCVLC  CF KS H  H Y+MH SSGGG+CDCGD EAWK    C+ H    +++ ++ E ++    D  +  +   L      F     +    L        +EELK            +K      +LYN+E H+++ VI   +R + C   +A  Y  ++D++GR  A+     +  +  K+ I   S+      L   + H  +++ Q   + +  W  + I      R + C             +  +K +LI  +  +  +++K AR V    I  ++  +T +K+ F ++  ++YK +   +  DDH    S+ +L+ Q+FTV + 
Sbjct:   60 EYFLFGEEPCVGLEKLQRYNSSSSAQQCGRVFKEGETVYSCRDCAIDPTCVLCIECFQKSVHKSHRYKMHASSGGGFCDCGDVEAWKTGPCCSQHDPGTEATMETDECVM----DPGLQERAQML------FHLLLQYTTDMLIWEENNDLSEELK----------PKVKEDSYFCILYNDEHHSYDHVIYTLQRAIACDQNQAQVYTALIDKEGR-RAVKRGTLRTCQQAKDNIRRNSEHIIQKPLRVEVLHTAVMAHQTFALRLGAWFQKIIGYSVGFRDVFCQMALEPA------SDNDKLSLISRLMLHDAKLYKGARKVVHELIFCSLLMDTEYKRQFAMKFTEHYKQLQEDFISDDHQRNISITALSVQIFTVPTL 414

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: LO018474.1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:NCBI gene;Acc:568531])

HSP 1 Score: 109.768 bits (273), Expect = 2.068e-23
Identity = 163/633 (25.75%), Postives = 273/633 (43.13%), Query Frame = 1

Query: 2167 MFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD--QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQS------------SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENS---ELLTEKKDQHPVACDEDHVDSNVHK------------KLD---FTCILCQEKNTEENNRP-IVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNR---CPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGS 3945
            MFD+D+ +LQ+ A  + P  F++  + +F+L     G     S  + VL++     E+ L+ LII +  R+  G+  NVTKED+    ++H LC++ M+HS L+K L  +     +  L  +I KVA+  +   S   ++N KK   L +F+ +  +YS    ++AE + K    +E     + PP+P       + ++N +    +  +L + L   + +   + WT+ ++   L+L+G +LLE+   LE    E+    F     ++            +K+  + +L++L D         +I W ++    +K ++     + SF AM+    + E+VQ   Q + A+A  A +R+  +M++M  MQK FI  N    E + E   Q   A   D    +V K             LD    TCILCQE+   +   P +VL A   RS VL             QS       T+   VD   +F           P ++  G              T   +CGH MH  C   Y + +    +N  R    L   + N    CPLCK +CN  IP+I    +   S +  S        TL +W+    S+ + L+   + W+  GS
Sbjct:    1 MFDKDVIMLQIAASKMDPNHFLMLVLLRFELFDIFNG--NCSSKDQEVLKQWNRLTEEMLYLLIIIVGERYVPGIS-NVTKEDVIMREVIHLLCIEPMAHSTLIKSLPENENH--ETGLETVIAKVANFKKPGVSGHGLYNVKKE-CLKEFNPFFYHYSRPQHSKAEEAQKERRSQESSEKALRPPVPPPFRPAFSSIVNLLCCDIFIHVLRRILQKAV-EDRSNQWTEPMIQRALHLVGQALLEETTQLENSSAEEVTFDFSLKAKKTGSEQGKSLLHFLTKMKSLPSLKVLKD---------MIAWNLQMFEVVKCLREKSSPAASF-AMDHSKAE-ESVQDKEQKRKAEAAKAHRRK--IMAQMSAMQKNFIESNKILYENMPESSSQSDTAASLDSFVMDVDKNRVAVGPQQGVWSLDWETLTCILCQEEQEVQAQAPAMVLTACVQRSTVLT------------QSRGK----TLSPKVDYYPLFM----------PPDLAVG--------------THTGSCGHFMHATCWQKYFEAVQSTTRN--RLHAELIIDLENGEYMCPLCKSLCNTVIPLIP---VEPSSLNYESAQLVGQHLTLMRWIQIMSSRIRGLK---AMWTADGS 565

HSP 2 Score: 96.2857 bits (238), Expect = 2.598e-19
Identity = 104/400 (26.00%), Postives = 163/400 (40.75%), Query Frame = 1

Query: 4360 FDCTNLSFHRAWLDLYKYQIPL-------FILEVDFTFVLGSLLFMRYSLADSNQSD-PNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFS-IRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLK--LSEAKTFW--NTPLPHVM---------PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVIND 5493
              C  +   + + D+    +P+        ILEVDF  +L  L+    SL      D   S  +  +N    + Y+++ I     +QVLL+  +  +    + + +  D        +   E FS + +   R   G    S         G  + +L FLR A    + L  V  P   +V  E  E     +L L+     SY S  SN  +L  D +  ++     W  NT +   +         P    +LIDLP +++ ++       C  S  +       +LCL+CGV +C    CC   ++ +G  +     HA  C  G  LFL  R  ++V++  + R   Y  P YLD +GE+D  L RGNPL L  E Y KL   W  H   CV+ +
Sbjct:  677 MKCNQVVIQKHFADMLAVLVPVPHVENTPSILEVDFFHLLVGLVLSIPSLYQEEAVDLQPSAVSTAYN----HLYLLQLITVGHMLQVLLAAHDCAV----MAVAEEGDEA------QAAAEFFSTVSQHTDRMKSGVLSFS-------VEGVKRGVLPFLRCAALFFNCLTGVPPPDELSVSAELPES----QLPLL----CSYLSLPSNLFQLFQDHRDVMTTLINRWCGNTAISKALKGEMHMIRYPRKRNRLIDLPEDYSVLLNQASHFKCPNS--SDDERKHPTLCLLCGVMLCAQSSCCH--EQLNGEEVGACTGHAAICGAGVGLFLRVRECEIVLMASKTRGSPYPAP-YLDDYGETDPQLGRGNPLHLCPERYRKLLHLWQQH---CVLEE 1039

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: BX248117.1 (pep chromosome:GRCz11:CHR_ALT_CTG13_1_2:3265968:3277581:-1 gene:ENSDARG00000115695.1 transcript:ENSDART00000184770.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX248117.1)

HSP 1 Score: 100.138 bits (248), Expect = 9.400e-22
Identity = 78/264 (29.55%), Postives = 114/264 (43.18%), Query Frame = 1

Query: 4696 NELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNV--DGEFIELFRVLKLDLIPFSNYSYPSWISNQLKL-ISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            N L S+    +R+V   W +     A         +L +LR A    H L     P   +    GE+  L   L L              SN L+L  ++L + +        +    P     LIDLP +++ +I       C   P++ G  S + +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L  E Y K+++ W  HSI
Sbjct:   96 NTLRSLLGRGLREVSSGWHLWLCVKA--------GILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLP-------------SNLLQLYFNNLDIMDCCLCCAGGVLIQFPRESNHLIDLPGDYSALINQASSFTC---PKSGGDKSRVPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSI 332

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: nup62 (nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257978])

HSP 1 Score: 408.297 bits (1048), Expect = 1.089e-115
Identity = 465/1832 (25.38%), Postives = 793/1832 (43.29%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKS--DMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDS-SASDEDLVSCLASRT-ALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIP-------LFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLK----NVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ + + Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A   I +       ++    L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+  K    K ++Q+     E+ LH +I+ +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI++  + IK ++     S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++     + +++  S        W+ T SQ +    +   +   +    S++ +  +I        +  +  S S  ++++   + T  + + +HP++                        I    +  YTI   +RI+ +    +  ++P R  + L+ L                      S F   H  +  C      + +  L++  +P         IL++D   +L SL+    +L   + S     GN +   + + F++V   +    VQ++LS       +  E+TD   +Q                  S+  ++ R  G   K       E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N     V  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct:   92 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYERLQNDYVKDDHDREFSITDLSVQIFTVPSLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGKQI-MFILGSFELS-PPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKDIIQQNNTLIEEMLHLIIMIVGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWILKMVSNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPMLPPPRSLYHRLDFS-DQPDLAEWVSTTSQQLKALCALHAEKSSSAGSDSEMPAQVDIPEGFRPDFQPKNPYSESIREMLTTFGTATYKVGLNVHPNEQDPRVP------------------IMCWGSCAYTIQTIERILADEERPLFGNLPCRQDDCLKSL----------------------SRFAAAHWTV--CPLPVMEKHFSRLFETIVPNEDAENSPCILDIDMFHLLVSLVVSFPALQCQDFS-----GNSLATGDLHLFHLVTMAH---IVQIVLSCSTEENGMEQESTDGEEEQAA---------------MSLYRTICRCSGSTMK-------ELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGERTAVSYPRESNKLIDLPEDYSSLINQASNFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1720

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: nup62 (nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257978])

HSP 1 Score: 398.667 bits (1023), Expect = 1.322e-112
Identity = 463/1831 (25.29%), Postives = 789/1831 (43.09%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQ-----SDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKL----EIAVSWWSKLGSHFNILMKHATPMKTSDS-SASDEDLVSCLASRT-ALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIP-------LFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLK----NVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ + + Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A   I +       ++    L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+     ++K   +   +  +  L+  +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI++  + IK ++     S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP     ML    +    + F +  + L++W+     + K L        S  S++ +  +I        +  +  S S  ++++   + T  + + +HP++                     +  I    +  YTI   +RI+ +    +  ++P R  + L+ L                      S F   H  +  C      + +  L++  +P         IL++D   +L SL+    +L   + S     GN +   + + F++V   +    VQ++LS       +  E+TD   +Q                  S+  ++ R  G   K       E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N     V  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct:   88 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYERLQNDYVKDDHDREFSITDLSVQIFTVPSLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGKQI-MFILGSFELS-PPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKVTSINCVQSMIFFLLSDIGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWILKMVSNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIP-----MLPPPRSLYHRLDFSDQPD-LAEWVSTTSQQLKALCALHAEKSSSDSEMPAQVDIPEGFRPDFQPKNPYSESIREMLTTFGTATYKVGLNVHPNE------------------QDPRVPIMCWGSCAYTIQTIERILADEERPLFGNLPCRQDDCLKSL----------------------SRFAAAHWTV--CPLPVMEKHFSRLFETIVPNEDAENSPCILDIDMFHLLVSLVVSFPALQCQDFS-----GNSLATGDLHLFHLVTMAH---IVQIVLSCSTEENGMEQESTDGEEEQAA---------------MSLYRTICRCSGSTMK-------ELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGERTAVSYPRESNKLIDLPEDYSSLINQASNFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1710

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: nup62 (nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257978])

HSP 1 Score: 396.356 bits (1017), Expect = 8.366e-112
Identity = 463/1831 (25.29%), Postives = 789/1831 (43.09%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQ-----SDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKN---SGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKL-----EIAVSWWSKLGSHFNILMKHATPMKTSDS-SASDEDLVSCLASRT-ALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIP-------LFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLK----NVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ +   +  DDH+   S+ +L+ QLFTV + A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A   I +       ++    L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+     ++K   +   +  +  L+  +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI+ K N  K+ +N   S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP     ML    +    + F +  + L++W+     + K L     E +    S++ +  +I        +  +  S S  ++++   + T  + + +HP++                     +  I    +  YTI   +RI+ +    +  ++P R  + L+ L                      S F   H  +  C      + +  L++  +P         IL++D   +L SL+    +L   + S     GN +   + + F++V   +    VQ++LS       +  E+TD   +Q                  S+  ++ R  G   K       E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N     V  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct:   88 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYQQLQRDFMEDDHDRAVSVAALSVQLFTVPTLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGKQI-MFILGSFELS-PPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKVTSINCVQSMIFFLLSDIGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWIL-KVNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIP-----MLPPPRSLYHRLDFSDQPD-LAEWVSTTSQQLKALCALHAEKSTGSDSEMPAQVDIPEGFRPDFQPKNPYSESIREMLTTFGTATYKVGLNVHPNE------------------QDPRVPIMCWGSCAYTIQTIERILADEERPLFGNLPCRQDDCLKSL----------------------SRFAAAHWTV--CPLPVMEKHFSRLFETIVPNEDAENSPCILDIDMFHLLVSLVVSFPALQCQDFS-----GNSLATGDLHLFHLVTMAH---IVQIVLSCSTEENGMEQESTDGEEEQAA---------------MSLYRTICRCSGSTMK-------ELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGERTAVSYPRESNKLIDLPEDYSSLINQASNFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1709

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: nup62 (nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257978])

HSP 1 Score: 324.709 bits (831), Expect = 4.411e-89
Identity = 339/1255 (27.01%), Postives = 570/1255 (45.42%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALL-------IDVKYRNQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKN---SGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII 3795
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ + + Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A L        +  K+  QL  +E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+  K    K ++Q+     E+ LH +I+ +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI+ K N  K+ +N   S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++
Sbjct:   66 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYERLQNDYVKDDHDREFSITDLSVQIFTVPSLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGLHALLSKSEVAYKFPEQLPFSELSPPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKDIIQQNNTLIEEMLHLIIMIVGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWIL-KVNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPML 1198

HSP 2 Score: 112.464 bits (280), Expect = 5.830e-24
Identity = 82/252 (32.54%), Postives = 118/252 (46.83%), Query Frame = 1

Query: 4750 KISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM-PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            + S  T  E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N     V  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct: 1434 RCSGSTMKELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGERTAVSYPRESNKLIDLPEDYSSLINQASNFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1678

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: nup62 (nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257978])

HSP 1 Score: 313.153 bits (801), Expect = 1.875e-85
Identity = 328/1244 (26.37%), Postives = 561/1244 (45.10%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQ-----SDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII 3795
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ + + Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A   I +       ++    L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+     ++K   +   +  +  L+  +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI++  + IK ++     S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++
Sbjct:   88 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYERLQNDYVKDDHDREFSITDLSVQIFTVPSLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGKQI-MFILGSFELS-PPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKVTSINCVQSMIFFLLSDIGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWILKMVSNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPML 1208

HSP 2 Score: 93.2041 bits (230), Expect = 4.332e-18
Identity = 75/251 (29.88%), Postives = 111/251 (44.22%), Query Frame = 1

Query: 4750 KISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            + S  T  E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N           P+   + +E+ +         C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct: 1466 RCSGSTMKELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGER------TAPRYKCI-SEYRQAYMFSFYCRC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1702

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:MGI Symbol;Acc:MGI:1861099])

HSP 1 Score: 320.857 bits (821), Expect = 6.301e-88
Identity = 346/1282 (26.99%), Postives = 564/1282 (43.99%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGK----QSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE----------KKDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  S     +  + +V+  EDV +    N  AI   +F+Y  +        L+ EK + EL  + E A       KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  +  K  I VR+ S+    L  ++ H  + + QN  +  L WL   I     LR +LC     E          E S+L+  +  N  ++WK AR+V     M+++  +  +KKLF ++ A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ LL   N M  I+K   +        L+H++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++       +     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK    +   K V+Q+     E+ L+ +I+ +  R   GVG+    ++I    I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP         A L+N +       ++   L   +   +G  W++++L  VL+LIG +L E+  +LE  +E     F F   I++          I+  LE L +  S +   ++I+W+++  N IK ++     S   EA    ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  P   D          + V +   F TCILCQ E+     +R +VL A   RS VL+K                 D T   A                  +P + D   M   +S   H       +CGHVMH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++     +L++  N         W   ++Q
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVHLSEDV-IARTYNIFAI---MFRYAVDI-------LTWEKES-ELPEDLEVAE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCDQAKTVI-VRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFALRFAKNYERLQRDYVTDDHDREFSVADLSVQIFTVPSLARMLLTEENLMTVIIKAFMDH-------LKHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLQGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLAVLTQCHGG-FTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIMLVGERFNPGVGQVAATDEI-KREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIESVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFASLVNILQCDVMLYIMGTILQWAVEH-HGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAIKKIRECSSSSPVAEAEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATLDSSPPVSDAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVGSRAMVLAAFVQRSTVLSK-----------------DRTKTIA------------------DPEKYDPLFMHPDLSCGTHT-----GSCGHVMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRAVTQ 1252

HSP 2 Score: 108.612 bits (270), Expect = 7.348e-23
Identity = 78/245 (31.84%), Postives = 112/245 (45.71%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM-PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            +++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K + N     +  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L QE + K+++ W  HSI   I     +N   V
Sbjct: 1511 AIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLPTNLIHLFQENSDIMNSL-IESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQA--ELEGEDVGACTAHTYSCGSGAGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:MGI Symbol;Acc:MGI:1861099])

HSP 1 Score: 315.079 bits (806), Expect = 3.392e-86
Identity = 342/1282 (26.68%), Postives = 561/1282 (43.76%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGK----QSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE----------KKDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  S     +  + +V+  EDV +    N  AI   +F+Y  +        L+ EK + EL  + E A       KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  +  K  I VR+ S+    L  ++ H  + + QN  +  L WL   I     LR +LC     E          E S+L+  +  N  ++WK AR+V     M+++  +  +KKLF ++ A+NY+ +   +  DDH    S+ +L+ Q FT  + A+ LL   N M  I+K   +        L+H++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++       +     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK    +   K V+Q+     E+ L+ +I+ +  R   GVG+    ++I    I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP         A L+N +       ++   L   +   +G  W++++L  VL+LIG +L E+  +LE  +E     F F   I++          I+  LE L +  S +   ++I+W+++  N IK ++     S   EA    ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  P   D          + V +   F TCILCQ E+     +R +VL A   RS VL+K                 D T   A                  +P + D   M   +S   H       +CGHVMH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++     +L++  N         W   ++Q
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVHLSEDV-IARTYNIFAI---MFRYAVDI-------LTWEKES-ELPEDLEVAE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCDQAKTVI-VRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFALRFAKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLLTEENLMTVIIKAFMDH-------LKHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLQGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLAVLTQCHGG-FTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIMLVGERFNPGVGQVAATDEI-KREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIESVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFASLVNILQCDVMLYIMGTILQWAVEH-HGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAIKKIRECSSSSPVAEAEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATLDSSPPVSDAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVGSRAMVLAAFVQRSTVLSK-----------------DRTKTIA------------------DPEKYDPLFMHPDLSCGTHT-----GSCGHVMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRAVTQ 1252

HSP 2 Score: 108.612 bits (270), Expect = 6.869e-23
Identity = 78/245 (31.84%), Postives = 112/245 (45.71%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            +++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K + N     +  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L QE + K+++ W  HSI   I     +N   V
Sbjct: 1511 AIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLPTNLIHLFQENSDIMNSL-IESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQA--ELEGEDVGACTAHTYSCGSGAGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Ubr1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:MGI Symbol;Acc:MGI:1277977])

HSP 1 Score: 301.212 bits (770), Expect = 6.531e-82
Identity = 317/1292 (24.54%), Postives = 549/1292 (42.49%), Query Frame = 1

Query:  247 ICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAK--------LIVSNRQCWERAFEILRQFF-KTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVT---------ETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR---AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPL-FFDACINQSSKVDIIGNLELLCDKISCDQQLE----LIKWIIRKCNEIKLMKNSG----HVSTSFEAMETD--NNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFIN------ENSELLTEKKD-----QHPVACDE-------DHVDSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMS----FQNWMETLSQWMPNFGSKTKKLE 3912
            +CGK+FK+ E  Y CRDCA D TCVLC  CF  S H  H Y+MHTS+GGG+CDCGD EAWK    C    D     A +T+E ++     P++ ++  +A ++ IF     +++        ++   EL++ +          K++    VL+N+E H+++ VI   +R L C    A  +   +D++GR  A+ +      +  K +I   S++ +   L   + H ++++ Q   + +  W+ + +      R + C     E      E   E   LI  +     +++K AR +    I ++ F E  +KKLF ++  + YK +   Y  DDH    S+ +L+ Q+ TV + A++L+E  N +  I + +   L EY                     +D N KF       D   R    + DLK++L S                       IW +     F++ F++F   L+ +Q  + I R +  H+E DP+W+  + +     N + +  +        L+V+ ++C +        F   T+ V           L  +S      +     +S+  PL R +A L + +     ++           + + L++  L+ LV  +Q    MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F+L  + +++L       +  + D+  + Q     E+ L  LI  +  R+  GVG NVT+E++    I H LC++ M HS + + L  +     +  L N+I+KVA      +S   V     +S  L DF+ Y  +YS    ++AE   K   K+E     + PP P +     ++++N +S      +L       +     + WT+ +L M  +++   LLE+ + L+   EE+    F+       S      N+++L +K+    QLE    +I WI++  + +K ++         ++  E ++++   +D E  +     +  KA+AA+  R+ +M++M  +QK FI       +N+  +T K+D     +   A  E             V +K   TCILCQ E+  +  N  +VL A   +S  L +H                        VD          L E  +P  +D           D A  T+  +CGHVMH  C   Y + +    Q                CPLCK +CN  IPII        S +  +++       W++T+   +  +  K  K E
Sbjct:   98 LCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCV---DHEPGRAGTTKESLH----CPLNEEV--IAQARRIFPSVIKYIVEMTIWEEEKELPPELQIRE----------KNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGR-RAVKAGVYATCQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLVE------EPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALSVQMLTVPTLARHLIEEQNVISVITETLLEVLPEY---------------------LDRNNKFNFQGYSQDKLGRVYAVICDLKYILIS--------------------KPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTV---------VQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYY--QDVKC---REEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELTDAFNKTISTK-DQDLIKQYNTLIEEMLQVLIYIVGERYVPGVG-NVTREEVIMREITHLLCIEPMPHSAIARNLPENENN--ETGLENVINKVATFKKPGVSGHGVYELKDES--LKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLSCDVMMYILRTIFERAVDM-ESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLESQKDMITWILQMFDTVKRLREKSCLVVATTSGLECVKSEEITHDKEKAE-----RKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKEDSIMEEESTSAVSEASRIALGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQH--------------------RGKPVDH---------LGETLDPLFMDP----------DLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENAEALAQLLTLARWIQTVLARISGYNIKHAKGE 1257

HSP 2 Score: 91.2781 bits (225), Expect = 1.218e-17
Identity = 73/240 (30.42%), Postives = 103/240 (42.92%), Query Frame = 1

Query: 4810 FLRIAVFMLHELGSVDIPTYF---NVDGEFIELFRVLKLD---LIPFSNY------SYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVIND 5493
            +LR A  + H L  V  P      + +GEF  L   L L     + F  Y          W  +   L+  LK   A   +        P     LI+LP +++ ++       C  S  A        LCL CG  +C    CC+ I   +G  +     HA  C  G  +FL  R  +VV++  +AR   Y  P YLD++GE+D  LKRGNPL L++E Y KL   W  H   C+I +
Sbjct: 1516 YLRCAALLFHYLLGVAPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDP-ALLKSLKQKSAVVRY--------PRKRNSLIELPEDYSCLLNQASHFRCPRS--ADDERKHPVLCLFCGAILCSQNICCQEI--VNGEEVGACVFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAP-YLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQH---CIIEE 1738

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Ubr3 (ubiquitin protein ligase E3 component n-recognin 3 [Source:MGI Symbol;Acc:MGI:1861100])

HSP 1 Score: 87.4261 bits (215), Expect = 2.087e-16
Identity = 64/246 (26.02%), Postives = 110/246 (44.72%), Query Frame = 1

Query: 4804 LSFLRIAVFMLHELGSVDIP-------------------TYFNVDGEFIEL----FRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHS 5472
            L FLR++  + H L   D+P                   T++  D  FI      + V   D+I    +   S+     +    L + E++  W   LPH        L+ LP  +  +      + CS+    +    + ++CLVCG  VCL G CC++       +     +H++ C  G  +FL   N+ V+++    R+ ++   +YLD  GE D DL+RG PL++ +E Y  LE+ W++H+
Sbjct: 1652 LPFLRVSSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTDHPFISASCLDWPVAAFDIITQWCFEITSFTERHAEQGKALLIQESR--WK--LPH--------LLQLPENYNTIFQYYHRKTCSV---CTKVPKDPAVCLVCGTFVCLKGLCCKQQ------SYCECVLHSQNCGAGTGIFLLI-NASVIIIIRGHRFCLW-GSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHT 1874

HSP 2 Score: 61.6178 bits (148), Expect = 1.461e-8
Identity = 28/81 (34.57%), Postives = 41/81 (50.62%), Query Frame = 1

Query:  238 SSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSAD 480
             +++CG ++ A    Y CR C       LC  CF + +HT H++ M  S  GG CDCGD    +    C  H   +KSS++
Sbjct:  116 PAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCRRH--QIKSSSN 194

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Ubr3 (ubiquitin protein ligase E3 component n-recognin 3 [Source:MGI Symbol;Acc:MGI:1861100])

HSP 1 Score: 87.4261 bits (215), Expect = 2.088e-16
Identity = 64/246 (26.02%), Postives = 110/246 (44.72%), Query Frame = 1

Query: 4804 LSFLRIAVFMLHELGSVDIP-------------------TYFNVDGEFIEL----FRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHS 5472
            L FLR++  + H L   D+P                   T++  D  FI      + V   D+I    +   S+     +    L + E++  W   LPH        L+ LP  +  +      + CS+    +    + ++CLVCG  VCL G CC++       +     +H++ C  G  +FL   N+ V+++    R+ ++   +YLD  GE D DL+RG PL++ +E Y  LE+ W++H+
Sbjct: 1655 LPFLRVSSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTDHPFISASCLDWPVAAFDIITQWCFEITSFTERHAEQGKALLIQESR--WK--LPH--------LLQLPENYNTIFQYYHRKTCSV---CTKVPKDPAVCLVCGTFVCLKGLCCKQQ------SYCECVLHSQNCGAGTGIFLLI-NASVIIIIRGHRFCLW-GSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHT 1877

HSP 2 Score: 61.6178 bits (148), Expect = 1.413e-8
Identity = 28/81 (34.57%), Postives = 41/81 (50.62%), Query Frame = 1

Query:  238 SSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSAD 480
             +++CG ++ A    Y CR C       LC  CF + +HT H++ M  S  GG CDCGD    +    C  H   +KSS++
Sbjct:  116 PAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCRRH--QIKSSSN 194

[Close]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q8IWV8|UBR2_HUMAN (E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1)

HSP 1 Score: 328.176 bits (840), Expect = 1.918e-89
Identity = 349/1282 (27.22%), Postives = 573/1282 (44.70%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK----------KDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  +     +  + +V+  EDV +    N  AI+   F+Y           L+ EK + EL  + E         KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  I++ QN  + +L WL   I     LR +LC     E          E S+L+  +  +  ++WK AR+V     M+++  +  +KKLF V+ A+NY+ +   +  DDH    S+ +L+ Q FT  + A+ L+   N M  I+K   +        LRH++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++      S+     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK+       K V+Q+     E+ L+ +I+ +  R   GVG+ V   D     I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP+        A L+N + +     ++   L   +   NG  W++++L  VL+LIG +L E+ ++LE   EE    F F   I++  +       I+  LE L +    +   ++I+WI++  N +K M+ S   S   E     ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  PVA D          + V ++  F TCILCQ E+  +  +R +VL A   RS VL+K+          +S   QD                         P + D   M   +S   H      ++CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++    ++ N   N     +   W+ T+SQ
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVHLSEDV-IARTYNIFAIT---FRYAVEI-------LTWEKES-ELPADLEMVE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCEQAKSVI-VRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMSIIIKTFMDH-------LRHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGG-YTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQ-VNATDEIKREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIEAVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEH-NGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKN----------RSKFIQD-------------------------PEKYDPLFMHPDLSCGTHT-----SSCGHIMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQ 1252

HSP 2 Score: 101.293 bits (251), Expect = 8.571e-20
Identity = 74/245 (30.20%), Postives = 110/245 (44.90%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM-PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
             ++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K +       +  P    KLI+LP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E + K+++ W  HS+   I     +N   V
Sbjct: 1511 GIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSLPNNLICLFQENSEIMNSL-IESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQ--TELEGEDVGACTAHTYSCGSGVGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q6WKZ8|UBR2_MOUSE (E3 ubiquitin-protein ligase UBR2 OS=Mus musculus OX=10090 GN=Ubr2 PE=1 SV=2)

HSP 1 Score: 315.079 bits (806), Expect = 2.373e-85
Identity = 342/1282 (26.68%), Postives = 561/1282 (43.76%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNR----QCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGK----QSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEA----METDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE----------KKDQHPVACDE-----DHVDSNVHKKLDF-TCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPII--KSDMLNKVSNSISSMSFQNWMETLSQ 3873
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H  H Y M TS GGG+CDCGD EAWK   +C  H  S     +  + +V+  EDV +    N  AI   +F+Y  +        L+ EK + EL  + E A       KS     +L+N+E H +EQVI   ++ + CT + A+ +A  VDRDGR  ++   D +  +  K  I VR+ S+    L  ++ H  + + QN  +  L WL   I     LR +LC     E          E S+L+  +  N  ++WK AR+V     M+++  +  +KKLF ++ A+NY+ +   +  DDH    S+ +L+ Q FT  + A+ LL   N M  I+K   +        L+H++ + R    F+ E     + F  F R    + DLK++L S  +                     W D     F++ F  F   L  +Q  D I R +  H+E +P W+    +     + I++       +     + +++   +L Q       D E     T ++  +S   I        +S+  P+ R +A L +     +V Y+      L+      L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ     + P  F++  + +F+L   + T   GK    +   K V+Q+     E+ L+ +I+ +  R   GVG+    ++I    I+H L +K M+HS+L+K L     K  +  + ++I+ VA      L+ + +     K     +F+ Y  ++S  ++++AE + +   ++      + PP         A L+N +       ++   L   +   +G  W++++L  VL+LIG +L E+  +LE  +E     F F   I++          I+  LE L +  S +   ++I+W+++  N IK ++     S   EA    ME  + D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +            D  P   D          + V +   F TCILCQ E+     +R +VL A   RS VL+K                 D T   A                  +P + D   M   +S   H       +CGHVMH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++     +L++  N         W   ++Q
Sbjct:   91 QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVHLSEDV-IARTYNIFAI---MFRYAVDI-------LTWEKES-ELPEDLEVAE------KSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGR-RSVRYGDFQYCDQAKTVI-VRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEG------PDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFALRFAKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLLTEENLMTVIIKAFMDH-------LKHRDAQGR----FQFERYTALQAFK-FRRVQSLILDLKYVLISKPTE--------------------WSDELRQKFLQGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLAVLTQCHGG-FTDGEQPI--TLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRR---EMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIMLVGERFNPGVGQVAATDEI-KREIIHQLSIKPMAHSELVKSLPEDENK--ETGMESVIESVAHFKKPGLTGRGMY--ELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFASLVNILQCDVMLYIMGTILQWAVEH-HGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAIKKIRECSSSSPVAEAEGTIMEESSRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATLDSSPPVSDAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVGSRAMVLAAFVQRSTVLSK-----------------DRTKTIA------------------DPEKYDPLFMHPDLSCGTHT-----GSCGHVMHAHCWQRYFDSVQAKEQR--RQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRAVTQ 1252

HSP 2 Score: 108.612 bits (270), Expect = 4.805e-22
Identity = 78/245 (31.84%), Postives = 112/245 (45.71%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            +++ FL+ +    H L  V  P    V G   F  L   L L       +   S I N L + S  + SE K + N     +  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L QE + K+++ W  HSI   I     +N   V
Sbjct: 1511 AIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLPTNLIHLFQENSDIMNSL-IESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQASNFSC---PKSGGDKSRAPTLCLVCGSLLCSQSYCCQA--ELEGEDVGACTAHTYSCGSGAGIFLRVRECQVLFLAGKTKGCFY-SPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEANQTLV 1748

[Close]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q8IWV7|UBR1_HUMAN (E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1)

HSP 1 Score: 303.138 bits (775), Expect = 1.260e-81
Identity = 315/1269 (24.82%), Postives = 537/1269 (42.32%), Query Frame = 1

Query:  175 FESFEKFIIGRNDKSIIESNVSSS---ICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAK--------LIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVT---------ETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR---AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLE----LIKWIIRKCNEIK-LMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFIN------ENSELLTEKKD------QHPVACDEDHV------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPII 3795
            F   E ++ G +    +E    S    +CG++FK+ E  Y CRDCA D TCVLC  CF  S H  H Y+MHTS+GGG+CDCGD EAWK    C  H      +              P++ ++  +  ++ IF     +V+        ++   EL++ +          K++    VL+N+E H+++ VI   +R L C    A  +   +D++GR  A+ +      +  K +I   S++ +   L   + H  I++ Q   + +  W+ + +      R + C     E      E   E   LI  +     +++K AR +    I ++ F E  +KKLF ++  + YK +   Y  DDH+   S+ +L+ Q+FTV + A++L+E  N +  I + +   L EY                     +D N KF       D   R    + DLK++L S                       IW +     F++ F++F   L+ +Q  + I R +  H+E DP+W+  + +     N + +  +        L+V+ ++C +        F  +    ++   C   +L + S  V E+      +S+  PL R +A L + +     ++           + + L++  L+ LV  +Q    MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F+L  + +++L       +  + D+  + Q     E+ L  LI  +  R+  GVG NVTKE++    I+H LC++ M HS + K L  +     +  L N+I+KVA      +S   V     +S  L DF+ Y  +YS    ++AE   K   K+E     + PP P +     ++++N ++      +L       I   + + WT+ +L M  +++   LLE+ + L+   EE+  + FD     S       N+++L +K+    QLE    +I WI++  + +K L + S  +  +    E+  ND          +  KA+AA+  R+ +M++M  +QK FI       +N+  +  K+D        P   D   +        +V +K   TCILCQ E+  +  N  +VL A   +S  L +H                                          P E+    +  +    D A  T+  +CGHVMH  C   Y + +    Q                CPLCK +CN  IPII
Sbjct:   71 FTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSR-------CPLNEEV--IVQARKIFPSVIKYVVEMTIWEEEKELPPELQIRE----------KNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGR-RAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLRE------EPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEY---------------------LDRNNKFNFQGYSQDKLGRVYAVICDLKYILIS--------------------KPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQ--SC-GHSLETKSYRVSED-----LVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYY--QDVKC---REEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTK-DQDLIKQYNTLIEEMLQVLIYIVGERYVPGVG-NVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENN--ETGLENVINKVATFKKPGVSGHGVYELKDES--LKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAIDT-DSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEE--VTFDFYHKASRLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQH---------------------------------------RGKPIELSGEALDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPII 1211

HSP 2 Score: 90.1225 bits (222), Expect = 2.242e-16
Identity = 53/151 (35.10%), Postives = 76/151 (50.33%), Query Frame = 1

Query: 5041 PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVIND 5493
            P     LI+LP++++ ++       C  S  A        LCL CG  +C    CC+ I   +G  +     HA  C  G  +FL  R  +VV++  +AR   Y  P YLD++GE+D  LKRGNPL L++E Y KL   W  H   C+I +
Sbjct: 1588 PRKRNSLIELPDDYSCLLNQASHFRCPRS--ADDERKHPVLCLFCGAILCSQNICCQEI--VNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAP-YLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQH---CIIEE 1730

[Close]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|O70481|UBR1_MOUSE (E3 ubiquitin-protein ligase UBR1 OS=Mus musculus OX=10090 GN=Ubr1 PE=1 SV=2)

HSP 1 Score: 301.212 bits (770), Expect = 4.568e-81
Identity = 317/1292 (24.54%), Postives = 549/1292 (42.49%), Query Frame = 1

Query:  247 ICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAK--------LIVSNRQCWERAFEILRQFF-KTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVT---------ETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQR---AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA---DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPL-FFDACINQSSKVDIIGNLELLCDKISCDQQLE----LIKWIIRKCNEIKLMKNSG----HVSTSFEAMETD--NNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFIN------ENSELLTEKKD-----QHPVACDE-------DHVDSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMS----FQNWMETLSQWMPNFGSKTKKLE 3912
            +CGK+FK+ E  Y CRDCA D TCVLC  CF  S H  H Y+MHTS+GGG+CDCGD EAWK    C    D     A +T+E ++     P++ ++  +A ++ IF     +++        ++   EL++ +          K++    VL+N+E H+++ VI   +R L C    A  +   +D++GR  A+ +      +  K +I   S++ +   L   + H ++++ Q   + +  W+ + +      R + C     E      E   E   LI  +     +++K AR +    I ++ F E  +KKLF ++  + YK +   Y  DDH    S+ +L+ Q+ TV + A++L+E  N +  I + +   L EY                     +D N KF       D   R    + DLK++L S                       IW +     F++ F++F   L+ +Q  + I R +  H+E DP+W+  + +     N + +  +        L+V+ ++C +        F   T+ V           L  +S      +     +S+  PL R +A L + +     ++           + + L++  L+ LV  +Q    MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F+L  + +++L       +  + D+  + Q     E+ L  LI  +  R+  GVG NVT+E++    I H LC++ M HS + + L  +     +  L N+I+KVA      +S   V     +S  L DF+ Y  +YS    ++AE   K   K+E     + PP P +     ++++N +S      +L       +     + WT+ +L M  +++   LLE+ + L+   EE+    F+       S      N+++L +K+    QLE    +I WI++  + +K ++         ++  E ++++   +D E  +     +  KA+AA+  R+ +M++M  +QK FI       +N+  +T K+D     +   A  E             V +K   TCILCQ E+  +  N  +VL A   +S  L +H                        VD          L E  +P  +D           D A  T+  +CGHVMH  C   Y + +    Q                CPLCK +CN  IPII        S +  +++       W++T+   +  +  K  K E
Sbjct:   98 LCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCV---DHEPGRAGTTKESLH----CPLNEEV--IAQARRIFPSVIKYIVEMTIWEEEKELPPELQIRE----------KNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGR-RAVKAGVYATCQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLVE------EPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALSVQMLTVPTLARHLIEEQNVISVITETLLEVLPEY---------------------LDRNNKFNFQGYSQDKLGRVYAVICDLKYILIS--------------------KPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTV---------VQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYY--QDVKC---REEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELTDAFNKTISTK-DQDLIKQYNTLIEEMLQVLIYIVGERYVPGVG-NVTREEVIMREITHLLCIEPMPHSAIARNLPENENN--ETGLENVINKVATFKKPGVSGHGVYELKDES--LKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLSCDVMMYILRTIFERAVDM-ESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLESQKDMITWILQMFDTVKRLREKSCLVVATTSGLECVKSEEITHDKEKAE-----RKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKEDSIMEEESTSAVSEASRIALGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQH--------------------RGKPVDH---------LGETLDPLFMDP----------DLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENAEALAQLLTLARWIQTVLARISGYNIKHAKGE 1257

HSP 2 Score: 91.2781 bits (225), Expect = 8.521e-17
Identity = 73/240 (30.42%), Postives = 103/240 (42.92%), Query Frame = 1

Query: 4810 FLRIAVFMLHELGSVDIPTYF---NVDGEFIELFRVLKLD---LIPFSNY------SYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVIND 5493
            +LR A  + H L  V  P      + +GEF  L   L L     + F  Y          W  +   L+  LK   A   +        P     LI+LP +++ ++       C  S  A        LCL CG  +C    CC+ I   +G  +     HA  C  G  +FL  R  +VV++  +AR   Y  P YLD++GE+D  LKRGNPL L++E Y KL   W  H   C+I +
Sbjct: 1516 YLRCAALLFHYLLGVAPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDP-ALLKSLKQKSAVVRY--------PRKRNSLIELPEDYSCLLNQASHFRCPRS--ADDERKHPVLCLFCGAILCSQNICCQEI--VNGEEVGACVFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAP-YLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQH---CIIEE 1738

[Close]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q9VX91|UBR1_DROME (E3 ubiquitin-protein ligase UBR1 OS=Drosophila melanogaster OX=7227 GN=Ubr1 PE=2 SV=2)

HSP 1 Score: 222.631 bits (566), Expect = 7.685e-57
Identity = 290/1259 (23.03%), Postives = 536/1259 (42.57%), Query Frame = 1

Query:  190 KFIIGRNDKSIIE----SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVD-VKINFLAISKSIFKYFKNFVMRPLCKLS-LEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQ---KDIESKKNEI----SVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPD----NAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEI-LRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRNQLNVTETDCL---------LDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQ------IKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYL-----TGIVGKQSDKKAVLQRA--EDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEI--KLMKNSGHVSTSFEAMETDNN-DLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSY-----MKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKS 3801
            +F++G N  S +E       ++++CGK+FK  EP Y CR+C  D TCVLC  CF +S H  H Y+M TS GGG CDCGD+EAWK   +C LH  + K+  +S       L D  ++ V+I F AI      Y +   + P   L  L+   E  +V+              +   VLYN+E H F+QVI    +  +C  + AM     +DR+GR +    T +   K   S +N++    S+ S ++    L   + H   ++ Q   + +L W  EF+ ++         YLF +   ++ +   +++  I+ I E  +++WK+AR      +++ +  E   K +   + ++ Y  I+  +  DDH+   S++SL+ QLFTV S A +L+      D ++   Y+  IE       + I N+  LHF K    +      F+R    L DL++LL                        ++ PD    +  + F++  +     L+++Q  +++ R    H++++P W+    +       I+        + +   + +++ +R       +    K  Q   +  +  + +  +   + +S+  PL RF A + +     D+ Y      TET+ L         ++  L      +Q    +W RNG   Y L  Q      ++C     EM DRD+  LQ+ A  +    F++  +++F+ + +L     + + G + +   + + +  ++FL  LI+ +  R   GV   VT+ED     I+  LC+K  SHS+L + L              +I+ VA   + + +        K  +L +F+ Y  +Y+ +D+++AE   +   K +   +   PP+   LT     + N +  P +  + +  +   +      ++T++ L  VL+L+G ++ E+       L E  P  F +   +S +  I+  LE L      +   + + W I +  ++  K   + G    S     T     L   +   + +  +A  A +RR  +M++M   QK FI+ N+E+  + +       +E   +S     +D+  I  +E+                    +A    ++ L P  +  +  D T       +N   S        S   +  R  + +  ++ +      I+ CGHVMHY C   Y      KE+ +  +N  R        +  +CP C+ + N  IP+ ++
Sbjct:   85 EFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESK-----ILTDAVLERVEICFGAILAFCVSYLE---IEPNASLQCLDGNVEGGQVD------------GAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEFLVRH---------YLFRKTFSELVQRK-QETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHVAIE-------KFIRNK-TLHFSKNIASLTF----FKRANYILYDLRYLL------------------------SLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYDGL--QTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNG---YTLLHQLYFYRNVRCRV---EMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSM-VTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNA-YSRSFTESHLQKVLHLLGYAIQEE-------LSEHYP--FLSFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTE-------NETRKESASTGPMDWEDIPPEEEQ-----------------GAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSR-VIFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPHRN--RAALAQAANVEFQCPYCRTLSNAIIPVTET 1231

HSP 2 Score: 86.2705 bits (212), Expect = 3.388e-15
Identity = 48/142 (33.80%), Postives = 76/142 (53.52%), Query Frame = 1

Query: 5053 PKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQ-IYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            P+L  L ++F+++I    D  C  + +       M  CL+CG+ +C   YCC+   E    ++     HA  C     +FL  R+ +VV   Y  R +  ++ P YLD++GE+D+ L+RGNPL L+Q AY K+   WL H +
Sbjct: 1668 PRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTM--CLICGLILCGQSYCCQ--PELGKVSVGACTHHAHACGAEVGIFLRIRDCQVV---YLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGL 1802

[Close]

BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A4W3H6V2 (E3 ubiquitin-protein ligase OS=Callorhinchus milii OX=7868 PE=3 SV=1)

HSP 1 Score: 433.335 bits (1113), Expect = 6.082e-121
Identity = 485/1855 (26.15%), Postives = 801/1855 (43.18%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ----------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGK----QSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKV-----------DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVS--TSFEAMETDN--NDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE-----------KKDQHPVACDEDHVDSN------VHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLL--SLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIP----------TYFNVDGEFIELFRVLKLDLIPF-SNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N +S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +   + +  E+ + +L +  +    N  AI+   FKY  + +           + +EL +  E   K  +         +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K  I VR+ S+    L  ++ H  +++ Q+  I +L WL   I     LR +LC     +  +Q G    E S+L+  +     ++WK ARN+     M+++  +  +KKLF V+ A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   + L      +R ++   R    F+ E     + F  F R    + DLK++L S  +                     W D   + F++ F+ F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       ++  + K  IV L+   CQ          T ++  +S   ++       +S+  P+ R  A L +     +V Y+      L+      L++  L+ +V C+Q    MW RNG   + L  QI      KC     EM+D+DL +LQ  A  + P  F++  + +F+L   + T   GK    +   K VLQ+     E+ LH +++ +  R+  GVG+ V+ ED     I+H LC++ M+HS+L+K L     K  +  +  +I+ VA      L+ + +     +S    +F+ +  +YS  D+++AE + +   K+ G    + PP+        A L+N + +  +  +L   L+  + +PN   WT+++L  VL+LIG +LLE+ + LE   ++      D   N +SKV            I+  LE L +    +   ++IKWI++    IK M+   + S    +E   T+    D +  +     +  KA+ A+ RRE +M++M  MQK FI+EN EL  +            +D  P   D               KK   TCILCQ E+  + NN+ +VL A   RS V++K                            N M +         +P   D   M       D A  T   +CGH+MH  C  SY   +   +Q   R + +     Y+       CPLC+C+ N  IP++ S       N +  ++F   +  LSQW          L+  +   S L  H     +   P K   S +  E L +   +   + +K+HP++                     +  I    +  YTI   +R++ +    +   +P R  + L+ L      AH+  ++   V +    F  LL  ++ D              K + P  IL+VD   +L SL+    +L   + +     G  +   + + F++V   +    VQ+LL  S +  N+E   V      D D  +      N+L     S +  +   W +     A +          +LR +  + H L  V +P          +Y ++    + LF+     + P    Y Y  W   ++KL S+                       KLIDLP++++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y KL++ W  HSI   I     +N   V
Sbjct:   66 KANKTSHLCGRVFKIGEPTYSCRDCAVDPTCVLCMECFLASVHREHRYRMTTSGGGGFCDCGDTEAWKQGPYCQKHEPTALEAME--EDPLAHLSEDMIGRTYNIFAIA---FKYAVDILTW--------VKEDELPLGLELPEKEDAYF------CMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-RSVRYGDFQFCEQAKTVI-VRNTSRQTKPLKVQVMHSSVVAHQSFGIKLLVWLSHVIGYSGGLRRILC-----QVGLQQGPNE-ENSSLVDKLMLCDSKLWKGARNIYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQTEYVNDDHDREFSVTDLSVQIFTVPSLARMLITDENLMTTIIQTFMDHL------MRQRDSHVR----FQFERYTAIQAFK-FRRVQSLIGDLKYVLVSKPTE--------------------WTDRLREKFLEGFEVFLELLKRMQGMDPVTRQVGQHIEMEPEWEAAFTLQMKLTHTISMMQEWCASDEKV------LIEAYRKCLIVLLQ---CQNGLSDGEQPITLSMCGHSLDTVQYRVSQHQVSIHMPVSRLFAGLHVLLSKTEVAYKFPELLPLSELSPPMLIEHPLRCMVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMYDKDLVMLQAGASMMDPNHFLMIILCRFELYQIFNTPDYGKRFSAEHTNKDVLQQNNTLIEEMLHLIMMIVGERYIAGVGQ-VSTEDEIKREIIHQLCIRPMAHSELVKALPEDENK--ETGMERVIESVASFKKPGLTGRGLYELKPES--AKEFNLFFYHYSRADQSKAEEAQRKLRKQNGEDTALPPPVFPPFCPLFASLVNILQSDVFLYILGTVLHWAV-EPNEHAWTESMLQRVLHLIGMALLEEKQQLESASDDS-----DFTFNFTSKVSRPGDAPENMPSILAMLETLQNAPHLEVHKDMIKWILKLFGVIKKMRERSNSSPVVEYEGYSTEECLRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQKHFIDENRELFQQTLEELEASSSTAQDNSPTVPDTALTALGPKQTRVFEKKQVVTCILCQEEQEIKMNNKAMVLAAFVQRSTVMSK----------------------------NRMRTI-------QDPENYDPLFMHP-----DLACGTHTGSCGHIMHAHCWQSYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLPSS--RSPFNRLDYLAFSE-VPILSQW----------LKCVLQQISVLKKH----QEKTDPGKNPYSDSIKEMLTTFATATYKVGLKVHPNE------------------QDPRVPIMCWGSCAYTIQAIERLLADEEKPLFGHLPCRQDDCLKALTR-FAAAHRTVSSLPVVEK---HFARLLAVLVPD-------------EKAETPPSILDVDMFHLLVSLVLAFPALHCHDFT-----GVSLAVGDFHLFHLVTMAH---IVQILLTSSTEENNMEQESV------DGDEEISVLALYNQLRQHSGSALNVISSGWHLWRCVKAGIK--------PYLRCSALLFHYLNGVPVPLGADDFELLCSYLSLPANLMSLFQSDSNIIDPLIQRYFYSRW---EIKLESN-----------------------KLIDLPDDYSCLINRA---SCFTCPKSGGDKSRAPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTYNCGCGVGIFLRVRESQVLFLAGKTKGCFY-PPPYLDDYGETDQGLRRGNPLHLCKERYRKLQKLWQQHSITEEIGHAQEANQTLV 1683

[Close]

BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A4W3H8E2 (E3 ubiquitin-protein ligase OS=Callorhinchus milii OX=7868 PE=3 SV=1)

HSP 1 Score: 429.098 bits (1102), Expect = 2.228e-119
Identity = 488/1847 (26.42%), Postives = 801/1847 (43.37%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ----------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYRN----QLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGK----QSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKV-----------DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVS--TSFEAMETDN--NDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE-----------KKDQHPVACDEDHVDSN------VHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLL--SLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N +S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +   + +  E+ + +L +  +    N  AI+   FKY  + +           + +EL +  E   K  +         +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K  I VR+ S+    L  ++ H  +++ Q+  I +L WL   I     LR +LC     +  +Q G    E S+L+  +     ++WK ARN+     M+++  +  +KKLF V+ A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   + L      +R ++   R    F+ E     + F  F R    + DLK++L S  +                     W D   + F++ F+ F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       ++  + K  IV L+   CQ          T ++  +S   ++       +S+  P+ R  A L +     +V Y+      L+      L++  L+ +V C+Q    MW RNG   + L  QI      KC     EM+D+DL +LQ  A  + P  F++  + +F+L   + T   GK    +   K VLQ+     E+ LH +++ +  R+  GVG+ V+ ED     I+H LC++ M+HS+L+K L     K  +  +  +I+ VA      L+ + +     +S    +F+ +  +YS  D+++AE + +   K+ G    + PP+        A L+N + +  +  +L   L+  + +PN   WT+++L  VL+LIG +LLE+ + LE   ++      D   N +SKV            I+  LE L +    +   ++IKWI++    IK M+   + S    +E   T+    D +  +     +  KA+ A+ RRE +M++M  MQK FI+EN EL  +            +D  P   D               KK   TCILCQ E+  + NN+ +VL A   RS V++K                            N M +         +P   D   M       D A  T   +CGH+MH  C  SY   +   +Q   R + +     Y+       CPLC+C+ N  IP++ S      S S  + +F   +  LSQW          L+  +   S L  H     +   P K   S +  E L +   +   + +K+HP++                     +  I    +  YTI   +R++ +    +   +P R  + L+ L      AH+  ++   V +    F  LL  ++ D              K + P  IL+VD   +L SL+    +L   + +     G  +   + + F++V   +    VQ+LL  S +  N+E   V      D D  +      N+L     S +  +   W +     A +          +LR +  + H L  V +P      G  +F  L   L L     S +   S I + L +     + E + F       +  P    KLIDLP++++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y KL++ W  HSI   I     +N   V
Sbjct:   75 KANKTSHLCGRVFKIGEPTYSCRDCAVDPTCVLCMECFLASVHREHRYRMTTSGGGGFCDCGDTEAWKQGPYCQKHEPTALEAME--EDPLAHLSEDMIGRTYNIFAIA---FKYAVDILTW--------VKEDELPLGLELPEKEDAYF------CMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-RSVRYGDFQFCEQAKTVI-VRNTSRQTKPLKVQVMHSSVVAHQSFGIKLLVWLSHVIGYSGGLRRILC-----QVGLQQGPNE-ENSSLVDKLMLCDSKLWKGARNIYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQTEYVNDDHDREFSVTDLSVQIFTVPSLARMLITDENLMTTIIQTFMDHL------MRQRDSHVR----FQFERYTAIQAFK-FRRVQSLIGDLKYVLVSKPTE--------------------WTDRLREKFLEGFEVFLELLKRMQGMDPVTRQVGQHIEMEPEWEAAFTLQMKLTHTISMMQEWCASDEKV------LIEAYRKCLIVLLQ---CQNGLSDGEQPITLSMCGHSLDTVQYRVSQHQVSIHMPVSRLFAGLHVLLSKTEVAYKFPELLPLSELSPPMLIEHPLRCMVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMYDKDLVMLQAGASMMDPNHFLMIILCRFELYQIFNTPDYGKRFSAEHTNKDVLQQNNTLIEEMLHLIMMIVGERYIAGVGQ-VSTEDEIKREIIHQLCIRPMAHSELVKALPEDENK--ETGMERVIESVASFKKPGLTGRGLYELKPES--AKEFNLFFYHYSRADQSKAEEAQRKLRKQNGEDTALPPPVFPPFCPLFASLVNILQSDVFLYILGTVLHWAV-EPNEHAWTESMLQRVLHLIGMALLEEKQQLESASDDS-----DFTFNFTSKVSRPGDAPENMPSILAMLETLQNAPHLEVHKDMIKWILKLFGVIKKMRERSNSSPVVEYEGYSTEECLRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQKHFIDENRELFQQTLEELEASSSTAQDNSPTVPDTALTALGPKQTRVFEKKQVVTCILCQEEQEIKMNNKAMVLAAFVQRSTVMSK----------------------------NRMRTI-------QDPENYDPLFMHP-----DLACGTHTGSCGHIMHAHCWQSYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLPS------SRSPFNRAFSE-VPILSQW----------LKCVLQQISVLKKH----QEKTDPGKNPYSDSIKEMLTTFATATYKVGLKVHPNE------------------QDPRVPIMCWGSCAYTIQAIERLLADEEKPLFGHLPCRQDDCLKALTR-FAAAHRTVSSLPVVEK---HFARLLAVLVPD-------------EKAETPPSILDVDMFHLLVSLVLAFPALHCHDFT-----GVSLAVGDFHLFHLVTMAH---IVQILLTSSTEENNMEQESV------DGDEEISVLALYNQLRQHSGSALNVISSGWHLWRCVKAGIK--------PYLRCSALLFHYLNGVPVPVELQELGADDFELLCSYLSLPANLMSLFQSDSNIIDPL-IQRWCGVVEVQKFVKGERAAISYPRESNKLIDLPDDYSCLINRA---SCFTCPKSGGDKSRAPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTYNCGCGVGIFLRVRESQVLFLAGKTKGCFY-PPPYLDDYGETDQGLRRGNPLHLCKERYRKLQKLWQQHSITEEIGHAQEANQTLV 1705

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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: F1Q745 (E3 ubiquitin-protein ligase (Fragment) OS=Danio rerio OX=7955 GN=ubr2 PE=1 SV=2)

HSP 1 Score: 417.157 bits (1071), Expect = 2.564e-115
Identity = 466/1866 (24.97%), Postives = 787/1866 (42.18%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL-----LIDVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQS-------SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK-----------KDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFN-------ILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYL--INAVC---KAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLS--LKNVNIEN-TDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNV--DGEFIELFRVLKLDLIPFSNYSYPSWISNQLKL-ISDLKLSEA--KTFWNTPLPHVM---------PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S+          +D   ++    +A + ++F     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL + I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q A++Y+ +   +  DDH    S+ SL+ QLFT  + A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + +++ F  F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L      I+V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +I+ +  R+  GVG+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA   +   +   ++  +       F+ Y  +YS  D+++AE + +   ++ G    + PP+        A L+N +       +L   L   + +P+G +W++++L  VL+LIG  L+E+ ++L    E+     F+  +  S       +   I+  LE L +    +   ++I+WI++    IK  +    ++    +S  + E    D E  +     +  KA+ A+ RRE +M++M  MQ+ FINEN EL  +             +  P +CD   V             ++   TCILCQ E+    + + +VL A   RS V++K+      PPH                                NP + D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++    L K   S        W+   S  M    S  +K + + +  +      N         + H TP K   SS   E L +   +   + +K+HP++                        I    +  YTI   +R++++    +   +P R  + L  L    + C    +H    N          F  LL  ++ D              + +    IL+VD   +L SL+    ++   + S          + +    + +  I     VQ+LL+   + V +E  T    ++ ++   L++     N L S+    +R+V   W +     A         +L +LR A    H L     P   +    GE+  L   L L              SN L+L  ++L + E     + + P    +         P     LIDLP +++ +I       C   P++ G  S + +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L  E Y K+++ W  HSI   I     +N   V
Sbjct:   96 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSSQ---------KDPLANLSAEMIARTYNVFSIILKYAVD---MLTWDK-------EDELPEGLEPPARGDMYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALNWLGQTIRYSDALRRILC-----QVGLQRGPEG-ENSSLVDKLMLCDSKMWKGARNVYHQLFMSSLLMDPKYKKLFAIQFARSYQRLQTDFMEDDHERVVSVTSLSVQLFTAPTVARMLITDENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISRPTE--------------------WTDQLREKYLEGFDAFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKSLSALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHALLSKIEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLIMLQAGASMMDPNHFLMIMLSRFELYHIFSSADCRKRYSRENANKDVVQQNNTLIEEMLHLIIMIVGERYTAGVGQ-VEITDEIRREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVALFKKPGVTGRGLYKLRPECA-KMFNLYFHHYSRADQSKAEEAQRKIKRQNGEDSVLPPPVLPRFCPLFASLVNILQCDVLLGILGAVLQWAM-EPSGGHWSESMLQRVLHLIGMGLVEEQQHLISSAEDYNDTNFNFTLKISRPGEAPANTASILALLETLQNAPHLEVHKDMIRWILKTVAYIKTTRECTASAPPSDSSGHSQEETVRDKEKAE-----RKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEDLDPSTSSTLEHSPSSCDSALVCVGPRRWRAGGSDRRQVVTCILCQEEQEIRSDGKAMVLAAFVQRSTVMSKN---RKRPPH--------------------------------NPDKYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLP---LTKTCCSSEQPDLSQWLNITSHQMKALISAHRKSKTSSAEAADETDGVNDCPPPDGFRLDH-TP-KNPYSSTIKEMLTTFGTATYKVGLKVHPNEQDPRVP------------------IMCWGSCAYTIQSIERLLVDEEKPLFGSLPCRQDDCLSSLTRFGSACWTVSSHTTVQNH---------FIRLLAALVPD-------------PRVENTPCILDVDMFHLLVSLVLSHPAVLCLDSSG--------LSADAAQLHFLHLITVAHVVQILLTSLPEEVRMEQETGGAEREEEESVCLLY-----NTLRSLLGRGLREVSSGWHLWRCVKA--------GILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLP-------------SNLLQLYFNNLDIMEPLLHGWCSHPALQALQSSVTLIRFPRESNHLIDLPGDYSALINQASSFTC---PKSGGDKSRVPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSITEEIGHAQEANQTLV 1752

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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: B3DM65 (E3 ubiquitin-protein ligase (Fragment) OS=Xenopus tropicalis OX=8364 GN=ubr2 PE=2 SV=1)

HSP 1 Score: 416.387 bits (1069), Expect = 4.028e-115
Identity = 469/1841 (25.48%), Postives = 797/1841 (43.29%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFE---ILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL-------LIDVKYRNQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLG-YLTGIVGKQSDK----KAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVAD---QTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQSSKV-----DIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMK----NSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD-------------------FTCILCQEKNT-EENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKS--DMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDS-SASDEDLVSCLASRT-ALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIP-------LFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLK----NVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFY------KSLLSFLRIAVFMLHELGSVDIPTYFNVDG--EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHV-MPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            ++N  S +CG++FK  EP Y CRDCA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  +L  S   TE+ + +L +  +    N  AI   +F+Y  +        L+ EK       E E         K      +L+N+E H +EQVI   ++ + C+ + A+S+A  VDRDGR  ++ + D +  E  K+ I VR+ S+    L  ++ H  I++ Q   + ++ WL + I     LR +LC     E          E S+L+  +     ++WK ARN      M+++  +  +KKLF ++ A+NY+ + + Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  ++K   +        LR ++I+ R    F+ E     + F  F R    + DLK++L  ++  +                   W D     F++ F+ F   L  +Q  D I R +  H+E +P W+    +     + I++       +      A++   I+     +   D E     T ++  +S   I        +S+  P+ R +A L        +  K+  QL  +E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D+ +LQ  A  + P  F++  + +F+L   + T   GK+  K    K ++Q+     E+ LH +I+ +  R   GVG+ V+  D+    I+H L +K M+HS+L+K L     K  +  +  +I+ +A      L+ + +     K     DF+ +  ++S  ++++AE + +   ++ G    + PP+        A L+N + +     ++   L   + +PNG  W++++L  VL+LIG +L E+ ++L+   E+    F F   I++  +V      I+  LE L +    +   ++I+WI++  + IK ++     S  V T    +E +  D +  +     +  KA+ A+ RRE +M++M  MQ+ FI+EN EL  +  D+   +    + D + H  +D                    TCILCQE+     +N+ +VL A   RS V +K             + S+ +T                      +P + D   M       D A  T   +CGH+MH  C   Y   +   +Q   R + +     Y+       CPLC+C+ N  IP++     + +++  S        W+ T SQ +    +   +   +    S++ +  +I        +  +  S S  ++++   + T  + + +HP++                        I    +  YTI   +RI+ +    +  ++P R  + L+ L                      S F   H  +  C      + +  L++  +P         IL++D   +L SL+    +L   + S     GN +   + + F++V   +    VQ++LS       +  E+TD   +Q                  S+  ++ R  G   K       E++ G++       S+L +LR A    H L  V  P+ F V G  +F  L   L L       +   S +   L +    K +E K F N     V  P    KLIDLP +++ +I    +  C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V+ L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI
Sbjct:   78 QANKPSQLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHREHRYRMTTSGGGGFCDCGDAEAWKGGPYCQKH--ALNISESETEDPLIHLSEDMIARAYNMFAI---MFRYAVDI-------LTWEK-------ENELPDGLECVKKDDTYYCMLFNDEVHTYEQVIYTLQKAVSCSQKEAISFATTVDRDGR-RSVRNGDFQSCEQAKSVI-VRNTSRQTKPLKVQVMHSAIVAHQTFGLKLISWLGQVIGSSGGLRRILCQVGLQEG------PEGENSSLVDRLMLCDSKLWKGARNCYHQLFMSSLLMDLKYKKLFAIRFAKNYERLQNDYVKDDHDREFSITDLSVQIFTVPSLARMLITEENMMATVIKTFMDH-------LRTRDIQGR----FQFERYTALQAFK-FRRVQSLIMDLKYVL--ISKPFE------------------WTDGLRCKFLEGFEAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQDWCSCDEHVLIEAYKKCLIVLMQCHSGFTDGEQPI--TLSISGHSVETIRYCVSQEKVSIHLPVSRLLAGLHALLSKSEVAYKFPEQLPFSELSPPMLIEHPLRSLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRK---EMFDKDIVMLQAGASMMDPNHFLMIVLSRFELYQIFSTPDYGKRFRKEHTNKDIIQQNNTLIEEMLHLIIMIVGERFCPGVGQ-VSGTDVIKREIIHQLSIKPMAHSELVKALPEDENK--ETGMETVIETIASFKKPGLTGRGLY--ELKPECTKDFNLFYFHFSRAEQSKAEEAQRKLKRQIGEDTALPPPVLPPFCPLFASLINILQSDVMLCIMGTVLQWAV-EPNGYAWSESMLQRVLHLIGMALQEEHQHLQNISEDNIVTFNFTEKISRPGEVPNASPSILAMLETLQNAAHLEVHKDMIRWILKMVSNIKKIRENPSTSPVVETEGSVLEENTRDKDKAE-----RKRKAEIARLRREKIMAQMSEMQRHFIDENRELFQQTTDELNASTSTAY-DHSCHAMMDTKLVALGPHQTRISEPRQLVTCILCQEEQAFTVDNKAMVLAAFIQRSTVFSK-------------NRSRVIT----------------------DPEKYDPLCMHP-----DLACGTHTGSCGHIMHAHCWQRYFDAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPMLPPPRSLYHRLDFS-DQPDLAEWVSTTSQQLKALCALHAEKSSSAGSDSEMPAQVDIPEGFRPDFQPKNPYSESIREMLTTFGTATYKVGLNVHPNEQDPRV------------------PIMCWGSCAYTIQTIERILADEERPLFGNLPCRQDDCLKSL----------------------SRFAAAHWTV--CPLPVMEKHFSRLFETIVPNEDAENSPCILDIDMFHLLVSLVVSFPALQCQDFS-----GNSLATGDLHLFHLVTMAH---IVQIVLSCSTEENGMEQESTDGEEEQAA---------------MSLYRTICRCSGSTMK-------ELSSGWHLCRAIKTSILPYLRCAALFFHYLNGVPAPSEFLVSGMSQFDCLCSYLSLPTNLVCLFQENSKVMETL-INRWCKHAEVKRFLNGERTAVSYPRESNKLIDLPEDYSSLINQASNFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELDGDDVGACTAHTYTCGSGMGIFLRVRECQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCKERYKKIQKLWQQHSI 1717

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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: B7ZDA3 (E3 ubiquitin-protein ligase OS=Danio rerio OX=7955 GN=ubr2 PE=1 SV=3)

HSP 1 Score: 414.846 bits (1065), Expect = 1.165e-114
Identity = 469/1855 (25.28%), Postives = 782/1855 (42.16%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHH-----------YSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL-----LIDVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQS-------SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEK-----------KDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYL--INAVC---KAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLS--LKNVNIEN-TDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNV--DGEFIELFRVLKLDLIPFSNYSYPSWISNQLKL-ISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S+          +D   ++    +A + ++F     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL + I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q       +              Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + +++ F  F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L      I+V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +I+ +  R+  GVG+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA   +   +   ++  +       F+ Y  +YS  D+++AE + +   ++ G    + PP+        A L+N +       +L   L   + +P+G +W++++L  VL+LIG  L+E+ ++L    E+     F+  +  S       +   I+  LE L +    +   ++I+WI++    +KL+K+S       E + T   D E  +     +  KA+ A+ RRE +M++M  MQ+ FINEN EL  +             +  P +CD   V             ++   TCILCQ E+    + + +VL A   RS V++K+      PPH                                NP + D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++                       LSQW+ N  S   K  I+    SK  S   +L+++        SS   E L +   +   + +K+HP++                        I    +  YTI   +R++++    +   +P R  + L  L    + C    +H    N          F  LL  ++ D              + +    IL+VD   +L SL+    ++   + S          + +    + +  I     VQ+LL+   + V +E  T    ++ ++   L++     N L S+    +R+V   W +     A         +L +LR A    H L     P   +    GE+  L   L L              SN L+L  ++L + E       PL H  P     LIDLP +++ +I       C   P++ G  S + +LCLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R S+V+ L  + +   Y  P YLD +GE+D  L+RGNPL L  E Y K+++ W  HSI   I     +N   V
Sbjct:   93 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSSQ---------KDPLANLSAEMIARTYNVFSIILKYAVD---MLTWDK-------EDELPEGLEPPARGDMYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALNWLGQTIRYSDALRRILC-----QVGLQRGPEG-ENSSLVDKLMLCDSKMWKGARNVYHQLFMSSLLMDPKYKKLFYIQSHTPLLFLSLFCLSSPPSRFLDYVKDDHDREFSVTDLSVQMFTVPSLARMLITDENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISRPTE--------------------WTDQLREKYLEGFDAFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKSLSALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHALLSKIEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLIMLQAGASMMDPNHFLMIMLSRFELYHIFSSADCRKRYSRENANKDVVQQNNTLIEEMLHLIIMIVGERYTAGVGQ-VEITDEIRREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVALFKKPGVTGRGLYKLRPECA-KMFNLYFHHYSRADQSKAEEAQRKIKRQNGEDSVLPPPVLPRFCPLFASLVNILQCDVLLGILGAVLQWAM-EPSGGHWSESMLQRVLHLIGMGLVEEQQHLISSAEDYNDTNFNFTLKISRPGEAPANTASILALLETLQNAPHLEVHKDMIRWILK----VKLIKSSLPSHLLLECICT-VRDKEKAE-----RKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEDLDPSTSSTLEHSPSSCDSALVCVGPRRWRAGGSDRRQVVTCILCQEEQEIRSDGKAMVLAAFVQRSTVMSKN---RKRPPH--------------------------------NPDKYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLSEQ------------------PDLSQWL-NITSHQMKALISAHRKSKTSSDMFLLIRNPY------SSTIKEMLTTFGTATYKVGLKVHPNEQDPRVP------------------IMCWGSCAYTIQSIERLLVDEEKPLFGSLPCRQDDCLSSLTRFGSACWTVSSHTTVQNH---------FIRLLAALVPD-------------PRVENTPCILDVDMFHLLVSLVLSHPAVLCLDSSG--------LSADAAQLHFLHLITVAHVVQILLTSLPEEVRMEQETGGAEREEEESVCLLY-----NTLRSLLGRGLREVSSGWHLWRCVKA--------GILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLP-------------SNLLQLYFNNLDIME-------PLLHGFPRESNHLIDLPGDYSALINQASSFTC---PKSGGDKSRVPTLCLVCGAMLCSQSYCCQ--TELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSITEEIGHAQEANQTLV 1706

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: UBR1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:NCBI gene;Acc:103040351])

HSP 1 Score: 359.762 bits (922), Expect = 2.476e-100
Identity = 444/1870 (23.74%), Postives = 771/1870 (41.23%), Query Frame = 1

Query:  184 FEKFIIGRNDKSIIE------SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTG---------VVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRY----ISVVKPLHRFMAALLI------DVKY-RNQLNVTETD--CLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTG-IVGKQSDKKAVLQR-AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGN---------LELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD------------------FTCILCQEKNTEENNRP-IVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNR---CPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWM---------------PNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVD-FTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLK--LSEAKTFW--NTPLPHVM---------PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCR-RIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
             E F+ G + +  +E      S  SS +CG++FK  E VY CRDCA D TCVLC  CF  S H  H Y+MH SSGGG+CDCGD EAWK    C+ H D   S A  T++ V         ++   L  ++ +F+    +    +     ++  EE+K          + ++      VLYN+E H+++ VI   +R + C    A ++  ++D++GR  A+    Q+  +  K+ I   ++  T   L   I H  +++ Q   + +  W  + I      R + C                +K  LI  +  +   ++K AR V    I  ++  ET +K+ F ++  ++YK +   +  DDH    S+ +L+ Q+FTV + A+ L+E       ++K+I + ++E                   +E +D N++F       D F R      DL+++L S                      A+W +     F++ F  F   L+ +Q  + ++R    H+E +P W+ G         ++ M+    C +    L+++ ++C         Q F +   D            SY    I +  P +     +S+  P+ R +A L +       V Y  + ++    D     + +L+ +V  +Q +  MW RNG      V Y   Q +KC     EMFD+D  +LQ+ A  + P  FI+  + +F+L     G    K  D      R  E+ L+ LII +  R+  G+   VTKED+    ++H LC++ M+HS L+K L  +     +  L ++I KVA   +   S   ++  KK   L +F+ +  +Y+    ++AE + K    +EGL   + PP+P       + ++  +S   +  +L + L   + +     W++ ++   L+L+G +L+E+   LE    E+    F      S K   IG+         L  +    S + Q ++I W+++    +K ++     S+     E D+   E      Q +  KA+AAK  R+ +M++M  MQK FI  +  L     +          ++SN  +  +                   TCILCQE+   +   P +VL A   RS VL ++               + L+T                  E S P          +    D A  T   +CGHVMH  C   Y + +    +N  R    +   + N    CPLCK +CN  +P+I    LNK++   + +  Q  + TL +W+                + GS+T K E    ++    + F  ++          SS+  + LV C  +   + ++  P+++      H   +  +                 YTI   D ++ E   ++   +  R   GL+ ++        QF+  + +  +          ML          A L L   +    ILE+D F F++G +L +     + N     S  +  +N    + ++V  +     +QVLLS ++ +       +  +          +    L+S   +L + + G    + +T + +A    + +L FLR A    + L  V  P   +   E  E        L+P+   SY +   N  +L  D +  ++     W  N  +  V+         P N  +LI+LP +++ ++       C   P++S    +  +LCL CG  +C    CC+ ++D   G  +     HA  C  G  +FL  R  ++V++  + R   Y  P YLD +GE+D  L RGNPL L  E Y KL + W  H I
Sbjct:   62 LECFLFGEDPRVGLEKLEHRNSGSSSQLCGRVFKEGETVYSCRDCAIDPTCVLCMDCFQNSVHKGHRYKMHGSSGGGFCDCGDLEAWKTGPCCSQH-DPGTSVAMETDDCV---------LEAELLERAQILFQVLLQYFTDLMVWEEEDELPEEMK----------NGMEEDTYYCVLYNDEQHSYDHVIYTLQRAISCDHNEAHTHTALIDKEGR-RAVRRGTQRSCQQAKDLIRSTAEQITQQPLRVEILHSALMARQTFALRLGPWFQQIIGYSVGFRQVFCQVALE------ASADGDKPCLISTLMLHDSRLYKGARKVIHEMIFCSLLMETEYKRQFAMKFTEHYKQLQKDFISDDHERNISVTALSVQIFTVPTLARQLIEE----GSVIKVIIDTVME-----------------MLREHLDSNQRFHFQGYNSDKFFRVQVIFHDLRYILIS--------------------RPAVWTEQLRGKFLEGFSVFLGLLNCMQGMEEVKRQFGQHIEVEPEWEAGFSIQIQLRHILSMFQDW-CSSDERVLLLAFQECHRALLRCTNQPFHSEPTD------------SYMCKHILHSRPYKVSQEPVSIHLPISRLLAGLYVLLCQTGAVTYLPDFVDPEHLDFCAFAEHSLRCVVLVAQVAAEMWRRNGLSLVSQVYYY--QDVKC---RDEMFDKDAIMLQIAASKMDPNHFIMLVLLRFELFEVFNGNCSSKDQDLLKQWNRLTEEMLYLLIIIIGERYVPGISI-VTKEDVTMREVIHLLCIEPMAHSSLVKGLPENESH--ETGLESVISKVATFKKPGVSGHGLYELKKE-CLKEFNPFFYHYTKSQHSKAEDAQKKRRAQEGLDKALRPPVPPPFCPAFSNIVWLLSCDVFIHVLRRVLQRAVEE-RSSLWSEAMIQRALHLLGQALIEEKTQLEASNVEEVTFDF------SHKARTIGSDHNKSLFHFLSKMKTLPSLEAQKDMINWLLQMFEIVKCLREK---SSPTALCEVDHAKPEES---VQDRKRKAEAAKLHRQKIMAQMSAMQKNFIETHKMLYDNVPESGGQGESSTSMESNAMELGERRVAVGPQQGVCPADWEALTCILCQEEQEVQAQAPAMVLTACVQRSTVLTQY-------------RGRTLST-----------------KESSYP----------LFMPPDLAVGTHTGSCGHVMHATCWQKYFEAVQNTTRN--RLHAEMIIDLENGEYMCPLCKSLCNTVVPLIPMQ-LNKLNYESAELVGQ--VLTLPRWIQIVLARIKGLRAAQEADSGSETAKEE--TGFFEDGQTDFRSILSFGVQPPPKYSSSITDMLVVCATTVHRVGLQTAPNEVC----PHVPVMTWN--------------TCAYTIQATDNMLQEEGKALFGSLQNRQLAGLKAVV--------QFSAVQRLKSSQTIIQKHFRDML---------AALLPLPNAEETPSILEIDYFHFLVGLVLSIPALYQEENVDLQPSAISTAYN----HLHLVHLVTMAHILQVLLSSQDSS------AMMAVMAGGEEEEEARAAAALYS---TLSQHIEG--LRASVTGSMIAERVKRGVLPFLRCAALFFNCLTGVPPPEELSSTAESSE-------SLLPYL-CSYLALPCNLFQLFQDHRDTVTPLIQRWCGNGAISKVLKGEMSTVRYPRNRNRLINLPEDYSILLNQASHFKC---PKSSDDERKHPTLCLFCGTMLCSQSPCCQVQLD---GEEVGACTAHAATCGAGVGMFLRVRECEIVLMASRTRGSTYPAP-YLDDYGETDPQLGRGNPLHLCPERYRKLHQLWQQHCI 1716

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:NCBI gene;Acc:103028332])

HSP 1 Score: 352.443 bits (903), Expect = 2.176e-98
Identity = 346/1293 (26.76%), Postives = 574/1293 (44.39%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLSSQVVIFNAKKSL---ILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQ-----SSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXX-RRELLMSKMWNMQKKFINENSELLTE-----------KKDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKT 3900
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S           ED   ++  + +A + +IF     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL   I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + F++    F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L +     +V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +++ +  R   G+G+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA  +     V       L       F+ Y  +YS  D+++AE + +   ++ G    + PP         A L+N +       +L   L   + +P+G +W++++L  VL+LIG +LLE+ + LE   E+    F F   I++     S+   ++  LE L +    +   ++I+WI++    IK M+     + S E   + +   E V+  ++ +  +     + RRE +M++M  MQ+ FINEN EL  +            +D  P + D   V             ++   TCILCQ E+    + R +VL A   RS V++K+      PPH                                NP   D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++    L K S S        W+ T SQ +   G K+
Sbjct:   80 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSLQ---------EDPLANLSADMIARTYNIFSIILKYAVD---MLTWDK-------EDELPQGLEPPERGDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALAWLGHIIRYSDALRRILC-----QVGLQKGPEG-ENSSLVDTLMLCDSKMWKGARNVYHQLFMSSLLMDLKYKKLFAIQFAKNYERLQSDYVKDDHDREFSITDLSVQMFTVPSLARMLITEENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISCPTE--------------------WTDKLREKFLEGLDGFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKCLTALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHVLLSKTEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLMMLQAGASMMDPNHFLMIVLSRFELFHIFSSADCRKRYNRENANKDVVQQNSTLIEEMLHLIMMVVGERFASGIGQ-VENSDELKREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVA--SFKKPGVTGRGLYELRPECAKQFNLYFYHYSRADQSKAEEAQRKLKRQNGEDSALPPPALPPFCPLFASLVNILQCDVLLGMLGAVLQWAV-EPSGGHWSESMLQRVLHLIGMALLEEQQQLESSCEDNEVTFNFTLKISRPGEAPSNTPSVLALLETLQNAPHLEVHKDIIRWILKMVVNIKTMRERTAAAPSPEG--SGHCQEETVRDKDKAERKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEELDASTSTSQDHSPSSWDSALVCVGPRRWRAGGGERRQVVTCILCQEEQEIRSDGRAMVLAAFVQRSTVMSKN---RRRPPH--------------------------------NPESYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLP---LAKTSCS-EQPGLSQWLNTTSQQIKTLGKKS 1246

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:NCBI gene;Acc:103028332])

HSP 1 Score: 353.214 bits (905), Expect = 3.123e-98
Identity = 346/1301 (26.59%), Postives = 577/1301 (44.35%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLSSQVVIFNAKKSL---ILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQ-----SSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXX-RRELLMSKMWNMQKKFINENSELLTE-----------KKDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVS 3924
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S           ED   ++  + +A + +IF     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL   I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q A+NY+ +   Y  DDH+ E S+  L+ Q+FTV S A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + F++    F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L +     +V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +++ +  R   G+G+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA  +     V       L       F+ Y  +YS  D+++AE + +   ++ G    + PP         A L+N +       +L   L   + +P+G +W++++L  VL+LIG +LLE+ + LE   E+    F F   I++     S+   ++  LE L +    +   ++I+WI++    IK M+     + S E   + +   E V+  ++ +  +     + RRE +M++M  MQ+ FINEN EL  +            +D  P + D   V             ++   TCILCQ E+    + R +VL A   RS V++K+      PPH                                NP   D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++    L K S S        W+ T SQ +    +  +K + A +
Sbjct:   93 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSLQ---------EDPLANLSADMIARTYNIFSIILKYAVD---MLTWDK-------EDELPQGLEPPERGDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALAWLGHIIRYSDALRRILC-----QVGLQKGPEG-ENSSLVDTLMLCDSKMWKGARNVYHQLFMSSLLMDLKYKKLFAIQFAKNYERLQSDYVKDDHDREFSITDLSVQMFTVPSLARMLITEENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISCPTE--------------------WTDKLREKFLEGLDGFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKCLTALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHVLLSKTEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLMMLQAGASMMDPNHFLMIVLSRFELFHIFSSADCRKRYNRENANKDVVQQNSTLIEEMLHLIMMVVGERFASGIGQ-VENSDELKREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVA--SFKKPGVTGRGLYELRPECAKQFNLYFYHYSRADQSKAEEAQRKLKRQNGEDSALPPPALPPFCPLFASLVNILQCDVLLGMLGAVLQWAV-EPSGGHWSESMLQRVLHLIGMALLEEQQQLESSCEDNEVTFNFTLKISRPGEAPSNTPSVLALLETLQNAPHLEVHKDIIRWILKMVVNIKTMRERTAAAPSPEG--SGHCQEETVRDKDKAERKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEELDASTSTSQDHSPSSWDSALVCVGPRRWRAGGGERRQVVTCILCQEEQEIRSDGRAMVLAAFVQRSTVMSKN---RRRPPH--------------------------------NPESYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLP---LAKTSCSSEQPGLSQWLNTTSQQIKTLHAAHRKAKSATA 1268

HSP 2 Score: 103.605 bits (257), Expect = 1.571e-21
Identity = 77/249 (30.92%), Postives = 112/249 (44.98%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG----EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM---PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            S+L +LR A    H L  V  P   +  G    E +  +  L  +L+    Y+Y     + LK +     S          P  +   P    KLI+LP +++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  LFL  R S+V++L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI   I     +N   V
Sbjct: 1509 SILPYLRGAALFFHHLNGVPTPPELHALGAGEWEALCTYLCLPSNLLQL-YYNY----QDVLKPLVKGWCSHPGMRQCLQSPETLISFPRESNKLIELPEDYSALINQASSFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELEGEDVGACTAHTFACGAGVGLFLRVRESQVLLLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCRERYRKIQKLWRQHSITEEIGHAQEANQTLV 1746

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:NCBI gene;Acc:103028332])

HSP 1 Score: 349.747 bits (896), Expect = 4.521e-97
Identity = 345/1301 (26.52%), Postives = 576/1301 (44.27%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQ--------TFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI-----DVKYR--NQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI-----VGKQSDKKAVLQR----AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLSSQVVIFNAKKSL---ILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLF-FDACINQ-----SSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXX-RRELLMSKMWNMQKKFINENSELLTE-----------KKDQHPVACDEDHV--------DSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYN------RCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVS 3924
            ++N  S +CG +FK  EP Y CR+CA D TCVLC  CF+ S H +H Y M TS GGG+CDCGD EAWK   +C  H  ++  S           ED   ++  + +A + +IF     + +     L+ +K       E E         +      +L+N+E H +EQVI   ++ + CT + A+S+A  VDRDGR  ++   D +  E  K+ I VR+ S+    L  ++ H  +++ Q   +  L WL   I     LR +LC     +  +Q G    E S+L+  +     +MWK ARNV     M+++  +  +KKLF +Q A+NY+ +   +  DDH    S+ SL+ QLFTV + A+ L+   N M  I++   +        LRH++++ R    F+ E     + F  F R    + DLK++L S  +                     W D   + F++    F   L  +Q  D + R +  H+E +P W+    +     + I++  +   S+ +       +L + +K  +  L + +          T ++  +S   I        +S+  P+ R +A L +     +V YR   QL ++E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+DL +LQ  A  + P  F++  + +F+L    +         +++  K V+Q+     E+ LH +++ +  R   G+G+ V   D     I+H LC++ M+HS+L+K L  +  K  +  +  +ID VA  +     V       L       F+ Y  +YS  D+++AE + +   ++ G    + PP         A L+N +       +L   L   + +P+G +W++++L  VL+LIG +LLE+ + LE   E+    F F   I++     S+   ++  LE L +    +   ++I+WI++    IK M+     + S E   + +   E V+  ++ +  +     + RRE +M++M  MQ+ FINEN EL  +            +D  P + D   V             ++   TCILCQ E+    + R +VL A   RS V++K+      PPH                                NP   D   M   +S   H       +CGH+MH  C   Y + +   +Q   R + +     Y+       CPLC+C+ N  IP++    L K S S        W+ T SQ +    +  +K + A +
Sbjct:   93 QNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSLQ---------EDPLANLSADMIARTYNIFSIILKYAVD---MLTWDK-------EDELPQGLEPPERGDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGR-KSVRFGDFQFCEQAKSVI-VRNTSRQTKPLRVQVMHSSVVAHQCFALKALAWLGHIIRYSDALRRILC-----QVGLQKGPEG-ENSSLVDTLMLCDSKMWKGARNVYHQLFMSSLLMDLKYKKLFAIQFAKNYQRLQTDFMEDDHERLVSVTSLSVQLFTVPTMARMLITEENLMTTIIRTFVDH-------LRHRDLQGR----FQFERYTAQQAFK-FRRVQSLIGDLKYVLISCPTE--------------------WTDKLREKFLEGLDGFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDER-------VLIEAYKKCLTALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHVLLSKTEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNG---FSLVNQIYYYHNVKCRV---EMFDKDLMMLQAGASMMDPNHFLMIVLSRFELFHIFSSADCRKRYNRENANKDVVQQNSTLIEEMLHLIMMVVGERFASGIGQ-VENSDELKREIVHQLCIRPMAHSELVKALPENENK--ETGMERVIDSVA--SFKKPGVTGRGLYELRPECAKQFNLYFYHYSRADQSKAEEAQRKLKRQNGEDSALPPPALPPFCPLFASLVNILQCDVLLGMLGAVLQWAV-EPSGGHWSESMLQRVLHLIGMALLEEQQQLESSCEDNEVTFNFTLKISRPGEAPSNTPSVLALLETLQNAPHLEVHKDIIRWILKMVVNIKTMRERTAAAPSPEG--SGHCQEETVRDKDKAERKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEELDASTSTSQDHSPSSWDSALVCVGPRRWRAGGGERRQVVTCILCQEEQEIRSDGRAMVLAAFVQRSTVMSKN---RRRPPH--------------------------------NPESYDPLFMHPDLSFGTHT-----GSCGHIMHSHCWQRYFEAVQAKEQR--RQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLP---LAKTSCSSEQPGLSQWLNTTSQQIKTLHAAHRKAKSATA 1268

HSP 2 Score: 103.99 bits (258), Expect = 1.432e-21
Identity = 77/249 (30.92%), Postives = 112/249 (44.98%), Query Frame = 1

Query: 4798 SLLSFLRIAVFMLHELGSVDIPTYFNVDG----EFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVM---PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            S+L +LR A    H L  V  P   +  G    E +  +  L  +L+    Y+Y     + LK +     S          P  +   P    KLI+LP +++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  LFL  R S+V++L  + +   Y  P YLD +GE+D  L+RGNPL L +E Y K+++ W  HSI   I     +N   V
Sbjct: 1509 SILPYLRGAALFFHHLNGVPTPPELHALGAGEWEALCTYLCLPSNLLQL-YYNY----QDVLKPLVKGWCSHPGMRQCLQSPETLISFPRESNKLIELPEDYSALINQASSFTC---PKSGGDKSRAPTLCLVCGTMLCSQSYCCQ--TELEGEDVGACTAHTFACGAGVGLFLRVRESQVLLLAGKTKGCFYAPP-YLDDYGETDQGLRRGNPLHLCRERYRKIQKLWRQHSITEEIGHAQEANQTLV 1746

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: UBR1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:NCBI gene;Acc:103040351])

HSP 1 Score: 313.153 bits (801), Expect = 8.336e-86
Identity = 419/1814 (23.10%), Postives = 739/1814 (40.74%), Query Frame = 1

Query:  334 CFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTG---------VVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRY----ISVVKPLHRFMAALLI------DVKY-RNQLNVTETD--CLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTG-IVGKQSDKKAVLQR-AEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGN---------LELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLD------------------FTCILCQEKNTEENNRP-IVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNR---CPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWM---------------PNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVD-FTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLK--LSEAKTFW--NTPLPHVM---------PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCR-RIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
            CF  S H  H Y+MH SSGGG+CDCGD EAWK    C+ H D   S A  T++ V         ++   L  ++ +F+    +    +     ++  EE+K          + ++      VLYN+E H+++ VI   +R + C    A ++  ++D++GR  A+    Q+  +  K+ I   ++  T   L   I H  +++ Q   + +  W  + I      R + C                +K  LI  +  +   ++K AR V    I  ++  ET +K+ F ++  ++YK +   +  DDH    S+ +L+ Q+FTV + A+ L+E       ++K+I + ++E                   +E +D N++F       D F R      DL+++L S                      A+W +     F++ F  F   L+ +Q  + ++R    H+E +P W+ G         ++ M+    C +    L+++ ++C         Q F +   D            SY    I +  P +     +S+  P+ R +A L +       V Y  + ++    D     + +L+ +V  +Q +  MW RNG      V Y   Q +KC     EMFD+D  +LQ+ A  + P  FI+  + +F+L     G    K  D      R  E+ L+ LII +  R+  G+   VTKED+    ++H LC++ M+HS L+K L  +     +  L ++I KVA   +   S   ++  KK   L +F+ +  +Y+    ++AE + K    +EGL   + PP+P       + ++  +S   +  +L + L   + +     W++ ++   L+L+G +L+E+   LE    E+    F      S K   IG+         L  +    S + Q ++I W+++    +K ++     S+     E D+   E      Q +  KA+AAK  R+ +M++M  MQK FI  +  L     +          ++SN  +  +                   TCILCQE+   +   P +VL A   RS VL ++               + L+T                  E S P          +    D A  T   +CGHVMH  C   Y + +    +N  R    +   + N    CPLCK +CN  +P+I    LNK++   + +  Q  + TL +W+                + GS+T K E    ++    + F  ++          SS+  + LV C  +   + ++  P+++      H   +  +                 YTI   D ++ E   ++   +  R   GL+ ++        QF+  + +  +          ML          A L L   +    ILE+D F F++G +L +     + N     S  +  +N    + ++V  +     +QVLLS ++ +       +  +          +    L+S   +L + + G    + +T + +A    + +L FLR A    + L  V  P   +   E  E        L+P+   SY +   N  +L  D +  ++     W  N  +  V+         P N  +LI+LP +++ ++       C   P++S    +  +LCL CG  +C    CC+ ++D   G  +     HA  C  G  +FL  R  ++V++  + R   Y  P YLD +GE+D  L RGNPL L  E Y KL + W  H I
Sbjct:    3 CFQNSVHKGHRYKMHGSSGGGFCDCGDLEAWKTGPCCSQH-DPGTSVAMETDDCV---------LEAELLERAQILFQVLLQYFTDLMVWEEEDELPEEMK----------NGMEEDTYYCVLYNDEQHSYDHVIYTLQRAISCDHNEAHTHTALIDKEGR-RAVRRGTQRSCQQAKDLIRSTAEQITQQPLRVEILHSALMARQTFALRLGPWFQQIIGYSVGFRQVFCQVALE------ASADGDKPCLISTLMLHDSRLYKGARKVIHEMIFCSLLMETEYKRQFAMKFTEHYKQLQKDFISDDHERNISVTALSVQIFTVPTLARQLIEE----GSVIKVIIDTVME-----------------MLREHLDSNQRFHFQGYNSDKFFRVQVIFHDLRYILIS--------------------RPAVWTEQLRGKFLEGFSVFLGLLNCMQGMEEVKRQFGQHIEVEPEWEAGFSIQIQLRHILSMFQDW-CSSDERVLLLAFQECHRALLRCTNQPFHSEPTD------------SYMCKHILHSRPYKVSQEPVSIHLPISRLLAGLYVLLCQTGAVTYLPDFVDPEHLDFCAFAEHSLRCVVLVAQVAAEMWRRNGLSLVSQVYYY--QDVKC---RDEMFDKDAIMLQIAASKMDPNHFIMLVLLRFELFEVFNGNCSSKDQDLLKQWNRLTEEMLYLLIIIIGERYVPGISI-VTKEDVTMREVIHLLCIEPMAHSSLVKGLPENESH--ETGLESVISKVATFKKPGVSGHGLYELKKE-CLKEFNPFFYHYTKSQHSKAEDAQKKRRAQEGLDKALRPPVPPPFCPAFSNIVWLLSCDVFIHVLRRVLQRAVEE-RSSLWSEAMIQRALHLLGQALIEEKTQLEASNVEEVTFDF------SHKARTIGSDHNKSLFHFLSKMKTLPSLEAQKDMINWLLQMFEIVKCLREK---SSPTALCEVDHAKPEES---VQDRKRKAEAAKLHRQKIMAQMSAMQKNFIETHKMLYDNVPESGGQGESSTSMESNAMELGERRVAVGPQQGVCPADWEALTCILCQEEQEVQAQAPAMVLTACVQRSTVLTQY-------------RGRTLST-----------------KESSYP----------LFMPPDLAVGTHTGSCGHVMHATCWQKYFEAVQNTTRN--RLHAEMIIDLENGEYMCPLCKSLCNTVVPLIPMQ-LNKLNYESAELVGQ--VLTLPRWIQIVLARIKGLRAAQEADSGSETAKEE--TGFFEDGQTDFRSILSFGVQPPPKYSSSITDMLVVCATTVHRVGLQTAPNEVC----PHVPVMTWN--------------TCAYTIQATDNMLQEEGKALFGSLQNRQLAGLKAVV--------QFSAVQRLKSSQTIIQKHFRDML---------AALLPLPNAEETPSILEIDYFHFLVGLVLSIPALYQEENVDLQPSAISTAYN----HLHLVHLVTMAHILQVLLSSQDSS------AMMAVMAGGEEEEEARAAAALYS---TLSQHIEG--LRASVTGSMIAERVKRGVLPFLRCAALFFNCLTGVPPPEELSSTAESSE-------SLLPYL-CSYLALPCNLFQLFQDHRDTVTPLIQRWCGNGAISKVLKGEMSTVRYPRNRNRLINLPEDYSILLNQASHFKC---PKSSDDERKHPTLCLFCGTMLCSQSPCCQVQLD---GEEVGACTAHAATCGAGVGMFLRVRECEIVLMASRTRGSTYPAP-YLDDYGETDPQLGRGNPLHLCPERYRKLHQLWQQHCI 1601

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003987.1 (pep scaffold:Pmarinus_7.0:GL476676:175215:200350:-1 gene:ENSPMAG00000003640.1 transcript:ENSPMAT00000003987.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 201.445 bits (511), Expect = 2.891e-54
Identity = 178/709 (25.11%), Postives = 285/709 (40.20%), Query Frame = 1

Query:  229 SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSA---------DSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDP-------FERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEW--PSRYISVVKPLHRFMAALLIDVKYRN------QLNVTETDC----LLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI---KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLL 2262
            SN  + +CG +F++ EP Y CR+CA D TCVLC  CF +S H  H Y ++   GGG C+ GD EAW+    C +H      +A         D  EE    L  V +   I+ L    S     ++F  +   KL L                            VLYN+E H F  VI      + C+   A S A+ VDR GR      + Q   E K+  +   S  +    L   +    + + Q     +L WL    +    LR+L+C  L S      G+ S     ++QD       +WK AR+V  + IM ++  E  +K+ F +   +NY+ +   +  DDH    S+ SL+ Q+FTV + A+YL+   + +  ++K +  +L                     +E M  N    P         R +    DLKF+L +  S                     W D     F+  FQ F  FL ++Q  + + R +  HVE DP W     +     + IT+      SN      ++ +  +  ++              L      ++   +    + +S   P+ RF+A L   V +        ++N+ E       L +  L+ LV  +Q +  MW RNG   + L  Q+          EMFD+D+ +LQ+ A  + P+ F+L  + +F+L+
Sbjct:   31 SNRPAQLCGHVFRSGEPTYSCRECAADPTCVLCMDCFQQSVHRTHRYRIYRVGGGGECEVGDREAWRTGPDCCMHSPGHADAAATVGVGVLPDGVEERARTLFPVLLQYAIDALTWDPSSGPLLRDFHPQTHTKLYL---------------------------CVLYNDEVHTFNDVIGCLVVAIGCSEREAFSLASAVDRQGRKSVYCGSQQVCEEIKRIIVGRSSPRRGQKALRTEVESASLFAHQTFATRLLAWLNHICETCEGLRVLVCEALLSG-----GDASPVCMLMLQDS-----RLWKGARSVHYDLIMGSLLLEAEYKRHFAIVFTRNYRRLQQDFLDDDHERNLSVTSLSVQVFTVPTLARYLVMEEDALSILVKTMREQL---------------------QELMGGNGALHPDRTDSVQLRRALHTFGDLKFILIARPSE--------------------WSDALRIKFLAGFQEFMTFLQVLQGIEAVTRQLSQHVEMDPEWDVAYSLELAVTHAITMMQGWCASNAAVLVESYALCVRVLQSSGAVPRNAAATPVRLALCGHSLLSMPYLVSRQPVSTHLPMTRFLAGLYAMVSHTGVMSSYPEMNLDEESVEPQDLAELPLRCLVLLAQVNAGMWRRNG---FSLANQMYHYHSAMCRQEMFDKDVLMLQIAASRMDPDEFLLLLLCRFELI 658

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001332.1 (pep scaffold:Pmarinus_7.0:GL484789:8763:12512:1 gene:ENSPMAG00000001198.1 transcript:ENSPMAT00000001332.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 105.916 bits (263), Expect = 1.641e-24
Identity = 88/283 (31.10%), Postives = 130/283 (45.94%), Query Frame = 1

Query:  175 FESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLC 1023
            ++  E+F   R +        +  +CG  FK  EP Y CR+CA D TCVLC  CF  S H  H Y M+ S GGG CDCGD EAWK    C++H   L +S     +    L   P D     +A ++++F     +    LC    E  T  L +E         + K      +L+N+E H +EQVI + ++ + C+ + A ++A  +DRDGR   L   + K  E  K  I   +       L  R+    +++ Q   + +L WL   I     LR +LC
Sbjct:   54 WDPLERFGALRQEAQ------TRQLCGHAFKMGEPTYSCRECAMDPTCVLCMECFQHSVHKSHRYRMNASGGGGLCDCGDVEAWKSGPFCDIH---LPASGTPDPDPTSRL---PSD----LVARAQAVFSIALRYAADMLCW--EEDDTLPLGLE--------PTRKGSAYYCMLFNDEVHTYEQVIYVLQKAVGCSQKEASNFATNIDRDGRKSVLYG-EHKLCEQAKAVIERSTGRGNQKPLKVRVMLAAVVAHQLFAMRLLAWLAHVISHSEGLRRVLC 309

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001634.1 (pep scaffold:Pmarinus_7.0:GL483984:3556:13608:-1 gene:ENSPMAG00000001467.1 transcript:ENSPMAT00000001634.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 92.0485 bits (227), Expect = 8.752e-19
Identity = 52/156 (33.33%), Postives = 76/156 (48.72%), Query Frame = 1

Query: 5056 KLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMS-LCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            +L+ LP +++ +I       C   P+  G  S    +CLVCG  +C   YCC+   E  G  +     H   C  G  +FL  R  +V++L  + +   Y  P YLD +GE+DV LKRGNPL L  E Y +L+R W  H +   I     +N  + 
Sbjct:  663 RLVPLPEDYSVLINQASRFTC---PRLEGDESRAPIMCLVCGTMLCSQSYCCQ--SELDGEDVGACTAHTYTCGAGVGIFLRVRLCQVLLLSAKTKG-CYYPPPYLDDYGETDVGLKRGNPLHLCPERYMRLQRLWQQHGVAEEIGHAQDANQSYT 812

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005762.1 (pep scaffold:Pmarinus_7.0:GL476923:1899:31331:-1 gene:ENSPMAG00000005218.1 transcript:ENSPMAT00000005762.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 67.0106 bits (162), Expect = 3.980e-11
Identity = 34/102 (33.33%), Postives = 48/102 (47.06%), Query Frame = 1

Query:  169 DYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHG-DSLKS 471
            + FE F + + G +D         +++CG ++ A    + CR C       LC  CF   EHT H++ M  S  GG CDCGD    +    C  HG  SL+S
Sbjct:   17 EAFEEFGRTVRGYDD---------AALCGLVWTANFVAFRCRTCGISPCMSLCAECFNAGEHTGHDFNMFRSQAGGACDCGDSSVMRESGFCQRHGRASLRS 109

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: UBR1 (E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) [Source:SGD;Acc:S000003416])

HSP 1 Score: 133.65 bits (335), Expect = 1.529e-31
Identity = 292/1360 (21.47%), Postives = 523/1360 (38.46%), Query Frame = 1

Query:  250 CGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNY--EMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDV---PVDVKINFLAISKSIFKYFKNFV---MRPL------CKLSLEKRTEE------------LKVEQEF-----------------ASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMS--YANIVDRDGRCMALTSTDQKD-------IESKKNEISVRSKSQTMMELLCR-----IHHPLIL-------SLQNLLIHIL------------------RWLYEFIDKYPKLRLLLCTYLFSENEMQIG-------ETSFEKSTLIQDI------------------FENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNC--QLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSK---------PLRHQNIENRLILHFEKE----EMDVNKKFDP-FERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDC-----LLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEM--FDRDLQLLQLMALC----VPPESFILKCVHKFDLLGYLTGIVGKQ----SDKKA-VLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLS-----SQVVIFNAKKSLI--------LSDFDRYVPYYSLQDRNEAELS---IKNFLKK---EGLSMTIHPPIPI-DLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLED-IKNLELPLEE---QRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEI--KLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRR------ELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHE-IDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLN 3813
            CG+ FK  EP+Y C +C  DDTCVLC  CF   +H  H+   ++ T    G CDCGDEEAW    HC         S D         EDV    V++ +  L +++ +F YF +     + PL        + L + T++            LK E ++                 AS  L+ I  +  ++++YN+E+HN+ Q  T  +   Q  P+        + +D +GR M   S D          +++     ++ S S+ + +  C+     I H L +       + +N++   L                  ++     DK    R +  + L   N++ +G        ++   S LI D+                  F+N    WK  R    N I+ T+     +K +F  Q+ + +  I    +  D  P+ + I   C  QLFT  + AK + E+ +F+D +  +I +   E+ K          ++  N+     + F++     E  ++K  DP      + +  L  L K    A+++ +  GE  +           +   NF+ Y +   +  S+IQ   T E+V E   +                   ++ +KL ++       A  I+  F   R +        T+ L   S  VI+       ++ + PL   ++ L+  V  ++     E DC     + D +L+ +V CSQ     W+RNG     +  Q       PE+  + RD+ L QL  L     +P    I   + +++LL + TG V  Q     DK + ++Q+   F++ ++    Y       K+  + D   ++I++ L +                  Y K  L ++ D + + T        +V +F   K L          S + +  P   L   NE E S   IK+ L K   E   + + P + I  L  D   L  +  N  + +++ K L +C+     D    T L+ +L+L+     +D + N +  + E    +P+        ++K D+    E +  K   D  LE  K I++K NE+   L+ + G+            ND ++ ++   + + + +  +KRR        L++K  N Q KF+ E+     E+ +      D D V   V++  DFTC LCQ+ ++ +     V+ A    S +          P +I               + NE    W     +      ID   + ++             +C H +H++C   Y++     K+ F+    +        CPLC+   N  +P+ ++   N
Sbjct:  123 CGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKEEDVWNDSVNIALVELVLAE-VFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDEYHNYSQATTALR---QGVPDNVHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWITHCLNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILADGNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFDNR--YWKRLRKDIQNVIIPTLASSNLYKPIFCQQVVEIFNHITRSVAYMDREPQLTAIR-ECVVQLFTCPTNAKNIFENQSFLDIVWSII-DIFKEFCKVEGGVLIWQRVQKSNLTKSYSISFKQGLYTVETLLSKVHDPNIPLRPKEIISLLTLCKLFNGAWKIKRKEGEHVL-----------HEDQNFISYLEYTTSIYSIIQ---TAEKVSEKSKD-------------------SIDSKLFLN-------AIRIISSFLGNRSL--------TYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSLKDAYEALE-DCSDFLKISDFSLRSVVLCSQIDVGFWVRNGMS---VLHQASYYKNNPELGSYSRDIHLNQLAILWERDDIP--RIIYNILDRWELLDWFTGEVDYQHTVYEDKISFIIQQFIAFIYQILTERQYFKTFSSLKD-RRMDQIKNSIIYNLYM--------------KPLSYSK-LLRSVPDYLTEDTTEFDEALEEVSVFVEPKGLADNGVFKLKASLYAKVDPLKLLNLENEFESSATIIKSHLAKDKDEIAKVVLIPQVSIKQLDKDALNLGAFTRNTVFAKVVYKLLQVCL-----DMEDSTFLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIANAKSDVFS--ESIVRK--ADYLLE--KMIMKKPNELFESLIASFGNQYV---------NDYKDKKLRQGVNLQETEKERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFDEQDN------DVDMVGEKVYESEDFTCALCQDSSSTDF---FVIPAYHDHSPIFR--------PGNI--------------FNPNEFMPMWDGFYNDDEKQAYIDDDVLEALKENGSCGSRKVFVSCNHHIHHNCFKRYVQ-----KKRFSSNAFI--------CPLCQTFSNCTLPLCQTSKAN 1340

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: UBR2 (Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex [Source:SGD;Acc:S000004014])

HSP 1 Score: 49.6766 bits (117), Expect = 5.603e-6
Identity = 34/105 (32.38%), Postives = 53/105 (50.48%), Query Frame = 1

Query: 5152 EMSLCLVCG------VTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKL 5448
            E+++CL+CG       ++ L GY      E +    +G +I +      Y +FL T  +  + L Y  R   Y  P YL K+GE++ D K G P++LN+  YA L
Sbjct: 1748 EIAVCLLCGQKCHIQKSIALQGYL---QGECTDHMRNGCEITS-----AYGVFLMT-GTNAIYLSYGKRGTFYAAP-YLSKYGETNEDYKFGTPVYLNRARYANL 1842

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: UBR1 (ubiquitin protein ligase E3 component n-recognin 1 [Source:NCBI gene;Acc:101162172])

HSP 1 Score: 396.741 bits (1018), Expect = 4.382e-112
Identity = 448/1864 (24.03%), Postives = 766/1864 (41.09%), Query Frame = 1

Query:  184 FEKFIIGRNDKSIIE----SNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKF-------DPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVN--------CITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLI------DVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNG-----SVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQ---RAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLE-----LLCDKI----SCDQQLELIKWIIRKCNEIKLM--KNSGHVSTSFEAM--ETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTE-------------------KKDQHPVACDEDHVDSNVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTK--GVLYPRIYNR---CPLCKCVCNIDIPIIKSDMLN---KVSNSISS-MSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSH------FNILMKHAT--PMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDY--AVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLF-------ILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIP-----TYFNVDGEFIELFRVLKLDLIPFSNYS-YPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSI 5475
             E F+ G + +  +E     + SS +CG++FK  E VY CRDCA D TCVLC  CF  S H  H Y+MH SSGGG+CDCGD EAWK+   C+ H D   ++A  T+E V    D+   VK  F    + + +Y  +F++         +   EL  E +         K      VLYN+E H+++ VI   +R + C  + A ++  ++D++GR  A+     +  +  K+ I   S+  ++  L   I H ++++ Q   I +  W  + I      R + C      N         ++  LI  +  +  +M+K AR +    I  ++  +T FKKLF ++  + YK +   + +DDH    S+ +L+ Q+FTV + A+ L+E  N    ++++I +                  I++  +E +D N +F       D F R      DL+++L S  S                    +W       F++ F+ F   L  +Q  + ++R +  H+  +P W+ G  +     +        C +    L+++ ++C         Q F+   +D        F +  +  HV   +     +S+  P+ R  A L +       +++ +     +   L +  L+ +V  +Q S  MW RNG      V Y   Q +KC     EM+D+D+ +LQ+ A  + P  F++  + +F+L  Y  G    + D+  ++Q     E+ L+ LI+ +  R+  G+ + VTKE++    ++H LC+        + K     + Y  G L  +I KVA   +   S    +  KK  ++ +F+ +  +YS    ++AE S K    KEG    + PP+P     D + ++  +S      +L   L     +    +WT+ ++   L+LIG +LLE+   LE    E+    F      S K  +IG+ +      L  KI    S D Q ++I W+++  + IK +  K+S  VS + E+   E    D E  +     +  KA+AAK  R+ +M++M  MQK FI  N  L                      K+ +  +A       +   +++  TCILCQ E+    +   +VL     RS VL +                  + T+ A  D +  +  ++       P  +  G              T   +CGHVMH  C   Y +      QN  R++    L   + N    CPLCK +CN  +P+I  + L+   + +  I   ++  +W++ L+  +    + +++ ++        G +      F  ++      P + SDS    E LV C  +   + ++  P++L                      L+ +       +TI   + ++ E +  I   +  R   GL+ ++        QFA  + +                 C+     R + D+    +P         ILEVDF  +L  L+    SL      D             Y F++V   +    +QVLL+  +      D    +     + +++            ++ +Q G    I DL+ + VA    K +  FLR A    + L  V  P     T     G+   L   L L    F  +  Y   IS  L+       + AK           P    +LIDLP +++ ++       C  S        + +LCL CGV +C    CC  + +  G  +     HA  C  G  +FL  R  ++V++  ++R   Y  P YLD +GE+D  L RGNPL L  E Y KL + W  H I
Sbjct:   62 LECFLFGEDPQQGLEKLKQGSTSSQLCGRVFKEGETVYSCRDCAIDPTCVLCMDCFQDSVHKSHRYKMHASSGGGFCDCGDVEAWKIGPCCSKH-DPGAATAMVTDEWVLE-PDLCERVKKLF----RVLLRYLTDFLVW--------EENFELSAELQ------PGTKENAYYCVLYNDEHHSYDHVIYTLQRSVNCNQDEAKTHTTLIDKEGR-RAVKRGTLRSCQQAKDLIKSNSEHISLQPLRVEILHAVVMAHQTFAIRLGSWFQKIIGYSVGFRQVFCQVALEPN------ADRDRPCLISRLMLHDAKMYKGARKIVHELIFCSMLMDTEFKKLFAIEFTKYYKQLQKDFIVDDHERSISITALSVQIFTVPTLARQLMEECN----VIRVIVDT-----------------IMYLLQEHLDDNNRFYFLGYNSDKFARIQIIFHDLRYVLISKPS--------------------VWTHQLRRQFVEGFRVFLGLLKCMQGMEEVKRQLSQHIAVEPEWEAGFTLQIQMRHILSMFQDWCASDEEILLLAFKECHTVLTRCDNQPFRKEAID--------FYMCKHILHVQPYKVSQDPVSIHLPISRLFAGLYVLLCGTGVIEHLDNPESYDFTQLAEHPLRCIVLAAQVSAEMWRRNGLSLVSQVYYY--QDVKC---RDEMYDKDIIMLQIAASKMDPNHFLMLVLLRFELFEYFNGCCSSK-DQDQLMQWNRLTEEMLYLLIVIIGERYVPGISR-VTKEEVTMREVIHLLCI-EPMAHSSLVKSLPENENYETG-LEAVISKVATFKKPGVSGHGRYEVKKDRLI-EFNPFFYHYSKSQHSKAEESQKKRKAKEGSEKALPPPVPPAFCPDFSNIVRLLSCDIIVHILRHVLQRA-AEEQPTHWTEAMIQRALHLIGQALLEEKTQLEACTVEEVTFDF------SLKARLIGSEQDKSVFYLLSKIKTLPSIDAQKDMIMWLLQMFDIIKCLREKSSPTVSMATESAKPEESAQDKEKAE-----RKRKAEAAKLHRKRIMAQMSAMQKNFIESNKMLYDNMPESGIQGEPTPAAQSCAVKQKELCIAIGPQRGSTQAEREV-LTCILCQEEQEVLPHAAAMVLTVCVQRSTVLTQ--------------CRGKIPTIKA--DGSGTYPLFT-------PPNLAIG--------------THTGSCGHVMHATCWQKYFEA----DQNTTRSRLHAELIIDLENGEYLCPLCKSLCNTVVPLIPLEPLSFDYENAGIIGQHLTLPHWIQVLTSRIKGLKALSQENDLIADGSGSSGVYGDSQPDFRSILSFGVQEPRRFSDSVT--EMLVVCATTVHRVGLRTAPNELCP--------------------LVPVMAWNTCAFTIHAIENVLQEEDKPIFGSLQNRQLAGLKAIV--------QFAASQRLK----------------CSQAVVQRHFKDMMGVLLPAMSRNNTPSILEVDFFHLLVGLVLSMPSLYQEEAVDLEPSSVSAAYNHLYIFHLVTMAH---MLQVLLTSTDFP-PAADGEETEEARAAAELYT------------TVSKQTGR--LIPDLSGSSVAQRVKKGIEPFLRCAALFFNYLTGVHPPEELFQTSVTSQGQMEALCNYLALPFNVFQLFQDYRDTISLLLQRWCG-SPAVAKALKGKTQTVSYPRRRNRLIDLPEDYSVLLNQASHFQCPKS--TDDERKQPTLCLFCGVMLCSQSSCC--LSQLDGEKVGACTAHAATCGAGVGMFLRIRECEIVLMASKSRGSTYPAP-YLDDYGETDPHLGRGNPLHLCPERYRKLNQLWQQHCI 1715

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:NCBI gene;Acc:101171104])

HSP 1 Score: 301.982 bits (772), Expect = 3.320e-82
Identity = 329/1305 (25.21%), Postives = 576/1305 (44.14%), Query Frame = 1

Query:  226 ESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESY--------------------NFMDDIMKLIYNK---LIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAY---RVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAF-EILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALL-------IDVKYRNQLNVTE--TDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQI------KCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGI----VGKQSDKKAVLQRA--EDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVA--DQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDA----CINQS--SKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDS-----------------NVHKKLDFTCILCQ-EKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEM-MKLKQNFARTKGVLYPRIYNR---CPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKK 3906
            E+N  S++CG +FK  EP Y CR+CA D TCVLC  CF++S H +H Y M TS GGG+CDCGD EAWK    C  H    ++     E+ V  L   P D+      +   I KY  +        L+ E+       E +  +      ++     V++N+E H +EQVI   ++ + C+ + A+S+A  VDR+GR  ++   D +  E  K+ I VR+KS+    L  ++ H  +++ Q   +  L WL + I     LR +LC     +  +Q G    E S+L+  +  N   MWK AR++    +M ++  +  FKK+F +Q A+NY+ +   +  DDH    S+ SL+ QLFTV +     L S                     +  +D +K  +++   + + S  +       R+++  E     + + F    RH       +F   +   A+   RV   +G+         + W D     F++ F    + L+ +Q  D + R +  H+E +P W+    +     + I++  +   ++ +   +A+ + L    +     L+ +   + ++  +       +     +S+  P+ R +A L        +  ++  QL + E     L++  L+ LV C+Q    MW RNG   + L  QI      KC     EMFD+D  +LQ  A  + P  F++  + +F+L    +        ++++K  V Q    E+ LH +I+ +  R+  GVGK    E++    I+H L ++ M+HS+L+K L  +  K  +  L  +ID VA   +   +   ++  +       F+ Y  +YS  D+++AE + K   ++ G    + PP+P  L      L+N +       + +  L   + +P G  WT+++L  VL+L+G +LLE+ + LE    E    F       C  ++  S   I+  LE L +    +   ++I WI++    IK+++     ++S       +  +   +   +    KA+ A+ RRE +M++M  MQK FINEN E+  +  ++  V+  E    S                    ++    CILCQ E+      + +VL A   RS VL+++   S LP                                  +P   D   M + +S+  H       +CGHVMH  C   Y + + +K ++   R +G     + N    CPLC+C+ N  IP++    L    +S+  +S + W++  SQ +    S  +K
Sbjct:   96 ENNCPSALCGHVFKVGEPTYSCRECAADPTCVLCMQCFLESAHRQHRYRMTTSGGGGFCDCGDPEAWKNDPWCQKHA---RADGHIEEDPVAQL---PPDLITRAYRVFFIILKYAVDL-------LTWEQ-------EDQLPAGLEPPERADTYFCVVFNDEVHTYEQVIYTLQKAVSCSHKEALSFATAVDREGR-KSVRFGDFQFCEQAKS-IIVRNKSRQAKPLRVQVMHSSVVAHQCFALKTLTWLGQIIKYSDGLRRILC-----QVGLQQGPEG-ENSSLVDRLMLNDSRMWKGARSIYHQLLMNSVLMDLKFKKVFAIQFAKNYRSLQTDFLEDDHERVVSVTSLSVQLFTVPTVVSTSLSSACHTPPSFSVCPPPSWCQNYEHLQNDYVKDDHDREFSITDLSVQMFTVPSLARMLMVEENLMTTIIRTFVDHLRHRDVHGRFQFDRYTAQQAFKFGRVQSLIGDLKYVLISPPSEWSDALRLKFLEGFDAVLDLLTCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMIQEWCSTDERVLIQAYRKCLSALTQCHGGLLDGEPPVSLSMAGHCVDTFRYQVSQDKVSIHLPVCRLLAGLHVLLSRTEVASRFPEQLPLGELSPHLLIELPLRCLVLCAQVHAGMWRRNG---FSLINQIYYYHNVKCRL---EMFDKDTIMLQAGASMMDPNHFLMMVLSRFELFHIFSSADIRKRFREANKDFVQQNTLIEEMLHLIIMVIGERYVAGVGKVEPLEEVR-REIIHQLSIRPMAHSELVKALPENGNK--ETGLERVIDSVALFKKPGVTGRGLYELRPE-CFKHFNLYFHHYSRADQSKAEEAQKKLRRQRGEDAALPPPLPPPLCPLFGSLVNLLQCDVLLAVESAVLQWAM-EPGGGGWTESMLQRVLHLVGMALLEEQQQLENSSGEDHVTFNYTSRIICPGEAPTSSGSILALLETLQNAPHLEVHKDMITWILKIIRNIKMIRERTSSASSIPVSPGGHELMREKEKAER--KRKAEMARLRREKIMAQMSEMQKNFINENKEMFQQSGEEMGVSTVEHSFPSLELTCASQVCVGPRRVGGSERRQQVICILCQEEQEVSGRGQAMVLAAFIQRSTVLSRNRHCS-LP----------------------------------DPEHYDPLFMHTNLSLGIHT-----ASCGHVMHATCWQRYFEAVQLKEQRRQQRLRGHTSYDVENGEFLCPLCECLSNTVIPLLPHTPLP--DHSVDHLSLEAWLKKTSQQVEALNSTPRK 1317

HSP 2 Score: 101.679 bits (252), Expect = 7.550e-21
Identity = 60/161 (37.27%), Postives = 80/161 (49.69%), Query Frame = 1

Query: 5041 PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            P    KLIDLP +++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  LFL  R S+V+ +  + +   Y  P +LD +GE+D  LKRGNPL L  E Y K+ER W  H I  VI     +N   V
Sbjct: 1637 PRESNKLIDLPEDYSILINQASSFTC---PRSGGDKSRAPTLCLVCGAMLCSQSYCCQV--EVDGEDVGACTAHTFTCGAGVGLFLRVRESQVLFVAGKTKGCFY-PPPFLDDYGETDQGLKRGNPLHLCLERYRKIERLWRQHGIPEVIGHAQEANQTLV 1791

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: ubr2 (ubiquitin protein ligase E3 component n-recognin 2 [Source:NCBI gene;Acc:101171104])

HSP 1 Score: 98.9821 bits (245), Expect = 2.189e-21
Identity = 63/168 (37.50%), Postives = 83/168 (49.40%), Query Frame = 1

Query: 5041 PFNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEM-SLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV*EIDDTH 5541
            P    KLIDLP +++ +I       C   P++ G  S   +LCLVCG  +C   YCC+   E  G  +     H   C  G  LFL  R S+V+ +  + +   Y  P +LD +GE+D  LKRGNPL L  E Y K+ER W  H I  VI     +N   V  ID  H
Sbjct:  194 PRESNKLIDLPEDYSILINQASSFTC---PRSGGDKSRAPTLCLVCGAMLCSQSYCCQV--EVDGEDVGACTAHTFTCGAGVGLFLRVRESQVLFVAGKTKGCFY-PPPFLDDYGETDQGLKRGNPLHLCLERYRKIERLWRQHGIPEVIGHAQEANQTLV-AIDWQH 354

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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: ubr3 (ubiquitin protein ligase E3 component n-recognin 3 [Source:NCBI gene;Acc:101159147])

HSP 1 Score: 90.8929 bits (224), Expect = 1.484e-17
Identity = 72/250 (28.80%), Postives = 116/250 (46.40%), Query Frame = 1

Query: 4765 TPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFS--------NYSYPSWISNQLKLISD-----LKLSEAKTFWNTPLPHVMP-FNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHS 5472
            +P  V V   +  L FLR++  + H L   D  T    + EF  L   + L L+P S        + S   W  +   L+S        LS+ +      L    P +  P+L+ LP+ +  +      + C++  +      + +LCLVCG  VCL G CC++        I    +H++ C     +FL   N+ V+++    R+ ++   IYLD  GE D DL+RG PLFL +E Y  LE+ W++H+
Sbjct: 1607 SPQSVEVSLQQFCLPFLRLSCLLQHHLYG-DSLTGCLEEEEFSSL--AVCLGLLPSSPQPSNAMHSASCLEWPVSAFDLVSQWCAEVTGLSQMQAEQTLTLLVQDPQWAAPRLLQLPDNYNIIFQYYHRKACTVCKKVP---KDPALCLVCGAFVCLKGVCCKQQG------ICECVLHSQHCGAAAGIFLLI-NASVIIIIRGHRFCLW-GSIYLDAHGEEDRDLRRGKPLFLCEERYRVLEQQWVSHT 1842

HSP 2 Score: 62.3882 bits (150), Expect = 5.289e-9
Identity = 39/138 (28.26%), Postives = 61/138 (44.20%), Query Frame = 1

Query:  178 ESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMR 591
            E FE+F         + S  ++++CG ++ A    Y CR C       LC  CF   +HT H++ M  S  GG CDCGD    +    C  H   LK+            E+VP  +  + L +S+ +   F  F+++
Sbjct:   80 EGFEEFC------KTVRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFNNGDHTSHDFNMFRSQAGGACDCGDGNVMRDSGFCRRH--RLKTG-----------ENVP-SIPCDLLLMSEMVLPRFILFIIQ 197

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: ubr3 (ubiquitin protein ligase E3 component n-recognin 3 [Source:NCBI gene;Acc:101159147])

HSP 1 Score: 90.5077 bits (223), Expect = 1.744e-17
Identity = 72/250 (28.80%), Postives = 116/250 (46.40%), Query Frame = 1

Query: 4765 TPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFS--------NYSYPSWISNQLKLISD-----LKLSEAKTFWNTPLPHVMP-FNPPKLIDLPNEFTEVITMGLDRGCSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHS 5472
            +P  V V   +  L FLR++  + H L   D  T    + EF  L   + L L+P S        + S   W  +   L+S        LS+ +      L    P +  P+L+ LP+ +  +      + C++  +      + +LCLVCG  VCL G CC++        I    +H++ C     +FL   N+ V+++    R+ ++   IYLD  GE D DL+RG PLFL +E Y  LE+ W++H+
Sbjct: 1618 SPQSVEVSLQQFCLPFLRLSCLLQHHLYG-DSLTGCLEEEEFSSL--AVCLGLLPSSPQPSNAMHSASCLEWPVSAFDLVSQWCAEVTGLSQMQAEQTLTLLVQDPQWAAPRLLQLPDNYNIIFQYYHRKACTVCKKVP---KDPALCLVCGAFVCLKGVCCKQQG------ICECVLHSQHCGAAAGIFLLI-NASVIIIIRGHRFCLW-GSIYLDAHGEEDRDLRRGKPLFLCEERYRVLEQQWVSHT 1853

HSP 2 Score: 62.7734 bits (151), Expect = 4.991e-9
Identity = 39/138 (28.26%), Postives = 61/138 (44.20%), Query Frame = 1

Query:  178 ESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMR 591
            E FE+F         + S  ++++CG ++ A    Y CR C       LC  CF   +HT H++ M  S  GG CDCGD    +    C  H   LK+            E+VP  +  + L +S+ +   F  F+++
Sbjct:   80 EGFEEFC------KTVRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFNNGDHTSHDFNMFRSQAGGACDCGDGNVMRDSGFCRRH--RLKTG-----------ENVP-SIPCDLLLMSEMVLPRFILFIIQ 197

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000029933.1 (SMESG000029933.1)

HSP 1 Score: 3360.08 bits (8711), Expect = 0.000e+0
Identity = 1685/1685 (100.00%), Postives = 1685/1685 (100.00%), Query Frame = 1

Query:   61 MKNFDEKFLDVLCDXXXXXXXXXXXXXXXXXXXXXXDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG 5115
            MKNFDEKFLDVLCDKSQLLCKPSSSPSPEEEYQSCSDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVKSMSHSKLMKKLSASLQKYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMKIAKADAAKKRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRSSFSESSSQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG
Sbjct:    1 MKNFDEKFLDVLCDKSQLLCKPSSSPSPEEEYQSCSDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVKSMSHSKLMKKLSASLQKYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMKIAKADAAKKRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRSSFSESSSQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG 1685

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000029933.1 (SMESG000029933.1)

HSP 1 Score: 3353.92 bits (8695), Expect = 0.000e+0
Identity = 1684/1686 (99.88%), Postives = 1685/1686 (99.94%), Query Frame = 1

Query:   61 MKNFDEKFLDVLCDXXXXXXXXXXXXXXXXXXXXXXDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVXXXXXXXXXXXXXXXXXXYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMXXXXXXXXXXRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRXXXXXXXXQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYF-NVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG 5115
            MKNFDEKFLDVLCDKSQLLCKPSSSPSPEEEYQSCSDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVKSMSHSKLMKKLSASLQKYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMKIAKADAAKKRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRSSFSESSSQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYF +VDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG
Sbjct:    1 MKNFDEKFLDVLCDKSQLLCKPSSSPSPEEEYQSCSDYFESFEKFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTEEIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKVEQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSYANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLILSLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLIQDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHHYSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEYSKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTSAYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTIERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILRQFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAALLIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQIKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGKQSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCVKSMSHSKLMKKLSASLQKYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLILSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQLLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDIKNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWIIRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMKIAKADAAKKRRELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFTCILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLTTVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTCGHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIPIIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKLGSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTYKHFETIRSSFSESSSQELIELDYAVMYTISVWDRIMLEHNTSILADIPERHANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHRAWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFNKENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDKNVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLHELGSVDIPTYFTDVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDLKLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRG 1686

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000029925.1 (SMESG000029925.1)

HSP 1 Score: 288.115 bits (736), Expect = 1.621e-89
Identity = 135/135 (100.00%), Postives = 135/135 (100.00%), Query Frame = 1

Query: 5116 CSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 5520
            CSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV
Sbjct:   25 CSLSPQASGTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVINDGFLSNDFFV 159

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000077583.1 (SMESG000077583.1)

HSP 1 Score: 77.7962 bits (190), Expect = 8.318e-14
Identity = 48/149 (32.21%), Postives = 75/149 (50.34%), Query Frame = 1

Query: 5050 PPKLIDLPNEFTEVITMGLDRGCSLSPQAS-GTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQ--ARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVI 5487
            PPKLI LP+ + ++        C+ + +A      E  LCL+CG  +CL       I +S     +    H + C  G  L ++   S + VL     ++W      +YLD +GE D++LKRG PLF+N   ++ LE+ WL+HS   V+
Sbjct: 1648 PPKLISLPHSYDDLFNAYHSEKCANTNKAPPHNFPENGLCLICGKLICL-------ICDSMPLAFNE---HTKSCCFGIGLIIDVNTSIIHVLLNNEISQW----GSVYLDFYGEEDLELKRGRPLFINSRRFSLLEQQWLSHSFKHVV 1782

HSP 2 Score: 62.3882 bits (150), Expect = 4.916e-9
Identity = 35/114 (30.70%), Postives = 50/114 (43.86%), Query Frame = 1

Query:  187 EKFIIGRND-----KSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDS-LKSSADSTEEIVYYLE 510
            + FI G +      K+ ++S   S+ CG ++      Y CR C    +  LC  CF    H  H++    S  GG CDCG+    K F +C  HG S L    D  E +   L+
Sbjct:   67 KAFIAGEDGDFDQYKAKLKSYDFSATCGLVWTTNYFAYRCRTCCLSPSMSLCGACFNNGNHIGHDFNKFKSQAGGACDCGNSYVMKEFGYCRHHGPSKLSQQRDPPENLTMRLK 180

[Close]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000077583.1 (SMESG000077583.1)

HSP 1 Score: 77.7962 bits (190), Expect = 8.752e-14
Identity = 48/149 (32.21%), Postives = 75/149 (50.34%), Query Frame = 1

Query: 5050 PPKLIDLPNEFTEVITMGLDRGCSLSPQAS-GTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYALFLNTRNSKVVVLFYQ--ARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAYAKLERNWLNHSIGCVI 5487
            PPKLI LP+ + ++        C+ + +A      E  LCL+CG  +CL       I +S     +    H + C  G  L ++   S + VL     ++W      +YLD +GE D++LKRG PLF+N   ++ LE+ WL+HS   V+
Sbjct: 1650 PPKLISLPHSYDDLFNAYHSEKCANTNKAPPHNFPENGLCLICGKLICL-------ICDSMPLAFNE---HTKSCCFGIGLIIDVNTSIIHVLLNNEISQW----GSVYLDFYGEEDLELKRGRPLFINSRRFSLLEQQWLSHSFKHVV 1784

HSP 2 Score: 62.3882 bits (150), Expect = 5.000e-9
Identity = 35/114 (30.70%), Postives = 50/114 (43.86%), Query Frame = 1

Query:  187 EKFIIGRND-----KSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICFIKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDS-LKSSADSTEEIVYYLE 510
            + FI G +      K+ ++S   S+ CG ++      Y CR C    +  LC  CF    H  H++    S  GG CDCG+    K F +C  HG S L    D  E +   L+
Sbjct:   67 KAFIAGEDGDFDQYKAKLKSYDFSATCGLVWTTNYFAYRCRTCCLSPSMSLCGACFNNGNHIGHDFNKFKSQAGGACDCGNSYVMKEFGYCRHHGPSKLSQQRDPPENLTMRLK 180

The following BLAST results are available for this feature:

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBR2	3.403e-92	27.54	ubiquitin protein ligase E3 component n-recognin 2...	[more]
UBR2	3.994e-90	27.22	ubiquitin protein ligase E3 component n-recognin 2...	[more]
UBR1	2.623e-82	24.82	ubiquitin protein ligase E3 component n-recognin 1...	[more]
UBR1	4.185e-74	25.21	ubiquitin protein ligase E3 component n-recognin 1...	[more]
UBR2	6.031e-49	35.26	ubiquitin protein ligase E3 component n-recognin 2...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ubr-1	1.684e-34	22.53	E3 ubiquitin-protein ligase ubr-1 [Source:UniProt...	[more]
F10G7.10	2.055e-10	26.96	pep chromosome:WBcel235:II:4713674:4726264:-1 gene...	[more]
F10G7.10	3.027e-6	32.94	pep chromosome:WBcel235:II:4713674:4726264:-1 gene...	[more]
F10G7.10	3.066e-6	32.94	pep chromosome:WBcel235:II:4718646:4726264:-1 gene...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ubr1	7.666e-58	23.03	gene:FBgn0030809 transcript:FBtr0346190	[more]
Ubr1	7.666e-58	23.03	gene:FBgn0030809 transcript:FBtr0308839	[more]
Ubr1	7.666e-58	23.03	gene:FBgn0030809 transcript:FBtr0074415	[more]
Ubr3	1.173e-16	27.35	gene:FBgn0260970 transcript:FBtr0331299	[more]
Ubr3	1.183e-16	27.35	gene:FBgn0260970 transcript:FBtr0301748	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ubr2	1.146e-118	24.97	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr2	5.206e-118	25.28	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr1	1.167e-44	27.75	ubiquitin protein ligase E3 component n-recognin 1...	[more]
LO018474.1	2.068e-23	25.75	ubiquitin protein ligase E3 component n-recognin 1...	[more]
BX248117.1	9.400e-22	29.55	pep chromosome:GRCz11:CHR_ALT_CTG13_1_2:3265968:32...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nup62	1.089e-115	25.38	nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257...	[more]
nup62	1.322e-112	25.29	nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257...	[more]
nup62	8.366e-112	25.29	nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257...	[more]
nup62	4.411e-89	27.01	nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257...	[more]
nup62	1.875e-85	26.37	nucleoporin 62kDa [Source:Xenbase;Acc:XB-GENE-6257...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ubr2	6.301e-88	26.99	ubiquitin protein ligase E3 component n-recognin 2...	[more]
Ubr2	3.392e-86	26.68	ubiquitin protein ligase E3 component n-recognin 2...	[more]
Ubr1	6.531e-82	24.54	ubiquitin protein ligase E3 component n-recognin 1...	[more]
Ubr3	2.087e-16	26.02	ubiquitin protein ligase E3 component n-recognin 3...	[more]
Ubr3	2.088e-16	26.02	ubiquitin protein ligase E3 component n-recognin 3...	[more]

BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8IWV8\|UBR2_HUMAN	1.918e-89	27.22	E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens O...	[more]
sp\|Q6WKZ8\|UBR2_MOUSE	2.373e-85	26.68	E3 ubiquitin-protein ligase UBR2 OS=Mus musculus O...	[more]
sp\|Q8IWV7\|UBR1_HUMAN	1.260e-81	24.82	E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens O...	[more]
sp\|O70481\|UBR1_MOUSE	4.568e-81	24.54	E3 ubiquitin-protein ligase UBR1 OS=Mus musculus O...	[more]
sp\|Q9VX91\|UBR1_DROME	7.685e-57	23.03	E3 ubiquitin-protein ligase UBR1 OS=Drosophila mel...	[more]

BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4W3H6V2	6.082e-121	26.15	E3 ubiquitin-protein ligase OS=Callorhinchus milii...	[more]
A0A4W3H8E2	2.228e-119	26.42	E3 ubiquitin-protein ligase OS=Callorhinchus milii...	[more]
F1Q745	2.564e-115	24.97	E3 ubiquitin-protein ligase (Fragment) OS=Danio re...	[more]
B3DM65	4.028e-115	25.48	E3 ubiquitin-protein ligase (Fragment) OS=Xenopus ...	[more]
B7ZDA3	1.165e-114	25.28	E3 ubiquitin-protein ligase OS=Danio rerio OX=7955...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBR1	2.476e-100	23.74	ubiquitin protein ligase E3 component n-recognin 1...	[more]
ubr2	2.176e-98	26.76	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr2	3.123e-98	26.59	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr2	4.521e-97	26.52	ubiquitin protein ligase E3 component n-recognin 2...	[more]
UBR1	8.336e-86	23.10	ubiquitin protein ligase E3 component n-recognin 1...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000003987.1	2.891e-54	25.11	pep scaffold:Pmarinus_7.0:GL476676:175215:200350:-...	[more]
ENSPMAT00000001332.1	1.641e-24	31.10	pep scaffold:Pmarinus_7.0:GL484789:8763:12512:1 ge...	[more]
ENSPMAT00000001634.1	8.752e-19	33.33	pep scaffold:Pmarinus_7.0:GL483984:3556:13608:-1 g...	[more]
ENSPMAT00000005762.1	3.980e-11	33.33	pep scaffold:Pmarinus_7.0:GL476923:1899:31331:-1 g...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
UBR1	1.529e-31	21.47	E3 ubiquitin ligase (N-recognin); heterodimerizes ...	[more]
UBR2	5.603e-6	32.38	Cytoplasmic ubiquitin-protein ligase (E3); compone...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBR1	4.382e-112	24.03	ubiquitin protein ligase E3 component n-recognin 1...	[more]
ubr2	3.320e-82	25.21	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr2	2.189e-21	37.50	ubiquitin protein ligase E3 component n-recognin 2...	[more]
ubr3	1.484e-17	28.80	ubiquitin protein ligase E3 component n-recognin 3...	[more]
ubr3	1.744e-17	28.80	ubiquitin protein ligase E3 component n-recognin 3...	[more]

BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000029933.1	0.000e+0	100.00	SMESG000029933.1	[more]
SMESG000029933.1	0.000e+0	99.88	SMESG000029933.1	[more]
SMESG000029925.1	1.621e-89	100.00	SMESG000029925.1	[more]
SMESG000077583.1	8.318e-14	32.21	SMESG000077583.1	[more]
SMESG000077583.1	8.752e-14	32.21	SMESG000077583.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013828 ID=SMED30013828|Name=E3 ubiquitin-protein ligase|organism=Schmidtea mediterranea sexual|type=transcript|length=5796bp
ATTCTGAGTATTAATTAAGATTATATATTTATTAAGTTTATGGACACTAA
TATTTCTGAAATGAAAAACTTCGATGAAAAATTTCTTGATGTTCTTTGTG
ACAAATCTCAACTATTATGCAAACCATCATCATCTCCTTCACCCGAAGAA
GAATATCAATCATGCAGTGATTATTTTGAATCATTTGAAAAGTTTATTAT
TGGTAGAAACGATAAATCGATCATTGAATCAAATGTAAGTAGTTCTATAT
GTGGGAAAATTTTCAAAGCCCGCGAACCAGTATATATTTGCAGAGATTGC
GCTACAGATGATACTTGCGTTTTGTGTAGAATATGCTTTATTAAAAGCGA
GCATACAAAACATAATTACGAGATGCATACCTCGTCTGGAGGAGGTTATT
GTGATTGTGGAGATGAAGAAGCATGGAAATTATTTTCTCATTGCAATTTG
CACGGAGATTCATTGAAAAGTTCTGCTGATTCAACCGAAGAAATCGTCTA
CTATTTAGAAGATGTACCGGTTGATGTTAAAATTAATTTTCTCGCTATTT
CTAAATCGATTTTTAAATATTTCAAAAATTTTGTCATGCGGCCTCTTTGT
AAGTTAAGTCTAGAAAAGCGAACTGAAGAACTAAAGGTGGAACAAGAATT
TGCTTCTAAACATCTTTCATCCATTAAATCTAAAGAATTGTCACTAGTGC
TTTATAATAATGAATTTCATAATTTTGAACAAGTTATTACACTTTTCAAG
CGTTGTTTACAATGTACACCAGAACGAGCTATGTCGTACGCAAACATTGT
CGACAGAGATGGCCGATGCATGGCATTGACATCAACCGATCAAAAAGACA
TAGAATCCAAGAAAAATGAAATTTCTGTAAGATCCAAATCTCAAACCATG
ATGGAATTGCTATGCCGAATACATCATCCGTTGATATTGTCTCTTCAGAA
TCTTTTAATTCATATATTAAGGTGGCTGTATGAATTCATTGATAAGTATC
CAAAATTACGGCTACTTCTTTGTACATATCTTTTTTCTGAAAATGAGATG
CAAATTGGGGAAACTTCATTTGAAAAGAGCACTCTAATTCAGGATATATT
TGAGAATCACATTGAAATGTGGAAGTCCGCGAGAAATGTTTGCACTAATT
TTATCATGACTACGATATTCAAGGAAACATATTTCAAAAAACTATTTGTT
GTACAAATGGCACAGAATTACAAAATGATTCTTCATCATTATTCTATTGA
TGATCACAATCCTGAAGATTCTCTTATTTCTTTAAATTGTCAACTATTTA
CTGTTATTAGTTTTGCTAAATATCTATTAGAATCTTATAACTTTATGGAT
GATATAATGAAATTAATTTACAATAAATTAATTGAGTACTCGAAGCCCTT
ACGTCATCAAAACATTGAGAATAGATTGATACTTCATTTTGAAAAGGAAG
AAATGGATGTCAATAAAAAATTTGACCCATTCGAGAGACACATGAGAGCT
TTAAGTGATTTAAAATTTCTTCTAAAAAGTTTGACATCAGCTTACCGTGT
TCATAAAAATCTTGGAGAAACATCGGTTTCTTCCTGTGATAATGGAGCGA
TTTGGCCGGATAACGCCGTGGACAACTTTATGAAATATTTCCAAACATTT
GCCAATTTTTTATCACTTATTCAGGATACTGATACGATTGAAAGAGTTAT
TGAACATCATGTGGAACACGATCCGAATTGGAAAACGGGTGTTGTAATGA
TGTATGATTCCGTGAATTGTATAACACTTACTGCAAAATTGATCGTGTCA
AATAGACAATGTTGGGAGAGAGCGTTTGAAATTCTTCGACAATTTTTTAA
AACCAGAATAGTTGATTTGGAATATAAATATTGCCAAACGTTTAACTTGT
TCTCGTATTCAACTCACGTCATTGAAAATGAGTGGCCTTCTCGATATATA
AGCGTAGTAAAGCCATTACACAGATTTATGGCTGCTCTGCTAATAGATGT
AAAATATCGCAATCAATTAAATGTCACAGAAACTGATTGTTTGTTAGATC
AAACTTTACAAATGTTAGTGTTCTGTAGCCAGCAATCTGGTAACATGTGG
ATTCGTAATGGATCTGTGCCTTATATTTTGACTCAGCAGATCAAATGTTT
AGCTTTGGCTCCAGAAATGTTTGATCGAGATCTTCAATTATTACAATTAA
TGGCTCTTTGTGTACCACCGGAGAGTTTTATACTAAAATGCGTTCATAAG
TTCGATTTACTGGGTTATCTAACGGGCATAGTGGGCAAACAGTCAGATAA
AAAAGCGGTTTTACAAAGAGCTGAGGATTTTTTGCACTCGTTGATTATAT
CTTTGTTTTATCGGCATCGAATTGGAGTTGGTAAAAATGTTACAAAAGAG
GACATTTATGCGCATACAATTCTTCATACTTTGTGTGTTAAATCAATGTC
GCACAGTAAATTGATGAAGAAGCTGTCTGCAAGTTTACAGAAATATCCAA
AAGGAAAATTAATGAACATCATTGATAAAGTCGCTGATCAAACTTTGTCG
TCCCAAGTTGTGATATTCAACGCTAAAAAGTCCTTGATCCTTAGTGATTT
CGATCGATATGTTCCTTATTACTCTCTTCAAGATCGAAATGAAGCAGAAC
TTTCCATTAAAAATTTCTTGAAAAAAGAGGGTCTATCAATGACTATTCAT
CCACCAATTCCGATCGATTTGACTGATGACTGTGCACAATTGCTGAATTA
TATTTCAAATCCGTGCTATACTGAGTTGCTAAATAAATTTCTATATATCT
GTATAACGAAACCGAACGGTGATAACTGGACTGATACTATACTCGATATG
GTTCTATATTTGATTGGATCTTCACTATTGGAGGATATTAAAAATTTAGA
ATTGCCTTTAGAAGAACAGCGACCACTATTTTTTGACGCGTGTATAAACC
AATCTTCTAAAGTAGATATTATTGGTAACTTGGAATTGCTCTGTGACAAA
ATTTCGTGTGATCAACAGTTGGAATTAATTAAATGGATAATTAGAAAATG
CAATGAAATCAAACTCATGAAAAATTCTGGACATGTAAGCACAAGTTTCG
AAGCTATGGAAACGGATAACAATGATTTGGAAAACGTTCAAATATTGAAT
CAGATGAAAATTGCTAAAGCTGATGCTGCGAAAAAGCGACGTGAGTTATT
AATGAGTAAAATGTGGAATATGCAAAAGAAATTTATAAATGAGAATTCTG
AACTATTGACTGAGAAAAAGGATCAACACCCAGTTGCTTGTGATGAAGAT
CATGTCGATTCAAATGTCCACAAAAAACTCGACTTTACTTGTATACTTTG
TCAGGAAAAAAATACCGAAGAAAATAACCGACCAATTGTGCTTATTGCTG
GAGCCTGGCGATCTGCCGTTTTAGCAAAGCATCCATTTATTAGCACCCTT
CCCCCACATATCCAATCATCAAATTCGCAGGATTTAACTACGGTTGATGC
AAATGTAGATCAAAATGAGATGTTTTCGTTTTGGTCGAGTTTGGCTGAAG
AATCAAATCCACATGAAATCGATCGCGGTACAATGAGATCAATCATATCA
ATGTTGGACCACGCGGAGGAAACCTTCATTACGACTTGTGGTCACGTTAT
GCATTACGATTGCAAAACGAGTTACATGAAAGAAATGATGAAGTTGAAAC
AAAATTTCGCAAGGACTAAAGGTGTGCTCTACCCAAGAATCTATAATCGA
TGTCCTTTGTGTAAATGTGTTTGCAACATTGATATTCCAATTATTAAATC
AGACATGTTAAATAAAGTTTCAAACTCAATTTCTTCAATGTCTTTTCAAA
ATTGGATGGAAACTCTCTCTCAATGGATGCCGAATTTCGGTTCAAAAACC
AAGAAATTAGAAATTGCTGTCAGCTGGTGGAGTAAGTTGGGTTCTCATTT
TAACATTCTTATGAAACATGCAACACCAATGAAAACCAGTGATTCTTCGG
CATCTGATGAAGACTTAGTATCATGTTTGGCATCAAGAACAGCATTGGCT
ATTAAATTGCATCCCAGCAAATTAACCAAGGATACTTATAAACATTTCGA
AACAATTAGAAGTAGTTTTTCAGAAAGTTCATCGCAAGAATTGATTGAGC
TCGATTACGCTGTGATGTACACGATATCGGTATGGGATAGGATTATGTTA
GAACATAATACGTCGATTTTGGCCGATATTCCAGAACGACATGCCAATGG
TTTAAGATATTTAATCAACGCAGTCTGTAAAGCACATCAACAATTTGCCA
ATAAAGAAGAAGTCAATCGTGCATGTCAATCTTTTTTCATGCTTTTACAT
CAAATGTTGTTTGATTGTACAAATTTATCTTTCCATAGAGCATGGCTGGA
TTTATATAAATATCAAATTCCCTTGTTTATATTGGAGGTTGATTTCACTT
TTGTCTTAGGATCTCTGTTATTCATGAGATATTCATTAGCGGATTCGAAC
CAATCAGATCCAAATTCCAGGGGAAATGAGATGTTTAATAAGGAGAATTA
CAACTTTTATATAGTAAAATTTATTTATCAGTTTGTGTTTGTACAAGTTC
TATTGTCACTGAAAAATGTCAATATCGAAAACACAGATGTAACTTTGAAG
CAATTGAAAGATCACGATTCTTTAATGTGGTCAGATAAAAATGTTAACGA
ACTTTTCTCTATTCGGGAATCTCTTATTCGACAAGTCGGTGGTAATTGGA
AAATTTCAGATTTAACTCCGGCTGAGGTGGCTGTTGGCTTTTATAAATCA
CTTCTTTCGTTTCTTCGTATTGCAGTGTTTATGCTACATGAGCTCGGATC
AGTTGATATTCCCACTTATTTCAATGTCGATGGAGAATTCATTGAACTAT
TTAGAGTTCTGAAATTGGATTTGATTCCATTTAGTAACTATAGTTATCCT
TCTTGGATAAGCAATCAGCTCAAATTGATCAGTGATTTAAAATTATCAGA
AGCTAAGACATTTTGGAATACACCTTTACCTCATGTGATGCCATTTAACC
CACCAAAGTTGATTGATTTACCAAATGAATTTACAGAAGTTATAACTATG
GGTCTCGATCGAGGCTGTTCTCTGAGTCCACAAGCTTCTGGTACAGTTTC
AGAGATGTCCTTATGCCTGGTTTGTGGAGTTACTGTGTGTCTTACTGGTT
ATTGCTGTCGAAGGATTGATGAGTCGTCTGGCTTCACAATCAGTGGTGCT
CAAATTCACGCCCGGCAATGTCACGAAGGTTATGCATTATTTCTCAACAC
TCGAAACTCAAAGGTTGTGGTTTTATTCTACCAAGCACGTTGGCAAATCT
ATTTGGATCCAATTTATTTGGATAAATTCGGTGAAAGTGATGTTGATCTC
AAACGAGGAAATCCTTTATTTCTCAATCAAGAAGCCTACGCTAAGTTGGA
AAGGAATTGGCTGAATCACAGCATTGGTTGTGTAATCAATGACGGATTTC
TGTCCAATGATTTCTTTGTATAGGAAATTGATGACACCCACCACCACCAT
ATCTCGGTGATCTGCTGCCGTGTCTATATCCGTATTTTCGTGTCACTCGT
GTGCTCATATTCAATGATTTTGTCATACCATTGTCTTTATTTGATATATA
TATATATACATATTTGCCTGATCAGATCTTGGTTTTTGAATTTTCTATCA
TACAATATCGATCCAAACGCGCCTGTTAGAGGAGGAGTCATCGTAATAAT
TTATACACCGCCGGAAAATGTTTCCAATATATTTATTAATTTCAAA

protein sequence of SMED30013828-orf-1

>SMED30013828-orf-1 ID=SMED30013828-orf-1|Name=SMED30013828-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1828bp
MDTNISEMKNFDEKFLDVLCDKSQLLCKPSSSPSPEEEYQSCSDYFESFE
KFIIGRNDKSIIESNVSSSICGKIFKAREPVYICRDCATDDTCVLCRICF
IKSEHTKHNYEMHTSSGGGYCDCGDEEAWKLFSHCNLHGDSLKSSADSTE
EIVYYLEDVPVDVKINFLAISKSIFKYFKNFVMRPLCKLSLEKRTEELKV
EQEFASKHLSSIKSKELSLVLYNNEFHNFEQVITLFKRCLQCTPERAMSY
ANIVDRDGRCMALTSTDQKDIESKKNEISVRSKSQTMMELLCRIHHPLIL
SLQNLLIHILRWLYEFIDKYPKLRLLLCTYLFSENEMQIGETSFEKSTLI
QDIFENHIEMWKSARNVCTNFIMTTIFKETYFKKLFVVQMAQNYKMILHH
YSIDDHNPEDSLISLNCQLFTVISFAKYLLESYNFMDDIMKLIYNKLIEY
SKPLRHQNIENRLILHFEKEEMDVNKKFDPFERHMRALSDLKFLLKSLTS
AYRVHKNLGETSVSSCDNGAIWPDNAVDNFMKYFQTFANFLSLIQDTDTI
ERVIEHHVEHDPNWKTGVVMMYDSVNCITLTAKLIVSNRQCWERAFEILR
QFFKTRIVDLEYKYCQTFNLFSYSTHVIENEWPSRYISVVKPLHRFMAAL
LIDVKYRNQLNVTETDCLLDQTLQMLVFCSQQSGNMWIRNGSVPYILTQQ
IKCLALAPEMFDRDLQLLQLMALCVPPESFILKCVHKFDLLGYLTGIVGK
QSDKKAVLQRAEDFLHSLIISLFYRHRIGVGKNVTKEDIYAHTILHTLCV
KSMSHSKLMKKLSASLQKYPKGKLMNIIDKVADQTLSSQVVIFNAKKSLI
LSDFDRYVPYYSLQDRNEAELSIKNFLKKEGLSMTIHPPIPIDLTDDCAQ
LLNYISNPCYTELLNKFLYICITKPNGDNWTDTILDMVLYLIGSSLLEDI
KNLELPLEEQRPLFFDACINQSSKVDIIGNLELLCDKISCDQQLELIKWI
IRKCNEIKLMKNSGHVSTSFEAMETDNNDLENVQILNQMKIAKADAAKKR
RELLMSKMWNMQKKFINENSELLTEKKDQHPVACDEDHVDSNVHKKLDFT
CILCQEKNTEENNRPIVLIAGAWRSAVLAKHPFISTLPPHIQSSNSQDLT
TVDANVDQNEMFSFWSSLAEESNPHEIDRGTMRSIISMLDHAEETFITTC
GHVMHYDCKTSYMKEMMKLKQNFARTKGVLYPRIYNRCPLCKCVCNIDIP
IIKSDMLNKVSNSISSMSFQNWMETLSQWMPNFGSKTKKLEIAVSWWSKL
GSHFNILMKHATPMKTSDSSASDEDLVSCLASRTALAIKLHPSKLTKDTY
KHFETIRSSFSESSSQELIELDYAVMYTISVWDRIMLEHNTSILADIPER
HANGLRYLINAVCKAHQQFANKEEVNRACQSFFMLLHQMLFDCTNLSFHR
AWLDLYKYQIPLFILEVDFTFVLGSLLFMRYSLADSNQSDPNSRGNEMFN
KENYNFYIVKFIYQFVFVQVLLSLKNVNIENTDVTLKQLKDHDSLMWSDK
NVNELFSIRESLIRQVGGNWKISDLTPAEVAVGFYKSLLSFLRIAVFMLH
ELGSVDIPTYFNVDGEFIELFRVLKLDLIPFSNYSYPSWISNQLKLISDL
KLSEAKTFWNTPLPHVMPFNPPKLIDLPNEFTEVITMGLDRGCSLSPQAS
GTVSEMSLCLVCGVTVCLTGYCCRRIDESSGFTISGAQIHARQCHEGYAL
FLNTRNSKVVVLFYQARWQIYLDPIYLDKFGESDVDLKRGNPLFLNQEAY
AKLERNWLNHSIGCVINDGFLSNDFFV*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination
GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway
GO:0030163	protein catabolic process

Vocabulary: **molecular function**
Term	Definition
GO:0016740	transferase activity
GO:0046872	metal ion binding
GO:0061630	ubiquitin protein ligase activity
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000044	cephalic ganglia
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR039164	UBR1-like
IPR003126	Znf_UBR
IPR013083	Znf_RING/FYVE/PHD
IPR003769	ClpS_core
IPR014719	Ribosomal_L7/12_C/ClpS-like
IPR011528	NERD

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003126	Zinc finger, UBR-type	SMART	SM00396	push_1	coord: 69..139 e-value: 1.7E-24 score: 97.4
IPR003126	Zinc finger, UBR-type	PFAM	PF02207	zf-UBR	coord: 71..138 e-value: 2.2E-19 score: 69.4
IPR003126	Zinc finger, UBR-type	PROSITE	PS51157	ZF_UBR	coord: 69..140 score: 10.39
IPR003769	Adaptor protein ClpS, core	PFAM	PF02617	ClpS	coord: 218..286 e-value: 4.2E-13 score: 48.9
None	No IPR available	GENE3D	G3DSA:2.10.110.30		coord: 71..140 e-value: 3.2E-23 score: 83.5
IPR039164	E3 ubiquitin-protein ligase UBR1-like	PANTHER	PTHR21497	UBIQUITIN LIGASE E3 ALPHA-RELATED	coord: 32..1812
IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like	SUPERFAMILY	SSF54736	ClpS-like	coord: 219..265

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E3 ubiquitin-protein ligase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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