E3 ubiquitin-protein ligase

Overview
NameE3 ubiquitin-protein ligase
Smed IDSMED30013730
Length (bp)2911
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of E3 ubiquitin-protein ligase (SMED30013730) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase (SMED30013730) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase (SMED30013730) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase (SMED30013730) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013730

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30013730h1SMcG0018042 dd_Smed_v4_7779_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30013730h1SMcG0018042 dd_Smed_v4_7779_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
central nervous systemSMED30013730h1SMcG0018042 GAKN01002039.1SmedAsxl_pearson_GAKN01PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30013730h1SMcG0018042 HO006936.1smed_ncbi_20240424PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
ventral nerve cordSMED30013730h1SMcG0018042 HO006936.1smed_ncbi_20240424PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30013730h1SMcG0018042 HO006936.1smed_ncbi_20240424PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: WWP2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804])

HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0
Identity = 388/820 (47.32%), Postives = 518/820 (63.17%), Query Frame = 1 
Query:  232 WSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNM---------------LQNYCNMELILKFT------VTAWPIKPLTKN------------------NASKRSSLIIGQGTSNSEFHDVE-------TAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTA---LPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNE------WDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            W++  + N  + S +++ +   H    T  N ++   ++ L N+L+  GGK++N  + + L+  N+   +               L N  N   +   +       +   + P  ++                   AS R++   G+ +  +     +       + +++ T+++  T  T  +    V   +  +   + +     +  P  + P    E S++    LP  +   + LP  +E R   + R+YY+D  TKT++WE+P  +P GWE+R D  GR YYVDHNTR+TTWQRP A  + N   WQ  R++    MQ    R LY + +A          TD D L PLP GWE+R D N RVYYVNH  RTTQWEDPR QG    P LP GWE++Y  +G  +F+DHNT+ +T+ DPR   +   +      +D S   K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRMLNK+P L+D+E++D  +YNS+ +IKE +L EC LELYF  D EILGK+ T ELK GG SI VTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV PL WL YFDEKE+EL+LCGMQ+I++ DW+K T+YRHYT+NSKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCI+KVGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:   67 WNEIIILNVTAQSHLDLKVWSCH----TLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSA---------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: ITCH (itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890])

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 354/642 (55.14%), Postives = 463/642 (72.12%), Query Frame = 1 
Query:  655 TVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTAL-------------PINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +VN   + + E++ S        PP +   N SE +++ L             P+N V   PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ ECDLE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHY + SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  269 SVNGSPSATSESDGSS---TGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 903
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: ITCH (itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890])

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 354/642 (55.14%), Postives = 463/642 (72.12%), Query Frame = 1 
Query:  655 TVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTAL-------------PINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +VN   + + E++ S        PP +   N SE +++ L             P+N V   PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ ECDLE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHY + SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  269 SVNGSPSATSESDGSS---TGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 903
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: ITCH (itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890])

HSP 1 Score: 754.977 bits (1948), Expect = 0.000e+0
Identity = 350/619 (56.54%), Postives = 454/619 (73.34%), Query Frame = 1 
Query:  724 PPESEPCNVSECSSTAL-------------PINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            PP +   N SE +++ L             P+N V   PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ ECDLE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHY + SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  286 PPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 900
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Match: ITCH (itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890])

HSP 1 Score: 754.977 bits (1948), Expect = 0.000e+0
Identity = 350/619 (56.54%), Postives = 454/619 (73.34%), Query Frame = 1 
Query:  724 PPESEPCNVSECSSTAL-------------PINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            PP +   N SE +++ L             P+N V   PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ ECDLE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHY + SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  248 PPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 732.635 bits (1890), Expect = 0.000e+0
Identity = 353/585 (60.34%), Postives = 434/585 (74.19%), Query Frame = 1 
Query:  793 DEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKP--QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDAN-NRVYYVNHENRTTQWEDPRYQG---PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFS 2499
            +E LP  +EMR  +  R YY+D  TK+++WE+P  QP+P GWE R D  GRVYYVDHNTR+TTWQRP A+ML      ++W+S R+  M +   R     N        NF  D D L PLP GWE+R D N +R+Y+VNH NRTTQWEDPR QG    PLPDGWE+R+   G PFFIDH +K +TY DPR            +++  E     KIA FR+LC SN V  H+KI VSR ++  DSF +IM+     LR+RLYI F+GEEGLDYGGVAREWFF LS E+LNPM CLF YA +NNYSL+INPASFVNP+HL+YF ++GRFIAMALFHGKFI SGFT+ FYK+MLNKK +L+DIE VD   YNSL +IK+ +++ECD+ELYF AD+E+LG+L+T ELK GG  I VTE+NK EYI+L+V WRFNRG+E Q ++F  GFN V PL W+ YFDE+E+ELLLCGMQD++VDDW+++TVYRHY   SKQ+  FW++VR+L  E R RLLQFVTGTCR+P+GGF  LMGS GPQ FCIE+VGKE WLPRSHTCFNRLDLPPY+S+ QL EKL+ AI+ TEGF 
Sbjct:  218 EEQLPDGWEMRFDQYGRKYYVDHTTKSTTWERPSTQPLPQGWEMRRDPRGRVYYVDHNTRTTTWQRPTADML---EAHEQWQSGRDQAMLQWEQRFLLQQN--------NFSAD-DPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFG 790
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 731.48 bits (1887), Expect = 0.000e+0
Identity = 353/587 (60.14%), Postives = 434/587 (73.94%), Query Frame = 1 
Query:  793 DEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKP--QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDAN-NRVYYVNHENRTTQWEDPRYQG-----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFS 2499
            +E LP  +EMR  +  R YY+D  TK+++WE+P  QP+P GWE R D  GRVYYVDHNTR+TTWQRP A+ML      ++W+S R+  M +   R     N        NF  D D L PLP GWE+R D N +R+Y+VNH NRTTQWEDPR QG      PLPDGWE+R+   G PFFIDH +K +TY DPR            +++  E     KIA FR+LC SN V  H+KI VSR ++  DSF +IM+     LR+RLYI F+GEEGLDYGGVAREWFF LS E+LNPM CLF YA +NNYSL+INPASFVNP+HL+YF ++GRFIAMALFHGKFI SGFT+ FYK+MLNKK +L+DIE VD   YNSL +IK+ +++ECD+ELYF AD+E+LG+L+T ELK GG  I VTE+NK EYI+L+V WRFNRG+E Q ++F  GFN V PL W+ YFDE+E+ELLLCGMQD++VDDW+++TVYRHY   SKQ+  FW++VR+L  E R RLLQFVTGTCR+P+GGF  LMGS GPQ FCIE+VGKE WLPRSHTCFNRLDLPPY+S+ QL EKL+ AI+ TEGF 
Sbjct:  218 EEQLPDGWEMRFDQYGRKYYVDHTTKSTTWERPSTQPLPQGWEMRRDPRGRVYYVDHNTRTTTWQRPTADML---EAHEQWQSGRDQAMLQWEQRFLLQQN--------NFSAD-DPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFG 792
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 641.343 bits (1653), Expect = 0.000e+0
Identity = 310/507 (61.14%), Postives = 380/507 (74.95%), Query Frame = 1 
Query: 1021 QEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDAN-NRVYYVNHENRTTQWEDPRYQG---PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFS 2499
            ++W+S R+  M +   R     N        NF  D D L PLP GWE+R D N +R+Y+VNH NRTTQWEDPR QG    PLPDGWE+R+   G PFFIDH +K +TY DPR            +++  E     KIA FR+LC SN V  H+KI VSR ++  DSF +IM+     LR+RLYI F+GEEGLDYGGVAREWFF LS E+LNPM CLF YA +NNYSL+INPASFVNP+HL+YF ++GRFIAMALFHGKFI SGFT+ FYK+MLNKK +L+DIE VD   YNSL +IK+ +++ECD+ELYF AD+E+LG+L+T ELK GG  I VTE+NK EYI+L+V WRFNRG+E Q ++F  GFN V PL W+ YFDE+E+ELLLCGMQD++VDDW+++TVYRHY   SKQ+  FW++VR+L  E R RLLQFVTGTCR+P+GGF  LMGS GPQ FCIE+VGKE WLPRSHTCFNRLDLPPY+S+ QL EKL+ AI+ TEGF 
Sbjct:    6 EQWQSGRDQAMLQWEQRFLLQQN--------NFSAD-DPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFG 503

HSP 2 Score: 57.3806 bits (137), Expect = 4.129e-8
Identity = 24/71 (33.80%), Postives = 44/71 (61.97%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKD-NRIYYIDRLTKTSSWEKP-------QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP 987
            PLP+ +E R+  + +R+Y+++ + +T+ WE P       QP+P GWE R    G  +++DH +++TT+  P
Sbjct:   38 PLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDP 108
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 641.343 bits (1653), Expect = 0.000e+0
Identity = 310/507 (61.14%), Postives = 380/507 (74.95%), Query Frame = 1 
Query: 1021 QEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDAN-NRVYYVNHENRTTQWEDPRYQG---PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFS 2499
            ++W+S R+  M +   R     N        NF  D D L PLP GWE+R D N +R+Y+VNH NRTTQWEDPR QG    PLPDGWE+R+   G PFFIDH +K +TY DPR            +++  E     KIA FR+LC SN V  H+KI VSR ++  DSF +IM+     LR+RLYI F+GEEGLDYGGVAREWFF LS E+LNPM CLF YA +NNYSL+INPASFVNP+HL+YF ++GRFIAMALFHGKFI SGFT+ FYK+MLNKK +L+DIE VD   YNSL +IK+ +++ECD+ELYF AD+E+LG+L+T ELK GG  I VTE+NK EYI+L+V WRFNRG+E Q ++F  GFN V PL W+ YFDE+E+ELLLCGMQD++VDDW+++TVYRHY   SKQ+  FW++VR+L  E R RLLQFVTGTCR+P+GGF  LMGS GPQ FCIE+VGKE WLPRSHTCFNRLDLPPY+S+ QL EKL+ AI+ TEGF 
Sbjct:    6 EQWQSGRDQAMLQWEQRFLLQQN--------NFSAD-DPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFG 503

HSP 2 Score: 57.3806 bits (137), Expect = 4.129e-8
Identity = 24/71 (33.80%), Postives = 44/71 (61.97%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKD-NRIYYIDRLTKTSSWEKP-------QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP 987
            PLP+ +E R+  + +R+Y+++ + +T+ WE P       QP+P GWE R    G  +++DH +++TT+  P
Sbjct:   38 PLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDP 108
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 640.573 bits (1651), Expect = 0.000e+0
Identity = 310/509 (60.90%), Postives = 380/509 (74.66%), Query Frame = 1 
Query: 1021 QEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDAN-NRVYYVNHENRTTQWEDPRYQG-----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFS 2499
            ++W+S R+  M +   R     N        NF  D D L PLP GWE+R D N +R+Y+VNH NRTTQWEDPR QG      PLPDGWE+R+   G PFFIDH +K +TY DPR            +++  E     KIA FR+LC SN V  H+KI VSR ++  DSF +IM+     LR+RLYI F+GEEGLDYGGVAREWFF LS E+LNPM CLF YA +NNYSL+INPASFVNP+HL+YF ++GRFIAMALFHGKFI SGFT+ FYK+MLNKK +L+DIE VD   YNSL +IK+ +++ECD+ELYF AD+E+LG+L+T ELK GG  I VTE+NK EYI+L+V WRFNRG+E Q ++F  GFN V PL W+ YFDE+E+ELLLCGMQD++VDDW+++TVYRHY   SKQ+  FW++VR+L  E R RLLQFVTGTCR+P+GGF  LMGS GPQ FCIE+VGKE WLPRSHTCFNRLDLPPY+S+ QL EKL+ AI+ TEGF 
Sbjct:    6 EQWQSGRDQAMLQWEQRFLLQQN--------NFSAD-DPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFG 505

HSP 2 Score: 56.6102 bits (135), Expect = 6.891e-8
Identity = 24/73 (32.88%), Postives = 44/73 (60.27%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKD-NRIYYIDRLTKTSSWEKP---------QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP 987
            PLP+ +E R+  + +R+Y+++ + +T+ WE P         QP+P GWE R    G  +++DH +++TT+  P
Sbjct:   38 PLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDP 110
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Su(dx) (gene:FBgn0003557 transcript:FBtr0077823)

HSP 1 Score: 750.355 bits (1936), Expect = 0.000e+0
Identity = 351/606 (57.92%), Postives = 449/606 (74.09%), Query Frame = 1 
Query:  748 VSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATN--FQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGP--------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRK--------FMKVDNEWDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VS+ +   L     +DEPLP  +E+R  +  R YY+D  T+++ WEKP P+P GWE R DG GRVYYVDHNTR TTWQRPN+  L +   +Q W+ +R + + +   R   +     P   T    Q D D L PLP GWE+++ ++NRVY+VNH+NRTTQWEDPR QG         PLP GWEIRY   G+ FF+DHNT+ +T+ DPR            V   ++ S   K++ FR+LCQSN +  HIKI V+R+ L  DS++QIM++    LR+RLYI F+GEEGLDYGGV+REWFF LS E+LNPM CLFEYA  NNYSL+INPAS+VNP+HLQYF+F+GRFIAMAL+HG+FI SGFT+ FYKRMLNKK  ++DIE +D  +YNSL ++K+ +++EC LEL+FS DFE+LG++   ELK  G    VTE+NKEEYI LM  WR  RGIE Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQD++V+DW+++T+YRHY +NSKQ++ FW++VR   NE R RLLQFVTGTCR+P+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPYKS+ QL EKL +AI+ETEGF  +
Sbjct:  347 VSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH---FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Su(dx) (gene:FBgn0003557 transcript:FBtr0077824)

HSP 1 Score: 750.355 bits (1936), Expect = 0.000e+0
Identity = 351/606 (57.92%), Postives = 449/606 (74.09%), Query Frame = 1 
Query:  748 VSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATN--FQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGP--------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRK--------FMKVDNEWDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VS+ +   L     +DEPLP  +E+R  +  R YY+D  T+++ WEKP P+P GWE R DG GRVYYVDHNTR TTWQRPN+  L +   +Q W+ +R + + +   R   +     P   T    Q D D L PLP GWE+++ ++NRVY+VNH+NRTTQWEDPR QG         PLP GWEIRY   G+ FF+DHNT+ +T+ DPR            V   ++ S   K++ FR+LCQSN +  HIKI V+R+ L  DS++QIM++    LR+RLYI F+GEEGLDYGGV+REWFF LS E+LNPM CLFEYA  NNYSL+INPAS+VNP+HLQYF+F+GRFIAMAL+HG+FI SGFT+ FYKRMLNKK  ++DIE +D  +YNSL ++K+ +++EC LEL+FS DFE+LG++   ELK  G    VTE+NKEEYI LM  WR  RGIE Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQD++V+DW+++T+YRHY +NSKQ++ FW++VR   NE R RLLQFVTGTCR+P+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPYKS+ QL EKL +AI+ETEGF  +
Sbjct:  347 VSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH---FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Su(dx) (gene:FBgn0003557 transcript:FBtr0339529)

HSP 1 Score: 750.355 bits (1936), Expect = 0.000e+0
Identity = 351/606 (57.92%), Postives = 449/606 (74.09%), Query Frame = 1 
Query:  748 VSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATN--FQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGP--------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRK--------FMKVDNEWDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VS+ +   L     +DEPLP  +E+R  +  R YY+D  T+++ WEKP P+P GWE R DG GRVYYVDHNTR TTWQRPN+  L +   +Q W+ +R + + +   R   +     P   T    Q D D L PLP GWE+++ ++NRVY+VNH+NRTTQWEDPR QG         PLP GWEIRY   G+ FF+DHNT+ +T+ DPR            V   ++ S   K++ FR+LCQSN +  HIKI V+R+ L  DS++QIM++    LR+RLYI F+GEEGLDYGGV+REWFF LS E+LNPM CLFEYA  NNYSL+INPAS+VNP+HLQYF+F+GRFIAMAL+HG+FI SGFT+ FYKRMLNKK  ++DIE +D  +YNSL ++K+ +++EC LEL+FS DFE+LG++   ELK  G    VTE+NKEEYI LM  WR  RGIE Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQD++V+DW+++T+YRHY +NSKQ++ FW++VR   NE R RLLQFVTGTCR+P+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPYKS+ QL EKL +AI+ETEGF  +
Sbjct:  347 VSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH---FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Su(dx) (gene:FBgn0003557 transcript:FBtr0077822)

HSP 1 Score: 750.355 bits (1936), Expect = 0.000e+0
Identity = 351/606 (57.92%), Postives = 449/606 (74.09%), Query Frame = 1 
Query:  748 VSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATN--FQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGP--------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRK--------FMKVDNEWDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VS+ +   L     +DEPLP  +E+R  +  R YY+D  T+++ WEKP P+P GWE R DG GRVYYVDHNTR TTWQRPN+  L +   +Q W+ +R + + +   R   +     P   T    Q D D L PLP GWE+++ ++NRVY+VNH+NRTTQWEDPR QG         PLP GWEIRY   G+ FF+DHNT+ +T+ DPR            V   ++ S   K++ FR+LCQSN +  HIKI V+R+ L  DS++QIM++    LR+RLYI F+GEEGLDYGGV+REWFF LS E+LNPM CLFEYA  NNYSL+INPAS+VNP+HLQYF+F+GRFIAMAL+HG+FI SGFT+ FYKRMLNKK  ++DIE +D  +YNSL ++K+ +++EC LEL+FS DFE+LG++   ELK  G    VTE+NKEEYI LM  WR  RGIE Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQD++V+DW+++T+YRHY +NSKQ++ FW++VR   NE R RLLQFVTGTCR+P+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPYKS+ QL EKL +AI+ETEGF  +
Sbjct:  347 VSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH---FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Match: Su(dx) (gene:FBgn0003557 transcript:FBtr0334778)

HSP 1 Score: 750.355 bits (1936), Expect = 0.000e+0
Identity = 351/606 (57.92%), Postives = 449/606 (74.09%), Query Frame = 1 
Query:  748 VSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATN--FQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGP--------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRK--------FMKVDNEWDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VS+ +   L     +DEPLP  +E+R  +  R YY+D  T+++ WEKP P+P GWE R DG GRVYYVDHNTR TTWQRPN+  L +   +Q W+ +R + + +   R   +     P   T    Q D D L PLP GWE+++ ++NRVY+VNH+NRTTQWEDPR QG         PLP GWEIRY   G+ FF+DHNT+ +T+ DPR            V   ++ S   K++ FR+LCQSN +  HIKI V+R+ L  DS++QIM++    LR+RLYI F+GEEGLDYGGV+REWFF LS E+LNPM CLFEYA  NNYSL+INPAS+VNP+HLQYF+F+GRFIAMAL+HG+FI SGFT+ FYKRMLNKK  ++DIE +D  +YNSL ++K+ +++EC LEL+FS DFE+LG++   ELK  G    VTE+NKEEYI LM  WR  RGIE Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQD++V+DW+++T+YRHY +NSKQ++ FW++VR   NE R RLLQFVTGTCR+P+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPYKS+ QL EKL +AI+ETEGF  +
Sbjct:  347 VSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH---FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 761.525 bits (1965), Expect = 0.000e+0
Identity = 354/607 (58.32%), Postives = 451/607 (74.30%), Query Frame = 1 
Query:  721 PPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P   S P       +   P   V  EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM  +P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LK  G ++ VTE+NKEEYI LM  WRF+RG+E+Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  308 PAAPSTPAPDGGKPAQQQPTGGV--EPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 903
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 760.37 bits (1962), Expect = 0.000e+0
Identity = 354/607 (58.32%), Postives = 451/607 (74.30%), Query Frame = 1 
Query:  721 PPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P   S P       +   P   V  EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM  +P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LK  G ++ VTE+NKEEYI LM  WRF+RG+E+Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  225 PAAPSTPAPDGGKPAQQQPTGGV--EPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 820
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 757.288 bits (1954), Expect = 0.000e+0
Identity = 354/607 (58.32%), Postives = 451/607 (74.30%), Query Frame = 1 
Query:  721 PPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P   S P       +   P   V  EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM  +P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LK  G ++ VTE+NKEEYI LM  WRF+RG+E+Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  210 PAAPSTPAPDGGKPAQQQPTGGV--EPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 805
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 752.666 bits (1942), Expect = 0.000e+0
Identity = 345/576 (59.90%), Postives = 441/576 (76.56%), Query Frame = 1 
Query:  814 YEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM  +P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LK  G ++ VTE+NKEEYI LM  WRF+RG+E+Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  291 WEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 857

HSP 2 Score: 68.1662 bits (165), Expect = 4.224e-11
Identity = 29/64 (45.31%), Postives = 42/64 (65.62%), Query Frame = 1 
Query: 1153 IGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDP 1344
            + WE+R D + R YYV+H  RTT WE P+    PLP GWE R +  G+ +++DHNT+ +T+  P
Sbjct:  289 LSWEQRKDPHGRTYYVDHNTRTTTWERPQ----PLPLGWERRVDNRGRIYYVDHNTRTTTWQRP 348

HSP 3 Score: 65.0846 bits (157), Expect = 4.011e-10
Identity = 39/111 (35.14%), Postives = 57/111 (51.35%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQ--------PIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRV 1107
            PLP  +E R   ++R+Y+++  TKT+ WE P+        P+P GWE R    G  Y+VDHNTR+TT+  P     + V+   +   ER+   + A  R     NAL   V
Sbjct:  393 PLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGK-SAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHV 502
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 752.666 bits (1942), Expect = 0.000e+0
Identity = 345/576 (59.90%), Postives = 441/576 (76.56%), Query Frame = 1 
Query:  814 YEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM  +P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LK  G ++ VTE+NKEEYI LM  WRF+RG+E+Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  307 WEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 873

HSP 2 Score: 67.781 bits (164), Expect = 5.228e-11
Identity = 29/64 (45.31%), Postives = 42/64 (65.62%), Query Frame = 1 
Query: 1153 IGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDP 1344
            + WE+R D + R YYV+H  RTT WE P+    PLP GWE R +  G+ +++DHNT+ +T+  P
Sbjct:  305 LSWEQRKDPHGRTYYVDHNTRTTTWERPQ----PLPLGWERRVDNRGRIYYVDHNTRTTTWQRP 364

HSP 3 Score: 64.3142 bits (155), Expect = 6.685e-10
Identity = 39/111 (35.14%), Postives = 57/111 (51.35%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQ--------PIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRV 1107
            PLP  +E R   ++R+Y+++  TKT+ WE P+        P+P GWE R    G  Y+VDHNTR+TT+  P     + V+   +   ER+   + A  R     NAL   V
Sbjct:  409 PLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGK-SAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHV 518
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100038255])

HSP 1 Score: 778.859 bits (2010), Expect = 0.000e+0
Identity = 390/844 (46.21%), Postives = 531/844 (62.91%), Query Frame = 1 
Query:   85 DFSIKLHFNVVKLKNLKILFNHKPSFFLDITLDNSQNHITSKKQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLK--------KSNELQNMLQNY-CNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTA--------------ISIENNFSKLIQNSQPPPESEPCNVSECSSTALPIN---SVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            D  + +  +  KLK  K  F    + + ++ +D           S  P W +    +    + +   +   H       ++++    + LK  L+    KL+     + L         ++ EL  +L       E +  F  TA P   L  ++  + SS    +  S      + +     +    + +++ S    ++  D+               +   ++       S  P  ++P   S   S   P+    S   EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D L PLP GWERRVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNTK +T+ DPR      K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC+LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFN V+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:   16 DLQLHVTVSCAKLKRKKNWFGT--TVYTELAVDGETKKTAKSSSSSNPKWEERLTVSVTPQTTLEFKVWSHHSWKA---DALLGKTAVDLKQALETHNRKLERVKEQLKLSLDGKHGTVQTGELTVILDGLNVEPESLATFNSTATPASKLHVHSLQQESSFATSEANSTPSHEALPSPAGAPSSDSIEMMDSTSDGPVSIPLDSGTSAESSSAGASSEPVRAADSGPSPAAGSNSPDAAKPRQASSTGS-GDPVRQQPSSAAEPLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKVTSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 844
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100038255])

HSP 1 Score: 773.081 bits (1995), Expect = 0.000e+0
Identity = 359/613 (58.56%), Postives = 458/613 (74.71%), Query Frame = 1 
Query:  712 NSQPPPESEPCNVSECSSTALPIN---SVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             S  P  ++P   S   S   P+    S   EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D L PLP GWERRVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNTK +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC+LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFN V+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  312 GSNSPDAAKPRQASSTGS-GDPVRQQPSSAAEPLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVSKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKVTSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 914
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100038255])

HSP 1 Score: 771.926 bits (1992), Expect = 0.000e+0
Identity = 379/766 (49.48%), Postives = 507/766 (66.19%), Query Frame = 1 
Query:  322 NSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLK--------KSNELQNMLQNY-CNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTA--------------ISIENNFSKLIQNSQPPPESEPCNVSECSSTALPIN---SVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            ++++    + LK  L+    KL+     + L         ++ EL  +L       E +  F  TA P   L  ++  + SS    +  S      + +     +    + +++ S    ++  D+               +   ++       S  P  ++P   S   S   P+    S   EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D L PLP GWERRVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNTK +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC+LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFN V+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:   59 DALLGKTAVDLKQALETHNRKLERVKEQLKLSLDGKHGTVQTGELTVILDGLNVEPESLATFNSTATPASKLHVHSLQQESSFATSEANSTPSHEALPSPAGAPSSDSIEMMDSTSDGPVSIPLDSGTSAESSSAGASSEPVRAADSGPSPAAGSNSPDAAKPRQASSTGS-GDPVRQQPSSAAEPLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVSKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKVTSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 814
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100038255])

HSP 1 Score: 771.926 bits (1992), Expect = 0.000e+0
Identity = 394/846 (46.57%), Postives = 532/846 (62.88%), Query Frame = 1 
Query:  109 NVVKLKNLKILFNHKPSFFLDITLDNSQNHITSKKQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLK--------KSNELQNMLQNY-CNMELILKFTVTAWPIKPLTKNNASKRSS-------LIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASR-----TVNSDTA------------ISIENNFSKLIQNSQPPPESEPCNVSECSSTALPIN---SVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +  KLK  K  F    + + ++ +D           S  P W +    +    + +   +   H       ++++    + LK  L+    KL+     + L         ++ EL  +L       E +  F  TA P + + +N  + R +         +G  +  +     E   S       D+IE +   S       ++S T+            +   ++       S  P  ++P   S   S   P+    S   EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D L PLP GWERRVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNTK +T+ DPR      K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC+LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFN V+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:    9 SCAKLKRKKNWFGT--TVYTELAVDGETKKTAKSSSSSNPKWEERLTVSVTPQTTLEFKVWSHHSWKA---DALLGKTAVDLKQALETHNRKLERVKEQLKLSLDGKHGTVQTGELTVILDGLNVEPESLATFNSTATPAREIQQNGDAVRENGGETSLEARVGATSEANSTPSHEALPSPAGAPSSDSIEMMDSTSDGPVSIPLDSGTSAESSSAGASSEPVRAADSGPSPAAGSNSPDAAKPRQASSTGS-GDPVRQQPSSAAEPLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKVTSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 839
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:100038255])

HSP 1 Score: 763.451 bits (1970), Expect = 0.000e+0
Identity = 349/579 (60.28%), Postives = 446/579 (77.03%), Query Frame = 1 
Query:  805 PQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P+ +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D L PLP GWERRVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNTK +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC+LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFN V+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  244 PRIWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVSKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKVTSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 813
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1861728])

HSP 1 Score: 760.755 bits (1963), Expect = 0.000e+0
Identity = 348/586 (59.39%), Postives = 446/586 (76.11%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM--------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             N E LP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D   PLP GWE+RVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR           ++  E     K+A FR+LCQSN +  H+KINVSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC LE+YFS D EILGK+ + +LK GG +ILVTE+NK+EYI LM  WRF+RG++ Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+   NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  342 TNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 918

HSP 2 Score: 78.1814 bits (191), Expect = 4.366e-14
Identity = 40/102 (39.22%), Postives = 58/102 (56.86%), Query Frame = 1 
Query: 1039 RNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDP 1344
            RNN++ +   +  G    L P      Q+ +   E LP GWE+R D + R YYV+H  RTT WE P+    PLP GWE R +  G+ +++DHNT+ +T+  P
Sbjct:  317 RNNSVFDKVRQPEGCVEPLRP------QSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ----PLPPGWERRVDDRGRVYYVDHNTRTTTWQRP 408
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1861728])

HSP 1 Score: 760.755 bits (1963), Expect = 0.000e+0
Identity = 348/586 (59.39%), Postives = 446/586 (76.11%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM--------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             N E LP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D   PLP GWE+RVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR           ++  E     K+A FR+LCQSN +  H+KINVSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC LE+YFS D EILGK+ + +LK GG +ILVTE+NK+EYI LM  WRF+RG++ Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+   NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  342 TNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 918

HSP 2 Score: 78.1814 bits (191), Expect = 4.366e-14
Identity = 40/102 (39.22%), Postives = 58/102 (56.86%), Query Frame = 1 
Query: 1039 RNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDP 1344
            RNN++ +   +  G    L P      Q+ +   E LP GWE+R D + R YYV+H  RTT WE P+    PLP GWE R +  G+ +++DHNT+ +T+  P
Sbjct:  317 RNNSVFDKVRQPEGCVEPLRP------QSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ----PLPPGWERRVDDRGRVYYVDHNTRTTTWQRP 408
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1914144])

HSP 1 Score: 758.829 bits (1958), Expect = 0.000e+0
Identity = 386/786 (49.11%), Postives = 511/786 (65.01%), Query Frame = 1 
Query:  232 WSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKL------DNTYMAVVLK------KSNELQNMLQNYCNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTA---LPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNE------WDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            W++  V N  + S +++ +   H    T  N ++   ++ L N+L+  GGK       +++  A+  +       +N      + + +     +    A    P  +N   +        G +N   ++  T  S+   S    + +L  A+ +V+S+       N + L      P +S P    E S++    LP  +   + LP  +E R   + R+YY+D  TKT++WE+P  +P GWE+R D  GR YYVDHNTR+TTWQRP A  + N   WQ  R++    MQ    R LY + +A          TD D L PLP GWE+R D N RVYYVNH  RTTQWEDPR QG    P LP GWE++Y  +G  +F+DHNT+ +T+ DPR   +   +      +D S   K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRMLNK+P L+D+E++D  +YNS+ +IKE +L EC LEL+F  D EILGK+ T ELK GG +I VTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV PL WL YFDEKE+EL+LCGMQ+I++ DW+K+ +YRHYT++SKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCI++VGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:   67 WNEIIVLNVTAQSHLDLKVWSCH----TLRNELLGTASVNLSNVLKNNGGKRSQPPSRESSGTAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAASEQSPGARNRHRQPVKNSSSSGLANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNP------NTTSL------PAQSTPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSA---------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 824
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1914144])

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 363/655 (55.42%), Postives = 464/655 (70.84%), Query Frame = 1 
Query:  589 TAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTA---LPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNE------WDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            + +++ T++E  T  +  + S  V   +  +   + S     +  P +S P    E S++    LP  +   + LP  +E R   + R+YY+D  TKT++WE+P  +P GWE+R D  GR YYVDHNTR+TTWQRP A  + N   WQ  R++    MQ    R LY + +A          TD D L PLP GWE+R D N RVYYVNH  RTTQWEDPR QG    P LP GWE++Y  +G  +F+DHNT+ +T+ DPR   +   +      +D S   K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRMLNK+P L+D+E++D  +YNS+ +IKE +L EC LEL+F  D EILGK+ T ELK GG +I VTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV PL WL YFDEKE+EL+LCGMQ+I++ DW+K+ +YRHYT++SKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCI++VGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:  228 SGLANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSA---------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 870
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Match: Itch (itchy, E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1202301])

HSP 1 Score: 751.895 bits (1940), Expect = 0.000e+0
Identity = 347/601 (57.74%), Postives = 450/601 (74.88%), Query Frame = 1 
Query:  739 PCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P  +S   S   P+N+V+  PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ EC LE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHYT+ SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  269 PLTIS-GGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRATTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 864
[Close]
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q8BZZ3|WWP1_MOUSE (NEDD4-like E3 ubiquitin-protein ligase WWP1 OS=Mus musculus OX=10090 GN=Wwp1 PE=1 SV=2)

HSP 1 Score: 760.755 bits (1963), Expect = 0.000e+0
Identity = 348/586 (59.39%), Postives = 446/586 (76.11%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM--------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             N E LP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY          A+    ++D   PLP GWE+RVD+ +RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR           ++  E     K+A FR+LCQSN +  H+KINVSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRML+KK  ++D+E++D  +YNSL +I++ ++ EC LE+YFS D EILGK+ + +LK GG +ILVTE+NK+EYI LM  WRF+RG++ Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+   NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  342 TNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS---------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 918

HSP 2 Score: 78.1814 bits (191), Expect = 3.054e-13
Identity = 40/102 (39.22%), Postives = 58/102 (56.86%), Query Frame = 1 
Query: 1039 RNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDP 1344
            RNN++ +   +  G    L P      Q+ +   E LP GWE+R D + R YYV+H  RTT WE P+    PLP GWE R +  G+ +++DHNT+ +T+  P
Sbjct:  317 RNNSVFDKVRQPEGCVEPLRP------QSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ----PLPPGWERRVDDRGRVYYVDHNTRTTTWQRP 408
[Close]
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|O00308|WWP2_HUMAN (NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2)

HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0
Identity = 388/820 (47.32%), Postives = 518/820 (63.17%), Query Frame = 1 
Query:  232 WSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNM---------------LQNYCNMELILKFT------VTAWPIKPLTKN------------------NASKRSSLIIGQGTSNSEFHDVE-------TAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTA---LPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNE------WDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            W++  + N  + S +++ +   H    T  N ++   ++ L N+L+  GGK++N  + + L+  N+   +               L N  N   +   +       +   + P  ++                   AS R++   G+ +  +     +       + +++ T+++  T  T  +    V   +  +   + +     +  P  + P    E S++    LP  +   + LP  +E R   + R+YY+D  TKT++WE+P  +P GWE+R D  GR YYVDHNTR+TTWQRP A  + N   WQ  R++    MQ    R LY + +A          TD D L PLP GWE+R D N RVYYVNH  RTTQWEDPR QG    P LP GWE++Y  +G  +F+DHNT+ +T+ DPR   +   +      +D S   K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRMLNK+P L+D+E++D  +YNS+ +IKE +L EC LELYF  D EILGK+ T ELK GG SI VTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV PL WL YFDEKE+EL+LCGMQ+I++ DW+K T+YRHYT+NSKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCI+KVGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:   67 WNEIIILNVTAQSHLDLKVWSCH----TLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSA---------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
[Close]
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q9DBH0|WWP2_MOUSE (NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Mus musculus OX=10090 GN=Wwp2 PE=1 SV=1)

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 363/655 (55.42%), Postives = 464/655 (70.84%), Query Frame = 1 
Query:  589 TAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTA---LPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNE------WDLSA--KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            + +++ T++E  T  +  + S  V   +  +   + S     +  P +S P    E S++    LP  +   + LP  +E R   + R+YY+D  TKT++WE+P  +P GWE+R D  GR YYVDHNTR+TTWQRP A  + N   WQ  R++    MQ    R LY + +A          TD D L PLP GWE+R D N RVYYVNH  RTTQWEDPR QG    P LP GWE++Y  +G  +F+DHNT+ +T+ DPR   +   +      +D S   K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRMLNK+P L+D+E++D  +YNS+ +IKE +L EC LEL+F  D EILGK+ T ELK GG +I VTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV PL WL YFDEKE+EL+LCGMQ+I++ DW+K+ +YRHYT++SKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCI++VGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:  228 SGLANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSA---------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 870
[Close]
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q96J02|ITCH_HUMAN (E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2)

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 354/642 (55.14%), Postives = 463/642 (72.12%), Query Frame = 1 
Query:  655 TVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTAL-------------PINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +VN   + + E++ S        PP +   N SE +++ L             P+N V   PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ ECDLE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHY + SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  269 SVNGSPSATSESDGSS---TGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 903
[Close]
BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Match: sp|Q8C863|ITCH_MOUSE (E3 ubiquitin-protein ligase Itchy OS=Mus musculus OX=10090 GN=Itch PE=1 SV=2)

HSP 1 Score: 751.895 bits (1940), Expect = 0.000e+0
Identity = 347/601 (57.74%), Postives = 450/601 (74.88%), Query Frame = 1 
Query:  739 PCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK-VDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            P  +S   S   P+N+V+  PLP  +E R  +  R+YY+D + K ++W++P+P+P GWERR+D  GR+YYVDH TR+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      AT+   + D L PLP GWE+R D+N RVY+VNH  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR     +DN        D  AK+  FRF CQ   +  HIKI V+RK L  DSF QIM   P  LR+RL++ F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL ++KE ++ EC LE+YFS D EILG++++ +LKP G +ILVTE+NKEEYI ++  WR +RG+E Q ++F +GFNE+LP  +L YFD KE+E+LLCGMQ+I+++DW++H +YRHYT+ SKQI+ FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  269 PLTIS-GGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLF----ATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRATTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 864
[Close]
BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A2T7NHA3 (E3 ubiquitin-protein ligase OS=Pomacea canaliculata OX=400727 GN=C0Q70_18710 PE=4 SV=1)

HSP 1 Score: 805.823 bits (2080), Expect = 0.000e+0
Identity = 422/852 (49.53%), Postives = 557/852 (65.38%), Query Frame = 1 
Query:   94 IKLHFNVVKLKNLKILFNHKPSFFLDITLDNSQNHITS-KKQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILK-FTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECS--------------------------------STALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +++     KL +   LF+ KP  +L++ +D      T   +++  P W + F       SKI   L++   N +   ++V+   ++ L ++L++  GK DN      LKK+ +L+        + ++L    V  W     T N    RSS  +  G + +       A +  T ++  + E  ++  R   S +  S ++N S  +    P P + P   S  S                                +TA P  + N EPLP  +EMRR    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRPN +M+TN   WQEWR   NN   +A  R +     L P++      ++D L PLP GWE+R D+N RVY+VNH+NRTTQWEDPR QG     PLP+GWE+RY  +G  +F+DHNT+ +T+ DPR            + +  E     K+  FR+LC SN + GH+KINVSR  L  DSF QIM++QP  LR+RLYI FKGEEGLDYGGVAREWFF +S ++LNPM CLFEYA ++NYSL+INPAS VNP+HL YFRF+GRFIAMAL+HGKFIDSGFTL FYKRMLNKK  ++D+E++D  +Y SL ++KE ++++CDLELYF ADFEILGK+E  ELK GG +I V E+NKEEYI+LM  WRF RG+E Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQ+I+VDDWE++T+YRHY +NSKQ++ FWK+VR + NE R RLLQFVTGTCRLP+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPY+S+ QL EKLN AI+ETEGF  +
Sbjct:   17 LQVTIQSAKLTSTGGLFSSKPDPYLELIVDGQPPRKTEVARKTTSPKWDEHFTVLVTPYSKIE--LRVLGSNSIR-TDTVLGQASINLYSLLEETQGKFDN------LKKTFDLKTDKGKSGEVVVVLHGLEVNMWRYPKKTTNGP--RSS--VANGATANGTASTSAAAASTTTAQAGSGEAKTQGGRLTRSSSTSSQQSNASSRL----PGPPASPAATSVSSSVSLPPAPGPVAPPDPPSGTAPPAAPAGASATNTAGPDPNAN-EPLPPGWEMRRDNQGRTYYVDHNTRTTTWERPQPLPLGWERRVDPRGRVYYVDHNTRTTTWQRPNTDMVTNWHNWQEWR---NNRTMDAMNRRF-----LFPQMPQ--PAENDPLGPLPEGWEKRADSNGRVYFVNHKNRTTQWEDPRTQGIMQEDPLPEGWEMRYTQEGVRYFVDHNTRTTTFQDPRGGPQKGPKGAYGVPIQYERSFRWKLGQFRYLCHSNALPGHVKINVSRDSLFEDSFAQIMRLQPFDLRRRLYIIFKGEEGLDYGGVAREWFFHVSHDVLNPMYCLFEYASNSNYSLQINPASSVNPDHLLYFRFIGRFIAMALYHGKFIDSGFTLPFYKRMLNKKLTIKDLESIDPEFYQSLLWVKENNIDDCDLELYFCADFEILGKIEQHELKAGGSTIRVCEENKEEYINLMTQWRFTRGVEEQTKAFLEGFNEVVPLQWLQYFDERELELMLCGMQEIDVDDWERNTIYRHYQRNSKQVVWFWKFVREIDNEKRTRLLQFVTGTCRLPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYRSYDQLVEKLNLAIEETEGFGQE 840
[Close]
BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A0B6YT33 (E3 ubiquitin-protein ligase OS=Arion vulgaris OX=1028688 GN=ORF36226 PE=4 SV=1)

HSP 1 Score: 790.801 bits (2041), Expect = 0.000e+0
Identity = 409/845 (48.40%), Postives = 539/845 (63.79%), Query Frame = 1 
Query:  139 LFNHKPSFFLDITLDNSQNHITSK-KQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLK-----KSNELQNMLQNY-CNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLS-KASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTALPINSVN----------------------------------DEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMK----------VDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            LF+ KP  +L++++D      T    ++  P W ++F       SK++  LK+   N +   ++++    L L  +L+K  GK  N    V LK     K+ EL   L     NM    K T    P      N ++  S+     G++ S            T  + D I   + +  R  N                N +P P S   NV+  +ST+ P++S                                    +EPLP  +EMR     R YY+D   + +SWE+P P+P GWERR D  GRVYYVDHNTR+TTWQRPN   L+N + WQEWR  R     E F + +     L P+     Q + DQL PLP GWE+RVD +NRVY+VNH NRTTQWEDPR QG     PLP+GWE+RY  +   +F+DHNT+ +T+ DPR   +          +  E     K+  FR+LC SN + GH+KI VSR  L  DSF QIM++QP  LR+RLY+ FKGEEGLDYGG+AREWFF +S ++LNPM CLFEYA ++NYSL+INPAS +NP+HLQYF+F+GRFIAMAL+HGKFIDSGFTL FYKRML+KK  ++D+E +D  +Y SL ++KE D+++C LEL+F ADF++LGK+E  +LKPGG  I VTE+NKEEY++LM NWRF RG+E+Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQ+I+V+DWE++T+YRHY +NSKQ++ FWK V+ + NE R RLLQFVTGTCRLP+GGF  LMGS+GPQ+FCIEKVGKETWLPRSHTCFNRLDLPPY+S++QL EKLNYAI+ETEGF  +
Sbjct:   31 LFSSKPDPYLELSVDGQPPRKTEVCHRTTTPKWDEQFTVLVTPYSKLD--LKVLSCNSIR-TDTIIGHVMLELHPLLEKENGKFTNFSKTVDLKADGKSKAGELTISLNGMDVNMRNYPKKTKNG-PRAARVPNGSAAAST---SNGSTTSLPTSSTQPPQRQTSRQSDNIRVPAPRPPRGQNP---------------NGRPKPVSTASNVTSNASTSTPVSSAAPSTSSSRPSDTTADSGSVPAAPSTAPPAVPAPPSNEPLPPGWEMRTDAQGRFYYVDHNNRATSWERPLPLPRGWERRTDNRGRVYYVDHNTRTTTWQRPNTESLSNYANWQEWRGGRT---LEQFGQRF-----LFPQQPAPPQ-EIDQLGPLPEGWEKRVDGSNRVYFVNHSNRTTQWEDPRTQGIMQEDPLPEGWEMRYTAESVRYFVDHNTRTTTFQDPRAGAQKGPKGAYGVPIQYERSFRWKLGQFRYLCHSNALPGHVKITVSRDILFEDSFAQIMRLQPFDLRRRLYVIFKGEEGLDYGGLAREWFFHVSHDVLNPMYCLFEYASNSNYSLQINPASSINPDHLQYFKFIGRFIAMALYHGKFIDSGFTLPFYKRMLSKKLTIKDLETIDAEFYQSLLWVKENDIDDCGLELFFCADFDMLGKVEQHDLKPGGSDIKVTEENKEEYLNLMTNWRFTRGVEDQTKAFLEGFNEVVPLQWLQYFDERELELMLCGMQEIDVEDWERNTIYRHYQRNSKQVVWFWKMVKEIDNEKRTRLLQFVTGTCRLPVGGFAELMGSSGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYRSYEQLVEKLNYAIEETEGFGQE 844
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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A210PNA0 (E3 ubiquitin-protein ligase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT14305 PE=4 SV=1)

HSP 1 Score: 786.949 bits (2031), Expect = 0.000e+0
Identity = 362/586 (61.77%), Postives = 456/586 (77.82%), Query Frame = 1 
Query:  790 NDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            ++EPLP  +EMR    +R YY+D  T+T++WE+PQ +P GWERR+D  GRVYYVDHNTR+TTWQRPN +M+ N   WQEWR+ R+  +++   R       L P  A   Q ++D L PLP GWE+RVDAN+RVY+VNH+NRTTQWEDPR QG     PLP+GWE+RY  +G  +F+DH TK +T+ DPR            + +  E     K+  FR+LC SN + GH+KI VSR +L  DSF QIM++QP  LR+RLYI FKGEEGLDYGGVAREWFF LS ++LNPM CLFEYA  +NYSL+IN AS VNP+HL YFRF+GRFIAMAL+HGKFIDSGFTL FYKRMLNKK  L DIE +D  ++NSL +I++ +++EC LEL+FSADFE+LGK+E  +LK GG  I VTE+NKEEYI+LM NWRF RG+E+Q ++F+ GF+EV+PL WL YFDE+E+EL+LCGMQ+++VDDWE++T+YRHY +NSKQ++ FWK+VR + NE R RL+QFVTGTCRLP+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPY++++QL EKL  AI+ETEGF  +
Sbjct:  290 SNEPLPPGWEMRTDGHSRPYYVDHNTRTTTWERPQALPPGWERRVDPRGRVYYVDHNTRTTTWQRPNIDMVNNYQQWQEWRNNRSIALEQLQNRF------LFPNPAQVTQ-ENDPLGPLPEGWEKRVDANSRVYFVNHKNRTTQWEDPRTQGIVQEDPLPEGWEMRYTAEGVRYFVDHKTKSTTFQDPRGGPSKGPKGAFGVPIQYERSFRWKLGQFRYLCSSNALSGHVKITVSRDNLFEDSFAQIMRLQPYDLRRRLYIIFKGEEGLDYGGVAREWFFHLSHDVLNPMYCLFEYASHSNYSLQINAASNVNPDHLVYFRFIGRFIAMALYHGKFIDSGFTLPFYKRMLNKKLHLTDIETIDPEFFNSLTWIQDNNIDECGLELFFSADFEVLGKIEQHDLKEGGADIRVTEENKEEYINLMTNWRFQRGVEDQTKAFLDGFSEVVPLQWLQYFDERELELMLCGMQEVDVDDWERNTIYRHYQRNSKQVVWFWKFVREIDNEKRTRLMQFVTGTCRLPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYRTYEQLVEKLTMAIEETEGFGQE 868
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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A2C9JU47 (E3 ubiquitin-protein ligase OS=Biomphalaria glabrata OX=6526 GN=106068453 PE=4 SV=1)

HSP 1 Score: 786.178 bits (2029), Expect = 0.000e+0
Identity = 364/587 (62.01%), Postives = 455/587 (77.51%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            V+ EPLP  +EMR     R YY+D  T+T++WE+PQP+P GWERR D  GR YYVDHNTR+TTWQ P+   L N + WQEWR    N   E F + +     L P+ A   Q ++D L PLP GWE+RVD+NNRVY+VNH NRTTQWEDPR QG     PLP+GWE+RY  +G  +F+DHNT+ +T+ DPR            + +  E     K+  FR+LC SN + GH+KI VSR +L  DSF QIM++QP  LR+RLYI FKGEEGLDYGG+AREWFF +S ++LNPM CLFEYA ++NYSL+INPAS +NP+HLQYF+F+GRFIAMAL+HGKFIDSGFTL FYKRML+KK  ++D+E +D  +Y SL ++KE ++ +C LELYF ADFEILGK+E  +LKPGG  I VTE+NKEEY++LM NWRF RG+E+Q ++F++GFNEV+PL WL YFDE+E+EL+LCGMQ+I+VDDWE++T+YRHY +NSKQ++ FWK VR + NE R RLLQFVTGTCRLP+GGF  LMGSNGPQ+FCIEKVGKETWLPRSHTCFNRLDLPPY+S++QL EKLNYAI+ETEGF  +
Sbjct:  265 VSTEPLPPGWEMRTDVHGRPYYVDHNTRTTTWERPQPLPRGWERRTDPRGRTYYVDHNTRTTTWQCPSTESLNNYANWQEWRG---NRTLEQFGQRF-----LYPQQAAPAQ-ENDPLGPLPDGWEKRVDSNNRVYFVNHRNRTTQWEDPRTQGIMQEDPLPEGWEMRYTAEGVRYFVDHNTRTTTFQDPRGGPQKGPKGAYGVPIQYERSFRWKLGQFRYLCHSNTLPGHVKITVSRDNLFEDSFAQIMRLQPFDLRRRLYIIFKGEEGLDYGGLAREWFFHVSHDVLNPMYCLFEYASNSNYSLQINPASSINPDHLQYFKFIGRFIAMALYHGKFIDSGFTLPFYKRMLSKKLTIKDLETIDSEFYQSLLWVKENNIEDCGLELYFCADFEILGKVEQHDLKPGGSEIKVTEENKEEYLNLMTNWRFTRGVEDQTKAFLEGFNEVVPLQWLQYFDERELELMLCGMQEIDVDDWERNTIYRHYQRNSKQVVWFWKMVREIDNEKRTRLLQFVTGTCRLPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYRSYEQLVEKLNYAIEETEGFGQE 842
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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Match: A0A4W3IYB1 (E3 ubiquitin-protein ligase OS=Callorhinchus milii OX=7868 GN=wwp1 PE=4 SV=1)

HSP 1 Score: 785.793 bits (2028), Expect = 0.000e+0
Identity = 359/587 (61.16%), Postives = 455/587 (77.51%), Query Frame = 1 
Query:  781 NSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            NS+N EPLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ+   R LY   N L+  +A+    ++D L PLP GWERRVDAN+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRMLNKK  ++D+E++D  +YNSL +I++ ++ EC LE+YF+ D EILGK+ + ELK GG +ILVTE+NKEEYI LM  WRF RG+E Q  +F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  246 NSINTEPLPTGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSVSNWLI--LASMLSAENDPLGPLPPGWERRVDANDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFQDPRTGKSSVAKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLNKKLTIKDLESIDPEFYNSLIWIRDNNIEECGLEMYFAVDMEILGKVTSHELKAGGSNILVTEENKEEYIGLMAEWRFTRGVEEQTRAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLTDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAELLGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 830
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:103040182])

HSP 1 Score: 775.778 bits (2002), Expect = 0.000e+0
Identity = 354/587 (60.31%), Postives = 451/587 (76.83%), Query Frame = 1 
Query:  781 NSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +S   +PLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD+N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KI VSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRMLNKK IL+D+E++D  +YNSL +I++ ++ EC LE+YFS D EILGK+ + +LKP G +ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQI+ FW++V+ + NE+R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKSF+QL EKL +AI+ETEGF  +
Sbjct:  343 SSGTADPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMSAENDPLGPLPPGWERRVDSNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSSVTKGPQIAYERSFRWKLAHFRYLCQSNALSSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDNNIEECSLEMYFSVDMEILGKITSHDLKPDGANILVTEENKEEYIGLMAEWRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIMWFWQFVKEVDNEVRLRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE 920
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: itcha (E3 ubiquitin-protein ligase Itchy-like [Source:NCBI gene;Acc:103032591])

HSP 1 Score: 749.584 bits (1934), Expect = 0.000e+0
Identity = 348/595 (58.49%), Postives = 446/595 (74.96%), Query Frame = 1 
Query:  757 CSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM-------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             S T   ++ +N+ PLP  +E R  ++ R+Y++D + K ++WE+P+P+P GWERRLD  GRVYYVDH +R+TTWQRP A  + N   WQ  RS+    M +   R +YG  + L P     F    D L PLP GWE+R D+N R+Y+V+H  RTTQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR          ++    D  AK+  FRF CQ   +  HIKI+V+RK L  DSF QIM   P  LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL+YF+F+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL +IKE +L EC+LE+YFS D EILG++ T ELKP G +ILVTE+NKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E++LCGMQ+I++ DW+++T+YRHY ++SKQII FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL  AI+ETEGF  +
Sbjct:  263 VSPTPPRVSPINNGPLPPGWEQRVDQNGRLYFVDHIEKRTTWERPEPLPPGWERRLDPMGRVYYVDHISRTTTWQRPTAESVRNYEEWQNQRSQLQGAMHQFNQRFIYGLQDQLAPAANKEF----DPLGPLPQGWEKRTDSNGRMYFVHHPTRTTQWEDPRTQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRRTTYIDPRTGKSSLENGPQITYVRDFKAKVHYFRFWCQQLSMPQHIKIHVNRKTLFEDSFQQIMSFHPQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSINPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKENNLQECELEMYFSVDKEILGEVTTHELKPDGGNILVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLSDWQRNTIYRHYARSSKQIIWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLTLAIEETEGFGQE 853
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: itcha (E3 ubiquitin-protein ligase Itchy-like [Source:NCBI gene;Acc:103032591])

HSP 1 Score: 748.429 bits (1931), Expect = 0.000e+0
Identity = 348/595 (58.49%), Postives = 446/595 (74.96%), Query Frame = 1 
Query:  757 CSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM-------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
             S T   ++ +N+ PLP  +E R  ++ R+Y++D + K ++WE+P+P+P GWERRLD  GRVYYVDH +R+TTWQRP A  + N   WQ  RS+    M +   R +YG  + L P     F    D L PLP GWE+R D+N R+Y+V+H  RTTQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR          ++    D  AK+  FRF CQ   +  HIKI+V+RK L  DSF QIM   P  LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL+YF+F+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL +IKE +L EC+LE+YFS D EILG++ T ELKP G +ILVTE+NKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E++LCGMQ+I++ DW+++T+YRHY ++SKQII FW++V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EKL  AI+ETEGF  +
Sbjct:  182 VSPTPPRVSPINNGPLPPGWEQRVDQNGRLYFVDHIEKRTTWERPEPLPPGWERRLDPMGRVYYVDHISRTTTWQRPTAESVRNYEEWQNQRSQLQGAMHQFNQRFIYGLQDQLAPAANKEF----DPLGPLPQGWEKRTDSNGRMYFVHHPTRTTQWEDPRTQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRRTTYIDPRTGKSSLENGPQITYVRDFKAKVHYFRFWCQQLSMPQHIKIHVNRKTLFEDSFQQIMSFHPQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSINPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKENNLQECELEMYFSVDKEILGEVTTHELKPDGGNILVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLSDWQRNTIYRHYARSSKQIIWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLTLAIEETEGFGQE 772
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: itchb (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:103022206])

HSP 1 Score: 730.324 bits (1884), Expect = 0.000e+0
Identity = 338/585 (57.78%), Postives = 430/585 (73.50%), Query Frame = 1 
Query:  784 SVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM-------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            S+   PLP  +E R  ++ R+Y++D + K ++WE+P+P+P GWERR+D  GRVY+VDH TRSTTWQRP    + N   WQ  RS+    M +   R    +   +P     F    D L PLP GWE+R DAN RVY+V+H  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR          ++    D  AK+  FRF CQ   +  HIKINV+RK L  DSF QIM      LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+  FYKR+LNK   L D+E++D  +YNSL +IKE ++ EC LE++FS D +ILG++ T ELKP G  I VTE+NKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E+LLCGMQ+I++ DW+++T+YRHYT+ +KQI+ FW+ V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEK GKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  294 SMATGPLPPGWEQRVDQNGRMYFVDHVEKRTTWERPEPLPPGWERRVDPMGRVYFVDHTTRSTTWQRPTVETVRNYEQWQHQRSQLEGAMHQFNRRFIVGEPQAVPAQNKEF----DPLGPLPHGWEKRTDANGRVYFVHHPTRCTQWEDPRSQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSSLENGPQITYVRDFKAKVQYFRFWCQQLALPQHIKINVTRKTLFEDSFQQIMSFSAQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSQPFYKRILNKPLGLGDLESIDPEFYNSLIWIKENNIEECGLEMFFSVDKDILGEITTHELKPEGGDIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVLLCGMQEIDLADWQRNTIYRHYTRGNKQIVWFWQLVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKTGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 874
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Match: itchb (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:103022206])

HSP 1 Score: 720.694 bits (1859), Expect = 0.000e+0
Identity = 335/575 (58.26%), Postives = 426/575 (74.09%), Query Frame = 1 
Query:  814 YEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM-------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +E R  ++ R+Y++D + K ++WE+P+P+P GWERR+D  GRVY+VDH TRSTTWQRP    + N   WQ  RS+    M + F R +      +P     F    D L PLP GWE+R DAN RVY+V+H  R TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR          ++    D  AK+  FRF CQ   +  HIKINV+RK L  DSF QIM      LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YFRF+GRFIAMALFHGKFID+GF+  FYKR+LNK   L D+E++D  +YNSL +IKE ++ EC LE++FS D +ILG++ T ELKP G  I VTE+NKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E+LLCGMQ+I++ DW+++T+YRHYT+ +KQI+ FW+ V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEK GKE WLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  211 WEQRVDQNGRMYFVDHVEKRTTWERPEPLPPGWERRVDPMGRVYFVDHTTRSTTWQRPTVETVRNYEQWQHQRSQLEGAMHQ-FNRRFIVGPQAVPAQNKEF----DPLGPLPHGWEKRTDANGRVYFVHHPTRCTQWEDPRSQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSSLENGPQITYVRDFKAKVQYFRFWCQQLALPQHIKINVTRKTLFEDSFQQIMSFSAQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSQPFYKRILNKPLGLGDLESIDPEFYNSLIWIKENNIEECGLEMFFSVDKDILGEITTHELKPEGGDIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVLLCGMQEIDLADWQRNTIYRHYTRGNKQIVWFWQLVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKTGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 780

HSP 2 Score: 59.3066 bits (142), Expect = 1.889e-8
Identity = 27/74 (36.49%), Postives = 39/74 (52.70%), Query Frame = 1 
Query:  799 PLPQFYEMRRTKDNRIYYIDRLTKTSSWEKP--------QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNAN 996
            PLP  +E R   + R+Y++   T+ + WE P        +P+P GWE R    G  Y+VDHN R+TT+  P   
Sbjct:  316 PLPHGWEKRTDANGRVYFVHHPTRCTQWEDPRSQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG 389
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-000607-82])

HSP 1 Score: 646.736 bits (1667), Expect = 0.000e+0
Identity = 312/621 (50.24%), Postives = 411/621 (66.18%), Query Frame = 1 
Query:  709 QNSQPPPESEPC-------NVSECSSTALPINSVND--EPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG-----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWD-------LSAKIATFRFLCQSNGVDGHIKINVSRKDLLT-DSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            Q+  P P   P        +V+ C +TAL   +      P    +E R     R+Y++D  TKT++WE+PQP+P GWERR+D  GRVYYVDHNTR+TTWQRP    + N   WQ  R++    MQ  F + +      LP       T++D L  LP GWE+R++   R+Y+VNH  RTTQWEDPR QG      PLPDGWE R+  +G  +F+DH  + +T+ DPR   K    +        L +    F     S+ +  H +  +      T    N  +   P        +             +REWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GF+L FYKRMLNKK  ++D+E++D  +YNSL ++++ ++ EC LE++FS D E+LGK+ + +LKP G  ILVTE+NKEEYI LM  WRF+RG+E Q ++F+ GF+EV+PL WL YFDE+E+E++LCGMQ+I++ DW++ T+YRHY ++SKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF  L+GSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL YAI+ETEGF  +
Sbjct:  320 QDQTPLPPGNPTVPTLWGGDVTRCGATALTGGAPPTLRPPCAARWEQRADPHGRLYFVDHNTKTTTWERPQPLPPGWERRVDVRGRVYYVDHNTRTTTWQRPTTESVRNFEQWQSQRNQLQGAMQ-LFNQRFLFQTGGLP-------TENDPLGALPSGWEKRIEQGGRMYFVNHNTRTTQWEDPRTQGCVLSEEPLPDGWETRFTNEGVRYFVDHTMRTTTFQDPRPGAKAAGHFGAHIPSHLLQSHPHHFGVHIPSHLLQSHPQFGIPPDTCYTFAGRNGAVPTPPASSTLTASLPACPPPPSALMSASREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLAYFRFIGRFIAMALYHGKFIDTGFSLPFYKRMLNKKLTIKDLESIDPEFYNSLIWLRDNNIEECGLEMFFSVDMELLGKVSSHDLKPDGSDILVTEENKEEYIGLMTEWRFSRGVEEQTKAFLDGFSEVVPLQWLLYFDERELEVMLCGMQEIDLADWQRSTIYRHYNRSSKQISWFWQVVKEMDNEKRLRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 932
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 415.616 bits (1067), Expect = 8.666e-136
Identity = 223/470 (47.45%), Postives = 296/470 (62.98%), Query Frame = 1 
Query: 1147 LPIGWERRVDANNRVYYVNHENRTTQWED--------PRYQGPPLPD-GWEIRYNVDGKPFFIDHNTKISTYLDPR------KFMKVDNEWDLSAKIATFRF-LCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRK-RLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPAS-FVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGK-LETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRH-YTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            LP GWE R   N R ++++H NRTT W          PR+   PLP  GWE R + DG+ F+IDHNTK + + DPR          V    D   K   FR  L +   +    ++ + R  +L DS+ +I+ ++   L K RL+I F GE+GLDYGGVAREWFF +S+E+ NP   LFEY+  +NY+L+INP S   N EHL YF F+GR   MA+FHGK +D  F   FYK ML K   L D+E+VD  YYNSL +I E D    DL+L F  D E+ G+     ELKP G  ILVT +NK+EYI+L++ WRF   ++ Q  +F++GF+E++P++ +  FDE E+ELL+CG+ D++V+DW +HT+Y++ Y  N   I  FWK V  +  E R+RLLQFVTGT R+P+ GF  L GSNGPQ F IE       LPR+HTCFNRLDLPPY+SF  L EKLN AI+  +GF
Sbjct:   23 LPAGWEMRFAPNGRPFFIDHNNRTTTWSHISLSTMLHPRFSLFPLPHPGWEERTHSDGRTFYIDHNTKNTQWEDPRLQNPAITGPAVPYSRDYKQKYDFFRKKLKKPADIPNRFEMKLHRASILEDSYRRIVAVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPISGLCNEEHLSYFTFIGRVAGMAVFHGKLLDGFFIRPFYKMMLQKPITLNDMESVDSEYYNSLMWILEND--PADLDLRFCIDEEMFGQQTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNSYCANHPVIQWFWKAVLLMDGEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEMWSTSEKLPRAHTCFNRLDLPPYESFDDLREKLNIAIENAQGF 490

HSP 2 Score: 54.6842 bits (130), Expect = 6.833e-8
Identity = 31/101 (30.69%), Postives = 46/101 (45.54%), Query Frame = 1 
Query:  727 PESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEK--------------PQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP 987
            P++ P    +      P  S     LP  +EMR   + R ++ID   +T++W                P P P GWE R    GR +Y+DHNT++T W+ P
Sbjct:    2 PQASPYGSPKQKHKGCPGFSF----LPAGWEMRFAPNGRPFFIDHNNRTTTWSHISLSTMLHPRFSLFPLPHP-GWEERTHSDGRTFYIDHNTKNTQWEDP 97
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: smurf2 (SMAD specific E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:563633])

HSP 1 Score: 359.762 bits (922), Expect = 3.147e-111
Identity = 213/588 (36.22%), Postives = 308/588 (52.38%), Query Frame = 1 
Query:  889 PQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPN-----ANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNAL-----LPRVAT------NFQTDSDQLEP--LPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----------PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR---------------------------KFMKVDNEW-------DLSAKIATFRF-LCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEIL--GKLE--TQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKET-WLPRSHTCFNRLDLP--PYKS 2442
            P  +P GWE R    GR  YV+H TR+  W+RP            V+  QE    R     +  A   G  +A       P + T      NF + +   +P  LP G+E+R     ++Y+++ +   + W DPR              PLP GWE R    G+ +F+DHN + + + DPR                                D E        DL  K+   R  L       GH ++ VSR ++  +S+ Q+M+++P  L+KRL + F+GEEGLDYGGVAREW + LS E+LNP   LF+Y+ D+ Y+L+INP S +NPEHL YF FVGR + MA+FHG +ID GFTL FYK++L K   L D+E VD   + SL +I    LN  D+ +           G+++   + +  G  +++     +     L V+WRF RGIE Q  +  KGFNE++P   L  FDEKE+EL++ G+  I+V DW+ +T  +H T  S  +  FW+ V +   E R RLLQFVTG+ R+P+ GFK L G+ GP+ F I  +  +T  LP++HTCFNR+D+   PY++
Sbjct:  156 PNDLPEGWEERRSTMGRTQYVNHVTRTAQWERPTRPAAECGGPGCVAPGQEGTPLRAGQGADGRATTAGEPSAAPAAPGSPELGTRSQRHRNFLSRTHLHQPPDLPEGYEQRTTQQGQIYFLHTQTGVSTWHDPRVPRDLSHVNCEDLGPLPAGWETRSTATGRVYFVDHNNRTTQFTDPRLSANLHHLLKNRQTQQGPCPPGLPPGPPPPPADEECPVPRYKRDLVQKLKCLRQELALQQSQAGHCRLEVSRTEIFEESYRQVMKMRPRDLKKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAINPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLADMETVDPELHKSLVWI----LNNSDVNILHEHTVHSCWGGRVQFCFRTVNKGVPAMIRLAPRR-----LYVSWRFLRGIEAQFLALQKGFNELIPQPLLKSFDEKELELIIGGLGKIDVSDWKSNTRLKHCTPESSVVRWFWRAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHLIDAKTDNLPKAHTCFNRIDITRNPYET 734

HSP 2 Score: 61.2326 bits (147), Expect = 9.803e-10
Identity = 31/82 (37.80%), Postives = 45/82 (54.88%), Query Frame = 1 
Query:  802 LPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQ--------------PIPSGWERRLDGHGRVYYVDHNTRSTTWQRP--NANM 999
            LP+ YE R T+  +IY++   T  S+W  P+              P+P+GWE R    GRVY+VDHN R+T +  P  +AN+
Sbjct:  260 LPEGYEQRTTQQGQIYFLHTQTGVSTWHDPRVPRDLSHVNCEDLGPLPAGWETRSTATGRVYFVDHNNRTTQFTDPRLSANL 341
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005015.1 (pep scaffold:Pmarinus_7.0:GL486731:734:6293:1 gene:ENSPMAG00000004557.1 transcript:ENSPMAT00000005015.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 182.57 bits (462), Expect = 1.998e-53
Identity = 82/164 (50.00%), Postives = 118/164 (71.95%), Query Frame = 1 
Query: 2008 IDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRH-YTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            + L++ WRF   ++ Q  +F++GF E++P++ +  FDE E+ELL+CG+ D++V++W +HTVY++ Y  N   +  FWK V  +  E R+RLLQFVTGT R+P+ GF  L GSNGPQ F +E  G    LPR+HTCFNRLDLPPY+SF++L E+LN AI+  +GF
Sbjct:    1 VSLVIQWRFVSRVQKQMNAFMEGFCELIPMDLIKIFDENELELLVCGLGDVDVNNWRQHTVYKNGYCANHPVVQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTVEMWGAPEKLPRAHTCFNRLDLPPYESFEELRERLNMAIENAQGF 164
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Match: AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:20363])

HSP 1 Score: 185.652 bits (470), Expect = 7.072e-50
Identity = 130/376 (34.57%), Postives = 194/376 (51.60%), Query Frame = 1 
Query: 1438 IKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEH--LQYFRFVGRFIAMALF-------HGKFIDSGFTLSFYKRM--LNKKPILEDIEAVDYLYYNS-LKFIKEMDLNECDLELYFSADFEILGKL-ETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESF-----IKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQN--SKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKE-TEGFSM 2502
            I + VSR+ LL  S   +         +   +TF+ EE LD GG  REWF  + + L  P   LF +  D+N +L ++P     P H  L+ +   GR +   LF       + + + + FT SF  ++  L+ + +    E  D  +Y + + F+   D++E DL L     ++  GKL +  +L PGG  I VT  NK  Y++++  +R    +  + E F     IKG NE++P N L  FDE E+E+L+CG +DI+VDD++ + V    + +   K I+ FW  V + T E   RLLQF TG+  LP GGF  L        F I    K   LP +HTCFN+L LP Y S ++L + L YAI E +EGF +
Sbjct:  244 ISLRVSRQCLLDSSVKAVRNFSSNDWFRSFEVTFENEEALDRGGPRREWFELMCKALFEPANKLFTHFVDDNQAL-VHPNPH-RPHHMRLRLYELAGRLVGKCLFETSLGDTYRQLVRARFTRSFLAQLIGLHVRFLYFYFETDDPEFYKTKVSFVLNNDVSEMDLTLSEEV-YDEQGKLSQLVDLVPGGSGIGVTNANKLAYLNVLAQYRLATQVRTEVEHFLKVLSIKGLNEMVPENLLAIFDENELEMLMCGTEDISVDDFKANAVLVGASWHFRKKVILWFWAVVSSFTQEELARLLQFSTGSSLLPTGGFAAL-----SPPFQIVSSPKHGTLPTAHTCFNQLCLPTYDSCEELHKMLRYAITEGSEGFGL 611
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 451.055 bits (1159), Expect = 1.701e-145
Identity = 237/595 (39.83%), Postives = 345/595 (57.98%), Query Frame = 1 
Query:  802 LPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWER--RLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQ------GP--------------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDN-----EWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            LP  +E R     R YY+D  T+T++W++P    +  ER  +L+ +  +    H  R+      + + +T               +Q          N             +  L  LP GWE+R     R Y+V+H  RTT W DPR Q      GP              PLP GWE+R     + +F+DHNTK +T+ DPR    +D      + D   K+  FR       + G   I V RK++  D++ +IM+  P  L+KRL I F GEEGLDYGGV+RE+FF LS E+ NP  CLFEY+  +NY+++INP S +NPEHL YF+F+GR + + +FH +F+D+ F  + YK ML KK +L+D+E VD   YNSL ++ E  ++   L+L FSAD E  G++ T +LKP G +I VT+ NK+EY++L   WR    ++ Q ++F+ GFNE++P + +  FDE+E+ELL+ G+ +I+++DW+KHT YR Y ++ + I  FWK V    NE R RLLQF TGT R+P+ GFK+L GS+GP++F IEK G+   LP+SHTCFNR+DLP Y  +  + +KL  A++ET GF  +
Sbjct:  231 LPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELERRQHRGRTLPGGSSDNSSVT---------------VQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV-LDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE 809
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 266.929 bits (681), Expect = 2.728e-74
Identity = 141/358 (39.39%), Postives = 217/358 (60.61%), Query Frame = 1 
Query: 1438 IKINVSRKDLLTDSFNQIMQIQPTHLR-KRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEK-VGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKET-EGFSM 2502
            + I V R+ +  DS+  +       ++  +L ITFKGE G+D GGV REW+  LS+++ NP   LF     +  +   N  S +NPEHL +F+F+G  I  A+    F+D  F+   YK +L +   L+D+E++D  YY SL +I E D+ +  +E  FS + +  G+ +   L  GG  I+VTE NK++Y+  +V ++    ++ Q ++F+ GF  ++  + +  FDE+E+ELL+ G+ DI+VDDW+ +T Y +YT   K++ +FW+ VR+   E R +LLQFVTGT ++P+ GFK L G NG  KF I +  G    LP SHTCFN+L+LPPY+S++ L   L  AI E  EGF +
Sbjct: 2911 LPITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDITDI-IEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGL 3267
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 142.124 bits (357), Expect = 5.210e-35
Identity = 124/425 (29.18%), Postives = 205/425 (48.24%), Query Frame = 1 
Query: 1297 PFFIDHNTKISTY-LDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYS-LKINPASFVNPE----HLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFE--------ILGKLE------TQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLP-LNWLYYFDEKEIELLLCGMQDINVDDWEK-HTVYRH---YTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            PF +    KIS    + R+ M+ +      A+ A    L +   VD + KI V R  +  DS   I + Q   L K L I F  E G+D GG+ +EWFF L++ L NPM  LF Y  +++ S   I+P +F   +     L+ +   G  + +A+F+   +D  F  + YK++ ++    ED    +     S   IK ++  E + E  FS  FE        IL   +      T EL   G ++ +T+ NK E++   V +   + IE Q   F+ GF  V    N +  F+ +E+E L+CG ++    D++   +V ++   ++ +S+ +  FW+ + +    ++ +LLQFVT + R+P  G   +     P K  +        LP +HTCFN + L  Y S ++L  KL +AI E+EG+
Sbjct:  479 PFILSLGIKISIMEYEIRRIMEHE------AEQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEHQG-DLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYS--ELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTI-----PFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 141.739 bits (356), Expect = 7.356e-35
Identity = 118/419 (28.16%), Postives = 200/419 (47.73%), Query Frame = 1 
Query: 1297 PFFIDHNTKISTY-----LDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFK---GEE-GLDYGGVAREWFFRLSQE-LLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKK----PILEDIEAVDYLYYNSLKFIKEMDLNEC-DLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQD-INVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETW-LPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSM 2502
            PFFI    ++  +     LD ++ + +D++ +L      +     S G+     I +SR ++L D+FN    I     +  L +TF    GEE G+D GG+ +E+   +S E   +P   LF      N   ++ P+   +   L+Y  F+G+ +   L+    ID  F   F K++LN          D+ + D + YN+L  +  M  +E   L+L F  D E     +  +L P G    VT+DN   Y+  + +++ N+       +F  G + ++  +W+  F+  E+++L+ G +D I++DD + +T Y  Y +  + I+ FW+ +     E ++  L+FVT   + P+ GFK L       KF I   G E + LP + TC N L LP Y++   L EKL YAI     F +
Sbjct:  508 PFFIPFEERVDLFYMFIALDKKR-LSLDDDHNLINMFTPW----ASTGMRKQSAI-ISRDNVLEDAFNAFNSIGE-RFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFR----TNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEID-EPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKAL-----DPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Match: UFD4 (Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001493])

HSP 1 Score: 102.449 bits (254), Expect = 1.626e-22
Identity = 89/299 (29.77%), Postives = 141/299 (47.16%), Query Frame = 1 
Query: 1666 INPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYK---RML--NKKPILEDIEA-------VDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRH------YTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQ-----KFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEG 2493
            +NP S  N + ++ F ++G F+A +L   + +D  F+  F++   RM   N   +  D+E        VD L   SLK+I     +   LE   S  F + G  +  EL PGG +  +   N EEYI  +++    +GIE Q ++FI+GF++V     +      E+  +   ++    +DW   T+Y +      YT +S  I  F   +       R   LQF+TG+ +LPIGGFK+L     P+     K   + +  + +LP   TC N L LP Y S   +  +L  AI+E  G
Sbjct: 1191 LNPFSN-NEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLE-SLSLTFTVPGN-DDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVE----EDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSL----NPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAG 1478
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Match: EDO49328 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHD7])

HSP 1 Score: 693.345 bits (1788), Expect = 0.000e+0
Identity = 325/552 (58.88%), Postives = 406/552 (73.55%), Query Frame = 1 
Query:  790 NDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQ-----GPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFW-KYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHT 2406
            N+EPLP  +E R     RIYY+D  ++T++WE+PQP+P GWERR D  GR YYVDHNTR+TTWQRP A  +     WQ          ++ F + +     LLP    + + D+  L PLP GWE+RV+ N RVY+VNH  RTTQWEDPR Q       PLP GWE+RY  +G P+F+DHNT+ +T+ DPR       K      E     K+  FR LCQ+N +  HIKI VSR +L  +SF Q+M+ QP  LR+RLYITFKGEEGLDYGGVAREWFF LS E+LNPM CLFEYA  NNYSL+IN AS VNP+HL YF+F+GRFIAMAL+HGKFID GFTL FYKRMLNKK +++D+E +D  +YNSL ++KE ++ EC LE++F+ D E+LGK+ + +LKPGG  I V E+NKEEYI LM  WR NRGIE Q  +F++G +EVLPL W+ YFDE+E+EL+LCGMQ+I+V+DW+++TVYRHYT+NSKQ++ FW + V+   NE R+RLLQFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGKETWLPRSHT
Sbjct:  108 NEEPLPPGWEQRVDPHGRIYYVDHNSRTTAWERPQPLPHGWERRTDSRGRTYYVDHNTRTTTWQRPTAETIRTFENWQNQNRAMLGAERQQFQQRF-----LLPN-QQDAERDNGPLGPLPAGWEKRVETNGRVYFVNHNTRTTQWEDPRTQTTASADKPLPQGWEMRYTNEGIPYFVDHNTRTTTFTDPRGNGAPGVKGAAPAFERSFRWKVGQFRHLCQANTLPSHIKITVSRTNLFEESFQQVMRYQPHDLRRRLYITFKGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNNYSLQINAASSVNPDHLMYFKFIGRFIAMALYHGKFIDRGFTLPFYKRMLNKKLLMKDLETIDPEFYNSLVWVKENNIEECGLEMFFTVDMELLGKVTSHDLKPGGTDIAVIEENKEEYISLMTEWRLNRGIEEQTRAFLEGMHEVLPLYWIQYFDERELELMLCGMQEIDVEDWQQNTVYRHYTRNSKQVMWFWQQAVKAYDNEKRIRLLQFVTGTCRLPVGGFTELMGSNGPQKFCIEKVGKETWLPRSHT 653
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Match: EDO49327 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHD5])

HSP 1 Score: 542.347 bits (1396), Expect = 0.000e+0
Identity = 247/363 (68.04%), Postives = 305/363 (84.02%), Query Frame = 1 
Query: 1417 SNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +N +  HIKI VSR +L  +SF Q+M+ QP  LR+RLYITFKGEEGLDYGGVAREWFF LS E+LNPM CLFEYA  NNYSL+IN AS VNP+HL YF+F+GRFIAMAL+HGKFID GFTL FYKRMLNKK +++D+E +D  +YNSL ++KE ++ EC LE++F+ D E+LGK+ + +LKPGG  I VTE+NKEEYI LM  WR NRGIE Q  +F++G +EVLPL W+ YFDE+E+EL+LCGMQ+I+V+DW+++TVYRHYT+NSKQ++ FW+ V+   NE R+RLLQFVTGTCRLP+GGF  LMG NGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF+ +
Sbjct:    2 ANTLPSHIKITVSRTNLFEESFQQVMRYQPHDLRRRLYITFKGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNNYSLQINAASSVNPDHLMYFKFIGRFIAMALYHGKFIDRGFTLPFYKRMLNKKLLMKDLETIDPEFYNSLVWVKENNIEECGLEMFFTVDMELLGKVTSHDLKPGGTDIAVTEENKEEYISLMTEWRLNRGIEEQTRAFLEGMHEVLPLYWIQYFDERELELMLCGMQEIDVEDWQQNTVYRHYTRNSKQVMWFWQAVKAYDNEKRIRLLQFVTGTCRLPVGGFTELMGDNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLVEKLTFAIEETEGFAQE 364
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Match: EDO46071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR93])

HSP 1 Score: 419.853 bits (1078), Expect = 3.914e-131
Identity = 225/557 (40.39%), Postives = 328/557 (58.89%), Query Frame = 1 
Query:  931 HGRVYYVDHNTRSTTWQRPNANML-TNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQ-----LEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG-------------------PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEW-----DLSAKIATFRF-LCQSNGVDGHIKINVSRKDLLTDSFN--QIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPAS-FVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIH-FWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            H   +  D +T  T     +A+ L + +    + R +     +   AR + TD  +     T+  T ++      ++PLP GW  +   N R+++++H +RTT W DPR                       PLPDGWE R + DG+ F+IDH T+ + + DPR  +   ++      D   K   FR  L + + V    +I++ R++L+ DS+   Q+  ++P  L+ RL+I F GE GLDYGG+ REWF+ LS+E+ NP   LFEY+  +NY+L+INP S   N EHL YF+F+GR   MA++HGK +D+ F   FYK ML +   L D+E+VD  YYNSL +I E D    DL+L+F  D E+ G L  ++LKP G    VT +NK EYI+L++ WRF   +E+Q  +F++GF +++P N +  FDE+E+ELL+CG+ +I+  DW K++ YR    +   +I  FWK V +   E R RLLQFVTGT R+P+ GF  L GSNGPQ+F IE  G    LPR+HTCFNRLDLP Y+S+ +L E+L  AI+ T+GF
Sbjct:  431 HACRHAADTHTLQTRMTDAHADTLQSRMQTHMQSRMQTRTQARYRHARRHATDTHVDAHADTHADTHAETTQNALMDPLPPGWAVQRAPNGRLFFIDHNSRTTTWHDPRLTHLSQSPPSALPPSAPPAQDLGPLPDGWEERIHSDGRVFYIDHETRSTQWEDPRLQLNTTSQAVPYSRDYKRKCDYFRSKLKRPSNVPNKYEIHIRRRNLMEDSYRAVQLSIVKPEILKSRLWIVFDGETGLDYGGLQREWFYLLSKEVFNPYYGLFEYSASDNYTLQINPNSGLCNEEHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLGRPITLIDMESVDSEYYNSLNWILENDPE--DLDLHFCVDEELFGILSVKDLKPNGSQTNVTNENKREYINLVIKWRFVSRVEDQMRAFMEGFCDLIPHNLIQIFDERELELLMCGLGEIDTVDWRKNSNYRGEYHDKHIVIQWFWKAVNSFDIETRARLLQFVTGTSRVPMNGFSELYGSNGPQRFTIEPWGTPHSLPRAHTCFNRLDLPRYRSYYELRERLRIAIENTQGF 985

HSP 2 Score: 63.929 bits (154), Expect = 2.488e-10
Identity = 29/93 (31.18%), Postives = 48/93 (51.61%), Query Frame = 1 
Query:  796 EPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQ-----------------------PIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLT 1005
            +PLP  + ++R  + R+++ID  ++T++W  P+                       P+P GWE R+   GRV+Y+DH TRST W+ P   + T
Sbjct:  507 DPLPPGWAVQRAPNGRLFFIDHNSRTTTWHDPRLTHLSQSPPSALPPSAPPAQDLGPLPDGWEERIHSDGRVFYIDHETRSTQWEDPRLQLNT 599

HSP 3 Score: 57.3806 bits (137), Expect = 2.671e-8
Identity = 34/100 (34.00%), Postives = 49/100 (49.00%), Query Frame = 1 
Query:  856 DRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP-----NANMLTNVSLWQEWRSERNNNMQEA---FARLYGTDNALLPRVATNFQTDS 1131
            D   + S  ++P P+P GWE R D +GR +Y+DH TR+TTW RP     +A+  T  S  Q     R     +A    AR + TD  +     T+  T +
Sbjct:  192 DSAHRHSVEKQPPPLPEGWEERQDANGRTFYIDHTTRTTTWVRPSRHDTDAHADTLQSRMQTHMQSRMQTRTQARYRHARRHATDTHVDAHADTHADTHA 291
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Match: EDO49383 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG94])

HSP 1 Score: 317.775 bits (813), Expect = 2.053e-100
Identity = 154/330 (46.67%), Postives = 218/330 (66.06%), Query Frame = 1 
Query: 1516 RKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRH-YTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSM 2502
            R RL I F GEEGLDYGG ARE+FF +S+++ NP   LFEY+ ++ Y+++++P S       ++FRF GR + + + H   +D+ FT +FYK +L     L D+EA+D L++ S+ ++ E D+ +  L+L FS   EI G++  +EL PGG  I VTE NK +Y+  MV WR  RG+  Q ES ++GFNEV+    +  FD +E+EL++ G  DI++ DW ++T YR  Y  N K +  FWK V +  NE R+RLLQFVTGT  +P  GF  L GS GP+KF IE+ G  T LPR+HTCFNRLD+P Y+S+ +L EKL YA++ET  F+M
Sbjct:   10 RNRLEIQFAGEEGLDYGGPAREFFFLISRQIFNPYYGLFEYSANDTYTVQVSPVSLYVDNSHEWFRFCGRIVGLVIIHQHLLDAFFTRTFYKALLRSLCDLSDVEALDALFHQSMTWVIENDIEDV-LDLTFSVSEEIFGQVTERELIPGGKDIAVTEQNKGDYVAEMVKWRVERGVSEQMESIVRGFNEVIDPALVNIFDARELELVISGTADIDIKDWRRNTEYRSGYHDNHKVVKWFWKAVSSFDNEQRLRLLQFVTGTSSIPYEGFAALRGSTGPRKFSIERWGDYTKLPRAHTCFNRLDMPIYRSYDELLEKLTYAVEETGSFAM 338
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Match: EDO30268 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T196])

HSP 1 Score: 195.667 bits (496), Expect = 3.615e-52
Identity = 133/380 (35.00%), Postives = 203/380 (53.42%), Query Frame = 1 
Query: 1402 RFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPE-HLQYFRFVGRFIAMALFHGKF-------IDSGFTLSFYKRMLNKKPILEDIEAVDY-LYYNSLKFIKEMDLNECDLELYFSAD-FEILGKLE-TQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEK-HTVYRHYTQNSKQIIH-FWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKE-TEGFS 2499
            + L       G +++ ++R +LL  S+   +  +     K   +TF+GEEGLD+GGV REWF  L   L      LF     ++    ++P     P  +L+Y++F G+ ++  ++           + + FT SF  ++L  +   + +E+ D  LY + ++ I++ D    DLEL F+ + +   G+LE   EL PGG  I VTE NK EY++LM  ++    ++ + E+FI+G NE++P N L  FDE E+ELL+CG   I+V D +  H V     Q   +I+  FW  V +LT E   RLLQFVTG+ +LP GGF  L     PQ   I  +     LP +HTCFN+L LP + SF ++  KL  A+ E  EGF 
Sbjct:  390 KLLSHQGMKGGEVRLKINRSNLLESSY---VACKNVDWLKMFNVTFEGEEGLDWGGVRREWFELLCIALFGRDSELFTRFKGDDPQAPVHPNPRRPPHLNLKYYKFAGQVVSKCIYESAISNARRQNVKAKFTRSFLAQLLGLRVNYKYLESDDKDLYRSKVQLIEKND--PADLELKFTEEEYNSSGQLEKVVELLPGGRLIDVTEQNKCEYLNLMARYKLVESVQKEVEAFIQGLNELVPDNLLGMFDENELELLMCGTGHISVADMKAHHHVLAGGGQRFTKIMDWFWTIVSSLTQEELARLLQFVTGSSQLPPGGFAEL----SPQ-LQISYIATSQALPTAHTCFNQLCLPDFPSFNEMQRKLLLAVNEGCEGFG 759
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101169496])

HSP 1 Score: 770.77 bits (1989), Expect = 0.000e+0
Identity = 351/587 (59.80%), Postives = 450/587 (76.66%), Query Frame = 1 
Query:  781 NSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR-------KFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            N+ + +PLP  +E R+    R YY+D  T+T++WE+PQP+P GWERR+D  GR+YYVDHNTR+TTWQRP    + N   WQ  RS+    M +   R LY          A+    ++D L PLP GWERRVD+N+RVY+VNH  +TTQWEDPR QG     PLP+GWEIRY  +G  +F+DHNT+ +T+ DPR       K  ++  E     K+A FR+LCQSN +  H+KINVSR+ L  DSF QIM ++P  LR+RLY+ F+GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL YF F+GRFIAMALFHGKFID+GF+L FYKRMLNKK IL+D+E++D  +YNSL +I++ ++ EC LE++FS D EILGK+ + +LKP G +I VTE+NKEEYI  M  WRF+RG+E Q ++F+ GFNEV+PL WL YFDEKE+E++LCGMQ++++ DW+++TVYRHYT+NSKQII FW+ V+ + NE+R+RL+QFVTGTCRLP+GGF  LMGSNGPQKFCIEKVGK+TWLPRSHTCFNRLDLPPYKS++QL EKL +AI+ETEGF  +
Sbjct:  383 NAASSDPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDERGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYS---------ASMMTAENDPLGPLPPGWERRVDSNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSSVTKGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASAINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKITSHDLKPDGANIQVTEENKEEYISQMAEWRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 960
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: itcha (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:101167949])

HSP 1 Score: 746.117 bits (1925), Expect = 0.000e+0
Identity = 345/586 (58.87%), Postives = 441/586 (75.26%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR--KFMKVDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VN+ PLP  +E R  ++ R+YY+D + K ++W++P+P+P+GWERR+D  GRVYYVDH TR+TTWQRP    + N   WQ  RS+    MQ    R +YG  + L    +  F    D L PLP GWE+R D N RVY+V+H  RTTQWEDPR QG     PLP+GWE+R+ VDG P+++DHN + +TY+DPR  K   ++N        D  AK+  FRF CQ   +  HIKI VSRK L  DSF QIM   P  LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YF+F+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL +IK+ ++ EC LE++FS D EILG++ T ELKP G +I VTEDNKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E++LCGMQ+I++ DW+++T+YRHY +NSKQII FW++V+ + NE R+RLLQFV GTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYK+++QL EKL +AI+ETEGF  +
Sbjct:  298 VNNCPLPPGWEQRVDQNGRVYYVDHIEKRTTWDRPEPLPTGWERRVDPMGRVYYVDHITRTTTWQRPTQESVRNYEEWQHQRSQLQGAMQHFNQRFIYGLQDQLAAIASKEF----DPLGPLPHGWEKRTDTNGRVYFVHHPTRTTQWEDPRRQGLLNDKPLPEGWEMRFTVDGIPYYVDHNRRTTTYIDPRTGKSSSLENGPQITYVRDFKAKVQYFRFWCQQLSMPQHIKITVSRKTLFEDSFQQIMSFHPQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLTLKDLESIDPEFYNSLIWIKDNNIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEDNKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLADWQRNTIYRHYARNSKQIIWFWQFVKEMDNEKRMRLLQFVAGTCRLPMGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKTYEQLKEKLMFAIEETEGFGQE 879
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: itcha (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:101167949])

HSP 1 Score: 746.117 bits (1925), Expect = 0.000e+0
Identity = 345/586 (58.87%), Postives = 441/586 (75.26%), Query Frame = 1 
Query:  787 VNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR--KFMKVDNE------WDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VN+ PLP  +E R  ++ R+YY+D + K ++W++P+P+P+GWERR+D  GRVYYVDH TR+TTWQRP    + N   WQ  RS+    MQ    R +YG  + L    +  F    D L PLP GWE+R D N RVY+V+H  RTTQWEDPR QG     PLP+GWE+R+ VDG P+++DHN + +TY+DPR  K   ++N        D  AK+  FRF CQ   +  HIKI VSRK L  DSF QIM   P  LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS++NP+HL+YF+F+GRFIAMALFHGKFID+GF+L FYKR+LNK   L+D+E++D  +YNSL +IK+ ++ EC LE++FS D EILG++ T ELKP G +I VTEDNKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E++LCGMQ+I++ DW+++T+YRHY +NSKQII FW++V+ + NE R+RLLQFV GTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYK+++QL EKL +AI+ETEGF  +
Sbjct:  298 VNNCPLPPGWEQRVDQNGRVYYVDHIEKRTTWDRPEPLPTGWERRVDPMGRVYYVDHITRTTTWQRPTQESVRNYEEWQHQRSQLQGAMQHFNQRFIYGLQDQLAAIASKEF----DPLGPLPHGWEKRTDTNGRVYFVHHPTRTTQWEDPRRQGLLNDKPLPEGWEMRFTVDGIPYYVDHNRRTTTYIDPRTGKSSSLENGPQITYVRDFKAKVQYFRFWCQQLSMPQHIKITVSRKTLFEDSFQQIMSFHPQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLTLKDLESIDPEFYNSLIWIKDNNIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEDNKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLADWQRNTIYRHYARNSKQIIWFWQFVKEMDNEKRMRLLQFVAGTCRLPMGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKTYEQLKEKLMFAIEETEGFGQE 879
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: itchb (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:101174746])

HSP 1 Score: 741.495 bits (1913), Expect = 0.000e+0
Identity = 342/595 (57.48%), Postives = 445/595 (74.79%), Query Frame = 1 
Query:  763 STALP--INSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFM-------KVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            + +LP  + +V+  PLP  +E R  ++ R+YY+D + K ++W++P+P+P GWERR+D  GRVY+VDH +R+TTWQRP    + N   WQ  RS+    MQ+   R +YG  +      A     + D L PLP GWE+R DAN RVY+++H  R+TQWEDPR QG     PLP+GWE+R+ VDG P+F+DHN + +TY+DPR          ++    D  AKI  FRF CQ   +  HIKINV+RK+L  DSF QIM I    LR+RL+I F GEEGLDYGGVAREWFF LS E+LNPM CLFEYA  +NY L+INPAS +NP+HL+YFRF+GRFIAMALFHGKFI++GF+L FYKR+LNK   ++D+E++D  +YNSL +IK+ ++ EC LE++FS D EILG++ T ELKPGG  I VTE+NKEEYI L+  WR +RG+E Q ++F +GFNEVLP  +L YFD KE+E++LCGMQDI++ DW+++T+YRHY +NSKQI+ FW+ V+ + NE R+RLLQFVTGTCRLP+GGF +LMGSNGPQKFCIEKVGKE WLPRSHTCFNRLDLPPYKS++QL EK+ +AI+ETEGF  +
Sbjct:  287 TPSLPPRVPAVSTAPLPPGWEQRVDQNGRLYYVDHVEKRTTWDRPEPLPPGWERRVDQMGRVYFVDHISRTTTWQRPTMETVRNYEQWQHQRSQLQGAMQQFNQRFIYGVQDP----AAAAQNKEFDPLGPLPAGWEKRTDANGRVYFLHHPTRSTQWEDPRTQGLLNEKPLPEGWEMRFTVDGIPYFVDHNRRSTTYIDPRTGKSSLENGPQITYVRDFKAKIQYFRFWCQQLALPQHIKINVTRKNLFEDSFQQIMSINAPDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSINPDHLKYFRFIGRFIAMALFHGKFINTGFSLPFYKRILNKPLAVKDLESIDPEFYNSLMWIKDNNIEECCLEMFFSVDKEILGEITTHELKPGGGDIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQDIDLADWQRNTIYRHYARNSKQILWFWQLVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKVMFAIEETEGFGQE 877
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Match: wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:101168206])

HSP 1 Score: 739.954 bits (1909), Expect = 0.000e+0
Identity = 348/613 (56.77%), Postives = 442/613 (72.10%), Query Frame = 1 
Query:  709 QNSQPPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFAR-LYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSA---------KIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            Q +  P E  P   S    +       N + LP  +E R     R+YY+D  TKT++WE+P  +P+GWE+R+D  GR YYVDHNTR+TTWQRP A  + N   WQ  RS+    M +   R LY    A +         ++D L  LP GWE+R D N RVY+VNH  RTTQW+DPR QG     PLP GWE++Y  +G  +F+DHN++ +T+ DPR   +  +    S          K   FRFLC SN +  H+KI+VSR+ L  DSF QIM ++P  LR+RLYI  +GEEGLDYGG+AREWFF LS E+LNPM CLFEYA  NNY L+INPAS +NP+HL YFRF+GRFIAMAL+HGKFID+GFTL FYKRML+KKP L+D+E++D  +YNS+ ++KE +L EC +ELYF+ D EILGK+ T +LK  G + LVTE+NKEEYI L+ +WRF RG+E Q ++F+ GFNEV+PL WL YFDEKE+EL+LCGMQ+I++ DW+K+T+YRHYT+NSKQI  FW+ V+ + NE R+RLLQFVTGTCRLP+GGF+ L+GSNGPQKFCI+KVGKETWLPRSHTCFNRLDLPPYKS +QL EKL +AI+ETEGF  +
Sbjct:  285 QGTAAPAEPSPNATSNTEQSGTSTAEPNTDSLPTGWEQRVLPHGRVYYVDHNTKTTTWERP--LPAGWEKRVDQRGRFYYVDHNTRTTTWQRPTAESVRNYQQWQSQRSQLQGAMHQFSQRFLYQPSGAPV---------ENDPLGALPPGWEKRQD-NGRVYFVNHNTRTTQWDDPRTQGMIKEHPLPPGWEMKYTAEGVRYFVDHNSRTTTFKDPRPGFEPGSRQGGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNVKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLDKKPTLKDLESIDPEFYNSIMWVKENNLAECGVELYFAQDMEILGKVSTHQLKDDGENELVTEENKEEYISLLTDWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNTIYRHYTKNSKQIHWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFQELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSLEQLREKLLFAIEETEGFGQE 885
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000039114.1 (SMESG000039114.1)

HSP 1 Score: 1541.94 bits (3991), Expect = 0.000e+0
Identity = 737/738 (99.86%), Postives = 737/738 (99.86%), Query Frame = 1 
Query:  292 MDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            MDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESE CNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD
Sbjct:    1 MDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESELCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 738
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000008708.1 (SMESG000008708.1)

HSP 1 Score: 777.704 bits (2007), Expect = 0.000e+0
Identity = 395/797 (49.56%), Postives = 519/797 (65.12%), Query Frame = 1 
Query:  115 VKLKNLKILFNHKPSFFLDITLDNSQNHITSKKQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLKNMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILKFTVTAWPIKPLTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRTVNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRVATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            VK+KNL          +++ ++D++    T+ K +W P WS+E      + S I   L    +N    +   +    + L  +L +  G L+N  + V +  +N   ++     ++ ++LK   T                                      + I E D      +A+ T N   +            NS P  +S P      +   LP   ++ +PLPQ YE R    NR Y++D LTKT+SWE PQP+P GWERRLD H RVYYVDHNTR+TTWQRP+ +ML N+  +Q WR+ERNN M++   + YG  N      A N Q   D L  LP GWE+R DANNR Y+VNH N+TT W+DPR Q  PLP GWEIR+  DG  FF+DH TK +T+ DPR   +   E     K + F + CQ+   +GH+KI V R  L+ DSFN+IM+++P  L+KRL+I FK E+GLDYGG++REWFF+LS ELLNPM CLFEYA DNNYSL+INPASF+NPEHLQYFRFVGRF+AMA+FH KFIDSGFT+ FYK+ML K+  L+DIE VD  YYNSLKFI++ +++ECD+ L FSA++E+ GK+E QELK  G  I VTE+NK EYIDLMVNWRF+RG+  Q ++F+ GFNE++PL+WL  +DE++IELLLCGMQ I+V DWE +++YR YT++S QI  FW++V  L N+ ++RLLQFVTGTCRLP+GGF+ LMGSNGPQKFCIEK+GKE+WLPRSHTCFNRLDLPPY S++QL EKL YA+ ETEGF  +
Sbjct:   24 VKVKNL----GSHAELYVEYSVDDAPAKKTTTKSTWNPDWSEECNLLVEAKSSIKFIL----INNYKSQKKTLGKADVDLYKILCRFHGNLNNQELVVPISSTNSHTHI----GDLTVVLKIAST--------------------------------------INIPEEDR----PRANATGNLRGS-----------NNSLPVSDSSPA----LNRAVLPAADLSTDPLPQHYERRFDNFNRPYFVDHLTKTTSWEPPQPLPPGWERRLDTHNRVYYVDHNTRTTTWQRPDVSMLNNIDHFQRWRTERNNYMEQTLNQRYGAQNW-----AGNIQR-VDPLGALPQGWEKRTDANNRTYFVNHVNKTTHWDDPRLQANPLPPGWEIRFTEDGMAFFVDHETKTTTFTDPRTTPRTAEETQFLRKQSQFYYYCQNAVPEGHVKIIVRRNMLMEDSFNEIMRVKPKDLQKRLFIQFKDEDGLDYGGISREWFFQLSHELLNPMYCLFEYASDNNYSLQINPASFINPEHLQYFRFVGRFVAMAMFHRKFIDSGFTIPFYKKMLGKRITLQDIETVDVEYYNSLKFIRDNNIDECDMGLVFSAEYELFGKIEEQELKTNGRDIEVTEENKNEYIDLMVNWRFSRGVVEQTKAFMDGFNEIVPLHWLQVYDERQIELLLCGMQQIDVKDWEANSIYRVYTKDSPQIKWFWEFVGKLPNDEKIRLLQFVTGTCRLPVGGFRELMGSNGPQKFCIEKIGKESWLPRSHTCFNRLDLPPYASYEQLKEKLTYAVMETEGFGQE 745
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000038772.1 (SMESG000038772.1)

HSP 1 Score: 579.326 bits (1492), Expect = 0.000e+0
Identity = 287/558 (51.43%), Postives = 381/558 (68.28%), Query Frame = 1 
Query:  898 IPSGWERRLDGHGRVYYVDHNTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQE----AFARLYGT---DNALLPRVATNFQTDSDQLEPLPIGWERRVDA-NNRVYYVNHENRTTQWEDPRYQG----PPLPDGWEIRYNVDGKPFFIDHNTKISTYLDPRKF----------MKVDNEWDLSAKIATFRFLCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSMD 2505
            +P GWE R   +G++Y+ +      +W +P+ +M+ +V   ++ R    N + +     F+ +YG    DN  L R       D+D L   P GWE+R+D  NNRVYYVNH  + TQWEDPR  G      LP  WE+RY   G  +F+DH ++  T +DPR            + V  E     ++  F+  C+S    G +KIN  R DLL  SFNQI+ +  T L++RL I F GEEGLDYGGVA+EWF RLS E+LNPM CLFEYA   NYSLKINP SFVNP HL YF+F+GRFI MA FHG+ ID+GFT+ FYK++LNK   L+DIE++D  +Y SL FIKE  +N+CDLELYFSA +E+LG+++  EL PGG+ + VT++NK+EYI LM+ W   +G+E Q ++F++G  E++PL+ L  FDE+E+ELLLCG+Q I+VDDWE+HTVYR Y+ ++ Q+I FWK+VR+L +E + RLLQFVTGTCRLP+GGF  L G NG Q FC+E+VG ETWLPRSHTCFNRLDLPPYK+++Q  EKL  A +ETEGF  +
Sbjct:  162 LPEGWEMRNGENGQMYFYNEELNKRSWMKPSKSMINSV---RQLRVRTENRLSQHNKGLFSDIYGIFSKDNNSLIR------NDTDGL---PQGWEKRIDPRNNRVYYVNHITKMTQWEDPRLDGMNLNKKLPPNWEMRYTAKGIRYFVDHESQTVTLVDPRTGKQSGPVGSFGVPVLLERSFRYRLEAFQDECKSMMPTGTVKINFKRDDLLDSSFNQIINLSTTELKQRLSIQFLGEEGLDYGGVAKEWFLRLSHEILNPMYCLFEYANTYNYSLKINPGSFVNPNHLSYFKFIGRFIGMAFFHGRCIDNGFTIPFYKQILNKPLTLQDIESIDLEFYQSLLFIKENPINDCDLELYFSASYEVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYELVPLSLLQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVIWFWKFVRSLDHEQQARLLQFVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYKTYEQFIEKLTLAFEETEGFGQE 707

HSP 2 Score: 51.2174 bits (121), Expect = 3.440e-6
Identity = 25/71 (35.21%), Postives = 39/71 (54.93%), Query Frame = 1 
Query:  802 LPQFYEMR-RTKDNRIYYIDRLTKTSSWEKP--------QPIPSGWERRLDGHGRVYYVDHNTRSTTWQRP 987
            LPQ +E R   ++NR+YY++ +TK + WE P        + +P  WE R    G  Y+VDH +++ T   P
Sbjct:  240 LPQGWEKRIDPRNNRVYYVNHITKMTQWEDPRLDGMNLNKKLPPNWEMRYTAKGIRYFVDHESQTVTLVDP 310
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 451.44 bits (1160), Expect = 3.026e-144
Identity = 269/674 (39.91%), Postives = 368/674 (54.60%), Query Frame = 1 
Query:  733 SEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKP--QPIPSGWERRLDGHGRVYYVDHNTRSTTWQR------------------PNANMLTNVSLWQEWRSERNNNMQEA---------------FARLYGTDNALLPRV---------ATNFQTDSDQL------EPLPIGWERRVDANNRVYYVNHENRTTQWEDPRY-----------QGP-----------------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR--KFM--KVDNEWDLSAKIATFRF-LCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRK-RLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFV-NPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYR-HYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            S P  V++   T     +   E L   +E R  ++ RIYY+D  +K + WEKP    +P GWE R D  GRVYYVDH  + T W+                   P AN   +V      R   ++++  A                +R+       LP V           + +  + +L      E LP GW+  +  N R +++NH ++TT WEDPR              P                 PLP GWE R + DG+ FF++HNTK + + DPR  KF    V    +   K   FR  L      +   ++ ++RK++  DS+  I  ++ T + K +L+I F GE+GLDYGGV REWFF LS+E+ NP   LFEY+  +NY+L+INP S V N  HL+YF+F+GR   MA++HG+ +D  F    YK ML KK  L+D+E+VD  YY SLKFI E D     L+L FS D E  G+    +L P G S  VT++NK +YI+ ++NWRF + +E+Q  +F++GF +V+ LN L  FD  E+ELLLCG+QDINV DW+ +T Y+  Y  N   I++FWK V    NE+R RLLQFVTGT R+P+ GF  L GS GPQKF IEK G    LPR+HTCFNRLDLPPY +F++L  KL  AI+  EGF
Sbjct:  187 SIPGTVADSEITIHTEENSTAEVLANGWEERVDQNGRIYYVDHKSKRTQWEKPTNAQLPEGWEERADLSGRVYYVDHANQKTQWEHPASKSAPQKVNKLAKINMPAANNPLSVRAVSPTRPGPSSDVDAATMFLRRRQISHEDTVASRIRPVATESLPTVEQTTEPPPITASVENITKELASITVDEELPPGWQMAMTTNGRRFFINHNDKTTTWEDPRAIRNRSKSTSGTPAPTAINRTSSRDDLLVDLGPLPAGWEEREHTDGRIFFVNHNTKTTQWEDPRLNKFSGPAVPYSRNYKQKYDYFRSKLRAPREPNAKFEMRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFIGEKGLDYGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINPLSGVANENHLRYFKFIGRVAGMAVYHGRLLDGFFIRPLYKMMLGKKISLKDMESVDTEYYRSLKFILEND--PAVLDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQDINVTDWKGNTNYKGEYNPNHPVIVNFWKTVYTFNNELRSRLLQFVTGTSRVPMNGFVELWGSTGPQKFTIEKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGF 858
[Close]
BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 437.958 bits (1125), Expect = 1.119e-138
Identity = 271/714 (37.96%), Postives = 370/714 (51.82%), Query Frame = 1 
Query:  733 SEPCNVSECSSTALPINSVNDEPLPQFYEMRRTKDNRIYYIDRLTKTSSWEKP------------------------------QPI------------PSGWERRLDGHGRVYYVDHNTRSTTWQR------------------PNANMLTNVSLWQEWRSERNNNMQEA---------------FARLYGTDNALLPRV---------ATNFQTDSDQL------EPLPIGWERRVDANNRVYYVNHENRTTQWEDPRY-----------QGP-----------------PLPDGWEIRYNVDGKPFFIDHNTKISTYLDPR--KFM--KVDNEWDLSAKIATFRF-LCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRK-RLYITFKGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFV-NPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQDINVDDWEKHTVYR-HYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRLPIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGF 2496
            S P  V++   T     +   E L   +E R  ++ RIYY+D  +K + WEKP                              QP+            P GWE R D  GRVYYVDH  + T W+                   P AN   +V      R   ++++  A                +R+       LP V           + +  + +L      E LP GW+  +  N R +++NH ++TT WEDPR              P                 PLP GWE R + DG+ FF++HNTK + + DPR  KF    V    +   K   FR  L      +   ++ ++RK++  DS+  I  ++ T + K +L+I F GE+GLDYGGV REWFF LS+E+ NP   LFEY+  +NY+L+INP S V N  HL+YF+F+GR   MA++HG+ +D  F    YK ML KK  L+D+E+VD  YY SLKFI E D     L+L FS D E  G+    +L P G S  VT++NK +YI+ ++NWRF + +E+Q  +F++GF +V+ LN L  FD  E+ELLLCG+QDINV DW+ +T Y+  Y  N   I++FWK V    NE+R RLLQFVTGT R+P+ GF  L GS GPQKF IEK G    LPR+HTCFNRLDLPPY +F++L  KL  AI+  EGF
Sbjct:  187 SIPGTVADSEITIHTEENSTAEVLANGWEERVDQNGRIYYVDHKSKRTQWEKPTNFRVSKRPSNGSVLSNIDFTLLMSNPIRNQPLYDNEVCPNIAQLPEGWEERADLSGRVYYVDHANQKTQWEHPASKSAPQKVNKLAKINMPAANNPLSVRAVSPTRPGPSSDVDAATMFLRRRQISHEDTVASRIRPVATESLPTVEQTTEPPPITASVENITKELASITVDEELPPGWQMAMTTNGRRFFINHNDKTTTWEDPRAIRNRSKSTSGTPAPTAINRTSSRDDLLVDLGPLPAGWEEREHTDGRIFFVNHNTKTTQWEDPRLNKFSGPAVPYSRNYKQKYDYFRSKLRAPREPNAKFEMRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFIGEKGLDYGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINPLSGVANENHLRYFKFIGRVAGMAVYHGRLLDGFFIRPLYKMMLGKKISLKDMESVDTEYYRSLKFILEND--PAVLDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQDINVTDWKGNTNYKGEYNPNHPVIVNFWKTVYTFNNELRSRLLQFVTGTSRVPMNGFVELWGSTGPQKFTIEKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGF 898
The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-protein ligase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
WWP20.000e+047.32WW domain containing E3 ubiquitin protein ligase 2... [more]
ITCH0.000e+055.14itchy E3 ubiquitin protein ligase [Source:HGNC Sym... [more]
ITCH0.000e+055.14itchy E3 ubiquitin protein ligase [Source:HGNC Sym... [more]
ITCH0.000e+056.54itchy E3 ubiquitin protein ligase [Source:HGNC Sym... [more]
ITCH0.000e+056.54itchy E3 ubiquitin protein ligase [Source:HGNC Sym... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp-10.000e+060.34E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-10.000e+060.14E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-14.129e-861.14E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-14.129e-861.14E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-16.891e-860.90E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Su(dx)0.000e+057.92gene:FBgn0003557 transcript:FBtr0077823[more]
Su(dx)0.000e+057.92gene:FBgn0003557 transcript:FBtr0077824[more]
Su(dx)0.000e+057.92gene:FBgn0003557 transcript:FBtr0339529[more]
Su(dx)0.000e+057.92gene:FBgn0003557 transcript:FBtr0077822[more]
Su(dx)0.000e+057.92gene:FBgn0003557 transcript:FBtr0334778[more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp10.000e+058.32WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+058.32WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+058.32WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp14.224e-1159.90WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp15.228e-1159.90WW domain containing E3 ubiquitin protein ligase 1... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp10.000e+046.21WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+058.56WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+049.48WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+046.57WW domain containing E3 ubiquitin protein ligase 1... [more]
wwp10.000e+060.28WW domain containing E3 ubiquitin protein ligase 1... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Wwp14.366e-1459.39WW domain containing E3 ubiquitin protein ligase 1... [more]
Wwp14.366e-1459.39WW domain containing E3 ubiquitin protein ligase 1... [more]
Wwp20.000e+049.11WW domain containing E3 ubiquitin protein ligase 2... [more]
Wwp20.000e+055.42WW domain containing E3 ubiquitin protein ligase 2... [more]
Itch0.000e+057.74itchy, E3 ubiquitin protein ligase [Source:MGI Sym... [more]
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BLAST of E3 ubiquitin-protein ligase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BZZ3|WWP1_MOUSE3.054e-1359.39NEDD4-like E3 ubiquitin-protein ligase WWP1 OS=Mus... [more]
sp|O00308|WWP2_HUMAN0.000e+047.32NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Hom... [more]
sp|Q9DBH0|WWP2_MOUSE0.000e+055.42NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Mus... [more]
sp|Q96J02|ITCH_HUMAN0.000e+055.14E3 ubiquitin-protein ligase Itchy homolog OS=Homo ... [more]
sp|Q8C863|ITCH_MOUSE0.000e+057.74E3 ubiquitin-protein ligase Itchy OS=Mus musculus ... [more]
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BLAST of E3 ubiquitin-protein ligase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2T7NHA30.000e+049.53E3 ubiquitin-protein ligase OS=Pomacea canaliculat... [more]
A0A0B6YT330.000e+048.40E3 ubiquitin-protein ligase OS=Arion vulgaris OX=1... [more]
A0A210PNA00.000e+061.77E3 ubiquitin-protein ligase OS=Mizuhopecten yessoe... [more]
A0A2C9JU470.000e+062.01E3 ubiquitin-protein ligase OS=Biomphalaria glabra... [more]
A0A4W3IYB10.000e+061.16E3 ubiquitin-protein ligase OS=Callorhinchus milii... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp10.000e+060.31WW domain containing E3 ubiquitin protein ligase 1... [more]
itcha0.000e+058.49E3 ubiquitin-protein ligase Itchy-like [Source:NCB... [more]
itcha0.000e+058.49E3 ubiquitin-protein ligase Itchy-like [Source:NCB... [more]
itchb0.000e+057.78E3 ubiquitin-protein ligase Itchy [Source:NCBI gen... [more]
itchb1.889e-858.26E3 ubiquitin-protein ligase Itchy [Source:NCBI gen... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp20.000e+050.24WW domain containing E3 ubiquitin protein ligase 2... [more]
nedd4a8.666e-13647.45NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A... [more]
smurf23.147e-11136.22SMAD specific E3 ubiquitin protein ligase 2 [Sourc... [more]
ENSPMAT00000005015.11.998e-5350.00pep scaffold:Pmarinus_7.0:GL486731:734:6293:1 gene... [more]
AREL17.072e-5034.57apoptosis resistant E3 ubiquitin protein ligase 1 ... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
RSP51.701e-14539.83NEDD4 family E3 ubiquitin ligase; regulates proces... [more]
TOM12.728e-7439.39E3 ubiquitin ligase of the hect-domain class; has ... [more]
HUL45.210e-3529.18Protein with similarity to hect domain E3 ubiquiti... [more]
HUL57.356e-3528.16Multiubiquitin chain assembly factor (E4); proteas... [more]
UFD41.626e-2229.77Ubiquitin-protein ligase (E3); interacts with Rpt4... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO493280.000e+058.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493270.000e+068.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO460713.914e-13140.39Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493832.053e-10046.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO302683.615e-5235.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wwp10.000e+059.80WW domain containing E3 ubiquitin protein ligase 1... [more]
itcha0.000e+058.87E3 ubiquitin-protein ligase Itchy [Source:NCBI gen... [more]
itcha0.000e+058.87E3 ubiquitin-protein ligase Itchy [Source:NCBI gen... [more]
itchb0.000e+057.48E3 ubiquitin-protein ligase Itchy [Source:NCBI gen... [more]
wwp20.000e+056.77WW domain containing E3 ubiquitin protein ligase 2... [more]
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BLAST of E3 ubiquitin-protein ligase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000039114.10.000e+099.86SMESG000039114.1[more]
SMESG000008708.10.000e+049.56SMESG000008708.1[more]
SMESG000038772.13.440e-651.43SMESG000038772.1[more]
SMESG000013095.13.026e-14439.91SMESG000013095.1[more]
SMESG000013095.11.119e-13837.96SMESG000013095.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013730 ID=SMED30013730|Name=E3 ubiquitin-protein ligase|organism=Schmidtea mediterranea sexual|type=transcript|length=2911bp
GAAATATTTTATTTATTATTTATGAGTTAATATTTATGAATCATATTTAA
TTTAATAATGACAAACTTAAATGATCAGTCAAATGATTTCTCAATTAAGC
TACATTTTAATGTTGTAAAATTGAAAAATCTAAAAATCCTTTTTAATCAT
AAACCTTCGTTTTTTTTGGATATTACATTGGATAATTCCCAAAATCACAT
AACTTCTAAAAAACAGTCTTGGTGTCCTTCATGGAGTGATGAGTTTGTCT
TTAATGGAAATAGTAATTCCAAAATAAACATTTATTTAAAAATGGATCAT
GTCAATGGAATGACTTTTGAAAATTCAGTTGTTGCTATGTGCACATTAAC
TCTGAAGAATATGTTACAAAAAGCCGGTGGAAAACTTGATAATACTTACA
TGGCTGTGGTATTGAAAAAATCAAATGAATTACAGAATATGTTGCAAAAT
TATTGCAATATGGAACTGATATTGAAATTTACAGTGACGGCTTGGCCCAT
TAAACCTTTAACGAAAAATAATGCTAGTAAACGGTCCTCATTAATCATTG
GCCAAGGTACTTCAAATAGTGAGTTTCATGACGTTGAAACCGCTATATCT
GACGTAACAATCTCTGAAAGAGATACAATTGAAACTCTCAGTAAAGCTTC
CAGAACTGTAAATTCCGATACTGCAATTAGTATTGAAAACAACTTTTCTA
AATTAATTCAAAATTCTCAGCCACCTCCAGAATCAGAACCATGTAATGTA
TCCGAGTGCTCTAGTACTGCATTACCAATCAATTCTGTAAATGATGAACC
TCTACCTCAATTCTATGAAATGAGGCGAACTAAAGATAATCGAATATATT
ACATCGATCGTTTGACGAAGACAAGTTCTTGGGAGAAACCTCAACCAATA
CCATCTGGTTGGGAAAGACGCCTGGACGGTCATGGCCGCGTTTATTACGT
TGATCACAATACTCGTAGTACTACTTGGCAGCGTCCTAATGCCAATATGT
TAACAAATGTCAGCCTGTGGCAGGAATGGAGGTCTGAGCGTAATAATAAC
ATGCAAGAAGCATTTGCAAGGCTTTACGGCACTGATAATGCTTTGCTTCC
TAGGGTAGCTACTAACTTTCAGACCGATAGCGATCAACTTGAACCACTGC
CAATCGGATGGGAAAGAAGAGTTGATGCTAATAATCGAGTTTATTACGTA
AACCATGAAAACAGAACAACCCAATGGGAAGATCCTAGATATCAGGGTCC
TCCATTACCCGATGGTTGGGAAATTCGGTATAATGTTGACGGGAAACCGT
TTTTCATCGACCACAACACAAAGATCTCAACATATTTAGATCCTAGAAAG
TTTATGAAAGTGGATAATGAATGGGATTTAAGCGCTAAAATCGCAACCTT
TAGATTTTTGTGCCAATCAAACGGTGTTGATGGGCATATTAAAATCAATG
TATCCAGAAAAGATCTACTCACTGATTCCTTCAATCAGATAATGCAAATC
CAGCCGACTCATTTGCGCAAAAGATTATATATCACTTTCAAAGGTGAAGA
AGGTCTGGATTATGGAGGCGTTGCCAGAGAGTGGTTTTTTCGATTATCCC
AAGAACTTCTCAATCCAATGATTTGCCTATTCGAATATGCTTGTGATAAT
AATTATTCTCTCAAAATTAATCCCGCGTCTTTCGTCAATCCTGAACATTT
GCAATATTTTAGATTCGTTGGTCGATTTATCGCAATGGCTTTATTTCACG
GTAAATTCATAGACAGTGGGTTTACTCTGTCATTTTACAAACGGATGCTC
AACAAAAAACCCATTCTAGAAGACATTGAAGCCGTTGATTATCTTTATTA
CAATTCTCTTAAATTTATCAAAGAAATGGATTTGAATGAGTGTGACTTGG
AATTGTATTTCTCGGCTGACTTTGAGATTTTAGGGAAATTGGAAACCCAA
GAATTGAAACCAGGTGGACATTCAATCTTAGTCACCGAAGACAATAAAGA
GGAATATATTGACCTTATGGTCAATTGGAGATTCAATAGAGGCATTGAAA
ATCAAGCTGAATCTTTCATCAAAGGATTCAATGAAGTTTTACCTTTAAAT
TGGCTTTATTATTTTGATGAAAAGGAAATTGAACTCCTGTTATGCGGTAT
GCAAGACATCAACGTCGATGATTGGGAAAAGCATACAGTTTATAGGCATT
ATACTCAGAATAGCAAACAGATTATTCACTTTTGGAAGTATGTACGCAAT
TTAACAAACGAAATGAGAGTAAGACTTCTTCAATTTGTTACTGGAACATG
CCGTCTGCCAATTGGAGGTTTCAAAAATTTGATGGGCAGCAATGGGCCCC
AAAAGTTTTGTATAGAGAAAGTTGGTAAAGAAACCTGGCTACCTCGCAGT
CATACGTGTTTCAACAGATTAGATTTGCCGCCATATAAAAGCTTTCAACA
GTTGTCAGAGAAATTGAACTATGCTATTAAAGAAACAGAGGGATTCAGTA
TGGACTAATAGAAAGGATTTGTACTAATCAGTACTCCTTACCAACTAATT
CTGGACTTATTTTACTCCTATTAAAAATTCATATTTTTAATATTATGATG
TTTTTTTTGTTAAATTAAACGAGTTTTTTCCATTTATCTGAAATATGAAG
ATTATTCAGTTGTGCTCGTTGGAAATTTCGACTGAGAAATTTCTATCTTT
ACAGTGATTTTAGTTGAAATGTTTTTCCAGGAATCTTTCTTGGATTTTTG
TTCAAGCTGAGTGGTGGGTTTAGAATTTGATTAGTTTGGTTTACCTCTCA
ATCAGTTCTCTTGTTTTGTGTGTTTTTTCTGATTTTACAATTTTTGTAAC
TAATTTCAATTGATGATGTAATATTTTTTATTTAAAAAAAAGTTAAAAAT
TCTGAAAAAAA
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protein sequence of SMED30013730-orf-1

>SMED30013730-orf-1 ID=SMED30013730-orf-1|Name=SMED30013730-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=817bp
MTNLNDQSNDFSIKLHFNVVKLKNLKILFNHKPSFFLDITLDNSQNHITS
KKQSWCPSWSDEFVFNGNSNSKINIYLKMDHVNGMTFENSVVAMCTLTLK
NMLQKAGGKLDNTYMAVVLKKSNELQNMLQNYCNMELILKFTVTAWPIKP
LTKNNASKRSSLIIGQGTSNSEFHDVETAISDVTISERDTIETLSKASRT
VNSDTAISIENNFSKLIQNSQPPPESEPCNVSECSSTALPINSVNDEPLP
QFYEMRRTKDNRIYYIDRLTKTSSWEKPQPIPSGWERRLDGHGRVYYVDH
NTRSTTWQRPNANMLTNVSLWQEWRSERNNNMQEAFARLYGTDNALLPRV
ATNFQTDSDQLEPLPIGWERRVDANNRVYYVNHENRTTQWEDPRYQGPPL
PDGWEIRYNVDGKPFFIDHNTKISTYLDPRKFMKVDNEWDLSAKIATFRF
LCQSNGVDGHIKINVSRKDLLTDSFNQIMQIQPTHLRKRLYITFKGEEGL
DYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPASFVNPEHLQY
FRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKKPILEDIEAVDYLYYNS
LKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEY
IDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQD
INVDDWEKHTVYRHYTQNSKQIIHFWKYVRNLTNEMRVRLLQFVTGTCRL
PIGGFKNLMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSFQQLS
EKLNYAIKETEGFSMD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006511ubiquitin-dependent protein catabolic process
GO:0019915lipid storage
GO:0031623receptor internalization
GO:0032880regulation of protein localization
GO:0035209pupal development
GO:0045746negative regulation of Notch signaling pathway
GO:0048190wing disc dorsal/ventral pattern formation
GO:0007219Notch signaling pathway
GO:0007275multicellular organism development
GO:0008586imaginal disc-derived wing vein morphogenesis
GO:0008587imaginal disc-derived wing margin morphogenesis
GO:0016348imaginal disc-derived leg joint morphogenesis
GO:0016567protein ubiquitination
Vocabulary: molecular function
TermDefinition
GO:0061630ubiquitin protein ligase activity
GO:0005515protein binding
GO:0004842ubiquitin-protein transferase activity
GO:0019904protein domain specific binding
GO:0005112Notch binding
GO:0016740transferase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR035892C2_domain_sf
IPR024928E3_ub_ligase_SMURF1
IPR036020WW_dom_sf
IPR035983Hect_E3_ubiquitin_ligase
IPR001202WW_dom
IPR000569HECT_dom
IPR000008C2_dom
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005938cell cortex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000569HECT domainSMARTSM00119hect_3coord: 480..816
e-value: 1.2E-161
score: 553.0
IPR000569HECT domainPFAMPF00632HECTcoord: 513..815
e-value: 1.2E-92
score: 310.8
IPR000569HECT domainPROSITEPS50237HECTcoord: 482..816
score: 104.124
IPR000569HECT domainCDDcd00078HECTccoord: 461..814
e-value: 4.35762E-158
score: 462.42
IPR001202WW domainSMARTSM00456ww_5coord: 282..312
e-value: 9.7E-9
score: 45.0
coord: 399..431
e-value: 4.3E-9
score: 46.2
coord: 363..395
e-value: 6.3E-12
score: 55.6
coord: 248..280
e-value: 1.9E-6
score: 37.5
IPR001202WW domainPFAMPF00397WWcoord: 400..429
e-value: 1.3E-6
score: 28.4
coord: 282..310
e-value: 1.9E-10
score: 40.7
coord: 364..393
e-value: 4.0E-12
score: 46.0
coord: 254..278
e-value: 3.1E-6
score: 27.2
IPR001202WW domainPROSITEPS01159WW_DOMAIN_1coord: 285..310
IPR001202WW domainPROSITEPS01159WW_DOMAIN_1coord: 404..429
IPR001202WW domainPROSITEPS01159WW_DOMAIN_1coord: 368..393
IPR001202WW domainPROSITEPS50020WW_DOMAIN_2coord: 362..395
score: 18.559
IPR001202WW domainPROSITEPS50020WW_DOMAIN_2coord: 398..431
score: 14.836
IPR001202WW domainPROSITEPS50020WW_DOMAIN_2coord: 247..280
score: 13.004
IPR001202WW domainPROSITEPS50020WW_DOMAIN_2coord: 279..312
score: 18.264
IPR001202WW domainCDDcd00201WWcoord: 254..280
e-value: 2.47162E-6
score: 42.515
IPR001202WW domainCDDcd00201WWcoord: 367..394
e-value: 8.72644E-12
score: 57.923
IPR001202WW domainCDDcd00201WWcoord: 282..310
e-value: 2.10983E-10
score: 54.071
IPR001202WW domainCDDcd00201WWcoord: 401..430
e-value: 1.93571E-8
score: 48.6782
IPR035892C2 domain superfamilyGENE3DG3DSA:2.60.40.150coord: 12..145
e-value: 4.0E-7
score: 32.0
NoneNo IPR availableGENE3DG3DSA:3.30.2410.10coord: 697..816
e-value: 2.5E-46
score: 158.5
NoneNo IPR availableGENE3DG3DSA:2.20.70.10coord: 281..322
e-value: 4.5E-14
score: 53.9
NoneNo IPR availableGENE3DG3DSA:2.20.70.10coord: 241..280
e-value: 2.2E-10
score: 42.0
NoneNo IPR availableGENE3DG3DSA:2.20.70.10coord: 355..394
e-value: 8.6E-18
score: 66.0
NoneNo IPR availableGENE3DG3DSA:3.30.2160.10coord: 584..662
e-value: 6.2E-122
score: 408.3
NoneNo IPR availableGENE3DG3DSA:3.90.1750.10coord: 399..695
e-value: 6.2E-122
score: 408.3
NoneNo IPR availablePANTHERPTHR11254:SF299NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1coord: 179..814
NoneNo IPR availablePANTHERPTHR11254HECT DOMAIN UBIQUITIN-PROTEIN LIGASEcoord: 179..814
NoneNo IPR availableSUPERFAMILYSSF49562C2 domain (Calcium/lipid-binding domain, CaLB)coord: 11..114
IPR024928E3 ubiquitin-protein ligase, SMURF1 typePIRSFPIRSF001569E3_ub_ligase_SMURF1coord: 278..816
e-value: 1.1E-224
score: 746.1
coord: 1..281
e-value: 1.0E-11
score: 41.5
IPR036020WW domain superfamilySUPERFAMILYSSF51045WW domaincoord: 243..279
IPR036020WW domain superfamilySUPERFAMILYSSF51045WW domaincoord: 280..312
IPR036020WW domain superfamilySUPERFAMILYSSF51045WW domaincoord: 398..432
IPR036020WW domain superfamilySUPERFAMILYSSF51045WW domaincoord: 356..396
IPR035983HECT, E3 ligase catalytic domainSUPERFAMILYSSF56204Hect, E3 ligase catalytic domaincoord: 445..810