Insulin gene enhancer protein isl-1

Overview
NameInsulin gene enhancer protein isl-1
Smed IDSMED30013688
Length (bp)1229
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Insulin gene enhancer protein isl-1 (SMED30013688) t-SNE clustered cells

Violin plots show distribution of expression levels for Insulin gene enhancer protein isl-1 (SMED30013688) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Insulin gene enhancer protein isl-1 (SMED30013688) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Insulin gene enhancer protein isl-1 (SMED30013688) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013688

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30013688h1SMcG0000008 SmedASXL_003734SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30013688h1SMcG0000008 dd_Smed_v4_35379_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30013688h1SMcG0000008 dd_Smed_v4_35379_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30013688h1SMcG0000008 dd_Smed_v4_35379_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Match: ISL2 (ISL LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18524])

HSP 1 Score: 98.2117 bits (243), Expect = 4.344e-22
Identity = 59/147 (40.14%), Postives = 86/147 (58.50%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ +E  ++   +E++  Y  P     EF  ++  ++  F  ++S
Sbjct:  180 LRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTP--LVAGSPIRHENAVQGSAVEVQ-TYQPPWKALSEFALQSDLDQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Match: ISL1 (ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132])

HSP 1 Score: 93.9745 bits (232), Expect = 8.699e-21
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Match: ISL1 (ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132])

HSP 1 Score: 93.9745 bits (232), Expect = 1.020e-20
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Match: LHX3 (LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595])

HSP 1 Score: 64.6994 bits (156), Expect = 9.310e-11
Identity = 30/58 (51.72%), Postives = 39/58 (67.24%), Query Frame = 3 
Query:  690 APRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            A R RT ++ KQL TL++ Y  +PKP    +EQL   TGL  RV+ VWFQN+R KEK+
Sbjct:  162 AKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 219
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Match: LHX3 (LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595])

HSP 1 Score: 64.6994 bits (156), Expect = 9.572e-11
Identity = 30/58 (51.72%), Postives = 39/58 (67.24%), Query Frame = 3 
Query:  690 APRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            A R RT ++ KQL TL++ Y  +PKP    +EQL   TGL  RV+ VWFQN+R KEK+
Sbjct:  157 AKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 214
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Match: lim-7 (CeLIM-7; LIM domain family [Source:UniProtKB/TrEMBL;Acc:G5EC36])

HSP 1 Score: 84.3445 bits (207), Expect = 1.503e-17
Identity = 58/173 (33.53%), Postives = 89/173 (51.45%), Query Frame = 3 
Query:  675 KTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRIS-----------EELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERV-------------YNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAV 1121
            K  K+A R RTVL+E QL  L+  Y +N +PDA  KE+L+E+TGL  RVI VWFQNKRCK+KKR+I            E LN+ ++ G+     LM+  +    +      I+I+               Y NP  F+  ++++    + +L+   P+++  S    PL  +V
Sbjct:  260 KKDKQATRVRTVLNENQLKILRDCYSINSRPDATLKERLVEMTGLSARVIRVWFQNKRCKDKKRQIQITENRLNSEREEVLNRVRVNGI---GPLMVQPATPHIDNTLGGPIDIQHFAQWNGTPPPPPPQYGNPMMFNSPSTFD---VSVILAPVAPNVTSPSEALGPLGASV 426

HSP 2 Score: 50.8322 bits (120), Expect = 2.680e-10
Identity = 22/71 (30.99%), Postives = 36/71 (50.70%), Query Frame = 1 
Query:   43 ICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSL 255
            +C  C   I  +  +++ P++  H  CL+C QC   L  + + F+K G+ +C   YR LF   C  C+G  
Sbjct:   55 VCAGCRLEISDRYFLRVNPNLEFHAQCLKCVQCSRPLDENQTAFVKNGQTYCRDDYRRLFTTRCSRCHGDF 125

HSP 3 Score: 32.7278 bits (73), Expect = 2.680e-10
Identity = 17/51 (33.33%), Postives = 26/51 (50.98%), Query Frame = 3 
Query:  249 EFVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVIC-TDCQ 398
            +F  TD V+     +  H  C  C AC K L +G ++ I   S+ C +DC+
Sbjct:  124 DFDKTDLVMRAGPQNVFHLNCFACVACEKRLQTGEEFQIKNNSLYCRSDCR 174
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Match: lim-4 (LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0A1X7RC92])

HSP 1 Score: 62.3882 bits (150), Expect = 1.687e-10
Identity = 27/59 (45.76%), Postives = 37/59 (62.71%), Query Frame = 3 
Query:  687 KAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            K  R RT  +E QLS LQT++  +  PD    E++  +TGL +RV  VWFQN R ++KK
Sbjct:  238 KTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKK 296
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Match: lim-4 (LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0A1X7RC92])

HSP 1 Score: 62.3882 bits (150), Expect = 1.688e-10
Identity = 27/59 (45.76%), Postives = 37/59 (62.71%), Query Frame = 3 
Query:  687 KAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            K  R RT  +E QLS LQT++  +  PD    E++  +TGL +RV  VWFQN R ++KK
Sbjct:  227 KTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKK 285
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Match: lim-4 (LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0A1X7RC92])

HSP 1 Score: 62.3882 bits (150), Expect = 1.768e-10
Identity = 27/59 (45.76%), Postives = 37/59 (62.71%), Query Frame = 3 
Query:  687 KAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            K  R RT  +E QLS LQT++  +  PD    E++  +TGL +RV  VWFQN R ++KK
Sbjct:  229 KTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKK 287
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Match: ceh-45 (C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:Q9N4L2])

HSP 1 Score: 58.5362 bits (140), Expect = 2.526e-10
Identity = 27/68 (39.71%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  666 HSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRR 869
            H    S++  R+RT+ SE+QL+ L+T +     PDA T+E+L     LK+  + VWF+N+R KE+K++
Sbjct:   16 HQHYASRRKRRHRTIFSEEQLNILETTFSTTHYPDATTREELAVQCSLKEERVEVWFKNRRAKERKQK 83
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Match: tup (gene:FBgn0003896 transcript:FBtr0081112)

HSP 1 Score: 97.4413 bits (241), Expect = 1.058e-21
Identity = 53/110 (48.18%), Postives = 70/110 (63.64%), Query Frame = 3 
Query:  678 TSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELN------KNKLPGMLSKAELMLTESPVEYE-PLELPGIEIE 986
            +  K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+T L  RVI VWFQNKRCK+KK+ I  +L         KL     +   M+  SPV ++ PL L G++++
Sbjct:  237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQ 346
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Match: tup (gene:FBgn0003896 transcript:FBtr0081111)

HSP 1 Score: 97.0561 bits (240), Expect = 1.733e-21
Identity = 55/116 (47.41%), Postives = 72/116 (62.07%), Query Frame = 3 
Query:  678 TSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELN------KNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP 1004
            +  K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+T L  RVI VWFQNKRCK+KK+ I  +L         KL     +   M+  SPV ++ PL L G++++  Y  P
Sbjct:  237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQ-TYQPP 351
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Match: tup (gene:FBgn0003896 transcript:FBtr0342921)

HSP 1 Score: 97.0561 bits (240), Expect = 1.733e-21
Identity = 55/116 (47.41%), Postives = 72/116 (62.07%), Query Frame = 3 
Query:  678 TSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELN------KNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP 1004
            +  K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+T L  RVI VWFQNKRCK+KK+ I  +L         KL     +   M+  SPV ++ PL L G++++  Y  P
Sbjct:  237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQ-TYQPP 351
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Match: Lim3 (gene:FBgn0002023 transcript:FBtr0309834)

HSP 1 Score: 68.1662 bits (165), Expect = 3.844e-12
Identity = 33/67 (49.25%), Postives = 43/67 (64.18%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            D SL   +   R RT ++ KQL TL+T Y  +PKP    +EQL + TGL  RV+ VWFQN+R KEK+
Sbjct:  132 DGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKR 198
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Match: Lim3 (gene:FBgn0002023 transcript:FBtr0081169)

HSP 1 Score: 68.1662 bits (165), Expect = 4.223e-12
Identity = 33/67 (49.25%), Postives = 43/67 (64.18%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            D SL   +   R RT ++ KQL TL+T Y  +PKP    +EQL + TGL  RV+ VWFQN+R KEK+
Sbjct:  247 DGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKR 313
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Match: isl2b (ISL LIM homeobox 2b [Source:NCBI gene;Acc:30151])

HSP 1 Score: 107.071 bits (266), Expect = 1.866e-25
Identity = 63/144 (43.75%), Postives = 87/144 (60.42%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI------SEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIE-RVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I       +  +K  L GM   A  ++  SP+ + P  +PG  ++ + Y  P     EF  ++  ++  F  ++S
Sbjct:  182 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQLQQQHGDKTNLQGMTGTA--LVAGSPIRHNP-SVPGHPVDVQAYQPPWKALSEFALQSDLDQPAFQQLVS 322
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Match: isl1l (islet1, like [Source:ZFIN;Acc:ZDB-GENE-040624-1])

HSP 1 Score: 101.293 bits (251), Expect = 1.147e-23
Identity = 59/129 (45.74%), Postives = 76/129 (58.91%), Query Frame = 3 
Query:  675 KTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLS 1061
            + S++A R RTVLSE QL  LQT Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR ++    + +L G L   E +L  S    +      + I   +    +F  EN  E + F  MLS
Sbjct:  167 RCSERATRVRTVLSETQLCMLQTCYTANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSLTMRHTQKQLEGHLVSEEPLLLVSTESQD----SDVMISPPWKLLTDFILENEAEHRSFPQMLS 291

HSP 2 Score: 44.669 bits (104), Expect = 2.834e-9
Identity = 23/72 (31.94%), Postives = 34/72 (47.22%), Query Frame = 1 
Query:   28 IKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRIC 243
             K +  C  C   I  +  +++ PD+  H  CL+C +C   L    +CFI+ G+ FC  HY  L    C  C
Sbjct:   13 TKLSSFCVGCGLEILDRFILRVSPDLEWHARCLKCAECHQFLDESCTCFIRDGKTFCREHYSRLSTSKCAKC 84

HSP 3 Score: 36.5798 bits (83), Expect = 2.834e-9
Identity = 16/47 (34.04%), Postives = 27/47 (57.45%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTD 392
            F++ +FV+    + Y H QC  C  C +PL  G +Y + +  ++CTD
Sbjct:   88 FISKEFVMRSQVNIY-HIQCFRCEGCNRPLLPGDEYVLQDGQLLCTD 133
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Match: isl1l (islet1, like [Source:ZFIN;Acc:ZDB-GENE-040624-1])

HSP 1 Score: 100.523 bits (249), Expect = 2.748e-23
Identity = 58/130 (44.62%), Postives = 79/130 (60.77%), Query Frame = 3 
Query:  675 KTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPG-MLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLS 1061
            + S++A R RTVLSE QL  LQT Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR ++    + +L G ++SK  L+L  +  +        + I   +    +F  +N  E + F  MLS
Sbjct:  167 RRSERATRVRTVLSETQLCMLQTCYTANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSLTMRHTQKQLEGHLVSKEPLLLVSTESQDS-----DVMISPPWKLLTDFILQNEAEHRSFPQMLS 291

HSP 2 Score: 43.8986 bits (102), Expect = 2.699e-9
Identity = 23/72 (31.94%), Postives = 34/72 (47.22%), Query Frame = 1 
Query:   28 IKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRIC 243
             K +  C  C   I  +  +++ PD+  H  CL+C +C   L    +CFI+ G+ FC  HY  L    C  C
Sbjct:   13 TKLSSFCVGCGLEILDRFILRVSPDLEWHARCLKCAECHQFLDESCTCFIRDGKTFCREHYSRLSSSKCAKC 84

HSP 3 Score: 36.965 bits (84), Expect = 2.699e-9
Identity = 16/47 (34.04%), Postives = 28/47 (59.57%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTD 392
            F++ +FV+    + Y H QC  C +C +PL  G +Y + +  ++CTD
Sbjct:   88 FISKEFVMHSQVNIY-HVQCFRCESCNRPLLPGDEYVLQDGQLLCTD 133
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Match: isl2a (ISL LIM homeobox 2a [Source:NCBI gene;Acc:30157])

HSP 1 Score: 95.5153 bits (236), Expect = 2.175e-21
Identity = 59/145 (40.69%), Postives = 85/145 (58.62%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIE-RVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ ++   + G  +E + Y  P     EF  ++  ++  F  ++S
Sbjct:  182 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHNDKTNLQGLTGTP--LVAGSPIRHD-TTVQGNPVEVQTYQPPWKALSEFALQSDLDQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Match: isl1 (ISL LIM homeobox 1 [Source:NCBI gene;Acc:30147])

HSP 1 Score: 93.9745 bits (232), Expect = 7.789e-21
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Match: isl2 (ISL LIM homeobox 2 [Source:NCBI gene;Acc:100306962])

HSP 1 Score: 97.0561 bits (240), Expect = 6.580e-22
Identity = 58/149 (38.93%), Postives = 88/149 (59.06%), Query Frame = 3 
Query:  651 NNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEEL-------NKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            ++L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I  +        +K  L G+      M+  SP+ ++  ++   +E++  Y  P     +F  ++  ++  F  ++S
Sbjct:  152 SSLRSHIHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQLNDKTSLQGLTGTP--MVAGSPIRHDSAVQGSAVEVQ-TYQPPWKALSDFALQSDLDQPAFQQLVS 297
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Match: isl2 (ISL LIM homeobox 2 [Source:NCBI gene;Acc:100306962])

HSP 1 Score: 97.0561 bits (240), Expect = 8.314e-22
Identity = 58/149 (38.93%), Postives = 88/149 (59.06%), Query Frame = 3 
Query:  651 NNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEEL-------NKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            ++L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I  +        +K  L G+      M+  SP+ ++  ++   +E++  Y  P     +F  ++  ++  F  ++S
Sbjct:  172 SSLRSHIHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQLNDKTSLQGLTGTP--MVAGSPIRHDSAVQGSAVEVQ-TYQPPWKALSDFALQSDLDQPAFQQLVS 317
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Match: ISL1 (ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132])

HSP 1 Score: 93.9745 bits (232), Expect = 1.028e-20
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Match: ISL1 (ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132])

HSP 1 Score: 93.5893 bits (231), Expect = 1.175e-20
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Match: gfm2 (G elongation factor, mitochondrial 2 [Source:Xenbase;Acc:XB-GENE-1002407])

HSP 1 Score: 64.3142 bits (155), Expect = 9.918e-11
Identity = 42/132 (31.82%), Postives = 61/132 (46.21%), Query Frame = 3 
Query:  651 NNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYF 1046
            N   D +L   ++ PR  T +  KQL TL+  +   PKP    +EQL + TGL  RVI VWFQN+R KE++ +    L   +              SP    PL       E + N P  F+ +  Y+ +Y+
Sbjct:  165 NENDDQNLGAKRRGPR--TTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR---------HAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGD--YQSEYY 283
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Match: Isl2 (insulin related protein 2 (islet 2) [Source:MGI Symbol;Acc:MGI:109156])

HSP 1 Score: 98.2117 bits (243), Expect = 2.555e-22
Identity = 59/148 (39.86%), Postives = 87/148 (58.78%), Query Frame = 3 
Query:  654 NLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ +E  ++   +E++  Y  P     EF  ++  ++  F  ++S
Sbjct:  179 SLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTP--LVAGSPIRHENAVQGSAVEVQ-TYQPPWKALSEFALQSDLDQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Match: Isl1 (ISL1 transcription factor, LIM/homeodomain [Source:MGI Symbol;Acc:MGI:101791])

HSP 1 Score: 93.9745 bits (232), Expect = 5.972e-21
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Match: Isl1 (ISL1 transcription factor, LIM/homeodomain [Source:MGI Symbol;Acc:MGI:101791])

HSP 1 Score: 93.9745 bits (232), Expect = 7.003e-21
Identity = 47/72 (65.28%), Postives = 54/72 (75.00%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 241
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Match: Lhx1 (LIM homeobox protein 1 [Source:MGI Symbol;Acc:MGI:99783])

HSP 1 Score: 64.6994 bits (156), Expect = 3.776e-11
Identity = 31/73 (42.47%), Postives = 43/73 (58.90%), Query Frame = 3 
Query:  651 NNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRR 869
            N   D +L   ++ PR  T +  KQL TL+  +   PKP    +EQL + TGL  RVI VWFQN+R KE++ +
Sbjct:   78 NENDDQNLGAKRRGPR--TTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK 148
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Match: Lhx4 (LIM homeobox protein 4 [Source:MGI Symbol;Acc:MGI:101776])

HSP 1 Score: 63.5438 bits (153), Expect = 3.968e-11
Identity = 30/58 (51.72%), Postives = 39/58 (67.24%), Query Frame = 3 
Query:  690 APRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            A R RT ++ KQL TL+  Y+ +PKP    +EQL   TGL  RV+ VWFQN+R KEK+
Sbjct:   96 AKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 153
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Match: sp|P53407|ISL2B_DANRE (Insulin gene enhancer protein isl-2b OS=Danio rerio OX=7955 GN=isl2b PE=2 SV=1)

HSP 1 Score: 107.071 bits (266), Expect = 1.408e-24
Identity = 63/144 (43.75%), Postives = 87/144 (60.42%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI------SEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIE-RVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I       +  +K  L GM   A  ++  SP+ + P  +PG  ++ + Y  P     EF  ++  ++  F  ++S
Sbjct:  182 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQLQQQHGDKTNLQGMTGTA--LVAGSPIRHNP-SVPGHPVDVQAYQPPWKALSEFALQSDLDQPAFQQLVS 322
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Match: sp|P50212|ISL2B_ONCTS (Insulin gene enhancer protein ISL-2B (Fragment) OS=Oncorhynchus tshawytscha OX=74940 GN=isl2b PE=2 SV=1)

HSP 1 Score: 100.908 bits (250), Expect = 1.911e-22
Identity = 60/144 (41.67%), Postives = 82/144 (56.94%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I          ++K  L G+      M+  SP+ ++   L      + Y  P     EF  ++  ++  F  ++S
Sbjct:  163 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRTIFMKQLQQQHHIDKTNLQGLTGTP--MVAGSPIRHDNTVLGNPVEVQTYQPPWKALSEFALQSDLDQPAFRQLVS 304
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Match: sp|P50480|ISL2_RAT (Insulin gene enhancer protein ISL-2 OS=Rattus norvegicus OX=10116 GN=Isl2 PE=1 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 7.720e-22
Identity = 60/148 (40.54%), Postives = 87/148 (58.78%), Query Frame = 3 
Query:  654 NLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+     L++  SP  +E  ++   +E++  Y  P     EF  ++  ++  F  ++S
Sbjct:  180 SLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGL--TGTLLVAGSPSAHENAVQGSAVEVQ-TYQPPWKALSEFALQSDLDQPAFQQLVS 324
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Match: sp|Q9CXV0|ISL2_MOUSE (Insulin gene enhancer protein ISL-2 OS=Mus musculus OX=10090 GN=Isl2 PE=1 SV=2)

HSP 1 Score: 98.2117 bits (243), Expect = 1.787e-21
Identity = 59/148 (39.86%), Postives = 87/148 (58.78%), Query Frame = 3 
Query:  654 NLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ +E  ++   +E++  Y  P     EF  ++  ++  F  ++S
Sbjct:  179 SLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTP--LVAGSPIRHENAVQGSAVEVQ-TYQPPWKALSEFALQSDLDQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Match: sp|Q96A47|ISL2_HUMAN (Insulin gene enhancer protein ISL-2 OS=Homo sapiens OX=9606 GN=ISL2 PE=1 SV=1)

HSP 1 Score: 98.2117 bits (243), Expect = 2.086e-21
Identity = 59/147 (40.14%), Postives = 86/147 (58.50%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            L  H  K ++K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ +E  ++   +E++  Y  P     EF  ++  ++  F  ++S
Sbjct:  180 LRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTP--LVAGSPIRHENAVQGSAVEVQ-TYQPPWKALSEFALQSDLDQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Match: A0A1J1IKQ7 (CLUMA_CG014062, isoform B OS=Clunio marinus OX=568069 GN=CLUMA_CG014062 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 5.419e-23
Identity = 80/256 (31.25%), Postives = 117/256 (45.70%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEV-PRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDH-----SLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELN-KNKLPGMLS--KAELMLTESPVEYE-PLELPGIEIER 989
            F   DFV+      Y H +C  CTAC + L  G ++++ E   +        +            +A   H  E S  N    V P K +  + ++R   S        E E                      ++LT H     S   + K  R RTVL+EKQLS L+  YQ+N +PDAL KEQL+E+TGL  RV+ VWFQNKRCK+KK+ +  +L  + +  G +S      ++   PV++E PL   G E+ +
Sbjct:  388 FRKNDFVMRAKTKIY-HIKCFRCTACERQLKPGDEFALREGGTLYC------KNDHDQIERMKIEEASTHHLIELSTNNRKLSVSPNKQNVCNIKNRGASSDFGSITDSESET---------------------DSLTSHHREKSSHTINGKPARVRTVLNEKQLSMLRACYQVNSRPDALVKEQLVEMTGLSPRVVRVWFQNKRCKDKKKSLEMKLQIQQEKEGKISYMNGIPLIASPPVKHESPLNYQGYEVTK 615

HSP 2 Score: 44.669 bits (104), Expect = 5.419e-23
Identity = 23/81 (28.40%), Postives = 45/81 (55.56%), Query Frame = 1 
Query:    1 YKDRLMESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRIC 243
            + + ++++ +K++  C  C   IQ Q  +++ PD+  H  CL+C +C+  L  + +CF++ G+ +C   Y  LF   C  C
Sbjct:  305 FDNNIIKTELKKSS-CVGCGREIQDQYILRVAPDLEWHAACLKCQECQQFLDENCTCFVRDGKTYCKRDYVRLFGTKCDKC 384

HSP 3 Score: 88.9669 bits (219), Expect = 3.797e-15
Identity = 51/105 (48.57%), Postives = 67/105 (63.81%), Query Frame = 3 
Query:  696 RNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKR------RISEELNKNKLP-GMLSKAELMLTESPVEYE--PLELPGIEI 983
            R RTVL+EKQL TL TF+  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK  K+      ++ +E    ++  G +    L+ T SPV  +  P+ L G E+
Sbjct:  975 RVRTVLNEKQLHTLSTFFNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKHNKKTNALKIQMEQEKEMKQIGYGRMHGVPLIAT-SPVRNDESPINLHGFEV 1078
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Match: A0A1J1IM39 (CLUMA_CG014062, isoform A OS=Clunio marinus OX=568069 GN=CLUMA_CG014062 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 5.933e-23
Identity = 80/256 (31.25%), Postives = 117/256 (45.70%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEV-PRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDH-----SLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELN-KNKLPGMLS--KAELMLTESPVEYE-PLELPGIEIER 989
            F   DFV+      Y H +C  CTAC + L  G ++++ E   +        +            +A   H  E S  N    V P K +  + ++R   S        E E                      ++LT H     S   + K  R RTVL+EKQLS L+  YQ+N +PDAL KEQL+E+TGL  RV+ VWFQNKRCK+KK+ +  +L  + +  G +S      ++   PV++E PL   G E+ +
Sbjct:  388 FRKNDFVMRAKTKIY-HIKCFRCTACERQLKPGDEFALREGGTLYC------KNDHDQIERMKIEEASTHHLIELSTNNRKLSVSPNKQNVCNIKNRGASSDFGSITDSESET---------------------DSLTSHHREKSSHTINGKPARVRTVLNEKQLSMLRACYQVNSRPDALVKEQLVEMTGLSPRVVRVWFQNKRCKDKKKSLEMKLQIQQEKEGKISYMNGIPLIASPPVKHESPLNYQGYEVTK 615

HSP 2 Score: 44.669 bits (104), Expect = 5.933e-23
Identity = 23/81 (28.40%), Postives = 45/81 (55.56%), Query Frame = 1 
Query:    1 YKDRLMESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRIC 243
            + + ++++ +K++  C  C   IQ Q  +++ PD+  H  CL+C +C+  L  + +CF++ G+ +C   Y  LF   C  C
Sbjct:  305 FDNNIIKTELKKSS-CVGCGREIQDQYILRVAPDLEWHAACLKCQECQQFLDENCTCFVRDGKTYCKRDYVRLFGTKCDKC 384

HSP 3 Score: 88.9669 bits (219), Expect = 3.965e-15
Identity = 51/105 (48.57%), Postives = 67/105 (63.81%), Query Frame = 3 
Query:  696 RNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKR------RISEELNKNKLP-GMLSKAELMLTESPVEYE--PLELPGIEI 983
            R RTVL+EKQL TL TF+  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK  K+      ++ +E    ++  G +    L+ T SPV  +  P+ L G E+
Sbjct:  975 RVRTVLNEKQLHTLSTFFNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKHNKKTNALKIQMEQEKEMKQIGYGRMHGVPLIAT-SPVRNDESPINLHGFEV 1078
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Match: A0A210QBY0 (Insulin gene enhancer protein isl-1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT15457 PE=4 SV=1)

HSP 1 Score: 103.99 bits (258), Expect = 8.261e-21
Identity = 78/255 (30.59%), Postives = 125/255 (49.02%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVIC-TDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEVPRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI--------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIE 986
            F  +DFV+    + Y H  C  C AC + L  G ++++ +  + C  D ++ ++                + S EN  E+    +   N+  ++R          ++  ++  ++   +   +   +    + +N    H  K+ +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL E+T L  RVI VWFQNKRCK+KKR I         +E N  +L G L     M+  SPV +E P++   +E++
Sbjct:   89 FGKSDFVMRAKNNVY-HIDCFRCVACSRQLIPGDEFALRDDGLFCKADHEVVER----------------ASSKENGSEDGSPRINNNNNIVTKR---------ANKNNDDNNNNEKGLSLVAGRAEQVSNTKTNGTRSHVHKSEQKPTRIRTVLNEKQLHTLRTCYNANPRPDALMKEQLTEMTNLSPRVIRVWFQNKRCKDKKRSILMKQLQHQQQEKNGGRLHGPLQGVP-MVASSPVRHESPMQANAVEVQ 316
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Match: A0A2L2YMM7 (Uncharacterized protein (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 8.632e-21
Identity = 79/255 (30.98%), Postives = 118/255 (46.27%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVIC---TDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEVPRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIE 986
            F  +DFV+  +R+   H +C  C  C + L  G ++++ +  + C    DC + K++T           A   HS  N   N        N+ S + +R+ +S                                      H   +  K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I       +E +  +L     +   M+  SPV +E P+++  IE++
Sbjct:   41 FSRSDFVM-RARNKIYHIECFRCVTCTRQLLPGDEFALRDDGLFCKADNDCTVEKKITPNGHT------ANGQHSPHNGTTNGTSLQMAANAESMQSNRNRDSVRPQV---------------------------------HKQSSDHKPTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKTIMMKQLQQQEKDGRQLTLGSMRGVPMVATSPVRHESPIQMNPIEVQ 255
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Match: A0A1B6MUS9 (Homeobox domain-containing protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.50997 PE=4 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 9.519e-21
Identity = 55/107 (51.40%), Postives = 73/107 (68.22%), Query Frame = 3 
Query:  672 LKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRIS--EELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEI 983
            + +  K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I+  ++L + K+     +   M+  SPV +E PL +  IE+
Sbjct:   31 VSSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRAIAMKQQLQQEKMGYGSMQGIPMVASSPVRHESPLGMNPIEV 137
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Match: isl2a (ISL LIM homeobox 2 [Source:NCBI gene;Acc:103023279])

HSP 1 Score: 98.2117 bits (243), Expect = 2.085e-22
Identity = 60/145 (41.38%), Postives = 86/145 (59.31%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I        +  +K  L G+      ++  SP+ ++  ++   +E++  Y  P     EF  ++  E+  F  ++S
Sbjct:  182 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQLQQQQHSDKTNLQGLTGTP--LVAGSPIRHDNTVQGNPVEVQ-TYQPPWKALSEFALQSDLEQPAFQQLVS 323
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Match: isl2b (ISL LIM homeobox 2b [Source:NCBI gene;Acc:30151])

HSP 1 Score: 96.2857 bits (238), Expect = 8.008e-22
Identity = 47/69 (68.12%), Postives = 55/69 (79.71%), Query Frame = 3 
Query:  666 HSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            H+ K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I
Sbjct:  174 HAPKPSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSI 242

HSP 2 Score: 41.9726 bits (97), Expect = 1.422e-7
Identity = 21/67 (31.34%), Postives = 34/67 (50.75%), Query Frame = 1 
Query:   43 ICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRIC 243
            +C  C   I  Q  +++ PD+  H  CL+C +C   L  + +CF++ G+ +C   Y  LF   C  C
Sbjct:   26 MCVGCGIQIHDQYILRVSPDLEWHAACLKCAECSQYLDENCTCFVREGKTYCKRDYVRLFGVKCAKC 92

HSP 3 Score: 33.113 bits (74), Expect = 1.422e-7
Identity = 15/45 (33.33%), Postives = 27/45 (60.00%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVIC 386
            F N+D V+  +R    H +C  C+AC + L  G ++S+ E +++C
Sbjct:   96 FTNSDLVMR-ARDSVYHIKCFRCSACGRQLLPGEEFSVREDALLC 139
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Match: ENSAMXT00000031017.1 (insulin gene enhancer protein ISL-1-like [Source:NCBI gene;Acc:103021841])

HSP 1 Score: 93.9745 bits (232), Expect = 4.332e-21
Identity = 53/126 (42.06%), Postives = 71/126 (56.35%), Query Frame = 3 
Query:  675 KTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESP------VEYEPLELPGIEIERVYNNPGEFHKENSYE 1034
            K+  +  R RTVLSE QL TLQ+ Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR  +    +N+    +++     T SP      V   PL+L   +          F  ++ Y+
Sbjct:  172 KSKSRMTRVRTVLSEAQLHTLQSCYSANPRPDALLKEQLVELTGLSPRVIRVWFQNKRCKDKKRSTAARNTQNRPNQQVNQHVNFFTASPDSLDQEVLMTPLDLQNFQPSWKLLTSFSFQSDSDYD 297
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Match: ENSAMXT00000019414.2 (insulin gene enhancer protein ISL-1-like [Source:NCBI gene;Acc:103021841])

HSP 1 Score: 92.8189 bits (229), Expect = 1.038e-20
Identity = 55/133 (41.35%), Postives = 74/133 (55.64%), Query Frame = 3 
Query:  681 SKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESP------VEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLS 1061
            +++  R RTVLSE QL TLQ+ Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR  +    +N+    +++ E   T SP      V   PL+L   +          F  ++ Y+      M S
Sbjct:  165 AERMTRVRTVLSEAQLHTLQSCYSANPRPDALLKEQLVELTGLSPRVIRVWFQNKRCKDKKRSTAARNTQNRPNQQVNQHEF-FTASPDSLDQEVLMTPLDLQNFQPSWKLLTSFSFQSDSDYDSTQHQQMTS 296
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Match: isl1 (ISL LIM homeobox 1 [Source:NCBI gene;Acc:103024036])

HSP 1 Score: 92.8189 bits (229), Expect = 1.079e-20
Identity = 59/147 (40.14%), Postives = 84/147 (57.14%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEEL-------NKNKLPGMLSKAELMLTESPVEYE-PLELPGIEIERVYNNP----GEFHKENSYEEKYFTAMLS 1061
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR +  +        +K  + GM      M+  SP  ++  L+   +E++  Y  P     +F  ++  ++  F  ++S
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSLLMKQLQQQQPNDKTNIQGMTGTP--MVAASPERHDGGLQASQVEVQ-TYQPPWKVLSDFALQSDIDQPAFQQLVS 313
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002189.1 (pep scaffold:Pmarinus_7.0:GL483992:1961:4872:1 gene:ENSPMAG00000001979.1 transcript:ENSPMAT00000002189.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 98.2117 bits (243), Expect = 1.354e-23
Identity = 55/108 (50.93%), Postives = 69/108 (63.89%), Query Frame = 3 
Query:  684 KKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIE 986
            +KA R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR I           +K  L G+      ++  SPV +E   +PG  +E
Sbjct:  115 EKATRVRTVLNEKQLQTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQMQQQHHADKTNLQGLTGTP--LVAGSPVPHE-AAIPGNPVE 219
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009847.1 (pep scaffold:Pmarinus_7.0:GL481168:3356:14379:1 gene:ENSPMAG00000008904.1 transcript:ENSPMAT00000009847.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.3882 bits (150), Expect = 2.196e-11
Identity = 27/54 (50.00%), Postives = 35/54 (64.81%), Query Frame = 3 
Query:  702 RTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            RT +  KQL TL+  +   PKP    +EQL + TGL  RVI VWFQN+R KE++
Sbjct:   31 RTTIKAKQLETLRAAFAATPKPSRHVREQLAQETGLNMRVIQVWFQNRRSKERR 84
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000489.1 (pep scaffold:Pmarinus_7.0:GL476379:43572:49059:-1 gene:ENSPMAG00000000440.1 transcript:ENSPMAT00000000489.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.9062 bits (115), Expect = 2.118e-6
Identity = 25/73 (34.25%), Postives = 41/73 (56.16%), Query Frame = 3 
Query:  654 NLTDHSLKTSKKAPRN---RTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            + + +SL  S+  PR+   RT ++ +QL  L   Y ++  P     + +    GLK+RV+ VWFQN R +E+K
Sbjct:  579 DASTNSLNNSEDQPRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERK 651
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009434.1 (pep scaffold:Pmarinus_7.0:GL476605:204971:209125:-1 gene:ENSPMAG00000008536.1 transcript:ENSPMAT00000009434.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.1358 bits (113), Expect = 3.465e-6
Identity = 30/93 (32.26%), Postives = 49/93 (52.69%), Query Frame = 3 
Query:  696 RNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESP-----VEYEP 959
            R RT ++E+QL+ L+ ++ +N  P     +++ + +GL Q+VI  WF+N   KE++R      N N  P   S  E+ L   P     V+ EP
Sbjct:  695 RPRTRITEEQLNILRAYFDINNSPGDEQIQEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFNNPPSS-SHDEIKLDSQPPTPESVQSEP 786
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Match: dmbx1b (diencephalon/mesencephalon homeobox 1b [Source:NCBI gene;Acc:550288])

HSP 1 Score: 46.2098 bits (108), Expect = 7.568e-6
Identity = 21/60 (35.00%), Postives = 36/60 (60.00%), Query Frame = 3 
Query:  696 RNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRIS 875
            R+RT  + +QL  L+  +Q    PD + +E+L   T L +  + VWF+N+R K +K++ S
Sbjct:   45 RSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRS 104
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Match: EDO46073 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR95])

HSP 1 Score: 87.4261 bits (215), Expect = 3.567e-19
Identity = 41/66 (62.12%), Postives = 52/66 (78.79%), Query Frame = 3 
Query:  669 SLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKR 866
            S + + +  R RTVL+EKQL TL+T Y  NP+PDA+ KEQL+E+TGL  RVI VWFQNKRCK+KK+
Sbjct:  173 SKRKTDRPTRVRTVLNEKQLHTLRTCYNANPRPDAMMKEQLVEMTGLSPRVIRVWFQNKRCKDKKK 238
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Match: LHX1 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9E9])

HSP 1 Score: 59.6918 bits (143), Expect = 2.178e-10
Identity = 28/67 (41.79%), Postives = 42/67 (62.69%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            D +L + ++ PR  T +  KQL  L++ +   PKP    +E+L + TGL  RVI VWFQN+R KE++
Sbjct:  146 DAALASKRRGPR--TTIKAKQLEALKSTFAATPKPSRNIREKLAQETGLNMRVIQVWFQNRRSKERR 210
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Match: EDO34370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPK5])

HSP 1 Score: 60.4622 bits (145), Expect = 3.198e-10
Identity = 29/67 (43.28%), Postives = 43/67 (64.18%), Query Frame = 3 
Query:  666 HSLKTSK-KAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            +SLK+ + KA R RT  +E QL  LQ  + ++  PD    E++ ++TGL +RV  VWFQN R ++KK
Sbjct:  171 NSLKSGRHKAKRVRTTFTEDQLQILQANFNIDSNPDGQDLERIAQLTGLSKRVTQVWFQNSRARQKK 237
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Match: EDO40916 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5Q7])

HSP 1 Score: 54.299 bits (129), Expect = 6.280e-10
Identity = 23/59 (38.98%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:  687 KAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            KAPRNR   +  QL  L+  ++    PDA+T+E L +  GL +  + +WFQN+R K ++
Sbjct:    1 KAPRNRKNFTGDQLRDLERLFEQTHYPDAMTREGLAKKLGLSEARVQIWFQNRRAKSRR 59
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Match: GSC (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S024])

HSP 1 Score: 55.4546 bits (132), Expect = 4.862e-9
Identity = 31/86 (36.05%), Postives = 51/86 (59.30%), Query Frame = 3 
Query:  684 KKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCK-EKKRRISEELNKNKLPGMLSKAELMLTE 938
            K+  R+RT+ +E+QL  L+T +Q    PD L +E+L     LK+  + VWF+N+R K  K++R + +  K     +L +A+  LTE
Sbjct:   72 KRKRRHRTIFTEEQLELLETTFQKTHYPDVLLREELAMKVDLKEERVEVWFKNRRAKWRKQKREAVDSKKANEEDLLQQADSPLTE 157
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Match: ISL2 (insulin gene enhancer protein isl-2a [Source:NCBI gene;Acc:101169602])

HSP 1 Score: 94.7449 bits (234), Expect = 2.636e-21
Identity = 51/105 (48.57%), Postives = 68/105 (64.76%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE 956
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ ++
Sbjct:  181 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQIQQQQHNDKTNLQGLTGTP--LVAGSPIRHD 283
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Match: ISL2 (insulin gene enhancer protein isl-2a [Source:NCBI gene;Acc:101169602])

HSP 1 Score: 94.7449 bits (234), Expect = 3.192e-21
Identity = 51/105 (48.57%), Postives = 68/105 (64.76%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-------SEELNKNKLPGMLSKAELMLTESPVEYE 956
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I        +  +K  L G+      ++  SP+ ++
Sbjct:  181 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQIQQQQHNDKTNLQGLTGTP--LVAGSPIRHD 283
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Match: ISL2 (insulin gene enhancer protein ISL-3 [Source:NCBI gene;Acc:101174255])

HSP 1 Score: 94.3597 bits (233), Expect = 5.844e-21
Identity = 46/70 (65.71%), Postives = 55/70 (78.57%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI 872
            +H  K S+K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KK+ I
Sbjct:  183 NHVHKQSEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSI 252
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Match: isl1 (ISL LIM homeobox 1 [Source:NCBI gene;Acc:101165983])

HSP 1 Score: 92.8189 bits (229), Expect = 1.498e-20
Identity = 46/70 (65.71%), Postives = 53/70 (75.71%), Query Frame = 3 
Query:  657 LTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKR 866
            L  H  K  +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR
Sbjct:  170 LRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKR 239
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Match: lhx4 (LIM homeobox 4 [Source:NCBI gene;Acc:101165225])

HSP 1 Score: 63.929 bits (154), Expect = 9.514e-11
Identity = 29/56 (51.79%), Postives = 39/56 (69.64%), Query Frame = 3 
Query:  696 RNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKK 863
            R RT ++ KQL TL++ Y+ +PKP    +EQL   TGL  RV+ VWFQN+R KEK+
Sbjct:  160 RPRTTITAKQLETLKSAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 215
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Match: SMESG000029651.1 (SMESG000029651.1)

HSP 1 Score: 509.22 bits (1310), Expect = 0.000e+0
Identity = 303/303 (100.00%), Postives = 303/303 (100.00%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEVPRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH 1160
            FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQLTSFSELSTTSFQAGNSHSSENSIENPDFEVPRKNSASSERDRSMESGGDDDEKEEEEISDNGSIDSDSDDFDLSMRSSSNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH
Sbjct:   80 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQLTSFSELSTTSFQAGNSHSSENSIENPDFEVPRKNSASSERDRSMESGGDDDEKEEEEISDNGSIDSDSDDFDLSMRSSSNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH 382

HSP 2 Score: 171.014 bits (432), Expect = 0.000e+0
Identity = 79/80 (98.75%), Postives = 79/80 (98.75%), Query Frame = 1 
Query:   16 MESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSL 255
            MESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGS 
Sbjct:    1 MESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSF 80
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Match: SMESG000029651.1 (SMESG000029651.1)

HSP 1 Score: 508.834 bits (1309), Expect = 0.000e+0
Identity = 303/303 (100.00%), Postives = 303/303 (100.00%), Query Frame = 3 
Query:  252 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQXXXXXXXXXXXXQAGNSHSSENSIENPDFEVPRKNSASSERDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH 1160
            FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQLTSFSELSTTSFQAGNSHSSENSIENPDFEVPRKNSASSERDRSMESGGDDDEKEEEEISDNGSIDSDSDDFDLSMRSSSNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH
Sbjct:   96 FVNTDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVICTDCQISKQLTSFSELSTTSFQAGNSHSSENSIENPDFEVPRKNSASSERDRSMESGGDDDEKEEEEISDNGSIDSDSDDFDLSMRSSSNNLTDHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERVYNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYSSPLRLH 398

HSP 2 Score: 181.415 bits (459), Expect = 0.000e+0
Identity = 84/85 (98.82%), Postives = 84/85 (98.82%), Query Frame = 1 
Query:    1 YKDRLMESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSL 255
            YKDRLMESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGS 
Sbjct:   12 YKDRLMESVIKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSF 96
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Match: SMESG000059633.1 (SMESG000059633.1)

HSP 1 Score: 96.6709 bits (239), Expect = 1.550e-21
Identity = 50/96 (52.08%), Postives = 69/96 (71.88%), Query Frame = 3 
Query:  684 KKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRI-SEELNKNKLPGMLS---KAELMLTESPVEYEP 959
            +K  R RTVL+EKQL TL+T Y  NP+PDAL KEQL+E+TGL  RVI VWFQNKRCK+KKR+I  +++++++  G +    +   M+  SP+  EP
Sbjct:  304 QKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRQIMVKQMDQHQQVGGIDCPLQGVPMVAGSPMRNEP 399

HSP 2 Score: 61.2326 bits (147), Expect = 8.794e-13
Identity = 27/76 (35.53%), Postives = 43/76 (56.58%), Query Frame = 1 
Query:   28 IKENPICRVCNGFIQGQLSVKIEPDIPVHENCLRCYQCRTSLVYDDSCFIKFGRIFCHSHYRALFLKICRICYGSL 255
            IK   +C  C G I  +  ++++PD+  H  CLRC +C   L   ++CF+K G+ +C   Y+ LFL++C  C   L
Sbjct:   22 IKSCSLCVGCGGAITDKFILRVQPDLEWHARCLRCVKCNRGLDEKNTCFVKDGKTYCKEDYQKLFLQVCAACNRGL 97

HSP 3 Score: 30.8018 bits (68), Expect = 8.794e-13
Identity = 14/42 (33.33%), Postives = 23/42 (54.76%), Query Frame = 3 
Query:  261 TDFVLPFSRHDYCHAQCLNCTACRKPLTSGCKYSICEFSVIC 386
            +D+VL      Y H  C+ C AC + L +G ++++    VIC
Sbjct:  100 SDYVLHVGSRIY-HISCMKCVACNRVLQTGDEFAMRPNGVIC 140
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BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Match: SMESG000022856.1 (SMESG000022856.1)

HSP 1 Score: 62.3882 bits (150), Expect = 1.467e-10
Identity = 29/73 (39.73%), Postives = 45/73 (61.64%), Query Frame = 3 
Query:  663 DHSLKTSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRRISEE 881
            D S +  ++ PR  T +   QL +L+  + + PKP    +E+L E TGL  RVI VWFQN+R KE++ ++S +
Sbjct:  200 DKSCEIRRRTPR--TTIKASQLDSLKATFSITPKPSRQMREKLAECTGLSMRVIQVWFQNRRSKERRSKLSSQ 270
[Close]
BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Match: SMESG000043039.1 (SMESG000043039.1)

HSP 1 Score: 62.003 bits (149), Expect = 3.989e-10
Identity = 29/64 (45.31%), Postives = 40/64 (62.50%), Query Frame = 3 
Query:  678 TSKKAPRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQNKRCKEKKRR 869
            T ++ PR  T +  KQL TL+  +   PKP    +EQL + TGL  RVI VWFQN+R KE++ +
Sbjct:  399 TKRRGPR--TTIKAKQLDTLKAAFSATPKPTRHVREQLAQDTGLTMRVIQVWFQNRRSKERRMK 460
The following BLAST results are available for this feature:
BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ISL24.344e-2240.14ISL LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18... [more]
ISL18.699e-2165.28ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:61... [more]
ISL11.020e-2065.28ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:61... [more]
LHX39.310e-1151.72LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595][more]
LHX39.572e-1151.72LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595][more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lim-71.503e-1733.53CeLIM-7; LIM domain family [Source:UniProtKB/TrEM... [more]
lim-41.687e-1045.76LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0... [more]
lim-41.688e-1045.76LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0... [more]
lim-41.768e-1045.76LIM domain family [Source:UniProtKB/TrEMBL;Acc:A0... [more]
ceh-452.526e-1039.71C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tup1.058e-2148.18gene:FBgn0003896 transcript:FBtr0081112[more]
tup1.733e-2147.41gene:FBgn0003896 transcript:FBtr0081111[more]
tup1.733e-2147.41gene:FBgn0003896 transcript:FBtr0342921[more]
Lim33.844e-1249.25gene:FBgn0002023 transcript:FBtr0309834[more]
Lim34.223e-1249.25gene:FBgn0002023 transcript:FBtr0081169[more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
isl2b1.866e-2543.75ISL LIM homeobox 2b [Source:NCBI gene;Acc:30151][more]
isl1l1.147e-2345.74islet1, like [Source:ZFIN;Acc:ZDB-GENE-040624-1][more]
isl1l2.748e-2344.62islet1, like [Source:ZFIN;Acc:ZDB-GENE-040624-1][more]
isl2a2.175e-2140.69ISL LIM homeobox 2a [Source:NCBI gene;Acc:30157][more]
isl17.789e-2165.28ISL LIM homeobox 1 [Source:NCBI gene;Acc:30147][more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
isl26.580e-2238.93ISL LIM homeobox 2 [Source:NCBI gene;Acc:100306962... [more]
isl28.314e-2238.93ISL LIM homeobox 2 [Source:NCBI gene;Acc:100306962... [more]
ISL11.028e-2065.28ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:61... [more]
ISL11.175e-2065.28ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:61... [more]
gfm29.918e-1131.82G elongation factor, mitochondrial 2 [Source:Xenba... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Isl22.555e-2239.86insulin related protein 2 (islet 2) [Source:MGI Sy... [more]
Isl15.972e-2165.28ISL1 transcription factor, LIM/homeodomain [Source... [more]
Isl17.003e-2165.28ISL1 transcription factor, LIM/homeodomain [Source... [more]
Lhx13.776e-1142.47LIM homeobox protein 1 [Source:MGI Symbol;Acc:MGI:... [more]
Lhx43.968e-1151.72LIM homeobox protein 4 [Source:MGI Symbol;Acc:MGI:... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P53407|ISL2B_DANRE1.408e-2443.75Insulin gene enhancer protein isl-2b OS=Danio reri... [more]
sp|P50212|ISL2B_ONCTS1.911e-2241.67Insulin gene enhancer protein ISL-2B (Fragment) OS... [more]
sp|P50480|ISL2_RAT7.720e-2240.54Insulin gene enhancer protein ISL-2 OS=Rattus norv... [more]
sp|Q9CXV0|ISL2_MOUSE1.787e-2139.86Insulin gene enhancer protein ISL-2 OS=Mus musculu... [more]
sp|Q96A47|ISL2_HUMAN2.086e-2140.14Insulin gene enhancer protein ISL-2 OS=Homo sapien... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1J1IKQ75.419e-2331.25CLUMA_CG014062, isoform B OS=Clunio marinus OX=568... [more]
A0A1J1IM395.933e-2331.25CLUMA_CG014062, isoform A OS=Clunio marinus OX=568... [more]
A0A210QBY08.261e-2130.59Insulin gene enhancer protein isl-1 OS=Mizuhopecte... [more]
A0A2L2YMM78.632e-2130.98Uncharacterized protein (Fragment) OS=Parasteatoda... [more]
A0A1B6MUS99.519e-2151.40Homeobox domain-containing protein (Fragment) OS=G... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
isl2a2.085e-2241.38ISL LIM homeobox 2 [Source:NCBI gene;Acc:103023279... [more]
isl2b8.008e-2268.12ISL LIM homeobox 2b [Source:NCBI gene;Acc:30151][more]
ENSAMXT00000031017.14.332e-2142.06insulin gene enhancer protein ISL-1-like [Source:N... [more]
ENSAMXT00000019414.21.038e-2041.35insulin gene enhancer protein ISL-1-like [Source:N... [more]
isl11.079e-2040.14ISL LIM homeobox 1 [Source:NCBI gene;Acc:103024036... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000002189.11.354e-2350.93pep scaffold:Pmarinus_7.0:GL483992:1961:4872:1 gen... [more]
ENSPMAT00000009847.12.196e-1150.00pep scaffold:Pmarinus_7.0:GL481168:3356:14379:1 ge... [more]
ENSPMAT00000000489.12.118e-634.25pep scaffold:Pmarinus_7.0:GL476379:43572:49059:-1 ... [more]
ENSPMAT00000009434.13.465e-632.26pep scaffold:Pmarinus_7.0:GL476605:204971:209125:-... [more]
dmbx1b7.568e-635.00diencephalon/mesencephalon homeobox 1b [Source:NCB... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO460733.567e-1962.12Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
LHX12.178e-1041.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO343703.198e-1043.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO409166.280e-1038.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
GSC4.862e-936.05Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ISL22.636e-2148.57insulin gene enhancer protein isl-2a [Source:NCBI ... [more]
ISL23.192e-2148.57insulin gene enhancer protein isl-2a [Source:NCBI ... [more]
ISL25.844e-2165.71insulin gene enhancer protein ISL-3 [Source:NCBI g... [more]
isl11.498e-2065.71ISL LIM homeobox 1 [Source:NCBI gene;Acc:101165983... [more]
lhx49.514e-1151.79LIM homeobox 4 [Source:NCBI gene;Acc:101165225][more]
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BLAST of Insulin gene enhancer protein isl-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000029651.10.000e+0100.00SMESG000029651.1[more]
SMESG000029651.10.000e+0100.00SMESG000029651.1[more]
SMESG000059633.11.550e-2152.08SMESG000059633.1[more]
SMESG000022856.11.467e-1039.73SMESG000022856.1[more]
SMESG000043039.13.989e-1045.31SMESG000043039.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013688 ID=SMED30013688|Name=Insulin gene enhancer protein isl-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1229bp
TATAAAGATCGATTAATGGAATCAGTGATTAAAGAAAATCCGATTTGCAG
AGTTTGCAATGGTTTTATCCAAGGCCAATTGAGCGTGAAAATCGAGCCAG
ATATTCCAGTTCATGAAAATTGTCTCAGATGTTACCAATGCAGAACATCA
CTAGTCTATGACGATTCATGCTTCATTAAATTCGGGAGGATATTCTGTCA
CAGCCATTACCGAGCATTGTTTCTGAAAATCTGCCGTATCTGCTATGGGA
GTTTGTGAACACGGATTTCGTGTTGCCTTTCTCCCGGCACGATTACTGTC
ACGCGCAATGTCTGAATTGCACCGCTTGTAGAAAGCCACTGACGTCCGGG
TGCAAATATTCCATTTGTGAGTTCTCGGTTATTTGTACTGATTGCCAGAT
TTCCAAACAACTCACAAGCTTTTCTGAACTTTCAACTACCAGTTTTCAGG
CTGGAAATTCACATTCTTCCGAAAACAGTATTGAAAATCCCGATTTTGAA
GTGCCAAGGAAAAACTCGGCATCGTCAGAAAGAGATAGGTCTATGGAAAG
TGGTGGCGATGATGATGAGAAGGAGGAGGAGGAAATCAGTGATAACGGAA
GTATCGACAGCGATTCGGATGACTTCGACCTATCTATGAGATCGAGTTCT
AATAATCTGACTGATCATTCACTCAAGACCAGCAAAAAAGCGCCTAGGAA
TAGAACAGTTCTATCAGAAAAACAGTTAAGCACCCTTCAGACATTTTATC
AAATGAACCCAAAGCCAGACGCATTGACCAAAGAACAATTAATGGAAGTC
ACTGGACTCAAACAACGAGTAATAAGTGTTTGGTTTCAGAATAAAAGATG
TAAAGAGAAAAAAAGGCGAATTTCTGAAGAACTAAATAAAAATAAACTGC
CAGGCATGTTATCAAAGGCAGAATTGATGCTCACGGAGAGTCCAGTTGAA
TATGAGCCGCTGGAGTTGCCGGGAATCGAAATAGAAAGAGTATATAATAA
TCCCGGTGAATTCCACAAAGAGAACTCATATGAGGAAAAGTATTTCACAG
CAATGTTATCTAACACAAGACCAGATCTCTCATTACGTAGCCGGTGCCAT
TTGCCCTTGGTCCACGCCGTCAACAATCAGAATAAATACTCAAGTCCTCT
CAGGCTTCATTAATTGCAAAAAGATATCAATTATTAAATATTATTGTTTT
AAGTTTTGCTTATTTAACTGCTCATTTCA
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protein sequence of SMED30013688-orf-1

>SMED30013688-orf-1 ID=SMED30013688-orf-1|Name=SMED30013688-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=207bp
MESGGDDDEKEEEEISDNGSIDSDSDDFDLSMRSSSNNLTDHSLKTSKKA
PRNRTVLSEKQLSTLQTFYQMNPKPDALTKEQLMEVTGLKQRVISVWFQN
KRCKEKKRRISEELNKNKLPGMLSKAELMLTESPVEYEPLELPGIEIERV
YNNPGEFHKENSYEEKYFTAMLSNTRPDLSLRSRCHLPLVHAVNNQNKYS
SPLRLH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR001356Homeobox_dom
IPR009057Homeobox-like_sf
IPR001781Znf_LIM
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0008270zinc ion binding
GO:0043565sequence-specific DNA binding
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
GO:0007275multicellular organism development
GO:0031017exocrine pancreas development
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001781Zinc finger, LIM-typeSMARTSM00132lim_4coord: 15..69
e-value: 1.0E-4
score: 31.7
IPR001781Zinc finger, LIM-typePFAMPF00412LIMcoord: 16..72
e-value: 1.1E-7
score: 31.9
IPR001781Zinc finger, LIM-typePROSITEPS50023LIM_DOMAIN_2coord: 14..76
score: 10.771
NoneNo IPR availableGENE3DG3DSA:2.10.110.10coord: 2..86
e-value: 1.2E-12
score: 49.7
NoneNo IPR availablePANTHERPTHR24204FAMILY NOT NAMEDcoord: 11..85
NoneNo IPR availablePANTHERPTHR24204:SF8TAILUP, ISOFORM Acoord: 11..85