Density-regulated protein

Overview
NameDensity-regulated protein
Smed IDSMED30013663
Length (bp)634
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Density-regulated protein (SMED30013663) t-SNE clustered cells

Violin plots show distribution of expression levels for Density-regulated protein (SMED30013663) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Density-regulated protein (SMED30013663) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Density-regulated protein (SMED30013663) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013663

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30013663SMESG000077900.1 SmedASXL_019606SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Density-regulated protein vs. Ensembl Human
Match: DENR (density regulated re-initiation and release factor [Source:HGNC Symbol;Acc:HGNC:2769])

HSP 1 Score: 181.415 bits (459), Expect = 2.203e-57
Identity = 91/174 (52.30%), Postives = 121/174 (69.54%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESGDDQKH----------RQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G  +            +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. Ensembl Human
Match: DENR (density regulated re-initiation and release factor [Source:HGNC Symbol;Acc:HGNC:2769])

HSP 1 Score: 124.02 bits (310), Expect = 2.040e-35
Identity = 64/133 (48.12%), Postives = 86/133 (64.66%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESGDDQKH----------RQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSS 466
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G  +            +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+S
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGAS 157
[Close]
BLAST of Density-regulated protein vs. Ensembl Celegans
Match: Y47D3A.21 (Density-regulated protein homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9NAH4])

HSP 1 Score: 162.54 bits (410), Expect = 1.425e-50
Identity = 87/182 (47.80%), Postives = 114/182 (62.64%), Query Frame = 2 
Query:   86 VYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQTRGGK--------------GQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            +  GP++GV YPL + YCG+C +P EYC++    + C+ W  +N PE  E L I D+ + D  + ++ + G                  KKK     K+ + R  RG KK VTVI GL T+ IDLKVASK+F QKFA GSSVTGADEIVIQGD+KDDL+D I EKW ++ +E I+DLGD KR
Sbjct:   12 LAPGPIDGVSYPLKMVYCGQCSMPPEYCDYSGQTDVCRAWATQNAPELLEGLEISDEPAADGDEKKKQKRGGKGSKTGAAAAQAAASGGKKKGGGPQKVTLQREPRG-KKSVTVIKGLATFDIDLKVASKLFAQKFACGSSVTGADEIVIQGDVKDDLLDLIPEKWKQVTDEQIDDLGDKKR 192
[Close]
BLAST of Density-regulated protein vs. Ensembl Fly
Match: DENR (gene:FBgn0030802 transcript:FBtr0310520)

HSP 1 Score: 189.889 bits (481), Expect = 3.146e-61
Identity = 104/171 (60.82%), Postives = 130/171 (76.02%), Query Frame = 2 
Query:   95 GPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSI----IDKESGDDQKHRQTRGGKG--QIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            GP EGV YP+ +KYCG C +P EYCE+    EKCK+WLE ++P+++E+L I       +  DD K RQ RGGKG  ++KKK++V  +I +SRA+RG+KK VTV+TGL+T+ IDLKVA+K FG KFA GSSVTG DEIVIQGD+KDDL D I EKW EIDE+ IEDLGD KR
Sbjct:   18 GPREGVTYPIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRVKKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWAEIDEDVIEDLGDQKR 188
[Close]
BLAST of Density-regulated protein vs. Ensembl Fly
Match: DENR (gene:FBgn0030802 transcript:FBtr0074347)

HSP 1 Score: 189.889 bits (481), Expect = 3.146e-61
Identity = 104/171 (60.82%), Postives = 130/171 (76.02%), Query Frame = 2 
Query:   95 GPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSI----IDKESGDDQKHRQTRGGKG--QIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            GP EGV YP+ +KYCG C +P EYCE+    EKCK+WLE ++P+++E+L I       +  DD K RQ RGGKG  ++KKK++V  +I +SRA+RG+KK VTV+TGL+T+ IDLKVA+K FG KFA GSSVTG DEIVIQGD+KDDL D I EKW EIDE+ IEDLGD KR
Sbjct:   18 GPREGVTYPIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRVKKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWAEIDEDVIEDLGDQKR 188
[Close]
BLAST of Density-regulated protein vs. Ensembl Zebrafish
Match: denr (density-regulated protein [Source:NCBI gene;Acc:436970])

HSP 1 Score: 162.54 bits (410), Expect = 5.210e-50
Identity = 82/184 (44.57%), Postives = 110/184 (59.78%), Query Frame = 2 
Query:  116 YPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQT-------------------------RGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            YPL V YCG C LP EYCE+     KCKQWLEKN P+ + KL++      + +                              RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ I+LK A + F QKF+ G+SVT  DEI+IQGD  DD+ID I EKWPE+D+++I+DLG+ K+
Sbjct:   25 YPLKVLYCGVCSLPAEYCEYMPEPAKCKQWLEKNFPDVFAKLTLGTAPKQESKGGGGGEDGGGGRGRGEAPPAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIELKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK 208
[Close]
BLAST of Density-regulated protein vs. Ensembl Zebrafish
Match: denr (density-regulated protein [Source:NCBI gene;Acc:436970])

HSP 1 Score: 162.54 bits (410), Expect = 5.210e-50
Identity = 82/184 (44.57%), Postives = 110/184 (59.78%), Query Frame = 2 
Query:  116 YPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQT-------------------------RGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            YPL V YCG C LP EYCE+     KCKQWLEKN P+ + KL++      + +                              RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ I+LK A + F QKF+ G+SVT  DEI+IQGD  DD+ID I EKWPE+D+++I+DLG+ K+
Sbjct:   25 YPLKVLYCGVCSLPAEYCEYMPEPAKCKQWLEKNFPDVFAKLTLGTAPKQESKGGGGGEDGGGGRGRGEAPPAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIELKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK 208
[Close]
BLAST of Density-regulated protein vs. Ensembl Xenopus
Match: denr (density-regulated protein [Source:NCBI gene;Acc:448530])

HSP 1 Score: 176.792 bits (447), Expect = 1.467e-55
Identity = 88/173 (50.87%), Postives = 119/173 (68.79%), Query Frame = 2 
Query:  113 DYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSI---IDKESGDDQKHRQT----------RGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            D PL V YCG C LPTEYCE+  +V KC+QWLEKN P+E+ KL++     +E+G  +    +          RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ I+LK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   28 DLPLKVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPDEFSKLTLGISPKQETGTVEGQATSGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIELKDAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 200
[Close]
BLAST of Density-regulated protein vs. Ensembl Xenopus
Match: denr (density-regulated protein [Source:NCBI gene;Acc:448530])

HSP 1 Score: 154.066 bits (388), Expect = 1.169e-46
Identity = 84/172 (48.84%), Postives = 115/172 (66.86%), Query Frame = 2 
Query:  113 DYPLNVKYCG-EC-ELPTEYCEFGANVEKCKQWLEKNLPEEYEKLS--IIDKESGDDQKHRQTRGG--------KGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            D PL V YCG +C  L + YCE+  +V KC+QWLEKN P+E+ KL+  I  K+     + + T G         +GQIK KKK V  K+ I++  R +KK+VT + GL T+ I+LK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   28 DLPLKVLYCGGKCILLYSTYCEYMPDVAKCRQWLEKNFPDEFSKLTLGISPKQETGTVEGQATSGEEEEKKKQKRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIELKDAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 199
[Close]
BLAST of Density-regulated protein vs. Ensembl Mouse
Match: Denr (density-regulated protein [Source:MGI Symbol;Acc:MGI:1915434])

HSP 1 Score: 181.03 bits (458), Expect = 2.338e-57
Identity = 92/174 (52.87%), Postives = 124/174 (71.26%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESG----------DDQKHRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G          +++K +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. Ensembl Mouse
Match: Denr (density-regulated protein [Source:MGI Symbol;Acc:MGI:1915434])

HSP 1 Score: 159.844 bits (403), Expect = 2.743e-49
Identity = 82/158 (51.90%), Postives = 106/158 (67.09%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESGDDQKH----------RQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKW 541
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G  +            +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKW
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKW 182
[Close]
BLAST of Density-regulated protein vs. UniProt/SwissProt
Match: sp|Q9VX98|DENR_DROME (Density-regulated protein homolog OS=Drosophila melanogaster OX=7227 GN=DENR PE=1 SV=3)

HSP 1 Score: 189.889 bits (481), Expect = 3.154e-60
Identity = 104/171 (60.82%), Postives = 130/171 (76.02%), Query Frame = 2 
Query:   95 GPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSI----IDKESGDDQKHRQTRGGKG--QIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            GP EGV YP+ +KYCG C +P EYCE+    EKCK+WLE ++P+++E+L I       +  DD K RQ RGGKG  ++KKK++V  +I +SRA+RG+KK VTV+TGL+T+ IDLKVA+K FG KFA GSSVTG DEIVIQGD+KDDL D I EKW EIDE+ IEDLGD KR
Sbjct:   18 GPREGVTYPIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRVKKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWAEIDEDVIEDLGDQKR 188
[Close]
BLAST of Density-regulated protein vs. UniProt/SwissProt
Match: sp|Q5ZJ39|DENR_CHICK (Density-regulated protein OS=Gallus gallus OX=9031 GN=DENR PE=2 SV=1)

HSP 1 Score: 182.956 bits (463), Expect = 2.832e-57
Identity = 94/182 (51.65%), Postives = 128/182 (70.33%), Query Frame = 2 
Query:   86 VYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESG----------DDQKHRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            + SG     DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P+E+ KL++ +   +E+G          +++K +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   17 IRSGARSDADYPLRVLYCGVCSLPTEYCEYMPDVTKCRQWLEKNFPDEFAKLTVENSPKQEAGVGEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. UniProt/SwissProt
Match: sp|O43583|DENR_HUMAN (Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2)

HSP 1 Score: 181.415 bits (459), Expect = 1.058e-56
Identity = 91/174 (52.30%), Postives = 121/174 (69.54%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESGDDQKH----------RQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G  +            +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. UniProt/SwissProt
Match: sp|Q2HJ47|DENR_BOVIN (Density-regulated protein OS=Bos taurus OX=9913 GN=DENR PE=2 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 1.565e-56
Identity = 91/174 (52.30%), Postives = 121/174 (69.54%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESGDDQKH----------RQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G  +            +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. UniProt/SwissProt
Match: sp|Q9CQJ6|DENR_MOUSE (Density-regulated protein OS=Mus musculus OX=10090 GN=Denr PE=1 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 1.635e-56
Identity = 92/174 (52.87%), Postives = 124/174 (71.26%), Query Frame = 2 
Query:  110 VDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESG----------DDQKHRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
             DYPL V YCG C LPTEYCE+  +V KC+QWLEKN P E+ KL++ +   +E+G          +++K +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVTG DEI+IQGD  DD+ID I EKWPE+D+++IEDLG+ K+
Sbjct:   25 ADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK 198
[Close]
BLAST of Density-regulated protein vs. TrEMBL
Match: A0A419PYF8 (Density-regulated protein OS=Clonorchis sinensis OX=79923 GN=DENR PE=4 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 1.010e-69
Identity = 104/177 (58.76%), Postives = 135/177 (76.27%), Query Frame = 2 
Query:   68 NNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID--KESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTG-ADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            ++Y+++  S PV GV+YPL V YCGEC +P EYCEF +  +KC+ W+EKNLPEE+E+L+  D    +    K RQ RGGKG   +K   + KI + + SRG+KKF T + GL+T+GI+LKVASKVFGQKFATGSSVTG  DEIVIQGD+KD++ID + EKWPEIDE++IEDLG+ KR
Sbjct:    3 SDYQYMPRSRPVPGVEYPLTVAYCGECTMPIEYCEFSSAPDKCRSWMEKNLPEEFERLTACDGAPPAEAPAKGRQVRGGKGSAPRKP-AKQKITVFKTSRGKKKFTTSVVGLSTFGIELKVASKVFGQKFATGSSVTGNGDEIVIQGDVKDEIIDLLTEKWPEIDEDSIEDLGEMKR 178
[Close]
BLAST of Density-regulated protein vs. TrEMBL
Match: A0A4S2M2U1 (SUI1 domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_004351 PE=4 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 1.067e-69
Identity = 104/177 (58.76%), Postives = 135/177 (76.27%), Query Frame = 2 
Query:   68 NNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID--KESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTG-ADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            ++Y+++  S PV GV+YPL V YCGEC +P EYCEF +  +KC+ W+EKNLPEE+E+L+  D    +    K RQ RGGKG   +K   + KI + + SRG+KKF T + GL+T+GI+LKVASKVFGQKFATGSSVTG  DEIVIQGD+KD++ID + EKWPEIDE++IEDLG+ KR
Sbjct:    3 SDYQYMPRSQPVPGVEYPLTVAYCGECTMPIEYCEFSSAPDKCRSWMEKNLPEEFERLTACDGAPPAEAPAKGRQVRGGKGSAPRKP-AKQKITVFKTSRGKKKFTTSVVGLSTFGIELKVASKVFGQKFATGSSVTGNGDEIVIQGDVKDEIIDLLTEKWPEIDEDSIEDLGEMKR 178
[Close]
BLAST of Density-regulated protein vs. TrEMBL
Match: A0A1S8WQF2 (Density-regulated protein DRP1 OS=Opisthorchis viverrini OX=6198 GN=X801_07497 PE=4 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 1.067e-69
Identity = 104/177 (58.76%), Postives = 135/177 (76.27%), Query Frame = 2 
Query:   68 NNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID--KESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTG-ADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            ++Y+++  S PV GV+YPL V YCGEC +P EYCEF +  +KC+ W+EKNLPEE+E+L+  D    +    K RQ RGGKG   +K   + KI + + SRG+KKF T + GL+T+GI+LKVASKVFGQKFATGSSVTG  DEIVIQGD+KD++ID + EKWPEIDE++IEDLG+ KR
Sbjct:    3 SDYQYMPRSRPVPGVEYPLTVAYCGECTMPIEYCEFSSAPDKCRSWMEKNLPEEFERLTACDGAPPAEAPAKGRQVRGGKGSAPRKP-AKQKITVFKTSRGKKKFTTSVVGLSTFGIELKVASKVFGQKFATGSSVTGNGDEIVIQGDVKDEIIDLLTEKWPEIDEDSIEDLGEMKR 178
[Close]
BLAST of Density-regulated protein vs. TrEMBL
Match: A0A131YHX1 (Density-regulated protein OS=Rhipicephalus appendiculatus OX=34631 PE=3 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 4.419e-69
Identity = 108/175 (61.71%), Postives = 134/175 (76.57%), Query Frame = 2 
Query:   86 VYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEK-LSIIDKES----GDDQKHRQTRGGKGQIKKKKEVEH--KIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            + +GP+ GV YPL V YCGEC +P EYCE+  + +KCK+WL+KNLPEE+E+ L++ D       GD++K RQ RGGKG +K KK VE   +I +SRASRG+KKFVTV+TGL+T+ IDLK ASK F  KF+ GSSVTG DEIVIQGD+KDD+ D I EKWPEID+E IEDLGD  R
Sbjct:    9 LSTGPLPGVSYPLEVIYCGECSMPLEYCEYYPDSQKCKEWLQKNLPEEFERRLNLSDAPQTGAGGDEEKKRQKRGGKGMVKAKKRVEKDKRICLSRASRGKKKFVTVVTGLSTFDIDLKDASKFFSHKFSCGSSVTGDDEIVIQGDVKDDIFDVITEKWPEIDDELIEDLGDQSR 183
[Close]
BLAST of Density-regulated protein vs. TrEMBL
Match: A0A1S3DBV5 (Density-regulated protein OS=Diaphorina citri OX=121845 GN=LOC103515568 PE=3 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 4.517e-69
Identity = 110/172 (63.95%), Postives = 133/172 (77.33%), Query Frame = 2 
Query:   92 SGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDD----QKHRQTRGGKGQIK--KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            +GP EGV+YP++V YCG C LP EYCE+    EKCK WLEKNLPEE+EKL  +  + GD+    +K RQ RGGKG +K  KK+EV  ++ +SRA RG+KK VTV+TGL+++ IDLKVASK FG +FA GSSVTG DEIVIQGD+KDDL D I EKWPEIDE+ IEDLGD KR
Sbjct:   12 NGPQEGVNYPISVLYCGNCSLPVEYCEYHPEYEKCKVWLEKNLPEEFEKLVKLSGDGGDEDATEEKKRQKRGGKGIVKARKKEEVPKQVCVSRAPRGKKKSVTVVTGLSSFDIDLKVASKFFGTRFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWPEIDEDFIEDLGDLKR 183
[Close]
BLAST of Density-regulated protein vs. Ensembl Cavefish
Match: denr (density regulated re-initiation and release factor [Source:NCBI gene;Acc:103044519])

HSP 1 Score: 167.548 bits (423), Expect = 3.816e-52
Identity = 85/178 (47.75%), Postives = 115/178 (64.61%), Query Frame = 2 
Query:  116 YPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQK-------------------HRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            YPL V YCG C LPTEYCE+     KC+QWLEKN P+ + ++++  K S   Q+                    +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVT  DEI+IQGD  DD+ID I EKWPE+D+++I+DLG+ K+
Sbjct:   25 YPLKVLYCGVCSLPTEYCEYMPEPAKCRQWLEKNFPDVFARMTL-GKGSAPKQETGGGGGGGEAPPAVEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK 201
[Close]
BLAST of Density-regulated protein vs. Ensembl Cavefish
Match: denr (density regulated re-initiation and release factor [Source:NCBI gene;Acc:103044519])

HSP 1 Score: 142.51 bits (358), Expect = 1.771e-42
Identity = 74/169 (43.79%), Postives = 107/169 (63.31%), Query Frame = 2 
Query:  143 ECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQK-------------------HRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            + + P +YCE+     KC+QWLEKN P+ + ++++  K S   Q+                    +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVT  DEI+IQGD  DD+ID I EKWPE+D+++I+DLG+ K+
Sbjct:   22 DAKYPLKYCEYMPEPAKCRQWLEKNFPDVFARMTL-GKGSAPKQETGGGGGGGEAPPAVEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK 189
[Close]
BLAST of Density-regulated protein vs. Ensembl Sea Lamprey
Match: denr (density-regulated protein [Source:NCBI gene;Acc:436970])

HSP 1 Score: 140.584 bits (353), Expect = 2.047e-42
Identity = 79/165 (47.88%), Postives = 105/165 (63.64%), Query Frame = 2 
Query:  107 GVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESG----------------DDQKHRQTRGGKGQIKKKKE-VEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEI 550
             V YP+ V YCGEC LP EYCE+     KCKQW E+N P+E+ KL++     G                +D+K RQ RGGKGQIK+KK+ V  KI I++  R +KK+VT + GL T+ I+LK A K+F Q+F+ G+SVT  DEI IQGD+ D ++D I EKW E+
Sbjct:   26 NVSYPMKVLYCGECSLPIEYCEYMPQYAKCKQWWERNFPDEFAKLNLGGGGGGGGGEVGGGETQEGVIEEDEKKRQKRGGKGQIKQKKKTVPQKITIAKIPRAKKKYVTRVCGLATFDIELKEAQKLFAQRFSCGASVTAEDEITIQGDVTDSIMDVIQEKWSEV 190
[Close]
BLAST of Density-regulated protein vs. Ensembl Yeast
Match: TMA22 (Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003775])

HSP 1 Score: 90.1225 bits (222), Expect = 5.171e-23
Identity = 53/162 (32.72%), Postives = 82/162 (50.62%), Query Frame = 2 
Query:  128 VKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID------------------------KESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVT----GADEIVIQGDIKDDLIDFI 529
            V YCG C  P EYCEF   +++CK WL +N  + Y KL   D                        K   D  K ++ +  + Q +  K++  K+ I R +R ++KF+  I+GL  + ID+K  +K F  +FATG SV+      +E+VIQGD+ D++  +I
Sbjct:    5 VIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTNKLAESSIGEAREEKLEKDLLKIQKKQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYI 166
[Close]
BLAST of Density-regulated protein vs. Ensembl Nematostella
Match: EDO41317 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4N9])

HSP 1 Score: 185.267 bits (469), Expect = 1.047e-59
Identity = 91/169 (53.85%), Postives = 120/169 (71.01%), Query Frame = 2 
Query:  104 EGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESG-----DDQKHRQTRGGKGQIKKKKEVEHKI--AISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            E + YPL V YCG C LP EYCEF    EKCK+WL++NLP+ Y++++   ++ G     D  + RQTRGGKGQ+K  K+        +SR  R +KK+VT++TGL+T+ IDLK ASK F  +F+ G+SVTG D+I IQGD+ DDL DFI +KWPEIDE++IEDLGD KR
Sbjct:   20 ENISYPLTVHYCGVCTLPLEYCEFSPESEKCKEWLKENLPDVYDEMNEAAEQMGALDINDASRKRQTRGGKGQLKLPKKKNVPKKVCLSRTQRNKKKYVTIVTGLSTFEIDLKKASKAFANRFSCGASVTGDDKIEIQGDVTDDLWDFIPDKWPEIDEDSIEDLGDVKR 188
[Close]
BLAST of Density-regulated protein vs. Ensembl Medaka
Match: denr (density regulated re-initiation and release factor [Source:NCBI gene;Acc:101169300])

HSP 1 Score: 153.295 bits (386), Expect = 8.075e-47
Identity = 81/171 (47.37%), Postives = 114/171 (66.67%), Query Frame = 2 
Query:  116 YPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIID---KESG---------DDQKHRQTRGGKGQIK-KKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            YPL V YCG       YCE+     KC+QWLEKN P+ + ++++     +ESG         +++K +Q RGG+GQIK KKK V  K+ I++  R +KK+VT + GL T+ IDLK A + F QKF+ G+SVT  DEI+IQGD  DD+ID I EKWPE+D+++I+DLG+ K+
Sbjct:   21 YPLKVLYCG-----GTYCEYMPEPAKCRQWLEKNFPDVFARMTVAKAPKQESGTGEAPPAGEEEEKKKQKRGGRGQIKQKKKAVPQKVTIAKIPRAKKKYVTRVCGLATFDIDLKEAQRFFAQKFSCGASVTAEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIDDLGEVKK 186
[Close]
BLAST of Density-regulated protein vs. Planmine SMEST
Match: SMESG000077900.1 (SMESG000077900.1)

HSP 1 Score: 355.91 bits (912), Expect = 4.120e-127
Identity = 175/175 (100.00%), Postives = 175/175 (100.00%), Query Frame = 2 
Query:   65 MNNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 589
            MNNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR
Sbjct:    1 MNNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEKNLPEEYEKLSIIDKESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRGRKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDDLIDFIIEKWPEIDEETIEDLGDAKR 175
The following BLAST results are available for this feature:
BLAST of Density-regulated protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
DENR2.203e-5752.30density regulated re-initiation and release factor... [more]
DENR2.040e-3548.12density regulated re-initiation and release factor... [more]
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BLAST of Density-regulated protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Y47D3A.211.425e-5047.80Density-regulated protein homolog [Source:UniProt... [more]
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BLAST of Density-regulated protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
DENR3.146e-6160.82gene:FBgn0030802 transcript:FBtr0310520[more]
DENR3.146e-6160.82gene:FBgn0030802 transcript:FBtr0074347[more]
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BLAST of Density-regulated protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
denr5.210e-5044.57density-regulated protein [Source:NCBI gene;Acc:43... [more]
denr5.210e-5044.57density-regulated protein [Source:NCBI gene;Acc:43... [more]
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BLAST of Density-regulated protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
denr1.467e-5550.87density-regulated protein [Source:NCBI gene;Acc:44... [more]
denr1.169e-4648.84density-regulated protein [Source:NCBI gene;Acc:44... [more]
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BLAST of Density-regulated protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Denr2.338e-5752.87density-regulated protein [Source:MGI Symbol;Acc:M... [more]
Denr2.743e-4951.90density-regulated protein [Source:MGI Symbol;Acc:M... [more]
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BLAST of Density-regulated protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VX98|DENR_DROME3.154e-6060.82Density-regulated protein homolog OS=Drosophila me... [more]
sp|Q5ZJ39|DENR_CHICK2.832e-5751.65Density-regulated protein OS=Gallus gallus OX=9031... [more]
sp|O43583|DENR_HUMAN1.058e-5652.30Density-regulated protein OS=Homo sapiens OX=9606 ... [more]
sp|Q2HJ47|DENR_BOVIN1.565e-5652.30Density-regulated protein OS=Bos taurus OX=9913 GN... [more]
sp|Q9CQJ6|DENR_MOUSE1.635e-5652.87Density-regulated protein OS=Mus musculus OX=10090... [more]
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BLAST of Density-regulated protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A419PYF81.010e-6958.76Density-regulated protein OS=Clonorchis sinensis O... [more]
A0A4S2M2U11.067e-6958.76SUI1 domain-containing protein OS=Opisthorchis fel... [more]
A0A1S8WQF21.067e-6958.76Density-regulated protein DRP1 OS=Opisthorchis viv... [more]
A0A131YHX14.419e-6961.71Density-regulated protein OS=Rhipicephalus appendi... [more]
A0A1S3DBV54.517e-6963.95Density-regulated protein OS=Diaphorina citri OX=1... [more]
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BLAST of Density-regulated protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
denr3.816e-5247.75density regulated re-initiation and release factor... [more]
denr1.771e-4243.79density regulated re-initiation and release factor... [more]
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BLAST of Density-regulated protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
denr2.047e-4247.88density-regulated protein [Source:NCBI gene;Acc:43... [more]
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BLAST of Density-regulated protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
TMA225.171e-2332.72Protein of unknown function; associates with ribos... [more]
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BLAST of Density-regulated protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO413171.047e-5953.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Density-regulated protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
denr8.075e-4747.37density regulated re-initiation and release factor... [more]
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BLAST of Density-regulated protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000077900.14.120e-127100.00SMESG000077900.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013663 ID=SMED30013663|Name=Density-regulated protein|organism=Schmidtea mediterranea sexual|type=transcript|length=634bp
GTTTTTTAAATAAATTTTTTAGTCGTCAAATAATTTTTAACATATTTCAA
TTTTTTTTCGACAAATGAACAATTATGAATTTTTAGTATACTCTGGGCCT
GTTGAAGGGGTCGATTACCCGTTGAATGTTAAATATTGCGGAGAATGTGA
ATTACCTACTGAGTACTGTGAATTTGGAGCAAATGTTGAAAAGTGTAAAC
AATGGCTAGAAAAAAATTTGCCAGAAGAATATGAAAAGTTATCAATAATT
GATAAAGAATCAGGAGATGATCAGAAGCATAGACAAACTAGAGGTGGAAA
AGGACAAATTAAAAAGAAGAAAGAAGTCGAACATAAAATTGCAATTTCCC
GAGCAAGTAGAGGTAGAAAGAAGTTCGTTACAGTTATTACTGGGTTAACA
ACTTATGGAATTGATTTAAAAGTTGCATCTAAAGTCTTCGGTCAAAAATT
TGCAACAGGTAGTTCTGTTACTGGTGCAGATGAAATTGTTATTCAAGGCG
ATATCAAAGATGATTTGATTGATTTTATAATAGAAAAATGGCCAGAAATC
GACGAAGAAACTATTGAAGATTTAGGAGATGCAAAGCGTTAATTGCTTTT
ATAAATAATAAATGTGATTTGTTTTGAAAAAAAA
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protein sequence of SMED30013663-orf-1

>SMED30013663-orf-1 ID=SMED30013663-orf-1|Name=SMED30013663-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=176bp
MNNYEFLVYSGPVEGVDYPLNVKYCGECELPTEYCEFGANVEKCKQWLEK
NLPEEYEKLSIIDKESGDDQKHRQTRGGKGQIKKKKEVEHKIAISRASRG
RKKFVTVITGLTTYGIDLKVASKVFGQKFATGSSVTGADEIVIQGDIKDD
LIDFIIEKWPEIDEETIEDLGDAKR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR005873DENR_eukaryotes
IPR036877SUI1_dom_sf
IPR001950SUI1
Vocabulary: molecular function
TermDefinition
GO:0003743translation initiation factor activity
GO:0003729mRNA binding
GO:0043022ribosome binding
Vocabulary: biological process
TermDefinition
GO:0006413translational initiation
GO:0001731formation of translation preinitiation complex
GO:0002188translation reinitiation
GO:0002192IRES-dependent translational initiation
GO:0006417regulation of translation
GO:0008284positive regulation of cell proliferation
GO:0035076ecdysone receptor-mediated signaling pathway
GO:0045948positive regulation of translational initiation
GO:0046628positive regulation of insulin receptor signaling pathway
Vocabulary: cellular component
TermDefinition
GO:0043234protein complex
GO:0070992translation initiation complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001950SUI1 domainPFAMPF01253SUI1coord: 90..158
e-value: 1.3E-18
score: 67.3
IPR001950SUI1 domainPROSITEPS50296SUI1coord: 92..159
score: 17.972
NoneNo IPR availableGENE3DG3DSA:3.30.780.10coord: 49..168
e-value: 7.5E-16
score: 60.5
NoneNo IPR availablePANTHERPTHR12789:SF0DENSITY-REGULATED PROTEINcoord: 17..175
NoneNo IPR availablePANTHERPTHR12789DENSITY-REGULATED PROTEIN HOMOLOGcoord: 17..175
NoneNo IPR availableCDDcd11607DENR_Ccoord: 91..171
e-value: 2.15153E-40
score: 129.6
IPR005873DENR family, eukaryotesTIGRFAMTIGR01159TIGR01159coord: 29..171
e-value: 3.8E-37
score: 125.8
IPR036877SUI1 domain superfamilySUPERFAMILYSSF55159eIF1-likecoord: 31..169