Ubiquitin protein ligase

Overview


Name	Ubiquitin protein ligase
Smed ID	SMED30013617
Length (bp)	3392

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Ubiquitin protein ligase (SMED30013617) t-SNE clustered cells

Violin plots show distribution of expression levels for Ubiquitin protein ligase (SMED30013617) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Ubiquitin protein ligase (SMED30013617) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Ubiquitin protein ligase (SMED30013617) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013617

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
cephalic ganglia	SMED30013617	h1SMcG0006850	DN307143	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
ventral nerve cord	SMED30013617	h1SMcG0006850	DN307143	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
neoblast	SMED30013617	h1SMcG0006850	DN307143	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
parenchymal cell	SMED30013617	h1SMcG0006850	DN307143	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
Category 2 cell	SMED30013617	h1SMcG0006850	GAKN01016992.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
central nervous system	SMED30013617	h1SMcG0006850	GAKN01016992.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
neoblast	SMED30013617	h1SMcG0006850	GAKN01016992.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
parenchyma	SMED30013617	h1SMcG0006850	GAKN01016992.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015

Note: Hover over icons to view figure legend

Homology

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BLAST of Ubiquitin protein ligase vs. Ensembl Human
Match: UBE3C (ubiquitin protein ligase E3C [Source:HGNC Symbol;Acc:HGNC:16803])

HSP 1 Score: 337.806 bits (865), Expect = 4.244e-98
Identity = 219/640 (34.22%), Postives = 343/640 (53.59%), Query Frame = 2

Query: 1493 RRLWG--SAVEQKTKDGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQD----LDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIEL-QRVVIRLYN--RDVRKGLKMSGKRLEWVKPGLCRINVENFK------------RYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW   S++  +   G +  L+Q +  G   S + D          F++     L+S+ D     D I++  +  S ++ F+ +EL  +   LRD   G+I L YP        +  T   S  + T   ++  I++ Q+  I+L+    ++ K LK    R  +  P       E+ K            R+        + G ++S+         ++ S+ RQ+ +L E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++Y+NLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LNRQI +       GL +VV +E  ++FD  EI  +I+G    I L+DL+  T Y G    D   +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   +R KLLYAI   +GF+
Sbjct:  457 RHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFE-DSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSA---DVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHP-VIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081

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BLAST of Ubiquitin protein ligase vs. Ensembl Human
Match: UBE3B (ubiquitin protein ligase E3B [Source:HGNC Symbol;Acc:HGNC:13478])

HSP 1 Score: 256.144 bits (653), Expect = 7.189e-70
Identity = 146/434 (33.64%), Postives = 243/434 (55.99%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  +IL+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q+++ +   ++  ++++F++  G++E G+D  G+ +EFL  IIK   DP   LF +T  +  +YP+P   +   +N+ +  +F G+MLG  +++G++V+  FA FF+ +L  +  S     +D L  LD + Y+NL S+K  D  + ++ L  +      G     EL P G+ I VTN NKI YI+L+A ++++ QI  QT+ +I+G   ++  E  ++F   E+  +I+G ++ IDL+DL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +REKL YAI  ++GF+
Sbjct:  636 RAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPT--SYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYG-GFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066

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Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  +IL+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q+++ +   ++  ++++F++  G++E G+D  G+ +EFL  IIK   DP   LF +T  +  +YP+P   +   +N+ +  +F G+MLG  +++G++V+  FA FF+ +L  +  S     +D L  LD + Y+NL S+K  D  + ++ L  +      G     EL P G+ I VTN NKI YI+L+A ++++ QI  QT+ +I+G   ++  E  ++F   E+  +I+G ++ IDL+DL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +REKL YAI  ++GF+
Sbjct:  636 RAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPT--SYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYG-GFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066

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BLAST of Ubiquitin protein ligase vs. Ensembl Human
Match: WWP2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804])

HSP 1 Score: 184.882 bits (468), Expect = 5.604e-50
Identity = 125/369 (33.88%), Postives = 191/369 (51.76%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L I  I R    E G+D GG+ RE+   +  E  +P   LF  + KNN         ++ PD    HL +F   GR + + ++ G  ++  F   F +++ N   +     + +L+ +D + Y +++ +K  + +EE  L+  F       G   T ELK  GE I VT  NK EYI L+ D++  R + +QT   ++G N+V P+E  + FD  E+  ++ G    ID+ D Q++TIY       +S+ IQ FW+V+ EM  +++   +QFVT   R P+ GF+EL       KF I  V     LP + TC N L LP Y++ E++REKLLYAI    GF
Sbjct:   78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYI--IMR---GEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD----HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPT-----LKDLESIDPEFYNSIVWIKE-NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQE-IDMSDWQKSTIYRHYT--KNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428

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BLAST of Ubiquitin protein ligase vs. Ensembl Human
Match: NEDD4L (NEDD4 like E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7728])

HSP 1 Score: 181.415 bits (459), Expect = 3.925e-47
Identity = 127/390 (32.56%), Postives = 213/390 (54.62%), Query Frame = 2

Query: 2144 KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKR-KTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITG-GDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            K+L    + P  F M    ++ R+ ++E+++ +I   K    L++ L IEF      +E G+D GG+ RE+   + KE  +P  GLF   +T N  +  NP       D    HL +F   GR+ GL +F G L++  F  PF+   L       ++I +++++ +D + Y +L  +   D  E ++L F +    +G +  V+LKPNG  I VTN NK EYI LV  ++   ++ KQ +  + G  +++PI+  ++FD +E+  ++ G GD  +D++D ++++IY     P+   +IQ FW+ +  M  +++   +QFVT  SR PM GF+EL     P+ F I+     ++LP A TC N L LP Y+  E++REKLL A+ +  GF+
Sbjct:  270 KKLKKPADIPNRFEM----KLHRNNIFEESYRRIMSVKRPDVLKARLWIEF-----ESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNED----HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML------GKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD--VDVNDWRQHSIYKNGYCPNHP-VIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 636

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BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
Match: etc-1 (E3 ubiquitin-protein ligase etc-1 [Source:UniProtKB/Swiss-Prot;Acc:O17736])

HSP 1 Score: 273.863 bits (699), Expect = 1.225e-76
Identity = 178/592 (30.07%), Postives = 306/592 (51.69%), Query Frame = 2

Query: 1625 FANCLHWRLLSVQDLDLIKID-SEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQI------CTEKLVKMFIELQRVVIRL----------YNRDVRKGL---------KMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG---MNYPTSFAM---IPPIRIRRDYLYEDAFSQIKRK----TFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVE--EINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNT---IYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDT-DRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            F NCL+ R+ SV D D +  D   D    +EF           LRD+   LI L++P + +      N     ++        TE +  +   + +  IRL          + R+V  G+         +M   RL+ ++  +    VE     +E    +        + + +   R I ++K +PFI+P   R+KLF  LL      +Y ++F M    P + +RRD +Y DAF     K       +L+S ++++ ++  GMNE G+DGGG+ REFL  ++K A + +RG F  T++ L+YPNP    L   +   H  F GRM+G +I++  L E  FA FFI ++F    ++ ++D+ +++  D  ++++L +L+ M+  E  E+ LDF+V  S  G+ + V LKPNG    VT  N  EY+ L  +Y L ++I+     +  G+++++ IE  ++F   E+  +I G + +    +L++        G  D +  E+   FW V+ ++S D+K+  ++FVT  SRAP+ GF  + P+  + ++P + D LPT++TC+N+L++P Y N  ++ EKL YAI S +GF+
Sbjct:  424 FCNCLNKRVSSVADSDFVPTDIFVDFDHTVEF-----------LRDVSIKLIHLMFPTMARGDLYSGNLKEKMYKAETDWKDVTESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMPRRRMPNGRLQ-IERTMDTEFVERLAAIYEMDSDSENDDEDEDNNLPAVLRRAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVTVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNK-DVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELRFAAGTQDINYEEM---FWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFE 999

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BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
Match: oxi-1 (OXidative stress Induced [Source:UniProtKB/TrEMBL;Acc:Q9XXE6])

HSP 1 Score: 234.958 bits (598), Expect = 2.514e-63
Identity = 153/507 (30.18%), Postives = 261/507 (51.48%), Query Frame = 2

Query: 1871 MFIELQRVVIRLYNRDVRKGLKMSGKRLEW----VKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTSFAMIPP-----IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMD-RVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            +F  +  ++  LY RD R+    +  +  W    VKP               SL I Y+              + ++++++M  ++PI  RM LF+  +       + ++  P     I ++R+ + ED F+ + + T   L+S ++++F++  G++E G+D  G+ +EFL   +K+  DP+  LF +T   ++YP+P   +L+ D    HL  F   GRMLG  +++G++V+   AP  +  +     S      D L  LD +LYR+L  +K  +  + +++L F+V     G   TV+L P+G  ISVTN NKI+Y++ +A +++ R+  +Q    + G+  ++      LF  +++  +I+G +S IDL DL+RN  Y G     +  +I+  W +L  + + +E++ F++FVTS SR P+LGFS L P F+I+ V  +D                         RLPTASTC NLLKLP Y     + EKL YAI + +GF+
Sbjct:  592 LFHSMHSLLTVLYERDSRRSFAANDSKF-WLISEVKPS--------------SLTIEYE----------KKSGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRVATSLNDPQMQTWITVQRNRIIEDGFNHLSKLTIPALKSTIRVKFVNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNLFSTTSTGVLYPSPT-SSLHDD----HLALFTFVGRMLGKAVYEGIVVDVQLAPVLLAAVLG---SHRLCAFDELSQLDPELYRSLTFVKRYEGEMADLSLTFSVDEDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQPTWLSLFAPNDLQCLISGVNSDIDLADLKRNVQYFG-GFHGNHRLIKWLWDILENKFTSEERKLFLKFVTSCSRPPVLGFSYLEPPFSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNLLKLPNYNKKSLLLEKLRYAIHAGTGFE 1064

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BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
Match: Y92H12A.2 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:Q9BKW4])

HSP 1 Score: 196.823 bits (499), Expect = 8.262e-54
Identity = 129/361 (35.73%), Postives = 197/361 (54.57%), Query Frame = 2

Query: 2204 IRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELS-----PKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAI 3253
            + RD L+ED++  I  K   +LR+ L IEF   FG  E G+D GG+ RE+   +  +  +P  GLF   +T N  +  NP  E   P    EHL +F   GR++G+ I+ G L++A F  PF+   L       ++I + +++ +D + Y +L+ +K  D  + + L F++  S +G +Q +EL PNG ++ VT  NK EYI  V  ++   +I KQ + I+ GL +VVP    +LFD +E+  ++ G    ID+ D + NTIY G   P SS+++  FW+ +     + +   +QFV+  SR PM GF EL       KF I+     D LP A TC N L LP Y   +E++ KLL AI
Sbjct:  144 VHRDTLFEDSYRHIMDKKDYDLRNKLWIEF---FG--ETGLDYGGVTREWFFLLSHQIFNPYYGLFEYSATDNYTLQINPHSEACNP----EHLSYFHFIGRIIGMAIYHGKLLDAFFIRPFYKMML------GKKITLFDMESVDNEYYNSLIYVKDNDPAD-LELTFSLDDSIFGETQNIELIPNGANVPVTEDNKEEYIEAVISWRFVNRIEKQMNQILKGLQEVVPSNLLRLFDANELELLMCGLQK-IDVKDWKANTIYKGGYGP-SSQVVHNFWKCILSFDNEMRARVLQFVSGTSRVPMNGFRELYGSNGLQKFTIERWGSADMLPRAHTCFNRLDLPPYTTFKELKSKLLTAI 486

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BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 184.496 bits (467), Expect = 1.520e-49
Identity = 117/367 (31.88%), Postives = 199/367 (54.22%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN--LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R+ ++ED+F +I RK   +LR  L I+F       E G+D GG+ RE+   +  E  +P   LF+   NN   +  NP    + PD+  ++ ++ GR + + +F G  + + F   F +K+ N     ++I + +++ +D ++Y +L+ +K  + ++E +++  F       G  +T ELK  G  I+VT  NK+EYI L+ +++ NR + +QT     G N V P+E  Q FD  E+  ++ G    +D+DD QRNT+Y     P S ++   FW+ +  + ++++   +QFVT   R P+ GFSEL     P+ F I+ V   + LP + TC N L LP Y++ +++ EKL  AI    GF
Sbjct:  154 ITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQF-----RGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINP-ASFVNPDH-LKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLN-----KKIVLKDIEQVDSEIYNSLMWIKD-NNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQD-VDVDDWQRNTVYRHY-APQSKQVT-WFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 504

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Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN--LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R+ ++ED+F +I RK   +LR  L I+F       E G+D GG+ RE+   +  E  +P   LF+   NN   +  NP    + PD+  ++ ++ GR + + +F G  + + F   F +K+ N     ++I + +++ +D ++Y +L+ +K  + ++E +++  F       G  +T ELK  G  I+VT  NK+EYI L+ +++ NR + +QT     G N V P+E  Q FD  E+  ++ G    +D+DD QRNT+Y     P S ++   FW+ +  + ++++   +QFVT   R P+ GFSEL     P+ F I+ V   + LP + TC N L LP Y++ +++ EKL  AI    GF
Sbjct:  154 ITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQF-----RGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINP-ASFVNPDH-LKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLN-----KKIVLKDIEQVDSEIYNSLMWIKD-NNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQD-VDVDDWQRNTVYRHY-APQSKQVT-WFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 504

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BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Match: CG3356 (gene:FBgn0034989 transcript:FBtr0072262)

HSP 1 Score: 356.681 bits (914), Expect = 7.831e-105
Identity = 227/635 (35.75%), Postives = 357/635 (56.22%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTKDG---DLTLMQSLILGQIRSIDTDMK------EFFGKLLCFANCLHWRLLSVQDLDLIKIDSE-DSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLI--NQSKYNQ--PNTVANSHQICTEKLVKMFIELQRVVI----RLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQ---------------VTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPT-----SFAMIPP--IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMD-RVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R +W     + T+ G    LTL+   ++ + + +D  +         FG+LL   + + +    V++  L+++ S  +  +++ FS  E+ ++   L+DI  GL+ L +P    N + Y +   +T A+  ++  +K  +++  L  VV+    +++ RD+R G         W    + R+++   +     L  + +   IR  Q               +++   R I IL+E+PF++P   R+ + + L+            +F   P   I +RR +LYEDA+ +++     +LR   +I+F+   G++E G+DGGG+ REFL  +IK A DP RG F+ T +N +YPNP +  L+ D +++H  F GR+LG  I++ LLVE   A FF+ KL    S   ++DI  L  LD +LYRNLL LK     V E+NLDFTV+ S  G +Q VELKP G+ I VTNSN+IEY+ L+ADYKLN QI +  +    GL++V+PIE   +F   E+  +I+G +  IDL+DL+++  Y G   P+   I+ TFW VL    + ++R  ++FVTS SR P+LGF +L P F IQ   D +RLPTASTC NLLKLP ++ +E+MREKLLYAI S +GF+
Sbjct:  503 RAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEF----VENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQK--QIWANLLNVVVFVLNQIHTRDLRLGFCPED---HWT---VTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYS---DVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIV-TFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFE 1120

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BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Match: CG5087 (gene:FBgn0035953 transcript:FBtr0333908)

HSP 1 Score: 256.529 bits (654), Expect = 2.813e-70
Identity = 175/556 (31.47%), Postives = 281/556 (50.54%), Query Frame = 2

Query: 1712 EFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL-EWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPP---IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            E +P +L + VL    + Y L  ++Y LIN +     N V +           +F+ L  +++ LY RD R+        L   VKP     ++E  KR                          +++L +MP IIP   R+KLF++ +      M    S    P    I I RD + ED + Q+  +    L+  +++ FI++ G++E G+D  G+ +EFL   IK+  DP   LF +T +  +YP+P   +   DN  E  +F GRMLG  +++G++V+  FA FF+ +L   +       +D L  LD +LYR+L  +K   + V ++NL F+V +   G   T+ L P G+   V + NK+ YI+ +A + +N QI +QT     G   +V  E   LF   E+  +I+G  S +DL DLQ++T Y+G    D+ +++   W +L  + +E+E++ F++FVTS S+ P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP YQ    +R+KL YA+ S++GF+
Sbjct:  561 EQNPFKLNDYVL----LTYFLNNILYKLINDNLLGAKNIVQHP----------VFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKR------------------------NAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPI--SYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYG-GFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFE 1075

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BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Match: CG5087 (gene:FBgn0035953 transcript:FBtr0076520)

HSP 1 Score: 256.144 bits (653), Expect = 3.444e-70
Identity = 176/556 (31.65%), Postives = 282/556 (50.72%), Query Frame = 2

Query: 1712 EFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL-EWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPP---IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            E +P +L + VL    + Y L  ++Y LIN       N +A +  I       +F+ L  +++ LY RD R+        L   VKP     ++E  KR                          +++L +MP IIP   R+KLF++ +      M    S    P    I I RD + ED + Q+  +    L+  +++ FI++ G++E G+D  G+ +EFL   IK+  DP   LF +T +  +YP+P   +   DN  E  +F GRMLG  +++G++V+  FA FF+ +L   +       +D L  LD +LYR+L  +K   + V ++NL F+V +   G   T+ L P G+   V + NK+ YI+ +A + +N QI +QT     G   +V  E   LF   E+  +I+G  S +DL DLQ++T Y+G    D+ +++   W +L  + +E+E++ F++FVTS S+ P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP YQ    +R+KL YA+ S++GF+
Sbjct:  561 EQNPFKLNDYVL----LTYFLNNILYKLIND------NLLAGAKNIVQHP---VFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKR------------------------NAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPI--SYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYG-GFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFE 1076

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BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Match: Nedd4 (gene:FBgn0259174 transcript:FBtr0300520)

HSP 1 Score: 177.178 bits (448), Expect = 3.751e-45
Identity = 130/386 (33.68%), Postives = 202/386 (52.33%), Query Frame = 2

Query: 2165 NYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNL-RSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNW-----QEHLDFF---GRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMD-RVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            N P  F     IRIRR  + ED++  I   T T+L ++ L +EF       E G+D GGL RE+   + KE  +P  GLF  S  +N         TL  +N      +EHL +F   GR+ G+ ++ G L++A F  PF+   L      ++ ID+ +++ +D + Y +L+ +K  D R+  + L F +    +G     ELKP G +I VTN NK EYI LV +++   ++ +Q S  ++G   ++P+   ++FD  E+  ++ G  + ID+ D + NT+Y G D   +  IIQ FWR +   S + +   +QFVT  SR PM GF EL     P+ F I+     +  P A TC N L LP Y+   ++++KL+ AI    GF
Sbjct:  472 NVPNKFE----IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEF-----EGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNY--------TLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML------QKPIDLKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQN-IDVKDWRENTLYKG-DYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 830

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BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Match: Nedd4 (gene:FBgn0259174 transcript:FBtr0299642)

HSP 1 Score: 176.792 bits (447), Expect = 3.753e-45
Identity = 130/386 (33.68%), Postives = 202/386 (52.33%), Query Frame = 2

Query: 2165 NYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNL-RSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNW-----QEHLDFF---GRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMD-RVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            N P  F     IRIRR  + ED++  I   T T+L ++ L +EF       E G+D GGL RE+   + KE  +P  GLF  S  +N         TL  +N      +EHL +F   GR+ G+ ++ G L++A F  PF+   L      ++ ID+ +++ +D + Y +L+ +K  D R+  + L F +    +G     ELKP G +I VTN NK EYI LV +++   ++ +Q S  ++G   ++P+   ++FD  E+  ++ G  + ID+ D + NT+Y G D   +  IIQ FWR +   S + +   +QFVT  SR PM GF EL     P+ F I+     +  P A TC N L LP Y+   ++++KL+ AI    GF
Sbjct:  431 NVPNKFE----IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEF-----EGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNY--------TLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMML------QKPIDLKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQN-IDVKDWRENTLYKG-DYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 789

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BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 341.273 bits (874), Expect = 1.463e-99
Identity = 217/642 (33.80%), Postives = 344/642 (53.58%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTK--DGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICT------------EKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW      KTK   G +  L+Q +  G   +++ D          F++     L+SV D +      D +  S ++ FS  EL  +   LRD   G+I L YP        +      S  + T            ++ V++F  +  +V  L  RD+R+    SG    W+          + ++ V + +  + +  +  + G ++S+         ++ S+ R + IL E+PF++P   R+K+F++L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YP+P  E L  +++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS +  VE++ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +++G    I L+DL+R T Y G     +  +I+ FW V+   S++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + + + MR KLLYAI S +GF+
Sbjct:  457 RHLWYLITSMKTKMITGSMVPLLQVMSRGSPMTLE-DSNRIIPLFYLFSSLFSHSLISVHDSEFFGSSADGQSQSSMMPFSLGELVTLSRCLRDACLGIIKLAYPETKTEHKEEYVAAFRSVGVKTNSQVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPSG---HWLSDEVNIRADKVTQLYVPSARHMWRTRRMG-RIGPLQSTLDVGLEPPPLSVSEERHLAILTELPFVVPFEERVKIFQKLIYADKREVQGEGPFLDGVN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAHVPICLEDLKRFTNYSG-GYSATHPVIKIFWDVVESFSDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGTDLERLPTASTCMNLLKLPEFCDPQLMRNKLLYAIESSAGFE 1079

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BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Match: ube3b (ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-GENE-060526-231])

HSP 1 Score: 255.373 bits (651), Expect = 7.961e-70
Identity = 146/434 (33.64%), Postives = 241/434 (55.53%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  N  +YP+P   +   +N  +  +F G+MLG  +++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ + VTN NKI YI+L+A ++++ QI +QT+  I G   ++  E   +F   E+  +I+G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  637 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPT--SSIHENHLQLFEFVGKMLGKAMYEGIVVDVPFASFFLSQVLGHHHSTFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYG-GFHSSHRVILWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 1067

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BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 237.654 bits (605), Expect = 2.729e-64
Identity = 157/510 (30.78%), Postives = 264/510 (51.76%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTK--DGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICT------------EKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEI 2911
            R LW      KTK   G +  L+Q +  G   +++ D          F++     L+SV D +      D +  S ++ FS  EL  +   LRD   G+I L YP        +      S  + T            ++ V++F  +  +V  L  RD+R+    SG    W+          + ++ V + +  + +  +  + G ++S+         ++ S+ R + IL E+PF++P   R+K+F++L+      +     F     + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YP+P  E L  +++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS +  VE++ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI
Sbjct:  457 RHLWYLITSMKTKMITGSMVPLLQVMSRGSPMTLE-DSNRIIPLFYLFSSLFSHSLISVHDSEFFGSSADGQSQSSMMPFSLGELVTLSRCLRDACLGIIKLAYPETKTEHKEEYVAAFRSVGVKTNSQVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPSG---HWLSDEVNIRADKVTQLYVPSARHMWRTRRMG-RIGPLQSTLDVGLEPPPLSVSEERHLAILTELPFVVPFEERVKIFQKLIYADKREVQGEGPFLDGVNVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEI 958

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Match: itcha (itchy E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-120919-4])

HSP 1 Score: 192.586 bits (488), Expect = 5.418e-50
Identity = 126/367 (34.33%), Postives = 198/367 (53.95%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L I F       E G+D GG+ RE+   +  E  +P   LF      N  +  NP   ++ PD+ + +  F GR + + +F G  ++  F+  F +++ N       + + +L+ +D + Y +L+ +K  + +EE  L+  F+V +   G   T ELKP+G +I VT  NK EYI LVA+++L+R + +QT   + G NDV+P +  Q FD  E+  ++ G    IDL D QRN+IY       SS+ I  FW+ + EM  +++   +QFVT   R P+ GF++L       KF I+ V   + LP + TC N L LP Y++ E+++EKLL+AI    GF
Sbjct:  498 IHVSRKTLFEDSFQQIMGCHPQDLRRRLWIIFP-----GEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINP-ASSINPDHLK-YFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKP-----LALKDLESIDPEFYNSLIWIKD-NNIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEGFNDVLPQQYLQYFDAKELEVMLCGMQE-IDLGDWQRNSIYRHYA--RSSKQIVWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 848

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BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Match: wwp1 (WW domain containing E3 ubiquitin protein ligase 1 [Source:ZFIN;Acc:ZDB-GENE-131120-84])

HSP 1 Score: 180.259 bits (456), Expect = 2.575e-47
Identity = 120/370 (32.43%), Postives = 198/370 (53.51%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L + F       E G+D GGL RE+   +  E  +P   LF      N  +  NP   T+ PD    HL +F   GR + + +F G  ++  F+  F +++ +     +++ + +L+ +D + Y +L+ ++  + +EE  L+  F+V     G   + +LK +G ++ VT  NK EYI L+A+++ +R +  QT   ++G N+VVP++  Q FD  E+  ++ G    +DL D QRNT+Y      +S +II  FW+++ E+  + +   +QFVT   R P+ GF+EL       KF I+ V     LP + TC N L LP Y++ E+++EKLL+AI    GF
Sbjct:  230 ITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIF-----RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINP-ASTINPD----HLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS-----KKLILKDLESIDPEFYNSLIWIRD-NNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQE-VDLQDWQRNTVYRHYTR-NSKQIIW-FWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGF 580

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Match: rpa1 (replication protein A1 [Source:Xenbase;Acc:XB-GENE-945047])

HSP 1 Score: 336.265 bits (861), Expect = 1.195e-97
Identity = 215/631 (34.07%), Postives = 343/631 (54.36%), Query Frame = 2

Query: 1493 RRLW---GSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI----KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLIN-------QSKYNQPNTVANSH---QICTE--KLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL---EWVKP-GLCRINVENFKRYFESLYINYKFGTIRS--------SQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW    S   +      + L+Q +  G   S++ D          F++     L+SV D +      ++  +  S ++ F+ D+L  +   LRD   G+I L YP           + +       N+    QI  E  + +++F  +  +V  L +RD R+        L   E +K   + ++ V + +  +    +  + G ++S        + ++ S+ RQ+ IL E+PF++P   R+K+F+ L+      +     F     + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  E+  +I+G    I LDDL+  T Y G    D + +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   M+ KLLYAI   +GF+
Sbjct:  451 RHLWYLISSMTTKMITGSRVPLLQVISRGSPMSLE-DSNRIIPLFYLFSSLFSHSLISVHDNEFFGDPREVAGQRQSSMMPFTLDQLIVLSRCLRDACLGIIKLAYPETKPEVREEYMAAFRSIGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQENIKADKVTQLYVPSARHVWRVRRMG-RIGPLQSTLDVGLEPAPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNTHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQELQVLISGAQVPICLDDLKSFTNYSGGYSADHA-VIKIFWRVVENFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYAIECAAGFE 1075

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Match: rpa1 (replication protein A1 [Source:Xenbase;Acc:XB-GENE-945047])

HSP 1 Score: 336.265 bits (861), Expect = 1.513e-97
Identity = 215/631 (34.07%), Postives = 343/631 (54.36%), Query Frame = 2

Query: 1493 RRLW---GSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI----KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLIN-------QSKYNQPNTVANSH---QICTE--KLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL---EWVKP-GLCRINVENFKRYFESLYINYKFGTIRS--------SQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW    S   +      + L+Q +  G   S++ D          F++     L+SV D +      ++  +  S ++ F+ D+L  +   LRD   G+I L YP           + +       N+    QI  E  + +++F  +  +V  L +RD R+        L   E +K   + ++ V + +  +    +  + G ++S        + ++ S+ RQ+ IL E+PF++P   R+K+F+ L+      +     F     + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  E+  +I+G    I LDDL+  T Y G    D + +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   M+ KLLYAI   +GF+
Sbjct:  456 RHLWYLISSMTTKMITGSRVPLLQVISRGSPMSLE-DSNRIIPLFYLFSSLFSHSLISVHDNEFFGDPREVAGQRQSSMMPFTLDQLIVLSRCLRDACLGIIKLAYPETKPEVREEYMAAFRSIGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQENIKADKVTQLYVPSARHVWRVRRMG-RIGPLQSTLDVGLEPAPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNTHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQELQVLISGAQVPICLDDLKSFTNYSGGYSADHA-VIKIFWRVVENFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYAIECAAGFE 1080

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Match: rpa1 (replication protein A1 [Source:Xenbase;Acc:XB-GENE-945047])

HSP 1 Score: 310.457 bits (794), Expect = 1.789e-88
Identity = 201/581 (34.60%), Postives = 318/581 (54.73%), Query Frame = 2

Query: 1625 FANCLHWRLLSVQDLDLI----KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLIN-------QSKYNQPNTVANSH---QICTE--KLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL---EWVKP-GLCRINVENFKRYFESLYINYKFGTIRSS---QVTSSDWRQIVILKEMPFIIPI--GTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            F++     L+SV D +      ++  +  S ++ F+ D+L  +   LRD   G+I L YP           + +       N+    QI  E  + +++F  +  +V  L +RD R+        L   E +K   + ++ V + +  +    +  + G ++S+   ++  S       L    FI  I    R+ +F+ L+      +     F     + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  E+  +I+G    I LDDL+  T Y G    D + +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   M+ KLLYAI   +GF+
Sbjct:  502 FSSLFSHSLISVHDNEFFGDPREVAGQRQSSMMPFTLDQLIVLSRCLRDACLGIIKLAYPETKPEVREEYMAAFRSIGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQENIKADKVTQLYVPSARHVWRVRRMG-RIGPLQSTLDGKICFSCTVYFTCLANNSFICAIVWEERINIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNTHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQELQVLISGAQVPICLDDLKSFTNYSGGYSADHA-VIKIFWRVVENFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYAIECAAGFE 1077

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Match: rpa1 (replication protein A1 [Source:Xenbase;Acc:XB-GENE-945047])

HSP 1 Score: 268.085 bits (684), Expect = 5.133e-74
Identity = 188/581 (32.36%), Postives = 297/581 (51.12%), Query Frame = 2

Query: 1625 FANCLHWRLLSVQDLDLI----KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLIN-------QSKYNQPNTVANSH---QICTE--KLVKMFIELQRVVIRLYNRDVRKGLKMSGKRL---EWVKP-GLCRINVENFKRYFESLYINYKFGTIRSS---QVTSSDWRQIVILKEMPFIIPI--GTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            F++     L+SV D +      ++  +  S ++ F+ D+L  +   LRD   G+I L YP           + +       N+    QI  E  + +++F  +  +V  L +RD R+        L   E +K   + ++ V + +  +    +  + G ++S+   ++  S       L    FI  I    R+ +F+ L+      +     F     + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LN+QI                  CF  + L        GG S                       +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   M+ KLLYAI   +GF+
Sbjct:  502 FSSLFSHSLISVHDNEFFGDPREVAGQRQSSMMPFTLDQLIVLSRCLRDACLGIIKLAYPETKPEVREEYMAAFRSIGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQENIKADKVTQLYVPSARHVWRVRRMG-RIGPLQSTLDGKICFSCTVYFTCLANNSFICAIVWEERINIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNTHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQA--------CFCGYTL--------GGYS-------------------ADHAVIKIFWRVVENFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYAIECAAGFE 1043

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 256.144 bits (653), Expect = 5.890e-70
Identity = 148/434 (34.10%), Postives = 242/434 (55.76%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKN-NLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   T+   +  I IRR  + ED + Q+++ +   ++  ++++F++  G++E G+D  G+ +EFL  IIK   DP   LF +T + + +YP+P   +   +N+ +  +F G+MLG  +++G++V+  FA FF+ +L  +  S     +D L  LD + Y+NL S+K  D  + ++ L  +      G     EL P G+ I VTN NKI YI+L+A ++++ QI  QT   I+G   ++  E  ++F   E+  +I+G ++ IDLDDL+++T+Y+G     S  +I   W +L  + S +EK  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +REKL YAI  ++GF+
Sbjct:  620 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETNTASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPT--SYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYG-GFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFE 1050

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BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Match: Ube3c (ubiquitin protein ligase E3C [Source:MGI Symbol;Acc:MGI:2140998])

HSP 1 Score: 336.65 bits (862), Expect = 7.836e-98
Identity = 219/645 (33.95%), Postives = 336/645 (52.09%), Query Frame = 2

Query: 1493 RRLW---GSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQD----LDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQ-------SKYNQPNTVANSH-QICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFK------------RYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW    S   Q      + L+Q +  G   S + D          F++     L+S+ D     D I++  +  S ++ F+ +EL  +   LRD   G+I L YP           + +       NS  Q C +   K +++L +V+  L      K LK    R  +  P       E+ K            R+        + G ++S+         ++ S+ RQ+ IL E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS +  VEE+ L+FTV  +  G +Q VELK  G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +I+G    + L+DL+  T Y G    D   +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   +R KLLYAI   +GF+
Sbjct:  457 RHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFE-DSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLV-----KMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSA---DVDIHHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHP-VIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFE 1081

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BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Match: Ube3b (ubiquitin protein ligase E3B [Source:MGI Symbol;Acc:MGI:1891295])

HSP 1 Score: 252.677 bits (644), Expect = 6.980e-69
Identity = 141/434 (32.49%), Postives = 243/434 (55.99%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P ++P   R+ LF       KE LG +   ++   +  I IRR  + ED + Q+++ +   ++  ++++F++  G++E G+D  G+ +EFL  IIK   DP   LF +T  +  +YP+P   +   +N+ +  +F G+MLG  +++G++V+  FA FF+ ++  +  S     +D L  LD + Y+NL S+K  D  + ++ L  +      G     EL P G+ I VT+ NKI YI+L+A ++++ QI  QT+ +I+G   ++  E  ++F   E+  +I+G ++ IDL+DL+++T+Y+G     S  +I   W +L  + + +E+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +REKL YAI  ++GF+
Sbjct:  638 RAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPT--SYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYG-GFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1068

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BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Match: Wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1914144])

HSP 1 Score: 185.652 bits (470), Expect = 2.217e-50
Identity = 125/369 (33.88%), Postives = 191/369 (51.76%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L I  I R    E G+D GG+ RE+   +  E  +P   LF  + KNN         ++ PD    HL +F   GR + + ++ G  ++  F   F +++ N   +     + +L+ +D + Y +++ +K  + +EE  L+  F       G   T ELK  GE+I VT  NK EYI L+ D++  R + +QT   ++G N+V P+E  + FD  E+  ++ G    ID+ D Q+N IY       SS+ IQ FW+V+ EM  +++   +QFVT   R P+ GF+EL       KF I  V     LP + TC N L LP Y++ E+++EKLLYAI    GF
Sbjct:   78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYI--IMR---GEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD----HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPT-----LKDLESIDPEFYNSIVWIKE-NNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQE-IDMSDWQKNAIYRHYT--KSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGF 428

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BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Match: Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like [Source:MGI Symbol;Acc:MGI:1933754])

HSP 1 Score: 182.57 bits (462), Expect = 1.928e-48
Identity = 124/386 (32.12%), Postives = 213/386 (55.18%), Query Frame = 2

Query: 2144 KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKR-KTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITG-GDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            K+L    + P  F M    ++ R+ ++E+++ +I   K    L++ L IEF      +E G+D GG+ RE+   + KE  +P  GLF   +T N  +  NP    L  ++   +  F GR+ GL +F G L++     FFI+  +     ++ I +++++ +D + Y +L  +   D  E ++L F +    +G +  V+LKPNG  I VTN NK EYI LV  ++   ++ KQ +  + G  +++PI+  ++FD +E+  ++ G GD  +D++D ++++IY     P+   +IQ FW+ +  M  +++   +QFVT  SR PM GF+EL     P+ F I+     ++LP A TC N L LP Y+  E++REKLL A+ +  GF+
Sbjct:  158 KKLKKPADIPNRFEM----KLHRNNIFEESYRRIMSVKRPDVLKARLWIEF-----ESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN-SGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG----FFIRPFYKMMLGKQ-ITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD--VDVNDWRQHSIYKNGYCPNHP-VIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 524

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Match: Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like [Source:MGI Symbol;Acc:MGI:1933754])

HSP 1 Score: 181.03 bits (458), Expect = 1.580e-46
Identity = 127/390 (32.56%), Postives = 213/390 (54.62%), Query Frame = 2

Query: 2144 KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKR-KTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITG-GDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            K+L    + P  F M    ++ R+ ++E+++ +I   K    L++ L IEF      +E G+D GG+ RE+   + KE  +P  GLF   +T N  +  NP       D    HL +F   GR+ GL +F G L++  F  PF+   L       ++I +++++ +D + Y +L  +   D  E ++L F +    +G +  V+LKPNG  I VTN NK EYI LV  ++   ++ KQ +  + G  +++PI+  ++FD +E+  ++ G GD  +D++D ++++IY     P+   +IQ FW+ +  M  +++   +QFVT  SR PM GF+EL     P+ F I+     ++LP A TC N L LP Y+  E++REKLL A+ +  GF+
Sbjct:  382 KKLKKPADIPNRFEM----KLHRNNIFEESYRRIMSVKRPDVLKARLWIEF-----ESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNED----HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML------GKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD--VDVNDWRQHSIYKNGYCPNHP-VIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 748

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BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Match: sp|Q15386|UBE3C_HUMAN (Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3)

HSP 1 Score: 337.806 bits (865), Expect = 2.038e-97
Identity = 219/640 (34.22%), Postives = 343/640 (53.59%), Query Frame = 2

Query: 1493 RRLWG--SAVEQKTKDGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQD----LDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIEL-QRVVIRLYN--RDVRKGLKMSGKRLEWVKPGLCRINVENFK------------RYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW   S++  +   G +  L+Q +  G   S + D          F++     L+S+ D     D I++  +  S ++ F+ +EL  +   LRD   G+I L YP        +  T   S  + T   ++  I++ Q+  I+L+    ++ K LK    R  +  P       E+ K            R+        + G ++S+         ++ S+ RQ+ +L E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++Y+NLL LKS  D VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LNRQI +       GL +VV +E  ++FD  EI  +I+G    I L+DL+  T Y G    D   +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   +R KLLYAI   +GF+
Sbjct:  457 RHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFE-DSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSA---DVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHP-VIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081

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BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Match: sp|Q80U95|UBE3C_MOUSE (Ubiquitin-protein ligase E3C OS=Mus musculus OX=10090 GN=Ube3c PE=1 SV=2)

HSP 1 Score: 336.65 bits (862), Expect = 5.481e-97
Identity = 219/645 (33.95%), Postives = 336/645 (52.09%), Query Frame = 2

Query: 1493 RRLW---GSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQD----LDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQ-------SKYNQPNTVANSH-QICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFK------------RYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW    S   Q      + L+Q +  G   S + D          F++     L+S+ D     D I++  +  S ++ F+ +EL  +   LRD   G+I L YP           + +       NS  Q C +   K +++L +V+  L      K LK    R  +  P       E+ K            R+        + G ++S+         ++ S+ RQ+ IL E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  + L  D++  H  F GRMLG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS +  VEE+ L+FTV  +  G +Q VELK  G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +I+G    + L+DL+  T Y G    D   +I+ FWRV+   +++EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + +   +R KLLYAI   +GF+
Sbjct:  457 RHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFE-DSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLV-----KMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSA---DVDIHHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHP-VIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFE 1081

[Close]

BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Match: sp|Q9SCQ2|UPL7_ARATH (E3 ubiquitin-protein ligase UPL7 OS=Arabidopsis thaliana OX=3702 GN=UPL7 PE=2 SV=1)

HSP 1 Score: 276.944 bits (707), Expect = 6.258e-76
Identity = 178/488 (36.48%), Postives = 265/488 (54.30%), Query Frame = 2

Query: 1889 RVVIRLYNRDVRKGLKMSGKRLEWVKPG-LCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELL----------GGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVP------------DTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R +  LY RD R     S     W+ PG   R  +    R  E L          S  +T+     ++ +   P + P   R+ +F+E +          G ++ P + ++   I +RR ++ ED F Q+     + L+S + + F++  G+ E G+D GGL +EFL +I K A   + GLF    T + L+ P+P    L  +N  + ++F GR++G  +++G+L++ SF+  FIQKL    S      ID L  LD +LYRNL+ +K  D  ++E+ LDFTV+    G    +ELKP G+  SVTN NK++YI+ +ADYKLNRQI   ++    GL D++     +LF+  E + +++GG+  ID+DDL+RNT Y G    DSS  I+ FW V+      E+   ++FVTS SRAP+LGF  L P F I  V             D +RLP+ASTC N LKLP Y+    MREKLLYAI S++GF+
Sbjct:  677 RCLHLLYERDCRHPFCASAL---WLSPGRTSRPPIAFAARTHEVLPT--------SDVLTTPSMGSVITI--TPHVFPFEERVHVFREFISKDKASRKMAGEVDAPGARSI--EIVVRRGHVVEDGFQQLN-SIGSRLKSSIHVSFVNESGLPEAGLDYGGLSKEFLTDITKAAFATEYGLFSQTPTSDRLLVPSPSARHL--ENGIQMIEFLGRIVGKALYEGILLDYSFSHVFIQKLLGRYSF-----IDELSGLDPELYRNLMYVKHYDGDLKELCLDFTVTEEFCGKMSIIELKPGGKDTSVTNENKMQYIHAMADYKLNRQIVPFSNAFYRGLTDLISPAWLKLFNAHEFNQLLSGGNHDIDVDDLRRNTKYTG-GYSDSSRTIKIFWEVMKGFEPSERCLLLKFVTSCSRAPLLGFKYLQPTFIIHKVSCDTSLWAAIGGQDVERLPSASTCYNTLKLPTYKRASTMREKLLYAITSNAGFE 1140

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BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Match: sp|O17736|ETC1_CAEEL (E3 ubiquitin-protein ligase etc-1 OS=Caenorhabditis elegans OX=6239 GN=etc-1 PE=1 SV=1)

HSP 1 Score: 273.863 bits (699), Expect = 1.558e-75
Identity = 178/592 (30.07%), Postives = 306/592 (51.69%), Query Frame = 2

Query: 1625 FANCLHWRLLSVQDLDLIKID-SEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQI------CTEKLVKMFIELQRVVIRL----------YNRDVRKGL---------KMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG---MNYPTSFAM---IPPIRIRRDYLYEDAFSQIKRK----TFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVE--EINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNT---IYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDT-DRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            F NCL+ R+ SV D D +  D   D    +EF           LRD+   LI L++P + +      N     ++        TE +  +   + +  IRL          + R+V  G+         +M   RL+ ++  +    VE     +E    +        + + +   R I ++K +PFI+P   R+KLF  LL      +Y ++F M    P + +RRD +Y DAF     K       +L+S ++++ ++  GMNE G+DGGG+ REFL  ++K A + +RG F  T++ L+YPNP    L   +   H  F GRM+G +I++  L E  FA FFI ++F    ++ ++D+ +++  D  ++++L +L+ M+  E  E+ LDF+V  S  G+ + V LKPNG    VT  N  EY+ L  +Y L ++I+     +  G+++++ IE  ++F   E+  +I G + +    +L++        G  D +  E+   FW V+ ++S D+K+  ++FVT  SRAP+ GF  + P+  + ++P + D LPT++TC+N+L++P Y N  ++ EKL YAI S +GF+
Sbjct:  424 FCNCLNKRVSSVADSDFVPTDIFVDFDHTVEF-----------LRDVSIKLIHLMFPTMARGDLYSGNLKEKMYKAETDWKDVTESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMPRRRMPNGRLQ-IERTMDTEFVERLAAIYEMDSDSENDDEDEDNNLPAVLRRAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVTVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNK-DVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELRFAAGTQDINYEEM---FWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFE 999

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BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Match: sp|Q8RWB8|UPL6_ARATH (E3 ubiquitin-protein ligase UPL6 OS=Arabidopsis thaliana OX=3702 GN=UPL6 PE=2 SV=1)

HSP 1 Score: 270.396 bits (690), Expect = 3.726e-74
Identity = 151/419 (36.04%), Postives = 241/419 (57.52%), Query Frame = 2

Query: 2054 SQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTSFAMIPP---IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDT------DRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            SQ      R   IL + PF+IP  +R+K+F   L           I      RIRRD++ EDA++Q+   +  +LRS +++ F++  G+ E G+DGGG+ ++F+  I + A D + GLF  T ++++YPNP    ++    ++HL FF   G +L   +F+G+LV+  FA FF+ KL    +      +++L  LD +LYR+L+ LK     + ++ L F +  + YG     EL P G+ + VTN N I +I+LV++++LN QI +Q+S  + G   ++P E   +F+  E+  +I+G    +D+DDL+ NT Y G        +I  FW V+   S + ++ F++FVT  SR P+LGF  L P F IQ    +      DRLPT++TC+NLLKLP YQ+ E +  KL+YAI +++GF
Sbjct:  618 SQAIMEGTRANYILMQAPFLIPFTSRVKIFTTQLATARQSHGSQGIFARNRFRIRRDHILEDAYNQMSALSEDDLRSSIRVTFVNELGVEEAGIDGGGIFKDFMEKITRAAFDVQYGLFKETADHMLYPNPGSGMIH----EQHLQFFHFLGSLLAKAMFEGILVDIPFATFFLSKLKQKYNY-----LNDLPSLDPELYRHLIFLKRYKGDISDLELYFVILNNEYGERTEEELLPGGQDMRVTNENVITFIHLVSNHRLNFQIRQQSSHFLRGFQQLIPKEWIDMFNEHELQVLISGSVDSLDIDDLRNNTNYAGGYHA-GHYVIDMFWEVMKSFSTENQKKFLKFVTGCSRGPLLGFKYLEPAFCIQRAAGSASNESVDRLPTSATCMNLLKLPPYQSKELLETKLMYAISAEAGF 1026

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BLAST of Ubiquitin protein ligase vs. TrEMBL
Match: A0A0P4W9I2 (HECT domain-containing protein OS=Scylla olivacea OX=85551 PE=4 SV=1)

HSP 1 Score: 376.326 bits (965), Expect = 5.786e-109
Identity = 223/545 (40.92%), Postives = 309/545 (56.70%), Query Frame = 2

Query: 1715 FSPDELCEIVLKLRDIMYGLILLIYP-----LINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLC-------------RINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLG------GMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKS-MDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            FS DEL ++   LRD+  GL+ L +P      I  + Y   +  A+  ++C             VV +++ RD R+    SG    W+   +              R N    + +     +           ++ +D R+  IL+E+PF+IP  +R ++F  L+G       M    +   +  + IRR +LYEDAF +I      NLR  +K+  ++  G+NE G+DGGG+ REFL  ++K A DP RG F+ T +N +YPNP    L  +N+Q H  F GRMLG  +++ LLVE   A FF+ KL   SSS  EI   +L  LD +L RNLLSLK+    V+++ LDFTV  S  G +   EL PNG +I V N N+IEYIY +ADYKLN+QI+KQ+     G+ DVVP+E  Q+FD  E+  +I+G    IDL+DL  NT Y G+   +++  IQ FW+VL E SE +KR  ++FVTS SR P+LGF EL P F IQ     DRLPTASTC+NLLKLP Y+N   +REKLLYAI S SGF+
Sbjct:  547 FSVDELVKMSASLRDVCVGLVELAHPDTRMSAITDTSYT--SMWAHCFKVCVG-----------VVRQIHLRDTRRMFCPSG---HWLSSRVTLPLNNCQTVSFIPRTNRRQRRLFMPQRLLTRNELETEGPPLSVTDERRGTILREIPFVIPFESRTQVFSRLVGIDRSISQMGAEFNERPVINVAIRRSHLYEDAFEKISPNNEPNLRLRMKVRLMNAVGLNEVGIDGGGIFREFLSELLKTAFDPTRGFFLLTLDNTLYPNPGAH-LIAENYQTHYYFIGRMLGKALYENLLVEVPLAGFFLSKLLGRSSSSAEIH--HLDSLDPELCRNLLSLKTYQGDVQDLGLDFTVLNSNLGQNTIEELIPNGTNIPVNNENRIEYIYRMADYKLNKQIAKQSQAFKKGVVDVVPLEWLQMFDWRELQMLISGASVPIDLEDLMDNTRYGGIYSTENT-TIQAFWQVLREFSETQKRQLLKFVTSCSRPPLLGFKELQPPFCIQPSGSEDRLPTASTCMNLLKLPEYKNEHTLREKLLYAITSGSGFE 1071

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BLAST of Ubiquitin protein ligase vs. TrEMBL
Match: T2MCI0 (Ubiquitin-protein ligase E3C (Fragment) OS=Hydra vulgaris OX=6087 GN=UBE3C PE=2 SV=1)

HSP 1 Score: 357.066 bits (915), Expect = 5.417e-106
Identity = 202/534 (37.83%), Postives = 322/534 (60.30%), Query Frame = 2

Query: 1706 VIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTS--FAMIPP-----IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHG---VDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            ++ FS  E+ E+   +RD + GLI+L+YP   +SK  +    +     C  ++   FI+       LY RD R           W+      I+ EN      S         +    ++  + R + +LK +PF +P   R+++F+ +L      +   F  + P     I + R YLY+DA+ Q+ +    +++  ++I  I+  G++E G+DGGG+ REF+  +++   DP  G F +T   L+YPNP++  +YPD + +HL F GRMLG +I++ ++VE   A FF+ KL N   S  ++DI +L+ LD +LY+NLL LK+  + VEE++L FTV+ + YG ++ +ELKP G+ ISVTNSNKIEYI+L+ADY+LN+QI    +   +GL+DV+ IE  Q+FD  E+  +I+G    ID++DL+RNT Y G    +DP     I+ FW++L  +S+ +KR F++FVTS SR P+LGFSEL P+F +    + DRLPTASTC+N LKLP Y++++ ++ +L+YAI +++GF+
Sbjct:  142 LMPFSLAEVVEMSTIVRDSILGLIMLMYP---ESKTVETKFYSKCVFCC--QMATAFIK------HLYARDCRHQF---CPEKHWLS-DRAAISQENLN--VSSFLEEQTAEEVSKPGLSLLNLRNLAVLKYIPFAVPFLQRVRIFQRILSEDKKESQNIFQNVLPSHSINITVNRKYLYQDAYDQLSQDRADDIKKVIRIHMINAQGLDEAGIDGGGVFREFMSQLLRSGFDPSIGFFKTTSQQLLYPNPDISLIYPD-YLKHLHFLGRMLGKVIYESMMVELPLADFFLCKLLNKGGS--DVDIHHLESLDPELYKNLLYLKNYKEDVEELSLSFTVANNEYGETKVLELKPGGKDISVTNSNKIEYIHLMADYRLNKQIRSHCNAFRSGLSDVINIEWLQMFDQRELQILISGAQIPIDIEDLRRNTSYSGSFTAEDP----YIEEFWKILEGLSDHQKRLFLKFVTSCSRPPLLGFSELYPRFCVHGGGEEDRLPTASTCMNFLKLPVYKSIDLLKTRLIYAIEAEAGFE 651

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BLAST of Ubiquitin protein ligase vs. TrEMBL
Match: A0A1A8K3S8 (Ubiquitin protein ligase E3C (Fragment) OS=Nothobranchius kuhntae OX=321403 GN=UBE3C PE=4 SV=1)

HSP 1 Score: 354.369 bits (908), Expect = 7.333e-104
Identity = 223/636 (35.06%), Postives = 346/636 (54.40%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTK--DGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQ-------SKYNQPNTVANSH-QICTEKLVKMFIELQRVVIRLYN----RDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKELL--------GGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW      KTK   G +  L+Q +  G   S + D          F++     L+SV D +    ++D +  S ++ F+  EL  +   LRD   G+I L YP           + +       N+  Q C     K +++L +V+  L      RD+R+    +G    W+          + ++ V + +  + +  +  + G ++S+        Q++ S+ R + IL E+PF++P   R+K+F+ L+        G   +P        + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  E L  D++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS +  VEE+ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +I+G    I LDDL+  T Y G    +   +IQTFW V+   +++EKR  ++FVTS SR P+LGF EL P F I     D DRLPTASTC+NLLKLP + + + MR KLLYAI S +GF+
Sbjct:  131 RHLWHLITSMKTKMITGSMVPLLQLISRGSPMSFE-DSNRIIPLFYLFSSLFSHSLISVHDSEFFGHEMDGQIQSSMMPFTLLELVTLSRCLRDACLGIIKLAYPETKAEHREEYMAAFRSVGVKTNAEVQHCIHAEQKRWVQLFKVITNLVKMVKARDIRRPFCPAG---HWLSEEVNIRADKVTQLYVPSARHVWRTRRMG-RIGPLQSTLDVGLEPLQLSVSEERHLAILTELPFVVPFEERVKIFQRLIYVDKYDVQGDGPFPDGIN----VTIRRNYIYEDAYDKLSPENEPDLKKKIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAEMLVGDSFTRHYYFLGRILGKALYENMLVEMPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEGDVEELGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAHVPICLDDLKNFTNYSGGYSANHP-VIQTFWEVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGTDLDRLPTASTCMNLLKLPEFCDQQLMRNKLLYAIESSAGFE 753

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BLAST of Ubiquitin protein ligase vs. TrEMBL
Match: A0A0R3X0Q3 (HECT domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS6715 PE=4 SV=1)

HSP 1 Score: 364.77 bits (935), Expect = 8.845e-104
Identity = 229/690 (33.19%), Postives = 356/690 (51.59%), Query Frame = 2

Query: 1499 LWGSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLIKIDSEDSS-KVIEFSPDELCEIVLKLRDIMYGLILLIYPL-------------------------INQSKYNQPNTVANSH------------------QICTEKLVKMFIELQRVVIRLYNRDVRK--------GLKMSG--KRLEWVKPGLC-----------------RINVENFKR----YFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGM----------NYPTSFAMIPPI--RIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRN---------LLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHG-VDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            LW +A++  T DG   L   +  G +  I   M +F G LL F N L+ RL+ + D ++    ++ S   +  F P EL  + L+LRD+M GLI L+YPL                         + +     P+   +S                   + C  +   +F+  Q+VV ++Y    R+         L+ +G  +  EW++P +                   +  +N  R    YF  L  N     +  + +T  DWR++  + E+PFI P   R+KLF  ++             NY +       I  +IRRD++YEDAF+ +     ++      + F +  G  E G+DGGGL RE L  +I++  DP RGLF+   ++ +YPNP+   L  D+ + H  F G +L   I++G++V+  FAPFF+ K+ + S S   +D ++L+ LD +LYR+         L  LKS +  V ++ LDFT+ +  YG +  VELKP G  I VTN++++EYI LVA+YKLN+QI  Q+   ++G++ V+ I+  QLFD DE+  +I G  + ID+DD  +NT + G + D  +   I  FW  + ++ ED+KRN I+FVT+ SR PM GF  L P F IQ++ DT   PT+STC+NLLKLP YQ  +E++EK LY I S++GF+
Sbjct:  509 LWATAIKMPTDDGKYKLFDIVASGIMPEIPKTMDKFTGVLLTFLNSLNHRLIFLTDAEVSAEPTDISGLNIYGFDPSELLVVGLRLRDLMLGLIDLLYPLRPPARARPGGIYVPVTLREVIERVELQRMSEKGPSASGSSTTAAISASGELTDDEEERLRWCLHRWRTLFLAAQKVVAQIYGWHRRQQHQEDWALSLETAGNVESSEWLRPEVVPDFNNKRTATWMVERYLELRDKNLTRAQLGYFSCLNTNRTEHKL--TAMTCMDWRKMTTILEVPFIFPFWDRVKLFVSMVRHFRLSIQGTPEFNYMSGGGRTRTINMQIRRDHVYEDAFTSLFGSQVSSFHPRFMVTFYNEAGTMEMGIDGGGLCREMLLEVIRQGFDPSRGLFLYNDDHALYPNPDAGALMEDH-EAHYAFLGAILSKAIYEGMVVDLQFAPFFLAKIVSPSKSLS-VDFNHLRSLDRELYRHVIELLPFLQLCRLKSYEGDVRDLELDFTIVQHIYGKNTVVELKPGGASIPVTNASRVEYINLVANYKLNKQILHQSMSFLSGMSSVIDIKWLQLFDADELQIVIAGTPTDIDVDDWMQNTQFVGDMTDEQNQRTINLFWAFVRDLGEDQKRNLIRFVTASSRPPMFGFGFLYPPFTIQLISDTSHYPTSSTCMNLLKLPTYQTEDELKEKFLYVIQSNAGFE 1194

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BLAST of Ubiquitin protein ligase vs. TrEMBL
Match: V4B5L0 (HECT domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_111732 PE=4 SV=1)

HSP 1 Score: 361.303 bits (926), Expect = 2.162e-103
Identity = 228/634 (35.96%), Postives = 352/634 (55.52%), Query Frame = 2

Query: 1499 LWG--SAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDL-----IKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQS---KYNQP--NTVAN--SHQICTEKLVKMFIELQRVVI----RLYNRDVRKGLKMSGKRLEWVK---------------PGLCRINVENFKRYFESLYINYKFGTI-RSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG-----MNYPTSFAMIPPIRI--RRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIV-PDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            +W    A+  +T  G  T + S++   +   ++D +     L  F       L+++ D +       K++S+ ++  + FS  EL  +   LRD   G++ L +P I  S   +Y     +T  N  S Q   ++  K +I L +VV+    +LYNRD R+       +  W+                P + ++ V  F   F  L +N  F     S  + + D R +++L E+PF+I    R K+ + L+        +  T+F + P I I  RRDY+YEDAF ++  +   NL+  ++++  +  G++E G+DGGG+ REFL +++K A DP RG F  T + LIYPNP    L  DN+ +H  F GRMLG  I++ +LVE  FA FF+ K+   SS    +DI  LQ LD  +YRNLLSLK+   V E+ LDF+V  + +G ++ +ELKP G +I VTN NKIEY++L+ADYK+NRQI    +    G+ DV+ +E  Q+FD  E   +I+G  + I++DDL+ NT Y G    ++  +I+ FW+V+   ++ +K   ++FVTS S+ P+LGF +L P F I     D DRLPTASTC+NLLKLP + +   +R KLLYAI S++GF+
Sbjct:  455 IWNICKALSTETCTGSTTSLLSMLGKGLPMYESDKQRIICILYVFCAMFSHSLITLHDAEFYGEERCKLNSQYAA--MPFSLSELVPMSYYLRDACLGILDLAHPDIKHSINDEYQHALVHTFNNRKSDQDIQDEEKKTWICLFKVVVVLVRQLYNRDTRRRF---CPKTHWLSSHVTVQANRVSISLLPSVKQVIVSQF---FFKLSLNTTFTLYDESPPLANRDVRNLIVLTEIPFVISFAERFKILQRLIMANKEENQSEMTNFLVGPSINIAIRRDYVYEDAFDKLSPENEANLKLKMRVQLRNAAGLDEAGIDGGGVFREFLTHLLKTAFDPNRGFFQYTTDRLIYPNPHASQL-EDNYIKHYYFIGRMLGKAIYENMLVELPFASFFLAKIL--SSHGFNLDIHYLQSLDPVMYRNLLSLKNEIDVSELGLDFSVIDNSFGENKIIELKPGGRNIPVTNENKIEYVHLMADYKVNRQIHSHCAAFRQGMADVISLEWLQMFDHHEFQILISGTSTPINIDDLRHNTSYSG-GFSETHPVIELFWKVVASFTDQQKSQLLKFVTSCSQQPLLGFKDLYPPFCIHDAGTDLDRLPTASTCMNLLKLPHFTDESLLRNKLLYAIESNAGFE 1076

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BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:103025647])

HSP 1 Score: 340.117 bits (871), Expect = 1.634e-99
Identity = 216/642 (33.64%), Postives = 341/642 (53.12%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTK--DGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICT------------EKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVP-DTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW      +TK   G L  L+Q +  G   S + D          F++     L+S+ D +     +D +    ++ FS  EL  +   LRD   G+I L YP        +      S  + T            ++ V++F  +  +V  L  RD+R+     G    W+          + ++ V + +  + S  +  + G ++S+         ++ S+ R + IL E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L++P+P  E L  +++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL +KS +  VE++ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +I+G    I LDDL++ T Y G     +  +I+ FW V+   S+DEKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + + + M+ KLLYAI S SGF+
Sbjct:  408 RHLWHLITSMRTKMITGSLVPLLQLMSRGSPMSAE-DSSRIIPLFYLFSSLFSHSLISIHDTEFFGDSLDGQGQPSMMPFSLSELVTLSRCLRDACLGIIKLAYPETKSEHREEYAAAFRSVGVKTNSQVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPGG---HWLSEEVNIRADKVTQLYVPSARHVWRSRRMG-RIGPLQSTLDVGLEPPPLSVSEERHLAILTELPFVVPFEERVKIFQRLIYADKRDVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLSELLKSGFNPNQGFFRTTNEGLLFPSPTAEMLIGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFMKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAHVPICLDDLKKFTNYSG-GYSATHPVIKIFWDVVENFSDDEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGNDLERLPTASTCMNLLKLPEFCDEQLMKSKLLYAIESSSGFE 1030

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BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:103025647])

HSP 1 Score: 340.117 bits (871), Expect = 3.088e-99
Identity = 216/642 (33.64%), Postives = 341/642 (53.12%), Query Frame = 2

Query: 1493 RRLWGSAVEQKTK--DGDLT-LMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICT------------EKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKEL--------------LGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVP-DTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R LW      +TK   G L  L+Q +  G   S + D          F++     L+S+ D +     +D +    ++ FS  EL  +   LRD   G+I L YP        +      S  + T            ++ V++F  +  +V  L  RD+R+     G    W+          + ++ V + +  + S  +  + G ++S+         ++ S+ R + IL E+PF++P   R+K+F+ L              L G+N          + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L++P+P  E L  +++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL +KS +  VE++ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+QI         GL +VV +E  ++FD  EI  +I+G    I LDDL++ T Y G     +  +I+ FW V+   S+DEKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + + + M+ KLLYAI S SGF+
Sbjct:  457 RHLWHLITSMRTKMITGSLVPLLQLMSRGSPMSAE-DSSRIIPLFYLFSSLFSHSLISIHDTEFFGDSLDGQGQPSMMPFSLSELVTLSRCLRDACLGIIKLAYPETKSEHREEYAAAFRSVGVKTNSQVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPGG---HWLSEEVNIRADKVTQLYVPSARHVWRSRRMG-RIGPLQSTLDVGLEPPPLSVSEERHLAILTELPFVVPFEERVKIFQRLIYADKRDVQGDGPFLDGIN----------VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLSELLKSGFNPNQGFFRTTNEGLLFPSPTAEMLIGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFMKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAHVPICLDDLKKFTNYSG-GYSATHPVIKIFWDVVENFSDDEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGNDLERLPTASTCMNLLKLPEFCDEQLMKSKLLYAIESSSGFE 1079

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BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:111196222])

HSP 1 Score: 253.832 bits (647), Expect = 7.511e-70
Identity = 146/434 (33.64%), Postives = 240/434 (55.30%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  N  +YP+P   +   +N  +  +F G+MLG  +++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ + VTN NKI YI+L+A ++++ QI +QT   I G   ++  E   +F   E+  +I+G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  532 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPT--SNIHENHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYG-GFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 962

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BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:111196222])

HSP 1 Score: 254.603 bits (649), Expect = 1.480e-69
Identity = 146/434 (33.64%), Postives = 240/434 (55.30%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  N  +YP+P   +   +N  +  +F G+MLG  +++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ + VTN NKI YI+L+A ++++ QI +QT   I G   ++  E   +F   E+  +I+G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  637 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPT--SNIHENHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYG-GFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 1067

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Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  N  +YP+P   +   +N  +  +F G+MLG  +++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ + VTN NKI YI+L+A ++++ QI +QT   I G   ++  E   +F   E+  +I+G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + DE+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  637 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPT--SNIHENHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYG-GFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 1067

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BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 334.724 bits (857), Expect = 6.925e-98
Identity = 207/574 (36.06%), Postives = 314/574 (54.70%), Query Frame = 2

Query: 1649 LLSVQDLDLI--KIDSEDSSKVI--EFSPDELCEIVLKLRDIMYGLILLIYPL----INQSKYNQPNTVANS----HQICTEK--LVKMFIELQRVVIRLYNRDVRKGLKMSGKRL------------EWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKS-MDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            L+SV D +    +  S  S+  +   FS DEL  +   LRD   G+I L YP     + +S      +V +S    H++  ++    ++F  +  +V  L  RD R+    S   L            +  +P    +      R    LY +   G      ++ S+ RQ+ IL E+PF++P   R+K+F+ L+          + F +   + IRR Y+YEDA+ ++  +   +LR  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNPE   L  D +  H  F GRMLG  +++ +LVE  FA FF+ KL   +    ++DI +L  LD ++YRNLL LKS    VEE+ L+FTV  +  G +Q VELK  G+ I VT++N+I YI+LVADY+LNRQI +       GL  V+ +E  ++FD  E+  +++G    IDL DL+  T Y G    D   +I+ FW V+   ++++KR  ++FVTS SR P+LGF EL P F +     D +RLPTASTC+NLLKLP +   E M  KLLYAI S +GF+
Sbjct:  521 LVSVHDSEFFGDRPPSAGSAAGVGMPFSLDELVAMSACLRDACLGMIHLAYPESRPELRESYAVALQSVGSSMPAEHRLQEQRQRYTQLFKVISNLVKMLKARDTRRPFCPSNHWLSPEVSIRADRVPQLYRPAARHVWRNRRIRGIGPLYSSLDVGD-EGPPLSVSEERQLAILTELPFVVPFQERVKIFQRLISSDKEESQGDSPFFVGINVTIRRPYIYEDAYDKLSPENEPDLRRRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKTGFNPHQGFFRTTNQGLLYPNPEARLLVGDGFTRHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTTG---DVDIHHLASLDPEVYRNLLFLKSYQGDVEELGLNFTVVNNELGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLATVINLEWLRMFDEQELQVLLSGAQVPIDLQDLKNFTNYSGGYTADHP-VIKVFWHVVEGFTDEQKRKLLKFVTSCSRPPLLGFKELFPAFCVHNGGADPERLPTASTCMNLLKLPEFLEEETMHGKLLYAIESAAGFE 1089

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BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Match: ube3b (ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-GENE-060526-231])

HSP 1 Score: 247.284 bits (630), Expect = 6.591e-68
Identity = 155/513 (30.21%), Postives = 259/513 (50.49%), Query Frame = 2

Query: 1868 KMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----------------MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            ++F  +   ++ LY RD R+          W+K               + L  N  F     S++     R  ++L+ +P ++P   R+ LF+ ++                  +N+    A I  I +RR  + ED + Q+ R    +L+  ++++FI+  GM+E G+D  G+ +EFL  IIK+  DP+  LF ++  +  +YP+P   +   +N  + ++F G+MLG  +++G++V+  FAPFF+ ++    +S     ID L  LD + Y+NL S+K  D  V E+ L F+      G     EL P G+   VTN NKI YI+++A +++  +I KQT   I+G   ++  E   +F   E+  +I G    ID +DL+++T+Y+G    ++  +I   W +L  E +  E+  F++FVTS SR P+LGF+ L P F+I+ V   D                         RLPT+STC NLLKLP Y     +R+KL YA+  ++GF+
Sbjct:  595 QLFASVHSWLMTLYERDCRRRFAPED---HWLK---------------KDLKANVLF-----SELEKGKKRAKLLLQHIPHVLPHKDRVVLFRSMVAKEKSSLVTGNQIVSLMDLNHG---APITHITVRRSRMLEDGYEQLSRLPPNSLKGTIRVKFINDLGMDEAGIDQDGVFKEFLEEIIKKVFDPELNLFKITIGDERLYPSPT--SYVHENHLQLMEFVGKMLGKAVYEGIVVDVPFAPFFLSQVRGVHTSMPYSSIDELPSLDAEFYKNLTSIKRYDGDVSELGLTFSYEEDIMGKLVCYELCPGGKTTLVTNENKISYIHMLAHHRMYVKIKKQTGAFIHGFKSLISPEWMGMFSTPEMQRLIAGDTGEIDFEDLRKHTVYYG-GFHNNHRVIIWLWDILTKEFTAQERAMFLKFVTSCSRPPLLGFAHLKPSFSIRCVEVADDQDTGDTLGSVLRGFFTIRKKEPAGRLPTSSTCFNLLKLPNYSKKSVLRDKLRYAVSMNTGFE 1078

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BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 178.333 bits (451), Expect = 4.881e-48
Identity = 126/393 (32.06%), Postives = 216/393 (54.96%), Query Frame = 2

Query: 2144 KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQI---KRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASF-APFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGV-SQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITG-GDSLIDLDDLQRNTIY---HGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL----SPK-FAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            K+L    + P  F M    ++ R  + ED++ +I   KR     L++ L IEF       E G+D GG+ RE+   I KE  +P  GLF   +T N  +  NP +  L  +    +  F GR+ G+ +F G L++  F  PF+   L      ++ I +++++ +D + Y +L+ +   D  + ++L F +    +G  +  VELKPNG  I VTN NK EYI LV  ++   ++ KQ +  + G ++++P++  ++FD +E+  ++ G GD  +D++D +++TIY   +  + P    +IQ FW+ +  M  +++   +QFVT  SR PM GF+EL     P+ F I++   +++LP A TC N L LP Y++ +++REKL  AI +  GF+
Sbjct:  124 KKLKKPADIPNRFEM----KLHRASILEDSYRRIVAVKRADL--LKARLWIEFD-----GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINP-ISGLCNEEHLSYFTFIGRVAGMAVFHGKLLDGFFIRPFYKMML------QKPITLNDMESVDSEYYNSLMWILENDPAD-LDLRFCIDEEMFGQQTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCGLGD--VDVNDWRQHTIYKNSYCANHP----VIQWFWKAVLLMDGEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEMWSTSEKLPRAHTCFNRLDLPPYESFDDLREKLNIAIENAQGFE 491

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BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Match: wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-000607-82])

HSP 1 Score: 161.77 bits (408), Expect = 1.004e-40
Identity = 106/320 (33.12%), Postives = 174/320 (54.37%), Query Frame = 2

Query: 2345 REFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            RE+   +  E  +P   LF  + KNN         ++ PD    HL +F   GR + + ++ G  ++  F+  F +++ N     +++ I +L+ +D + Y +L+ L+  + +EE  L+  F+V     G   + +LKP+G  I VT  NK EYI L+ +++ +R + +QT   ++G ++VVP++    FD  E+  ++ G    IDL D QR+TIY   +   SS+ I  FW+V+ EM  +++   +QFVT   R P+ GF+EL       KF I+ V     LP + TC N L LP Y++ E+++EKLLYAI    GF
Sbjct:  623 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD----HLAYFRFIGRFIAMALYHGKFIDTGFSLPFYKRMLN-----KKLTIKDLESIDPEFYNSLIWLRD-NNIEECGLEMFFSVDMELLGKVSSHDLKPDGSDILVTEENKEEYIGLMTEWRFSRGVEEQTKAFLDGFSEVVPLQWLLYFDERELEVMLCGMQE-IDLADWQRSTIYRHYN--RSSKQISWFWQVVKEMDNEKRLRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGF 929

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BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Match: ube3a (ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-GENE-041114-190])

HSP 1 Score: 155.992 bits (393), Expect = 5.222e-39
Identity = 122/392 (31.12%), Postives = 196/392 (50.00%), Query Frame = 2

Query: 2129 RMKLFKELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTN---LRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFV-STKNNLIYPNPE-LETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRV--EEINLDFTVSR-SCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVV---PIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            R+ +   L+ G + P        +++RRD++ +DA  +++     N   L+  L +EF       E GVD GG+ +EF + +++E  +P  G+F       L + NP  LE       +      G +LGL I+   +++  F     +KL     +       +L      LY++L  L + +    ++I   F +S    +G   T +LK NGE I VTN NK E++ L A+Y LN+ + KQ      G + V    P++   LF  +E+  ++ G   ++D   L+  T Y G  +  SS +I+ FW  + +  ED+KR F+QF T   RAP+ G  +L    A +  PD+DRLPTA TC N+L LP Y + E+++E+LL AI    GF
Sbjct:  499 RITVLHSLVQGQHLPYL-----RLKVRRDHVIDDALVRLEMIAMENPADLKKQLYVEF-----EGEQGVDEGGVSKEFFQLVVEELFNPDIGMFTFDESTRLFWFNPSSLEN------EGQFTLIGIVLGLAIYNNCILDIHFPMVVYRKLMGKRGT-----FHDLADSHPALYQSLKDLLAYEGSVEDDIMATFRISYFDMFGTPITQDLKENGEDIPVTNDNKKEFVDLYAEYILNQSVEKQFKAFRRGFHMVTSESPLKA--LFRPEEVELLVCGS-RVLDFHALEDATEYDGGFN-KSSRVIRDFWDTVHDFCEDKKRLFLQFTTGTDRAPVGGLGKLKMIIA-KNGPDSDRLPTAHTCFNVLLLPEYSSREKLKERLLKAITHAKGF 864

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BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 225.328 bits (573), Expect = 1.961e-61
Identity = 153/424 (36.08%), Postives = 229/424 (54.01%), Query Frame = 2

Query: 2063 TSSDWRQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIR----------IRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEAC-DPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM--DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIV-PDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            +S  +R++ IL E+PF IP   R+ LF       K+ L   +      M  P            I RD + EDAF+          ++ L + FI+ FG  E G+DGGG+ +EFL  +  E   DPK  LF +     +YP+     +Y     +++ F G+++G  +++ +L++ SFA FF++KL N S+        +L   D  LY NL+ L +M  D ++ ++L F +       ++ V+L PNG    VT  N + Y+  V DYKLN++  K  S    GL+ ++     ++F+  E+  +I+G    IDLDDL+ NT Y G  + D  + I  FW VL E   +EK NF++FVTS+ +AP+ GF  L PKF I+    +  RLPTASTC+NLLKLP Y+N   +REKLLYAI S + F
Sbjct:  494 SSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISRDNVLEDAFNAFN-SIGERFKASLDVTFINEFG-EEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPS----VVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLS-SFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEP-ESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEED--QTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARF 907

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BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 170.629 bits (431), Expect = 5.879e-44
Identity = 115/370 (31.08%), Postives = 203/370 (54.86%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYR--NLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSP-----KFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I++RR  ++EDA+ +I R+T  +L+  L I+F       E G+D GG+ REF   +  E  +P   LF   +  N  I  NP    + P    EHL++F   GR++GL +F    ++A    FF+  L+     R+++ + +++ +D ++Y   N +   S+D V  ++L F+     +G   TV+LKP+G +I VT+ NK EY+ L   +++  ++ +Q    ++G N+++P +   +FD  E+  +I GG + ID++D +++T Y G  + D  E+IQ FW+ + E   +++   +QF T  SR P+ GF +L       +F I+   +  +LP + TC N + LP Y + + M++KL  A+    GF
Sbjct:  457 IKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFD-----GEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPN-SGINP----EHLNYFKFIGRVVGLGVFHRRFLDA----FFVGALYK-MMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV--LDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLI-GGIAEIDIEDWKKHTDYRGYQESD--EVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGF 806

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BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 151.754 bits (382), Expect = 2.085e-37
Identity = 109/363 (30.03%), Postives = 187/363 (51.52%), Query Frame = 2

Query: 2195 PIRIRRDYLYEDAFSQIKRKTFTNLR-SYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSP-----KFAIQI-VPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIG 3256
            PI +RR+ ++ D++  +  KT   ++ S L+I F       E GVD GG+ RE+ + + ++  +P   LF  V +     +PN     + P    EHL FF + +G++I K +  +      F ++++ N   R  + + +++ LD D Y++L+ +   D  + I   F+V    YG  + + L   G+ I VT +NK +Y+  V +YKL   + +Q    + G   ++  +   +FD  E+  +I+G    ID+DD + NT Y  V+   + + +  FWR +     +E+   +QFVT  S+ P+ GF ELS      KF+I      ++RLP++ TC N L LP Y++ E +R  LL AI 
Sbjct: 2912 PITVRREQVFLDSYRALFFKTNDEIKNSKLEITF-----KGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPN-RTSGINP----EHLSFF-KFIGMIIGKAIRDQCFLDCHFSREVYKNILGRP-VSLKDMESLDPDYYKSLVWILENDITDIIEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPD-IDVDDWKNNTTY--VNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAIN 3259

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BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 120.939 bits (302), Expect = 3.144e-28
Identity = 115/421 (27.32%), Postives = 192/421 (45.61%), Query Frame = 2

Query: 2105 PFIIPIGTRMKLF-------------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFV----STKNNLIYPNPELETLYPDNWQEHLDF-FGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEID----------IDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIEC--FQLFDLDEISFIITGGD--SLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            PFI+ +G ++ +              +  L  ++   S  +   I++RRD +  D+   IK      L+S L+IEF+     NEPG+D GGL +E+   + K   +P  GLF+    S+++      P  +     N Q  L + FG ++GL IF   +++  F     +KL +   S E+            I  L Y  ED + ++ SL         N     S+S      TVEL  NG ++ +T SNK E++    ++ L + I  Q +  ++G   V   EC   +LF+ +E+  ++ G +  +  D   L+  T Y G    D S  +  FW ++       ++  +QFVT+  R P  G S +  K ++    D+D LP A TC N + L  Y + +++  KLL+AI    G+
Sbjct:  479 PFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKS-LRIEFV-----NEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYT-EDNFEDVFSLTFETTYRNNNWILNDSKSSKEYV-TVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFA-ECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVG-GFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889

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BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Match: UFD4 (Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001493])

HSP 1 Score: 83.5741 bits (205), Expect = 1.315e-16
Identity = 66/215 (30.70%), Postives = 100/215 (46.51%), Query Frame = 2

Query: 2669 VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDL-----DDLQRNTIYHGVDDPDS----SEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDR------LPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSG 3268
            +E ++L FTV  +       +EL P G + S+ +SN  EYI+ V D  L + I KQ    I G + V   E            +I   D L+D+     +D    T+Y  ++        S II  F  ++    + E+R F+QF+T   + P+ GF  L+PKF + +    D       LP+  TC N LKLP Y + + MR +L  AI   +G
Sbjct: 1279 LESLSLTFTVPGN-----DDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYE----------RMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAG 1478

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BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Match: EDO47399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLV6])

HSP 1 Score: 236.884 bits (603), Expect = 1.387e-64
Identity = 146/447 (32.66%), Postives = 237/447 (53.02%), Query Frame = 2

Query: 2054 SQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLG------GMNYPTSFAMIPP--IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVST--KNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIV--PDTD--------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            S++     R +++L+++P +IP   R++LF++ +       G+  P+   M     I   R+ L ED + Q+       L+  +++ FI+  G+ E G+D  G+ +EFL   IK A DP   LF  T  +   +YP+P   +   DN     +F G+MLG  +++G++VE  FA FF+  +  N  S     ID L  LD++LY++L  +K  D  + +++L F+      G   T +LKP G  I V++ NKI Y++L+A Y++  QI +QT   I G   +V  +  ++F   E+  +I+G ++ +DL DL+ +T Y+G        ++   W +L  E ++ EK  F++FVTS S+ P+LGF  L P F+I+ V  PD +                          RLPTASTC NLLKLP Y+    +R+KL YAI  ++GF+
Sbjct:  529 SELEVGKQRALLVLRKIPHVIPHKERVRLFRDFVAKDKESLGIARPSDDFMPQGTLITAHRNRLLEDGYDQLSVLPAHILKGLIRVRFINEQGLPEAGIDQDGVFKEFLEETIKHAFDPAFNLFKVTTGEEQRLYPSPT--SFIHDNHLLLYEFVGKMLGKAVYEGIVVEVPFAFFFLNHVLGNQHSNLYSSIDELPSLDQELYKSLTFIKHYDGDIRDLDLTFSFDEDVLGKVVTHQLKPGGTAIVVSDENKISYVHLMAHYRMCIQIREQTRAFIRGFKSIVHNDWLRMFSAPELQRLISGDNTALDLSDLRVHTRYYG-GYHGGHRVVVWLWEILDKEFNDQEKSLFLKFVTSCSKPPLLGFEHLEPPFSIRCVECPDDEDDGDTVGSVLRGFLNIRRRNARETVSRLPTASTCFNLLKLPNYRKKSTLRDKLRYAIQCNAGFE 972

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BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Match: EDO49327 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHD5])

HSP 1 Score: 176.792 bits (447), Expect = 1.341e-48
Identity = 115/366 (31.42%), Postives = 193/366 (52.73%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+E++F Q+ R    +LR  L I F       E G+D GG+ RE+   +  E  +P   LF  + KNN         ++ PD+   +  F GR + + ++ G  ++  F   F +++ N     +++ + +L+ +D + Y +L+ +K  + +EE  L+  FTV     G   + +LKP G  I+VT  NK EYI L+ +++LNR I +QT   + G+++V+P+   Q FD  E+  ++ G    ID++D Q+NT+Y       +S+ +  FW+ +     +++   +QFVT   R P+ GF+EL       KF I+ V     LP + TC N L LP Y++ E++ EKL +AI    GF
Sbjct:   11 ITVSRTNLFEESFQQVMRYQPHDLRRRLYITF-----KGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNNYSLQINAASSVNPDHLM-YFKFIGRFIAMALYHGKFIDRGFTLPFYKRMLN-----KKLLMKDLETIDPEFYNSLVWVKE-NNIEECGLEMFFTVDMELLGKVTSHDLKPGGTDIAVTEENKEEYISLMTEWRLNRGIEEQTRAFLEGMHEVLPLYWIQYFDERELELMLCGMQE-IDVEDWQQNTVYRHY--TRNSKQVMWFWQAVKAYDNEKRIRLLQFVTGTCRLPVGGFTELMGDNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLVEKLTFAIEETEGF 361

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Match: EDO49383 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG94])

HSP 1 Score: 166.007 bits (419), Expect = 4.006e-45
Identity = 105/339 (30.97%), Postives = 176/339 (51.92%), Query Frame = 2

Query: 2270 RSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSP-----KFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            R+ L+I+F       E G+D GG  REF   I ++  +P  GLF  + N+         +LY DN  E   F GR++GL+I    L++A F   F + L      R   D+ +++ LD   ++++  +   D  + ++L F+VS   +G     EL P G+ I+VT  NK +Y+  +  +++ R +S+Q   I+ G N+V+      +FD  E+  +I+ G + ID+ D +RNT Y      D+ ++++ FW+ +     +++   +QFVT  S  P  GF+ L       KF+I+   D  +LP A TC N L +P Y++ +E+ EKL YA+     F
Sbjct:   10 RNRLEIQF-----AGEEGLDYGGPAREFFFLISRQIFNPYYGLFEYSANDTYTVQVSPVSLYVDNSHEWFRFCGRIVGLVIIHQHLLDAFFTRTFYKALL-----RSLCDLSDVEALDALFHQSMTWVIENDIEDVLDLTFSVSEEIFGQVTERELIPGGKDIAVTEQNKGDYVAEMVKWRVERGVSEQMESIVRGFNEVIDPALVNIFDARELELVIS-GTADIDIKDWRRNTEYRS-GYHDNHKVVKWFWKAVSSFDNEQRLRLLQFVTGTSSIPYEGFAALRGSTGPRKFSIERWGDYTKLPRAHTCFNRLDMPIYRSYDELLEKLTYAVEETGSF 336

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Match: EDO46071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR93])

HSP 1 Score: 162.925 bits (411), Expect = 9.974e-41
Identity = 125/374 (33.42%), Postives = 190/374 (50.80%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTN--LRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF-VSTKNNL---IYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITG-GDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            I IRR  L ED++  ++        L+S L I F       E G+D GGL RE+   + KE  +P  GLF  S  +N    I PN  L        +EHL +F   GR+ G+ ++ G L++A    FFI+  +     R  I + +++ +D + Y +L  +   D  E+++L F V    +G+    +LKPNG   +VTN NK EYI LV  ++   ++  Q    + G  D++P    Q+FD  E+  ++ G G+  ID  D ++N+ Y G +  D   +IQ FW+ +     + +   +QFVT  SR PM GFSEL       +F I+       LP A TC N L LP Y++  E+RE+L  AI +  GF+
Sbjct:  633 IHIRRRNLMEDSYRAVQLSIVKPEILKSRLWIVFD-----GETGLDYGGLQREWFYLLSKEVFNPYYGLFEYSASDNYTLQINPNSGLCN------EEHLSYFKFIGRVAGMAVYHGKLLDA----FFIRPFYKMMLGRP-ITLIDMESVDSEYYNSLNWILEND-PEDLDLHFCVDEELFGILSVKDLKPNGSQTNVTNENKREYINLVIKWRFVSRVEDQMRAFMEGFCDLIPHNLIQIFDERELELLMCGLGE--IDTVDWRKNSNYRG-EYHDKHIVIQWFWKAVNSFDIETRARLLQFVTGTSRVPMNGFSELYGSNGPQRFTIEPWGTPHSLPRAHTCFNRLDLPRYRSYYELRERLRIAIENTQGFE 986

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Match: EDO40302 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7U7])

HSP 1 Score: 154.836 bits (390), Expect = 7.079e-39
Identity = 121/377 (32.10%), Postives = 186/377 (49.34%), Query Frame = 2

Query: 2162 MNYPTSFAMIP--PIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPE-LETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSE--IIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            +N     AM P   + +RRD+L  D  SQI  K + +L+  LKI+++   G  E G+D GGL +EF   I+    +P  G+F   + +  ++ N E  E+L      +  +  G +LGL I+ G++++  F     +KL   + S E  D+  +Q    +  + LL  +  D  +     F VS   YG     EL PNG  + V N N+ E+++    Y L   ++KQ      G + V       LF  DE+  +I G   ++D  DL     Y   DD  S++   I+ FW V  EM+  +K+  + FVT   R P+ G S L+  F IQ    D+DRLPTA TC N L LP Y + + ++E+L+ AI +  GF
Sbjct:  337 LNDGVKAAMCPFLVLEVRRDHLIRDTLSQIHLKEY-DLKKPLKIKYV---GGGELGLDMGGLQKEFFHMIVDSIFEPGYGMFTYIEESRTMWINGESFESL------KEFELVGIVLGLAIYNGIILDIHFPQVIYKKLQGQTPSLE--DLIGVQPSLGNSLKQLLEYEG-DVEDTFCYTFQVSAMSYGKVCDRELIPNGAEVPVNNENREEFVHRYVKYLLVDSVAKQFDAFSAGFHKVCGGSALTLFCADELELLICG-HHVLDFSDLVLAASY---DDGYSAQHSTIKMFWNVFNEMTNHQKKALLMFVTGSDRVPLKGLSNLT--FIIQKHGQDSDRLPTAMTCFNRLLLPEYTSPKRLKERLIVAIENSKGF 694

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:101155064])

HSP 1 Score: 341.658 bits (875), Expect = 1.105e-99
Identity = 204/585 (34.87%), Postives = 325/585 (55.56%), Query Frame = 2

Query: 1625 FANCLHWRLLSVQDLDLI--KIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQ------------PNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKP-------GLCRINVENFKRYFESLYINYKFGTIRSS--------QVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGG----MNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSM-DRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQ-IVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            F++     L+SV D +    +++    S ++ F+  EL  +   LRD   G+I L YP        +             N V    Q   ++ V++F  +  +V  +  RD+R+     G    W+          + ++ V + +  + +  +  + G ++S+        Q++ S+ R + IL E+PF++P   R+K+F+ L+      +     F+    + IRR+Y+YEDA+ ++  +   +L+  +++  ++  G++E G+DGGG+ REFL  ++K   +P +G F +T   L+YPNP  E L  +++  H  F GR+LG  +++ +LVE  FA FF+ KL   S+   ++DI +L  LD ++YRNLL LKS  D VEE+ L+FTV  +  G +Q VELKP G+ I VT +N+I YI+LVADY+LN+ +         GL +VV +E  ++FD  EI  +I+G    I L+DL+  T Y G    +   +IQ FW V+   +E+EKR  ++FVTS SR P+LGF EL P F I     D +RLPTASTC+NLLKLP + + + MR KLLYAI S +GF+
Sbjct:  503 FSSLFSHSLISVHDSEFFGHEMEGHVQSFMMPFTLSELVALSRCLRDACLGIIKLAYPETKTEHREEYMAAFRSVGVKTNNEVQQRIQAEQKRWVQLFKVITNLVKMVKARDIRRPFCPEG---HWLSDEVNIRADKVTQLYVPSARHVWRTRRMG-RIGPLQSTLDVGLEPPQLSVSEERNLAILTELPFVVPFEERVKIFQRLIFADKRDVQGDGPFSDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTSA---DVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKHMRPHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAYVPISLEDLKNFTNYSGGYSANHP-VIQIFWEVVEGFTEEEKRKLLRFVTSCSRPPLLGFKELHPAFCIHNGGSDLERLPTASTCMNLLKLPEFCDQQSMRSKLLYAIESSAGFE 1079

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:101170594])

HSP 1 Score: 249.595 bits (636), Expect = 3.231e-68
Identity = 145/434 (33.41%), Postives = 240/434 (55.30%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  +  +YP+P   +   +N     +F G+MLG  I++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ I VTN NKI YI+L+A ++++ QI +QT+  I G   ++  E   +F   E+  +++G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + +E+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  575 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKESLGLIETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGDERLYPSPT--SYIHENHLLLFEFVGKMLGKAIYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVGDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRCIINPEWLHMFSTPEVQRLVSGDNAEIDLDDLKKHTVYYG-GFHSSHRVIIWLWDILSSDFNAEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 1005

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:101170594])

HSP 1 Score: 249.98 bits (637), Expect = 4.841e-68
Identity = 145/434 (33.41%), Postives = 240/434 (55.30%), Query Frame = 2

Query: 2078 RQIVILKEMPFIIPIGTRMKLF-------KELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNN-LIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVL-FEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD-------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            R  ++L+ +P +IP   R+ LF       KE LG +   ++   +  I IRR  + ED + Q++R    +++  ++++F++  G++E G+D  G+ +EFL  IIK+  +P   LF +T  +  +YP+P   +   +N     +F G+MLG  I++G++V+  FA FF+ ++  +  S     ID L  LD + Y+NL S+K  D  V ++ L  +      G     EL P G+ I VTN NKI YI+L+A ++++ QI +QT+  I G   ++  E   +F   E+  +++G ++ IDLDDL+++T+Y+G     S  +I   W +L  + + +E+  F++FVTS SR P+LGF+ L P F+I+ V  +D                         RLPT+STC NLLKLP Y     +R+KL YAI  ++GF+
Sbjct:  636 RAQLLLQYIPHVIPHKNRVLLFRNIVTKEKESLGLIETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGDERLYPSPT--SYIHENHLLLFEFVGKMLGKAIYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVGDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRCIINPEWLHMFSTPEVQRLVSGDNAEIDLDDLKKHTVYYG-GFHSSHRVIIWLWDILSSDFNAEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFE 1066

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Match: itcha (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:101167949])

HSP 1 Score: 188.734 bits (478), Expect = 5.835e-49
Identity = 125/367 (34.06%), Postives = 196/367 (53.41%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L I F       E G+D GG+ RE+   +  E  +P   LF      N  +  NP    + PD+  ++  F GR + + +F G  ++  F+  F +++ N     + + + +L+ +D + Y +L+ +K  + +EE  L+  F+V +   G   T ELKP+G +I VT  NK EYI LVA+++L+R + +QT     G N+V+P +  Q FD  E+  ++ G    IDL D QRNTIY      +S +II  FW+ + EM  +++   +QFV    R PM GF++L       KF I+ V   + LP + TC N L LP Y+  E+++EKL++AI    GF
Sbjct:  443 ITVSRKTLFEDSFQQIMSFHPQDLRRRLWIIFP-----GEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINP-ASYINPDH-LKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILN-----KPLTLKDLESIDPEFYNSLIWIKD-NNIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEDNKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQE-IDLADWQRNTIYRHYAR-NSKQIIW-FWQFVKEMDNEKRMRLLQFVAGTCRLPMGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKTYEQLKEKLMFAIEETEGF 793

[Close]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Match: itchb (E3 ubiquitin-protein ligase Itchy [Source:NCBI gene;Acc:101174746])

HSP 1 Score: 186.808 bits (473), Expect = 1.917e-48
Identity = 123/367 (33.51%), Postives = 196/367 (53.41%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLD--FTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I + R  L+ED+F QI      +LR  L I F       E G+D GG+ RE+   +  E  +P   LF      N  +  NP   ++ PD+  ++  F GR + + +F G  +   F+  F +++ N     + + + +L+ +D + Y +L+ +K  + +EE  L+  F+V +   G   T ELKP G  I VT  NK EYI LVA+++L+R + +QT     G N+V+P +  Q FD  E+  ++ G    IDL D QRNTIY       +S+ I  FW+++ EM  +++   +QFVT   R P+ GF++L       KF I+ V   + LP + TC N L LP Y++ E+++EK+++AI    GF
Sbjct:  434 INVTRKNLFEDSFQQIMSINAPDLRRRLWIIFP-----GEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINP-ASSINPDH-LKYFRFIGRFIAMALFHGKFINTGFSLPFYKRILN-----KPLAVKDLESIDPEFYNSLMWIKD-NNIEECCLEMFFSVDKEILGEITTHELKPGGGDIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQD-IDLADWQRNTIYRHY--ARNSKQILWFWQLVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKVMFAIEETEGF 784

[Close]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Match: SMESG000055056.1 (SMESG000055056.1)

HSP 1 Score: 2107.03 bits (5458), Expect = 0.000e+0
Identity = 1087/1088 (99.91%), Postives = 1088/1088 (100.00%), Query Frame = 2

Query:   11 MFSFEGHYKKPRSVNYGKQKDVGKKDLIENARSEREKRALLTRQIKSATLIQNAFRKYSNRKKIKNQAFNKFQQLQIEISILNQNEPKYFETILKLIDCLLKFFNPNTDDNNLKSLITLLNKTDTVKRFFSDIYVHSYYPTVSMSLLLRSTAKYLKSFPENSPPINYNIFLRFFEKCFSCFDSITDERNLTNCRHKLFFQILLNSKYFNHISEFINSQLVGKNESAYHLCGQMKVKSVLNILLAPIDKTANCDLSTLALIQYVNNIYSVKNSSLPDSLCALKLMSIALLDIISLNAFIDTVFQSFNSSNQILYFKISPGXXXXXXXAVVDIKMDSVSVEIAAKTLVLFFKISRTLLDRNQLFLSNDLPECLKLSTETPSTVVRDDLDFXXXXXXXXXXXXXXXXXXXXXXXAVAIPLKMSIIEQEIALILKSKFCQVIVTQATQLXXXXXXXXXXXXXXXGYLYHLLILETKIIGSSESKTFILSLIQTSKTVSRRLWGSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            MFSFEGHYKKPRSVNYGKQKDVGKKDLIENARSEREKRALLTRQIKSATLIQNAFRKYSNRKKIKNQAFNKFQQLQIEISILNQNEPKYFETILKLIDCLLKFFNPNTDDNNLKSLITLLNKTDTVKRFFSDIYVHSYYPTVSMSLLLRSTAKYLKSFPENSPPINYNIFLRFFEKCFSCFDSITDERNLTNCRHKLFFQILLNSKYFNHISEFINSQLVGKNESAYHLCGQMKVKSVLNILLAPIDKTANCDLSTLALIQYVNNIYSVKNSSLPDSLCALKLMSIALLDIISLN+FIDTVFQSFNSSNQILYFKISPGLLLLILIAVVDIKMDSVSVEIAAKTLVLFFKISRTLLDRNQLFLSNDLPECLKLSTETPSTVVRDDLDFEMKSIEEENEISSEEEMSESQSMAVAIPLKMSIIEQEIALILKSKFCQVIVTQATQLDNDSIIDKKSIYDSIGYLYHLLILETKIIGSSESKTFILSLIQTSKTVSRRLWGSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ
Sbjct:    1 MFSFEGHYKKPRSVNYGKQKDVGKKDLIENARSEREKRALLTRQIKSATLIQNAFRKYSNRKKIKNQAFNKFQQLQIEISILNQNEPKYFETILKLIDCLLKFFNPNTDDNNLKSLITLLNKTDTVKRFFSDIYVHSYYPTVSMSLLLRSTAKYLKSFPENSPPINYNIFLRFFEKCFSCFDSITDERNLTNCRHKLFFQILLNSKYFNHISEFINSQLVGKNESAYHLCGQMKVKSVLNILLAPIDKTANCDLSTLALIQYVNNIYSVKNSSLPDSLCALKLMSIALLDIISLNSFIDTVFQSFNSSNQILYFKISPGLLLLILIAVVDIKMDSVSVEIAAKTLVLFFKISRTLLDRNQLFLSNDLPECLKLSTETPSTVVRDDLDFEMKSIEEENEISSEEEMSESQSMAVAIPLKMSIIEQEIALILKSKFCQVIVTQATQLDNDSIIDKKSIYDSIGYLYHLLILETKIIGSSESKTFILSLIQTSKTVSRRLWGSAVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSVQDLDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSKYNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEWVKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPFIIPIGTRMKLFKELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 1088

[Close]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Match: SMESG000048038.1 (SMESG000048038.1)

HSP 1 Score: 239.965 bits (611), Expect = 8.654e-65
Identity = 147/435 (33.79%), Postives = 230/435 (52.87%), Query Frame = 2

Query: 2090 ILKEMPFIIPIGTRMKLFKE-----------LLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMD-RVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD---------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            +LK +P II    R+ LF E           L    N+  S  +   I +RR  + ED + Q+ +    + +  +++ FI+  GM+E G+D  G+ +EFL   +K   +P   LF +T +N +YP+P L  LY  N      + GRM+   I++ +L+EA FA FF+ ++ +   S     ID L  LD+DLY++L  +K  D  V ++ L F+      G  +T +L+P G +I+VTN  KI Y+++VA +++ +QI  QT     G   ++  + F +F + E+  +I G   LID+DDL++N  Y G        +I   W +L  E SE+EK  F++FVTS S+ P+LGF+ L P F+I+ V  +D                           RLP+A+TC NLLKLP Y++   +REKL Y I S +GF+
Sbjct:  674 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDS-PIGAVISVRRQRIVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVFKEFLEETLKTLLNPSLNLFCTTSDNRLYPSP-LSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHA-GHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 1105

[Close]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 170.244 bits (430), Expect = 5.105e-43
Identity = 116/367 (31.61%), Postives = 192/367 (52.32%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSY-LKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            +RI R  ++ED++  I     T +  Y L IEFI      E G+D GG+ RE+   + +E  +P  GLF   +  N  +  NP L  +  +N   +  F GR+ G+ ++ G L++     FFI+ L+     ++ I + +++ +D + YR+L  +   D    ++L F+V    +G    V+L P+G   +VT  NK +YI  + +++  +++  Q +  + G  DVV +   Q+FD +E+  ++ G    I++ D + NT Y G  +P+   +I  FW+ ++  + + +   +QFVT  SR PM GF EL       KF I+     D+LP A TC N L LP Y   EE+R KLL AI +  GF+
Sbjct:  507 MRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFI-----GEKGLDYGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINP-LSGVANENHLRYFKFIGRVAGMAVYHGRLLDG----FFIRPLYKMMLGKK-ISLKDMESVDTEYYRSLKFILENDPAV-LDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQD-INVTDWKGNTNYKGEYNPNHP-VIVNFWKTVYTFNNELRSRLLQFVTGTSRVPMNGFVELWGSTGPQKFTIEKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGFE 859

[Close]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 170.244 bits (430), Expect = 7.551e-43
Identity = 116/367 (31.61%), Postives = 192/367 (52.32%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSY-LKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQ 3274
            +RI R  ++ED++  I     T +  Y L IEFI      E G+D GG+ RE+   + +E  +P  GLF   +  N  +  NP L  +  +N   +  F GR+ G+ ++ G L++     FFI+ L+     ++ I + +++ +D + YR+L  +   D    ++L F+V    +G    V+L P+G   +VT  NK +YI  + +++  +++  Q +  + G  DVV +   Q+FD +E+  ++ G    I++ D + NT Y G  +P+   +I  FW+ ++  + + +   +QFVT  SR PM GF EL       KF I+     D+LP A TC N L LP Y   EE+R KLL AI +  GF+
Sbjct:  547 MRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFI-----GEKGLDYGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINP-LSGVANENHLRYFKFIGRVAGMAVYHGRLLDG----FFIRPLYKMMLGKK-ISLKDMESVDTEYYRSLKFILENDPAV-LDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQD-INVTDWKGNTNYKGEYNPNHP-VIVNFWKTVYTFNNELRSRLLQFVTGTSRVPMNGFVELWGSTGPQKFTIEKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGFE 899

[Close]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Match: SMESG000008708.1 (SMESG000008708.1)

HSP 1 Score: 167.933 bits (424), Expect = 1.493e-42
Identity = 118/369 (31.98%), Postives = 193/369 (52.30%), Query Frame = 2

Query: 2198 IRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLF--VSTKNNLIYPNPELETLYPDNWQEHLDFF---GRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVE-EINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSEL-----SPKFAIQIVPDTDRLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGF 3271
            I +RR+ L ED+F++I R    +L+  L I+F D     E G+D GG+ RE+   +  E  +P   LF   S  N  +  NP    + P    EHL +F   GR + + +F    +++ F   F +K+       + I + +++ +D + Y +L  ++  +  E ++ L F+     +G  +  ELK NG  I VT  NK EYI L+ +++ +R + +QT   ++G N++VP+   Q++D  +I  ++ G    ID+ D + N+IY  V   DS + I+ FW  + ++  DEK   +QFVT   R P+ GF EL       KF I+ +     LP + TC N L LP Y + E+++EKL YA+    GF
Sbjct:  392 IIVRRNMLMEDSFNEIMRVKPKDLQKRLFIQFKD-----EDGLDYGGISREWFFQLSHELLNPMYCLFEYASDNNYSLQINP-ASFINP----EHLQYFRFVGRFVAMAMFHRKFIDSGFTIPFYKKMLG-----KRITLQDIETVDVEYYNSLKFIRDNNIDECDMGLVFSAEYELFGKIEEQELKTNGRDIEVTEENKNEYIDLMVNWRFSRGVVEQTKAFMDGFNEIVPLHWLQVYDERQIELLLCGMQQ-IDVKDWEANSIYR-VYTKDSPQ-IKWFWEFVGKLPNDEKIRLLQFVTGTCRLPVGGFRELMGSNGPQKFCIEKIGKESWLPRSHTCFNRLDLPPYASYEQLKEKLTYAVMETEGF 742

The following BLAST results are available for this feature:

BLAST of Ubiquitin protein ligase vs. Ensembl Human
BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
BLAST of Ubiquitin protein ligase vs. Ensembl Fly
BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
BLAST of Ubiquitin protein ligase vs. TrEMBL
BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
BLAST of Ubiquitin protein ligase vs. Planmine SMEST

BLAST of Ubiquitin protein ligase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBE3C	4.244e-98	34.22	ubiquitin protein ligase E3C [Source:HGNC Symbol;A...	[more]
UBE3B	7.189e-70	33.64	ubiquitin protein ligase E3B [Source:HGNC Symbol;A...	[more]
UBE3B	7.189e-70	33.64	ubiquitin protein ligase E3B [Source:HGNC Symbol;A...	[more]
WWP2	5.604e-50	33.88	WW domain containing E3 ubiquitin protein ligase 2...	[more]
NEDD4L	3.925e-47	32.56	NEDD4 like E3 ubiquitin protein ligase [Source:HGN...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
etc-1	1.225e-76	30.07	E3 ubiquitin-protein ligase etc-1 [Source:UniProt...	[more]
oxi-1	2.514e-63	30.18	OXidative stress Induced [Source:UniProtKB/TrEMBL...	[more]
Y92H12A.2	8.262e-54	35.73	E3 ubiquitin-protein ligase [Source:UniProtKB/TrE...	[more]
wwp-1	1.520e-49	31.88	E3 ubiquitin-protein ligase [Source:UniProtKB/TrE...	[more]
wwp-1	1.520e-49	31.88	E3 ubiquitin-protein ligase [Source:UniProtKB/TrE...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG3356	7.831e-105	35.75	gene:FBgn0034989 transcript:FBtr0072262	[more]
CG5087	2.813e-70	31.47	gene:FBgn0035953 transcript:FBtr0333908	[more]
CG5087	3.444e-70	31.65	gene:FBgn0035953 transcript:FBtr0076520	[more]
Nedd4	3.751e-45	33.68	gene:FBgn0259174 transcript:FBtr0300520	[more]
Nedd4	3.753e-45	33.68	gene:FBgn0259174 transcript:FBtr0299642	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ube3c	1.463e-99	33.80	ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-...	[more]
ube3b	7.961e-70	33.64	ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-...	[more]
ube3c	2.729e-64	30.78	ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-...	[more]
itcha	5.418e-50	34.33	itchy E3 ubiquitin protein ligase a [Source:ZFIN;A...	[more]
wwp1	2.575e-47	32.43	WW domain containing E3 ubiquitin protein ligase 1...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rpa1	1.195e-97	34.07	replication protein A1 [Source:Xenbase;Acc:XB-GENE...	[more]
rpa1	1.513e-97	34.07	replication protein A1 [Source:Xenbase;Acc:XB-GENE...	[more]
rpa1	1.789e-88	34.60	replication protein A1 [Source:Xenbase;Acc:XB-GENE...	[more]
rpa1	5.133e-74	32.36	replication protein A1 [Source:Xenbase;Acc:XB-GENE...	[more]
ube3b	5.890e-70	34.10	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ube3c	7.836e-98	33.95	ubiquitin protein ligase E3C [Source:MGI Symbol;Ac...	[more]
Ube3b	6.980e-69	32.49	ubiquitin protein ligase E3B [Source:MGI Symbol;Ac...	[more]
Wwp2	2.217e-50	33.88	WW domain containing E3 ubiquitin protein ligase 2...	[more]
Nedd4l	1.928e-48	32.12	neural precursor cell expressed, developmentally d...	[more]
Nedd4l	1.580e-46	32.56	neural precursor cell expressed, developmentally d...	[more]

BLAST of Ubiquitin protein ligase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q15386\|UBE3C_HUMAN	2.038e-97	34.22	Ubiquitin-protein ligase E3C OS=Homo sapiens OX=96...	[more]
sp\|Q80U95\|UBE3C_MOUSE	5.481e-97	33.95	Ubiquitin-protein ligase E3C OS=Mus musculus OX=10...	[more]
sp\|Q9SCQ2\|UPL7_ARATH	6.258e-76	36.48	E3 ubiquitin-protein ligase UPL7 OS=Arabidopsis th...	[more]
sp\|O17736\|ETC1_CAEEL	1.558e-75	30.07	E3 ubiquitin-protein ligase etc-1 OS=Caenorhabditi...	[more]
sp\|Q8RWB8\|UPL6_ARATH	3.726e-74	36.04	E3 ubiquitin-protein ligase UPL6 OS=Arabidopsis th...	[more]

BLAST of Ubiquitin protein ligase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0P4W9I2	5.786e-109	40.92	HECT domain-containing protein OS=Scylla olivacea ...	[more]
T2MCI0	5.417e-106	37.83	Ubiquitin-protein ligase E3C (Fragment) OS=Hydra v...	[more]
A0A1A8K3S8	7.333e-104	35.06	Ubiquitin protein ligase E3C (Fragment) OS=Nothobr...	[more]
A0A0R3X0Q3	8.845e-104	33.19	HECT domain-containing protein OS=Hydatigena taeni...	[more]
V4B5L0	2.162e-103	35.96	HECT domain-containing protein OS=Lottia gigantea ...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ube3c	1.634e-99	33.64	ubiquitin protein ligase E3C [Source:NCBI gene;Acc...	[more]
ube3c	3.088e-99	33.64	ubiquitin protein ligase E3C [Source:NCBI gene;Acc...	[more]
ube3b	7.511e-70	33.64	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]
ube3b	1.480e-69	33.64	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]
ube3b	1.480e-69	33.64	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ube3c	6.925e-98	36.06	ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-...	[more]
ube3b	6.591e-68	30.21	ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-...	[more]
nedd4a	4.881e-48	32.06	NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A...	[more]
wwp2	1.004e-40	33.13	WW domain containing E3 ubiquitin protein ligase 2...	[more]
ube3a	5.222e-39	31.12	ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
HUL5	1.961e-61	36.08	Multiubiquitin chain assembly factor (E4); proteas...	[more]
RSP5	5.879e-44	31.08	NEDD4 family E3 ubiquitin ligase; regulates proces...	[more]
TOM1	2.085e-37	30.03	E3 ubiquitin ligase of the hect-domain class; has ...	[more]
HUL4	3.144e-28	27.32	Protein with similarity to hect domain E3 ubiquiti...	[more]
UFD4	1.315e-16	30.70	Ubiquitin-protein ligase (E3); interacts with Rpt4...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47399	1.387e-64	32.66	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49327	1.341e-48	31.42	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49383	4.006e-45	30.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46071	9.974e-41	33.42	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40302	7.079e-39	32.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Ubiquitin protein ligase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ube3c	1.105e-99	34.87	ubiquitin protein ligase E3C [Source:NCBI gene;Acc...	[more]
ube3b	3.231e-68	33.41	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]
ube3b	4.841e-68	33.41	ubiquitin protein ligase E3B [Source:NCBI gene;Acc...	[more]
itcha	5.835e-49	34.06	E3 ubiquitin-protein ligase Itchy [Source:NCBI gen...	[more]
itchb	1.917e-48	33.51	E3 ubiquitin-protein ligase Itchy [Source:NCBI gen...	[more]

BLAST of Ubiquitin protein ligase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000055056.1	0.000e+0	99.91	SMESG000055056.1	[more]
SMESG000048038.1	8.654e-65	33.79	SMESG000048038.1	[more]
SMESG000013095.1	5.105e-43	31.61	SMESG000013095.1	[more]
SMESG000013095.1	7.551e-43	31.61	SMESG000013095.1	[more]
SMESG000008708.1	1.493e-42	31.98	SMESG000008708.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013617 ID=SMED30013617|Name=Ubiquitin protein ligase|organism=Schmidtea mediterranea sexual|type=transcript|length=3392bp
CTTTTAAATTATGTTTTCTTTTGAAGGTCATTACAAAAAGCCAAGATCAG
TAAATTATGGTAAACAAAAAGATGTAGGTAAAAAAGATCTAATTGAAAAT
GCTCGGTCAGAAAGAGAAAAGCGAGCTTTATTAACTCGTCAAATCAAAAG
TGCAACTTTAATTCAAAATGCTTTTAGAAAGTATTCTAACCGAAAAAAAA
TTAAAAATCAGGCATTTAATAAATTTCAACAATTACAAATTGAAATTTCA
ATATTAAATCAAAATGAGCCTAAATACTTTGAAACCATTCTTAAGTTAAT
TGATTGCTTATTGAAATTTTTTAATCCAAACACAGATGATAATAATTTGA
AATCATTGATCACGCTGCTCAATAAAACCGATACCGTAAAACGATTCTTC
AGTGACATCTATGTTCACAGTTATTACCCAACCGTTTCAATGAGCCTTTT
GTTACGTTCAACCGCAAAATATTTAAAATCCTTCCCAGAAAATTCACCGC
CCATCAATTACAATATATTTTTGAGATTTTTTGAGAAATGTTTTTCTTGT
TTTGATTCGATAACCGACGAAAGAAATTTGACCAACTGCCGCCATAAACT
ATTTTTCCAGATCTTATTGAACTCGAAATATTTTAATCATATATCAGAAT
TTATAAACTCACAACTGGTCGGGAAAAACGAGTCTGCATATCATCTTTGC
GGTCAAATGAAAGTAAAATCCGTTCTTAACATTCTTTTGGCGCCAATCGA
TAAAACCGCAAATTGTGATCTTTCAACTCTCGCACTCATCCAATATGTGA
ATAACATCTACTCAGTGAAAAACTCGAGTTTACCAGATTCTCTCTGCGCA
TTGAAATTGATGTCCATCGCGTTACTCGATATCATTTCACTGAACGCATT
CATCGACACAGTTTTCCAAAGCTTTAACTCGTCCAATCAAATCTTATATT
TCAAAATTTCTCCCGGTCTTCTTCTGTTAATTCTTATTGCCGTTGTCGAT
ATCAAAATGGATTCGGTTTCAGTGGAAATTGCCGCTAAAACTCTGGTTTT
ATTCTTTAAAATCTCGCGTACATTGTTAGACAGGAATCAGTTGTTTCTCT
CTAATGATTTGCCGGAGTGTTTGAAACTGTCAACGGAAACCCCATCGACA
GTTGTTAGAGATGATTTGGATTTCGAAATGAAAAGCATTGAAGAGGAAAA
CGAAATTTCATCAGAAGAAGAAATGAGTGAGTCGCAATCGATGGCGGTTG
CGATTCCATTGAAAATGTCGATAATCGAGCAGGAAATTGCACTGATATTG
AAATCGAAATTCTGTCAAGTCATAGTAACCCAGGCCACTCAACTCGACAA
TGATTCCATTATCGATAAAAAGTCAATCTACGATTCCATTGGTTATCTTT
ATCATTTGTTGATTTTGGAAACTAAAATCATCGGCAGTTCTGAATCGAAA
ACTTTCATTCTCAGTCTCATTCAAACGAGTAAAACCGTTTCCCGGAGATT
GTGGGGATCGGCTGTTGAACAGAAAACCAAAGACGGAGATTTAACTCTGA
TGCAGTCGTTGATTTTAGGCCAAATCCGCTCGATCGATACCGACATGAAA
GAGTTCTTTGGAAAGCTGTTGTGTTTTGCCAATTGTCTCCATTGGCGACT
GCTCAGTGTTCAGGATTTAGATTTGATAAAAATCGATTCCGAAGACTCAT
CAAAAGTGATCGAGTTCTCACCGGATGAATTGTGTGAAATCGTTCTCAAG
CTCCGTGACATAATGTACGGTCTCATCCTCCTCATATATCCTCTCATCAA
TCAATCGAAATACAACCAACCCAACACAGTGGCAAATTCTCATCAGATTT
GCACCGAAAAACTCGTGAAAATGTTTATCGAACTCCAACGAGTCGTGATT
CGTCTTTATAATCGCGACGTGAGGAAAGGTCTGAAAATGTCCGGGAAACG
GTTGGAATGGGTAAAACCGGGCCTCTGTCGAATAAACGTCGAAAATTTCA
AGAGATATTTCGAATCGCTCTATATCAACTACAAATTCGGCACAATTCGA
TCGTCACAAGTCACCTCATCGGATTGGAGGCAGATTGTAATTCTGAAAGA
AATGCCATTCATCATTCCGATTGGTACGAGAATGAAACTATTCAAAGAAC
TTCTCGGTGGCATGAATTATCCCACGTCTTTCGCTATGATTCCACCGATT
AGAATCCGTCGAGACTATCTCTATGAGGATGCATTTTCACAGATTAAACG
GAAAACTTTCACAAATCTCCGCTCGTATTTGAAAATCGAATTCATCGATC
GATTCGGAATGAATGAGCCCGGTGTCGATGGCGGAGGCCTGCTGAGGGAA
TTCCTGAGAAACATCATCAAAGAAGCCTGCGATCCGAAACGGGGATTGTT
TGTGTCGACGAAAAACAATCTCATCTATCCGAATCCGGAATTGGAGACTC
TCTATCCCGATAATTGGCAGGAGCATTTGGATTTCTTCGGTCGAATGTTG
GGTTTGATGATTTTCAAGGGTCTCCTCGTTGAGGCGTCATTTGCGCCGTT
TTTCATTCAGAAACTCTTCAACAACTCCTCATCCCGCGAGGAGATCGATA
TCGACAATCTACAGTACCTCGACGAGGATCTCTATCGGAATCTGTTGTCG
CTGAAATCAATGGACCGGGTCGAGGAGATCAATCTCGATTTCACGGTTTC
CCGCTCGTGTTACGGAGTCTCTCAGACGGTGGAATTGAAACCGAACGGGG
AACACATCTCGGTGACGAATTCCAACAAAATCGAATACATCTATCTCGTG
GCCGATTACAAGCTCAACCGGCAGATCTCCAAGCAGACATCATTGATTAT
CAACGGATTGAATGATGTGGTACCGATAGAGTGTTTCCAGCTGTTCGATT
TGGATGAGATCTCCTTCATTATCACCGGAGGTGATTCCTTGATCGATCTC
GATGATCTCCAACGGAATACGATCTATCATGGAGTCGATGATCCCGACAG
TTCCGAAATCATTCAGACGTTTTGGAGAGTGCTTTTCGAGATGTCCGAAG
ACGAGAAACGGAATTTCATTCAGTTTGTCACCTCGATTTCCAGAGCTCCG
ATGCTCGGGTTCTCGGAGCTCAGTCCGAAATTCGCTATTCAAATTGTACC
GGACACAGATCGATTGCCGACGGCAAGCACCTGCATTAATCTGCTGAAGT
TGCCAGCCTATCAGAACTTGGAGGAAATGAGAGAGAAACTTTTGTATGCG
ATTGGATCAGATTCAGGTTTCCAGCTGAGCTAATCTCTGTGCTTGTGTGC
TTGTGTGTGTGTGTAATATTTGATCTTTCATTTTCAATTATTATTTTTGT
AATAAACATGCATTGTTAAAAATTATATTCAATTTGTGTTGA

protein sequence of SMED30013617-orf-1

>SMED30013617-orf-1 ID=SMED30013617-orf-1|Name=SMED30013617-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1091bp
MFSFEGHYKKPRSVNYGKQKDVGKKDLIENARSEREKRALLTRQIKSATL
IQNAFRKYSNRKKIKNQAFNKFQQLQIEISILNQNEPKYFETILKLIDCL
LKFFNPNTDDNNLKSLITLLNKTDTVKRFFSDIYVHSYYPTVSMSLLLRS
TAKYLKSFPENSPPINYNIFLRFFEKCFSCFDSITDERNLTNCRHKLFFQ
ILLNSKYFNHISEFINSQLVGKNESAYHLCGQMKVKSVLNILLAPIDKTA
NCDLSTLALIQYVNNIYSVKNSSLPDSLCALKLMSIALLDIISLNAFIDT
VFQSFNSSNQILYFKISPGLLLLILIAVVDIKMDSVSVEIAAKTLVLFFK
ISRTLLDRNQLFLSNDLPECLKLSTETPSTVVRDDLDFEMKSIEEENEIS
SEEEMSESQSMAVAIPLKMSIIEQEIALILKSKFCQVIVTQATQLDNDSI
IDKKSIYDSIGYLYHLLILETKIIGSSESKTFILSLIQTSKTVSRRLWGS
AVEQKTKDGDLTLMQSLILGQIRSIDTDMKEFFGKLLCFANCLHWRLLSV
QDLDLIKIDSEDSSKVIEFSPDELCEIVLKLRDIMYGLILLIYPLINQSK
YNQPNTVANSHQICTEKLVKMFIELQRVVIRLYNRDVRKGLKMSGKRLEW
VKPGLCRINVENFKRYFESLYINYKFGTIRSSQVTSSDWRQIVILKEMPF
IIPIGTRMKLFKELLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTF
TNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVST
KNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQ
KLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDRVEEINLDFTVSRSC
YGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGL
NDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEI
IQTFWRVLFEMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD
RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQLS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR035983	Hect_E3_ubiquitin_ligase
IPR000569	HECT_dom
IPR000048	IQ_motif_EF-hand-BS

Vocabulary: **molecular function**
Term	Definition
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016874	ligase activity

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 65..85
None	No IPR available	COILS	Coil	Coil	coord: 24..44
None	No IPR available	GENE3D	G3DSA:3.30.2410.10		coord: 977..1089 e-value: 1.3E-34 score: 120.6
None	No IPR available	GENE3D	G3DSA:3.30.2160.10		coord: 855..938 e-value: 5.1E-65 score: 221.3
None	No IPR available	GENE3D	G3DSA:3.90.1750.10		coord: 730..973 e-value: 5.1E-65 score: 221.3
None	No IPR available	PANTHER	PTHR45700:SF2	UBIQUITIN-PROTEIN LIGASE E3C	coord: 3..1090
None	No IPR available	PANTHER	PTHR45700	FAMILY NOT NAMED	coord: 3..1090
IPR000569	HECT domain	SMART	SM00119	hect_3	coord: 747..1090 e-value: 1.1E-98 score: 343.8
IPR000569	HECT domain	PFAM	PF00632	HECT	coord: 785..1090 e-value: 5.5E-85 score: 285.5
IPR000569	HECT domain	PROSITE	PS50237	HECT	coord: 749..1090 score: 77.106
IPR000569	HECT domain	CDD	cd00078	HECTc	coord: 730..1087 e-value: 3.04184E-110 score: 345.319
IPR000048	IQ motif, EF-hand binding site	PROSITE	PS50096	IQ	coord: 44..73 score: 6.797
IPR035983	HECT, E3 ligase catalytic domain	SUPERFAMILY	SSF56204	Hect, E3 ligase catalytic domain	coord: 730..1082