SMED30013560

Overview
NameSMED30013560
Smed IDSMED30013560
Length (bp)1799
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30013560 (SMED30013560) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30013560 (SMED30013560) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30013560 (SMED30013560) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30013560 (SMED30013560) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30013560

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30013560SMESG000065648.1 SmedASXL_015585SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30013560SMESG000065648.1 dd_Smed_v4_15123_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30013560SMESG000065648.1 dd_Smed_v4_15123_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30013560SMESG000065648.1 dd_Smed_v4_15123_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Alignments
SMED30013560 aligns in the following genomic locations:
Alignment LocationAlignment Score
v31.003549:31448..33240 +8947
Homology
BLAST of SMED30013560 vs. Ensembl Human
Match: KPNA3 (karyopherin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6396])

HSP 1 Score: 80.1073 bits (196), Expect = 4.130e-15
Identity = 59/270 (21.85%), Postives = 117/270 (43.33%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   YNF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGG--TYNF 508          
BLAST of SMED30013560 vs. Ensembl Human
Match: KPNA7 (karyopherin subunit alpha 7 [Source:HGNC Symbol;Acc:HGNC:21839])

HSP 1 Score: 77.7962 bits (190), Expect = 2.074e-14
Identity = 55/234 (23.50%), Postives = 102/234 (43.59%), Query Frame = 2
Query:  719 DNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS---NYSEELCKIILECSVINAIEESNFH 1411
            D   K +L  L   L    +E   D  W+  Y+ + S   I  +++  ++   + L+     N   P  + +  +   +D    + +++ + + +P L   N     KE  + L+NVA+G    I+ L   ++L  ++  + NG ++VQ E ++   N A   + DQ++      V+     LL    ++   IILD + C L  +   +  E LC +I E   I+ IE    H
Sbjct:  236 DTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLH 469          
BLAST of SMED30013560 vs. Ensembl Human
Match: KPNA7 (karyopherin subunit alpha 7 [Source:HGNC Symbol;Acc:HGNC:21839])

HSP 1 Score: 77.7962 bits (190), Expect = 2.074e-14
Identity = 55/234 (23.50%), Postives = 102/234 (43.59%), Query Frame = 2
Query:  719 DNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS---NYSEELCKIILECSVINAIEESNFH 1411
            D   K +L  L   L    +E   D  W+  Y+ + S   I  +++  ++   + L+     N   P  + +  +   +D    + +++ + + +P L   N     KE  + L+NVA+G    I+ L   ++L  ++  + NG ++VQ E ++   N A   + DQ++      V+     LL    ++   IILD + C L  +   +  E LC +I E   I+ IE    H
Sbjct:  236 DTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLH 469          
BLAST of SMED30013560 vs. Ensembl Human
Match: KPNA4 (karyopherin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6397])

HSP 1 Score: 76.6406 bits (187), Expect = 4.720e-14
Identity = 56/269 (20.82%), Postives = 114/269 (42.38%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFN 509          
BLAST of SMED30013560 vs. Ensembl Human
Match: KPNA6 (karyopherin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6399])

HSP 1 Score: 60.4622 bits (145), Expect = 5.626e-9
Identity = 54/272 (19.85%), Postives = 110/272 (40.44%), Query Frame = 2
Query:  476 LLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISINEYKEHICKTVRNILNFK-VQRNDNITKDL------LKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELL 1270
            LLN+DF           + ++   +  L  I+  S    D++L C+I+N     P +++      +  T   +     + R  N   +       L +L++ LF S ++   D  W+  Y+ +     I  +ID  +    +ELL   +     P  + +  +    D    +IL  S   C+ +L         KE  + ++N+ +G+  +I+ + + NI   +I  +    +R + E  +   N     + +QI +  +   +   C+LL
Sbjct:  175 LLNSDF-----------EDVQEQAVWALGNIAGDSSVCRDYVLNCSILN-----PLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430          
BLAST of SMED30013560 vs. Ensembl Celegans
Match: ima-3 (Importin subunit alpha-3 [Source:UniProtKB/Swiss-Prot;Acc:Q19969])

HSP 1 Score: 60.8474 bits (146), Expect = 1.726e-9
Identity = 46/243 (18.93%), Postives = 106/243 (43.62%), Query Frame = 2
Query:  725 ITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            + + +L  L+  +        +D +W+  Y+ +    HI  +I+  ++ + + LL   +        + +  +   +D    ++L+S +   +P L         KE ++F++N+ +G+  +++ + +  I+  II+ +  G +  Q E  +   N+      +Q+       V+  FC +L     +   ++LD +   L +    +E++   I EC  ++ IE    H  +  YKL  + I
Sbjct:  232 VVRTILPALSLLIHHQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISGRPNQVEQMVKLGVLRPFCAMLSCTDSQIIQVVLDGINNILKMAGEAAEQVTSEIEECGGLDKIENLQNHENEDIYKLAFEII 474          
BLAST of SMED30013560 vs. Ensembl Celegans
Match: ima-2 (Importin subunit alpha-2 [Source:UniProtKB/Swiss-Prot;Acc:P91276])

HSP 1 Score: 58.9214 bits (141), Expect = 6.246e-9
Identity = 46/248 (18.55%), Postives = 114/248 (45.97%), Query Frame = 2
Query:  557 LTKISNHSEDSC---DFLLRCNIINFYSSIPDISINEYKEHICKTVRNILNFKVQRNDNITKDLLKILTKFLFD----SKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILE-SSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQ 1276
            L  ++N + DS    D++++C+ +     + +        H+        N    +N +   ++L++L+K L      +  + + D  W+  Y+ +     I+   +  ++ + +   + + EN   P  + +  V   +D+L   +++  SL   +P +    ++   KEC + ++N+ +G+  +I+ + + N+L  +I  + +G ++ Q E  +   N+A+  +  Q++     +VV   C+ L Q
Sbjct:  195 LWAVANIAGDSSQLRDYVIKCHGVEALMHLMEKVDQLGDSHVRTIAWAFSNMCRHKNPHAPLEVLRVLSKGLVKLVQHTDRQVRQDACWAVSYLTDGPDEQIELARESGVLPHVV-AFFKEAENLVAPALRTLGNVATGNDSLTQAVIDLGSLDEILPLMEKTRSSSIVKECCWLVSNIIAGTQKQIQAVLDANLLPVLINVLKSGDHKCQFEASWALSNLAQGGTNRQVVAMLEDNVVPALCQALLQ 441          
BLAST of SMED30013560 vs. Ensembl Fly
Match: Kap-alpha3 (gene:FBgn0027338 transcript:FBtr0301189)

HSP 1 Score: 69.707 bits (169), Expect = 3.122e-12
Identity = 61/290 (21.03%), Postives = 122/290 (42.07%), Query Frame = 2
Query:  593 DFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDNIT-KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            DF+++  ++    S   PDI I  +  ++   + N+   K       T  ++L  L   +  +     +D +W+  Y+ +     I  +I+  ++   I LL +          + +  +   SD    ++L     S  P L         KE ++FL+N+ +G+  +++ + N  +L  II ++  G ++ Q E  +   N+    + +Q+     + V+  FC+LL     +   ++LD L   L +  ++ E +   I EC  +  IE    H     YKL  + I
Sbjct:  188 DFVIKHGVVQPLLSFIKPDIPIT-FLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEII 476          
BLAST of SMED30013560 vs. Ensembl Fly
Match: Kap-alpha3 (gene:FBgn0027338 transcript:FBtr0082106)

HSP 1 Score: 69.707 bits (169), Expect = 3.122e-12
Identity = 61/290 (21.03%), Postives = 122/290 (42.07%), Query Frame = 2
Query:  593 DFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDNIT-KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            DF+++  ++    S   PDI I  +  ++   + N+   K       T  ++L  L   +  +     +D +W+  Y+ +     I  +I+  ++   I LL +          + +  +   SD    ++L     S  P L         KE ++FL+N+ +G+  +++ + N  +L  II ++  G ++ Q E  +   N+    + +Q+     + V+  FC+LL     +   ++LD L   L +  ++ E +   I EC  +  IE    H     YKL  + I
Sbjct:  188 DFVIKHGVVQPLLSFIKPDIPIT-FLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEII 476          
BLAST of SMED30013560 vs. Ensembl Fly
Match: Kap-alpha3 (gene:FBgn0027338 transcript:FBtr0082108)

HSP 1 Score: 69.707 bits (169), Expect = 3.122e-12
Identity = 61/290 (21.03%), Postives = 122/290 (42.07%), Query Frame = 2
Query:  593 DFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDNIT-KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            DF+++  ++    S   PDI I  +  ++   + N+   K       T  ++L  L   +  +     +D +W+  Y+ +     I  +I+  ++   I LL +          + +  +   SD    ++L     S  P L         KE ++FL+N+ +G+  +++ + N  +L  II ++  G ++ Q E  +   N+    + +Q+     + V+  FC+LL     +   ++LD L   L +  ++ E +   I EC  +  IE    H     YKL  + I
Sbjct:  188 DFVIKHGVVQPLLSFIKPDIPIT-FLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEII 476          
BLAST of SMED30013560 vs. Ensembl Fly
Match: Kap-alpha3 (gene:FBgn0027338 transcript:FBtr0082107)

HSP 1 Score: 69.707 bits (169), Expect = 3.122e-12
Identity = 61/290 (21.03%), Postives = 122/290 (42.07%), Query Frame = 2
Query:  593 DFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDNIT-KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            DF+++  ++    S   PDI I  +  ++   + N+   K       T  ++L  L   +  +     +D +W+  Y+ +     I  +I+  ++   I LL +          + +  +   SD    ++L     S  P L         KE ++FL+N+ +G+  +++ + N  +L  II ++  G ++ Q E  +   N+    + +Q+     + V+  FC+LL     +   ++LD L   L +  ++ E +   I EC  +  IE    H     YKL  + I
Sbjct:  188 DFVIKHGVVQPLLSFIKPDIPIT-FLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEII 476          
BLAST of SMED30013560 vs. Ensembl Fly
Match: Kap-alpha1 (gene:FBgn0024889 transcript:FBtr0074881)

HSP 1 Score: 52.373 bits (124), Expect = 9.060e-7
Identity = 38/177 (21.47%), Postives = 75/177 (42.37%), Query Frame = 2
Query:  740 LKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELL 1270
            L IL + L  + A+   D  W+  Y+ +     I  +ID  +    +ELL    +N +    + +  +    D    +IL  +  +CI +L         KE  + ++N+A+G+  +I+ L N NI   ++  +    ++ + E  +   N     + +QI +      V   C+ L
Sbjct:  267 LPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFL 443          
BLAST of SMED30013560 vs. Ensembl Zebrafish
Match: kpna4 (karyopherin alpha 4 (importin alpha 3) [Source:ZFIN;Acc:ZDB-GENE-030131-5584])

HSP 1 Score: 74.7146 bits (182), Expect = 1.091e-13
Identity = 56/269 (20.82%), Postives = 111/269 (41.26%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ Y + LL  +         + +  +   +D    ++L        P L         KE ++FL+N+ +G+  +++ + + N++  II  +  G +  Q E  +   N+      DQ+ +   + V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALGHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIILLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQQVIPPFCNLLTVKDAQVVQVVLDGLSNILKMADDEAETVANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDSNLVPEAIQGGTYSFN 509          
BLAST of SMED30013560 vs. Ensembl Zebrafish
Match: kpna3 (karyopherin alpha 3 (importin alpha 4) [Source:ZFIN;Acc:ZDB-GENE-030616-541])

HSP 1 Score: 73.559 bits (179), Expect = 2.832e-13
Identity = 56/270 (20.74%), Postives = 114/270 (42.22%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSN-YSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ Y + LL  +         + +  +   +D    ++L   + +    L         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI +   +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   +NF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLTHFSTLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGEEASTIAEIIEECGGLEKIENLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGG--TFNF 508          
BLAST of SMED30013560 vs. Ensembl Zebrafish
Match: kpna2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1) [Source:ZFIN;Acc:ZDB-GENE-040718-22])

HSP 1 Score: 70.0922 bits (170), Expect = 3.923e-12
Identity = 60/284 (21.13%), Postives = 120/284 (42.25%), Query Frame = 2
Query:  632 SIPDISI--NEYKEHICKTVRNILNFKVQRNDNIT------KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS---NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            ++PD+S+    Y  ++  T+ N+      RN N        K +L  L   L  S  E   D  W+  Y+ +     I+ +++  ++   ++LL     +   P  + I  +   +D     +LE+      P L     ++  KE  + L+N+ +G   +I+ + N  I+ +++  +  G Y+ Q E ++   N     + +Q+++    +V+     LL     +   +ILD +    +        E+LC +I EC  ++ IE    H  +  YK   + I
Sbjct:  211 AVPDLSVFPAGYLRNVTWTLSNLC-----RNKNPAPPLEAVKQILPTLICLLQHSDKEVLADTCWAISYLTDGPNDRIEVVVNAGVVPRLVQLLASGELSIVTPSLRSIGNIVTGTDEQTQAVLEAGALPMFPALLRHQKSNIQKEASWTLSNITAGRDYQIQEVINAGIVPYLVEVLRRGDYKTQKEAVWAVTNYTSGGTVEQVVYLVQANVLEPLLNLLSTKDSKTILVILDAITNIFLAGEKIGEVEKLCLMIEECGGLDKIEALQSHENEMVYKASLNLI 489          
BLAST of SMED30013560 vs. Ensembl Xenopus
Match: kpna3 (karyopherin alpha 3 (importin alpha 4) [Source:NCBI gene;Acc:548814])

HSP 1 Score: 74.7146 bits (182), Expect = 1.625e-13
Identity = 56/270 (20.74%), Postives = 117/270 (43.33%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILL--------EEKIPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S   NL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I            +  +PE   GG   Y+F
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFHNLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCSLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEALQQHENEEIYKLAFEIIDQYFSGDDIDEDQSLVPEATPGG--TYHF 508          
BLAST of SMED30013560 vs. Ensembl Xenopus
Match: kpna3 (karyopherin alpha 3 (importin alpha 4) [Source:NCBI gene;Acc:548814])

HSP 1 Score: 73.559 bits (179), Expect = 4.035e-13
Identity = 54/251 (21.51%), Postives = 109/251 (43.43%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILL--------EEKIPEIENGGNIVYNF 1513
            +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S   NL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I            +  +PE   GG   Y+F
Sbjct:  245 VDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFHNLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCSLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEALQQHENEEIYKLAFEIIDQYFSGDDIDEDQSLVPEATPGG--TYHF 493          
BLAST of SMED30013560 vs. Ensembl Xenopus
Match: kcnn1 (potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 [Source:Xenbase;Acc:XB-GENE-1001815])

HSP 1 Score: 73.1738 bits (178), Expect = 4.679e-13
Identity = 58/268 (21.64%), Postives = 115/268 (42.91%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNY-SEELCKIILECSVINAIEESNFHMTDCGYKLY----KDFISILLEEK---IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+   + LL +          + +  +   +D    ++L        P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L  ++  SE +  +I EC  +  IE+   H  +  YKL       F S  ++E    +PE   GG   +N
Sbjct:  237 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVTNLVPLLSNPEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALLHFPALLTHAKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDPQVIQVVLDGLSNILKMADEDSETIANLIEECGGLEKIEQLQSHENEDIYKLAFEIIDQFFSSDIDEDSNLVPETIQGGTFSFN 504          
BLAST of SMED30013560 vs. Ensembl Xenopus
Match: kpna3 (karyopherin alpha 3 (importin alpha 4) [Source:NCBI gene;Acc:548814])

HSP 1 Score: 73.1738 bits (178), Expect = 4.738e-13
Identity = 50/241 (20.75%), Postives = 108/241 (44.81%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S   NL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I
Sbjct:  223 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFHNLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCSLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEALQQHENEEIYKLAFEII 463          
BLAST of SMED30013560 vs. Ensembl Xenopus
Match: kcnn1 (potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 [Source:Xenbase;Acc:XB-GENE-1001815])

HSP 1 Score: 73.1738 bits (178), Expect = 5.068e-13
Identity = 58/268 (21.64%), Postives = 115/268 (42.91%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNY-SEELCKIILECSVINAIEESNFHMTDCGYKLY----KDFISILLEEK---IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+   + LL +          + +  +   +D    ++L        P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L  ++  SE +  +I EC  +  IE+   H  +  YKL       F S  ++E    +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVTNLVPLLSNPEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALLHFPALLTHAKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDPQVIQVVLDGLSNILKMADEDSETIANLIEECGGLEKIEQLQSHENEDIYKLAFEIIDQFFSSDIDEDSNLVPETIQGGTFSFN 508          
BLAST of SMED30013560 vs. Ensembl Mouse
Match: Kpna3 (karyopherin (importin) alpha 3 [Source:MGI Symbol;Acc:MGI:1100863])

HSP 1 Score: 80.1073 bits (196), Expect = 2.690e-15
Identity = 59/270 (21.85%), Postives = 117/270 (43.33%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   YNF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGG--TYNF 508          
BLAST of SMED30013560 vs. Ensembl Mouse
Match: Kpna4 (karyopherin (importin) alpha 4 [Source:MGI Symbol;Acc:MGI:1100848])

HSP 1 Score: 77.411 bits (189), Expect = 1.799e-14
Identity = 56/269 (20.82%), Postives = 114/269 (42.38%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDQAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGFN 509          
BLAST of SMED30013560 vs. Ensembl Mouse
Match: Kpna4 (karyopherin (importin) alpha 4 [Source:MGI Symbol;Acc:MGI:1100848])

HSP 1 Score: 75.8702 bits (185), Expect = 7.056e-14
Identity = 56/269 (20.82%), Postives = 114/269 (42.38%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  343 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDQAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGFN 611          
BLAST of SMED30013560 vs. Ensembl Mouse
Match: Kpna6 (karyopherin (importin) alpha 6 [Source:MGI Symbol;Acc:MGI:1100836])

HSP 1 Score: 60.8474 bits (146), Expect = 2.862e-9
Identity = 54/272 (19.85%), Postives = 111/272 (40.81%), Query Frame = 2
Query:  476 LLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISINEYKEHICKTVRNILNFK-VQRNDNITKDL------LKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELL 1270
            LLN+DF           + ++   +  L  I+  S    D++L C+I+N     P +++      +  T   +     + R  N   +       L +L++ LF S ++   D  W+  Y+ +     I  +ID  +    +ELL   +     P  + +  +    D    +IL  S   C+ +L   +     KE  + ++N+ +G+  +I+ + + NI   +I  +    +R + E  +   N     + +QI +  +   +   C+LL
Sbjct:  172 LLNSDF-----------EDVQEQAVWALGNIAGDSSLCRDYVLNCSILN-----PLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 427          
BLAST of SMED30013560 vs. Ensembl Mouse
Match: Kpna6 (karyopherin (importin) alpha 6 [Source:MGI Symbol;Acc:MGI:1100836])

HSP 1 Score: 60.8474 bits (146), Expect = 3.303e-9
Identity = 54/272 (19.85%), Postives = 111/272 (40.81%), Query Frame = 2
Query:  476 LLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISINEYKEHICKTVRNILNFK-VQRNDNITKDL------LKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELL 1270
            LLN+DF           + ++   +  L  I+  S    D++L C+I+N     P +++      +  T   +     + R  N   +       L +L++ LF S ++   D  W+  Y+ +     I  +ID  +    +ELL   +     P  + +  +    D    +IL  S   C+ +L   +     KE  + ++N+ +G+  +I+ + + NI   +I  +    +R + E  +   N     + +QI +  +   +   C+LL
Sbjct:  175 LLNSDF-----------EDVQEQAVWALGNIAGDSSLCRDYVLNCSILN-----PLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430          
BLAST of SMED30013560 vs. UniProt/SwissProt
Match: sp|O35344|IMA4_MOUSE (Importin subunit alpha-4 OS=Mus musculus OX=10090 GN=Kpna3 PE=1 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.881e-14
Identity = 59/270 (21.85%), Postives = 117/270 (43.33%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   YNF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGG--TYNF 508          
BLAST of SMED30013560 vs. UniProt/SwissProt
Match: sp|O00505|IMA4_HUMAN (Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2)

HSP 1 Score: 80.1073 bits (196), Expect = 1.983e-14
Identity = 59/270 (21.85%), Postives = 117/270 (43.33%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS-NYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI + + +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   YNF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGG--TYNF 508          
BLAST of SMED30013560 vs. UniProt/SwissProt
Match: sp|A9QM74|IMA8_HUMAN (Importin subunit alpha-8 OS=Homo sapiens OX=9606 GN=KPNA7 PE=1 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 9.961e-14
Identity = 55/234 (23.50%), Postives = 102/234 (43.59%), Query Frame = 2
Query:  719 DNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYS---NYSEELCKIILECSVINAIEESNFH 1411
            D   K +L  L   L    +E   D  W+  Y+ + S   I  +++  ++   + L+     N   P  + +  +   +D    + +++ + + +P L   N     KE  + L+NVA+G    I+ L   ++L  ++  + NG ++VQ E ++   N A   + DQ++      V+     LL    ++   IILD + C L  +   +  E LC +I E   I+ IE    H
Sbjct:  236 DTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLH 469          
BLAST of SMED30013560 vs. UniProt/SwissProt
Match: sp|O35343|IMA3_MOUSE (Importin subunit alpha-3 OS=Mus musculus OX=10090 GN=Kpna4 PE=1 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 1.258e-13
Identity = 56/269 (20.82%), Postives = 114/269 (42.38%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDQAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGFN 509          
BLAST of SMED30013560 vs. UniProt/SwissProt
Match: sp|O00629|IMA3_HUMAN (Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 2.267e-13
Identity = 56/269 (20.82%), Postives = 114/269 (42.38%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + + N++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFN 509          
BLAST of SMED30013560 vs. TrEMBL
Match: A0A183IG37 (Importin subunit alpha OS=Soboliphyme baturini OX=241478 GN=SBAD_LOCUS2581 PE=3 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 9.381e-14
Identity = 52/244 (21.31%), Postives = 114/244 (46.72%), Query Frame = 2
Query:  722 NITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            ++ + LL  L   + +      +D +W+  Y+ +     I  +ID ++++  + LL            + +  +   +D     +L+  +   +P+L         KE ++FL+N+ +G+S +++ + +  ++  IIY +  G ++ Q E  +   N+    + +Q+ +   + V+  FC+LL     +   ++LD L   L +  N SE++C++I EC  ++ IE    H  +  Y+   D I
Sbjct:  232 DVIQQLLPALCYLIHNEDVNILVDTVWALSYLTDSGNEQIQMVIDSNVVKDLVPLLGHPEVKVQTSSLRAVGNIVTGTDEQTQAVLDCGVLKYMPDLLTHPKEKLKKEAVWFLSNITAGNSSQVQAVIDAGLIPMIIYLLEKGEFQTQKEAAWAMSNVTISGTREQVAYMVQQGVIPPFCQLLGVSDTQVVHVVLDGLNNILKMAENESEQICRLIEECKGLDKIELLQTHENESIYRFAYDII 475          
BLAST of SMED30013560 vs. TrEMBL
Match: A0A1X7V0K0 (Importin subunit alpha OS=Amphimedon queenslandica OX=400682 GN=100634478 PE=3 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 1.033e-13
Identity = 70/331 (21.15%), Postives = 144/331 (43.50%), Query Frame = 2
Query:  491 FLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSS--IPDISINEYKEHICKTVRNILNFKVQRNDNIT------KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDT---LICALIYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            F+N++   +    +IR+  +  L  I+    +  DF++ C II    +   P +++N  + +I   + N+      RN N        + LL ILT+ +     E   D  W+  Y+ + S   I  +++  ++   +EL      +   P  + I  V   +D     +L          L   +  +  KE  + L+N+ +G  G+I+ + + N+L  +I  ++ G ++ Q E ++   N+    +  QI++     V+   C+LL     +   +ILD    ++ A   S  +E++C ++ +   ++ +E    H  D  Y+L  + I
Sbjct:  164 FINLLASPHA---NIRDQAVWALGNIAGDGSECRDFVIHCGIIQPLLACITPTVTVNHLR-NITWAISNLC-----RNKNPPPSMETIQQLLPILTQLINHQDKEVVSDACWALSYVTDGSTERIQTVVNSGVVPRLVELTGCGETSLASPSLRAIGNVVTGNDEQTQHVLNCGALQHFDPLLRHSRTNIQKEAAWTLSNITAGQQGQIQAVIDANLLPPLINILIKGEFKAQKEAVWAVTNLTAGGTVAQIMYALQMGVLKPLCDLLVVNDTKTILVILDAILNILNAAKKSGQAEQVCALMEDYEGLDKVEALQQHENDEVYQLSLNII 485          
BLAST of SMED30013560 vs. TrEMBL
Match: A0A1I7SM42 (Importin subunit alpha OS=Bursaphelenchus xylophilus OX=6326 PE=3 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 1.888e-13
Identity = 59/274 (21.53%), Postives = 127/274 (46.35%), Query Frame = 2
Query:  635 IPDISINEYKEHICKTVRNILNFK-VQRNDNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNY-SEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            +PDI +N +  ++   + N+   K    + +I + LL  L++ +        +D +W+  Y+ +     I  +ID  ++++ + LL            + +  +   +D    ++L++     +P L     +   KE ++FL+N+ +G+  +++ + + N++  II+ +  G ++ Q E  +   N+     ++ +L+     V+  FC LL     +   ++LD L   L  S   SEE+C+ I EC  ++ IE    H +   YK+  + I
Sbjct:  211 VPDIPLN-FLRNVTWVMVNLCRSKDPPPSRSIVESLLPALSQLIHHEDTSILVDTVWALSYLTDGGNDQIQMVIDSGVVQHLVPLLGHPEVKVQTAALRAVGNIVTGTDEQTQLVLDNGALQMMPALLSHVKDKINKEAVWFLSNITAGNEQQVQAVIDANLMPMIIHLLDRGDFQTQKEAAWAVSNVTISGKSEHVLYMVDCGVIVPFCNLLDIRDTQIVQVVLDGLNNILKKSQARSEEICQKIEECGGLDKIEHLQNHESQEIYKMAYEII 483          
BLAST of SMED30013560 vs. TrEMBL
Match: A0A5N5TKN5 (Importin subunit alpha-1 OS=Armadillidium nasatum OX=96803 GN=KPNA2 PE=4 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 3.961e-13
Identity = 93/486 (19.14%), Postives = 205/486 (42.18%), Query Frame = 2
Query:  122 QDFETIKNRMRNSSSILRRQKR---------YILNEEERQLE-----SFSSKQLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPI--FMYLNSH---KLSDVISCLNYLGDLIDESFGSISLLLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDN------ITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEEL---CKIILECSVINAIEESNFHMTDCGYK----LYKDFISILLEEKIP 1477
            +D E ++ R + +S  LR+QK+           L+E    L+     +   + LE+I+  I S+  +  + +     K +S+     I  +    +  P+  F+ L+S+   +     +  N      + +   ++      F+ +++  ++   ++    +  L  I+       DF+L   I+     +  PD   + +  ++  T+ N+      RN N      + K  L  +++ +     E + D  W+  Y+ +    +I +++D  ++ Y ++LL   +     P  + I  +   +D     ++ +   S +P L      +  KE  + ++NV +G+  +I+ + N +I+  +I  I+ G  + Q E  +   N     + +QI++   + V+  +C LL     +   ++LD +   L  +    EL   C++I EC  ++ IE    H  +  YK    + + F S   +E++P
Sbjct:   27 KDMEEMRRRRQETSVELRKQKKEDQLLKRRNVTLDEPTSPLQEQNAVALPCQSLEEIINGIASNDPHKQLQSTQAARKMLSRERTPPITAIIESGIVSPLVKFLALDSNPALQFEAAWALTNIASGTSEHTQAVVAAGGVGPFIRLLESSHV---NVAEQAVWALGNIAGDGAPLRDFVLSAGILQPLLKLIRPDTECS-FLRNVTWTLSNLC-----RNKNPSPPFEVIKHCLPAISRLIRHPDKEVRADACWALSYLTDGPNENIQEVVDTGVVPYLVQLLNTDDLTVVTPALRAIGNIVTGNDIQTDEVINAGALSILPKLLQHQKVNIMKEAAWAVSNVTAGNKEQIQAVINADIIKHLISVIIKGDLKSQREAAWAVTNFTSGGTPEQIVYLIKQGVLEPYCSLLDSNDTKMVMVVLDGISNILETAEKIHELDRMCQMIEECKALDKIEALQNHENNDVYKRALGIIERFFSEEEDEEVP 503          
BLAST of SMED30013560 vs. TrEMBL
Match: A0A444ST13 (Importin subunit alpha OS=Armadillidium vulgare OX=13347 GN=Avbf_08160 PE=3 SV=1)

HSP 1 Score: 83.1889 bits (204), Expect = 5.300e-13
Identity = 93/486 (19.14%), Postives = 205/486 (42.18%), Query Frame = 2
Query:  122 QDFETIKNRMRNSSSILRRQKR---------YILNEEERQLE-----SFSSKQLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPI--FMYLNSH---KLSDVISCLNYLGDLIDESFGSISLLLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRNDN------ITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEEL---CKIILECSVINAIEESNFHMTDCGYK----LYKDFISILLEEKIP 1477
            +D E ++ R + +S  LR+QK+           L+E    L+     +   + LE+I+  I S+  +  + +     K +S+     I  +    +  P+  F+ L+S+   +     +  N      + +   ++      F+ +++  ++   ++    +  L  I+       DF+L   I+     +  PD   + +  ++  T+ N+      RN N      + K  L  +++ +     E + D  W+  Y+ +    +I +++D  ++ Y ++LL   +     P  + I  +   +D     ++ +   S +P L      +  KE  + ++NV +G+  +I+ + N +I+  +I  I+ G  + Q E  +   N     + +QI++   + V+  +C LL     +   ++LD +   L  +    EL   C++I EC  ++ IE    H  +  YK    + + F S   +E++P
Sbjct:   27 KDMEEMRRRRQETSVELRKQKKEDQLLKRRNVTLDEPTSPLQEQNAVALPCQSLEEIINGIASNDPHKQLQSTQAARKMLSRERTPPITAIIESGIVSPLVQFLALDSNPALQFEAAWALTNIASGTSEHTQAVVASGGVGPFIRLLESPHV---NVAEQAVWALGNIAGDGAPLRDFVLSAGILQPLLKLIKPDTECS-FLRNVTWTLSNLC-----RNKNPSPPFEVIKHCLPAISRLIRHPDKEVRADACWALSYLTDGPNENIQEVVDTGVVPYLVQLLNTDDLTVVTPALRAIGNIVTGNDIQTDEVINAGALSILPKLLQHQKVNIMKEAAWAVSNVTAGNKEQIQAVINADIIKHLISVIIKGDLKSQREAAWAVTNFTSGGTPEQIVYLIKQGVLEPYCSLLDSNDTKMVMVVLDGISNILETAEKIHELDRMCQMIEECKALDKIEALQNHENNDVYKRALGIIERFFSEEEDEEVP 503          
BLAST of SMED30013560 vs. Ensembl Cavefish
Match: kpna3 (karyopherin subunit alpha 3 [Source:NCBI gene;Acc:103046682])

HSP 1 Score: 78.9518 bits (193), Expect = 4.623e-15
Identity = 58/270 (21.48%), Postives = 116/270 (42.96%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSN-YSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI +   +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   +NF
Sbjct:  241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGEEASTIAEIIEECGGLEKIENLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGG--TFNF 508          
BLAST of SMED30013560 vs. Ensembl Cavefish
Match: kpna3 (karyopherin subunit alpha 3 [Source:NCBI gene;Acc:103046682])

HSP 1 Score: 77.7962 bits (190), Expect = 1.079e-14
Identity = 56/251 (22.31%), Postives = 108/251 (43.03%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSN-YSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF 1513
            +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   + S  PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   LI +   +  + +II EC  +  IE    H  +  YKL  + I               IPE   GG   +NF
Sbjct:  261 VDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGEEASTIAEIIEECGGLEKIENLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGG--TFNF 509          
BLAST of SMED30013560 vs. Ensembl Cavefish
Match: KPNA3 (importin subunit alpha-4-like [Source:NCBI gene;Acc:103030092])

HSP 1 Score: 73.559 bits (179), Expect = 2.420e-13
Identity = 55/280 (19.64%), Postives = 118/280 (42.14%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSN-YSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYNF*FGLIIVNNF 1543
            +++L  L+  ++ +     +D +W+  Y+ +     I  +I+  ++ + + LL  +         + +  +   +D     +L   + S  P L     +   KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      +Q+ +   + VV   C+LL     +   ++LD L   L+ +   +  +  II EC  +  IE    H  +  YKL  + I               +PE   GG   +N   G +  N+F
Sbjct:  259 QEILPALSVLIYHTDINILVDTVWAVSYLTDGGNEQIQMVIESGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQAVLNCDVLSHFPLLLTHPKDKINKEAVWFLSNITAGNQQQVQAVIDAGLIPLIIHQLAKGDFGTQKEAAWAISNLTISGKKEQVEYLVQQGVVAPLCDLLVVRDAQVVQVVLDGLKNILLMAGEQASTVSNIIEECGGLEKIENLQQHENEYIYKLAFEIIDQYFSGDDIDEDLSLVPEAAQGGTFTFNP-PGDLQTNDF 537          
BLAST of SMED30013560 vs. Ensembl Cavefish
Match: kpna4 (karyopherin subunit alpha 4 [Source:NCBI gene;Acc:103046926])

HSP 1 Score: 73.1738 bits (178), Expect = 3.212e-13
Identity = 55/269 (20.45%), Postives = 111/269 (41.26%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L        P L         KE ++FL+N+ +G+  +++ + + N++  II  +  G +  Q E  +   N+      DQ+ +   + V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  IE+   H  +  YKL  + I               +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALGHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIILLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQQVIPPFCNLLTVKDAQVVQVVLDGLSNILKMADDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDSSLVPEAIQGGTYGFN 509          
BLAST of SMED30013560 vs. Ensembl Cavefish
Match: KPNA3 (importin subunit alpha-4-like [Source:NCBI gene;Acc:103030092])

HSP 1 Score: 72.7886 bits (177), Expect = 3.421e-13
Identity = 52/269 (19.33%), Postives = 113/269 (42.01%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSN-YSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEK--------IPEIENGGNIVYN 1510
            +++L  L+  ++ +     +D +W+  Y+ +     I  +I+  ++ + + LL  +         + +  +   +D     +L   + S  P L     +   KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      +Q+ +   + VV   C+LL     +   ++LD L   L+ +   +  +  II EC  +  IE    H  +  YKL  + I               +PE   GG   +N
Sbjct:  224 QEILPALSVLIYHTDINILVDTVWAVSYLTDGGNEQIQMVIESGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQAVLNCDVLSHFPLLLTHPKDKINKEAVWFLSNITAGNQQQVQAVIDAGLIPLIIHQLAKGDFGTQKEAAWAISNLTISGKKEQVEYLVQQGVVAPLCDLLVVRDAQVVQVVLDGLKNILLMAGEQASTVSNIIEECGGLEKIENLQQHENEYIYKLAFEIIDQYFSGDDIDEDLSLVPEAAQGGTFTFN 492          
BLAST of SMED30013560 vs. Ensembl Sea Lamprey
Match: kpna4 (karyopherin alpha 4 (importin alpha 3) [Source:ZFIN;Acc:ZDB-GENE-030131-5584])

HSP 1 Score: 72.7886 bits (177), Expect = 7.418e-14
Identity = 48/222 (21.62%), Postives = 96/222 (43.24%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            +D +W+  Y+ +     I  +ID  ++ Y + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ +   ++V+  FC LL     +   ++LD L   L +     E +  +I EC  +  IE    H  +  YKL  + I
Sbjct:  263 VDTVWALSYLTDGGNEQIQMVIDSGVVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHAKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHHLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVRENVIPPFCALLAVKDPQVVQVVLDGLNNILKMAGEEVETIASVIEECGGLEKIEALQQHENEDIYKLAYEII 484          
BLAST of SMED30013560 vs. Ensembl Nematostella
Match: EDO29161 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4F4])

HSP 1 Score: 59.3066 bits (142), Expect = 1.665e-9
Identity = 43/222 (19.37%), Postives = 96/222 (43.24%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI 1450
            +D +W+  Y+ +  +  I  +I+  +++Y + LL  +         + +  +   +D    ++L     S    L   +     KE ++FL+N+ +G+  +++ + +  ++  II ++  G ++ Q E  +   N+      +Q+      + V   C+LL     +   I+LD L   L +  + +  +   I E   ++ IE    H  +  YKL  + I
Sbjct:  149 VDTVWALSYLTDGGSHQIQLVIESGVVQYLVPLLSHQEIKLQTAALRAVGNIVTGTDEQTQVVLNHGALSHFTGLLTHHKEKIKKEAVWFLSNITAGNQSQVQEVIDAGLIPLIIQTLETGEFQTQKEAAWAISNMTVSGRREQVAVLVHCNAVEHLCKLLDVRDTQVVQIVLDGLNNILKMAGDKATVIATAIEEAGGLDKIELLQHHQNEEIYKLAFEMI 370          
BLAST of SMED30013560 vs. Ensembl Nematostella
Match: EDO38337 (Importin subunit alpha [Source:UniProtKB/TrEMBL;Acc:A7SD78])

HSP 1 Score: 57.7658 bits (138), Expect = 8.564e-9
Identity = 55/260 (21.15%), Postives = 113/260 (43.46%), Query Frame = 2
Query:  503 IKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISIN-EYKEHICKTVRNILNFKVQRND-NITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNEN--FNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELL 1270
            IK L    + ++   +  L  I+  S D  D++L C ++  + ++   S       ++   + N+   +    D       L +L++ LF + AE   D  W+  Y+L+     I  +ID  +    +ELL D N+N   +  +  + N V  D D    +IL       + +L         KE  + ++N+ +G+  +I+ + + NI+  +I  +    ++ + E  +   N     +A+QI +  ++  +   C+LL
Sbjct:  165 IKLLESPKEEVQEQAVWALGNIAGDSADCRDYVLNCGVLTPFLNLLTKSTRLSMTRNLVWALSNLCRGRHPPPDFAKVSPCLPLLSRLLFSTDAEVLADTCWALSYLLDGPNEKIQAVIDSGVCRRLVELL-DHNQNSVVSAALRAVGNIVTGD-DIQTQVILNCHALPNLLHLLSSTKESIRKEACWTISNITAGNRLQIQAVIDANIIPMLIDVLNKAEFKTRKEAAWAIANATSGGTAEQIRYIVSQGAIRPLCDLL 422          
BLAST of SMED30013560 vs. Ensembl Nematostella
Match: EDO30648 (Importin subunit alpha [Source:UniProtKB/TrEMBL;Acc:A7T055])

HSP 1 Score: 55.8398 bits (133), Expect = 2.875e-8
Identity = 67/347 (19.31%), Postives = 143/347 (41.21%), Query Frame = 2
Query:  374 PIFMYLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDFLNIIKKLYIFDDSIRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSI--PDISINEYKEHICKTVRNILNFKVQRND-NITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQII-NFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEELCKIILECSVINAIEES 1402
            P+  +  +  L+++ S  +     + E  G++ +         +K L    D++    +  L  I+       + ++ C  +    ++  P  SI ++  ++  T+ N+   K    D    + +L  + + +     E   D  W+  Y+ +     I  ++D  ++   +ELL     N   P  + I N V    D  + +I   +LF     L     ++  KE  + ++NV +G++ +I+ + +  ++  I+  +  G ++ + E I+   N     + DQ+ +    DV+   CE LK    +   I+LD L   L  ++  E +         ++ IEES
Sbjct:  128 PLLQFEAAWALTNIASGTSEQTKAVQEG-GAVPMF--------VKLLSSVHDNVAEQAVWALGNIAGDGPLMRNTVIACGALGPLLALIKPSTSI-QFLRNVTWTLSNLCRNKNPPPDVTAVQQVLPAIARLILSDDKEVLADTCWALSYLTDGVNERIQLVLDSGVVPKLVELLGYPEVNVLTPALRAIGNIVTGRDDQTQAVIDTGALF-YFRALLTHKKSNIIKEAAWAISNVTAGTAQQIQAVMDSGLVPLIVDILRRGDFKARKEAIWVITNYCSGANPDQVKYLLHCDVIPPLCEQLKIQDQKDIQILLDGLKSLLASASKIEGMLD-----DTLDKIEES 458          
BLAST of SMED30013560 vs. Ensembl Medaka
Match: kpna3 (karyopherin subunit alpha 3 [Source:NCBI gene;Acc:101166015])

HSP 1 Score: 80.4925 bits (197), Expect = 1.640e-15
Identity = 60/270 (22.22%), Postives = 118/270 (43.70%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNY-SEELCKIILECSVINAIEESNFHMTDCGYKLYKDFI------SILLEEK--IPEIENGGNIVYNF 1513
            +++L  L   ++ +     +D +W+  Y+ +     I  +ID  ++ + + LL  +         + +  +   +D    ++L   +    PNL         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+ F    +V+  FC LL     +   ++LD L   LI +   +  + +II EC  +  IE+   H  +  YKL  + I       I  E+   IPE   GG   +NF
Sbjct:  241 QEILPALCMLIYHTDLNILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLLHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEFLVEHNVIPPFCSLLSVKDSQVVQVVLDGLKNILIMAGQEASTIAEIIEECGGLEKIEQLQQHENEDIYKLAFEIIDQYFSGDIFDEDPNLIPETTQGG--TFNF 508          
BLAST of SMED30013560 vs. Ensembl Medaka
Match: kpna4 (karyopherin subunit alpha 4 [Source:NCBI gene;Acc:101173644])

HSP 1 Score: 73.559 bits (179), Expect = 2.263e-13
Identity = 57/269 (21.19%), Postives = 115/269 (42.75%), Query Frame = 2
Query:  731 KDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICAL-IYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKD-----FISILLEEK---IPEIENGGNIVYN 1510
            +++L  L   +  +     +D +W+  Y+ +     I  +ID  I+ + + LL  +         + +  +   +D    ++L     S  P L         KE ++FL+N+ +G+  +++ + +  ++  II+ +  G +  Q E  +   N+      DQ+     K V+  FC LL     +   ++LD L   L +  + +E +  +I EC  +  +E+   H  +  YKL  +     F S  ++E    +PE   GG   +N
Sbjct:  241 QEILPALCVLIHHTDVSILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAKLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAHLIEKQVIPPFCNLLTVKDAQVVQVVLDGLSNILKMADDEAETIANLIEECGGLEKVEQLQNHENEDIYKLAYEIIDQYFSSDDIDEDTSLVPETIQGGTYGFN 509          
BLAST of SMED30013560 vs. Planmine SMEST
Match: SMESG000065648.1 (SMESG000065648.1)

HSP 1 Score: 269.24 bits (687), Expect = 5.341e-88
Identity = 136/136 (100.00%), Postives = 136/136 (100.00%), Query Frame = 2
Query:   86 MKNNYRENKPNKQDFETIKNRMRNSSSILRRQKRYILNEEERQLESFSSKQLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPIFMYLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDF 493
            MKNNYRENKPNKQDFETIKNRMRNSSSILRRQKRYILNEEERQLESFSSKQLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPIFMYLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDF
Sbjct:    1 MKNNYRENKPNKQDFETIKNRMRNSSSILRRQKRYILNEEERQLESFSSKQLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPIFMYLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDF 136          
BLAST of SMED30013560 vs. Planmine SMEST
Match: SMESG000065630.1 (SMESG000065630.1)

HSP 1 Score: 146.747 bits (369), Expect = 7.728e-38
Identity = 122/464 (26.29%), Postives = 233/464 (50.22%), Query Frame = 2
Query:  101 RENKPNKQDFETIKNRMRNSSSILRRQKRYILNEEERQLESFSSKQLEDILCNIYSHLVNND---VINAILLMKRVSKSVENGIDILYNRNLFQPIFMYLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDFLNIIKKLYIFDDS-IRNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISIN----EYKEHICKTVRNILNFKVQRNDNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEELCKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEE 1468
            R+ K   +  + +++RMR +S  +R   +    +  R           + +  +   L + D   V  AI++M   SKS ENGI+ L    +F      + + ++  V+  +  L ++I+ES+G+I  LLN+ F NI+K L    +  I +  + L+++I++HS D+C  ++  N+I F S +   S+N    ++ + +C  ++NI N   ++      +LL I  +   +   E K  I W+ +++LE+  +  +   +       +E+   +     LPI +II   Y +       IL   +   I N    N  D WKE + FL N+A+     + ++ + NI+  I  S++N   ++Q++ +    NI K  S D+I FW TK+++ +FC++L     E +  +LD LI   I     + +  I+ + +++++IE++ F+MTD G++LY ++I  L +E
Sbjct:    3 RKWKGKNRTIDQVRDRMRTNSFQIRINNQIHFKDNMRNTGFIDLVPSSEEIMKLKFCLSSGDLKLVKEAIIVMINFSKSNENGIEFLLVNGIFDIYLNNIENFEIESVVFYITNLSNIIEESWGNILSLLNDRFYNILKNLLSNPNQLILSPTLELISRITSHSNDACCSVIDFNLIEFLSRM---SLNSCFIDFDQSVCDILKNICNAGYEKLLPSFDELLLITKRIFINCSLERKGVIAWAIVFLLEDCDVAYEIFDNNVTC-CTLEIFNKRISKAYLPILKIIYLEYCNGRKFSNEILSRGILENIDNSVTVNR-DTWKESLLFLINIANEYPECVSIMTSKNIVDLIELSLLNENPKIQEDALLLLNNITKSASKDEINFWITKEILSIFCDILSMKIDELSAAVLDLLINVAISHRNDDVIMDILRQSNILDSIEKAGFNMTDRGFRLYDEYIRYLNDE 461          
BLAST of SMED30013560 vs. Planmine SMEST
Match: SMESG000058125.1 (SMESG000058125.1)

HSP 1 Score: 80.4925 bits (197), Expect = 9.458e-16
Identity = 52/235 (22.13%), Postives = 108/235 (45.96%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEEL-CKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEKIPEIEN 1489
            +D +W+  Y+ +     I  +I+  I+ + + LL   +        + +  +   +D     +L     S  P L   +     KE ++FL+N+ +G+  +++ + + +++  IIY +  G ++ Q E  +   N+    +  Q+ F   + V+  FC++L     +   ++LD ++  L  +N   +L C +I EC  ++ IE+   H     YKL  D I     +++ E EN
Sbjct:  250 VDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNIVTGTDEQTQYVLNFDALSHFPQLLQHSKEKINKEAVWFLSNITAGNQEQVQAVIDYSLIPLIIYHLDKGDFQTQKEAAWVISNLTISGTPQQVAFVVQQGVIPPFCKMLSVRDAQVVQVVLDGILNILKVANDQSDLVCTMIEECGGLDLIEQLQHHENGEIYKLAYDIIDNFFNDEMEETEN 484          
BLAST of SMED30013560 vs. Planmine SMEST
Match: SMESG000058125.1 (SMESG000058125.1)

HSP 1 Score: 80.4925 bits (197), Expect = 9.955e-16
Identity = 52/235 (22.13%), Postives = 108/235 (45.96%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEEL-CKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEKIPEIEN 1489
            +D +W+  Y+ +     I  +I+  I+ + + LL   +        + +  +   +D     +L     S  P L   +     KE ++FL+N+ +G+  +++ + + +++  IIY +  G ++ Q E  +   N+    +  Q+ F   + V+  FC++L     +   ++LD ++  L  +N   +L C +I EC  ++ IE+   H     YKL  D I     +++ E EN
Sbjct:  244 VDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNIVTGTDEQTQYVLNFDALSHFPQLLQHSKEKINKEAVWFLSNITAGNQEQVQAVIDYSLIPLIIYHLDKGDFQTQKEAAWVISNLTISGTPQQVAFVVQQGVIPPFCKMLSVRDAQVVQVVLDGILNILKVANDQSDLVCTMIEECGGLDLIEQLQHHENGEIYKLAYDIIDNFFNDEMEETEN 478          
BLAST of SMED30013560 vs. Planmine SMEST
Match: SMESG000058125.1 (SMESG000058125.1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.284e-15
Identity = 52/235 (22.13%), Postives = 108/235 (45.96%), Query Frame = 2
Query:  788 LDIIWSFLYILEESAXXXXXXXXXXXXEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILESSLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIYSIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSIERNCIILDTLICALIYSNYSEEL-CKIILECSVINAIEESNFHMTDCGYKLYKDFISILLEEKIPEIEN 1489
            +D +W+  Y+ +     I  +I+  I+ + + LL   +        + +  +   +D     +L     S  P L   +     KE ++FL+N+ +G+  +++ + + +++  IIY +  G ++ Q E  +   N+    +  Q+ F   + V+  FC++L     +   ++LD ++  L  +N   +L C +I EC  ++ IE+   H     YKL  D I     +++ E EN
Sbjct:  233 VDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNIVTGTDEQTQYVLNFDALSHFPQLLQHSKEKINKEAVWFLSNITAGNQEQVQAVIDYSLIPLIIYHLDKGDFQTQKEAAWVISNLTISGTPQQVAFVVQQGVIPPFCKMLSVRDAQVVQVVLDGILNILKVANDQSDLVCTMIEECGGLDLIEQLQHHENGEIYKLAYDIIDNFFNDEMEETEN 467          
The following BLAST results are available for this feature:
BLAST of SMED30013560 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
KPNA34.130e-1521.85karyopherin subunit alpha 3 [Source:HGNC Symbol;Ac... [more]
KPNA72.074e-1423.50karyopherin subunit alpha 7 [Source:HGNC Symbol;Ac... [more]
KPNA72.074e-1423.50karyopherin subunit alpha 7 [Source:HGNC Symbol;Ac... [more]
KPNA44.720e-1420.82karyopherin subunit alpha 4 [Source:HGNC Symbol;Ac... [more]
KPNA65.626e-919.85karyopherin subunit alpha 6 [Source:HGNC Symbol;Ac... [more]
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BLAST of SMED30013560 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ima-31.726e-918.93Importin subunit alpha-3 [Source:UniProtKB/Swiss-... [more]
ima-26.246e-918.55Importin subunit alpha-2 [Source:UniProtKB/Swiss-... [more]
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BLAST of SMED30013560 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Kap-alpha33.122e-1221.03gene:FBgn0027338 transcript:FBtr0301189[more]
Kap-alpha33.122e-1221.03gene:FBgn0027338 transcript:FBtr0082106[more]
Kap-alpha33.122e-1221.03gene:FBgn0027338 transcript:FBtr0082108[more]
Kap-alpha33.122e-1221.03gene:FBgn0027338 transcript:FBtr0082107[more]
Kap-alpha19.060e-721.47gene:FBgn0024889 transcript:FBtr0074881[more]
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BLAST of SMED30013560 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
kpna41.091e-1320.82karyopherin alpha 4 (importin alpha 3) [Source:ZFI... [more]
kpna32.832e-1320.74karyopherin alpha 3 (importin alpha 4) [Source:ZFI... [more]
kpna23.923e-1221.13karyopherin alpha 2 (RAG cohort 1, importin alpha ... [more]
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BLAST of SMED30013560 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
kpna31.625e-1320.74karyopherin alpha 3 (importin alpha 4) [Source:NCB... [more]
kpna34.035e-1321.51karyopherin alpha 3 (importin alpha 4) [Source:NCB... [more]
kcnn14.679e-1321.64potassium channel, calcium activated intermediate/... [more]
kpna34.738e-1320.75karyopherin alpha 3 (importin alpha 4) [Source:NCB... [more]
kcnn15.068e-1321.64potassium channel, calcium activated intermediate/... [more]
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BLAST of SMED30013560 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Kpna32.690e-1521.85karyopherin (importin) alpha 3 [Source:MGI Symbol;... [more]
Kpna41.799e-1420.82karyopherin (importin) alpha 4 [Source:MGI Symbol;... [more]
Kpna47.056e-1420.82karyopherin (importin) alpha 4 [Source:MGI Symbol;... [more]
Kpna62.862e-919.85karyopherin (importin) alpha 6 [Source:MGI Symbol;... [more]
Kpna63.303e-919.85karyopherin (importin) alpha 6 [Source:MGI Symbol;... [more]
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BLAST of SMED30013560 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O35344|IMA4_MOUSE1.881e-1421.85Importin subunit alpha-4 OS=Mus musculus OX=10090 ... [more]
sp|O00505|IMA4_HUMAN1.983e-1421.85Importin subunit alpha-4 OS=Homo sapiens OX=9606 G... [more]
sp|A9QM74|IMA8_HUMAN9.961e-1423.50Importin subunit alpha-8 OS=Homo sapiens OX=9606 G... [more]
sp|O35343|IMA3_MOUSE1.258e-1320.82Importin subunit alpha-3 OS=Mus musculus OX=10090 ... [more]
sp|O00629|IMA3_HUMAN2.267e-1320.82Importin subunit alpha-3 OS=Homo sapiens OX=9606 G... [more]
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BLAST of SMED30013560 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183IG379.381e-1421.31Importin subunit alpha OS=Soboliphyme baturini OX=... [more]
A0A1X7V0K01.033e-1321.15Importin subunit alpha OS=Amphimedon queenslandica... [more]
A0A1I7SM421.888e-1321.53Importin subunit alpha OS=Bursaphelenchus xylophil... [more]
A0A5N5TKN53.961e-1319.14Importin subunit alpha-1 OS=Armadillidium nasatum ... [more]
A0A444ST135.300e-1319.14Importin subunit alpha OS=Armadillidium vulgare OX... [more]
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BLAST of SMED30013560 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
kpna34.623e-1521.48karyopherin subunit alpha 3 [Source:NCBI gene;Acc:... [more]
kpna31.079e-1422.31karyopherin subunit alpha 3 [Source:NCBI gene;Acc:... [more]
KPNA32.420e-1319.64importin subunit alpha-4-like [Source:NCBI gene;Ac... [more]
kpna43.212e-1320.45karyopherin subunit alpha 4 [Source:NCBI gene;Acc:... [more]
KPNA33.421e-1319.33importin subunit alpha-4-like [Source:NCBI gene;Ac... [more]
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BLAST of SMED30013560 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
kpna47.418e-1421.62karyopherin alpha 4 (importin alpha 3) [Source:ZFI... [more]
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BLAST of SMED30013560 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30013560 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO291611.665e-919.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO383378.564e-921.15Importin subunit alpha [Source:UniProtKB/TrEMBL;A... [more]
EDO306482.875e-819.31Importin subunit alpha [Source:UniProtKB/TrEMBL;A... [more]
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BLAST of SMED30013560 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
kpna31.640e-1522.22karyopherin subunit alpha 3 [Source:NCBI gene;Acc:... [more]
kpna42.263e-1321.19karyopherin subunit alpha 4 [Source:NCBI gene;Acc:... [more]
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BLAST of SMED30013560 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000065648.15.341e-88100.00SMESG000065648.1[more]
SMESG000065630.17.728e-3826.29SMESG000065630.1[more]
SMESG000058125.19.458e-1622.13SMESG000058125.1[more]
SMESG000058125.19.955e-1622.13SMESG000058125.1[more]
SMESG000058125.11.284e-1522.13SMESG000058125.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013560 ID=SMED30013560|Name=SMED30013560|organism=Schmidtea mediterranea sexual|type=transcript|length=1799bp
CTTCAACAAAATAATAATTTGAAATTCGTATTTATATATCCCATTTTGTT
TAAATATTATTGTTTTCTTGAAAATTTTATCGATTATGAAAAATAATTAT
CGTGAAAATAAGCCAAATAAACAGGATTTTGAAACTATTAAAAATCGAAT
GAGAAATAGTAGTTCTATTTTAAGGAGACAAAAACGTTATATACTTAACG
AAGAAGAACGCCAATTAGAAAGCTTTAGCAGTAAACAATTAGAAGATATC
TTATGTAACATTTATTCTCACCTAGTCAATAATGACGTAATAAATGCTAT
TTTATTAATGAAACGTGTTTCAAAATCAGTTGAAAACGGCATAGATATTT
TGTACAACAGAAATTTATTTCAACCTATATTTATGTATCTGAATTCACAT
AAATTATCCGATGTAATAAGCTGTCTCAATTATTTAGGCGATTTAATCGA
CGAGTCTTTCGGTTCCATATCTTTATTATTGAATAATGATTTTTTGAATA
TTATCAAAAAACTATATATTTTTGATGATTCAATTAGAAATGGAGTTATA
ATATTATTAACTAAAATTTCTAATCACAGTGAAGACTCGTGTGACTTTCT
CCTACGATGCAATATAATTAATTTCTACTCGTCAATCCCTGATATTTCTA
TCAATGAATATAAAGAACATATTTGTAAAACTGTTAGAAATATTCTAAAT
TTTAAAGTACAAAGAAATGATAACATTACAAAAGATTTGTTGAAAATACT
GACCAAATTTCTCTTCGATTCAAAAGCTGAATGTAAATTAGATATTATAT
GGAGTTTTTTATATATCTTGGAAGAAAGTGCGATTCATATTGATGATATT
ATTGATAAATCAATAATAGAATATTTTATTGAATTGTTATGGGATAAAAA
TGAAAATTTCAATTTACCTATTTTCCAAATTATTAATTTTGTCTATCTTG
ATAGCGATACATTGAAAACCATTATTTTGGAAAGCTCTTTATTTTCATGT
ATTCCTAATTTATTCCCATTTAACAATAATGATTATTGGAAAGAGTGCAT
TTTTTTCCTTACAAATGTCGCATCGGGAAGCTCTGGTGAAATAGAAGTAT
TAAAAAATTGTAATATATTATCCTTTATAATTTATTCTATCGTAAATGGT
ATTTATCGAGTTCAAGATGAAACGATTTATTTCTTCAGAAACATTGCAAA
AAAGGAATCTGCTGATCAAATATTATTTTGGTTTACAAAAGATGTAGTGT
TTTTATTTTGTGAGTTATTGAAGCAAGGAAGTATAGAAAGAAATTGTATT
ATTTTGGATACTTTAATATGTGCTTTAATTTATTCAAATTATTCCGAAGA
ATTATGTAAAATAATTCTCGAATGTAGTGTTATAAATGCCATTGAGGAGT
CTAATTTTCACATGACCGATTGTGGTTACAAATTGTACAAGGATTTTATT
TCCATTTTATTAGAGGAAAAAATTCCCGAAATTGAAAATGGCGGAAATAT
TGTTTATAATTTTTAATTTGGGTTAATTATAGTAAATAATTTTAGTAAAT
AATTATTACATTAAATTTATATCTCTTTACCGACACTAAATTTGCATTTT
ATTGAAATCAGTTTGTATATAAATTTTTGTTTTAAATTTTGAGTATTTGG
CATTTAGTTGATTTATGAATGTTTTATGTTAATAGTGGATTTTTATCGCT
TTAAGGATTCTTTCATTTTGCAATTATATATCGTTGTTTTGTTATAAAAA
TTAAGTTAATAGGTTTTTATTGAAATTAAAATGTGAAAGTGTAAAAAAA
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protein sequence of SMED30013560-orf-1

>SMED30013560-orf-1 ID=SMED30013560-orf-1|Name=SMED30013560-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=477bp
MKNNYRENKPNKQDFETIKNRMRNSSSILRRQKRYILNEEERQLESFSSK
QLEDILCNIYSHLVNNDVINAILLMKRVSKSVENGIDILYNRNLFQPIFM
YLNSHKLSDVISCLNYLGDLIDESFGSISLLLNNDFLNIIKKLYIFDDSI
RNGVIILLTKISNHSEDSCDFLLRCNIINFYSSIPDISINEYKEHICKTV
RNILNFKVQRNDNITKDLLKILTKFLFDSKAECKLDIIWSFLYILEESAI
HIDDIIDKSIIEYFIELLWDKNENFNLPIFQIINFVYLDSDTLKTIILES
SLFSCIPNLFPFNNNDYWKECIFFLTNVASGSSGEIEVLKNCNILSFIIY
SIVNGIYRVQDETIYFFRNIAKKESADQILFWFTKDVVFLFCELLKQGSI
ERNCIILDTLICALIYSNYSEELCKIILECSVINAIEESNFHMTDCGYKL
YKDFISILLEEKIPEIENGGNIVYNF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR011989ARM-like
IPR016024ARM-type_fold
Vocabulary: molecular function
TermDefinition
GO:0005488binding
GO:0008565protein transporter activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0006606protein import into nucleus
GO:0006810transport
GO:0015031protein transport