TIR domain-containing protein

Overview
NameTIR domain-containing protein
Smed IDSMED30013530
Length (bp)1900
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TIR domain-containing protein (SMED30013530) t-SNE clustered cells

Violin plots show distribution of expression levels for TIR domain-containing protein (SMED30013530) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TIR domain-containing protein (SMED30013530) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TIR domain-containing protein (SMED30013530) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013530

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30013530h1SMcG0016555 SmedASXL_019697SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30013530h1SMcG0016555 Contig49415newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30013530h1SMcG0016555 Contig49415uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30013530h1SMcG0016555 dd_Smed_v4_4452_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30013530h1SMcG0016555 dd_Smed_v4_4452_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: W4XMC6 (TIR domain-containing protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1)

HSP 1 Score: 193.741 bits (491), Expect = 6.457e-51
Identity = 129/450 (28.67%), Postives = 232/450 (51.56%), Query Frame = 3 
Query:  525 ITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDEN--EINLFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLES--LPKGNTEKTAIVFDA-------FMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSN-----SRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKM-NFIEVVKFHKALNDLI 1823
            + I+HN A    +K  YR +++ ++      L  D Y   +S++TL+Y+++E   EI    G   I   +       N    R +G +V+E+   L RL+ +D  K  I    G+ ++I +L+  + E   E +   +  L F++D+  KL ++      L   +  S++++ +  NG LW+++ + E   L K N + T +            +SY W  +  VL++  +L     N+W+D + M  STL+AMA  IEN+  +V+  S  YK S NCR EAEYA +++K IIP++ME  Y+P  WLGI+ G K Y++FS R +  E++ +L+K ++ H +   K+  K D + G    ++         I +  E  +WS   V DWL +  + +L+      +G ++  +  +R  + D+F   +K +F +   I++++F +AL+ L+
Sbjct:   39 LNILHNLAKAPGNKHVYREEKVVESMEPF--LEGDPYLKAVSMMTLAYIVEEGQEEILAEKGTNTIEYLVEILKDAQNSKDKRCQGLSVEEVTAALGRLAVHDNNKYKIVEAGGLPLMISMLHDESVETQ-EASAHAVWNLAFSDDVSEKLRSNTDCMMALQDLSTSSSSEVAKAANGALWVINKEGEKKDLVKENEDDTGLGHSLSRKQPHIMLSYQWGCQPLVLKMRDVLAKAGYNIWVDVDCMYGSTLQAMAEAIENACAIVMCMSERYKESPNCRTEAEYAFQLRKRIIPVMMEEYYQPDGWLGIILGAKFYMDFSGRLDIEEEMNKLLKEVQMH-SAEAKIIYKDDTDDGVLVGASISFPLESAGISIKMESLDWSASQVQDWLIENELEHLRPLMAEYNGKLLNQLYKMRQEAPDFFYLSIKEDFGLKKLIDILRFTEALDSLL 484
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A210QF19 (Vacuolar protein 8 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT22612 PE=4 SV=1)

HSP 1 Score: 183.341 bits (464), Expect = 1.195e-45
Identity = 136/457 (29.76%), Postives = 235/457 (51.42%), Query Frame = 3 
Query:  501 ENKNF----KSLITIIHNFASHKLDKINY-RVDEIKKTFLDIV-NLNCDDYYGLISLVTLSYLIDENEIN-LFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWIL--DNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIK--FHLNRPVKLAEKIDLNAGEKNRSNSRTRI------VLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDL 1820
            +NKN     KS ++IIHN A +  D I++ + ++     L  V +    +   +++++TLS++++E E + L D   +I   +    K I + + R  GFT +EL+ GL +L+ ND  K  I     + V + +L S + E     T   I  L F+ ++  K++ H  +  +L K    S++ + ++ NG L++L  +N +   P+   +    VF   +SYSW  K+ VL+I   LK+  V VWID E M  STL AMA  +EN+ VV++  S  YK S NCRLEAEY  +++K  IPL+M+ KY+P  WLG + G K+Y +FS +    +    L K ++    L+ P     K D+  G    +++ T                 + E+VG+WL +  +          DG ++  +  +++ + +++   L+ +  MN +E++ F +AL+ L
Sbjct:  258 DNKNVYYIVKSSMSIIHNIARNP-DVIHFFKENKTTDVMLKFVRSYEEHEMLKIMAMLTLSHIVEEEENDKLMDDTGSIEGTIKYIDKAIEDERRRYRGFTPQELMDGLGKLAVNDNNKKKIVEAGALPVFMKMLKSDSAEEQTV-TARAIWTLSFDKEVSQKIVEHPDMMTSLEKLRESSDSDVRKNVNGALFVLKGENDVSRRPRSGKKNKGHVF---ISYSWNEKEIVLKIRERLKAEGVEVWIDIERMGGSTLTAMAEAVENAAVVLLCMSEKYKQSPNCRLEAEYTFQLRKDYIPLMMQKKYRPDGWLGAILGAKLYFDFSGKYPFEKPWNGLQKELRGIGRLSTPSATPGK-DVTDGPIMATSACTAASSPGSLSTSSHAHKMTTEDVGNWLCQVKLDGCVPSLAQFDGKLLVQLQRMKVEAPEFYYASLEKKLNMNLVEILTFTEALDKL 708
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A3M6UDU0 (TIR domain-containing protein OS=Pocillopora damicornis OX=46731 GN=pdam_00008109 PE=4 SV=1)

HSP 1 Score: 180.644 bits (457), Expect = 4.994e-45
Identity = 110/361 (30.47%), Postives = 185/361 (51.25%), Query Frame = 3 
Query:  765 RSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKF------HLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIG-VDGSMIEVMLDIRMNSGDYFNNCLKNEFKM-NFIEVVKFHKALNDLI 1823
            RS GF+ KEL  GL  L+ ND  K I+ +E  I+VL   L +++++         +  L F++  K  +       + L K  +  NA++ +   G LW ++ K  +  K    K        +SY W  ++ ++++ + L++    VW+D E+M  STLE MA  +EN+ VV+I  S  YK S NCR EAEYA +++K IIPL+M+  YK   WLG+L GTK++I+F  +   +  V +L+K +        H + P +   +          + + T+     +V  W+ E+V  WL K G+  + +K +    G  +  + ++R    DYF  CL++  ++ N   V+KF K L+ L+
Sbjct:  305 RSNGFSAKELAEGLSHLAINDNNKKILGSEGAIRVLTSTLETSSDDEEQASAAKALWMLAFDDSNKDIIREGNGTVDILHKLHHSQNAEVQKVAAGALWEIEGKT-ARDKAEKMKEGSGNHVMISYQWDAQEVLVQVKNQLQANGYRVWMDLEQMGGSTLETMAKAVENAAVVLICVSQRYKESPNCRSEAEYAYQLRKDIIPLMMQKNYKADGWLGMLLGTKMWIDFQSKHTIDSGVTKLVKELAGRGKDVDHTDGPPEAVIRT-------TEATTLTKQPSGPDVAGWTNEDVKRWLKKIGLAQVCDKDMAEFTGQTLIELQELRGECPDYFYKCLEHTLQLKNMFHVLKFRKELDKLL 657
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A3M6UDH5 (TIR domain-containing protein OS=Pocillopora damicornis OX=46731 GN=pdam_00008108 PE=4 SV=1)

HSP 1 Score: 179.489 bits (454), Expect = 1.773e-44
Identity = 120/401 (29.93%), Postives = 205/401 (51.12%), Query Frame = 3 
Query:  648 SLVTLSYLIDENEINLFDGHXXXXX-XXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKF------HLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYL-KEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKM-NFIEVVKFHKALNDLI 1823
            +L+ L+YL+DE   +L   ++++++  +    +       +S GF+ KEL+ GL RL+ ND  K I+  E  I+VL   + +++++      ++ +  L F N  K  +       E L    +  NA++ +   G LW ++ K  +  K +  K        +SY    ++ ++++ + L++    VW+D E+M  STLE  A  +EN+ VV+I  S  YK S NCR EAEYA ++ K IIPL+ME  YK   WLG+L GTK+ I F  + N +  V + +K +        H + P K  ++I      K  + + T+     +V  W+ E+V  WL+K G+  +  E  +   G  +  + ++R    DYF  CL+  F++ N   V+KF K L+ L+
Sbjct:  274 ALLCLTYLVDEETNHLISANKDLLRFIIAMLDEACEAEDHKSNGFSAKELVEGLGRLAINDNNKKILGNEGAIRVLTSRIKTSSDDEERASAVEALWMLAFANSNKDIIREGDGTMEILRTLHHSQNAEVQKAAAGALWEIEGKT-ARDKADKTKEGSGNHVMISYQRDAQEIMIQVKNQLQANGCRVWMDLEQMSGSTLETRAKAVENAAVVLICVSQRYKESPNCRSEAEYAYQLGKDIIPLMMEENYKADGWLGMLLGTKLCIGFQSKDNIDSGVTKPVKELAGRGKDVDHTDGPPK--KRI-----RKTTATTPTKQPSSPDVAEWTNEDVKRWLEKIGLTQVCDEDMVEFTGQTLIELQELRGECPDYFYKCLERTFQLKNMFHVLKFRKELDKLL 666
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: R7UGJ9 (TIR domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_180933 PE=4 SV=1)

HSP 1 Score: 169.859 bits (429), Expect = 6.347e-44
Identity = 100/301 (33.22%), Postives = 156/301 (51.83%), Query Frame = 3 
Query:  939 LCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKL---ESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFI----GVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDL 1820
            L F+ ++   +     I E L K + H N K+C+  NG LWIL  K    E  P   +++ A     F+SYSWA +++V++I  +LK     VW D E+M  STLEAMA GIENS VV++ AS  YK S NCR EAEY  ++KKPIIPL+++  Y+P  WLG++ G K+YI F  +   +     L+K ++   N  +   + + L+   K  S      V V  VK+W+   + DW  +  +  L +++       +G  +  +  +   + D+F   +     +   EV+    AL +L
Sbjct:   21 LSFDKEVAQNIREEEGIMELLEKLSKHDNVKLCKLCNGALWILKEKAGVREQEPA--SDEKAKEQHIFISYSWAQQEEVVKIKDLLKERGFQVWFDLEQMCGSTLEAMAAGIENSSVVLVCASEKYKVSPNCRTEAEYTFQLKKPIIPLMLQRHYRPDGWLGMMMGAKLYINFDGKYTFDHASMMLLKELQRLGNEQLIPTKSVPLSQAVK--SEDVADAVSVPLVKSWTEAEILDWRGRHSL--LDDRWTRLLGAFNGKRLHQLYKMSTTAPDFFYKYITESMHLELPEVLDLANALEEL 315
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO45030 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU69])

HSP 1 Score: 176.792 bits (447), Expect = 6.601e-47
Identity = 139/517 (26.89%), Postives = 253/517 (48.94%), Query Frame = 3 
Query:  360 IYLMYIILANFSEHDYEF------AGML-ESSNTINYIID------KYLQFDSSNIKNCKENKN--FKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINL-FDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNA-GEKNRSNSRTRIVLVD--------EVKNWSCENVGDWLDKFGIGYLKEKFIG--VDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFI-EVVKFHKALNDLIV 1826
            +    I+  NFS+   EF      AG++ E ++ ++ + D      KY   ++  +K CK  +     + +  +HN +     +  ++  +  K  L ++N     +    +L+ L+YL DE+  +L     E I   +    K  + N  R  GFT  EL  GL +++ ND  K +I     I +L+D+L +  N+       + +  L F+N+ K  ++      E L +  +  +  + +   G+LW ++ K     K +T    +     +SY W  +  ++++ S L++    VW+D E+M  STL+AMA  +EN++VV++  S  YK S NCR EAEYA +++K I+PL+ME  Y+P  WLG++ G K++I+FSD+       Q L  +  F      KL ++I +   G  N   S+   V  D        ++  WS ++V +W++ FG+    +  I   + G +++ +  +R  S ++F + +K +F    + EV+ F   LN L++
Sbjct:  328 VQTATIVTINFSDRSDEFCIGCGEAGLIGELTDMVSKLRDCTASMVKYQNPETQALK-CKTQRGKILNTAMGTMHNLSRRIPCRQYFKKADTVKVLLPMLNDEVSQFAAK-ALLILAYLTDESNNSLIMASEEPIQFLIHILSKSCSSNSNRYLGFTNSELAEGLSQIAVNDSNKKLIGQHGAIPILVDMLANAKNDEQRRCGAEALWVLAFDNENKEAILTTPNAVELLKELQHSEDDSVKKAAAGVLWEIEGKESHTVKESTADEPLRNHVMISYQWDVQPTMIQVKSKLQAAGYRVWMDLEQMGGSTLQAMANAVENAEVVLMCVSQKYKESPNCRSEAEYAFQLRKDIVPLMMEKSYRPDGWLGMIMGAKLWIDFSDK-------QTLRVDDSFE-----KLQKEIGMRGRGRGNVVESKLVAVQHDVVDVFPKIDISKWSKDDVMNWMNGFGLRLGNDSTIASHLSGKLLQRLAKLRSESPEFFYSSVKQDFGFAHLQEVLLFVDELNKLVL 830
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO41008 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5P1])

HSP 1 Score: 166.392 bits (420), Expect = 4.848e-43
Identity = 113/410 (27.56%), Postives = 209/410 (50.98%), Query Frame = 3 
Query:  633 YYGLISLVTLSYLIDENEINLFDGHXXXXXXXXXXXXXXXXXXXRSE-GFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFH----LNRP-----VKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNF---IEVVKFHKALNDLI 1823
            Y+ + +L+ L+YL+DE   +L    E  +  L++ +     +  R   GF   E+  G+ R+++ND+ K +I   +G+ +L  ++    N+      L  +  L F+ + K  L         L       + ++ +   GILW ++ K+      ++++  ++     SY W N+  +L +   LK     VW+D E+M  STLEAMA  +EN+ V++IA S  Y++S NCR EAEYA + +K I+PL+ME  Y+P  WLG++ G K++++F  R + +  +  L+K ++++    L +P     V     I     +++     T +V   +V  W  E+V  WL   G+    +    +DGSM+ ++  ++  S +++   +K +  M+F   IEV++F + L  L+
Sbjct:  853 YFVMNALLCLAYLVDERNNDLIMADEEPITFLLRMLSSAISDSRRQHLGFAAWEIACGIGRVASNDKNKRLIGRHDGVSILSTLVKEAKNDAERVYGLQALYMLSFDGENKKILCKDKATVNLLRNLKQSGHKEVQKAAVGILWEIEGKVGRDRNEDSQQHIMI-----SYQWDNQKAMLAVNKRLKEAGHKVWMDVEQMGGSTLEAMARAVENASVILIAMSQRYQDSPNCRSEAEYAFQRRKKIVPLMMEQDYRPDGWLGMILGAKLWMDF--RESVDTGIVHLMKELQYNQTAALQQPHDPVTVDTTTVISSPPDKEDGPPGPTDVVDRPDVSKWKKEDVAKWLSDIGLSSSNKVRKKLDGSMLILLYRLKQESPEFYYASVKKD--MDFPTVIEVLQFTEELRKLV 1253

HSP 2 Score: 129.798 bits (325), Expect = 3.580e-31
Identity = 60/132 (45.45%), Postives = 86/132 (65.15%), Query Frame = 3 
Query: 1131 FMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVK 1526
             +SY W  +D VL++   L++    VWID E+M  STLEAMA+ +EN+  V++  S AYK S NCR EAEY+ +++K IIPL+ME +YKP  WLGI+ G K++++F  +   +  VQ LIK +     RP K
Sbjct:  556 MLSYQWGYQDVVLKVRDELRAAGYKVWIDVEQMEGSTLEAMASAVENAAAVLMCVSRAYKESPNCRSEAEYSFQLRKDIIPLMMEPQYKPDGWLGIIVGAKLWMDFRSKDATSSAVQGLIKELG-QRGRPAK 686
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO33720 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRG5])

HSP 1 Score: 93.2041 bits (230), Expect = 2.938e-23
Identity = 43/75 (57.33%), Postives = 55/75 (73.33%), Query Frame = 3 
Query: 1227 MISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFS 1451
            M  STLEAMA  +ENS VV++ AS  YK+S N R EAEYA   KKPI+PL+ME+ YKP  WLG++ G+K+Y  F+
Sbjct:    1 MGGSTLEAMANAVENSAVVLMCASRKYKDSVNYRSEAEYAYTQKKPIVPLMMENGYKPDGWLGMIMGSKLYFNFA 75
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO39316 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAI7])

HSP 1 Score: 73.9442 bits (180), Expect = 2.249e-14
Identity = 47/165 (28.48%), Postives = 78/165 (47.27%), Query Frame = 3 
Query: 1131 FMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLE-AMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKP----IIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVK 1610
             +SY W  +D V ++   L++Y + VW+D    I   +  +MA G++ + ++    ST Y  S NC+ E  YA          I+P++ E  +K   WLGI+    ++I+F D  N    V+ L + I       V  +  I L   EK  + S++ +    EVK
Sbjct:    5 MLSYQWDIQDLVKKVYDGLRAYGIRVWMDIHGGIRGDINGSMAKGVDGAAILCCFMSTKYSESKNCKKELSYADGKTGCEEVIIVPVMCEKGFKAKGWLGIITAGLLWIDFRDEANFENSVKSLAQEIM----HAVGDSSDITLAPDEKQEAASKSVVKPTAEVK 165
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO47001 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN39])

HSP 1 Score: 67.781 bits (164), Expect = 1.046e-11
Identity = 37/134 (27.61%), Postives = 72/134 (53.73%), Query Frame = 3 
Query: 1131 FMSYSWANKDKVLEICSILKSYNVNVWIDREEMI--SSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEH-KYKPSNWLGILFGTKVYIEFS--DRRNANEQVQQLIKNIKFHLNR 1517
            F+SY W  ++  LE+   L+   +  W+D  +M    S   ++  G+  +KV++   ++ Y  S NC+ EA     +KKPIIPL+ E   + P+  LG +F   +YI+ +       +++ Q+L++ I+ + ++
Sbjct: 1370 FLSYQWDMQETALELGRQLREAGIECWMDVGQMGGGDSLYASIDAGVRGAKVMLCCVTSRYCASENCQCEATLGGLLKKPIIPLLFEEIPWPPAGQLGPVFAKLLYIDMTQCSENIPSQKFQELVQRIEKYCSK 1503
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000035587.1 (SMESG000035587.1)

HSP 1 Score: 1134.78 bits (2934), Expect = 0.000e+0
Identity = 585/590 (99.15%), Postives = 590/590 (100.00%), Query Frame = 3 
Query:   57 MEILSDEDKLKILPDETMCKILNLENAIKYLSDVIDFLEKIKIADEYNIYNLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINLFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDLIV 1826
            MEILSDEDKLKILPDETMCKILNLENAIKYLSDVIDFLEKIKIADEYNIYNLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFL+IVNLNCDDYYGLISLVTLSYLIDENEINLFDGHENIVKELIKKIKLINENKLRSEGFT+KELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKF+NHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWID+EEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIR+NSGDYFNNCLKNEFKMNFIEVVKFHKALNDLIV
Sbjct:    1 MEILSDEDKLKILPDETMCKILNLENAIKYLSDVIDFLEKIKIADEYNIYNLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFLNIVNLNCDDYYGLISLVTLSYLIDENEINLFDGHENIVKELIKKIKLINENKLRSEGFTIKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFSNHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDQEEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRINSGDYFNNCLKNEFKMNFIEVVKFHKALNDLIV 590
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000035607.1 (SMESG000035607.1)

HSP 1 Score: 389.423 bits (999), Expect = 2.777e-128
Identity = 233/563 (41.39%), Postives = 347/563 (61.63%), Query Frame = 3 
Query:  216 LRISNAFYDYYNKFIDKVCYEFKKRNLV-NLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINLFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILN-STNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNR----------PVKLAEKI-DL-NAGEKNRSNSRTRIV------------LVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDLIV 1826
            +R+SN+++DYYNKFIDKVC  +  + ++ NL    L+  N      E+TI  +   L NFSEH    A  + SS  + Y+IDKY   + S+ + CK ++ FK  +TIIHNF  +  ++  Y++D+IK++F  ++ L+ DDY+G+IS++ LSY+ID  E+++    +NI+  L++KIK  + +  R EGF ++EL+HGLR ++AND +K  I  E GI++LI+++    ++++VIE TL VI+ LCF+N+IK+KLIN  KI   +  +A   + KI + Y+GILW LD K   L    T+   + FD F+SY WANK+++ EI   LK + +  WID+E+M  S++EAMA GIENS V +I  S++YK S NCR EAEYA +IKKPIIPL+ME KYKP+ WLG L G K+Y EFSDRRN NE+V+ LI  I  +L+            VK  +K  DL N+  + ++    +++             + ++K W+ E+V  WLDK  +   K  F  + GS +  M +I +       + LK  F MN IE+VKF  AL +L V
Sbjct:    1 MRLSNSYFDYYNKFIDKVCEHYISKCIITNLYRLLLKLTN------ESTIDYILTFLVNFSEHSEIMACEIGSSEILKYVIDKYFGMNLSDPEECKSSRIFKLYVTIIHNFFRYPHNRSEYKIDDIKQSFFKMIQLDSDDYFGIISMLILSYVIDGKEVDMLIKGQNILHNLLQKIKFTSTSTKRIEGFNLQELMHGLRFIAANDTMKKRIYDE-GIEILINVIKFHKDDKDVIESTLGVIEHLCFDNEIKLKLINSCKIKNLIKPYAKCKSVKIKEIYDGILWELDKKSVDL---KTKSDNMKFDVFISYCWANKEQIEEILESLKIHKIRAWIDKEQMSGSSIEAMAKGIENSAVFIIGVSSSYKKSCNCRHEAEYAFRIKKPIIPLIMEMKYKPTEWLGFLLGNKIYFEFSDRRNPNEEVKGLIVEINRNLHPIDNEVQSKSNSVKNTQKSHDLPNSNSETKNEDCNKVISKSNFPVPSDSDTLGKIKMWTNEDVLKWLDKIQMSGFKTHFKDLSGSHLLTMQEICLKDPSLIRDDLKKTFNMNIIEIVKFETALKNLSV 553
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000079651.1 (SMESG000079651.1)

HSP 1 Score: 348.206 bits (892), Expect = 6.709e-112
Identity = 210/582 (36.08%), Postives = 347/582 (59.62%), Query Frame = 3 
Query:   93 LPDETMCKILNLENAIKYLSDVIDFL----EKIKIADEYNIYNLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSN-IKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINLFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDL-NAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDL 1820
            LP+ ++C   +    I YL+ VI  L    E + +     I ++++RI N+++D+ N  I+K+C  F +++L++ ++ +L   ++  + K+  +  +Y +L NFS+   EFA  L SS  + +IID+  + +  N I +    ++ ++ + +I N A    ++I Y+  E+K++ ++ + L  +D   + S++TLSY+I+++E+NL     N V  ++  IK     + R   +++ EL+ GL R+SAN+EIK  I    GI ++IDIL++   EN IE TL  I  LCFN +IK KLI+ ++I +++  + NH N +I ++++GI+W +  K E + K  ++     FD F+SY+  NK KV+EI + LK +N+ +WID+E+M  S LEAMA GIENS+  +I  S  Y+ S NCR EAEYA + +K IIP+++  ++KP  WLG + G K+Y E S+RRN  E ++ L+  +K  +    +  +       G     N+     + +++KNWS      WLD   +GYLK++   +DG ++ VMLDIR  S DYFN  LK EF M F+EV+KFH ALN+L
Sbjct:    4 LPERSICLKFSEAEIIDYLTTVITILDNNRENVDV-----INDMLIRICNSYFDWENH-INKICQLFIEKHLLDTVYIYLDYFHRKLNIKDKLVNYLYTLLTNFSDASVEFAQNLNSSKVLPFIIDQCTKKEFINDIHDENIKEHLENCVLVISNVARDLGNQIEYKEKELKESLIEFIKLGNEDKLAIQSMLTLSYIINDSEVNLLVEGSNTVNGILMLIKETCSIEGREGNYSIPELMLGLFRISANNEIKEKIYKNGGIPIIIDILHAKV-ENEIELTLGTIYNLCFNQEIKQKLIDEFEIEKSIKLYENHVNPEIKKYHDGIMWEIRGKNE-IKKKGSDSKKSEFDVFVSYAHQNKSKVMEIFNELKKWNIRIWIDKEQMTGSVLEAMARGIENSRFFIIGISPYYEKSPNCRSEAEYAYQRQKTIIPMILACRFKPEGWLGFIRGMKMYYEISERRNVEEVIEDLVHTLKTGMGDNGEQGKSEHFKEPGPHTDENAVANKSINEKIKNWSTAETASWLDDSKLGYLKKRLNDLDGKLLYVMLDIRSKSPDYFNKTLKKEFGMKFMEVLKFHNALNNL 577
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000079659.1 (SMESG000079659.1)

HSP 1 Score: 338.191 bits (866), Expect = 3.587e-108
Identity = 209/579 (36.10%), Postives = 337/579 (58.20%), Query Frame = 3 
Query:   93 LPDETMCKILNLENAIKYLSDVIDFLEKIKIADEYNIY-NLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKENTIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKENKNF-KSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINLFDGHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDL-NAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDL 1820
            LPDE+ C        I+YL++VI  LE  K   + NI  +L+ RI  A++++ N  +DK+C  F ++NL+  ++ +L++        +  +  +   L NFS+   EFA  +  S  + ++ID+ ++          E K F +  + +I N A    ++I+Y+ +E+K++ ++ + +  +D   + S++ LSY+I ++E+NL     N V  ++  IK       R   +++ EL+ GL R+SAN+EIK  I+   GI ++IDIL++   EN IE TL  I  LCFN +IK KLI+ ++I +++  + NH N  I ++++GI+W +  K E + K  ++     FD F+SY+  NK KV+EI + LK +N+ +WID+E+M  S LEAMA GIENS+  +I  S  Y+ S NCR EAEYA + +K IIP+++  ++KP  WLG + G K+Y E S+RRN  E ++ L+  +K  +    +  +      AG     N+     + +++KNWS      WLD   +GYLK++   +DG ++ VM DIR  S DYFN  LK EF M F+EV+KFH ALN+L
Sbjct:    4 LPDESDCAEFEEPQIIEYLNEVIKILEDNKNEIDINIAGDLLNRIICAYFNWDNH-VDKICQLFIEKNLLETLYLYLKHFLLEFQLDDERLDALLKSLMNFSDASVEFAHKIYCSEILKFLIDQCIEKKVIT----DETKEFVRCCVIVISNVARDLGNQIDYKANELKESLIEFIKIGNEDKLAVQSMLMLSYIIKDSEVNLLVEGSNTVNSILMLIKKTASFNKRKGNYSIPELMLGLFRISANNEIKEKINQNGGIPIIIDILHAKV-ENEIELTLGTIYNLCFNQEIKQKLIDEFEIEKSIKLYENHVNPVIKKYHDGIMWEIRGKNE-IKKKGSDSKKSEFDVFVSYAHQNKSKVMEIFNELKKWNIRIWIDKEQMTGSVLEAMARGIENSRFFIIGISPYYEKSPNCRSEAEYAYQRQKTIIPMILACRFKPEGWLGFIRGMKMYYEISERRNVEEVMEDLVHTLKTGMGDNGEQGKSEHFKEAGPHTDENAVANKSINEKIKNWSTAETASWLDDSKLGYLKKRLNDLDGKLLYVMFDIRSKSPDYFNKTLKKEFGMKFMEVLKFHNALNNL 575
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000015387.1 (SMESG000015387.1)

HSP 1 Score: 310.842 bits (795), Expect = 2.079e-97
Identity = 186/494 (37.65%), Postives = 289/494 (58.50%), Query Frame = 3 
Query:  381 LANFSEHDYEFAGMLESSNTINYIIDKYLQFDS-SNIKNCKENKNFKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLVTLSYLIDENEINLFD-GHXXXXXXXXXXXXXXXXXXXRSEGFTVKELIHGLRRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNNDIKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLES--------LPKGNTEKTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHL-NRPVKLAEKIDLNAGEK---NRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIEVMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDL 1820
            L N+ +   E A  +  ++   Y+I   L      N+KN       K+ I+IIHN      ++  +++ E+K   + ++  N  D+  LIS++TLS L++E+E++L D G  +I   ++K       +  +  GF + EL++GL+ +SAND +K  I TENGI+++ DIL +   +N IE  L V+  LCF+ DIK  L+N + +   + +F NH  + I + YNGILW++D K++S        L K    KT   FD F+SY WANK  VL I   L   N+ +WID ++M  STLEAMA GIENS + ++A S AY+ S NCR EAEYA  + KPIIPL++E KYKP++WLGI+ G+K+Y EFS RRN  E +  L+ N+   + N   K+  +I +   +      S+  T  +L   V +WS + V  WL K G+G++K +F+  DG ++  ++D++  S  Y  + LK E+ M FI+++K H A+N++
Sbjct:  104 LWNYCDGFQEIANEIVVTDLPQYLIANLLHRPYLDNMKNTNIFYLIKASISIIHNIVRCPGNEEKFQIIELKNVLVGLIKRNDSDFIVLISMLTLSCLVNESELHLLDEGKNSIKALIMKIRTAFENDSKKVNGFAIWELVNGLKCVSANDNVKKTIVTENGIKLIFDILKNPTCDNDIEKCLGVLWNLCFDKDIKAILVNDFDLKLFINRFKNHKLSTIKRCYNGILWLIDEKIQSKERILSAHLSKVKASKTHWKFDVFISYCWANKQMVLSIRDFLVQSNIKIWIDLDQMKGSTLEAMADGIENSNIFIMAISEAYRTSPNCRTEAEYAFSLNKPIIPLIVEMKYKPTSWLGIIMGSKMYYEFSKRRNFEESIHSLLANVNTIIQNVERKIVTEIIVPVAQNESYQSSDGGTPKIL--SVHSWSNKIVEKWLVKNGLGHVKSRFMNFDGKLLFSLIDVKNKSRKYLIDALKVEYGMKFIDLLKLHSAINEI 595
The following BLAST results are available for this feature:
BLAST of TIR domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
W4XMC66.457e-5128.67TIR domain-containing protein OS=Strongylocentrotu... [more]
A0A210QF191.195e-4529.76Vacuolar protein 8 OS=Mizuhopecten yessoensis OX=6... [more]
A0A3M6UDU04.994e-4530.47TIR domain-containing protein OS=Pocillopora damic... [more]
A0A3M6UDH51.773e-4429.93TIR domain-containing protein OS=Pocillopora damic... [more]
R7UGJ96.347e-4433.22TIR domain-containing protein OS=Capitella teleta ... [more]
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BLAST of TIR domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO450306.601e-4726.89Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO410084.848e-4327.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO337202.938e-2357.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO393162.249e-1428.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470011.046e-1127.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TIR domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000035587.10.000e+099.15SMESG000035587.1[more]
SMESG000035607.12.777e-12841.39SMESG000035607.1[more]
SMESG000079651.16.709e-11236.08SMESG000079651.1[more]
SMESG000079659.13.587e-10836.10SMESG000079659.1[more]
SMESG000015387.12.079e-9737.65SMESG000015387.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013530 ID=SMED30013530|Name=TIR domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1900bp
ATATAGCGAAAAATATAAATATTACGAAATTATTTATTCACTTCTATTAA
ATTAGCATGGAGATTCTTTCTGATGAAGATAAGCTTAAAATTCTTCCTGA
CGAAACAATGTGTAAGATTCTCAATTTAGAAAATGCAATTAAATACCTAT
CAGATGTAATAGATTTTCTAGAAAAAATTAAAATTGCGGATGAATATAAT
ATATATAATCTGATTTTGCGAATATCTAATGCATTTTATGATTATTATAA
CAAATTTATTGACAAAGTTTGCTATGAATTTAAGAAAAGAAATCTAGTAA
ATTTAATTCATTTTTTTCTTCAAAATCAAAACAAAATATCCTCCCAGAAA
GAAAATACGATATATTTAATGTACATAATATTAGCAAATTTTAGTGAGCA
CGATTACGAGTTTGCTGGAATGCTAGAAAGTTCTAATACTATTAATTATA
TTATCGACAAATATTTACAATTTGATTCTTCTAACATTAAAAATTGCAAA
GAAAATAAAAATTTTAAGTCCCTAATAACAATAATTCATAATTTTGCCAG
CCATAAACTTGATAAAATAAATTACAGAGTTGATGAAATAAAAAAGACAT
TCTTGGATATAGTTAATTTGAATTGTGACGATTATTATGGGTTAATTTCA
TTGGTCACTTTATCATATTTAATTGATGAAAATGAAATTAATTTGTTCGA
TGGTCACGAAAATATAGTAAAAGAATTGATAAAAAAAATAAAATTAATAA
ATGAAAATAAATTGAGATCGGAAGGATTTACTGTAAAGGAATTAATTCAT
GGATTAAGACGATTATCGGCAAATGATGAAATAAAAACAATAATTGACAC
AGAAAATGGAATTCAAGTTTTAATCGACATTTTAAACTCAACTAACAATG
AAAATGTAATCGAACCCACTTTAGATGTTATTAAACAGCTATGTTTCAAT
AATGATATTAAAATAAAATTAATTAATCACTACAAAATAGGAGAAACTTT
AACGAAGTTTGCAAACCATAGCAATGCAAAAATTTGCCAACATTACAATG
GAATTTTATGGATATTAGATAACAAATTGGAATCACTCCCCAAAGGAAAC
ACTGAAAAAACCGCAATTGTATTCGATGCTTTCATGAGTTACAGTTGGGC
GAACAAAGATAAAGTATTGGAAATCTGCAGCATATTGAAATCGTACAATG
TCAACGTCTGGATAGATCGGGAAGAAATGATTAGTTCAACGCTCGAAGCC
ATGGCAACCGGCATCGAAAACTCCAAAGTCGTAGTTATAGCTGCCTCAAC
GGCCTACAAAAACAGTTCCAATTGCAGATTGGAAGCCGAATATGCACAGA
AAATAAAAAAACCGATAATTCCTCTCGTCATGGAACATAAATATAAACCG
TCAAATTGGCTGGGGATTTTATTCGGAACGAAAGTCTATATCGAGTTCAG
TGATCGCCGAAATGCCAATGAGCAAGTGCAACAATTAATAAAAAACATTA
AATTTCATTTGAATCGACCTGTCAAGTTAGCTGAGAAAATCGATCTGAAT
GCCGGTGAGAAAAACAGATCGAACTCACGAACGAGAATCGTTTTGGTGGA
TGAAGTGAAGAATTGGAGCTGTGAAAATGTTGGCGATTGGTTGGACAAAT
TTGGAATTGGATATTTGAAGGAGAAATTTATCGGTGTCGACGGATCAATG
ATCGAGGTGATGCTCGATATCAGAATGAATTCGGGGGATTATTTTAATAA
TTGTTTGAAAAATGAATTTAAAATGAATTTTATCGAGGTCGTCAAGTTCC
ATAAAGCTCTCAATGATTTGATCGTTTTTTGATGTTTTTTCTATTTTTAT
TGATTTTTTGCATTTTTAATTTGGATCTGATAAACAGTTTTTTTATTAAT
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protein sequence of SMED30013530-orf-1

>SMED30013530-orf-1 ID=SMED30013530-orf-1|Name=SMED30013530-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=592bp
MEILSDEDKLKILPDETMCKILNLENAIKYLSDVIDFLEKIKIADEYNIY
NLILRISNAFYDYYNKFIDKVCYEFKKRNLVNLIHFFLQNQNKISSQKEN
TIYLMYIILANFSEHDYEFAGMLESSNTINYIIDKYLQFDSSNIKNCKEN
KNFKSLITIIHNFASHKLDKINYRVDEIKKTFLDIVNLNCDDYYGLISLV
TLSYLIDENEINLFDGHENIVKELIKKIKLINENKLRSEGFTVKELIHGL
RRLSANDEIKTIIDTENGIQVLIDILNSTNNENVIEPTLDVIKQLCFNND
IKIKLINHYKIGETLTKFANHSNAKICQHYNGILWILDNKLESLPKGNTE
KTAIVFDAFMSYSWANKDKVLEICSILKSYNVNVWIDREEMISSTLEAMA
TGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSN
WLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLNRPVKLAEKIDLNAG
EKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGIGYLKEKFIGVDGSMIE
VMLDIRMNSGDYFNNCLKNEFKMNFIEVVKFHKALNDLIVF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR035897Toll_tir_struct_dom_sf
IPR000157TIR_dom
IPR011989ARM-like
IPR013761SAM/pointed_sf
IPR016024ARM-type_fold
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0005488binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 467..487
NoneNo IPR availablePANTHERPTHR46270FAMILY NOT NAMEDcoord: 67..589
IPR000157Toll/interleukin-1 receptor homology (TIR) domainSMARTSM00255till_3coord: 355..488
e-value: 0.0081
score: 9.8
IPR000157Toll/interleukin-1 receptor homology (TIR) domainPFAMPF13676TIR_2coord: 359..478
e-value: 2.8E-20
score: 73.1
IPR035897Toll/interleukin-1 receptor homology (TIR) domain superfamilyGENE3DG3DSA:3.40.50.10140coord: 350..485
e-value: 2.7E-16
score: 61.5
IPR035897Toll/interleukin-1 receptor homology (TIR) domain superfamilySUPERFAMILYSSF52200Toll/Interleukin receptor TIR domaincoord: 353..482
IPR011989Armadillo-like helicalGENE3DG3DSA:1.25.10.10coord: 220..345
e-value: 1.1E-6
score: 30.4
IPR016024Armadillo-type foldSUPERFAMILYSSF48371ARM repeatcoord: 90..337
IPR013761Sterile alpha motif/pointed domain superfamilySUPERFAMILYSSF47769SAM/Pointed domaincoord: 511..550