Peptidase C50 domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30013237 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Human
Match: ESPL1 (extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856]) HSP 1 Score: 137.887 bits (346), Expect = 5.704e-32 Identity = 79/255 (30.98%), Postives = 122/255 (47.84%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSR 3404 +++ D+DL ++P ES+ + +TR+P+ L+ + + + ++P TFYV+NP + L TE+ F + W+G G+ + + + L D+ IY GHGAG R+ + ++ L GC SA V G E G+++ Y+ GCP G LWDVTDR+ID++T LL WL P AP+ +V N+ A +LK L G API +GLP R Sbjct: 1892 VLVLDKDLQKLPWESM---PSLQALPVTRLPSFRFLLSYSIIKEYGASPVLSQG----------VDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVGEVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG-----------PGAPLLYYV--NQARQAPRLKYLIGAAPIAYGLPVSLR 2120
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Celegans
Match: sep-1 (Separin homolog sep-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED39]) HSP 1 Score: 92.8189 bits (229), Expect = 9.872e-19 Identity = 56/195 (28.72%), Postives = 96/195 (49.23%), Query Frame = 3 Query: 2826 LEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRS-EAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSRE 3407 L+I+ +Y+++PD+ L ET++ ++ + + +W+GT G + K E S L+ +D + GHG+G K T L+GC S R + + I+ Y CP I G LW VTD EID+F ++++ + E + T M +E + +LK LTG A +++GLP +++ Sbjct: 953 LQIDVQNAYYILDPDNNLGETQKRMVE-YINKFNWEGTVGSAPKSNEISAALSQRDAFFFIGHGSGSSVMPRSVLKQSTCNAISLLMGCGSVRTIPQALGFDGKTAILDYAMAKCPLIVGCLWTVTDGEIDRFLIRMIDDCFEDSKSLTGIDKLRQLSEAM------HEARSKARLKYLTGAAVVMYGLPVVAKQ 1140
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Celegans
Match: sep-1 (Separin homolog sep-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ED39]) HSP 1 Score: 92.8189 bits (229), Expect = 9.872e-19 Identity = 56/195 (28.72%), Postives = 96/195 (49.23%), Query Frame = 3 Query: 2826 LEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRS-EAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSRE 3407 L+I+ +Y+++PD+ L ET++ ++ + + +W+GT G + K E S L+ +D + GHG+G K T L+GC S R + + I+ Y CP I G LW VTD EID+F ++++ + E + T M +E + +LK LTG A +++GLP +++ Sbjct: 953 LQIDVQNAYYILDPDNNLGETQKRMVE-YINKFNWEGTVGSAPKSNEISAALSQRDAFFFIGHGSGSSVMPRSVLKQSTCNAISLLMGCGSVRTIPQALGFDGKTAILDYAMAKCPLIVGCLWTVTDGEIDRFLIRMIDDCFEDSKSLTGIDKLRQLSEAM------HEARSKARLKYLTGAAVVMYGLPVVAKQ 1140
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Celegans
Match: ZK430.5 (pep chromosome:WBcel235:II:4405864:4416553:1 gene:WBGene00022741.1 transcript:ZK430.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK430.5) HSP 1 Score: 76.6406 bits (187), Expect = 9.552e-14 Identity = 39/125 (31.20%), Postives = 63/125 (50.40%), Query Frame = 3 Query: 2826 LEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRS-EAFGMIMYYLTIGCPSIFGLLWDV 3197 L I FY+++PD+ L T++ +L + + +W+G+ G + K E +D L+ +D Y GHG+G + T FL+GC+S R + + +I Y CPS+ G LWDV Sbjct: 976 LNIGLENAFYILDPDNNLNGTKRRMLK-YINKFNWEGSVGSAPKLTEVTDALSKRDAFFYFGHGSGSSVVTQSLIRQTTCNAISFLMGCESVRTIPQAHGFDGTSVIQDYAMAKCPSLVGCLWDV 1099
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Fly
Match: Sse (gene:FBgn0035627 transcript:FBtr0077125) HSP 1 Score: 58.151 bits (139), Expect = 4.414e-8 Identity = 41/133 (30.83%), Postives = 54/133 (40.60%), Query Frame = 3 Query: 2856 VINPDDTLPETEQTILPVFKRQTS-WQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEA-FGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWL 3248 VINPD L + + + F+ S WQ D +Y GHG+G +Y R + +FL GC S R G A +G YY CPSI G L D +D +V +L WL Sbjct: 418 VINPDADLVNSGRRLRSFFEYWLSQWQHLFETVPNEEVMVKQALQADCFVYAGHGSGLQYVNGRIICRARVRSVVFLFGCDSTRMLGTGLYSALYGAHDYYHGALCPSIVGTLMPALDGNMDTVSVTILSRWL 550
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Zebrafish
Match: espl1 (extra spindle pole bodies like 1, separase [Source:ZFIN;Acc:ZDB-GENE-030131-5188]) HSP 1 Score: 159.844 bits (403), Expect = 6.730e-39 Identity = 99/291 (34.02%), Postives = 153/291 (52.58%), Query Frame = 3 Query: 2538 NLKSLIDQMRSDWFTDSDLKWLMDEG-SNLIG--EPK---IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 +L+ L++ M D DL L+ G + L G EP+ ++I D+ L R+P E+I S+ +TRMP++ +++GH S R D+S V + +NP + +YV+NPD LP+TE F + +WQG G++ + + + KD+ IY GHGAG R+ + + T+ L GC SA +V G+ E G+I+ YLT GCP + G LWDVTDR++D+FT LL +WL + + ++ +A LK + G API +GLP Sbjct: 1917 DLQCLLEGMN---VQDKDLLKLLQRGVAELRGREEPQGHTVLILDKYLQRLPWENIAC---LKSQSVTRMPSLHAVLGH---SHLREVDTSCVL-------SCGVNPKQVYYVLNPDGNLPDTENRFKEWFTGERTWQGVCGRAPDPEKLQEAVTTKDLYIYIGHGAGARFLDAQRVLKVPVRTAALLFGCSSAALSVLGQQEGTGIILSYLTAGCPLVLGNLWDVTDRDLDRFTSALLQSWLSAGSGSS-------------LLQHLAKSRSATHLKHIIGAAPIAYGLP 2178
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Xenopus
Match: ESPL1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:100158636]) HSP 1 Score: 143.28 bits (360), Expect = 9.633e-34 Identity = 78/255 (30.59%), Postives = 125/255 (49.02%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSR 3404 +++ D+ L ++P ESI + +TR+P++ L+ + Q +++ + ++P + FYV+NP LP TE+ FK + W+G + K L KD+ IY GHGAG + +T + + + L GC S V G E G+++ YL GCP + G LWDVTDREID++TV L +WL+ + P + +E+ A +LK + G AP+ +GLP R Sbjct: 1673 VLVLDKHLQKLPWESIPC---LQKQSVTRLPSLRFLLSYGLQRKYQPETTLMKG----------VDPKQAFYVLNPHANLPGTEERFRDWFKNEPGWKGVIRSAPKSEMIQSALTKKDLYIYVGHGAGAHFLDVQTLQRLHCNAVVLLFGCSSVALAVRGDLEGAGIVLKYLMAGCPLVLGNLWDVTDREIDRYTVAFLQSWLKAG-------------SGAPLLKYLSESRQAPKLKYIIGAAPVAYGLPVALR 1901
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Mouse
Match: Espl1 (extra spindle pole bodies 1, separase [Source:MGI Symbol;Acc:MGI:2146156]) HSP 1 Score: 137.117 bits (344), Expect = 7.215e-32 Identity = 79/251 (31.47%), Postives = 120/251 (47.81%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 +++ D+DL ++P ES I ++ +TR+P+ RF + + S + ++P TFYV+NP L TE+ F +T W+G G+ + L +D+ IY GHGAG R+ + ++ L GC SA V G E G+++ Y+ GCP G LWDVTDR+ID++T LL WL P AP + ++ A +LK L G AP+ +GLP Sbjct: 1888 VLVLDKDLQKLPWESTPI---LQAQPVTRLPSF----------RFLLSYTVTKEAGASSVLSQGVDPQNTFYVLNPHSNLSSTEERFRASFSSETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG-----------PGAPF--LYYASQARQAPRLKYLIGAAPVAYGLP 2112
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Mouse
Match: Espl1 (extra spindle pole bodies 1, separase [Source:MGI Symbol;Acc:MGI:2146156]) HSP 1 Score: 137.117 bits (344), Expect = 7.215e-32 Identity = 79/251 (31.47%), Postives = 120/251 (47.81%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 +++ D+DL ++P ES I ++ +TR+P+ RF + + S + ++P TFYV+NP L TE+ F +T W+G G+ + L +D+ IY GHGAG R+ + ++ L GC SA V G E G+++ Y+ GCP G LWDVTDR+ID++T LL WL P AP + ++ A +LK L G AP+ +GLP Sbjct: 1888 VLVLDKDLQKLPWESTPI---LQAQPVTRLPSF----------RFLLSYTVTKEAGASSVLSQGVDPQNTFYVLNPHSNLSSTEERFRASFSSETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG-----------PGAPF--LYYASQARQAPRLKYLIGAAPVAYGLP 2112
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q14674|ESPL1_HUMAN (Separin OS=Homo sapiens OX=9606 GN=ESPL1 PE=1 SV=3) HSP 1 Score: 137.887 bits (346), Expect = 2.739e-31 Identity = 79/255 (30.98%), Postives = 122/255 (47.84%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSR 3404 +++ D+DL ++P ES+ + +TR+P+ L+ + + + ++P TFYV+NP + L TE+ F + W+G G+ + + + L D+ IY GHGAG R+ + ++ L GC SA V G E G+++ Y+ GCP G LWDVTDR+ID++T LL WL P AP+ +V N+ A +LK L G API +GLP R Sbjct: 1892 VLVLDKDLQKLPWESM---PSLQALPVTRLPSFRFLLSYSIIKEYGASPVLSQG----------VDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVGEVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG-----------PGAPLLYYV--NQARQAPRLKYLIGAAPIAYGLPVSLR 2120
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Match: sp|P60330|ESPL1_MOUSE (Separin OS=Mus musculus OX=10090 GN=Espl1 PE=1 SV=1) HSP 1 Score: 137.117 bits (344), Expect = 5.047e-31 Identity = 79/251 (31.47%), Postives = 120/251 (47.81%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 +++ D+DL ++P ES I ++ +TR+P+ RF + + S + ++P TFYV+NP L TE+ F +T W+G G+ + L +D+ IY GHGAG R+ + ++ L GC SA V G E G+++ Y+ GCP G LWDVTDR+ID++T LL WL P AP + ++ A +LK L G AP+ +GLP Sbjct: 1888 VLVLDKDLQKLPWESTPI---LQAQPVTRLPSF----------RFLLSYTVTKEAGASSVLSQGVDPQNTFYVLNPHSNLSSTEERFRASFSSETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAG-----------PGAPF--LYYASQARQAPRLKYLIGAAPVAYGLP 2112
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Match: sp|P33144|BIMB_EMENI (Separin OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=bimB PE=4 SV=2) HSP 1 Score: 110.538 bits (275), Expect = 6.007e-23 Identity = 61/189 (32.28%), Postives = 87/189 (46.03%), Query Frame = 3 Query: 2826 LEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 L I+ Y++NP L T++T W G + E D L K + +Y GHG+G +Y RT K + FL+GC S T G E +G M YL G P++ LWDVTD++ID+F +W N H + A V +++ A LK L G AP+V+G+P Sbjct: 1876 LSIDRRNGTYILNPTGDLKTTQETFEKDLSSLKGWTGMVNRQPTEDEFKDSLQSKSLFLYFGHGSGAQYIRGRTVKRLDRCAVAFLMGCSSGTLTEAGEYEPYGTPMNYLQAGSPALVATLWDVTDKDIDRFAKATFEHWGLIGNGHRGNEGIGEAGVALDAAV--SQSRGACVLKYLNGAAPVVYGVP 2062
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5IBC5|ESP1_ARATH (Separase OS=Arabidopsis thaliana OX=3702 GN=ESP1 PE=2 SV=1) HSP 1 Score: 108.997 bits (271), Expect = 1.615e-22 Identity = 65/209 (31.10%), Postives = 111/209 (53.11%), Query Frame = 3 Query: 2631 EPKIIITDRDLCRIPLESI-LIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEK 3254 EP I++ D ++ +P E+I ++R Q + RMP++ + L + + + I+PL +FY++NP L +T+ T F+ Q +++G AG IE ++ L D+ +Y GHG+G +Y R + + + ++ FL+GC S ++G G+ + YL G P+I LWDVTDR+ID+F LL WL++ Sbjct: 1876 EPIILVLDPEVQMLPWENIPILRKQE----VYRMPSVGCISAVLKKRSLQGEPAKSHVASFPL-----IDPLDSFYLLNPGGDLTDTQVTFESWFRDQ-NFEGKAGSEPSAIELTEALETHDLFLYFGHGSGAQYIPRREIEKLDNCSATFLMGCSSGSLWLKGCYIPQGVPLSYLLGGSPAIVATLWDVTDRDIDRFGKALLEAWLQE 2074
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Match: sp|P18296|CUT1_SCHPO (Separin OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cut1 PE=1 SV=3) HSP 1 Score: 94.3597 bits (233), Expect = 4.854e-18 Identity = 64/256 (25.00%), Postives = 118/256 (46.09%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKR---QTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTW 3398 +++ D+ + + P ES+ N + ++R+P++ L L QS N + +E+ Y++NP L T++ +F+ + W+G + +L+ D +Y GHG G +Y ++ L+GC S G E +G + YL+ GCP++ LWDVTD++ID+F++K+L +W N T + A +E+ + L+ L G AP+++G+P + Sbjct: 1596 VLVLDKSVHQFPWESL---PCLNRQSVSRVPSLSILRDILSQSFVVNGEY------------VEVRKEAGSYILNPSLDLKHTQE----MFEHKLVEGGWKGLIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVNSTSICTAV-------SESRSCCHLRYLNGAAPVIYGIPAY 1825
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Match: A0A4E0R6A8 (Separin OS=Fasciola hepatica OX=6192 GN=D915_007118 PE=4 SV=1) HSP 1 Score: 229.18 bits (583), Expect = 2.952e-57 Identity = 165/545 (30.28%), Postives = 258/545 (47.34%), Query Frame = 3 Query: 1929 LEEHAAQFKHVNVPVLHRAVYQRLALHYLSSNAGKTA-YYLSLSIGMGFRQLYLSECFMK-ARNKKSEHA---------ERWTQTLEAAFSCME--------NESLMHAKLSELLPANWTVLQFNMIDEIPISCIKSSSLN-NVDGG------CLGARNCAVLLVTKYQNLQIDGEGMKLTTETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLMDE---------GSNLIGEPKIIITDRDLCRIPLESILI--RGQANSK--CITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEI--------NPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSREDIQLP 3422 +E + + VP L R V L L++L ++ A YL+ S+G+ LY+S + A K S+ A W+ L+ C+ + A A V+Q ++DEI + S + + G LGARN A L+ T+Y L + L ET+VLHGF TG++ LD F+ +++ES ++I DR +W R+K+D L++++ +M DWFT DLKWL+ + + ++I DR L +P E IL ++NS TR ++ ++GHL ++ S P +NLEI NP +TFYV+NP+ L T+QT P+F+ +W G + E + D+ IY GHG G R+ + + + + ++GC S + EGR E + + +L GCP + GLLWDVTDR++D+FT++ L WL + TDT L + + V + A +LK L G + IV+GLP + LP Sbjct: 939 VEAAYRRLAAIPVPNLLRPVCHWLGLYWLGKDSQTQAGRYLAQSVGIAATSLYVSILSSRIAEMKPSQSAMTPPSPEQLSNWSNALKRTKQCVAPCHPLRNPRSNTSSAITDSTESAGLRVIQLCLVDEIAAGTVSPHSFHLDCPSGHQPLPMGLGARNAAYLVATRYTGLS-STDPHALQAETRVLHGFTNTGLKALDSFDELQVESLDSMQIEDRVRYWRTRYKLDSRLEAMLSEMHRDWFTPDDLKWLLGPLPPTVDPICAKSSVATSVVLILDRRLSYLPWEWILSPEDEESNSARPTFTRSFSLPLVLGHL------SSTSRTGPRIAQVANNLEISRSASPTFNPRETFYVLNPEANLSFTQQTFEPIFQGFPTWHGVIRRLPTTEEVNTGFTDHDLFIYLGHGNGSRFLLQTFNQGMCARAVTLVLGCSSGKPRWEGRHEPYSSLFNHLIAGCPLVAGLLWDVTDRDVDRFTLRFLTRWL---CDESDVTDTALERPSLGSCV--SSATTACKLKHLVGKSVIVYGLPIEPNPNYVLP 1471
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Match: A0A504Z543 (Separin OS=Fasciola gigantica OX=46835 GN=FGIG_05654 PE=4 SV=1) HSP 1 Score: 228.024 bits (580), Expect = 6.541e-57 Identity = 163/545 (29.91%), Postives = 256/545 (46.97%), Query Frame = 3 Query: 1929 LEEHAAQFKHVNVPVLHRAVYQRLALHYLSSNAGKTA-YYLSLSIGMGFRQLYLSECFMK-ARNKKSEHA---------ERWTQTLEAAFSCME--------NESLMHAKLSELLPANWTVLQFNMIDEIPISCIKSSSLN-NVDGG------CLGARNCAVLLVTKYQNLQIDGEGMKLTTETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLMDE---------GSNLIGEPKIIITDRDLCRIPLESILI--RGQANSK--CITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEI--------NPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSREDIQLP 3422 +E + + VP L R V L L++L ++ A YL+ S+G+ LY+S + A K S+ A W+ L C+ A A V+Q ++DEI + S + + G LGARN A L+ T+Y L + L ET+VLHGF TG++ LD F+ +++ES ++I DR +W R+K+D L++++ +M DWFT DLKWL+ + + ++I DR L +P E +L ++NS TR ++ ++GHL ++ S P +NLE+ NP +TFYV+NP+ L T+QT P+F+ +W G + E + D+ IY GHG G R+ + + + + ++GC S + EGR E + + +L GCP + GLLWDVTDR++D+FT++ L WL + TDT L + + V + A +LK L G + IV+GLP + LP Sbjct: 938 VEAAYRRLAAIPVPNLLRPVCHWLGLYWLGKDSQTQAGRYLAQSVGIAATSLYVSILSSRIAEMKPSQSAVTPPPPEQLSNWSNALRRTKQCVAPCHPLRNPRSHTSSAITDSTESAGLRVIQLCLVDEIAAGTVSPHSFHLDCPSGHQPLPMGLGARNAAYLVATRYTGLS-STDPHALQAETRVLHGFTNTGLKALDSFDELQVESLDSMQIEDRVRYWRTRYKLDSRLEAMLSEMHRDWFTPDDLKWLLGPLPPTFDPICAKSPVATSVVLILDRRLSYLPWEWVLSPEDEESNSARPTFTRSFSLPLVLGHL------SSTSRTGPRIPQVANNLEVSRSVSPTFNPRETFYVLNPEANLSFTQQTFEPIFQGFPTWHGVIRRLPTTEEVNTGFTDHDLFIYLGHGNGSRFLLQTFNQGMCARAVTLVLGCSSGKPRWEGRHEPYSSLFNHLIAGCPLVAGLLWDVTDRDVDRFTLRFLTRWL---CDESDATDTALERPSLGSCV--SSATTACKLKHLVGKSVIVYGLPIEPNPNYMLP 1470
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Match: A0A183PEH3 (Peptidase C50 domain-containing protein OS=Schistosoma mattheei OX=31246 PE=4 SV=1) HSP 1 Score: 224.557 bits (571), Expect = 3.020e-56 Identity = 163/530 (30.75%), Postives = 252/530 (47.55%), Query Frame = 3 Query: 1947 QFKHVNVPVLHRAVYQRLALHYLS-SNAGKTAYYLSLSIGMGFRQLYLS--------------ECFMKARNKKSEHAERWTQTLEAAFS-CMENESLMHAKLSELLPA-------NWTVLQFNMIDEIPISCIKSSSLNNVDG--------GCLGARNCAVLLVTKYQNLQIDGEGMKLTT---ETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLM--------DEGSNLIGEPKI-IITDRDLCRIPLESILIRGQANSKCITRMPNIISL---IGHLYQSRFRNTDXXXXXXXXXXXXNL-EINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 Q VP L R + Q L +++L + + +LS +IG+G LYLS + + RNKK W L + C N LM + +P V+Q ++DE+ SC KS+ ++ DG LGAR+ LLV++Y I G LTT ET+V+HGF +G + +D F+ ++ ES + I DR +W R+ +D L++L+ ++R +WFT DL WL +E N P + II DR L +P E IL S C M SL +GHL + P L NP + FY++NP+ LP T+QT P+F +SW G G+ E ++ + D+LI+ GHG G ++ + + + + + ++GC S + GR E + + +L GCP + GLLWDVTDR++D+FT++ L NWL K + P + +F+ +A +LK L G + IV+G+P+ Sbjct: 543 QLSSFPVPNLLRPICQWLGIYWLGKGDQLQAGRFLSQAIGIGPTTLYLSILSSRIIHLKSSDSQDSVSDRNKKCN----WFPILNRVMTICAPNNFLMENVIQ--MPTCDDNSSLTVRVIQLCLVDEL--SC-KSNLIDKSDGIYHHTISPYGLGARSGGYLLVSRY----IGISGQSLTTFEVETRVMHGFTHSGFKYMDSFDEIQTESLDSMAIEDRANYWRIRYNLDERLENLLTEIRREWFTKDDLDWLFSREKYCRNNEPQNDYNSPSVVIIPDRRLVYLPWEWILWDRNPTS-CTPTMTRSFSLPLVVGHLATQYMPCQNIEANISPNAEHMKLCSFNPERAFYILNPESNLPSTQQTFEPIFHNLSSWTGVIGRIPTLEEVNNGFTNHDLLIFLGHGNGSQFLLHTFNQGLNARSVTLILGCSSGKPRSAGRHEPYTSLFNHLIAGCPFVCGLLWDVTDRDVDRFTLQFLTNWLGKDGSDDGRDAK--PHGTLGQSIFN--ATSACKLKHLVGKSVIVYGIPS 1054
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Match: A0A3P8IW72 (Peptidase C50 domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS12759 PE=4 SV=1) HSP 1 Score: 224.172 bits (570), Expect = 3.272e-56 Identity = 163/530 (30.75%), Postives = 252/530 (47.55%), Query Frame = 3 Query: 1947 QFKHVNVPVLHRAVYQRLALHYLS-SNAGKTAYYLSLSIGMGFRQLYLS--------------ECFMKARNKKSEHAERWTQTLEAAFS-CMENESLMHAKLSELLPA-------NWTVLQFNMIDEIPISCIKSSSLNNVDG--------GCLGARNCAVLLVTKYQNLQIDGEGMKLTT---ETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLM--------DEGSNLIGEPKI-IITDRDLCRIPLESILIRGQANSKCITRMPNIISL---IGHLYQSRFRNTDXXXXXXXXXXXXNL-EINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 Q VP L R + Q L +++L + + +LS +IG+G LYLS + + RNKK W L + C N LM + +P V+Q ++DE+ SC KS+ ++ DG LGAR+ LLV++Y I G LTT ET+V+HGF +G + +D F+ ++ ES + I DR +W R+ +D L++L+ ++R +WFT DL WL +E N P + II DR L +P E IL S C M SL +GHL + P L NP + FY++NP+ LP T+QT P+F +SW G G+ E ++ + D+LI+ GHG G ++ + + + + + ++GC S + GR E + + +L GCP + GLLWDVTDR++D+FT++ L NWL K + P + +F+ +A +LK L G + IV+G+P+ Sbjct: 543 QLSSFPVPNLLRPICQWLGIYWLGKGDQLQAGRFLSQAIGIGPTTLYLSILSSRIIHLKSSDSQDSVSDRNKKCN----WFPILNRVMTICAPNNFLMENVIQ--MPTCDDNSSLTVRVIQLCLVDEL--SC-KSNLIDKSDGIYHHTISPYGLGARSGGYLLVSRY----IGISGQSLTTFEVETRVMHGFTHSGFKYMDSFDEIQTESLDSMAIEDRANYWRIRYNLDERLENLLTEIRREWFTKDDLDWLFSREKYCRNNEPQNDYNSPSVVIIPDRRLVYLPWEWILWDRNPTS-CTPTMTRSFSLPLVVGHLATQYMPCQNIEANISPNAEHMKLCSFNPERAFYILNPESNLPSTQQTFEPIFHNLSSWTGVIGRIPTLEEVNNGFTNHDLLIFLGHGNGSQFLLHTFNQGLNARSVTLILGCSSGKPRSAGRHEPYTSLFNHLIAGCPFVCGLLWDVTDRDVDRFTLQFLTNWLGKDGSDDGRDAK--PHGTLGQSIFN--ATSACKLKHLVGKSVIVYGIPS 1054
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Match: A0A095C726 (Separin OS=Schistosoma haematobium OX=6185 GN=MS3_06241 PE=4 SV=1) HSP 1 Score: 224.557 bits (571), Expect = 5.824e-56 Identity = 159/527 (30.17%), Postives = 251/527 (47.63%), Query Frame = 3 Query: 1947 QFKHVNVPVLHRAVYQRLALHYLS-SNAGKTAYYLSLSIGMGFRQLYLS--------------ECFMKARNKKSEHAERWTQTLEAAFS-CMENESLMHAKLSELLPA-------NWTVLQFNMIDEIPISCIKSSSLNNVDG--------GCLGARNCAVLLVTKYQNLQIDGEGMK-LTTETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLMDEGSNLIGEPK--------IIITDRDLCRIPLESILIRGQANSKCITRMPNIISL---IGHLYQSRFRNTDXXXXXXXXXXXXNL-EINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 Q VP L R + Q L +++L + + +LS +IG+G LYLS + + RNKK W L + C N LM + +P V+Q ++DE+ SC KS+ ++ D LGAR+ LLV++Y + I G+ ++ ET+V+HGF +G + +D F+ ++ ES + I DR +W R+ +D L++L+ ++R +WFT DL WL EPK +II DR L +P E IL S C M SL +GHL + P L NP + FY++NP+ LP T+QT P+F +SW G G+ E ++ + D+LI+ GHG G ++ + + + + + ++GC S + GR E + + +L GCP + GLLWDVTDR++D+FT++ L NWL K + P + +F+ +A +LK L G + IV+G+P+ Sbjct: 794 QLSSFPVPNLLRPICQWLGIYWLGKGDQLQAGRFLSQAIGIGPTTLYLSILSSRIIHLKSSDSQDSVSDRNKKCN----WFPILNRVMTICAPNNFLMENVIQ--MPTCDDNSSLTVRVIQLCLVDEL--SC-KSNLIDKSDDIYHHTISPYGLGARSGGYLLVSRY--IGISGQSLRTFEVETRVMHGFTHSGFKYMDSFDEIQTESLDSMAIEDRANYWRIRYNLDERLENLLTEIRREWFTKDDLDWLFSREKYCNNEPKNDYNPPSVVIIPDRRLVYLPWEWILWDRNPTS-CTPTMTRSFSLPLVVGHLATQYMPCQNIEANISPNAEHMKLCSFNPERAFYILNPESNLPSTQQTFEPIFHNLSSWTGVIGRIPTLEEVNNGFTNHDLLIFLGHGNGSQFLLHTFNQGLNARSVTLILGCSSGKPRSAGRHEPYTSLFNHLIAGCPFVCGLLWDVTDRDVDRFTLQFLTNWLGKDGSDDGRDAK--PHGTLGQSIFN--ATSACKLKHLVGKSVIVYGIPS 1304
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Cavefish
Match: espl1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:103046696]) HSP 1 Score: 144.05 bits (362), Expect = 4.316e-34 Identity = 88/273 (32.23%), Postives = 137/273 (50.18%), Query Frame = 3 Query: 2592 LKWLMDEGSNLIG--EPK---IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 LK L S L G EP+ ++I D+ L R+P E+I + ++R+P++ +++GH + + N+D ++P + ++V+NPD LPETE+ F + +WQG G S + + + KD+ IY GHGAG R+ + + L GC SA +V+G E G+I+ YL GCP + G LWDVTDR+ID+FT LL +WL + + + + +A LK + G API +GLP Sbjct: 1906 LKLLQKGVSELKGREEPQGHTVLILDKYLQRLPWENISC---LRPRSVSRLPSLQAVLGHGHLQKM-NSDCVLSRG---------VDPQQVYFVLNPDGNLPETEKRFRDWFTSEKTWQGVCGVSPDPDKLQEAITTKDLYIYVGHGAGARFLDAQRVMKGPVQAAALLFGCSSAALSVQGCLEGTGIILSYLIAGCPLVLGNLWDVTDRDIDRFTSALLQSWLSGGSGSSLLQHL-------------STSRDATHLKHMIGAAPIAYGLPV 2152
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Cavefish
Match: espl1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:103046696]) HSP 1 Score: 144.05 bits (362), Expect = 4.423e-34 Identity = 88/273 (32.23%), Postives = 137/273 (50.18%), Query Frame = 3 Query: 2592 LKWLMDEGSNLIG--EPK---IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 LK L S L G EP+ ++I D+ L R+P E+I + ++R+P++ +++GH + + N+D ++P + ++V+NPD LPETE+ F + +WQG G S + + + KD+ IY GHGAG R+ + + L GC SA +V+G E G+I+ YL GCP + G LWDVTDR+ID+FT LL +WL + + + + +A LK + G API +GLP Sbjct: 1947 LKLLQKGVSELKGREEPQGHTVLILDKYLQRLPWENISC---LRPRSVSRLPSLQAVLGHGHLQKM-NSDCVLSRG---------VDPQQVYFVLNPDGNLPETEKRFRDWFTSEKTWQGVCGVSPDPDKLQEAITTKDLYIYVGHGAGARFLDAQRVMKGPVQAAALLFGCSSAALSVQGCLEGTGIILSYLIAGCPLVLGNLWDVTDRDIDRFTSALLQSWLSGGSGSSLLQHL-------------STSRDATHLKHMIGAAPIAYGLPV 2193
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Cavefish
Match: espl1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:103046696]) HSP 1 Score: 135.576 bits (340), Expect = 1.533e-31 Identity = 90/319 (28.21%), Postives = 148/319 (46.39%), Query Frame = 3 Query: 2490 ISDRKAWWSNRHKMDCNLKSLIDQMRSDWFT-DSDLKWLMDEGSNLI---------GEPKIII-----TDRDLCRIPLESILIRGQANSKCITRMPN--IISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 ++D+ WW R +D + Q+R +W + D ++ S +I P +I + + L R+P E+I + ++R+P+ ++ L+ ++ N+D ++P + ++V+NPD LPETE+ F + +WQG G S + + + KD+ IY GHGAG R+ + + L GC SA +V+G E G+I+ YL GCP + G LWDVTDR+ID+FT LL +WL + + + + +A LK + G API +GLP Sbjct: 1497 VADKVQWWDCRKALDARV-----QVRGEWLSLDQRDHCGVNAASAIIRLNVFSQMAKNPLFLIFFVCVSMQYLQRLPWENI---SCLRPRSVSRLPSLQVLFLLEFIFLYFQMNSDCVLSRG---------VDPQQVYFVLNPDGNLPETEKRFRDWFTSEKTWQGVCGVSPDPDKLQEAITTKDLYIYVGHGAGARFLDAQRVMKGPVQAAALLFGCSSAALSVQGCLEGTGIILSYLIAGCPLVLGNLWDVTDRDIDRFTSALLQSWLSGGSGSSLLQHL-------------STSRDATHLKHMIGAAPIAYGLPV 1785
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003513.1 (pep scaffold:Pmarinus_7.0:GL476336:613530:646893:-1 gene:ENSPMAG00000003160.1 transcript:ENSPMAT00000003513.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 138.272 bits (347), Expect = 4.275e-33 Identity = 82/256 (32.03%), Postives = 124/256 (48.44%), Query Frame = 3 Query: 2640 IIITDRDLCRIPLESI-LIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQ---LKTLTGNAPIVFGLPT 3395 ++I D++L ++P E+I L+R + +TRMP++ L+ +++ ++ N +++ TFY++NP L TE T F+ + W+G GK + +VL KD+ IY GHGAG + F + L GC S + G EA G+ + Y+ GCP I G LWDVTDR+ID++ LL WL AP P ++A Q LK L G API++GLP Sbjct: 1395 VLILDKNLQKLPWENIPLLRASS----VTRMPSLAFLLASALSTKYVKSNVF----------NSKVDVRNTFYLLNPQANLSSTESTFRDWFESEKDWEGVTGKVPTAEKIQEVLTKKDLYIYAGHGAGAQIFKPHAIPRLDCRAVSLLFGCSSGALAMRGTLEASGIALNYIMAGCPCILGNLWDVTDRDIDRYMEALLRTWLS---------------AP-PGASISEHMVHARQAPRLKFLIGAAPILYGLPV 1620
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Yeast
Match: ESP1 (Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003330]) HSP 1 Score: 92.4337 bits (228), Expect = 2.971e-19 Identity = 56/183 (30.60%), Postives = 87/183 (47.54%), Query Frame = 3 Query: 2856 VINPDDTLPETEQTILPVFKR----QTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLP 3392 ++NP+ L TE +F++ + S Q + + +L + ++ +Y GHG G +Y + K T FL+GC SA G+ E G I YL GCP + G LWDVTD++IDKF+ +L EK D L + +++ L+ L G AP+++GLP Sbjct: 1449 ILNPNGDLSRTESKFKGMFQKIIDAKPSSQLVMNEKPEEETLLKMLQNSNLFVYIGHGGGEQYVRSKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEEL----FEKMGFRCNTDD--LNGNSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLP 1625
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Nematostella
Match: EDO43603 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYA6]) HSP 1 Score: 135.576 bits (340), Expect = 5.843e-32 Identity = 76/258 (29.46%), Postives = 125/258 (48.45%), Query Frame = 3 Query: 2634 PKIIITDRDLCRIPLESI-LIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSR 3404 P I+I + + +P E+I ++R +TRMP++ ++ H Q + ++P KT++V+NPDD LP T++ F+ + W+G G + + L D+ +Y GHG G + + + ++ L+GC S + VEG E GM++ YL GCP++ LWDVTDR+ID+ T LL WL Q D L +A + A +L L G +P+V+G+P + + Sbjct: 1860 PVILILGKGVQHLPWENIPILRDHE----VTRMPSLQFVLSHAQQMMHQPCS---------------VDPEKTYFVLNPDDNLPNTQKLFQKWFEGEPGWRGVTGTKPSQEQYRSALVDNDLFLYLGHGNGRTFLNGSEVQRLNCRSTAILMGCSSGKLIVEGVCEPRGMVLNYLIAGCPAVVANLWDVTDRDIDRLTATLLKTWL--------QRDHSLSLAQALC-----QARKACKLGYLIGASPVVYGIPVYRK 2085
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Medaka
Match: espl1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:101174584]) HSP 1 Score: 140.198 bits (352), Expect = 6.233e-33 Identity = 87/258 (33.72%), Postives = 125/258 (48.45%), Query Frame = 3 Query: 2631 EPK---IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 EPK ++I D+ L ++P E + I ++ ++RMP++ SL+G Q ++ DS V +NP K FYV++PD L + F + WQG G + + +A KD+ IY GHGAG R+ + + L GC SA V G E G+++ YL GCP I G LWDVTDR+ID+FT LL +WL + + F + A LK L G AP+V+GLP Sbjct: 1755 EPKGHVVLILDKFLQKLPWEGMSI---LKTQSVSRMPSLHSLLGLNIQ---KDADSQSVLSSG-------VNPRKVFYVLDPDANLKNAQDRFKDWFCSKPDWQGVCGVPPDSGQLEEAVAIKDLYIYVGHGAGARFLDSHSVLKQRMRAASLLFGCSSAALAVRGNQEGQGILLNYLIAGCPFILGNLWDVTDRDIDRFTKALLESWLSAGSGAS-------------ILEFMASSRQATNLKYLIGAAPVVYGLPV 1986
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Medaka
Match: espl1 (extra spindle pole bodies like 1, separase [Source:NCBI gene;Acc:101174584]) HSP 1 Score: 139.813 bits (351), Expect = 7.852e-33 Identity = 87/258 (33.72%), Postives = 125/258 (48.45%), Query Frame = 3 Query: 2631 EPK---IIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPT 3395 EPK ++I D+ L ++P E + I ++ ++RMP++ SL+G Q ++ DS V +NP K FYV++PD L + F + WQG G + + +A KD+ IY GHGAG R+ + + L GC SA V G E G+++ YL GCP I G LWDVTDR+ID+FT LL +WL + + F + A LK L G AP+V+GLP Sbjct: 1931 EPKGHVVLILDKFLQKLPWEGMSI---LKTQSVSRMPSLHSLLGLNIQ---KDADSQSVLSSG-------VNPRKVFYVLDPDANLKNAQDRFKDWFCSKPDWQGVCGVPPDSGQLEEAVAIKDLYIYVGHGAGARFLDSHSVLKQRMRAASLLFGCSSAALAVRGNQEGQGILLNYLIAGCPFILGNLWDVTDRDIDRFTKALLESWLSAGSGAS-------------ILEFMASSRQATNLKYLIGAAPVVYGLPV 2162
BLAST of Peptidase C50 domain-containing protein vs. Planmine SMEST
Match: SMESG000017514.1 (SMESG000017514.1) HSP 1 Score: 2038.46 bits (5280), Expect = 0.000e+0 Identity = 1060/1129 (93.89%), Postives = 1062/1129 (94.07%), Query Frame = 3 Query: 45 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQGLFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISXXXXXXXXXXXXXXXLLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGSYETLRFLWKFINCLLIGLQMIAEYYTLAGIARESKQYQTELFTYSVRYCVPYRTKMAVKLLMHSEFVYMRIPELTIRDSQLTQLKTNQATLNNSIHSNSQRSSLGADVAEYNYPIYHQNEDNLLTASLQNREAAKPHKKDALYITTVTSEKAIHFEECFLSRSTFKTELLDIFDIVKSHIWKIQPTSQSFYDDNEWEMNFIXXXXXXXXXXXXXXINLSTPPSSPIKTTNSXXXXXXXXXXXXXXXXXPIRTRRVGPNPPNKPMIYKKSVKDKQNNSDDAAPIESFQTVYLPGKQRNIKYEDPELPRSLLNHFNKISIKDIPNPIIGTPCNLRFDHFKEYPTLEPKTVVKKARNSKSEQSLIDYLEEHAAQFKHVNVPVLHRAVYQRLALHYLSSNAGKTAYYLSLSIGMGFRQLYLSECFMKARNKKSEHAERWTQTLEAAFSCMENESLMHAKLSELLPANWTVLQFNMIDEIPISCIKSSSLNNVDGGCLGARNCAVLLVTKYQNLQIDGEGMKLTTETKVLHGFRKTGMQLLDRFEYVKLESTRRLKISDRKAWWSNRHKMDCNLKSLIDQMRSDWFTDSDLKWLMDEGSNLIGEPKIIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDXXXXXXXXXXXXNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSREDIQLPKFE 3431 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQGLFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISFAKIIF+KIDPDFKILLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGSYETLRFLWKFINCLLIGLQMIAEYYTLAGIARESKQYQTELFTYSVRYCVPYRTKMAVKLLMHSEFVYMRIPELTIRDSQLTQLKTNQATLNNSIHSNSQRSSLGADVAEYNYPIYHQNEDNLLTASLQNREAAKPHKKDALYITTVTSEKAIHFEECFLSRSTFKTELLDIFDIVKSHIWKIQPTSQSFYDDNEWEMNFIEEDEDNNLSNELVNINLSTPPSSPIKTTNSMNNNNHHHLLNMANMNAPIRTRRVGPNPPNKPMIYKKSVKDKQNNSDDAAPIESFQTVYLPGKQRNIKYEDPELPRSLLNHFNK +PKTVVKKARNSKSEQSLIDYLEEHAAQFKHVNVPVLHRAVYQRLALHYLSSNAGKTAYYLSLSIGMGFRQLYLSECFMKARNKKSEHAERWTQTLEAAFSCMENESLMHAKLSELLPANWTVLQFNMIDEIPISCIKSSSLNNVDGGCLGARNCAVLLVTKYQNLQIDGEGMKLTTETKVLHGFRKT SLIDQMRSDWFTDSDLKWLMDEGSNLIGEPKIIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDSSEVPVPRVSRSNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSREDIQLPKFE Sbjct: 1 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQGLFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISFAKIIFEKIDPDFKILLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGSYETLRFLWKFINCLLIGLQMIAEYYTLAGIARESKQYQTELFTYSVRYCVPYRTKMAVKLLMHSEFVYMRIPELTIRDSQLTQLKTNQATLNNSIHSNSQRSSLGADVAEYNYPIYHQNEDNLLTASLQNREAAKPHKKDALYITTVTSEKAIHFEECFLSRSTFKTELLDIFDIVKSHIWKIQPTSQSFYDDNEWEMNFIEEDEDNNLSNELVNINLSTPPSSPIKTTNSMNNNNHHHLLNMANMNAPIRTRRVGPNPPNKPMIYKKSVKDKQNNSDDAAPIESFQTVYLPGKQRNIKYEDPELPRSLLNHFNK----------------------------KPKTVVKKARNSKSEQSLIDYLEEHAAQFKHVNVPVLHRAVYQRLALHYLSSNAGKTAYYLSLSIGMGFRQLYLSECFMKARNKKSEHAERWTQTLEAAFSCMENESLMHAKLSELLPANWTVLQFNMIDEIPISCIKSSSLNNVDGGCLGARNCAVLLVTKYQNLQIDGEGMKLTTETKVLHGFRKT---------------------------------------SLIDQMRSDWFTDSDLKWLMDEGSNLIGEPKIIITDRDLCRIPLESILIRGQANSKCITRMPNIISLIGHLYQSRFRNTDSSEVPVPRVSRSNLEINPLKTFYVINPDDTLPETEQTILPVFKRQTSWQGTAGKSDKRIEPSDVLAHKDMLIYCGHGAGGRYFMDRTYKSITSPTSMFLIGCQSARFTVEGRSEAFGMIMYYLTIGCPSIFGLLWDVTDREIDKFTVKLLCNWLEKANHHTQQTDTYLPVAPMPAFVFDNETINAVQLKTLTGNAPIVFGLPTWSREDIQLPKFE 1062
BLAST of Peptidase C50 domain-containing protein vs. Planmine SMEST
Match: SMESG000017512.1 (SMESG000017512.1) HSP 1 Score: 498.819 bits (1283), Expect = 1.297e-168 Identity = 262/264 (99.24%), Postives = 263/264 (99.62%), Query Frame = 3 Query: 45 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQGLFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISXXXXXXXXXXXXXXXLLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGS 836 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQ LFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISFAKIIF+KIDPDFKILLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGS Sbjct: 1 MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQRLFTDVSVDKALKFINDEYSSLNITRSIVHQGNVKQQLRTLELMMIIYQLHGKFEEEYKCIKIFNKIARQNKDTEEQSLGFLIESFYHLIHDSKSTIPKICIQIREKLVIINQNISGFTTLNVFISFAKIIFEKIDPDFKILLDKIKQFYVDFQSYFNGNTLESHLVKMYCAQCEFAIKVKAFRSGYRAVNANLFEDGILLRKVSMGSIEYLRKKSSNMNLHSGS 264 The following BLAST results are available for this feature:
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Peptidase C50 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Peptidase C50 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Peptidase C50 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Peptidase C50 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30013237 ID=SMED30013237|Name=Peptidase C50 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3473bpback to top protein sequence of SMED30013237-orf-1 >SMED30013237-orf-1 ID=SMED30013237-orf-1|Name=SMED30013237-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1130bp MPLIVDNIKNYFETLKICSAGNNIHNLNSKEEIKDTEVQGLFTDVSVDKAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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