zf-3CxxC domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30013183 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Human
Match: RTP3 (receptor transporter protein 3 [Source:HGNC Symbol;Acc:HGNC:15572]) HSP 1 Score: 47.7506 bits (112), Expect = 9.193e-6 Identity = 33/113 (29.20%), Postives = 53/113 (46.90%), Query Frame = 2 Query: 335 RFMCSNCSNVWTTMFGAVTFCV---YEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENV----------SRYILNTGMPVKSIKTGNPKGCHREDACQACQAKIC 634 RF CS+CS W + V F + E++ + ++ Q+C KC F+ P + E I R+L+N+ R+ L +P+ IK + +G H D C+AC C Sbjct: 52 RFQCSSCSRNWASAQVLVLFHMNWSEEKSRGQVKMRVFTQRCKKCPQPLFEDPEFTQENISRILKNLVFRILKKCYRGRFQLIEEVPM--IKDISLEGPHNSDNCEACLQGFC 162
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Mouse
Match: Rtp4 (receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025]) HSP 1 Score: 46.9802 bits (110), Expect = 3.333e-6 Identity = 25/73 (34.25%), Postives = 37/73 (50.68%), Query Frame = 2 Query: 335 RFMCSNCSNVWTTMFGAVTFCVYEE---NGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILN 544 RF CS C WT+ + +Y + + ++ GQKC KC F+TP + E I+R+L N+ YIL Sbjct: 54 RFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQ 126
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Mouse
Match: Rtp4 (receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025]) HSP 1 Score: 47.7506 bits (112), Expect = 6.827e-6 Identity = 33/107 (30.84%), Postives = 47/107 (43.93%), Query Frame = 2 Query: 335 RFMCSNCSNVWTTMFGAVTFCVYEE---NGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIK-TGNP--------KGCHREDACQAC 619 RF CS C WT+ + +Y + + ++ GQKC KC F+TP + E I+R+L N+ YIL + I T N G H C+AC Sbjct: 54 RFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEAC 160
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Mouse
Match: Rtp4 (receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025]) HSP 1 Score: 47.7506 bits (112), Expect = 6.827e-6 Identity = 33/107 (30.84%), Postives = 47/107 (43.93%), Query Frame = 2 Query: 335 RFMCSNCSNVWTTMFGAVTFCVYEE---NGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIK-TGNP--------KGCHREDACQAC 619 RF CS C WT+ + +Y + + ++ GQKC KC F+TP + E I+R+L N+ YIL + I T N G H C+AC Sbjct: 54 RFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEAC 160
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Mouse
Match: Rtp4 (receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025]) HSP 1 Score: 47.7506 bits (112), Expect = 6.827e-6 Identity = 33/107 (30.84%), Postives = 47/107 (43.93%), Query Frame = 2 Query: 335 RFMCSNCSNVWTTMFGAVTFCVYEE---NGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIK-TGNP--------KGCHREDACQAC 619 RF CS C WT+ + +Y + + ++ GQKC KC F+TP + E I+R+L N+ YIL + I T N G H C+AC Sbjct: 54 RFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEAC 160
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Match: A0A1I8I6Y7 (zf-3CxxC domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033475g1 PE=4 SV=1) HSP 1 Score: 112.849 bits (281), Expect = 3.343e-25 Identity = 64/189 (33.86%), Postives = 97/189 (51.32%), Query Frame = 2 Query: 182 LFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILT---------LNESAKVRFMCSNCSNVWTTMFGAVTFCVYEEN----GYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYI--LNTGMPVK----SIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKP 691 + L+Q + IVW F + F + S +W L P +P V T + AKVRF+C C WT+M G V F VY+++ GYV FKL GQKC C ++ ++ IWY EE+E+V+EN+ + L GMP + G+PK H CQAC+ ++C+ + + + ++KP Sbjct: 141 MALSQQMEIVWHERFVDFFSRFS---FGSWHLFPVFDPPDVDNTGIPRNQWRYFKDQAKVRFICYKCQKAWTSMGGQVVFWVYKDDAKNEGYV-HFKLYGQKCTDCNSQYYEHAIWYQEEVEKVIENLYHQVGHLYYGMPAHRKRVDRRMGHPKKEHNSATCQACRDRVCRMGQLQKRKSHGQQQQKKP 325
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Match: A0A1I8I4K3 (zf-3CxxC domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 111.694 bits (278), Expect = 1.095e-24 Identity = 62/171 (36.26%), Postives = 90/171 (52.63%), Query Frame = 2 Query: 182 LFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILT---------LNESAKVRFMCSNCSNVWTTMFGAVTFCVYEEN----GYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYI--LNTGMPVK----SIKTGNPKGCHREDACQACQAKICK 637 + L+Q + IVW F + F + S +W L P +P V T + AKVRF+C C WT+M G V F VY+++ GYV FKL GQKC C ++ ++ IWY EE+E+V+EN+ + L GMP + G+PK H CQAC+ ++C+ Sbjct: 142 MALSQQMEIVWHERFVDFFSRFS---FGSWHLFPVFDPPDVDNTGIPRNQWRYFKDQAKVRFICYKCQKAWTSMGGQVVFWVYKDDAKNEGYV-HFKLYGQKCTDCNSQYYEHAIWYQEEVEKVIENLYHQVGHLYYGMPAHRKRVDRRMGHPKKEHNSATCQACRDRVCR 308
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Match: A0A1S3K363 (receptor-transporting protein 1-like isoform X1 OS=Lingula unguis OX=7574 GN=LOC106178173 PE=4 SV=1) HSP 1 Score: 104.375 bits (259), Expect = 9.756e-23 Identity = 64/183 (34.97%), Postives = 91/183 (49.73%), Query Frame = 2 Query: 131 HFYAQIYAKKRYENDSQLFL---AQNLHIVWFGAFFEKFQKVSDSMAKAWSLIP-FSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFC----VYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNT-----GMPVK-SIKTGNPKGCHREDACQACQAKICK 637 H Y QI K D + + A + IVW G F F + W L+P FS P+ +SAKVRF C C + WT+M G V F V +GYVL FKL GQ+CN+C +E F+ +WY EE+ +V+ NV + P++ + G P+ H + CQAC+ +C+ Sbjct: 58 HVYGQITEKSSKAGDPRAHIKPGAVGMEIVWHGEFDRLF---AQYFPHQWFLMPTFSPPSERWRVFKDSAKVRFQCQECGHGWTSMKGRVVFWFHLNVATNSGYVL-FKLYGQQCNRCKSEKFEHAMWYPEEVIKVVGNVYNRVGQVYYGFYRPPLRIDRRPGKPRNQHNAELCQACKDGLCR 236
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Match: A0A0B7AP26 (zf-3CxxC domain-containing protein OS=Arion vulgaris OX=1028688 GN=ORF133593 PE=4 SV=1) HSP 1 Score: 102.064 bits (253), Expect = 2.406e-22 Identity = 60/168 (35.71%), Postives = 87/168 (51.79%), Query Frame = 2 Query: 167 ENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIP-FSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVY----EENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLEN----VSRYILNTGMPVKSI--KTGNPKGCHREDACQACQAKICK 637 E++ LFL+Q + +VW G F F + AW L+P F P+ +SAKVRF C C + WT+M G V F + +GYV+ FKL GQ+C KC +++ +WY EE+ +V+ N V + P I + G P+ H D CQAC+ +CK Sbjct: 31 ESELGLFLSQRMELVWHGEFDRLF---AQYYPHAWYLVPTFYPPSDRWRVFKDSAKVRFSCQECGHGWTSMKGRVIFWFHLNYTTNSGYVM-FKLYGQQCQKCKNGSYEHAMWYPEEVVKVIGNVYNRVGQIFYGFVRPPLRIDRRQGKPRNQHNADLCQACKEGLCK 194
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Match: A0A2L2YD70 (Putative receptor-transporting protein (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1) HSP 1 Score: 99.3673 bits (246), Expect = 1.120e-21 Identity = 55/161 (34.16%), Postives = 85/161 (52.80%), Query Frame = 2 Query: 197 NLHIVW---FGAFFEKFQKVSDSMAKAWSLIPF-SNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTF-CVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNT--GMPVKSI----KTGNPKGCHREDACQACQAKICKYSR 646 N+ ++W F F +F S W L+P S P+ T +SAKVRF C C + WT+M G +TF C + N V++++L GQ+C+ C + ++ +WY EEIE+VL N+ + + G+ I + G PK H + CQAC+ +C R Sbjct: 13 NVALIWQLIFNKLFSRFAPHS------WRLVPVTSKPSGRWHTFVDSAKVRFACEACGHGWTSMKGRITFWCAFSNNTGVVAYRLYGQQCDSCKGDGYEPAMWYPEEIEKVLLNIFSRVAHVFYGLERPPIQLNRRPGKPKNPHNSERCQACKDGVCAERR 167
BLAST of zf-3CxxC domain-containing protein vs. Planmine SMEST
Match: SMESG000033796.1 (SMESG000033796.1) HSP 1 Score: 500.36 bits (1287), Expect = 0.000e+0 Identity = 239/240 (99.58%), Postives = 240/240 (100.00%), Query Frame = 2 Query: 98 KMGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET 817 +MGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET Sbjct: 38 QMGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET 277
BLAST of zf-3CxxC domain-containing protein vs. Planmine SMEST
Match: SMESG000033796.1 (SMESG000033796.1) HSP 1 Score: 499.204 bits (1284), Expect = 0.000e+0 Identity = 239/239 (100.00%), Postives = 239/239 (100.00%), Query Frame = 2 Query: 101 MGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET 817 MGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET Sbjct: 1 MGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSDSMAKAWSLIPFSNPASVILTLNESAKVRFMCSNCSNVWTTMFGAVTFCVYEENGYVLSFKLLGQKCNKCTAENFQTPIWYAEEIERVLENVSRYILNTGMPVKSIKTGNPKGCHREDACQACQAKICKYSRSKFPSESADEIEEKPQTSDYESETEILWSIDNSVFKRSLSMPAKPEPINHPIFFSET 239 The following BLAST results are available for this feature:
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of zf-3CxxC domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of zf-3CxxC domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30013183 ID=SMED30013183|Name=zf-3CxxC domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=930bpback to top protein sequence of SMED30013183-orf-1 >SMED30013183-orf-1 ID=SMED30013183-orf-1|Name=SMED30013183-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=240bp MGICVCAECVHFYAQIYAKKRYENDSQLFLAQNLHIVWFGAFFEKFQKVSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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