Death domain protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30013128 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Death domain protein vs. Ensembl Human
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:HGNC Symbol;Acc:HGNC:28002]) HSP 1 Score: 258.07 bits (658), Expect = 4.739e-78 Identity = 169/529 (31.95%), Postives = 264/529 (49.91%), Query Frame = 3
Query: 156 ELCLHEAARQND-----EMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDK----------YGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLA 1694
E LHEAARQN+ E++ R++ + ++ R ALH AA GH +A R+L+ E + +VD D +GM LL +A+FGHL ++Q LV GA I +K G ++H AA+ V +L ++ LD D G + F A + + L+ D + DK A HLA GH + L+++ + +++ ++ + LH A V+LL+ G+ ++ T + LH D+ +LI AG N + QG +PLH+A N P++V LL+++++D++ ++NR+QTPLH E D ++LL+ G +L+ DK GKT L +A R +++S+VDMIIKA+RF + PSD S K+ ++ ++ + LW++A L+ EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA
Sbjct: 16 ERQLHEAARQNNVGRMQELIGRRVNTRARNHV------GRVALHWAAGAGHEQAVRLLL-EHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRF------------------------YRWEKDHPSDP----------------SGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKALFEGLVAIGRRDLA 494
BLAST of Death domain protein vs. Ensembl Human
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:HGNC Symbol;Acc:HGNC:28002]) HSP 1 Score: 240.35 bits (612), Expect = 2.020e-72 Identity = 144/455 (31.65%), Postives = 230/455 (50.55%), Query Frame = 3
Query: 360 MTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLADKIRRELDS 1721
M LL +A+FGHL ++Q LV GA I +K G ++H AA+ V +L ++ LD D G + F A + + L+ D + DK A HLA GH + L+++ + +++ ++ + LH A V+LL+ G+ ++ T + LH D+ +LI AG N + QG +PLH+A N P++V LL+++++D++ ++NR+QTPLH E D ++LL+ G +L+ DK GKT L +A R +++S+VDMIIKA+RF + PSD S K+ ++ ++ + LW++A L+ EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA+ IR++ ++
Sbjct: 1 MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRF------------------------YRWEKDHPSDP----------------SGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKALFEGLVAIGRRDLAENIRKKANA 412 HSP 2 Score: 102.834 bits (255), Expect = 8.011e-23 Identity = 72/257 (28.02%), Postives = 129/257 (50.19%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGK-VSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLL 1028
T LH AA +GH+ ++ + + V++D DK G T AA G L+ + FLV G + ++K+G +H+AA + +L+ + L++Q+ G++ A + + L+ V+ L + N + H A +G E++ +LI + +D SPLH A + F +V LLI ++++ TPLH+ + ++ DI +L+ AG D+N ++ QG T L +A SN S+V +++
Sbjct: 35 TLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI--GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH---AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 286
BLAST of Death domain protein vs. Ensembl Human
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:HGNC Symbol;Acc:HGNC:28002]) HSP 1 Score: 240.35 bits (612), Expect = 2.020e-72 Identity = 144/455 (31.65%), Postives = 230/455 (50.55%), Query Frame = 3
Query: 360 MTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLADKIRRELDS 1721
M LL +A+FGHL ++Q LV GA I +K G ++H AA+ V +L ++ LD D G + F A + + L+ D + DK A HLA GH + L+++ + +++ ++ + LH A V+LL+ G+ ++ T + LH D+ +LI AG N + QG +PLH+A N P++V LL+++++D++ ++NR+QTPLH E D ++LL+ G +L+ DK GKT L +A R +++S+VDMIIKA+RF + PSD S K+ ++ ++ + LW++A L+ EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA+ IR++ ++
Sbjct: 1 MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRF------------------------YRWEKDHPSDP----------------SGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKALFEGLVAIGRRDLAENIRKKANA 412 HSP 2 Score: 102.834 bits (255), Expect = 8.011e-23 Identity = 72/257 (28.02%), Postives = 129/257 (50.19%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGK-VSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLL 1028
T LH AA +GH+ ++ + + V++D DK G T AA G L+ + FLV G + ++K+G +H+AA + +L+ + L++Q+ G++ A + + L+ V+ L + N + H A +G E++ +LI + +D SPLH A + F +V LLI ++++ TPLH+ + ++ DI +L+ AG D+N ++ QG T L +A SN S+V +++
Sbjct: 35 TLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI--GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH---AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 286
BLAST of Death domain protein vs. Ensembl Human
Match: ANKDD1B (ankyrin repeat and death domain containing 1B [Source:HGNC Symbol;Acc:HGNC:32525]) HSP 1 Score: 215.312 bits (547), Expect = 7.501e-62 Identity = 143/487 (29.36%), Postives = 228/487 (46.82%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEE---FKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIR 1706
RTALH A + H+ A L+ + K VD+ DK+G+T + AA+ G LEV+ LV+ GA +N+ G +H A + N V I+EY+ + L+ D G PFLLA + V + L ++ S+ DK A LH A ++G V++L+ Q ++++ + L I T+ A ++ L+ D++ + +PLH+ ++N ++V LL D+DI+N ++QTPLH ++ + VE LL G +L +DK GKT L +A+R ++ +V M+IKAER Y EE +++ D F Q ++ E + LW +A++ L+ +EW++LA W F + I AIE Q + + S++ HG+R L IW HG + +Q P + LYE LV G KLA+K R
Sbjct: 102 RTALHFAVGRNHLSAVDFLL-KHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKGGNTA------------------------------------LHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAER---------------------------------------YYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTLMTQGDPAKQLYEELVHAGFPKLAEKTR 512
BLAST of Death domain protein vs. Ensembl Human
Match: ANKDD1B (ankyrin repeat and death domain containing 1B [Source:HGNC Symbol;Acc:HGNC:32525]) HSP 1 Score: 173.326 bits (438), Expect = 3.120e-47 Identity = 121/444 (27.25%), Postives = 200/444 (45.05%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEE---FKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSY 1580
RTALH A + H+ A L+ + K VD+ DK+G+T + AA+ G LEV+ LV+ GA +N+ G +H A + N V I+EY+ + L+ D G PFLLA + V + L ++ S+ DK A LH A ++G V++L+ Q ++++ + L I T+ A ++ L+ D++ + +PLH+ ++N ++V LL D+DI+N ++QTPLH ++ + VE LL G +L +DK GKT L +A+R ++ +V M+IKAER Y EE +++ D F Q ++ E + LW +A++ L+ +EW++LA W F + I AIE Q ++ +
Sbjct: 59 RTALHFAVGRNHLSAVDFLL-KHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKGGNTA------------------------------------LHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAER---------------------------------------YYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSEKTRH 426
BLAST of Death domain protein vs. Ensembl Celegans
Match: unc-44 (AO49 ankyrin [Source:UniProtKB/TrEMBL;Acc:Q7JP86]) HSP 1 Score: 143.28 bits (360), Expect = 2.817e-35 Identity = 98/323 (30.34%), Postives = 164/323 (50.77%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ LH+A G +L+ G + +D K +TPL AA GH +VV LV +GA IS + K G +H+AA+G+ V+ + HR +DD + ++P +A V AK L+++ D + H+ACK + LL++ + ++ S +PLH A G I IV L++QGAN T G TPLH+ + + D++ +LI+ GA ++ Q + TPLHIA+ +V LLL A+ + +PLH ++ + + ILL A+ + + K G TPL +A++ + +V ++++
Sbjct: 262 SPLHVATKWGRTNMANLLLSRGAI-IDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL-YHR-APVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY---RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE 578 HSP 2 Score: 138.272 bits (347), Expect = 1.234e-33 Identity = 91/323 (28.17%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A L+ + + + D+ K G TPL AA++GH V Q L+EKGA ++ + + +H+A + N+ + R +D + + ++P A L+ + +S K H+A + H + L+ P +D + +PLH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL+K A I G TPLH+A ++V LL A+ D+ R +TPLH N+ D V +L+ GA + + +TPL +A+R +V ++++A
Sbjct: 197 ALHIAAKKDDTTAA-TLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLS--RGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAP---VDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQA 513 HSP 3 Score: 133.65 bits (335), Expect = 3.114e-32 Identity = 88/316 (27.85%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+AA GH ++L+ +G +V+ ++ ++PL A +G + L+ +GA+I R K +H AA +++ + + + + NG++P +A + V +A+ L+ V + H+A GH + LL++ D + + +PLH AC+ IK+VELL++ A + T +G TPLH+ +I++ L++ GA+ + + ++G TPLH+A +N +V +L+ N A +D QTPLH D V +LL GAN + + +PL +AA+
Sbjct: 229 TPLHIAAHYGHENVGQLLLEKG-ANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQG--APISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSA--------DPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAK 533 HSP 4 Score: 127.487 bits (319), Expect = 3.796e-30 Identity = 103/366 (28.14%), Postives = 170/366 (46.45%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKS-----PLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
E + E LH AAR N ++R +I+ A L +T LH+A+ G+ + IL+ + + + + +PL AA G EV L++ A + K+G +H+A++ + ++ + R +D + N ++P +A N A L+E K H+A K I + L++ K D + KS PLH + + G +I LLIE G+++ NG T +H+ Q+ + +L GA+IN + G TPLH+A +MV L++N AD+ TPLH +Q + V LL GA+ + TG+TPL +A R Y+S+V+ +
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQAREL-QTPLHIASRLGNTDIV-ILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE--RGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--------KADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETL 807 HSP 5 Score: 121.709 bits (304), Expect = 2.672e-28 Identity = 90/354 (25.42%), Postives = 164/354 (46.33%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK---------------HRHFKLDDQD----------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +L+ + + +++ + G+TPL AA+ G + +V +L+++GA +G +H+AA N +++ + R H +L + D + SP +A + A L++ + D + L K HLA K G+ + LL+E P ++ K + +PLH A K+ LL+E GA+ NG+TPLHI +K+ +I L++ AD N ++ G TPLH++ + LL++N +D+ N T +H +++ +IL GA +++ G TPL +A ++MV +++
Sbjct: 394 TPLHIACKKNRIKVVELLL-KYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGK---NQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743 HSP 6 Score: 117.472 bits (293), Expect = 5.750e-27 Identity = 110/414 (26.57%), Postives = 173/414 (41.79%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKD----IDVSQL----------------------DKTNKNAW---HLACKNGHENIFNLLIEMEV-----------PKELMDK----------------LDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFAD---------------------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+LH+A+ +GH E R LI + + VD + G T L A+ G +V LVE GA ++ ++ G +++AA+ N +++Y+ + + L +D G +P +A+ + L+E D + + L D T+K+ + H+A GHEN+ LL+E P + K +DS K +PLH A +G ++V+LL+ QGA +S T NG PLH+ Q D + LL+ AD N + + G TPLHIA N +V LLL A ++ TPLH + V LL +GAN G+TPL +AAR + +V ++I+
Sbjct: 69 SLHLASKEGHSEVVRELI-KRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTED--GFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479 HSP 7 Score: 106.686 bits (265), Expect = 1.279e-23 Identity = 84/320 (26.25%), Postives = 144/320 (45.00%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
AA G +E L+ G ++ + G+ L A+ GH EVV+ L+++ A + ++G +HIA+ I+ + + + Q NG +P +A +N K L++ + + + +A + GH+ + +L+E DS K LH A + LL++ N + +GFTPLHI ++ LL++ GA++N Q +PLH+AT +M LLL A +D TPLH V++L+++GA +S K G PL MAA+G ++ ++
Sbjct: 40 AARAGDLEKVLELLRAG-TDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNV--QSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLEN----------DSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL 346 HSP 8 Score: 84.3445 bits (207), Expect = 1.545e-16 Identity = 64/251 (25.50%), Postives = 110/251 (43.82%), Query Frame = 3
Query: 561 GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTP-----------------------------LHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
G + FL A + L+ D++ + N+ HLA K GH + LI+ + +D + LH A G IV +L+E GAN++ + NGFTPL++ Q++ +++ L+K GA+ G TP LHIA + + TLLL N + D+ + TPLH + ++LL +GAN++ + +PL +A + +M ++++
Sbjct: 33 GSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQA---QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLL 280 HSP 9 Score: 75.0998 bits (183), Expect = 9.767e-14 Identity = 42/140 (30.00%), Postives = 84/140 (60.00%), Query Frame = 3
Query: 810 KIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
K++ELL G +++ NG LH+ +++ ++++ LIK A ++ +GNT LHIA+L+ +VT+L++N A++++ + TPL+ ++N + V+ LL GAN + + G TPL +A + + +V ++++
Sbjct: 48 KVLELL-RAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLE 186
BLAST of Death domain protein vs. Ensembl Celegans
Match: unc-44 (AO49 ankyrin [Source:UniProtKB/TrEMBL;Acc:Q7JP86]) HSP 1 Score: 143.28 bits (360), Expect = 2.817e-35 Identity = 98/323 (30.34%), Postives = 164/323 (50.77%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ LH+A G +L+ G + +D K +TPL AA GH +VV LV +GA IS + K G +H+AA+G+ V+ + HR +DD + ++P +A V AK L+++ D + H+ACK + LL++ + ++ S +PLH A G I IV L++QGAN T G TPLH+ + + D++ +LI+ GA ++ Q + TPLHIA+ +V LLL A+ + +PLH ++ + + ILL A+ + + K G TPL +A++ + +V ++++
Sbjct: 262 SPLHVATKWGRTNMANLLLSRGAI-IDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL-YHR-APVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY---RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE 578 HSP 2 Score: 138.272 bits (347), Expect = 1.234e-33 Identity = 91/323 (28.17%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A L+ + + + D+ K G TPL AA++GH V Q L+EKGA ++ + + +H+A + N+ + R +D + + ++P A L+ + +S K H+A + H + L+ P +D + +PLH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL+K A I G TPLH+A ++V LL A+ D+ R +TPLH N+ D V +L+ GA + + +TPL +A+R +V ++++A
Sbjct: 197 ALHIAAKKDDTTAA-TLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLS--RGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAP---VDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQA 513 HSP 3 Score: 133.65 bits (335), Expect = 3.114e-32 Identity = 88/316 (27.85%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+AA GH ++L+ +G +V+ ++ ++PL A +G + L+ +GA+I R K +H AA +++ + + + + NG++P +A + V +A+ L+ V + H+A GH + LL++ D + + +PLH AC+ IK+VELL++ A + T +G TPLH+ +I++ L++ GA+ + + ++G TPLH+A +N +V +L+ N A +D QTPLH D V +LL GAN + + +PL +AA+
Sbjct: 229 TPLHIAAHYGHENVGQLLLEKG-ANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQG--APISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSA--------DPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAK 533 HSP 4 Score: 127.487 bits (319), Expect = 3.796e-30 Identity = 103/366 (28.14%), Postives = 170/366 (46.45%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKS-----PLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
E + E LH AAR N ++R +I+ A L +T LH+A+ G+ + IL+ + + + + +PL AA G EV L++ A + K+G +H+A++ + ++ + R +D + N ++P +A N A L+E K H+A K I + L++ K D + KS PLH + + G +I LLIE G+++ NG T +H+ Q+ + +L GA+IN + G TPLH+A +MV L++N AD+ TPLH +Q + V LL GA+ + TG+TPL +A R Y+S+V+ +
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQAREL-QTPLHIASRLGNTDIV-ILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE--RGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--------KADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETL 807 HSP 5 Score: 121.709 bits (304), Expect = 2.672e-28 Identity = 90/354 (25.42%), Postives = 164/354 (46.33%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK---------------HRHFKLDDQD----------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +L+ + + +++ + G+TPL AA+ G + +V +L+++GA +G +H+AA N +++ + R H +L + D + SP +A + A L++ + D + L K HLA K G+ + LL+E P ++ K + +PLH A K+ LL+E GA+ NG+TPLHI +K+ +I L++ AD N ++ G TPLH++ + LL++N +D+ N T +H +++ +IL GA +++ G TPL +A ++MV +++
Sbjct: 394 TPLHIACKKNRIKVVELLL-KYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGK---NQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743 HSP 6 Score: 117.472 bits (293), Expect = 5.750e-27 Identity = 110/414 (26.57%), Postives = 173/414 (41.79%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKD----IDVSQL----------------------DKTNKNAW---HLACKNGHENIFNLLIEMEV-----------PKELMDK----------------LDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFAD---------------------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+LH+A+ +GH E R LI + + VD + G T L A+ G +V LVE GA ++ ++ G +++AA+ N +++Y+ + + L +D G +P +A+ + L+E D + + L D T+K+ + H+A GHEN+ LL+E P + K +DS K +PLH A +G ++V+LL+ QGA +S T NG PLH+ Q D + LL+ AD N + + G TPLHIA N +V LLL A ++ TPLH + V LL +GAN G+TPL +AAR + +V ++I+
Sbjct: 69 SLHLASKEGHSEVVRELI-KRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTED--GFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479 HSP 7 Score: 106.686 bits (265), Expect = 1.279e-23 Identity = 84/320 (26.25%), Postives = 144/320 (45.00%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
AA G +E L+ G ++ + G+ L A+ GH EVV+ L+++ A + ++G +HIA+ I+ + + + Q NG +P +A +N K L++ + + + +A + GH+ + +L+E DS K LH A + LL++ N + +GFTPLHI ++ LL++ GA++N Q +PLH+AT +M LLL A +D TPLH V++L+++GA +S K G PL MAA+G ++ ++
Sbjct: 40 AARAGDLEKVLELLRAG-TDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNV--QSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLEN----------DSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL 346 HSP 8 Score: 84.3445 bits (207), Expect = 1.545e-16 Identity = 64/251 (25.50%), Postives = 110/251 (43.82%), Query Frame = 3
Query: 561 GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTP-----------------------------LHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
G + FL A + L+ D++ + N+ HLA K GH + LI+ + +D + LH A G IV +L+E GAN++ + NGFTPL++ Q++ +++ L+K GA+ G TP LHIA + + TLLL N + D+ + TPLH + ++LL +GAN++ + +PL +A + +M ++++
Sbjct: 33 GSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQA---QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLL 280 HSP 9 Score: 75.0998 bits (183), Expect = 9.767e-14 Identity = 42/140 (30.00%), Postives = 84/140 (60.00%), Query Frame = 3
Query: 810 KIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
K++ELL G +++ NG LH+ +++ ++++ LIK A ++ +GNT LHIA+L+ +VT+L++N A++++ + TPL+ ++N + V+ LL GAN + + G TPL +A + + +V ++++
Sbjct: 48 KVLELL-RAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLE 186
BLAST of Death domain protein vs. Ensembl Celegans
Match: unc-44 (AO49 ankyrin [Source:UniProtKB/TrEMBL;Acc:Q7JP86]) HSP 1 Score: 142.895 bits (359), Expect = 3.390e-35 Identity = 98/323 (30.34%), Postives = 164/323 (50.77%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ LH+A G +L+ G + +D K +TPL AA GH +VV LV +GA IS + K G +H+AA+G+ V+ + HR +DD + ++P +A V AK L+++ D + H+ACK + LL++ + ++ S +PLH A G I IV L++QGAN T G TPLH+ + + D++ +LI+ GA ++ Q + TPLHIA+ +V LLL A+ + +PLH ++ + + ILL A+ + + K G TPL +A++ + +V ++++
Sbjct: 262 SPLHVATKWGRTNMANLLLSRGAI-IDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL-YHR-APVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY---RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE 578 HSP 2 Score: 137.887 bits (346), Expect = 1.653e-33 Identity = 91/323 (28.17%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A L+ + + + D+ K G TPL AA++GH V Q L+EKGA ++ + + +H+A + N+ + R +D + + ++P A L+ + +S K H+A + H + L+ P +D + +PLH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL+K A I G TPLH+A ++V LL A+ D+ R +TPLH N+ D V +L+ GA + + +TPL +A+R +V ++++A
Sbjct: 197 ALHIAAKKDDTTAA-TLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLS--RGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAP---VDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQA 513 HSP 3 Score: 133.65 bits (335), Expect = 4.130e-32 Identity = 88/316 (27.85%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+AA GH ++L+ +G +V+ ++ ++PL A +G + L+ +GA+I R K +H AA +++ + + + + NG++P +A + V +A+ L+ V + H+A GH + LL++ D + + +PLH AC+ IK+VELL++ A + T +G TPLH+ +I++ L++ GA+ + + ++G TPLH+A +N +V +L+ N A +D QTPLH D V +LL GAN + + +PL +AA+
Sbjct: 229 TPLHIAAHYGHENVGQLLLEKG-ANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQG--APISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSA--------DPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAK 533 HSP 4 Score: 127.102 bits (318), Expect = 4.206e-30 Identity = 103/366 (28.14%), Postives = 170/366 (46.45%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKS-----PLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
E + E LH AAR N ++R +I+ A L +T LH+A+ G+ + IL+ + + + + +PL AA G EV L++ A + K+G +H+A++ + ++ + R +D + N ++P +A N A L+E K H+A K I + L++ K D + KS PLH + + G +I LLIE G+++ NG T +H+ Q+ + +L GA+IN + G TPLH+A +MV L++N AD+ TPLH +Q + V LL GA+ + TG+TPL +A R Y+S+V+ +
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQAREL-QTPLHIASRLGNTDIV-ILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE--RGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--------KADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETL 807 HSP 5 Score: 121.324 bits (303), Expect = 2.933e-28 Identity = 90/354 (25.42%), Postives = 164/354 (46.33%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK---------------HRHFKLDDQD----------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +L+ + + +++ + G+TPL AA+ G + +V +L+++GA +G +H+AA N +++ + R H +L + D + SP +A + A L++ + D + L K HLA K G+ + LL+E P ++ K + +PLH A K+ LL+E GA+ NG+TPLHI +K+ +I L++ AD N ++ G TPLH++ + LL++N +D+ N T +H +++ +IL GA +++ G TPL +A ++MV +++
Sbjct: 394 TPLHIACKKNRIKVVELLL-KYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGK---NQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743 HSP 6 Score: 117.087 bits (292), Expect = 6.421e-27 Identity = 110/414 (26.57%), Postives = 173/414 (41.79%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKD----IDVSQL----------------------DKTNKNAW---HLACKNGHENIFNLLIEMEV-----------PKELMDK----------------LDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFAD---------------------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+LH+A+ +GH E R LI + + VD + G T L A+ G +V LVE GA ++ ++ G +++AA+ N +++Y+ + + L +D G +P +A+ + L+E D + + L D T+K+ + H+A GHEN+ LL+E P + K +DS K +PLH A +G ++V+LL+ QGA +S T NG PLH+ Q D + LL+ AD N + + G TPLHIA N +V LLL A ++ TPLH + V LL +GAN G+TPL +AAR + +V ++I+
Sbjct: 69 SLHLASKEGHSEVVRELI-KRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTED--GFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479 HSP 7 Score: 106.686 bits (265), Expect = 1.504e-23 Identity = 84/320 (26.25%), Postives = 144/320 (45.00%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
AA G +E L+ G ++ + G+ L A+ GH EVV+ L+++ A + ++G +HIA+ I+ + + + Q NG +P +A +N K L++ + + + +A + GH+ + +L+E DS K LH A + LL++ N + +GFTPLHI ++ LL++ GA++N Q +PLH+AT +M LLL A +D TPLH V++L+++GA +S K G PL MAA+G ++ ++
Sbjct: 40 AARAGDLEKVLELLRAG-TDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNV--QSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLEN----------DSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL 346 HSP 8 Score: 83.9593 bits (206), Expect = 1.857e-16 Identity = 64/251 (25.50%), Postives = 110/251 (43.82%), Query Frame = 3
Query: 561 GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTP-----------------------------LHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
G + FL A + L+ D++ + N+ HLA K GH + LI+ + +D + LH A G IV +L+E GAN++ + NGFTPL++ Q++ +++ L+K GA+ G TP LHIA + + TLLL N + D+ + TPLH + ++LL +GAN++ + +PL +A + +M ++++
Sbjct: 33 GSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQA---QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLL 280 HSP 9 Score: 75.0998 bits (183), Expect = 1.095e-13 Identity = 47/169 (27.81%), Postives = 91/169 (53.85%), Query Frame = 3
Query: 723 EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
E++ P S L A K++ELL G +++ NG LH+ +++ ++++ LIK A ++ +GNT LHIA+L+ +VT+L++N A++++ + TPL+ ++N + V+ LL GAN + + G TPL +A + + +V ++++
Sbjct: 19 EVQAPAAPEPGRAEGSASFLRAARAGDLEKVLELL-RAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLE 186
BLAST of Death domain protein vs. Ensembl Celegans
Match: unc-44 (AO49 ankyrin [Source:UniProtKB/TrEMBL;Acc:Q7JP86]) HSP 1 Score: 142.895 bits (359), Expect = 3.390e-35 Identity = 98/323 (30.34%), Postives = 164/323 (50.77%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ LH+A G +L+ G + +D K +TPL AA GH +VV LV +GA IS + K G +H+AA+G+ V+ + HR +DD + ++P +A V AK L+++ D + H+ACK + LL++ + ++ S +PLH A G I IV L++QGAN T G TPLH+ + + D++ +LI+ GA ++ Q + TPLHIA+ +V LLL A+ + +PLH ++ + + ILL A+ + + K G TPL +A++ + +V ++++
Sbjct: 262 SPLHVATKWGRTNMANLLLSRGAI-IDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL-YHR-APVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY---RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE 578 HSP 2 Score: 137.887 bits (346), Expect = 1.653e-33 Identity = 91/323 (28.17%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A L+ + + + D+ K G TPL AA++GH V Q L+EKGA ++ + + +H+A + N+ + R +D + + ++P A L+ + +S K H+A + H + L+ P +D + +PLH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL+K A I G TPLH+A ++V LL A+ D+ R +TPLH N+ D V +L+ GA + + +TPL +A+R +V ++++A
Sbjct: 197 ALHIAAKKDDTTAA-TLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLS--RGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAP---VDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQA 513 HSP 3 Score: 133.65 bits (335), Expect = 4.130e-32 Identity = 88/316 (27.85%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+AA GH ++L+ +G +V+ ++ ++PL A +G + L+ +GA+I R K +H AA +++ + + + + NG++P +A + V +A+ L+ V + H+A GH + LL++ D + + +PLH AC+ IK+VELL++ A + T +G TPLH+ +I++ L++ GA+ + + ++G TPLH+A +N +V +L+ N A +D QTPLH D V +LL GAN + + +PL +AA+
Sbjct: 229 TPLHIAAHYGHENVGQLLLEKG-ANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQG--APISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSA--------DPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAK 533 HSP 4 Score: 127.102 bits (318), Expect = 4.206e-30 Identity = 103/366 (28.14%), Postives = 170/366 (46.45%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKS-----PLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
E + E LH AAR N ++R +I+ A L +T LH+A+ G+ + IL+ + + + + +PL AA G EV L++ A + K+G +H+A++ + ++ + R +D + N ++P +A N A L+E K H+A K I + L++ K D + KS PLH + + G +I LLIE G+++ NG T +H+ Q+ + +L GA+IN + G TPLH+A +MV L++N AD+ TPLH +Q + V LL GA+ + TG+TPL +A R Y+S+V+ +
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQAREL-QTPLHIASRLGNTDIV-ILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE--RGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--------KADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETL 807 HSP 5 Score: 121.324 bits (303), Expect = 2.933e-28 Identity = 90/354 (25.42%), Postives = 164/354 (46.33%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK---------------HRHFKLDDQD----------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +L+ + + +++ + G+TPL AA+ G + +V +L+++GA +G +H+AA N +++ + R H +L + D + SP +A + A L++ + D + L K HLA K G+ + LL+E P ++ K + +PLH A K+ LL+E GA+ NG+TPLHI +K+ +I L++ AD N ++ G TPLH++ + LL++N +D+ N T +H +++ +IL GA +++ G TPL +A ++MV +++
Sbjct: 394 TPLHIACKKNRIKVVELLL-KYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGK---NQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743 HSP 6 Score: 117.087 bits (292), Expect = 6.421e-27 Identity = 110/414 (26.57%), Postives = 173/414 (41.79%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKD----IDVSQL----------------------DKTNKNAW---HLACKNGHENIFNLLIEMEV-----------PKELMDK----------------LDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFAD---------------------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+LH+A+ +GH E R LI + + VD + G T L A+ G +V LVE GA ++ ++ G +++AA+ N +++Y+ + + L +D G +P +A+ + L+E D + + L D T+K+ + H+A GHEN+ LL+E P + K +DS K +PLH A +G ++V+LL+ QGA +S T NG PLH+ Q D + LL+ AD N + + G TPLHIA N +V LLL A ++ TPLH + V LL +GAN G+TPL +AAR + +V ++I+
Sbjct: 69 SLHLASKEGHSEVVRELI-KRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTED--GFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479 HSP 7 Score: 106.686 bits (265), Expect = 1.504e-23 Identity = 84/320 (26.25%), Postives = 144/320 (45.00%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
AA G +E L+ G ++ + G+ L A+ GH EVV+ L+++ A + ++G +HIA+ I+ + + + Q NG +P +A +N K L++ + + + +A + GH+ + +L+E DS K LH A + LL++ N + +GFTPLHI ++ LL++ GA++N Q +PLH+AT +M LLL A +D TPLH V++L+++GA +S K G PL MAA+G ++ ++
Sbjct: 40 AARAGDLEKVLELLRAG-TDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNV--QSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLEN----------DSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL 346 HSP 8 Score: 83.9593 bits (206), Expect = 1.857e-16 Identity = 64/251 (25.50%), Postives = 110/251 (43.82%), Query Frame = 3
Query: 561 GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTP-----------------------------LHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
G + FL A + L+ D++ + N+ HLA K GH + LI+ + +D + LH A G IV +L+E GAN++ + NGFTPL++ Q++ +++ L+K GA+ G TP LHIA + + TLLL N + D+ + TPLH + ++LL +GAN++ + +PL +A + +M ++++
Sbjct: 33 GSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQA---QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLL 280 HSP 9 Score: 75.0998 bits (183), Expect = 1.095e-13 Identity = 47/169 (27.81%), Postives = 91/169 (53.85%), Query Frame = 3
Query: 723 EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
E++ P S L A K++ELL G +++ NG LH+ +++ ++++ LIK A ++ +GNT LHIA+L+ +VT+L++N A++++ + TPL+ ++N + V+ LL GAN + + G TPL +A + + +V ++++
Sbjct: 19 EVQAPAAPEPGRAEGSASFLRAARAGDLEKVLELL-RAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLE 186
BLAST of Death domain protein vs. Ensembl Celegans
Match: unc-44 (AO49 ankyrin [Source:UniProtKB/TrEMBL;Acc:Q7JP86]) HSP 1 Score: 142.895 bits (359), Expect = 4.116e-35 Identity = 98/323 (30.34%), Postives = 164/323 (50.77%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ LH+A G +L+ G + +D K +TPL AA GH +VV LV +GA IS + K G +H+AA+G+ V+ + HR +DD + ++P +A V AK L+++ D + H+ACK + LL++ + ++ S +PLH A G I IV L++QGAN T G TPLH+ + + D++ +LI+ GA ++ Q + TPLHIA+ +V LLL A+ + +PLH ++ + + ILL A+ + + K G TPL +A++ + +V ++++
Sbjct: 262 SPLHVATKWGRTNMANLLLSRGAI-IDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL-YHR-APVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY---RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE 578 HSP 2 Score: 137.502 bits (345), Expect = 1.850e-33 Identity = 91/323 (28.17%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A L+ + + + D+ K G TPL AA++GH V Q L+EKGA ++ + + +H+A + N+ + R +D + + ++P A L+ + +S K H+A + H + L+ P +D + +PLH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL+K A I G TPLH+A ++V LL A+ D+ R +TPLH N+ D V +L+ GA + + +TPL +A+R +V ++++A
Sbjct: 197 ALHIAAKKDDTTAA-TLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLS--RGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAP---VDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQA 513 HSP 3 Score: 133.265 bits (334), Expect = 4.918e-32 Identity = 88/316 (27.85%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+AA GH ++L+ +G +V+ ++ ++PL A +G + L+ +GA+I R K +H AA +++ + + + + NG++P +A + V +A+ L+ V + H+A GH + LL++ D + + +PLH AC+ IK+VELL++ A + T +G TPLH+ +I++ L++ GA+ + + ++G TPLH+A +N +V +L+ N A +D QTPLH D V +LL GAN + + +PL +AA+
Sbjct: 229 TPLHIAAHYGHENVGQLLLEKG-ANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQG--APISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSA--------DPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAK 533 HSP 4 Score: 127.102 bits (318), Expect = 4.915e-30 Identity = 103/366 (28.14%), Postives = 170/366 (46.45%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKS-----PLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
E + E LH AAR N ++R +I+ A L +T LH+A+ G+ + IL+ + + + + +PL AA G EV L++ A + K+G +H+A++ + ++ + R +D + N ++P +A N A L+E K H+A K I + L++ K D + KS PLH + + G +I LLIE G+++ NG T +H+ Q+ + +L GA+IN + G TPLH+A +MV L++N AD+ TPLH +Q + V LL GA+ + TG+TPL +A R Y+S+V+ +
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQAREL-QTPLHIASRLGNTDIV-ILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLE--RGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--------KADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETL 807 HSP 5 Score: 121.324 bits (303), Expect = 3.742e-28 Identity = 90/354 (25.42%), Postives = 164/354 (46.33%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK---------------HRHFKLDDQD----------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +L+ + + +++ + G+TPL AA+ G + +V +L+++GA +G +H+AA N +++ + R H +L + D + SP +A + A L++ + D + L K HLA K G+ + LL+E P ++ K + +PLH A K+ LL+E GA+ NG+TPLHI +K+ +I L++ AD N ++ G TPLH++ + LL++N +D+ N T +H +++ +IL GA +++ G TPL +A ++MV +++
Sbjct: 394 TPLHIACKKNRIKVVELLL-KYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGK---NQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743 HSP 6 Score: 117.087 bits (292), Expect = 7.297e-27 Identity = 110/414 (26.57%), Postives = 173/414 (41.79%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKD----IDVSQL----------------------DKTNKNAW---HLACKNGHENIFNLLIEMEV-----------PKELMDK----------------LDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFAD---------------------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+LH+A+ +GH E R LI + + VD + G T L A+ G +V LVE GA ++ ++ G +++AA+ N +++Y+ + + L +D G +P +A+ + L+E D + + L D T+K+ + H+A GHEN+ LL+E P + K +DS K +PLH A +G ++V+LL+ QGA +S T NG PLH+ Q D + LL+ AD N + + G TPLHIA N +V LLL A ++ TPLH + V LL +GAN G+TPL +AAR + +V ++I+
Sbjct: 69 SLHLASKEGHSEVVRELI-KRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTED--GFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479 HSP 7 Score: 106.686 bits (265), Expect = 1.633e-23 Identity = 84/320 (26.25%), Postives = 144/320 (45.00%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
AA G +E L+ G ++ + G+ L A+ GH EVV+ L+++ A + ++G +HIA+ I+ + + + Q NG +P +A +N K L++ + + + +A + GH+ + +L+E DS K LH A + LL++ N + +GFTPLHI ++ LL++ GA++N Q +PLH+AT +M LLL A +D TPLH V++L+++GA +S K G PL MAA+G ++ ++
Sbjct: 40 AARAGDLEKVLELLRAG-TDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNV--QSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLEN----------DSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLL 346 HSP 8 Score: 83.9593 bits (206), Expect = 1.863e-16 Identity = 64/251 (25.50%), Postives = 110/251 (43.82%), Query Frame = 3
Query: 561 GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTP-----------------------------LHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
G + FL A + L+ D++ + N+ HLA K GH + LI+ + +D + LH A G IV +L+E GAN++ + NGFTPL++ Q++ +++ L+K GA+ G TP LHIA + + TLLL N + D+ + TPLH + ++LL +GAN++ + +PL +A + +M ++++
Sbjct: 33 GSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQA---QVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLL 280 HSP 9 Score: 75.0998 bits (183), Expect = 1.186e-13 Identity = 42/140 (30.00%), Postives = 84/140 (60.00%), Query Frame = 3
Query: 810 KIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
K++ELL G +++ NG LH+ +++ ++++ LIK A ++ +GNT LHIA+L+ +VT+L++N A++++ + TPL+ ++N + V+ LL GAN + + G TPL +A + + +V ++++
Sbjct: 48 KVLELL-RAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLE 186
BLAST of Death domain protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0334061) HSP 1 Score: 151.754 bits (382), Expect = 5.040e-38 Identity = 108/358 (30.17%), Postives = 173/358 (48.32%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR N ++R +++ A +T LH+A+ G+++ +L+ G VD K T L AA G EV L+E GA + K+G +H+ A+ + + + + +K +D Q NG++P +A N A L+EK K H+A + +I L+E L + + +PLH + + G +I LLIE A ++ P NG TP+H+ Q+ ++ +L K GA+I+ G TPLH+A+ +MV LL N A++D + TPLH +Q C V +LL AN + G+TPL +A + YIS++D +
Sbjct: 585 RGETPLHLAARANQTDIIRILLRNGAQVDARARE-QQTPLHIASRLGNVDIVMLLLQHG-AQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKE--ADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGA---LANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSL 935 HSP 2 Score: 145.591 bits (366), Expect = 5.209e-36 Identity = 89/322 (27.64%), Postives = 165/322 (51.24%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+AA + ++A L+ + + D+ K G TPL A+++G+ + L++KGA ++ K +H+AA+ N++ + K + + +D G++P A L+E+ +S K H+A + H + +L+ P +D++ + LH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL++ GA I+ G TPLH+A ++V LL ++A D+ R +TPLH N+ D + ILL GA + + +TPL +A+R + +V ++++
Sbjct: 325 ALHIAAKKDDVKAA-TLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRD--GLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAP---VDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQ 640 HSP 3 Score: 140.584 bits (353), Expect = 2.454e-34 Identity = 92/316 (29.11%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+A+ G+ +LI +G V+ K+ ++PL AA +G +V L+EKG I + + G +H AA +++ + R + + NG++P +A V +A+ L+ V ++ A H+A GH + LL++ D++ + +PLH AC+ +K+VELL+ GA++S T +G TPLH+ +I++ L++ A + ++G TPLH+A +N ++ +LL N A +D +QTPLH D V +LL GA + K T L +AA+
Sbjct: 357 TPLHIASHYGNQNIANLLIQKG-ADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLE--RGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNA--------DANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAK 661 HSP 4 Score: 139.813 bits (351), Expect = 4.485e-34 Identity = 95/325 (29.23%), Postives = 162/325 (49.85%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
+ LH+AA G +L+ +G +++ + G+TPL AA GH +VV L+E+GA IS + K G +H+AA+G V+ + HR +D+ + ++ +A V AK L++++ D + H+ACK + LL+ + S +PLH A G + IV L++ A+ PT G TPLH+ + + DII +L++ GA ++ + + TPLHIA+ +V LLL + A +D T LH ++ + + +L+ GA L K G TPL + A+ +I + ++++ E
Sbjct: 390 SPLHVAAKWGKTNMVSLLLEKGG-NIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLY-HR-APVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGAS---ISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKE 708 HSP 5 Score: 124.79 bits (312), Expect = 3.225e-29 Identity = 90/323 (27.86%), Postives = 154/323 (47.68%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G + I + + S D+P G TPL AA ++++ L+ GA + R ++ +HIA+ V+I+ + + ++D + + +A + A LIE + K HL K GH + LL++ E +D + +PLH AC ++ LL+E+GA+ NG TPLHI +K+ DI L++ GA N ++ G TPLH+++ + LL+++ A ++ TP+H +++ + EIL GAN+ K G TPL +A+ +MV +++
Sbjct: 555 TPLHVAAFMGCMNIV-IYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQ--HGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEAD---VDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQ 871 HSP 6 Score: 121.324 bits (303), Expect = 3.910e-28 Identity = 86/323 (26.63%), Postives = 157/323 (48.61%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRIL-IFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T+ AA G++E R+L + + ++ + G+ L A+ GH+ VV L+ +GA++ K+G +HIA+ +++ + + ++ Q NG +P +A +N + L+ + S + +A + GH+ + +L+E + ++ +L + LH A + +K LL++ N + +GFTPLHI + +I LLI+ GAD+N +PLH+A +MV+LLL+ +++ TPLH V++LL RGA +S K G PL MAA+G ++ +++
Sbjct: 163 TSFLRAARAGNLE--RVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLE--HNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKV--RLPA-----LHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILL 474 HSP 7 Score: 86.2705 bits (212), Expect = 3.982e-17 Identity = 68/266 (25.56%), Postives = 124/266 (46.62%), Query Frame = 3
Query: 522 KHRHFKLDDQDY-NGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSN------------------LPSM-----------VTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
KH H Q +G + FL A + ++ +ID++ + NA HLA K+GH ++ + L+ ++D + LH A G ++V+LL+E A+++ + NGFTPL++ Q++ ++ LL+ GA+ + G TPL +A LP++ TLLLDN+ + D+ + TPLH + +L+ +GA+++ K +PL +AA+ +MV ++++
Sbjct: 147 KHEHCPTGHQSAGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGA---IVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLE 409 HSP 8 Score: 70.0922 bits (170), Expect = 4.488e-12 Identity = 38/124 (30.65%), Postives = 72/124 (58.06%), Query Frame = 3
Query: 864 NGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
NG LH+ ++ ++ L++ GA ++ +GNT LHIA+L+ +V LLL++NA +++ + TPL+ ++N V +LL GAN S + G TPL +A + + +V ++++++
Sbjct: 193 NGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESD 316
BLAST of Death domain protein vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303119) HSP 1 Score: 150.599 bits (379), Expect = 1.064e-37 Identity = 108/358 (30.17%), Postives = 173/358 (48.32%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR N ++R +++ A +T LH+A+ G+++ +L+ G VD K T L AA G EV L+E GA + K+G +H+ A+ + + + + +K +D Q NG++P +A N A L+EK K H+A + +I L+E L + + +PLH + + G +I LLIE A ++ P NG TP+H+ Q+ ++ +L K GA+I+ G TPLH+A+ +MV LL N A++D + TPLH +Q C V +LL AN + G+TPL +A + YIS++D +
Sbjct: 435 RGETPLHLAARANQTDIIRILLRNGAQVDARARE-QQTPLHIASRLGNVDIVMLLLQHG-AQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKE--ADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGA---LANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSL 785 HSP 2 Score: 145.591 bits (366), Expect = 5.279e-36 Identity = 89/322 (27.64%), Postives = 165/322 (51.24%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+AA + ++A L+ + + D+ K G TPL A+++G+ + L++KGA ++ K +H+AA+ N++ + K + + +D G++P A L+E+ +S K H+A + H + +L+ P +D++ + LH A G +++ +LL+++ A+ + NGFTPLHI +K+ ++ LL++ GA I+ G TPLH+A ++V LL ++A D+ R +TPLH N+ D + ILL GA + + +TPL +A+R + +V ++++
Sbjct: 175 ALHIAAKKDDVKAA-TLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRD--GLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAP---VDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQ 490 HSP 3 Score: 140.198 bits (352), Expect = 3.091e-34 Identity = 92/316 (29.11%), Postives = 156/316 (49.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
T LH+A+ G+ +LI +G V+ K+ ++PL AA +G +V L+EKG I + + G +H AA +++ + R + + NG++P +A V +A+ L+ V ++ A H+A GH + LL++ D++ + +PLH AC+ +K+VELL+ GA++S T +G TPLH+ +I++ L++ A + ++G TPLH+A +N ++ +LL N A +D +QTPLH D V +LL GA + K T L +AA+
Sbjct: 207 TPLHIASHYGNQNIANLLIQKG-ADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLE--RGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNA--------DANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAK 511 HSP 4 Score: 139.428 bits (350), Expect = 4.937e-34 Identity = 95/325 (29.23%), Postives = 162/325 (49.85%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
+ LH+AA G +L+ +G +++ + G+TPL AA GH +VV L+E+GA IS + K G +H+AA+G V+ + HR +D+ + ++ +A V AK L++++ D + H+ACK + LL+ + S +PLH A G + IV L++ A+ PT G TPLH+ + + DII +L++ GA ++ + + TPLHIA+ +V LLL + A +D T LH ++ + + +L+ GA L K G TPL + A+ +I + ++++ E
Sbjct: 240 SPLHVAAKWGKTNMVSLLLEKGG-NIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLY-HR-APVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGAS---ISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKE 558 HSP 5 Score: 124.02 bits (310), Expect = 4.821e-29 Identity = 90/323 (27.86%), Postives = 152/323 (47.06%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G + I + + S D+P G TPL AA ++++ L+ GA + R ++ +HIA+ V+I+ + + +D + +A + A LIE + K HL K GH + LL++ E +D + +PLH AC ++ LL+E+GA+ NG TPLHI +K+ DI L++ GA N ++ G TPLH+++ + LL+++ A ++ TP+H +++ + EIL GAN+ K G TPL +A+ +MV +++
Sbjct: 405 TPLHVAAFMGCMNIV-IYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDM--YTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEAD---VDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQ 721 HSP 6 Score: 120.939 bits (302), Expect = 5.163e-28 Identity = 86/323 (26.63%), Postives = 156/323 (48.30%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILI-FEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T+ AA G++E R+L + + ++ + G+ L A+ GH+ VV L+ +GA++ K+G +HIA+ +++ + + + Q NG +P +A +N + L+ + S + +A + GH+ + +L+E + ++ +L + LH A + +K LL++ N + +GFTPLHI + +I LLI+ GAD+N +PLH+A +MV+LLL+ +++ TPLH V++LL RGA +S K G PL MAA+G ++ +++
Sbjct: 13 TSFLRAARAGNLE--RVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQ--NGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKV--RLPA-----LHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILL 324 HSP 7 Score: 83.1889 bits (204), Expect = 3.724e-16 Identity = 64/253 (25.30%), Postives = 120/253 (47.43%), Query Frame = 3
Query: 558 NGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSN------------------LPSM-----------VTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+G + FL A + ++ +ID++ + NA HLA K+GH ++ + L+ ++D + LH A G ++V+LL+E A+++ + NGFTPL++ Q++ ++ LL+ GA+ + G TPL +A LP++ TLLLDN+ + D+ + TPLH + +L+ +GA+++ K +PL +AA+ +MV ++++
Sbjct: 10 DGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGA---IVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLE 259 HSP 8 Score: 69.707 bits (169), Expect = 6.058e-12 Identity = 38/131 (29.01%), Postives = 75/131 (57.25%), Query Frame = 3
Query: 843 NLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
+++ NG LH+ ++ ++ L++ GA ++ +GNT LHIA+L+ +V LLL++NA +++ + TPL+ ++N V +LL GAN S + G TPL +A + + +V ++++++
Sbjct: 36 DINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESD 166
BLAST of Death domain protein vs. Ensembl Fly
Match: Ank (gene:FBgn0011747 transcript:FBtr0089172) HSP 1 Score: 149.443 bits (376), Expect = 3.250e-37 Identity = 96/322 (29.81%), Postives = 173/322 (53.73%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+AA + + A ++L+ + + DI K G TPL AA++G++++ L+ A ++ K +H+A + +++ + R K+D +G++P A V K L++++ + K +A H+A + H+ +LL++ + P +D++ + LH A G +K+ +LL++ AN + NGFTPLHI +K+ ++ LLIK GA+I G TPLH+A+ ++V LL + A D+ R +TPLH N+ D + I LLR A + I + G+TPL +A+R I+++ ++++
Sbjct: 204 ALHIAAKKNDVNAAKLLL-QHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC--RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAP---VDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRI-LLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQ 518 HSP 2 Score: 139.813 bits (351), Expect = 4.072e-34 Identity = 98/325 (30.15%), Postives = 170/325 (52.31%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE--MEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+AA GH++ ++L+ + K + + G TPL A +++V+ L++ GA I + G +H+A+ +NI+ Y+ + D G +P LA N + L+ + V + + + H+A + G+ NI LL++ E+ + DK S LH A + G IV++L+E GA + T GFTPLH+ + +++ +L++ GA I+ Q TPLH+AT N PS+V LLL N + ++ Q +H ++N + LL GA+++ I K+G +PL +AA+G + MV ++++
Sbjct: 368 TALHVAAHCGHVKVAKLLL-DYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQ--HEASADLPTIRGETPLHLAARANQADIIRILL-RSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKY-----SALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLE 683 HSP 3 Score: 128.642 bits (322), Expect = 2.019e-30 Identity = 90/323 (27.86%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +LI G ++ + G+TPL A++ G + +V +L++ A +G +H+AA N +I+ + R K+D G +P +A + L++ +++ +A H+A K G ENI +L+E + K +PLH AC+ G +V++L++ GA++ N TPLH+ T + I+ LL+K G+ N G +HIA N + LL + AD++II+ +PLH + D V++LL G +S K G TPL +AA+ ++ + ++++
Sbjct: 401 TPLHIACKKNRIKMVELLIKHG-ANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRS---AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK---KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLE 715 HSP 4 Score: 127.872 bits (320), Expect = 3.181e-30 Identity = 93/319 (29.15%), Postives = 154/319 (48.28%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVD 1217
+ALH+AA +G ++L+ G + + K G TPL A +G VVQ L++ GA I + K +H+A N +I+E + + NG SP L A + C A H+ACK + I L++ ++ K S SPLH A + G + +V+LL+E G +S NG TPLH+ Q+ + +L++ GA+I+ + G TPLH+A +V ++N+AD+++ +N TPLH +Q + +LL AN + + K G T L +A+ Y+++++
Sbjct: 532 SALHIAAKEGQENIVQVLLENGAENNAVTKK-GFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK------------NGSSPNLCARNGQC-----------------------AIHIACKKNYLEIAMQLLQHGADVNIISK---SGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVME 810 HSP 5 Score: 111.694 bits (278), Expect = 4.825e-25 Identity = 93/328 (28.35%), Postives = 158/328 (48.17%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T L+MAA + H R L+ G + + + G TPL A GH ++V L+E R K +HIAA+ N VN + + + + D +G +P +A V A L+ DV+ + K N H+ACK G ++ LL+ K+D++ + +PLH A +G +++++ L++Q A + T NG + LH+ Q + LL+ A ++ + T LH+A + LLLD A+ + TPLH ++N+ VE+L+ GAN+ ++G TPL +A+ I++V +++ E
Sbjct: 141 TPLYMAAQENHDNCCRTLLANG-ANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDV----RGKVRLPALHIAAKKNDVNAAKLLLQHDPN--ADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGA------KIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHE 455 HSP 6 Score: 107.457 bits (267), Expect = 1.097e-23 Identity = 80/323 (24.77%), Postives = 153/323 (47.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA + RIL+ KV D + G TPL A+ G++ ++ L++ GA I+ ++ +HIAA+ NI++ + + G +P LA + L++ + K + H+A + +I LL++ L + + + +H AC+ +++I L++ GA+++ + +GF+PLH+ Q D++ LL++ G I+ G TPLH+A + +LL++ A++ TPLH D V+ + A++ G TPL AA+ +I +++++++
Sbjct: 467 TPLHLAARANQADIIRILLRSAKV--DAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK--KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCAR---NGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLR 781 HSP 7 Score: 95.5153 bits (236), Expect = 5.538e-20 Identity = 81/310 (26.13%), Postives = 142/310 (45.81%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVS-VDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSY 1202
AA G I+ + G++S ++ + G+ L AA G++++ L+ +G I K+G +HIA+ +++ + + + + Q NG +P +A +N + L+ + S + +A + GH+ I +L+E +V ++ +L + LH A + + +LL++ N + +GFTPLHI DI LL+ AD+N TPLH+A S+ TLLL A +D TPLH + ++ LL + A + K G + L MAA+G +
Sbjct: 45 AARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNV--QSLNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKV--RLPA-----LHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEH 345 HSP 8 Score: 80.4925 bits (197), Expect = 2.919e-15 Identity = 70/296 (23.65%), Postives = 122/296 (41.22%), Query Frame = 3
Query: 435 ISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI--EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGA----------------DINCQNM-------------QGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
I K+N + A G+ +++++ ++ + NG++ LA V L+ + I + K A H+A G ++ N LI V + ++ +PL+ A + L+ GAN S T +GFTPL + Q+ I+ +L++ D+N + G TPLHIA + TLLL+N AD++ + TPLH + K +LL RGA + + G TPL A+R ++ ++ +++
Sbjct: 32 IIKQNDATISFLRAARSGDIKKVMDFLDCGEIS-DINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGF-----TPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQ 321
BLAST of Death domain protein vs. Ensembl Fly
Match: Ank (gene:FBgn0011747 transcript:FBtr0300497) HSP 1 Score: 149.443 bits (376), Expect = 3.250e-37 Identity = 96/322 (29.81%), Postives = 173/322 (53.73%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+AA + + A ++L+ + + DI K G TPL AA++G++++ L+ A ++ K +H+A + +++ + R K+D +G++P A V K L++++ + K +A H+A + H+ +LL++ + P +D++ + LH A G +K+ +LL++ AN + NGFTPLHI +K+ ++ LLIK GA+I G TPLH+A+ ++V LL + A D+ R +TPLH N+ D + I LLR A + I + G+TPL +A+R I+++ ++++
Sbjct: 204 ALHIAAKKNDVNAAKLLL-QHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC--RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAP---VDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRI-LLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQ 518 HSP 2 Score: 139.813 bits (351), Expect = 4.072e-34 Identity = 98/325 (30.15%), Postives = 170/325 (52.31%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE--MEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+AA GH++ ++L+ + K + + G TPL A +++V+ L++ GA I + G +H+A+ +NI+ Y+ + D G +P LA N + L+ + V + + + H+A + G+ NI LL++ E+ + DK S LH A + G IV++L+E GA + T GFTPLH+ + +++ +L++ GA I+ Q TPLH+AT N PS+V LLL N + ++ Q +H ++N + LL GA+++ I K+G +PL +AA+G + MV ++++
Sbjct: 368 TALHVAAHCGHVKVAKLLL-DYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQ--HEASADLPTIRGETPLHLAARANQADIIRILL-RSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKY-----SALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLE 683 HSP 3 Score: 128.642 bits (322), Expect = 2.019e-30 Identity = 90/323 (27.86%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +LI G ++ + G+TPL A++ G + +V +L++ A +G +H+AA N +I+ + R K+D G +P +A + L++ +++ +A H+A K G ENI +L+E + K +PLH AC+ G +V++L++ GA++ N TPLH+ T + I+ LL+K G+ N G +HIA N + LL + AD++II+ +PLH + D V++LL G +S K G TPL +AA+ ++ + ++++
Sbjct: 401 TPLHIACKKNRIKMVELLIKHG-ANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRS---AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK---KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLE 715 HSP 4 Score: 127.872 bits (320), Expect = 3.181e-30 Identity = 93/319 (29.15%), Postives = 154/319 (48.28%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVD 1217
+ALH+AA +G ++L+ G + + K G TPL A +G VVQ L++ GA I + K +H+A N +I+E + + NG SP L A + C A H+ACK + I L++ ++ K S SPLH A + G + +V+LL+E G +S NG TPLH+ Q+ + +L++ GA+I+ + G TPLH+A +V ++N+AD+++ +N TPLH +Q + +LL AN + + K G T L +A+ Y+++++
Sbjct: 532 SALHIAAKEGQENIVQVLLENGAENNAVTKK-GFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK------------NGSSPNLCARNGQC-----------------------AIHIACKKNYLEIAMQLLQHGADVNIISK---SGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVME 810 HSP 5 Score: 111.694 bits (278), Expect = 4.825e-25 Identity = 93/328 (28.35%), Postives = 158/328 (48.17%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T L+MAA + H R L+ G + + + G TPL A GH ++V L+E R K +HIAA+ N VN + + + + D +G +P +A V A L+ DV+ + K N H+ACK G ++ LL+ K+D++ + +PLH A +G +++++ L++Q A + T NG + LH+ Q + LL+ A ++ + T LH+A + LLLD A+ + TPLH ++N+ VE+L+ GAN+ ++G TPL +A+ I++V +++ E
Sbjct: 141 TPLYMAAQENHDNCCRTLLANG-ANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDV----RGKVRLPALHIAAKKNDVNAAKLLLQHDPN--ADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGA------KIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHE 455 HSP 6 Score: 107.457 bits (267), Expect = 1.097e-23 Identity = 80/323 (24.77%), Postives = 153/323 (47.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA + RIL+ KV D + G TPL A+ G++ ++ L++ GA I+ ++ +HIAA+ NI++ + + G +P LA + L++ + K + H+A + +I LL++ L + + + +H AC+ +++I L++ GA+++ + +GF+PLH+ Q D++ LL++ G I+ G TPLH+A + +LL++ A++ TPLH D V+ + A++ G TPL AA+ +I +++++++
Sbjct: 467 TPLHLAARANQADIIRILLRSAKV--DAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK--KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCAR---NGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLR 781 HSP 7 Score: 95.5153 bits (236), Expect = 5.538e-20 Identity = 81/310 (26.13%), Postives = 142/310 (45.81%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVS-VDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSY 1202
AA G I+ + G++S ++ + G+ L AA G++++ L+ +G I K+G +HIA+ +++ + + + + Q NG +P +A +N + L+ + S + +A + GH+ I +L+E +V ++ +L + LH A + + +LL++ N + +GFTPLHI DI LL+ AD+N TPLH+A S+ TLLL A +D TPLH + ++ LL + A + K G + L MAA+G +
Sbjct: 45 AARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNV--QSLNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKV--RLPA-----LHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEH 345 HSP 8 Score: 80.4925 bits (197), Expect = 2.919e-15 Identity = 70/296 (23.65%), Postives = 122/296 (41.22%), Query Frame = 3
Query: 435 ISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI--EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGA----------------DINCQNM-------------QGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
I K+N + A G+ +++++ ++ + NG++ LA V L+ + I + K A H+A G ++ N LI V + ++ +PL+ A + L+ GAN S T +GFTPL + Q+ I+ +L++ D+N + G TPLHIA + TLLL+N AD++ + TPLH + K +LL RGA + + G TPL A+R ++ ++ +++
Sbjct: 32 IIKQNDATISFLRAARSGDIKKVMDFLDCGEIS-DINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGF-----TPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQ 321
BLAST of Death domain protein vs. Ensembl Fly
Match: Ank (gene:FBgn0011747 transcript:FBtr0089171) HSP 1 Score: 149.443 bits (376), Expect = 3.250e-37 Identity = 96/322 (29.81%), Postives = 173/322 (53.73%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+AA + + A ++L+ + + DI K G TPL AA++G++++ L+ A ++ K +H+A + +++ + R K+D +G++P A V K L++++ + K +A H+A + H+ +LL++ + P +D++ + LH A G +K+ +LL++ AN + NGFTPLHI +K+ ++ LLIK GA+I G TPLH+A+ ++V LL + A D+ R +TPLH N+ D + I LLR A + I + G+TPL +A+R I+++ ++++
Sbjct: 204 ALHIAAKKNDVNAAKLLL-QHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC--RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAP---VDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRI-LLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQ 518 HSP 2 Score: 139.813 bits (351), Expect = 4.072e-34 Identity = 98/325 (30.15%), Postives = 170/325 (52.31%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE--MEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+AA GH++ ++L+ + K + + G TPL A +++V+ L++ GA I + G +H+A+ +NI+ Y+ + D G +P LA N + L+ + V + + + H+A + G+ NI LL++ E+ + DK S LH A + G IV++L+E GA + T GFTPLH+ + +++ +L++ GA I+ Q TPLH+AT N PS+V LLL N + ++ Q +H ++N + LL GA+++ I K+G +PL +AA+G + MV ++++
Sbjct: 368 TALHVAAHCGHVKVAKLLL-DYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQ--HEASADLPTIRGETPLHLAARANQADIIRILL-RSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKY-----SALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLE 683 HSP 3 Score: 128.642 bits (322), Expect = 2.019e-30 Identity = 90/323 (27.86%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I+ +LI G ++ + G+TPL A++ G + +V +L++ A +G +H+AA N +I+ + R K+D G +P +A + L++ +++ +A H+A K G ENI +L+E + K +PLH AC+ G +V++L++ GA++ N TPLH+ T + I+ LL+K G+ N G +HIA N + LL + AD++II+ +PLH + D V++LL G +S K G TPL +AA+ ++ + ++++
Sbjct: 401 TPLHIACKKNRIKMVELLIKHG-ANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRS---AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK---KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLE 715 HSP 4 Score: 127.872 bits (320), Expect = 3.181e-30 Identity = 93/319 (29.15%), Postives = 154/319 (48.28%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVD 1217
+ALH+AA +G ++L+ G + + K G TPL A +G VVQ L++ GA I + K +H+A N +I+E + + NG SP L A + C A H+ACK + I L++ ++ K S SPLH A + G + +V+LL+E G +S NG TPLH+ Q+ + +L++ GA+I+ + G TPLH+A +V ++N+AD+++ +N TPLH +Q + +LL AN + + K G T L +A+ Y+++++
Sbjct: 532 SALHIAAKEGQENIVQVLLENGAENNAVTKK-GFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK------------NGSSPNLCARNGQC-----------------------AIHIACKKNYLEIAMQLLQHGADVNIISK---SGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVME 810 HSP 5 Score: 111.694 bits (278), Expect = 4.825e-25 Identity = 93/328 (28.35%), Postives = 158/328 (48.17%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T L+MAA + H R L+ G + + + G TPL A GH ++V L+E R K +HIAA+ N VN + + + + D +G +P +A V A L+ DV+ + K N H+ACK G ++ LL+ K+D++ + +PLH A +G +++++ L++Q A + T NG + LH+ Q + LL+ A ++ + T LH+A + LLLD A+ + TPLH ++N+ VE+L+ GAN+ ++G TPL +A+ I++V +++ E
Sbjct: 141 TPLYMAAQENHDNCCRTLLANG-ANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDV----RGKVRLPALHIAAKKNDVNAAKLLLQHDPN--ADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGA------KIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHE 455 HSP 6 Score: 107.457 bits (267), Expect = 1.097e-23 Identity = 80/323 (24.77%), Postives = 153/323 (47.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA + RIL+ KV D + G TPL A+ G++ ++ L++ GA I+ ++ +HIAA+ NI++ + + G +P LA + L++ + K + H+A + +I LL++ L + + + +H AC+ +++I L++ GA+++ + +GF+PLH+ Q D++ LL++ G I+ G TPLH+A + +LL++ A++ TPLH D V+ + A++ G TPL AA+ +I +++++++
Sbjct: 467 TPLHLAARANQADIIRILLRSAKV--DAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK--KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCAR---NGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLR 781 HSP 7 Score: 95.5153 bits (236), Expect = 5.538e-20 Identity = 81/310 (26.13%), Postives = 142/310 (45.81%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVS-VDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSY 1202
AA G I+ + G++S ++ + G+ L AA G++++ L+ +G I K+G +HIA+ +++ + + + + Q NG +P +A +N + L+ + S + +A + GH+ I +L+E +V ++ +L + LH A + + +LL++ N + +GFTPLHI DI LL+ AD+N TPLH+A S+ TLLL A +D TPLH + ++ LL + A + K G + L MAA+G +
Sbjct: 45 AARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNV--QSLNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKV--RLPA-----LHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEH 345 HSP 8 Score: 80.4925 bits (197), Expect = 2.919e-15 Identity = 70/296 (23.65%), Postives = 122/296 (41.22%), Query Frame = 3
Query: 435 ISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI--EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGA----------------DINCQNM-------------QGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
I K+N + A G+ +++++ ++ + NG++ LA V L+ + I + K A H+A G ++ N LI V + ++ +PL+ A + L+ GAN S T +GFTPL + Q+ I+ +L++ D+N + G TPLHIA + TLLL+N AD++ + TPLH + K +LL RGA + + G TPL A+R ++ ++ +++
Sbjct: 32 IIKQNDATISFLRAARSGDIKKVMDFLDCGEIS-DINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGF-----TPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQ 321
BLAST of Death domain protein vs. Ensembl Zebrafish
Match: ankdd1a (ankyrin repeat and death domain containing 1A [Source:ZFIN;Acc:ZDB-GENE-070615-8]) HSP 1 Score: 262.692 bits (670), Expect = 2.438e-80 Identity = 172/523 (32.89%), Postives = 272/523 (52.01%), Query Frame = 3
Query: 144 LSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGV-ESQDTPVRGLYEALVSIGRRKLADKIRR 1709
L ++E H+AA++ND ++++I + DR ALH AA G +A R+L+ + VD D +GM LL AA+FGHL +++ LV GA ++ NK G +++H AA+ + ILEY+ + +L+ + +G + F LA + + LI + DK A HLA K GH ++ ++E E +D+ + + LH A E G + + LL+E G N+++ T + T LH+V Q + A + LLI+AG +++ + Q + LH+A L+N +V L++ D+DI +NR QT LH E + + E +L+ G NL+ +DK GK+ L +AARG+++++VDMIIK +D F Y ++ +QP + + LWK+A L+ EWK LA +W F HI AIE+Q T SYK HG+R+L IW HGV + + P++GLYE L+ I R LA+ +R+
Sbjct: 12 LLRSEKEFHDAAKRNDTERMQELISRGVDIKVKNKM-DRKALHWAAGAGSEQALRLLLDH-DMDVDDMDSFGMNALLLAAWFGHLTILKILVSTGAKLTTENKNGLNLLHCAAQRGHITILEYIMEDLENVQLNKVENSGKTAFHLAAEHGHLEVVEFLIGMGCAHNLKDKHGNTALHLAAKQGHSDVLQKIME---TGENIDERNIDGMTALHLASEGGHYECIRLLLEAGCNVNELTDSKRTALHLVAQHASASEVRLLIQAGINLDSVDTQHVSALHLAVLNNSTEIVKDLIEAGCDLDIFDNRLQTALHIAAEHGRLNIAETILISGVNLNLLDKQGKSSLDVAARGNHVNVVDMIIK------------------------------------ADRF-------------------YKWEKDHQPETQHIRSVLWKLASRFLKPGEWKTLARHWKFSEAHIRAIEHQWTGTKSYKEHGHRMLLIWLHGVITAGENPIKGLYEGLMGISRVDLAESMRQ 474
BLAST of Death domain protein vs. Ensembl Zebrafish
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:ZFIN;Acc:ZDB-GENE-060526-136]) HSP 1 Score: 242.662 bits (618), Expect = 6.221e-73 Identity = 151/488 (30.94%), Postives = 257/488 (52.66%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLD--KTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLADKIRRE 1712
RTALH A + ++EA +L+ + +D+ DK+G+T + AA+FG LE+++ LV+ GA S N +G +++H AA N +I+ Y+ + +LD +D G PF+LA + CV + L+E+ +++ ++ + HLA K+G LL+E + ++++ + ++ L+ A + V+ L+E + + T + +PLH V ++ I+ LLI +GA IN QN Q T H+A + ++ LL+ D ++ ++ QT LH E K D VE++L G +L D+ KT L +AARG+ + +VDMIIKAER+ F+ D + ++ + + K + P + + +W +A+ +L+ ++WKKLA +W F + AIE Q T NS++ HG R+L IW HG+ + +P +GLYE L++ G K+A+KIR E
Sbjct: 18 RTALHYAVACRNVEAVDVLLRR-RAKLDLQDKHGLTAVHLAAWFGSLEILKLLVQGGADQSIENTEGLNMLHCAAMNNHTDIVAYIIDDLQMGELDKEDQFGNRPFVLAAAHGCVPMLQMLMEEHYNMATMEENQVGDTPLHLAAKHGQREALQLLLE---NFHIRNEVNQAGQTALYLAADGAHEDCVQTLLEAQCDPNIFTLSRNSPLHPVCERGHFQIVQLLINSGAQINAQNQQMQTSFHLAVRNCHIPVIHTLLEAGCDPNLTDHMGQTALHIAAEMGKVDVVEMILKAGVDLQIRDRQNKTALGVAARGNMVIIVDMIIKAERY-----------------------------FKWKDNLQI----------SLHSESPLTFKLDHSPDTKPVRDIMWDLAYKHLKRNDWKKLAEHWEFTDAQMAAIEEQWTGLNSFQEHGNRMLLIWLHGILIEESSPSKGLYEGLLASGNTKVAEKIRME 462 HSP 2 Score: 50.447 bits (119), Expect = 4.428e-6 Identity = 36/142 (25.35%), Postives = 66/142 (46.48%), Query Frame = 3
Query: 825 LIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILL--LRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFN 1244
L+ +G N++ +G T LH + + +L++ A ++ Q+ G T +H+A ++ LL+ AD I N LH N D V ++ L+ L D+ G P ++AA + M+ M+++ E +N
Sbjct: 3 LLGRGVNVNAKNVHGRTALHYAVACRNVEAVDVLLRRRAKLDLQDKHGLTAVHLAAWFGSLEILKLLVQGGADQSIENTEGLNMLHCAAMNNHTDIVAYIIDDLQMGELDKEDQFGNRPFVLAAAHGCVPMLQMLME-EHYN 143
BLAST of Death domain protein vs. Ensembl Zebrafish
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:ZFIN;Acc:ZDB-GENE-060526-136]) HSP 1 Score: 192.971 bits (489), Expect = 4.693e-55 Identity = 131/456 (28.73%), Postives = 223/456 (48.90%), Query Frame = 3
Query: 354 YGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLD--KTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLADKIRRE 1712
+G+T + AA+FG LE+++ LV+ GA S +E F G PF+LA + CV + L+E+ +++ ++ + HLA K+G LL+E + ++++ + ++ L+ A + V+ L+E + + T + +PLH V ++ I+ LLI +GA IN QN Q T H+A + ++ LL+ D ++ ++ QT LH E K D VE++L G +L D+ KT L +AARG+ + +VDMIIKAER+ F+ D + N ++ +++ + + K + P + + +W +A+ +L+ ++WKKLA +W F + AIE Q T NS++ HG R+L IW HG+ + +P +GLYE L++ G K+A+KIR E
Sbjct: 1 HGLTAVHLAAWFGSLEILKLLVQGGADQS---------------------IENTF--------------GNRPFVLAAAHGCVPMLQMLMEEHYNMATMEENQVGDTPLHLAAKHGQREALQLLLE---NFHIRNEVNQAGQTALYLAADGAHEDCVQTLLEAQCDPNIFTLSRNSPLHPVCERGHFQIVQLLINSGAQINAQNQQMQTSFHLAVRNCHIPVIHTLLEAGCDPNLTDHMGQTALHIAAEMGKVDVVEMILKAGVDLQIRDRQNKTALGVAARGNMVIIVDMIIKAERY-----------------------------FKWKDNLQITNT---DAIESLHSESPLTFKLDHSPDTKPVRDIMWDLAYKHLKRNDWKKLAEHWEFTDAQMAAIEEQWTGLNSFQEHGNRMLLIWLHGILIEESSPSKGLYEGLLASGNTKVAEKIRME 386 HSP 2 Score: 67.781 bits (164), Expect = 1.302e-11 Identity = 57/253 (22.53%), Postives = 110/253 (43.48%), Query Frame = 3
Query: 273 MAASQGHIEATRILIFEG-KVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLL 1028
+AA+ G + ++L+ E ++ ++ G TPL AA G E +Q L+E + ++ N+ G +++AA+G ++CV + L+E D + + + H C+ GH I LLI ++ + ++ H A N I ++ L+E G + + G T LHI + D++ +++KAG D+ ++ Q T L +A N+ +V +++
Sbjct: 41 LAAAHGCVPMLQMLMEEHYNMATMEENQVGDTPLHLAAKHGQREALQLLLENFHIRNEVNQAGQTALYLAADG--------------------------------AHEDCV---QTLLEAQCDPNIFTLSRNSPLHPVCERGHFQIVQLLINSGAQ---INAQNQQMQTSFHLAVRNCHIPVIHTLLEAGCDPNLTDHMGQTALHIAAEMGKVDVVEMILKAGVDLQIRDRQNKTALGVAARGNMVIIVDMII 255 HSP 3 Score: 53.5286 bits (127), Expect = 4.976e-7 Identity = 29/97 (29.90%), Postives = 51/97 (52.58%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDD 548
+T+ H+A HI L+ E ++ D G T L AA G ++VV+ +++ G + R++Q + +AA GN V I++ + + R+FK D
Sbjct: 170 QTSFHLAVRNCHIPVIHTLL-EAGCDPNLTDHMGQTALHIAAEMGKVDVVEMILKAGVDLQIRDRQNKTALGVAARGNMVIIVDMIIKAERYFKWKD 265
BLAST of Death domain protein vs. Ensembl Zebrafish
Match: ank3b (ankyrin 3b [Source:ZFIN;Acc:ZDB-GENE-060621-2]) HSP 1 Score: 148.673 bits (374), Expect = 5.136e-38 Identity = 100/328 (30.49%), Postives = 163/328 (49.70%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T LH+AA G+I +L+ G +VD + +TPL A+ G+ +V+ L+E+GA I R K G +H A ++E + R + + NG+SP +A + + + LI ++ V + A H+A GH +V K L+DK + + +PLH AC+ IK++ELL++ GA++ T +G TP+H+ +I+ L GA N N++G T LH+A + ++V L+ N AD+D +QTPLH K D V+ LL GA + +G TPL +AAR + + +++
Sbjct: 208 TPLHIAAHYGNINVATLLLNRG-AAVDFKARNDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLD--RGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVPVDDVTNDYLTALHVAAHCGH---------YKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSRLGKPDIVQQLLQHGALPDSTTTSGYTPLHLAARDGHKDVASILL 523 HSP 2 Score: 137.887 bits (346), Expect = 3.341e-34 Identity = 87/310 (28.06%), Postives = 159/310 (51.29%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
ALH+AA + +A +L+ + + DI K G TPL AA++G++ V L+ +GA + + + +H+A++ N++ + R ++D + +G++P + L+++ + K + H+A + H N LLI EVP +D + + + LH A G K+ ++L+++ AN + NGFTPLHI +K+ ++ LL+K GA I G TP+H+A ++VT L ++ A + +N R +T LH + + V+ L+ GA++ K +TPL +++R
Sbjct: 176 ALHIAARKDDTKAAALLL-QNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKARNDITPLHVASKRGNANMVRLLLE--RGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVP---VDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSR 479 HSP 3 Score: 125.946 bits (315), Expect = 3.491e-30 Identity = 93/320 (29.06%), Postives = 157/320 (49.06%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
AA G+IE I G V ++I ++ G+ L A+ GH+EVV L++ GA + K+G +HIA+ ++++ + ++ Q NG +P +A +N + K L++ S + +A + GH+ + +LL+E + ++ +L + LH A K LL++ N + +GFTPLHI ++ LL+ GA ++ + TPLH+A+ +MV LLL+ A +D TPLH G VE+LL RGA + + K G +PL MA +G +++ V ++I E
Sbjct: 19 AARAGNIEKALDYIKTG-VDINICNQNGLNALHLASKEGHVEVVTELIKLGATVDAATKKGNTALHIASLAGQADVVKELVNNG--ANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV--RLPA-----LHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKARNDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHE 328 HSP 4 Score: 121.709 bits (304), Expect = 8.011e-29 Identity = 85/298 (28.52%), Postives = 140/298 (46.98%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLS 1148
D T LH+A+ +G+ R+L+ G +D K G+TPL A GH +VV+ L+++GA I + K G +H+A +G+ +N ++ + H +DD + ++ +A AK L++K + + H+ACK + LL++ + + S +P+H A G IV L GA+ + G T LH+ + A+++ L+ GAD++ + TPLHI++ P +V LL + A D TPLH D ILL GA+L
Sbjct: 239 DITPLHVASKRGNANMVRLLLERG-ARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLI--HHEVPVDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS---IQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSRLGKPDIVQQLLQHGALPDSTTTSGYTPLHLAARDGHKDVASILLDNGASLG 530 HSP 5 Score: 114.775 bits (286), Expect = 1.597e-26 Identity = 90/351 (25.64%), Postives = 166/351 (47.29%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVS-----------------------------KNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+A+ +GH+E LI G +VD K G T L A+ G +VV+ LV GA I+ +++ G +++AA+ N +++++++ + +D G +P +A+ K+ +A L++ D + K+ H+A G+ N+ LL+ + + +D +PLH A + G +V LL+E+GA + T +G TPLH + ++ +L+ GA I + G +PLH+AT + + V LL+ + +D + N T LH ++L+ + AN + G TPL +A + + I ++++++K
Sbjct: 48 ALHLASKEGHVEVVTELIKLG-ATVDAATKKGNTALHIASLAGQADVVKELVNNGANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKAR---NDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVPVDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLK 392 HSP 6 Score: 80.8777 bits (198), Expect = 1.488e-15 Identity = 61/231 (26.41%), Postives = 108/231 (46.75%), Query Frame = 3
Query: 534 FKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
+++ D N + +L A + A I+ +D++ ++ NA HLA K GH + LI++ +D + LH A G +V+ L+ GAN++ + NGFTPL++ Q++ D++ L+ G+ + G TPL +A +V+LLL+N D LH ++ + +LL N K+G TPL +AA I++ +++
Sbjct: 5 IEVESTDSN--ASYLRAARAGNIEKALDYIKTGVDINICNQNGLNALHLASKEGHVEVVTELIKLGAT---VDAATKKGNTALHIASLAGQADVVKELVNNGANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLL 226
BLAST of Death domain protein vs. Ensembl Zebrafish
Match: ank3b (ankyrin 3b [Source:ZFIN;Acc:ZDB-GENE-060621-2]) HSP 1 Score: 149.058 bits (375), Expect = 6.120e-38 Identity = 100/328 (30.49%), Postives = 163/328 (49.70%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T LH+AA G+I +L+ G +VD + +TPL A+ G+ +V+ L+E+GA I R K G +H A ++E + R + + NG+SP +A + + + LI ++ V + A H+A GH +V K L+DK + + +PLH AC+ IK++ELL++ GA++ T +G TP+H+ +I+ L GA N N++G T LH+A + ++V L+ N AD+D +QTPLH K D V+ LL GA + +G TPL +AAR + + +++
Sbjct: 236 TPLHIAAHYGNINVATLLLNRG-AAVDFKARNDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLD--RGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVPVDDVTNDYLTALHVAAHCGH---------YKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSRLGKPDIVQQLLQHGALPDSTTTSGYTPLHLAARDGHKDVASILL 551 HSP 2 Score: 137.887 bits (346), Expect = 3.786e-34 Identity = 87/310 (28.06%), Postives = 159/310 (51.29%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
ALH+AA + +A +L+ + + DI K G TPL AA++G++ V L+ +GA + + + +H+A++ N++ + R ++D + +G++P + L+++ + K + H+A + H N LLI EVP +D + + + LH A G K+ ++L+++ AN + NGFTPLHI +K+ ++ LL+K GA I G TP+H+A ++VT L ++ A + +N R +T LH + + V+ L+ GA++ K +TPL +++R
Sbjct: 204 ALHIAARKDDTKAAALLL-QNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKARNDITPLHVASKRGNANMVRLLLE--RGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVP---VDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSR 507 HSP 3 Score: 125.946 bits (315), Expect = 3.817e-30 Identity = 93/320 (29.06%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
AA G+IE I G V ++I ++ G+ L A+ GH+EVV L++ GA + K+G +HIA+ ++++ + + ++ Q NG +P +A +N + K L++ S + +A + GH+ + +LL+E + ++ +L + LH A K LL++ N + +GFTPLHI ++ LL+ GA ++ + TPLH+A+ +MV LLL+ A +D TPLH G VE+LL RGA + + K G +PL MA +G +++ V ++I E
Sbjct: 47 AARAGNIEKALDYIKTG-VDINICNQNGLNALHLASKEGHVEVVTELIKLGATVDAATKKGNTALHIASLAGQADVVKELV--NNGANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV--RLPA-----LHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKARNDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHE 356 HSP 4 Score: 122.094 bits (305), Expect = 7.498e-29 Identity = 85/298 (28.52%), Postives = 140/298 (46.98%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLS 1148
D T LH+A+ +G+ R+L+ G +D K G+TPL A GH +VV+ L+++GA I + K G +H+A +G+ +N ++ + H +DD + ++ +A AK L++K + + H+ACK + LL++ + + S +P+H A G IV L GA+ + G T LH+ + A+++ L+ GAD++ + TPLHI++ P +V LL + A D TPLH D ILL GA+L
Sbjct: 267 DITPLHVASKRGNANMVRLLLERG-ARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLI--HHEVPVDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS---IQAVTESGLTPIHVAAFMGHENIVTQLTNHGASPNTMNVRGETALHMAARAGQANVVKFLVANGADVDAKAKDDQTPLHISSRLGKPDIVQQLLQHGALPDSTTTSGYTPLHLAARDGHKDVASILLDNGASLG 558 HSP 5 Score: 114.775 bits (286), Expect = 1.743e-26 Identity = 90/351 (25.64%), Postives = 166/351 (47.29%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVS-----------------------------KNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
ALH+A+ +GH+E LI G +VD K G T L A+ G +VV+ LV GA I+ +++ G +++AA+ N +++++++ + +D G +P +A+ K+ +A L++ D + K+ H+A G+ N+ LL+ + + +D +PLH A + G +V LL+E+GA + T +G TPLH + ++ +L+ GA I + G +PLH+AT + + V LL+ + +D + N T LH ++L+ + AN + G TPL +A + + I ++++++K
Sbjct: 76 ALHLASKEGHVEVVTELIKLG-ATVDAATKKGNTALHIASLAGQADVVKELVNNGANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFKAR---NDITPLHVASKRGNANMVRLLLERGARIDARTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLIHHEVPVDDVTNDYLTALHVAAHCGHYKVAKVLVDKRANPNAKALNGFTPLHIACKKNRIKVMELLLK 420 HSP 6 Score: 80.4925 bits (197), Expect = 1.922e-15 Identity = 59/220 (26.82%), Postives = 103/220 (46.82%), Query Frame = 3
Query: 567 SPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
+ +L A + A I+ +D++ ++ NA HLA K GH + LI++ +D + LH A G +V+ L+ GAN++ + NGFTPL++ Q++ D++ L+ G+ + G TPL +A +V+LLL+N D LH ++ + +LL N K+G TPL +AA I++ +++
Sbjct: 42 ASYLRAARAGNIEKALDYIKTGVDINICNQNGLNALHLASKEGHVEVVTELIKLGAT---VDAATKKGNTALHIASLAGQADVVKELVNNGANINAQSQNGFTPLYMAAQENHLDVVKFLLDNGSSQSIATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDHNADIESKSGFTPLHIAAHYGNINVATLLL 254
BLAST of Death domain protein vs. Ensembl Xenopus
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:NCBI gene;Acc:100489003]) HSP 1 Score: 297.36 bits (760), Expect = 3.120e-93 Identity = 189/529 (35.73%), Postives = 283/529 (53.50%), Query Frame = 3
Query: 144 LSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNG-FTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
L ++E H AA+ ND +R++I+ + DRTALH AA GH +A ++L+ E +D D +GM LL A+FGHL ++Q LV GA I+ +NK G +++H AA + ++E++ +LD D +G + F LA + + + LI S DK A HLA KNGH + ++E V EL +K ++ + LH A E G+ V +L++ G +++ T LH + DI +LI AG +IN N + +T LHI+ L N P+ V LL+D D+DI + R QTPLH E + D E++L+ G NL DK GKT L +AARG++I++ DMIIKA+RF ++ N D SD + ++ + D+ L+ + + +W++A L+ +EWKKLAHYW F HI AIE Q T S++ HG+R+L IW HG V + + P++GLYE LV IGRR LA+ IR + ++E
Sbjct: 12 LLRSERDFHNAAKTNDTEKMRQLIELGVDVRVKNSV-DRTALHWAAGAGHKQAVQLLL-EHDAPMDKEDSFGMNALLLGAWFGHLPILQILVNAGAKINCQNKNGLNLLHCAALRGHIKVMEFIMEDLEGIRLDKVDKSGKTAFHLAAEHGQLEAVEFLIGSGCQHSLKDKDKNTALHLATKNGHVEVLQKIVETGV--ELNEK-NTEGMTALHLATEGGYFDCVRILLDAGCDVNAQTEQKCMNGLHYSAFHGYEDIARILIDAGININAVNHRKSTALHISILQNFPATVKLLIDFECDLDIPDYRLQTPLHIAAENGRQDMAEMILIAGVNLKLQDKQGKTSLDVAARGNHINLADMIIKADRF-------------YKWEKDNLNSD--------SDSWVARHLTFRQ---------DHRLE------TQHIRSVIWRLATKYLKQNEWKKLAHYWRFTDAHIRAIEQQWTGTKSFRDHGHRMLLIWLHGVVMAGENPIKGLYEGLVGIGRRDLAESIRSKANAE 499
BLAST of Death domain protein vs. Ensembl Xenopus
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:NCBI gene;Acc:100489003]) HSP 1 Score: 277.715 bits (709), Expect = 7.393e-86 Identity = 178/529 (33.65%), Postives = 270/529 (51.04%), Query Frame = 3
Query: 141 ELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
E+ ++E H AA+ ND +R++I+ + DRTALH AA GH +A ++L+ E +D D +GM LL A+FGHL ++Q LV GA I+ +NK G +++H AA + ++E++ +LD D +G + F LA + + + LI S DK A HLA KNGH + ++E V EL +K ++ + LH A E G+ V +L++ G +++ T LH + DI +LI AG +IN + +T LHI+ L N P+ V LL+D D+DI + R QTPLH E + D E++L+ G NL DK GKT L +AARG++I++ D ++ A D Y ++ ++ + + +W++A L+ +EWKKLAHYW F HI AIE Q T S++ HG+R+L IW HG V + + P++GLYE LV IGRR LA+ IR + ++E
Sbjct: 24 EVLRSERDFHNAAKTNDTEKMRQLIELGVDVRVKNSV-DRTALHWAAGAGHKQAVQLLL-EHDAPMDKEDSFGMNALLLGAWFGHLPILQILVNAGAKINCQNKNGLNLLHCAALRGHIKVMEFIMEDLEGIRLDKVDKSGKTAFHLAAEHGQLEAVEFLIGSGCQHSLKDKDKNTALHLATKNGHVEVLQKIVETGV--ELNEK-NTEGMTALHLATEGGYFDCVRILLDAGCDVNAQTEKCMNGLHYSAFHGYEDIARILIDAGININ----RKSTALHISILQNFPATVKLLIDFECDLDIPDYRLQTPLHIAAENGRQDMAEMILIAGVNLKLQDKQGKTSLDVAARGNHINLA--------------------------------DMIIKA-----------------------DRFYKWEKDHRLETQHIRSVIWRLATKYLKQNEWKKLAHYWRFTDAHIRAIEQQWTGTKSFRDHGHRMLLIWLHGVVMAGENPIKGLYEGLVGIGRRDLAESIRSKANAE 488
BLAST of Death domain protein vs. Ensembl Xenopus
Match: ptprc (protein tyrosine phosphatase, receptor type C [Source:Xenbase;Acc:XB-GENE-981257]) HSP 1 Score: 265.774 bits (678), Expect = 1.321e-80 Identity = 176/538 (32.71%), Postives = 277/538 (51.49%), Query Frame = 3
Query: 156 ELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLY---LWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGV-ESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCI 1757
E+ H+AA++ D++L + + AN+N KNNL+RTALH A + ++A L+ K VDI DK+G+T L AA+ L +VQ L++ G N+ G +++H AA+ + +I+EY+ + + L+ D PF LA K + LIE ++ + DK A H A KNGH ++ L+E+ E+ D+ + S +P + A G + ELL+ +G+N++ T +G+ LHI Q F + L+ + N + + N P H+A L+N ++ +LL+ D++ N R+Q+PLH E + VE LL+ G +L+ DK KT L AAR ++I +VDMIIKAER+ + N+N GD + F Q +A + +L LW +A+ +L+ DEWKK+A W F I AIE Q T SYK H +R+L IW HGV +++ P++ LYE LV +G ++ A+ R E + G ++ CI
Sbjct: 66 EMAFHDAAKK-DDVLAMTRLLEQKANINAKNNLNRTALHFAVAANKMQAVSFLLSH-KARVDIADKHGLTVLHLAAWSADLTIVQMLIKAGISQKATNQDGMNVLHFAAQNDKNDIVEYLIKDLQLKDLNILDKKKRKPFHLAAEKGHIDMVTKLIEFELFTLEKDKEGNTALHYAAKNGHSSVVETLLEIWKENEI-DEPNESGATPFYLAAGGGHVACAELLLHKGSNINTTTHDGYGALHIAAQNGFTSFVSFLLNNAIESNPEPNERNNPFHLALLNNHMEIIDILLERKYDINATNARQQSPLHLAAEYKNTELVEKLLIAGCDLTISDKQKKTALGTAARSNHILIVDMIIKAERY---------YGLIQGPNENSEQGD------------------------------QEEILTFKQDHASKTRLIRSALWNLAYKHLKPDEWKKMAQGWKFTEAQIKAIEEQWTGKESYKEHCHRMLLIWLHGVLLAKENPIKALYEVLVEMGHKETAENFRAEC-TNGSNTEAKKCCI 560
BLAST of Death domain protein vs. Ensembl Xenopus
Match: ptprc (protein tyrosine phosphatase, receptor type C [Source:Xenbase;Acc:XB-GENE-981257]) HSP 1 Score: 238.81 bits (608), Expect = 1.088e-70 Identity = 171/540 (31.67%), Postives = 267/540 (49.44%), Query Frame = 3
Query: 156 ELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIE--QGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLY---LWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGV-ESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCI 1757
E+ H+AA++ D++L + + AN+N KNNL+RTALH A + ++A L+ K VDI DK+G+T L AA+ L +VQ L++ G N+ G +++H AA+ + +I+EY+ K L KD+++ LDK + +HLA + GH ++ LIE E+ + D + LHYA +NG +VE L+E + + +P +G TP ++ LL+ G++IN + N P H+A L+N ++ +LL+ D++ N R+Q+PLH E + VE LL+ G +L+ DK KT L AAR ++I +VDMIIKAER+ + N+N GD + F Q +A + +L LW +A+ +L+ DEWKK+A W F I AIE Q T SYK H +R+L IW HGV +++ P++ LYE LV +G ++ A+ R E + G ++ CI
Sbjct: 66 EMAFHDAAKK-DDVLAMTRLLEQKANINAKNNLNRTALHFAVAANKMQAVSFLLSH-KARVDIADKHGLTVLHLAAWSADLTIVQMLIKAGISQKATNQDGMNVLHFAAQNDKNDIVEYLI-------------------------------KDLQLKDLNI--LDKKKRKPFHLAAEKGHIDMVTKLIEFEL---FTLEKDKEGNTALHYAAKNGHSSVVETLLEIWKENEIDEPNESGATPFYLAAGGGHVACAELLLHKGSNINTTTHERNNPFHLALLNNHMEIIDILLERKYDINATNARQQSPLHLAAEYKNTELVEKLLIAGCDLTISDKQKKTALGTAARSNHILIVDMIIKAERY---------YGLIQGPNENSEQGD------------------------------QEEILTFKQDHASKTRLIRSALWNLAYKHLKPDEWKKMAQGWKFTEAQIKAIEEQWTGKESYKEHCHRMLLIWLHGVLLAKENPIKALYEVLVEMGHKETAENFRAEC-TNGSNTEAKKCCI 527
BLAST of Death domain protein vs. Ensembl Xenopus
Match: ANKDD1A (ankyrin repeat and death domain containing 1A [Source:NCBI gene;Acc:100489003]) HSP 1 Score: 233.032 bits (593), Expect = 5.226e-69 Identity = 159/530 (30.00%), Postives = 257/530 (48.49%), Query Frame = 3
Query: 144 LSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGN-TPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVN-AFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
L ++E H AA+ ND +R++I+ + DRTALH AA GH +A ++L+ E +D D +GM LL A+FGHL ++Q LV GA I+ +NK G +++H AA + ++E++ +D G I + ++DK+ K A+HLA ++G LI L DK + LH A +NG +++++ ++E G L++ G T LH+ T+ + D + +L+ AG D+N Q Q LH + + +L+D +++ +N+R+ T LH + QN +V++L+ +L D +TPL +AA M +MI+ A VN Q D N S + + ++ ++ + + +W++A L+ +EWKKLAHYW F HI AIE Q T S++ HG+R+L IW HG V + + P++GLYE LV IGRR LA+ IR + ++E
Sbjct: 12 LLRSERDFHNAAKTNDTEKMRQLIELGVDVRVKNSV-DRTALHWAAGAGHKQAVQLLL-EHDAPMDKEDSFGMNALLLGAWFGHLPILQILVNAGAKINCQNKNGLNLLHCAALRGHIKVMEFIM----------EDLEG-----------------------IRLDKVDKSGKTAFHLAAEHGQLEAVEFLIGSGCQHSLKDK---DKNTALHLATKNGHVEVLQKIVETGVELNEKNTEGMTALHLATEGGYFDCVRILLDAGCDVNAQTEQKCMNGLHYSAFHGYEDIARILIDAGININAVNHRKSTALHISILQNFPATVKLLIDFECDLDIPDYRLQTPLHIAAENGRQDMAEMILIAG----------------------------VNLKLQDKDNLN--------SDSDSWVARHLTFRQDHRLETQHIRSVIWRLATKYLKQNEWKKLAHYWRFTDAHIRAIEQQWTGTKSFRDHGHRMLLIWLHGVVMAGENPIKGLYEGLVGIGRRDLAESIRSKANAE 467
BLAST of Death domain protein vs. Ensembl Mouse
Match: Ankdd1a (ankyrin repeat and death domain containing 1A [Source:MGI Symbol;Acc:MGI:2686319]) HSP 1 Score: 283.108 bits (723), Expect = 7.552e-88 Identity = 167/490 (34.08%), Postives = 251/490 (51.22%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
R ALH AA GH +A R+L+ G +VD D +GM LL +A+FGHL++VQ LV GA + +K G ++H AA+ V +L ++ LD D G + F A + + L+ D S DK A HLA GH ++ L+++ + +++ ++ + LH A E V LL+ G+N++ T + LH D+ LIKAG N + QG TP+H+A N P +V LL+D ++D+D ++ R QTPLH E D ++LL+ GA+LS DK GKT L +AAR +++S+VDMIIKA+RF + HL + + + K+ ++ ++ + LW++A LR +EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA+ R + E
Sbjct: 49 RVALHWAAGAGHEQAVRLLLERG-AAVDDVDSFGMNSLLLSAWFGHLQIVQILVNAGAKVHCESKDGLTLLHCAAQKGHVPVLAFVMEDLEDVALDHADKLGRTAFHRAAEHGQLDALDFLVGSGCDHSVKDKGGNTALHLAASQGHVDVLQRLVDIGLD---LEEQNTEGLTALHAAAEGIHADCVMLLLGAGSNVNALTQKRLSCLHYAALGGSEDLSRALIKAGGCTNVADKQGTTPMHLAVKHNFPGLVQLLIDGHSDLDAVDIRRQTPLHLAAEHAWQDVADMLLIAGADLSLRDKQGKTALAVAARSNHVSLVDMIIKADRF-----------------------------------YRWEKDHLSCRDGSDVSRKNLTFKQDHRQETQQLRSVLWRLASRYLRPNEWKKLAYSWQFTEAHVCAIEQQWTGTRSYQEHGHRMLLIWLHGVAAAGENPSKALFEGLVAIGRRDLAESTRNMANGE 499
BLAST of Death domain protein vs. Ensembl Mouse
Match: Ankdd1a (ankyrin repeat and death domain containing 1A [Source:MGI Symbol;Acc:MGI:2686319]) HSP 1 Score: 276.559 bits (706), Expect = 1.050e-85 Identity = 168/490 (34.29%), Postives = 246/490 (50.20%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
R ALH AA GH +A R+L+ G +VD D +GM LL +A+FGHL++VQ LV GA + +K G ++H AA+ V +L ++ LD D G + F A + + L+ D S DK A HLA GH ++ L+++ + +++ ++ + LH A E V LL+ G+N++ T + LH D+ LIKAG N + QG TP+H+A N P +V LL+D ++D+D ++ R QTPLH E D ++LL+ GA+LS DK GKT L +AAR +++S+VDMIIKA+RF Y H +E++Q + LW++A LR +EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA+ R + E
Sbjct: 39 RVALHWAAGAGHEQAVRLLLERG-AAVDDVDSFGMNSLLLSAWFGHLQIVQILVNAGAKVHCESKDGLTLLHCAAQKGHVPVLAFVMEDLEDVALDHADKLGRTAFHRAAEHGQLDALDFLVGSGCDHSVKDKGGNTALHLAASQGHVDVLQRLVDIGLD---LEEQNTEGLTALHAAAEGIHADCVMLLLGAGSNVNALTQKRLSCLHYAALGGSEDLSRALIKAGGCTNVADKQGTTPMHLAVKHNFPGLVQLLIDGHSDLDAVDIRRQTPLHLAAEHAWQDVADMLLIAGADLSLRDKQGKTALAVAARSNHVSLVDMIIKADRF----------------------------------YRWEKQDHRQETQQ--------------------LRSVLWRLASRYLRPNEWKKLAYSWQFTEAHVCAIEQQWTGTRSYQEHGHRMLLIWLHGVAAAGENPSKALFEGLVAIGRRDLAESTRNMANGE 470
BLAST of Death domain protein vs. Ensembl Mouse
Match: Ankdd1b (ankyrin repeat and death domain containing 1B [Source:MGI Symbol;Acc:MGI:2444730]) HSP 1 Score: 233.032 bits (593), Expect = 2.182e-68 Identity = 146/489 (29.86%), Postives = 241/489 (49.28%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYA---EEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRR 1709
+RTALH A + + A L+ K VD+ DK+G+T + AA+ G E++ LV+ GA +N++G + +H+AA+ N ++I++Y+ L+ + G PF LA + V + LI ++ S+ DK A HLA +GH +L+ +++ + + ++P A G + +L+ G++++ P + L T+ ++ L+ AD+ Q PLH+A ++N P++V LL D+D+++ R QTPLH + + VE LL G NL DK GKT L +AAR + +VDM+IKAER Y EE ++++ D S F Q ++ + + LW +A+ L+ +W++LA W F + I AIE Q + ++S+ HGYR L IW HG + +Q P + LYE L+ G +LA+KIR+
Sbjct: 94 NRTALHFAVGRNSLSAVDFLLSH-KARVDVADKHGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNNNLHIVDYLIHDLHLHDLNQPNERGRKPFHLAAERGHVEMIEKLIFLNLHTSEKDKDGNTALHLAAMHGHSPAVQVLLTQWSE---VNESNENGETPFLLAVVGGHEECSRVLLAGGSDVNIPNKLNVSALQTATRNGHTALVNFLLGENADLQQQKESKEPPLHLAVINNRPAVVNSLLSARHDVDVLDQRRQTPLHVAADLGNVELVETLLKAGCNLKITDKQGKTALAVAARSQHSLVVDMLIKAER---------------------------------------YYAWREEHRESIQDSAVSSTLTFKQDHSLETRQIRTLLWNLAYRQLKKKDWQRLARLWSFTEDQIRAIEEQWSGNDSFHEHGYRALLIWLHGALLTQLDPAKQLYEELLCAGFPELAEKIRQ 539 HSP 2 Score: 70.8626 bits (172), Expect = 2.283e-12 Identity = 47/184 (25.54%), Postives = 92/184 (50.00%), Query Frame = 3
Query: 681 ACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDN--NADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
A K+ + ++ L E +V ++ +++ +++ LH+A + V+ L+ A + +G T +H+ +I+L+L+KAGAD +N +G LH+A +N +V L+ + D++ N R + P H E+ + +E L+ + S DK G T L +AA + V +++
Sbjct: 68 AAKSSNLDLMEKLFEKKVN---INAVNNMNRTALHFAVGRNSLSAVDFLLSHKARVDVADKHGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNNNLHIVDYLIHDLHLHDLNQPNERGRKPFHLAAERGHVEMIEKLIFLNLHTSEKDKDGNTALHLAAMHGHSPAVQVLL 248
BLAST of Death domain protein vs. Ensembl Mouse
Match: Ankdd1b (ankyrin repeat and death domain containing 1B [Source:MGI Symbol;Acc:MGI:2444730]) HSP 1 Score: 214.542 bits (545), Expect = 7.634e-62 Identity = 141/489 (28.83%), Postives = 227/489 (46.42%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYA---EEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRR 1709
+RTALH A + + A L+ K VD+ DK+G+T + AA+ G E++ LV+ GA +N++G + +H+AA+ N ++I++Y+ L+ + G PF HLA + GH + LI + + DK + LH A +G V++L+ Q + +++ + L T+ ++ L+ AD+ Q PLH+A ++N P++V LL D+D+++ R QTPLH + + VE LL G NL DK GKT L +AAR + +VDM+IKAER Y EE ++++ D S F Q ++ + + LW +A+ L+ +W++LA W F + I AIE Q + ++S+ HGYR L IW HG + +Q P + LYE L+ G +LA+KIR+
Sbjct: 94 NRTALHFAVGRNSLSAVDFLLSH-KARVDVADKHGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNNNLHIVDYLIHDLHLHDLNQPNERGRKPF---------------------------------HLAAERGHVEMIEKLIFLNLHTSEKDK---DGNTALHLAAMHGHSPAVQVLLTQWSEVNESNELNVSALQTATRNGHTALVNFLLGENADLQQQKESKEPPLHLAVINNRPAVVNSLLSARHDVDVLDQRRQTPLHVAADLGNVELVETLLKAGCNLKITDKQGKTALAVAARSQHSLVVDMLIKAER---------------------------------------YYAWREEHRESIQDSAVSSTLTFKQDHSLETRQIRTLLWNLAYRQLKKKDWQRLARLWSFTEDQIRAIEEQWSGNDSFHEHGYRALLIWLHGALLTQLDPAKQLYEELLCAGFPELAEKIRQ 506
BLAST of Death domain protein vs. Ensembl Mouse
Match: Ank2 (ankyrin 2, brain [Source:MGI Symbol;Acc:MGI:88025]) HSP 1 Score: 147.902 bits (372), Expect = 1.139e-36 Identity = 96/324 (29.63%), Postives = 164/324 (50.62%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
T LH+AA G++ +L+ G +VD + G+TPL A+ G+ +V+ L+++G I + + G +H AA ++E + R L + NG+SP +A + V K L++ V + A H+A GH + LL++ + + +PLH AC+ IK++ELL++ GA++ T +G TP+H+ +I+LLL++ GA + N++G T LH+A + +V LL N A +D EQTPLH K + V++LL A+ G TPL ++AR + + ++++A
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531 HSP 2 Score: 146.747 bits (369), Expect = 3.228e-36 Identity = 99/323 (30.65%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+AA GH+ +L+ + S D+ + G T L AA G +EVV+ L+ GA++ R ++ +HIA+ I++ + + H D NG +P ++ + V A L+E S K H+A K G ++ LL++ + D + +PLH A K+ LL+E+GA+ NG+TPLHI +K+ I L+ GA+ N QG TPLH+A+ MVTLLLD A++ + T LH +++K + +IL GA+ K G TPL++A + MV+ ++K
Sbjct: 412 TPIHVAAFMGHLNIV-LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP--DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR---RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLK 728 HSP 3 Score: 130.568 bits (327), Expect = 4.857e-31 Identity = 101/358 (28.21%), Postives = 163/358 (45.53%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A ++T LH+A+ G E ++L+ + D G TPL +A G ++V L+E GA S K+G +H+AA+ +++ + + + R D NG++P +A + A L+EK K H+A K I + L+ + K +PLH A + G +V LL+++GAN+ T +G T LH+ Q+ ++ +L K GAD + G TPL +A MV LL A+++ TPLH +Q + +LL GA + G T L +A R YIS+VD +
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792 HSP 4 Score: 123.635 bits (309), Expect = 8.486e-29 Identity = 89/323 (27.55%), Postives = 147/323 (45.51%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALHMAA G +E R L+ G + VD + TPL A+ G E+VQ L++ A G +HI+A V++ + L + G +P +A + AK L+++ K H+A ++ + LL+E K + +PLH A + ++I L+ GA + T G TPLH+ +Q+ D++ LL+ GA+I+ G T LH+A + ++ +L + AD D TPL V LL +GAN++ K G TPL AA+ + +++++++
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761 HSP 5 Score: 122.479 bits (306), Expect = 2.046e-28 Identity = 89/326 (27.30%), Postives = 162/326 (49.69%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE----MEVPKELM-DKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
ALH+AA +GH+ + L+ G SVD K G T L A+ G EVV+ LV++GA I+ +++ G +++AA+ N +++++Y+ + +D G +P +A+ + + L+E D K A H+A + LL++ +V ++M ++ S +PLH A G + + LL+ +GA + NG TPLH+ +++ +++ LL+ G I+ + G TPLH A S +V LLL+ A + +PLH + + + V+ LL A + ++ T L +AA + + +++
Sbjct: 46 ALHLAAKEGHVGLVQELLGRGS-SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATED--GFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 364 HSP 6 Score: 118.242 bits (295), Expect = 3.992e-27 Identity = 84/312 (26.92%), Postives = 147/312 (47.12%), Query Frame = 3
Query: 318 FEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGAN--------LSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+G + ++ ++ G+ L AA GH+ +VQ L+ +G+ + K+G +HIA+ +++ + ++ ++ Q NG +P +A +N + K L+E + S + +A + GH +L+E + ++ +L + LH A K LL++ N +++ T +GFTPLHI ++ LL+ GA ++ G TPLH+A+ +MV LLLD +D TPLH VE+LL R A L K G +PL MAA+G ++ V +++
Sbjct: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332 HSP 7 Score: 111.309 bits (277), Expect = 8.333e-25 Identity = 93/360 (25.83%), Postives = 167/360 (46.39%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK-----------HRHFKLDD---------QDYN---------------GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEM--EVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+A+ G E ++L+ EG +++ + G TPL AA H++VV++L+E GA S + G + +A + + + H + DD D+N G +P +A V A L+ + V + H+A K G+ N+ LL++ ++ + D L +PLH A +G ++VELL+E+ A L T NG +PLH+ Q + + L++ A ++ + T LH+A + LLLD A+ + TPLH ++N+ +E+L+ GA++ I ++G TP+ +AA ++++V ++++
Sbjct: 78 TALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-----TPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
BLAST of Death domain protein vs. UniProt/SwissProt
Match: sp|Q9GKW8|AND1A_MACFA (Ankyrin repeat and death domain-containing protein 1A (Fragment) OS=Macaca fascicularis OX=9541 GN=ANKDD1A PE=2 SV=3) HSP 1 Score: 266.929 bits (681), Expect = 2.743e-81 Identity = 161/484 (33.26%), Postives = 250/484 (51.65%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEE---FKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLAD 1697
R ALH AA GH +A R+L+ E + +VD D +GM LL +A+FGHL ++Q LV GA I ++K G ++H AA+ V +L ++ LD D G + F A + + L+ D S DK A HLA GH + L+++ + +++ ++ + LH A V LL+ G+ ++ T + LH D+ +LI AG N + G +PLH+A + N P++V LL+++++D++ ++NR+QTPLH E D E+LL+ G +L+ DK GKT L +AAR +++S+VDMIIKA+RF + D+ + ++ DP F Q + +E + LW++A +L+ EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA+
Sbjct: 21 RVALHWAAGAGHEQAVRLLL-EHEAAVDEEDAFGMNALLLSAWFGHLRILQILVNSGAKIHCKSKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHSVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAEGLTALHAAAGGTHPHCVRLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCTNVAD-HGASPLHLAVMHNFPALVQLLINSDSDLNAMDNRQQTPLHLAAEHAWQDIAEMLLIAGVDLNLRDKQGKTALAVAARSNHVSLVDMIIKADRFYK----------------------------WEKDHLSCRDL----------SDPSGKSLSFKQDHRQETQQLRSVLWRLASRHLQPREWKKLAYSWDFTEAHVYAIEQQWTGTRSYQEHGHRMLLIWLHGVSTAGENPSKALFEGLVTIGRRDLAE 461
BLAST of Death domain protein vs. UniProt/SwissProt
Match: sp|Q495B1|AKD1A_HUMAN (Ankyrin repeat and death domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKDD1A PE=2 SV=2) HSP 1 Score: 258.07 bits (658), Expect = 2.276e-77 Identity = 169/529 (31.95%), Postives = 264/529 (49.91%), Query Frame = 3
Query: 156 ELCLHEAARQND-----EMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDK----------YGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQ-DTPVRGLYEALVSIGRRKLA 1694
E LHEAARQN+ E++ R++ + ++ R ALH AA GH +A R+L+ E + +VD D +GM LL +A+FGHL ++Q LV GA I +K G ++H AA+ V +L ++ LD D G + F A + + L+ D + DK A HLA GH + L+++ + +++ ++ + LH A V+LL+ G+ ++ T + LH D+ +LI AG N + QG +PLH+A N P++V LL+++++D++ ++NR+QTPLH E D ++LL+ G +L+ DK GKT L +A R +++S+VDMIIKA+RF + PSD S K+ ++ ++ + LW++A L+ EWKKLA+ W F H+ AIE Q T SY+ HG+R+L IW HGV + + P + L+E LV+IGRR LA
Sbjct: 16 ERQLHEAARQNNVGRMQELIGRRVNTRARNHV------GRVALHWAAGAGHEQAVRLLL-EHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRF------------------------YRWEKDHPSDP----------------SGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKALFEGLVAIGRRDLA 494
BLAST of Death domain protein vs. UniProt/SwissProt
Match: sp|A6NHY2|AKD1B_HUMAN (Ankyrin repeat and death domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ANKDD1B PE=4 SV=3) HSP 1 Score: 215.312 bits (547), Expect = 3.602e-61 Identity = 143/487 (29.36%), Postives = 228/487 (46.82%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEE---FKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIR 1706
RTALH A + H+ A L+ + K VD+ DK+G+T + AA+ G LEV+ LV+ GA +N+ G +H A + N V I+EY+ + L+ D G PFLLA + V + L ++ S+ DK A LH A ++G V++L+ Q ++++ + L I T+ A ++ L+ D++ + +PLH+ ++N ++V LL D+DI+N ++QTPLH ++ + VE LL G +L +DK GKT L +A+R ++ +V M+IKAER Y EE +++ D F Q ++ E + LW +A++ L+ +EW++LA W F + I AIE Q + + S++ HG+R L IW HG + +Q P + LYE LV G KLA+K R
Sbjct: 102 RTALHFAVGRNHLSAVDFLL-KHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKGGNTA------------------------------------LHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAER---------------------------------------YYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTLMTQGDPAKQLYEELVHAGFPKLAEKTR 512
BLAST of Death domain protein vs. UniProt/SwissProt
Match: sp|Q14DN9|AKD1B_MOUSE (Ankyrin repeat and death domain-containing protein 1B OS=Mus musculus OX=10090 GN=Ankdd1b PE=2 SV=3) HSP 1 Score: 214.542 bits (545), Expect = 5.340e-61 Identity = 141/489 (28.83%), Postives = 227/489 (46.42%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYA---EEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHG-VESQDTPVRGLYEALVSIGRRKLADKIRR 1709
+RTALH A + + A L+ K VD+ DK+G+T + AA+ G E++ LV+ GA +N++G + +H+AA+ N ++I++Y+ L+ + G PF HLA + GH + LI + + DK + LH A +G V++L+ Q + +++ + L T+ ++ L+ AD+ Q PLH+A ++N P++V LL D+D+++ R QTPLH + + VE LL G NL DK GKT L +AAR + +VDM+IKAER Y EE ++++ D S F Q ++ + + LW +A+ L+ +W++LA W F + I AIE Q + ++S+ HGYR L IW HG + +Q P + LYE L+ G +LA+KIR+
Sbjct: 94 NRTALHFAVGRNSLSAVDFLLSH-KARVDVADKHGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNNNLHIVDYLIHDLHLHDLNQPNERGRKPF---------------------------------HLAAERGHVEMIEKLIFLNLHTSEKDK---DGNTALHLAAMHGHSPAVQVLLTQWSEVNESNELNVSALQTATRNGHTALVNFLLGENADLQQQKESKEPPLHLAVINNRPAVVNSLLSARHDVDVLDQRRQTPLHVAADLGNVELVETLLKAGCNLKITDKQGKTALAVAARSQHSLVVDMLIKAER---------------------------------------YYAWREEHRESIQDSAVSSTLTFKQDHSLETRQIRTLLWNLAYRQLKKKDWQRLARLWSFTEDQIRAIEEQWSGNDSFHEHGYRALLIWLHGALLTQLDPAKQLYEELLCAGFPELAEKIRQ 506
BLAST of Death domain protein vs. UniProt/SwissProt
Match: sp|Q8C8R3|ANK2_MOUSE (Ankyrin-2 OS=Mus musculus OX=10090 GN=Ank2 PE=1 SV=2) HSP 1 Score: 147.517 bits (371), Expect = 1.859e-35 Identity = 99/330 (30.00%), Postives = 165/330 (50.00%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
T LH+AA G++ +L+ G +VD + G+TPL A+ G+ +V+ L+++G I + + G +H AA ++E + R L + NG+SP +A + V K L++ V + A H+A GH V K L+DK + + +PLH AC+ IK++ELL++ GA++ T +G TP+H+ +I+LLL++ GA + N++G T LH+A + +V LL N A +D EQTPLH K + V++LL A+ G TPL ++AR + + ++++A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGH---------YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552 HSP 2 Score: 146.747 bits (369), Expect = 3.436e-35 Identity = 99/323 (30.65%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+AA GH+ +L+ + S D+ + G T L AA G +EVV+ L+ GA++ R ++ +HIA+ I++ + + H D NG +P ++ + V A L+E S K H+A K G ++ LL++ + D + +PLH A K+ LL+E+GA+ NG+TPLHI +K+ I L+ GA+ N QG TPLH+A+ MVTLLLD A++ + T LH +++K + +IL GA+ K G TPL++A + MV+ ++K
Sbjct: 433 TPIHVAAFMGHLNIV-LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH--PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR---RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLK 749 HSP 3 Score: 130.568 bits (327), Expect = 4.735e-30 Identity = 101/358 (28.21%), Postives = 163/358 (45.53%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A ++T LH+A+ G E ++L+ + D G TPL +A G ++V L+E GA S K+G +H+AA+ +++ + + + R D NG++P +A + A L+EK K H+A K I + L+ + K +PLH A + G +V LL+++GAN+ T +G T LH+ Q+ ++ +L K GAD + G TPL +A MV LL A+++ TPLH +Q + +LL GA + G T L +A R YIS+VD +
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813 HSP 4 Score: 124.405 bits (311), Expect = 5.099e-28 Identity = 89/323 (27.55%), Postives = 147/323 (45.51%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALHMAA G +E R L+ G + VD + TPL A+ G E+VQ L++ A G +HI+A V++ + L + G +P +A + AK L+++ K H+A ++ + LL+E K + +PLH A + ++I L+ GA + T G TPLH+ +Q+ D++ LL+ GA+I+ G T LH+A + ++ +L + AD D TPL V LL +GAN++ K G TPL AA+ + +++++++
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782 HSP 5 Score: 123.635 bits (309), Expect = 9.075e-28 Identity = 88/326 (26.99%), Postives = 161/326 (49.39%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEME-----VPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
ALH+AA +GH+ + L+ G SVD K G T L A+ G EVV+ LV++GA I+ +++ G +++AA+ N +++++Y+ + +D G +P +A+ + + L+E D K A H+A + LL++ + K ++++ S +PLH A G + + LL+ +GA + NG TPLH+ +++ +++ LL+ G I+ + G TPLH A S +V LLL+ A + +PLH + + + V+ LL A + ++ T L +AA + + +++
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGS-SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATED--GFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385 HSP 6 Score: 119.013 bits (297), Expect = 2.736e-26 Identity = 87/326 (26.69%), Postives = 155/326 (47.55%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGAN--------LSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
AA G+++ + +G + ++ ++ G+ L AA GH+ +VQ L+ +G+ + K+G +HIA+ +++ + ++ + ++ Q NG +P +A +N + K L+E + S + +A + GH +L+E + ++ +L + LH A K LL++ N +++ T +GFTPLHI ++ LL+ GA ++ G TPLH+A+ +MV LLLD +D TPLH VE+LL R A L K G +PL MAA+G ++ V +++
Sbjct: 38 AARAGNLDKV-VEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN--INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353 HSP 7 Score: 114.39 bits (285), Expect = 7.922e-25 Identity = 93/360 (25.83%), Postives = 167/360 (46.39%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRK-----------HRHFKLDD---------QDYN---------------GMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEM--EVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+A+ G E ++L+ EG +++ + G TPL AA H++VV++L+E GA S + G + +A + + + H + DD D+N G +P +A V A L+ + V + H+A K G+ N+ LL++ ++ + D L +PLH A +G ++VELL+E+ A L T NG +PLH+ Q + + L++ A ++ + T LH+A + LLLD A+ + TPLH ++N+ +E+L+ GA++ I ++G TP+ +AA ++++V ++++
Sbjct: 99 TALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-----TPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
BLAST of Death domain protein vs. TrEMBL
Match: A0A267GYL2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005699g2 PE=4 SV=1) HSP 1 Score: 440.654 bits (1132), Expect = 1.371e-144 Identity = 249/561 (44.39%), Postives = 349/561 (62.21%), Query Frame = 3
Query: 78 LDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIE-KDIDVSQLDKTNKNAWHLACKNGHENIFN-LLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXX-XANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVF----DD-------PDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELD 1718
+ + P + +DDCDM T+L+ +SK EL LHEAAR E R ++C+NNL+RTALHMAAS+G A R+L+ E K +++ DKYGMT L+WA YFGH+EVV+ L+E+ A + KRNK G +HIAA+ N ++ K + L+D + NG + ++A K + + L+ ++D+ D A HLA +NG + LL E+ ++L+++ D S++ PLHYA E G I + L+ G+ ++ T H+ K D++ L + GA++N N+ +T LH A L++ + L+ + + NNR QTPLH VEQNK ++ E LLL A ++ DKTGKTPL++A RGSYISMVDMIIKAER+ +RKK Q E + A ++ + D V ++P+DY N NI+ ++ DD P Y L+EF QPYAEEFK YLWK+AF +LR +EWKKLA +W FK EH+ AIE+Q T ++SYK HGYRVLCIWFHGV+ QDTP+R LYEAL SIGRR LA+K+RR+LD
Sbjct: 1 MAADPLKPEDDCDMATTLEEPFMSKGELALHEAARTGKEA--RLEELLTIVKVDCRNNLNRTALHMAASKGQTGAVRVLL-EYKAGIELADKYGMTALMWATYFGHIEVVELLLERSASVKKRNKLGMHALHIAADQNNCELVRLYLTKTKKSILNDTEKNGQTALMIAAGKGNIEVVQLLLSYPEVDLMVKDAKKMTALHLAAENGCAKVLEELLREVYKLRDLVNEKDESERIPLHYAVEKGHIGAIRCLLTHGSEVNATAEREMTAFHLAAVKGHMDVLKYLKEHGANVNALNLTHSTALHYAALNDSAEQIFTLVSLGCETSLPNNRNQTPLHLAVEQNKPNAAEALLLCDAPINVRDKTGKTPLILATRGSYISMVDMIIKAERYRERKKRQQSGEAKHPTALVDQLDSDGAV--YKPADYENRININEPTEEELEQEISADDAMHNGTVPTYRLREFQQPYAEEFKQYLWKLAFKHLRQNEWKKLAAFWQFKTEHVEAIEHQYTDESSYKQHGYRVLCIWFHGVDRQDTPIRELYEALASIGRRPLAEKVRRQLD 556
BLAST of Death domain protein vs. TrEMBL
Match: A0A1I8I1A7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 436.802 bits (1122), Expect = 1.141e-142 Identity = 248/582 (42.61%), Postives = 351/582 (60.31%), Query Frame = 3
Query: 84 SGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIF-NLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQ-----------KSFAD----------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEE------SKQAVFDD---PDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELD 1718
S PKR +DDCDMVTSLQ LSK EL LHEAAR + + K+IK + DRTALHMAAS+GH E RILI GK SV++ DK+GM+PL+WA YFGH+EVV L+++ A I +RNK G +VHIAAE N +++ K + L+D + NGM+ ++A +K ++LI D+ D + H+A ++G+E + NL+ + +EL+++ D + P+HYA E GF VE+L+ GA+ + T +P + + ++FAD I+ L++AG DI+ N G T LH A L++ + V L+ D+ NNR QTPLH EQN+ + E LLL GA L+ DKTGKTPL++A +G I +VDMIIKAER ++ + + + E + + + + AF P Y N NI+ E ++ + ++ P Y L+EFNQPYA+EFKL+LWK+AF++LR+ EWKKLA +W F+ +HI AIE Q + + SYK HGYRVLCIWFHG+ DTP+RGLYEALV I RR LA+++R++LD
Sbjct: 5 SMPKRSEDDCDMVTSLQEPFLSKAELALHEAARSGNRTRVEKLIKVTGKIDCRNSL-DRTALHMAASKGHREIVRILIESGKASVEVTDKFGMSPLMWATYFGHIEVVNLLLDRSANIRRRNKLGMHVVHIAAEQNHCELVKIFINKTKKTLLNDTEKNGMTAVMIAAAKGNGEVVQSLISLGADLKIRDNRKRTVLHVAAESGNERVLDNLIADGPKMRELINERDDRGRMPIHYAVEKGFAGAVEILLAFGASPNDTTDPEMSPFLLAAREKKPNEDEQPAEAFADGAAPGEGGKPRPQHGEILRRLVQAGTDIDAVNSNGYTALHYAALNDDANAVYTLVHFGCDISAKNNRMQTPLHMAAEQNRLRAAEALLLSGAPLNIADKTGKTPLVLATQGGCICIVDMIIKAERHREKVQRVLKNEPNQWDSAAQADQLDAAAAFTPDGYENRSNINESENIDDELTESFILENGTAPAYRLREFNQPYADEFKLFLWKLAFDHLRYGEWKKLALFWRFRLDHITAIEQQYSDEKSYKQHGYRVLCIWFHGI-GWDTPIRGLYEALVQIDRRSLAERVRKKLD 584
BLAST of Death domain protein vs. TrEMBL
Match: A0A267EXT0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig016846g3 PE=4 SV=1) HSP 1 Score: 431.795 bits (1109), Expect = 1.382e-140 Identity = 251/599 (41.90%), Postives = 352/599 (58.76%), Query Frame = 3
Query: 84 SGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIF-NLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPT--------GNGFTPLHIVTQKS--------------------FAD----------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEE------SKQAVFDD---PDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELD 1718
S PKR +DDCDMVTSLQ LSK EL LHEAAR + + K+IK + DRTALHMAAS+GH E RILI GK SV++ DK+GM+PL+WA YFGH+EVV L+++ A I +RNK G +VHIAAE N +++ K + L+D + NGM+ ++A +K ++LI D+ D + H+A ++G+E + NL+ + +EL+++ D + P+HYA E GF VE+L+ GA+ + T N TP+ + + S FAD I+ L++AG DI+ N G T LH A L++ + V L+ D+ NNR QTPLH EQN+ + E LLL GA L+ DKTGKTPL++A +G I +VDMIIKAER ++ + + + E + + + + AF P Y N NI+ E ++ + ++ P Y L+EFNQPYA+EFKL+LWK+AF++LR+ EWKKLA +W F+ +HI AIE Q + + SYK HGYRVLCIWFHG+ DTP+RGLYEALV I RR LA+++R++LD
Sbjct: 5 SMPKRSEDDCDMVTSLQEPFLSKAELALHEAARSGNRTRVEKLIKVTGKIDCRNSL-DRTALHMAASKGHREIVRILIESGKASVEVTDKFGMSPLMWATYFGHIEVVNLLLDRSANIRRRNKLGMHVVHIAAEQNHCELVKIFINKTKKTLLNDTEKNGMTAVMIAAAKGNGEVVQSLISLGADLKIRDNRKRTVLHVAAESGNERVLDNLIADGPKMRELINERDDRGRMPIHYAVEKGFAGAVEILLAFGASPNDTTDSEEVETVANSATPIAVHPEMSPFLLAAREKKPNEDEQPAEAFADGAAPGEGGKPRPQHGEILRRLVQAGTDIDAVNSNGYTALHYAALNDDANAVYTLVHFGCDISAKNNRMQTPLHMAAEQNRLRAAEALLLSGAPLNIADKTGKTPLVLATQGGCICIVDMIIKAERHREKVQRVLKNEPNQWDSAAQADQLDAAAAFTPDGYENRSNINESENIDDELTESFILENGTAPAYRLREFNQPYADEFKLFLWKLAFDHLRYGEWKKLALFWRFRLDHITAIEQQYSDEKSYKQHGYRVLCIWFHGI-GWDTPIRGLYEALVQIDRRSLAERVRKKLD 601
BLAST of Death domain protein vs. TrEMBL
Match: A0A267EXN1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig016846g2 PE=4 SV=1) HSP 1 Score: 430.639 bits (1106), Expect = 3.811e-140 Identity = 251/599 (41.90%), Postives = 351/599 (58.60%), Query Frame = 3
Query: 84 SGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIF-NLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPT--------GNGFTPLHIVTQKS--------------------FAD----------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEE------SKQAVFDD---PDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELD 1718
S PKR +DDCDMVTSLQ LSK EL LHEAAR + + K+IK + DRTALHMAAS+GH E RILI GK SV++ DK+GM+PL+WA YFGH EVV L+++ A I +RNK G +VHIAAE N +++ K + L+D + NGM+ ++A +K ++LI D+ D + H+A ++G+E + NL+ + +EL+++ D + P+HYA E GF VE+L+ GA+ + T N TP+ + + S FAD I+ L++AG DI+ N G T LH A L++ + V L+ D+ NNR QTPLH EQN+ + E LLL GA L+ DKTGKTPL++A +G I +VDMIIKAER ++ + + + E + + + + AF P Y N NI+ E ++ + ++ P Y L+EFNQPYA+EFKL+LWK+AF++LR+ EWKKLA +W F+ +HI AIE Q + + SYK HGYRVLCIWFHG+ DTP+RGLYEALV I RR LA+++R++LD
Sbjct: 5 SMPKRSEDDCDMVTSLQEPFLSKAELALHEAARSGNRTRVEKLIKVTGKIDCRNSL-DRTALHMAASKGHREIVRILIESGKASVEVTDKFGMSPLMWATYFGHTEVVNLLLDRSANIRRRNKLGMHVVHIAAEQNHCELVKIFINKTKKTLLNDTEKNGMTAVMIAAAKGNGEVVQSLISLGADLKIRDNRKRTVLHVAAESGNERVLDNLIADGPKMRELINERDDRGRMPIHYAVEKGFAGAVEILLAFGASPNDTTDSEEVETVANSATPIAVHPEMSPFLLAAREKKPNEDEQPAEAFADGAAPGEGGKPRPQHGEILRRLVQAGTDIDAVNSNGYTALHYAALNDDSNAVYTLVHFGCDISAKNNRMQTPLHMAAEQNRLRAAEALLLSGAPLNIADKTGKTPLVLATQGGCICIVDMIIKAERHREKVQRVLKNEPNQWDSAAQADQLDAAAAFTPDGYENRSNINESENIDDELTESFILENGTAPAYRLREFNQPYADEFKLFLWKLAFDHLRYGEWKKLALFWRFRLDHITAIEQQYSDEKSYKQHGYRVLCIWFHGI-GWDTPIRGLYEALVQIDRRSLAERVRKKLD 601
BLAST of Death domain protein vs. TrEMBL
Match: A0A1I8HW97 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 444.506 bits (1142), Expect = 1.712e-134 Identity = 256/606 (42.24%), Postives = 358/606 (59.08%), Query Frame = 3
Query: 78 LDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIF-NLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQ-----------KSFAD----------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEE------SKQAVFDD---PDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELD------SEGGK-SKGNSSCIIH 1763
L S PKR +DDCDMVTSLQ LSK EL LHEAAR + + K+IK + DRTALHMAAS+GH E RILI GK SV++ DK+GM+PL+WA YFGH EVV L+++ A I +RNK G +VHIAAE N +++ K + L+D + NGM+ ++A +K ++LI D+ D + H+A ++G+E + NL+ + +EL+++ D + P+HYA E GF VE+L+ GA+ + T +P + + ++FAD I+ L++AG DI+ N G T LH A L++ + V L+ D+ NNR QTPLH EQN+ + E LLL GA L+ DKTGKTPL++A +G I +VDMIIKAER ++ + + + E + + + + AF P Y N NI+ E ++ + ++ P Y L+EFNQPYA+EFKL+LWK+AF++LR+ EWKKLA +W F+ +HI AIE Q + + SYK HGYRVLCIWFHG+ DTP+RGLYEALV I RR LA+++R++LD S G K SC IH
Sbjct: 1399 LSSMPKRSEDDCDMVTSLQEPFLSKAELALHEAARSGNRTRVEKLIKVTGKIDCRNSL-DRTALHMAASKGHREIVRILIESGKASVEVTDKFGMSPLMWATYFGHTEVVNLLLDRSANIRRRNKLGMHVVHIAAEQNHCELVKIFINKTKKTLLNDTEKNGMTAVMIAAAKGNGEVVQSLISLGADLKIRDNRKRTVLHVAAESGNERVLDNLIADGPKMRELINERDDRGRMPIHYAVEKGFAGAVEILLAFGASPNDTTDPEMSPFLLAAREKKPNEDEQPAEAFADGAAPGEGGKPRPQHGEILRRLVQAGTDIDAVNSNGYTALHYAALNDDSNAVYTLVHFGCDISAKNNRMQTPLHMAAEQNRLRAAEALLLSGAPLNIADKTGKTPLVLATQGGCICIVDMIIKAERHREKVQRVLKNEPNQWDSAAQADQLDAAAAFTPDGYENRSNINESENIDDELTESFILENGTAPAYRLREFNQPYADEFKLFLWKLAFDHLRYGEWKKLALFWRFRLDHITAIEQQYSDEKSYKQHGYRVLCIWFHGI-GWDTPIRGLYEALVQIDRRSLAERVRKKLDRSAEYYSAGRKIHHEGRSCTIH 2002
BLAST of Death domain protein vs. Ensembl Cavefish
Match: ankdd1a (ankyrin repeat and death domain containing 1A [Source:ZFIN;Acc:ZDB-GENE-070615-8]) HSP 1 Score: 280.411 bits (716), Expect = 1.967e-86 Identity = 175/533 (32.83%), Postives = 282/533 (52.91%), Query Frame = 3
Query: 144 LSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGV-ESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSK 1739
L ++E LH+AA++ND ++++I+K DR ALH AA G ++A R+L+ + VD D +GM LL A +FGHL+++Q LV GA ++ NK+G +++H AA+ ++ILE++ +L+ D +G + F LA + + LI DK A HLA KNGH + ++E E ++ + + LH A + G + V LL+E ++++ T T LH Q F I LL++AG ++ + + LH+A +N +V +L+D D+DI ++R QT LH E + E++L+ G NL +DK KT L +AARG+++++VDMIIKA+RF + +++ N D N+ + ++ +QP + + LWK+A L+ EWK+LA +W F HI AIE++ T SYK HG+R+L IW HGV S + P++GLYE L+ I R LA+ +R++ +++ G SK
Sbjct: 55 LLRSEKELHDAAKRNDTEKMQELIRKGVDPKAKNKM-DRKALHWAAGAGSVDALRLLL-DHDTMVDDMDSFGMNALLLAGWFGHLKILQILVSSGAKLNCENKKGLNLLHCAAQRGHIHILEFIVEDLEDVRLNRVDKSGKTAFHLAAEHGQLEVTEFLIGMGCARDLKDKEENTALHLAAKNGHTEVLQKILE---TGENTNERNIDGMTALHLAADGGHYECVRLLLEARCSINELTNRNMTALHCAAQHGFDRIAWLLVEAGISLDSVDANHTSALHLAVFNNSSEIVKILIDAECDLDIFDSRLQTALHIAAEHGRHKIAEMILIAGVNLRLLDKQEKTSLDIAARGNHVNVVDMIIKADRFYKWEQD---------------------NVSSDCDSIVGRNL---------------TFRQDHQPETQHIRSILWKLATKYLKPGEWKRLAQHWRFTDAHIRAIEHEWTGTKSYKEHGHRMLLIWLHGVLTSGENPIKGLYEGLMGISRMDLAESVRQQANADPGSSK 546
BLAST of Death domain protein vs. Ensembl Cavefish
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:NCBI gene;Acc:103046514]) HSP 1 Score: 247.284 bits (630), Expect = 8.766e-74 Identity = 169/507 (33.33%), Postives = 274/507 (54.04%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNA---WHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATL-SNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCII 1760
+RTALH A + +EA +L+ + + +D+ DK+G+T + AA+FG LE+++ LV+ GA N G +++H AA + I+EY+ + +LD +D +G P+ +A CV + L+E+ ++S +++ N+N HLA KNG LL++ E+ ++ + + ++ L+ A + V L+E + + T N +PLH V++K F ++ L+ GAD+N QN TPLH+A S LP + TLL+ + D DI ++ QT LH+ E K D VE++L G N+ D+ GKT L +AAR + +VDMIIKAER+ F P + + + D+ + K ++ ++ + +WK+A++ L+ +EWKKLA +WGF + + AIE Q T NSY+ HG R+L IW HGV +Q +P R LY+AL+++G KLA+KIR E + ++ N C I
Sbjct: 93 NRTALHYAVAFRSVEAVDVLL-KRRAKLDLQDKHGVTAIHLAAWFGSLEILKLLVQGGADQRIENSNGMNMMHCAAINDHTEIVEYIVDDLQMRELDKEDNHGNRPYAVAAEHGCVKLLQMLMEEPYNMSTMEE-NQNGDTPLHLAAKNGQLEAVQLLLD---NFEIRNETNHAGETALYLAAVGNHDECVLALLESDCDPNIFTLNRISPLHAVSEKGFVAVVKHLVDNGADMNLQNQHLQTPLHLAVKNSYLPVLHTLLV-SGCDTDITDHLGQTALHSAAELGKVDVVEMVLKAGVNMEIKDRQGKTALGVAARADIVIIVDMIIKAERY------------------------FSWLRSNPG------------ANETLHDEFPLTFKLDHRSETKQVRGVMWKLAYSLLKKNEWKKLAEHWGFTEQQVAAIEEQWTGPNSYQEHGNRMLLIWLHGVTMTQQSPGRELYQALIAVGNTKLAEKIRMEGEE---LTENNKKCAI 554
BLAST of Death domain protein vs. Ensembl Cavefish
Match: ank1a (ankyrin 1, erythrocytic a [Source:ZFIN;Acc:ZDB-GENE-041010-44]) HSP 1 Score: 146.362 bits (368), Expect = 3.452e-36 Identity = 104/331 (31.42%), Postives = 165/331 (49.85%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHE--NIFNLLIEMEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
D+T+LH AA GH E ++L+ E K + + G TPL AA GH + V+ L++ A +K K+G +H+AA+ V++ E + R + NG++P +AV N ++DV L + + H A +NG+ +I + ++EV L+ S++ +PLH A + G +V LLI + AN++ +G TPLH+V Q+ I +L+K GA + G TPLH+A MV LL A+++ TPLH +Q D V +LL GA + I G + L +A R YIS++D++
Sbjct: 442 DQTSLHCAARMGHKELVKLLL-EHKANPNSTTTAGHTPLHIAAREGHTQTVRILLDMNAQQTKMTKKGFTPLHVAAKYGKVDVAELLLE--RGANPNAAGKNGLTPLHVAVHHN-----------NLDVVNLLVSKGGSPHSAARNGYTPLHIASKQNQVEVASSLLQYGASANAESLQGVTPLHLAAQEGRADMVSLLISKQANVNLGNKSGLTPLHLVAQEGHVGIADILVKQGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQANVNGKTRAGYTPLHQAAQQGHTDIVTLLLKHGAQPNEITTNGTSALAIAKRLGYISVIDVL 758 HSP 2 Score: 142.895 bits (359), Expect = 4.611e-35 Identity = 87/323 (26.93%), Postives = 162/323 (50.15%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + H+ +L+ + S++ + G+TPL A++ GHL +V+ L++KGA + N + +H+A+ + E++ + +D + + + A K L+E + + H+A + GH +L++M + M K +PLH A + G + + ELL+E+GAN + NG TPLH+ + D++ LL+ G + G TPLHIA+ N + + LL A + + + TPLH ++ + D V +L+ + AN++ +K+G TPL + A+ ++ + D+++K
Sbjct: 345 TPLHIACKKNHLRVMDLLL-KHSASLEAVTESGLTPLHVASFMGHLNIVKILLQKGASPNASNVKVETPLHMASRAGHCEVAEFLLQNA--APVDAKAKDDQTSLHCAARMGHKELVKLLLEHKANPNSTTTAGHTPLHIAAREGHTQTVRILLDMNAQQTKMTK---KGFTPLHVAAKYGKVDVAELLLERGANPNAAGKNGLTPLHVAVHHNNLDVVNLLVSKGGSPHSAARNGYTPLHIASKQNQVEVASSLLQYGASANAESLQGVTPLHLAAQEGRADMVSLLISKQANVNLGNKSGLTPLHLVAQEGHVGIADILVK 661 HSP 3 Score: 134.035 bits (336), Expect = 3.736e-32 Identity = 87/325 (26.77%), Postives = 164/325 (50.46%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T LH+A+ GH+ +IL+ +G S + + TPL A+ GH EV +FL++ A + + K +H AA +++ + +H+ + G +P +A + + + L++ + +++ K H+A K G ++ LL+E K + +PLH A + + +V LL+ +G + NG+TPLHI ++++ ++ L++ GA N +++QG TPLH+A MV+LL+ A++++ N TPLH ++ +IL+ +GA++ + G TPL +A I MV +++ +
Sbjct: 378 TPLHVASFMGHLNIVKILLQKG-ASPNASNVKVETPLHMASRAGHCEVAEFLLQNAAPVDAKAKDDQTSLHCAARMGHKELVKLLL-EHK-ANPNSTTTAGHTPLHIAAREGHTQTVRILLDMNAQQTKMTKKGFTPLHVAAKYGKVDVAELLLERGANPNAAGK---NGLTPLHVAVHHNNLDVVNLLVSKGGSPHSAARNGYTPLHIASKQNQVEVASSLLQYGASANAESLQGVTPLHLAAQEGRADMVSLLISKQANVNLGNKSGLTPLHLVAQEGHVGIADILVKQGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQ 696 HSP 4 Score: 121.709 bits (304), Expect = 3.500e-28 Identity = 100/389 (25.71%), Postives = 166/389 (42.67%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGA------------------------------------VISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVP------------------------KELM------DKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+AA G + L+ G +V+ + G TPL AA HLEVV+FL+E GA V S G +HIAA +N+ + + +R ++ NG++P +A + V+ + L+++ + K H A +NGH I +L++ P ++L+ D + +PLH A G ++ ++L+++GA + NGFTPLHI +K+ ++ LL+K A + G TPLH+A+ ++V +LL A + N + +TPLH C+ E LL A + K +T L AAR + +V ++++
Sbjct: 78 TALHIAALAGQEQVVTELVNYG-ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQSIPTEVKPSAVSLANSYSFPLYLSTNASHITLKNVCSFITATGFTPLHIAAHYENLNVAQLLL--NRGANVNFTPKNGITPLHIASRRGNVIMVRLLLDRGATIDAKTKDELTPLHCAARNGHVRIIEILLDQGAPIQAKTKNGLSPIHMAAQGDHMDCVRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRMAKVLLDKGAKPNTRALNGFTPLHIACKKNHLRVMDLLLKHSASLEAVTESGLTPLHVASFMGHLNIVKILLQKGASPNASNVKVETPLHMASRAGHCEVAEFLLQNAAPVDAKAKDDQTSLHCAARMGHKELVKLLLE 463 HSP 5 Score: 95.1301 bits (235), Expect = 8.585e-20 Identity = 81/326 (24.85%), Postives = 151/326 (46.32%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVP----KELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T+ AA G+++ I G + ++ ++ G+ L A+ GH+++V L+ G V+ K+G +HIAA ++ + + ++ Q G +P +A +N + K L+E + S + +A LA N + F L + K + + ++ +PLH A + + +LL+ +GAN++ NG TPLHI +++ ++ LL+ GA I+ + TPLH A + ++ +LLD A + +P+H + + D V LL A + +I TPL +AA + M +++
Sbjct: 12 TSFLRAARSGNLDKALDHIKNG-IDINTANQNGLNGLHLASKEGHVKMVLELLHNGVVLETTTKKGNTALHIAALAGQEQVVTELV--NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQSIPTEVKPSAVSLA--NSYS--FPLYLSTNASHITLKNVCSFITATGFTPLHIAAHYENLNVAQLLLNRGANVNFTPKNGITPLHIASRRGNVIMVRLLLDRGATIDAKTKDELTPLHCAARNGHVRIIEILLDQGAPIQAKTKNGLSPIHMAAQGDHMDCVRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRMAKVLL 330 HSP 6 Score: 94.3597 bits (233), Expect = 1.269e-19 Identity = 71/266 (26.69%), Postives = 111/266 (41.73%), Query Frame = 3
Query: 540 LDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPT------------------------------------GNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
++ + NG++ LA + V L+ + + K A H+A G E + L+ ++ +PL+ A + +++V+ L+E GAN S PT GFTPLHI ++ LL+ GA++N G TPLHIA+ MV LLLD A +D E TPLH +EILL +GA + K G +P+ MAA+G ++ V +++
Sbjct: 36 INTANQNGLNGLHLASKEGHVKMVLELLHNGVVLETTTKKGNTALHIAALAGQEQVVTELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQSIPTEVKPSAVSLANSYSFPLYLSTNASHITLKNVCSFITATGFTPLHIAAHYENLNVAQLLLNRGANVNFTPKNGITPLHIASRRGNVIMVRLLLDRGATIDAKTKDELTPLHCAARNGHVRIIEILLDQGAPIQAKTKNGLSPIHMAAQGDHMDCVRQLLQ 298
BLAST of Death domain protein vs. Ensembl Cavefish
Match: ank3a (ankyrin 3a [Source:ZFIN;Acc:ZDB-GENE-060621-1]) HSP 1 Score: 145.976 bits (367), Expect = 4.863e-36 Identity = 95/328 (28.96%), Postives = 163/328 (49.70%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G+I +L+ G +VD + +TPL AA G+ +V+ L+++GA I + K G +H A ++E + R + + NG+SP +A + + + L++ D+ V + A H+A GH + ++++ K + + K +PLH AC+ +K++ELL++ GA+L T +G TP+H+ +I+ L GA N N++G T LH+A + +V LL N A +DI +QT LH K + V++LL +GA S +G TPL +A R + ++++
Sbjct: 211 TPLHIAAHYGNINVATLLLNRG-AAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLL--DRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIVD--------KKANPNAKALNGFTPLHIACKKNRVKVMELLLKHGASLQAVTESGLTPIHVAAFMGHENIVKQLTHHGASPNTTNVRGETALHMAARAGQADVVRYLLQNGAKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLE 527 HSP 2 Score: 137.117 bits (344), Expect = 4.246e-33 Identity = 101/358 (28.21%), Postives = 165/358 (46.09%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A + D+TALH+A+ G E ++L+ +G + G TPL A GH E L+E GA +S K+G +H+AA+ + + + +K D G++P +A + A L++ K H+A K I L+E + + SPLH A + G + +V LL+ + AN++ NG TPLH+ Q+ + +L+ GA+++ G TPLH+A MV+ LL+N A ++ TPLH +Q + +LL A+ + + G T L +A R YIS+VD +
Sbjct: 439 RGETALHMAARAGQADVVRYLLQNGAKVDIKAKD-DQTALHIASRLGKAEIVQLLLQKGAWA-SAATTSGYTPLHLAVREGHQETASLLLEHGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKR--AAPDTAGKTGLTPLHVAAHYDNQRVALLLLDHGASPHAAAKNGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTR---QGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLENQAKINSKTKSGYTPLHQAAQQGHTHIINMLLQHRASANELTLNGNTALSIARRLGYISVVDTL 789 HSP 3 Score: 135.191 bits (339), Expect = 1.848e-32 Identity = 96/354 (27.12%), Postives = 162/354 (45.76%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKL---DDQD----------------------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + ++ +L+ G S+ + G+TP+ AA+ GH +V+ L GA + N +G +H+AA +++ Y+ + + DDQ +G +P LAV + +A L+E +S K H+A K G LL++ + K + +PLH A ++ LL++ GA+ NG+TPLHI +K+ +I L++ GA+ N QG +PLH+A +V+LLL NA++++ N TPLH ++++ E+LL GA + KTG TPL +A + MV +++
Sbjct: 376 TPLHIACKKNRVKVMELLLKHG-ASLQAVTESGLTPIHVAAFMGHENIVKQLTHHGASPNTTNVRGETALHMAARAGQADVVRYLLQNGAKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLEHGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKRAAPDTAGK---TGLTPLHVAAHYDNQRVALLLLDHGASPHAAAKNGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTRQGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLE 725 HSP 4 Score: 129.413 bits (324), Expect = 1.373e-30 Identity = 92/323 (28.48%), Postives = 148/323 (45.82%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALHMAA G + R L+ G VDI K T L A+ G E+VQ L++KGA S G +H+A + L G +P +A + +AK L++K KT H+A ++ + LL++ K + +PLH A + ++I L+E GA + T G +PLH+ Q+ D++ LL+ A++N N G TPLH+A + + +LL++ A++D TPLH V LL A +++ K+G TPL AA+ + +++M+++
Sbjct: 442 TALHMAARAGQADVVRYLLQNG-AKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLE--HGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKRAAPDTAGKTGLTPLHVAAHYDNQRVALLLLDHGASPHAAAK---NGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTRQGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLENQAKINSKTKSGYTPLHQAAQQGHTHIINMLLQ 758 HSP 5 Score: 118.242 bits (295), Expect = 4.620e-27 Identity = 91/326 (27.91%), Postives = 154/326 (47.24%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELL--------IEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
AA G++E + G V ++I ++ G+ L A+ GH+EVV L++ GA + K+G +HIA+ +++ + ++ Q NG +P +A +N + + L+E S + +A + GH+ + +LL+E + ++ +L + LH A K LL +E + T +GFTPLHI ++ LL+ GA ++ TPLH+A +MV LLLD A +D TPLH G VE+LL RGA + + K G +PL MA +G +++ V ++++
Sbjct: 14 AARAGNLEKALDYLKTG-VDINICNQNGLNALHLASKEGHVEVVAELLKLGASVDAATKKGNTALHIASLAGQTDVVRELVTNG--ANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVESKVHTYTHTHSGFTPLHIAAHYGNINVATLLLNRGAAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 329 HSP 6 Score: 117.472 bits (293), Expect = 7.642e-27 Identity = 88/331 (26.59%), Postives = 158/331 (47.73%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNK--------NAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+A+ G + R L+ G +V+ + G TPL AA HLEVV+FL+E GA S + G + +A + ++ + D + + +A K+ SA L++ D + K + H+A G+ N+ LL+ + M + +D +PLH A + G +V+LL+++GA + T +G TPLH + ++ +L+ GA I + G +PLH+AT + + V LLL ++ +D + N T LH ++++ + AN + G TPL +A + + + ++++++K
Sbjct: 75 TALHIASLAGQTDVVRELVTNG-ANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLEN------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVESKVHTYTHTHSGFTPLHIAAHYGNINVATLLLNRGAAVDFMAR---NDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIVDKKANPNAKALNGFTPLHIACKKNRVKVMELLLK 395 HSP 7 Score: 114.775 bits (286), Expect = 5.460e-26 Identity = 85/319 (26.65%), Postives = 153/319 (47.96%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQ------DYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK---SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAA 1190
T L+MAA + H+E R L+ G S I + G TPL A GH +VV L+E + K +HIAA + + + + ++ + ++G +P +A + A L+ + V + + + H+A K G+ N+ LL++ K+D+ K +PLH +G ++VE+L+++GA + T NG +PLH+ TQ + + LL++ ++ T LH+A + +++D A+ + TPLH ++N+ +E+LL GA+L + ++G TP+ +AA
Sbjct: 108 TPLYMAAQENHLEVVRFLLEHG-ASQSIATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVESKVHTYTHTHSGFTPLHIAAHYGNINVATLLLNRGAAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGA------KIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIVDKKANPNAKALNGFTPLHIACKKNRVKVMELLLKHGASLQAVTESGLTPIHVAA 415 HSP 8 Score: 113.62 bits (283), Expect = 1.206e-25 Identity = 85/326 (26.07%), Postives = 154/326 (47.24%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDS-----SDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
ALH+A+ +GH+E L+ G SVD K G T L A+ G +VV+ LV GA ++ +++ G +++AA+ N + ++ ++ + +D G +P +A+ + L+E D K A H+A + LL++ + ++ K+ + S +PLH A G I + LL+ +GA + N TPLH+ ++ +++ LL+ GA I+ + G TPLH S +V +LLD A + +PLH + + + V++LL + ++ T L +AA + + +I+
Sbjct: 43 ALHLASKEGHVEVVAELLKLG-ASVDAATKKGNTALHIASLAGQTDVVRELVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATED--GFTPLAVALQQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVESKVHTYTHTHSGFTPLHIAAHYGNINVATLLLNRGAAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIV 361 HSP 9 Score: 73.9442 bits (180), Expect = 3.480e-13 Identity = 62/255 (24.31%), Postives = 110/255 (43.14%), Query Frame = 3
Query: 573 FLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDN-------------------------------NADMD------IINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
+L A + A ++ +D++ ++ NA HLA K GH + L+++ +D + LH A G +V L+ GAN++ + NGFTPL++ Q++ +++ L++ GA + G TPL +A +V+LLL+N NAD++ + TPLH + +LL RGA + + + TPL +AA+ +MV +++
Sbjct: 11 YLRAARAGNLEKALDYLKTGVDINICNQNGLNALHLASKEGHVEVVAELLKLGAS---VDAATKKGNTALHIASLAGQTDVVRELVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVESKVHTYTHTHSGFTPLHIAAHYGNINVATLLLNRGAAVDFMARNDITPLHVAAKRGNGNMVKLLL 262
BLAST of Death domain protein vs. Ensembl Cavefish
Match: ank3a (ankyrin 3a [Source:ZFIN;Acc:ZDB-GENE-060621-1]) HSP 1 Score: 145.591 bits (366), Expect = 5.830e-36 Identity = 95/328 (28.96%), Postives = 163/328 (49.70%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-----SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G+I +L+ G +VD + +TPL AA G+ +V+ L+++GA I + K G +H A ++E + R + + NG+SP +A + + + L++ D+ V + A H+A GH + ++++ K + + K +PLH AC+ +K++ELL++ GA+L T +G TP+H+ +I+ L GA N N++G T LH+A + +V LL N A +DI +QT LH K + V++LL +GA S +G TPL +A R + ++++
Sbjct: 239 TPLHIAAHYGNINVATLLLNRG-AAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLL--DRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIVD--------KKANPNAKALNGFTPLHIACKKNRVKVMELLLKHGASLQAVTESGLTPIHVAAFMGHENIVKQLTHHGASPNTTNVRGETALHMAARAGQADVVRYLLQNGAKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLE 555 HSP 2 Score: 137.117 bits (344), Expect = 3.307e-33 Identity = 101/358 (28.21%), Postives = 165/358 (46.09%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A + D+TALH+A+ G E ++L+ +G + G TPL A GH E L+E GA +S K+G +H+AA+ + + + +K D G++P +A + A L++ K H+A K I L+E + + SPLH A + G + +V LL+ + AN++ NG TPLH+ Q+ + +L+ GA+++ G TPLH+A MV+ LL+N A ++ TPLH +Q + +LL A+ + + G T L +A R YIS+VD +
Sbjct: 467 RGETALHMAARAGQADVVRYLLQNGAKVDIKAKD-DQTALHIASRLGKAEIVQLLLQKGAWA-SAATTSGYTPLHLAVREGHQETASLLLEHGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKR--AAPDTAGKTGLTPLHVAAHYDNQRVALLLLDHGASPHAAAKNGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTR---QGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLENQAKINSKTKSGYTPLHQAAQQGHTHIINMLLQHRASANELTLNGNTALSIARRLGYISVVDTL 817 HSP 3 Score: 134.806 bits (338), Expect = 1.988e-32 Identity = 96/354 (27.12%), Postives = 162/354 (45.76%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKL---DDQD----------------------------YNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + ++ +L+ G S+ + G+TP+ AA+ GH +V+ L GA + N +G +H+AA +++ Y+ + + DDQ +G +P LAV + +A L+E +S K H+A K G LL++ + K + +PLH A ++ LL++ GA+ NG+TPLHI +K+ +I L++ GA+ N QG +PLH+A +V+LLL NA++++ N TPLH ++++ E+LL GA + KTG TPL +A + MV +++
Sbjct: 404 TPLHIACKKNRVKVMELLLKHG-ASLQAVTESGLTPIHVAAFMGHENIVKQLTHHGASPNTTNVRGETALHMAARAGQADVVRYLLQNGAKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLEHGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKRAAPDTAGK---TGLTPLHVAAHYDNQRVALLLLDHGASPHAAAKNGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTRQGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLE 753 HSP 4 Score: 129.413 bits (324), Expect = 1.293e-30 Identity = 92/323 (28.48%), Postives = 148/323 (45.82%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALHMAA G + R L+ G VDI K T L A+ G E+VQ L++KGA S G +H+A + L G +P +A + +AK L++K KT H+A ++ + LL++ K + +PLH A + ++I L+E GA + T G +PLH+ Q+ D++ LL+ A++N N G TPLH+A + + +LL++ A++D TPLH V LL A +++ K+G TPL AA+ + +++M+++
Sbjct: 470 TALHMAARAGQADVVRYLLQNG-AKVDIKAKDDQTALHIASRLGKAEIVQLLLQKGAWASAATTSGYTPLHLAVREGHQETASLLLE--HGASLSAATKKGFTPLHVAAKYGQIEAAKLLLQKRAAPDTAGKTGLTPLHVAAHYDNQRVALLLLDHGASPHAAAK---NGYTPLHIAAKKNQLEIGTTLLEFGAETNAVTRQGISPLHLAAQEGSVDLVSLLLTKNANVNMGNKNGLTPLHLAAQEDRVGVAEVLLNHGAEVDAHTKTGYTPLHVACHYGNMKMVSFLLENQAKINSKTKSGYTPLHQAAQQGHTHIINMLLQ 786 HSP 5 Score: 124.02 bits (310), Expect = 5.934e-29 Identity = 90/318 (28.30%), Postives = 155/318 (48.74%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
AA G++E + G V ++I ++ G+ L A+ GH+EVV L++ GA + K+G +HIA+ +++ + + ++ Q NG +P +A +N + + L+E S + +A + GH+ + +LL+E + ++ +L + LH A K LL++ N + +GFTPLHI ++ LL+ GA ++ TPLH+A +MV LLLD A +D TPLH G VE+LL RGA + + K G +PL MA +G +++ V ++++
Sbjct: 50 AARAGNLEKALDYLKTG-VDINICNQNGLNALHLASKEGHVEVVAELLKLGASVDAATKKGNTALHIASLAGQTDVVRELVTNGAN--VNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFMARNDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 357 HSP 6 Score: 124.02 bits (310), Expect = 6.371e-29 Identity = 88/323 (27.24%), Postives = 158/323 (48.92%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+A+ G + R L+ G +V+ + G TPL AA HLEVV+FL+E GA S + G + +A + ++ + D + + +A K+ SA L++ D + K+ H+A G+ N+ LL+ + M + +D +PLH A + G +V+LL+++GA + T +G TPLH + ++ +L+ GA I + G +PLH+AT + + V LLL ++ +D + N T LH ++++ + AN + G TPL +A + + + ++++++K
Sbjct: 111 TALHIASLAGQTDVVRELVTNG-ANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLEN------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFMAR---NDITPLHVAAKRGNGNMVKLLLDRGAKIDAKTKDGLTPLHCGARSGHEQVVEMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHDVPVDDVTNDYLTALHVAAHCGHYKVAKVIVDKKANPNAKALNGFTPLHIACKKNRVKVMELLLK 423 HSP 7 Score: 83.5741 bits (205), Expect = 3.690e-16 Identity = 62/236 (26.27%), Postives = 110/236 (46.61%), Query Frame = 3
Query: 519 RKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
RKH + D N + +L A + A ++ +D++ ++ NA HLA K GH + L+++ +D + LH A G +V L+ GAN++ + NGFTPL++ Q++ +++ L++ GA + G TPL +A +V+LLL+N+ + LH ++ S +LL N K+G TPL +AA I++ +++
Sbjct: 31 RKHSREQKKKSDSN--ASYLRAARAGNLEKALDYLKTGVDINICNQNGLNALHLASKEGHVEVVAELLKLGAS---VDAATKKGNTALHIASLAGQTDVVRELVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLEHGASQSIATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV----RLPALHIAARKDDTKSAALLLQNDHNADVESKSGFTPLHIAAHYGNINVATLLL 257
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Match: ankdd1a (ankyrin repeat and death domain containing 1A [Source:ZFIN;Acc:ZDB-GENE-070615-8]) HSP 1 Score: 247.669 bits (631), Expect = 3.956e-75 Identity = 174/530 (32.83%), Postives = 272/530 (51.32%), Query Frame = 3
Query: 165 LHEAARQND----EMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSD---KSPLHYACENGFIKIVELLIEQGA--NLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGV-ESQDTPVRGLYEALVSIGRRKLADKIRRELDSE 1724
HEAA++ND E LL+K+ D+TALH AA G +A ++L+ E K +VD DKYGM PLL AA+FGHLEV++ LV G +S +NK G +I+H AA+ V ++Y ++ + +P+LLA + + L++ D A HLA K+GH L+E + P +D ++S + + LH A E G ++ V +L++ A +++ LH+ + I LLI DIN + + +PLH+A +N P +VT L++ A++++++ R QT LH E +S ++LL G +L+ +DK K+ L +AAR + +++VDMIIKA+R+ + + R A Q + N + E AV PD + + + LW +A + LR +EW++LA +W F I AI+ Q +YK H +R+L +W HGV E + P++ LYE LV IGRR LAD +RR+ E
Sbjct: 7 FHEAAKRNDVDEMEKLLKKVKVDAKNMR------DQTALHFAAGSGQEDAVKLLL-ERKANVDKGDKYGMNPLLIAAWFGHLEVLKRLVNGGGRVSSQNKNGLNILHCAAQRGHVETVKYTLESLEDLGIEGKTNAEKTPYLLAAEYGQLAVLELLMDYKCAQDVSDGEKNTAIHLAAKSGHMLSLEHLLE-KGPGRTLDFVNSQNANGNTALHLAAEGGHLECVRMLLDCEAICDINALNNESMNALHMAAKHGHEQIAKLLIDETIDINAISTKQASPLHLAVQNNYPIIVTFLVEAEANINLVDCRNQTALHIAAETGFQESADLLLAAGTDLTLLDKQKKSCLEVAARANQVNLVDMIIKADRY-------FTRRKVRNAKQEEGNNE-------------------ESVLGAVTFRPD------RRAETQHLRSVLWDLARDKLRPEEWQQLATHWKFTEAQIQAIQQQWEGKKTYKEHAHRMLLVWLHGVLEFNENPIKALYEGLVGIGRRDLADLMRRKAHEE 496
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000093.1 (pep scaffold:Pmarinus_7.0:GL477582:20502:66045:1 gene:ENSPMAG00000000080.1 transcript:ENSPMAT00000000093.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 148.288 bits (373), Expect = 1.012e-37 Identity = 92/325 (28.31%), Postives = 168/325 (51.69%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEM--EVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G++ +L+ G +VD + G+TPL AA G+ +V+ L+++GA I + + G +H AA ++E + R + + NG+SP +A + + L+ + V + H+A GH + LL++ E ++ +PLH AC+ IK++ELL++ GA++ T +G TP+H+ + +++ LL++ GA N N++G TPLH+A+ + +V LL + A + + +QTPLH K + V++LL RG++ + +G TPL A+R + + ++++
Sbjct: 214 TPLHIAAHYGNMNVATLLLNLG-AAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLE--RDAPILAKTKNGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGF-----TPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQRGSDPNAPTASGSTPLYFASREGHGDVASLLLE 530 HSP 2 Score: 134.035 bits (336), Expect = 4.898e-33 Identity = 95/323 (29.41%), Postives = 152/323 (47.06%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
D+T LH+A+ G E ++L+ G + P G TPL +A+ GH +V L+E GA IS K+G +HIA++ + + + K+ D + NG++P +A + A L++K K H+A K + +L+E+ + L +PLH A + G +V LL+ + A++S T G T +H+ Q+ ++ +L K AD+N TPLH+A+ MV LL N A ++ TPLH +Q V LL A+ + + G T L +A R YIS+VD +
Sbjct: 476 DQTPLHIASRLGKAEIVQLLLQRGS-DPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYGRLEVATLLLEKY--ASADPKGKNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLELGAETNM---LTQQGVAPLHLAAQEGHADMVALLLGRHASISLATKGGLTAMHLAAQEDKVNVAEILTKHKADVNTTTKLCYTPLHVASHYGNIKMVNFLLRNRALVNAKTRNGYTPLHQAAQQGHTHVVNALLQHEASPNELTANGNTALAIARRLGYISVVDTL 792 HSP 3 Score: 132.494 bits (332), Expect = 1.691e-32 Identity = 98/384 (25.52%), Postives = 178/384 (46.35%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHR--------------------HFKL-----------DDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE------------------------MEVPKELMDK------LDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA +G+ ++L+ G +D + G+TPL AA GH +V++ L+E+ A I + K G +H+A +G + ++ + + H+++ + + NG +P +A KN + + L++ + ++ H+A GH N+ LL++ +EV K L+ D++PLH A G +IV+LL+++G++ + PT +G TPL+ +++ D+ LL++ GADI+ +G TPLHIA+ + TLLL+ A D TPLH + +LL +GA+ + K G TPL +AA+ + + + ++++
Sbjct: 247 TPLHVAAKRGNNNMVKLLLDRG-AKIDTKTRDGLTPLHCAARSGHEKVIEMLLERDAPILAKTKNGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGFTPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQRGSDPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYGRLEVATLLLEKYASADPKGKNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLE 629 HSP 4 Score: 130.954 bits (328), Expect = 4.298e-32 Identity = 93/329 (28.27%), Postives = 161/329 (48.94%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+A+ GH+ ++L+ G S + + G TPL A+ G LEVV+ L++ GA + + ++ +HIA+ I++ + + R + +G +P A + A L+E D+S + K H+A K G +EV L++K S+D +PLH A K+ LL+++GA+ NG+TPLHI +K+ ++ +L++ GA+ N QG PLH+A MV LLL +A + + T +H +++K + EIL A+++ K TPL +A+ I MV+ +++
Sbjct: 412 TPIHVASFMGHLNVVQLLLQNG-ASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQ--RGSDPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYG---------RLEVATLLLEKYASADPKGKNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLELGAETNMLTQQGVAPLHLAAQEGHADMVALLLGRHASISLATKGGLTAMHLAAQEDKVNVAEILTKHKADVNTTTKLCYTPLHVASHYGNIKMVNFLLR 728 HSP 5 Score: 122.479 bits (306), Expect = 2.818e-29 Identity = 85/322 (26.40%), Postives = 155/322 (48.14%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T LH+AA GH ++L+ G + G TPL A ++V++ L++ GA I + G +H+A+ +N+++ + + + + G +P +A + K L++ V + ++ H+A + G I LL++ + +S +PL++A G + LL+E GA++S T GFTPLHI ++ ++ LL++ A + + G TPLH+AT + + LLLD A TPLH ++N+ + ++LL GA + + + G PL +AA+ + MV +++
Sbjct: 346 TPLHVAAHCGHYRVAKLLLDRGG-EPNARALNGFTPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNG--ASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQRGSDP---NAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYGRLEVATLLLEKYASADPKGKNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLELGAETNMLTQQGVAPLHLAAQEGHADMVALLL 661 HSP 6 Score: 117.087 bits (292), Expect = 1.481e-27 Identity = 101/422 (23.93%), Postives = 173/422 (41.00%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQG-----------------------------CDIVHIAAEGNFVNILEYMFRKHRH-------FKLDDQDYNGMSPFLLA---------------------VSKNCVLS------------AKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVP-----KELMDKLDSSDK-------------------------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
TALH+AA G + R+L+ E +++ + G TPL AA HLE+V+FL++ GA S + G +HIAA + N + +H H L+ +G +P +A ++N + K L+++ + + H A ++GHE + +L+E + P K + L + + +PLH A G ++ +LL+++G + NGFTPLHI +K+ ++ LL+K GA I+ G TP+H+A+ ++V LLL N A + N R +TPLH + + V+ LL GA + + +TPL +A+R +V ++++
Sbjct: 78 TALHIAALAGQTDIVRVLV-EFGANINAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESDTKGKVRLPALHIAARKDDTNAAALLL-QHEHNADVTSKMMLNQTTESGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLERDAPILAKTKNGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGFTPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQ 497 HSP 7 Score: 115.161 bits (287), Expect = 6.499e-27 Identity = 84/330 (25.45%), Postives = 150/330 (45.45%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILI-------FEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A +L+ K+ ++ + G TPL AA++G++ V L+ GA + + G +H+AA+ N+++ + R K+D + +G++P H A ++GHE + +L+E + P K + SPLH A + + V+LL+ + A + T + TPLH+ + LL+ G + N + + G TPLHIA N ++ LLL + A + TP+H + V++LL GA+ + + G+TPL MA+R + +V ++++
Sbjct: 174 ALHIAARKDDTNAAALLLQHEHNADVTSKMMLNQTTESGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLD--RGAKIDTKTRDGLTPL---------------------------------HCAARSGHEKVIEMLLERDAPILAKTK---NGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGFTPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQS 465 HSP 8 Score: 112.849 bits (281), Expect = 3.307e-26 Identity = 91/331 (27.49%), Postives = 156/331 (47.13%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILI-FEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGAN--------LSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T+ AA G++E R++ +G + ++ ++ G+ L A+ GH++VV L+++ A I K G +HIAA +I+ + ++ Q NG +P +A +N + K L++ + S + +A + GHE + LL+E + ++ +L + LH A LL++ N L++ T +GFTPLHI ++ LL+ GA ++ G TPLH+A +MV LLLD A +D TPLH +E+LL R A + K G +PL MA +G +++ V +++
Sbjct: 12 TSFLRAARNGNLE--RLMDHLKGGMDINTCNQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVE--FGANINAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESDTKGKV--RLPA-----LHIAARKDDTNAAALLLQHEHNADVTSKMMLNQTTESGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLERDAPILAKTKNGLSPLHMATQGEHLACVQLLL 331 HSP 9 Score: 89.7373 bits (221), Expect = 7.043e-19 Identity = 67/263 (25.48%), Postives = 120/263 (45.63%), Query Frame = 3
Query: 552 DYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKA-------------------------------GADINCQNM------QGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+ NG++ LA + V L++++ ++ K A H+A G +I +L+E ++ + +PL+ A + ++IV+ L++ GAN S T +GFTPL + Q+ ++ LL+++ AD+ + M G TPLHIA ++ TLLL+ A +D TPLH ++ + V++LL RGA + + G TPL AAR + +++M+++
Sbjct: 40 NQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVEFGAN---INAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESDTKGKVRLPALHIAARKDDTNAAALLLQHEHNADVTSKMMLNQTTESGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLE 299 HSP 10 Score: 69.3218 bits (168), Expect = 1.446e-12 Identity = 45/164 (27.44%), Postives = 91/164 (55.49%), Query Frame = 3
Query: 744 LMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
L+DK D++ + A NG ++ + ++ G +++ NG LH+ +++ D++ L+K A+I+ GNT LHIA L+ +V +L++ A+++ + TPL+ ++N + V+ LL GAN S + G TPL +A + + +V ++++++
Sbjct: 4 LLDKSDAA--TSFLRAARNGNLERLMDHLKGGMDINTCNQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVEFGANINAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESD 165
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000095.1 (pep scaffold:Pmarinus_7.0:GL477582:20897:60453:1 gene:ENSPMAG00000000080.1 transcript:ENSPMAT00000000095.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 147.902 bits (372), Expect = 1.187e-37 Identity = 92/325 (28.31%), Postives = 168/325 (51.69%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEM--EVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA G++ +L+ G +VD + G+TPL AA G+ +V+ L+++GA I + + G +H AA ++E + R + + NG+SP +A + + L+ + V + H+A GH + LL++ E ++ +PLH AC+ IK++ELL++ GA++ T +G TP+H+ + +++ LL++ GA N N++G TPLH+A+ + +V LL + A + + +QTPLH K + V++LL RG++ + +G TPL A+R + + ++++
Sbjct: 207 TPLHIAAHYGNMNVATLLLNLG-AAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLE--RDAPILAKTKNGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGF-----TPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQRGSDPNAPTASGSTPLYFASREGHGDVASLLLE 523 HSP 2 Score: 132.494 bits (332), Expect = 1.290e-32 Identity = 94/323 (29.10%), Postives = 150/323 (46.44%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
D+T LH+A+ G E ++L+ G + P G TPL +A+ GH +V L+E GA IS K+G +HIA++ + + + K+ NG++P +A + A L++K K H+A K + +L+E+ + L +PLH A + G +V LL+ + A++S T G T +H+ Q+ ++ +L K AD+N TPLH+A+ MV LL N A ++ TPLH +Q V LL A+ + + G T L +A R YIS+VD +
Sbjct: 469 DQTPLHIASRLGKAEIVQLLLQRGS-DPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYGRLEVATLLLEKYASADPKVAGQNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLELGAETNM---LTQQGVAPLHLAAQEGHADMVALLLGRHASISLATKGGLTAMHLAAQEDKVNVAEILTKHKADVNTTTKLCYTPLHVASHYGNIKMVNFLLRNRALVNAKTRNGYTPLHQAAQQGHTHVVNALLQHEASPNELTANGNTALAIARRLGYISVVDTL 787 HSP 3 Score: 132.109 bits (331), Expect = 1.816e-32 Identity = 85/323 (26.32%), Postives = 162/323 (50.15%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+AA +G+ ++L+ G +D + G+TPL AA GH +V++ L+E+ A I + K G +H+A +G + ++ + R +DD + ++P +A AK L+++ + + H+ACK + LL++ + S +P+H A G + +V+LL++ GA+ + G TPLH+ ++ +++ L+++GA + + + TPLHIA+ +V LLL +D + TPL+ + D +LL GA++S + K G TPL +A++ + + ++++
Sbjct: 240 TPLHVAAKRGNNNMVKLLLDRG-AKIDTKTRDGLTPLHCAARSGHEKVIEMLLERDAPILAKTKNGLSPLHMATQGEHLACVQLLLG--RQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGFTPLHIACKKNRIKVMELLLKHGAS---IHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQRGSDPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYGRLEVATLLLE 556 HSP 4 Score: 130.183 bits (326), Expect = 8.585e-32 Identity = 93/331 (28.10%), Postives = 161/331 (48.64%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK--------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+A+ GH+ ++L+ G S + + G TPL A+ G LEVV+ L++ GA + + ++ +HIA+ I++ + + R + +G +P A + A L+E D+S + K H+A K G +EV L++K S+D +PLH A K+ LL+++GA+ NG+TPLHI +K+ ++ +L++ GA+ N QG PLH+A MV LLL +A + + T +H +++K + EIL A+++ K TPL +A+ I MV+ +++
Sbjct: 405 TPIHVASFMGHLNVVQLLLQNG-ASSNATNVRGETPLHMASRAGQLEVVKTLLQSGARVGVKAREDQTPLHIASRLGKAEIVQLLLQ--RGSDPNAPTASGSTPLYFASREGHGDVASLLLENGADISPVTKKGFTPLHIASKYG---------RLEVATLLLEKYASADPKVAGQNGLTPLHVATHYDHQKVALLLLDKGASPHSTAKNGYTPLHIAAKKNQLEVGKVLLELGAETNMLTQQGVAPLHLAAQEGHADMVALLLGRHASISLATKGGLTAMHLAAQEDKVNVAEILTKHKADVNTTTKLCYTPLHVASHYGNIKMVNFLLR 723 HSP 5 Score: 120.553 bits (301), Expect = 1.015e-28 Identity = 85/323 (26.32%), Postives = 151/323 (46.75%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
ALH+AA + A +L+ + + + D+ K G TPL AA++G++ V L+ GA + + G +H+AA+ N+++ + R K+D + +G++P H A ++GHE + +L+E + P K + SPLH A + + V+LL+ + A + T + TPLH+ + LL+ G + N + + G TPLHIA N ++ LLL + A + TP+H + V++LL GA+ + + G+TPL MA+R + +V ++++
Sbjct: 175 ALHIAARKDDTNAAALLL-QHEHNADVTSKSGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLD--RGAKIDTKTRDGLTPL---------------------------------HCAARSGHEKVIEMLLERDAPILAKTK---NGLSPLHMATQGEHLACVQLLLGRQAPVDDVTLDYLTPLHVAAHCGHYRVAKLLLDRGGEPNARALNGFTPLHIACKKNRIKVMELLLKHGASIHTTTESGLTPIHVASFMGHLNVVQLLLQNGASSNATNVRGETPLHMASRAGQLEVVKTLLQS 458 HSP 6 Score: 114.775 bits (286), Expect = 8.222e-27 Identity = 89/323 (27.55%), Postives = 153/323 (47.37%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRIL-IFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T+ AA G++E R++ +G + ++ ++ G+ L A+ GH++VV L+++ A I K G +HIAA +I+ + ++ Q NG +P +A +N + K L++ + S + +A + GHE + LL+E + ++ +L + LH A LL++ N + +GFTPLHI ++ LL+ GA ++ G TPLH+A +MV LLLD A +D TPLH +E+LL R A + K G +PL MA +G +++ V +++
Sbjct: 13 TSFLRAARNGNLE--RLMDHLKGGMDINTCNQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVE--FGANINAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESDTKGKV--RLPA-----LHIAARKDDTNAAALLLQHEHNADVTSKSGFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLERDAPILAKTKNGLSPLHMATQGEHLACVQLLL 324 HSP 7 Score: 90.1225 bits (222), Expect = 4.428e-19 Identity = 70/297 (23.57%), Postives = 135/297 (45.45%), Query Frame = 3
Query: 432 VISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKA-------------------------------GADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+S ++ + A GN +++++ ++ + NG++ LA + V L++++ ++ K A H+A G +I +L+E ++ + +PL+ A + ++IV+ L++ GAN S T +GFTPL + Q+ ++ LL+++ AD+ ++ G TPLHIA ++ TLLL+ A +D TPLH ++ + V++LL RGA + + G TPL AAR + +++M+++
Sbjct: 4 ALSFQSDAATSFLRAARNGNLERLMDHLKGG---MDINTCNQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVEFGAN---INAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESDTKGKVRLPALHIAARKDDTNAAALLLQHEHNADVTSKS--GFTPLHIAAHYGNMNVATLLLNLGAAVDFTARNGITPLHVAAKRGNNNMVKLLLDRGAKIDTKTRDGLTPLHCAARSGHEKVIEMLLE 292 HSP 8 Score: 67.0106 bits (162), Expect = 7.663e-12 Identity = 41/149 (27.52%), Postives = 83/149 (55.70%), Query Frame = 3
Query: 789 ACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
A NG ++ + ++ G +++ NG LH+ +++ D++ L+K A+I+ GNT LHIA L+ +V +L++ A+++ + TPL+ ++N + V+ LL GAN S + G TPL +A + + +V ++++++
Sbjct: 18 AARNGNLERLMDHLKGGMDINTCNQNGLNALHLASKEGHVDVVTELLKREAEIDTATKVGNTALHIAALAGQTDIVRVLVEFGANINAQSQNGFTPLYMAAQENHLEIVKFLLDNGANQSVATEDGFTPLAVALQQGHEQVVGLLLESD 166
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007449.1 (pep scaffold:Pmarinus_7.0:GL478728:201453:233342:1 gene:ENSPMAG00000006704.1 transcript:ENSPMAT00000007449.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.109 bits (331), Expect = 2.658e-32 Identity = 92/353 (26.06%), Postives = 162/353 (45.89%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE------------------------MEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I +L+ G S++ + G+TP+ +A+ G+L +V L++ GA + N +G +H+AA ++ + R ++D + +P +A + + L++ H+A + GHE++ +L+E MEV L+ + S D +PLH A K+ LL++QGA+ NG+TPLHI +K +I L++ GA+ N QG PLH+ + +LLL AD++ +PLH +++K + EIL+ GA+++ K G TPL++A I MV+ +++
Sbjct: 17 TPLHIACKKNRIRVMELLLKYG-ASIEAVTESGLTPMHVSAFMGNLNIVLILLQGGASPNATNVRGETALHMAARAGQTEVVRSLLRNGA--QVDAKAREEQTPLHIAARLGKLEIVQLLLQHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQRFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLEYGAETNAITRQGVAPLHLGAQEGHADVASLLLARYADVNHATKSGLSPLHLAAQEDKVNVAEILVKHGAHVNATTKLGYTPLIVACHYGNIKMVNFLLQ 366 HSP 2 Score: 132.109 bits (331), Expect = 2.755e-32 Identity = 99/358 (27.65%), Postives = 166/358 (46.37%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A ++T LH+AA G +E ++L+ + S D G TPL AA GH +V L+E GA ++ K+G +H+A++ + + + + R D NG++P +A + A L+++ K H+A K I L+E + + +PLH + G + LL+ + A+++ T +G +PLH+ Q+ ++ +L+K GA +N G TPL +A MV LL + AD++ TPLH +Q V +LL GA +++ G T L +A R YIS+VD +
Sbjct: 80 RGETALHMAARAGQTEVVRSLLRNGAQVDAKARE-EQTPLHIAARLGKLEIVQLLL-QHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQ--RFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLEYGAET---NAITRQGVAPLHLGAQEGHADVASLLLARYADVNHATKSGLSPLHLAAQEDKVNVAEILVKHGAHVNATTKLGYTPLIVACHYGNIKMVNFLLQHGADVNSKTKNGYTPLHQAAQQGHTHIVNLLLKCGARPNDVTVNGNTALAIARRLGYISVVDTL 430 HSP 3 Score: 107.457 bits (267), Expect = 2.000e-24 Identity = 81/325 (24.92%), Postives = 145/325 (44.62%), Query Frame = 3
Query: 357 GMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE-MEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQ-----------KSFAD----------------------IILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
G TPL A + V++ L++ GA I + G +H++A +NI+ + + + + G + +A ++L+ V + + H+A + G I LL++ M P D S+ +PLH A G + +L+E GA+L+ T GFTPLH+ ++ + FA + LLL+ GA + G TPLHIA + + T LL+ A+ + I + PLH G ++ D +LL R A++++ K+G +PL +AA+ +++ ++++K
Sbjct: 15 GFTPLHIACKKNRIRVMELLLKYGASIEAVTESGLTPMHVSAFMGNLNIVLILLQGGA--SPNATNVRGETALHMAARAGQTEVVRSLLRNGAQVDAKAREEQTPLHIAARLGKLEIVQLLLQHMASP----DAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQRFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLEYGAETNAITRQGVAPLHLGAQEGHADVASLLLARYADVNHATKSGLSPLHLAAQEDKVNVAEILVK 333 HSP 4 Score: 99.3673 bits (246), Expect = 6.878e-22 Identity = 67/272 (24.63%), Postives = 129/272 (47.43%), Query Frame = 3
Query: 414 LVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
L++KGA + R G +HIA + N + ++E + + ++ +G++P ++ + L++ + + + A H+A + G + L+ +D +++PLH A G ++IV+LL++ A+ T NG+TPLH+ ++ D+ +L++ GA + +G TPLH+A+ + +LLL A D TPLH + +LL +GA+ K G TPL +AA+ + + +++
Sbjct: 1 LLDKGANPNVRALNGFTPLHIACKKNRIRVMELLLKYGA--SIEAVTESGLTPMHVSAFMGNLNIVLILLQGGASPNATNVRGETALHMAARAGQTEVVRSLLRNGAQ---VDAKAREEQTPLHIAARLGKLEIVQLLLQHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQRFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLE 267
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007446.1 (pep scaffold:Pmarinus_7.0:GL478728:200023:240674:1 gene:ENSPMAG00000006704.1 transcript:ENSPMAT00000007446.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.109 bits (331), Expect = 3.094e-32 Identity = 92/353 (26.06%), Postives = 162/353 (45.89%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE------------------------MEVPKELMDKLDSSDK------SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH+A + I +L+ G S++ + G+TP+ +A+ G+L +V L++ GA + N +G +H+AA ++ + R ++D + +P +A + + L++ H+A + GHE++ +L+E MEV L+ + S D +PLH A K+ LL++QGA+ NG+TPLHI +K +I L++ GA+ N QG PLH+ + +LLL AD++ +PLH +++K + EIL+ GA+++ K G TPL++A I MV+ +++
Sbjct: 107 TPLHIACKKNRIRVMELLLKYG-ASIEAVTESGLTPMHVSAFMGNLNIVLILLQGGASPNATNVRGETALHMAARAGQTEVVRSLLRNGA--QVDAKAREEQTPLHIAARLGKLEIVQLLLQHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQRFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLEYGAETNAITRQGVAPLHLGAQEGHADVASLLLARYADVNHATKSGLSPLHLAAQEDKVNVAEILVKHGAHVNATTKLGYTPLIVACHYGNIKMVNFLLQ 456 HSP 2 Score: 131.724 bits (330), Expect = 3.353e-32 Identity = 99/358 (27.65%), Postives = 166/358 (46.37%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A ++T LH+AA G +E ++L+ + S D G TPL AA GH +V L+E GA ++ K+G +H+A++ + + + + R D NG++P +A + A L+++ K H+A K I L+E + + +PLH + G + LL+ + A+++ T +G +PLH+ Q+ ++ +L+K GA +N G TPL +A MV LL + AD++ TPLH +Q V +LL GA +++ G T L +A R YIS+VD +
Sbjct: 170 RGETALHMAARAGQTEVVRSLLRNGAQVDAKARE-EQTPLHIAARLGKLEIVQLLL-QHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQ--RFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLEYGAETNAITR---QGVAPLHLGAQEGHADVASLLLARYADVNHATKSGLSPLHLAAQEDKVNVAEILVKHGAHVNATTKLGYTPLIVACHYGNIKMVNFLLQHGADVNSKTKNGYTPLHQAAQQGHTHIVNLLLKCGARPNDVTVNGNTALAIARRLGYISVVDTL 520 HSP 3 Score: 121.324 bits (303), Expect = 7.372e-29 Identity = 81/295 (27.46%), Postives = 147/295 (49.83%), Query Frame = 3
Query: 357 GMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERF 1241
G+TPL AA GH +VV+ L+E+GA I + K G +H+A +G+ V ++ + + +DD + ++ +A +AK L++K + + H+ACK + LL++ ++ + S +P+H + G + IV +L++ GA+ + G T LH+ + +++ L++ GA ++ + + TPLHIA +V LLL + A D + TPLH + D ILL GA+L+ K G TPL +A++ + + +++ +RF
Sbjct: 6 GLTPLHCAARSGHEQVVEILLEQGAPILAKTKNGLSPLHMATQGDHVECVQVLMQYRA--PVDDITLDYLTALHVAAHCGHYRTAKVLLDKGANPNVRALNGFTPLHIACKKNRIRVMELLLKYGAS---IEAVTESGLTPMHVSAFMGNLNIVLILLQGGASPNATNVRGETALHMAARAGQTEVVRSLLRNGAQVDAKAREEQTPLHIAARLGKLEIVQLLLQHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLL--QRF 293 HSP 4 Score: 114.005 bits (284), Expect = 1.635e-26 Identity = 88/353 (24.93%), Postives = 157/353 (44.48%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI------------------------EMEVPKELM------DKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T LH AA GH + IL+ +G + K G++PL A H+E VQ L++ A + +H+AA + + K + + + NG +P +A KN + + L++ + + ++ H++ G+ NI +L+ + EV + L+ D +++PLH A G ++IV+LL++ A+ T NG+TPLH+ ++ D+ +L++ GA + +G TPLH+A+ + +LLL A D TPLH + +LL +GA+ K G TPL +AA+ + + +++
Sbjct: 8 TPLHCAARSGHEQVVEILLEQG-APILAKTKNGLSPLHMATQGDHVECVQVLMQYRAPVDDITLDYLTALHVAAHCGHYRTAKVLLDKGANPNV--RALNGFTPLHIACKKNRIRVMELLLKYGASIEAVTESGLTPMHVSAFMGNLNIVLILLQGGASPNATNVRGETALHMAARAGQTEVVRSLLRNGAQVDAKAREEQTPLHIAARLGKLEIVQLLLQHMASPDAATSNGYTPLHVAAREGHEDVTAILLEHGASLAVTTKKGFTPLHVASKYGKMEVASLLLQRFASPDAAGKNGLTPLHVASHYDNQKVALLLLDQGASPHATAKNGYTPLHIAAKKDQLEIATTLLE 357
BLAST of Death domain protein vs. Ensembl Yeast
Match: AKR1 (Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant [Source:SGD;Acc:S000002672]) HSP 1 Score: 62.003 bits (149), Expect = 1.897e-10 Identity = 41/143 (28.67%), Postives = 68/143 (47.55%), Query Frame = 3
Query: 774 SPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLI-----KAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMA 1187
+PLH+A G++ IV+ L++ GA+ + GF LH+ S ++L ++ K DI+C++ +G T L A V LL A + I + TPLH G + + ++ L+ GA+ TGK +A
Sbjct: 145 TPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQKTDTGKDCFAIA 287 HSP 2 Score: 51.2174 bits (121), Expect = 3.635e-7 Identity = 38/161 (23.60%), Postives = 71/161 (44.10%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGM---TPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAA-EGNFVNILEYMFR--KHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIE 725
T LH A+ + L+ +G D+ + G TPL WAA +G++ +V FL++ GA + + QG +++H++ N + +L +F +D +D G + L A + L+ L++ + D H G ++ LI+
Sbjct: 111 TGLHWASINNRLSVVDFLVSQG---ADVNARAGALHATPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQ 268 HSP 3 Score: 47.7506 bits (112), Expect = 4.378e-6 Identity = 60/248 (24.19%), Postives = 100/248 (40.32%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGK---VSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKR-NKQGCDIVHIAAEGNFVNILEYMFRKHRHFKL-DDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIA 989
T H A +G + + +I GK V+ D +T L WA+ L VV FLV +GA ++ R +H AA +V I++++ + + DDQ +N + L+V+ + ++ ++ + LD +D D ++ L +A G V L++ GA++ GFTPLH T K ++ LI+ GAD + G IA
Sbjct: 75 TRYHTACQRGDLATVKEMI-HGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHATPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLH---LSVNSSNIMLVLYVLFNVVSKGLLD-------------------------------IDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQKTDTGKDCFAIA 287
BLAST of Death domain protein vs. Ensembl Yeast
Match: AKR2 (Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication [Source:SGD;Acc:S000005560]) HSP 1 Score: 60.077 bits (144), Expect = 6.668e-10 Identity = 56/195 (28.72%), Postives = 94/195 (48.21%), Query Frame = 3
Query: 681 ACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTG-NGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLS-NLPSMVTLLL-----DNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMV-DMIIKAERF 1241
A K+G + ++E D++D + S LH+AC N + + L+ +GAN ++ G G T LH + I+ LL+K GAD ++ QG +H + S N+ +V +L ++N D+D +N +TPL Q +VE+LL G+ ++ D G L A G ++ D+I+ F
Sbjct: 57 AAKDGDLKVVKDVVESGAVDINNDRID--ELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANF 249 HSP 2 Score: 53.5286 bits (127), Expect = 7.368e-8 Identity = 44/188 (23.40%), Postives = 88/188 (46.81%), Query Frame = 3
Query: 171 EAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFV----NILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI 722
EAA+ D +++ +++ A ++N + + LH A + L+ G G T L WAA +G++ +V L++ GA + +++QG +I+H + + + +L ++ + + +D +D N +P L A + L+ + L++ V+ D NA H A G + + LI
Sbjct: 56 EAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLI 243
BLAST of Death domain protein vs. Ensembl Yeast
Match: NAS6 (Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6 [Source:SGD;Acc:S000003464]) HSP 1 Score: 56.225 bits (134), Expect = 2.096e-9 Identity = 45/155 (29.03%), Postives = 72/155 (46.45%), Query Frame = 3
Query: 777 PLHYAC-ENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNM---QGNTPLHIATLSNLPSMVTLLLDN--NADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
PLH AC EN F K+ ELL + + L + +G PLH +I L+ ++N + G TP HIA +V L D D++ I N+ T LH V + + + L+ GA++ DK + PL AA + +++++
Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 HSP 2 Score: 51.2174 bits (121), Expect = 1.173e-7 Identity = 44/162 (27.16%), Postives = 76/162 (46.91%), Query Frame = 3
Query: 693 GHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQ--GANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLD-NNADMDIINNREQTPLHAGVEQNKCDSVEILLLR-GANLSNIDKTG 1166
HE LL +ME L D D S +P H AC G +++V+ L ++ +L+K T G T LH+ K + ++ LI+ GA + ++ PLH A ++ LL + ++ + + TPL + + D+ +L+ + GA +D G
Sbjct: 48 AHEITSFLLSKME-NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208
BLAST of Death domain protein vs. Ensembl Yeast
Match: HOS4 (Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate [Source:SGD;Acc:S000001374]) HSP 1 Score: 56.9954 bits (136), Expect = 6.140e-9 Identity = 31/68 (45.59%), Postives = 45/68 (66.18%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEG-KVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGC 461
TALH AA QGHIE +LI G V++ + +G TPL+ A+ GHL+VV++L++ GA + RN +G
Sbjct: 366 TALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGL 433 HSP 2 Score: 50.447 bits (119), Expect = 7.087e-7 Identity = 37/110 (33.64%), Postives = 56/110 (50.91%), Query Frame = 3
Query: 651 DKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGA--NLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNT 974
D + +AC G ++ +IE E ++ D+ D++ + LH A G I+IVELLIE GA N+ G TPL + D++ L+K GAD +N +G T
Sbjct: 327 DSGGRTRLQIACDKGKYDVVKKMIE-EGGYDINDQ-DNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLT 434 HSP 3 Score: 48.9062 bits (115), Expect = 1.894e-6 Identity = 36/95 (37.89%), Postives = 48/95 (50.53%), Query Frame = 3
Query: 867 GFTPLHIVTQKSFADIILLLIKAGA-DINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDI--INNREQTPLHAGVEQNKCDSVEILLLRGAN 1142
G T L I K D++ +I+ G DIN Q+ GNT LH A L +V LL++N AD++I I TPL D V+ LL GA+
Sbjct: 330 GRTRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGAD 424
BLAST of Death domain protein vs. Ensembl Yeast
Match: AVO2 (Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth [Source:SGD;Acc:S000004672]) HSP 1 Score: 55.4546 bits (132), Expect = 1.365e-8 Identity = 45/154 (29.22%), Postives = 74/154 (48.05%), Query Frame = 3
Query: 483 EGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNK--NAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAG 938
EGN + I++ + R++ + NG S A L LI+ D +L KT K HLA GHE +LL++ + P+ ++ + ++P+H AC N + + + LLI GA+L NG TPLH+ + + +L+ G
Sbjct: 15 EGNLL-IVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQ-QFPR-FINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165 HSP 2 Score: 47.3654 bits (111), Expect = 4.213e-6 Identity = 39/136 (28.68%), Postives = 68/136 (50.00%), Query Frame = 3
Query: 741 ELMDKLDSSDK-SPLHYACENGFIKIVELLIEQGANLSK--PTGNGFTPLHIVTQKSFADIILLLIKAGAD-INCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRG 1136
+L+ +DS + S LHYA +G I LI+ G + + T G T +H+ K + LL++ IN + G P+HIA +++ ++LL+ AD+ +++ TPLH +E +++LL G
Sbjct: 30 DLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165
BLAST of Death domain protein vs. Ensembl Nematostella
Match: EDO38725 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC11]) HSP 1 Score: 85.5001 bits (210), Expect = 6.373e-19 Identity = 74/262 (28.24%), Postives = 112/262 (42.75%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADM 1046
+ALH A +EA LI G + D+ TPL A G +EV + LVEKGA + K+N +G +H+AA + L+++ K +D++D++ +PFL AV+ +A L+EKD EN KSPLH AC G VE L G + ++ G + LH+ F ++ L++ GADIN ++ TPL A + LL + A +
Sbjct: 10 SALHHATRYNRVEAMAELIRNGSIE-DLS-----TPLHVACKKGSMEVGRLLVEKGAALDKKNDKGETPLHMAACIGSFDALKFLLSKG--VAIDERDFSHRTPFLSAVAAGRTENAMLLLEKD----------------------EN---------------------QKSPLHLACAAGRALHVEALTRAGLSTNERDEEGQSALHMAALSGFRKVVTQLLRYGADINARDSNRWTPLMCAAKTGSVKTCMELLQSGASI 220 HSP 2 Score: 69.3218 bits (168), Expect = 1.801e-13 Identity = 52/198 (26.26%), Postives = 91/198 (45.96%), Query Frame = 3
Query: 639 VSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSD-KSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
++++D T +A H H +N +E EL+ D +PLH AC+ G +++ LL+E+GA L K G TPLH+ D + L+ G I+ ++ TP A + LLL+ + + +++PLH + VE L G + + D+ G++ L MAA + +V +++
Sbjct: 1 LNKMDDTGFSALH------HATRYN---RVEAMAELIRNGSIEDLSTPLHVACKKGSMEVGRLLVEKGAALDKKNDKGETPLHMAACIGSFDALKFLLSKGVAIDERDFSHRTPFLSAVAAGRTENAMLLLEKDEN-------QKSPLHLACAAGRALHVEALTRAGLSTNERDEEGQSALHMAALSGFRKVVTQLLR 182 HSP 3 Score: 60.8474 bits (146), Expect = 1.782e-10 Identity = 56/237 (23.63%), Postives = 102/237 (43.04%), Query Frame = 3
Query: 435 ISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANL 1145
++K + G +H A N V + + R + ++D +P +A K + + L+EK + + + + H+A G + L+ V +D+ D S ++P A G + LL+E+ N +PLH+ A + L +AG N ++ +G + LH+A LS +VT LL AD++ ++ TPL + + LL GA++
Sbjct: 1 LNKMDDTGFSALHHATRYNRVEAMAELIR---NGSIEDLS----TPLHVACKKGSMEVGRLLVEKGAALDKKNDKGETPLHMAACIGSFDALKFLLSKGVA---IDERDFSHRTPFLSAVAAGRTENAMLLLEKDENQK-------SPLHLACAAGRALHVEALTRAGLSTNERDEEGQSALHMAALSGFRKVVTQLLRYGADINARDSNRWTPLMCAAKTGSVKTCMELLQSGASI 220
BLAST of Death domain protein vs. Ensembl Nematostella
Match: EDO39113 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SB41]) HSP 1 Score: 83.5741 bits (205), Expect = 1.242e-18 Identity = 53/175 (30.29%), Postives = 88/175 (50.29%), Query Frame = 3
Query: 681 ACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLS---KPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLL-DNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAAR 1193
AC++G ++ L+ + ++ LD+ SPLHYA + IV++L++ GA++ P+ P+ + + + +L++AGAD+N N G T LH AT MV LLL D D+++++ T LH ++ LL GAN++ D G T +AAR
Sbjct: 2 ACRDGRKDCVRKLLRGNLTN--LNTLDADGFSPLHYATTTNHVDIVQMLLDAGADVDVRGSPSIQRIPPIICAAKFNAIESCRVLLRAGADVNITNCYGQTALHHATRRGHSKMVELLLRDGQMDVNVVDRDNTTSLHVAAMIGSNPIIKTLLFCGANITAKDNDGFTAFHLAAR 174 HSP 2 Score: 60.4622 bits (145), Expect = 1.243e-10 Identity = 48/224 (21.43%), Postives = 92/224 (41.07%), Query Frame = 3
Query: 276 AASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI---EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAG 938
A G + R L+ +++ D G +PL +A H+++VQ L++ GA + R + P + A N + S + L+ DV+ + + A H A + GH + LL+ +M+V + +D + + LH A G I++ L+ GAN++ +GFT H+ ++ +++ L++ G
Sbjct: 2 ACRDGRKDCVRKLLRGNLTNLNTLDADGFSPLHYATTTNHVDIVQMLLDAGADVDVRGSPSIQRI--------------------------------PPIICAAKFNAIESCRVLLRAGADVNITNCYGQTALHHATRRGHSKMVELLLRDGQMDV-----NVVDRDNTTSLHVAAMIGSNPIIKTLLFCGANITAKDNDGFTAFHLAAREGEEEVLQTLLRTG 188 HSP 3 Score: 48.1358 bits (113), Expect = 1.839e-6 Identity = 26/88 (29.55%), Postives = 48/88 (54.55%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFR 521
+TALH A +GH + +L+ +G++ V++ D+ T L AA G +++ L+ GA I+ ++ G H+AA +L+ + R
Sbjct: 99 QTALHHATRRGHSKMVELLLRDGQMDVNVVDRDNTTSLHVAAMIGSNPIIKTLLFCGANITAKDNDGFTAFHLAAREGEEEVLQTLLR 186
BLAST of Death domain protein vs. Ensembl Nematostella
Match: EDO38702 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC57]) HSP 1 Score: 87.0409 bits (214), Expect = 3.817e-18 Identity = 93/398 (23.37%), Postives = 167/398 (41.96%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVS---------VDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGA----VISKRNKQGCDIVHIAAEGNFVNI----LEYM-FRKHRHFK-----------------------LDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNA-----------------------WHLA---CKNGHENIFN-LLIEMEVPKELM-------DKLDSSDKSPLHYACENGFIKIVELLIEQG-ANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
T LH A +G++ ++L ++ V D+ T L A GH ++ + +EKGA V +NK + +A E FV I L+Y+ F K K ++ +D + +P ++A KN V + + L++ D++ D ++N+ W + C NG N L++ + + +L+ D + D +P+HYA + G ++ V L+++ A ++ G TPLH+ A ++ L+ G I+ +N TPL A + + +LLD +A +D + + TPLH + + V++LL R AN++ D G+ L +A S+ + II
Sbjct: 39 TPLHFACMEGNLGVAKLLFVAAELRGGWSTVSKMVTDQDREEQTALHLAVEGGHGDLAKLCLEKGANVNAVKESKNKTFHKTIVVARECIFVMIKVSKLKYLSFCKSEKIKREILLYFFDVVIIICYIIRFRACIECRDKDKDTPLMIAAEKNHVDTVRTLLQHGADIAAKDINDRNSVFRAAAEGCMETLEAALEHQKPVWTICDDVCLNGLVGGSNKLILVLRISSQLLLDNGACIDSKNDEDITPIHYAAKFGRVRTVCALLKRDPAIINDEDGASNTPLHLAALHGHAAVVKELLYRGGAIDARNATLWTPLDCAAARGMVEVANILLDEDAPVDPTDKAKTTPLHLASREGHVEMVKLLLSRKANITLTDSAGRNCLDIAIESSHKEVAVAII 436 HSP 2 Score: 60.4622 bits (145), Expect = 1.033e-9 Identity = 54/219 (24.66%), Postives = 102/219 (46.58%), Query Frame = 3
Query: 564 MSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLI---EME-----VPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLS--KPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAA 1190
M+P +A S C+ AK L+E D+ LD+ H AC G+ + LL E+ V K + D+ D +++ LH A E G + +L +E+GAN++ K + N IV + +++ + K C++ + + + ++ ++ ++ A ++ + + TPL E+N D+V LL GA+++ D + + AA
Sbjct: 5 MTPLHVACSHGCIPVAKCLVEAGADLRSLDEEQMTPLHFACMEGNLGVAKLLFVAAELRGGWSTVSKMVTDQ-DREEQTALHLAVEGGHGDLAKLCLEKGANVNAVKESKNKTFHKTIVVARECIFVMIKVSKLKYLSFCKSEKIKREI-LLYFFDVVIIICYIIRFRACIECRDKDKDTPLMIAAEKNHVDTVRTLLQHGADIAAKDINDRNSVFRAA 221 HSP 3 Score: 53.5286 bits (127), Expect = 1.854e-7 Identity = 58/276 (21.01%), Postives = 113/276 (40.94%), Query Frame = 3
Query: 315 IFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHF--KLDDQDYNGMSP------FLLAVSKNCVLSAKALIEK--DIDVSQL--------------------------DKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDN 1034
I + ++ DK TPL+ AA H++ V+ L++ GA I+ ++ + V AA + LE + DD NG+ +L +S +L A I+ D D++ + D + HLA +GH + E+ +D +++ +PL A G +++ +L+++ A + TPLH+ +++ +++ LL+ A+I + G L IA S+ + ++D+
Sbjct: 166 IIRFRACIECRDKDKDTPLMIAAEKNHVDTVRTLLQHGADIAAKDINDRNSVFRAAAEGCMETLEAALEHQKPVWTICDDVCLNGLVGGSNKLILVLRISSQLLLDNGACIDSKNDEDITPIHYAAKFGRVRTVCALLKRDPAIINDEDGASNTPLHLAALHGHAAVVK---ELLYRGGAIDARNATLWTPLDCAAARGMVEVANILLDEDAPVDPTDKAKTTPLHLASREGHVEMVKLLLSRKANITLTDSAGRNCLDIAIESSHKEVAVAIIDH 438 HSP 4 Score: 49.6766 bits (117), Expect = 2.339e-6 Identity = 44/179 (24.58%), Postives = 76/179 (42.46%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMD---KLDSSDKSPL 782
D T +H AA G + L+ ++ D TPL AA GH VV+ L+ +G I RN + AA V + + + +D D +P LA + V K L+ + +++ D +N +A ++ H+ + +I+ K+ M KL ++ SP+
Sbjct: 283 DITPIHYAAKFGRVRTVCALLKRDPAIINDEDGASNTPLHLAALHGHAAVVKELLYRGGAIDARNATLWTPLDCAAARGMVEVANILLDE--DAPVDPTDKAKTTPLHLASREGHVEMVKLLLSRKANITLTDSAGRNCLDIAIESSHKEVAVAIIDHVDWKQAMRNRCKLGNAITSPM 459
BLAST of Death domain protein vs. Ensembl Nematostella
Match: EDO34863 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SN65]) HSP 1 Score: 81.2629 bits (199), Expect = 6.445e-18 Identity = 51/161 (31.68%), Postives = 84/161 (52.17%), Query Frame = 3
Query: 747 MDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGA-DINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNRE-QTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+D ++ ++PLH A IV+ LI GAN + P NG TP H+ Q+S + L + D N +N +G PLHIA + LL+ N A++D + + +TPLH +E+N ++ LL A+++ D +G +P+ MA R + V ++
Sbjct: 6 LDIYNNLRQTPLHIAVITDQPDIVKCLIYAGANPNLPDRNGQTPAHLACQRSAVRCLYELTSSSLLDYNIRNFEGLMPLHIAVAKRDKYAIALLVQNGANVDCKDGKSGKTPLHHAIERNDLQIIKTLLDMSADINATDFSGVSPMAMANRRGLANAVRLL 166 HSP 2 Score: 56.6102 bits (135), Expect = 2.423e-9 Identity = 42/158 (26.58%), Postives = 75/158 (47.47%), Query Frame = 3
Query: 675 HLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIK-IVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQ-GNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGAN 1142
H+A +I LI L D+ + ++P H AC+ ++ + EL + + G PLHI K I LL++ GA+++C++ + G TPLH A N ++ LLD +AD++ + +P+ + ++V +L RG +
Sbjct: 18 HIAVITDQPDIVKCLIYAGANPNLPDR---NGQTPAHLACQRSAVRCLYELTSSSLLDYNIRNFEGLMPLHIAVAKRDKYAIALLVQNGANVDCKDGKSGKTPLHHAIERNDLQIIKTLLDMSADINATDFSGVSPMAMANRRGLANAVRLLGNRGED 172 HSP 3 Score: 50.447 bits (119), Expect = 3.035e-7 Identity = 43/205 (20.98%), Postives = 89/205 (43.41%), Query Frame = 3
Query: 330 VSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGAD 944
+++DI + TPL A ++V+ L+ GA + ++ G H+A + + V L Y + +++ G+ P +AV+K + L++ N ++ CK+G S K+PLH+A E ++I++ L++ A+++ +G +P+ + ++ A+ + LL G D
Sbjct: 4 LTLDIYNNLRQTPLHIAVITDQPDIVKCLIYAGANPNLPDRNGQTPAHLACQRSAVRCL-YELTSSSLLDYNIRNFEGLMPLHIAVAKRDKYAIALLVQ-------------NGANVDCKDG----------------------KSGKTPLHHAIERNDLQIIKTLLDMSADINATDFSGVSPMAMANRRGLANAVRLLGNRGED 172 HSP 4 Score: 49.6766 bits (117), Expect = 5.059e-7 Identity = 46/170 (27.06%), Postives = 76/170 (44.71%), Query Frame = 3
Query: 555 YNGM--SPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDK-SPLHYACENGFIKIVELLIEQGANLSKPTG-NGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDI 1052
YN + +P +AV + K LI + + D+ + HLAC+ + L E+ L + + + PLH A + LL++ GAN+ G +G TPLH +++ II L+ ADIN + G +P+ +A L + V LL + D +
Sbjct: 9 YNNLRQTPLHIAVITDQPDIVKCLIYAGANPNLPDRNGQTPAHLACQ---RSAVRCLYELTSSSLLDYNIRNFEGLMPLHIAVAKRDKYAIALLVQNGANVDCKDGKSGKTPLHHAIERNDLQIIKTLLDMSADINATDFSGVSPMAMANRRGLANAVRLLGNRGEDQRV 175
BLAST of Death domain protein vs. Ensembl Nematostella
Match: EDO29974 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T238]) HSP 1 Score: 83.1889 bits (204), Expect = 1.373e-16 Identity = 79/264 (29.92%), Postives = 125/264 (47.35%), Query Frame = 3
Query: 531 HFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKN------AWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACE-NGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQ------KSFADIILLLIKAGADINCQNMQGNTPLHIA----------TLSNLPSMVTLLLDNNA----DMDIINNRE----QTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
H ++ +D +G +P LAV N + + +AL++ ++++ L N + A +AC N + + LIE + L DK +++ L YA N +V+ L+E GA+++ + TPLH +S + L+IK G DI Q+++G PLH A +LS+ S+ +LLL+ A DM + N QTPLH + LL RGA + ID G TP +AAR + S M I+
Sbjct: 31 HDVINSRDRHGRTPLQLAVKWNNLHAVEALVKAGVNLN-LKSHNADEDFFGTALIMACDNKLQ-VVKALIEGKADVNLTDK---QNRTALSYAVSSNTATPMVQSLLEAGAHVNTADSHARTPLHYAVNATTGGFESLTETEDLVIKHGGDIAAQDIKGRIPLHYAFVKLKKHTDASLSDPVSICSLLLEAMAEHGKDMSKLLNTHDKFGQTPLHRAAIRGATICCLNLLQRGARIDAIDNDGNTPFSLAARHGHHSCAMMFIQ 289 HSP 2 Score: 51.6026 bits (122), Expect = 8.230e-7 Identity = 41/166 (24.70%), Postives = 80/166 (48.19%), Query Frame = 3
Query: 714 LLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNG----FTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPS-MVTLLLDNNADMDIINNREQTPLHAGVE------QNKCDSVEILLLRGANLSNIDKTGKTPL 1178
LL + ++++ D ++PL A + + VE L++ G NL+ + N F I+ + ++ LI+ AD+N + Q T L A SN + MV LL+ A ++ ++ +TPLH V ++ ++ ++++ G +++ D G+ PL
Sbjct: 23 LLGRLAACHDVINSRDRHGRTPLQLAVKWNNLHAVEALVKAGVNLNLKSHNADEDFFGTALIMACDNKLQVVKALIEGKADVNLTDKQNRTALSYAVSSNTATPMVQSLLEAGAHVNTADSHARTPLHYAVNATTGGFESLTETEDLVIKHGGDIAAQDIKGRIPL 188 HSP 3 Score: 48.9062 bits (115), Expect = 5.433e-6 Identity = 67/263 (25.48%), Postives = 105/263 (39.92%), Query Frame = 3
Query: 348 DKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCD----IVHIAAEGNFVNILEYMFRKHRHFKLDD-QDYNGMSPFLLAVSKNCVLS-AKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEME--VPKELMD--KLDSSDKSPLHYACENGFIKI------------------VELLIEQGANLSKPTGN----GFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNA 1040
D++G TPL A + +L V+ LV+ G ++ ++ + I A N + +++ + L D Q+ +S AVS N ++L+E V+ D + H A N F L E E V K D D + PLHYA F+K+ +E + E G ++SK G TPLH + L L++ GA I+ + GNTP +A S + + NA
Sbjct: 38 DRHGRTPLQLAVKWNNLHAVEALVKAGVNLNLKSHNADEDFFGTALIMACDNKLQVVKALIEGKADVNLTDKQNRTALS---YAVSSNTATPMVQSLLEAGAHVNTADSHARTPLHYAV-NATTGGFESLTETEDLVIKHGGDIAAQDIKGRIPLHYA----FVKLKKHTDASLSDPVSICSLLLEAMAEHGKDMSKLLNTHDKFGQTPLHRAAIRGATICCLNLLQRGARIDAIDNDGNTPFSLAARHGHHSCAMMFIQMNA 292 HSP 4 Score: 48.521 bits (114), Expect = 8.130e-6 Identity = 88/344 (25.58%), Postives = 131/344 (38.08%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGA-----VIS--------KRNKQGCDIVHIAAE------------GNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHL-------ACKNGH-ENIFNLLI---EMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIE---QGANLSKPTGNGFTPLHIV--TQKSFA---DIILLLIKAGA---DINCQ-------NMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILL 1127
+T LH AA +G L+ G +D D G TP AA GH ++ A VI+ K KQ + + E F +++E+ ++ H LD + M + A L+ K S + +T+ N L A G EN + I ++E LDS PLHYA NG + ELL+ N++ P NG TPL T + A ++I +L+ A DI Q + TPL A L ++V LDNNA ++ +T L + N+ D ++LL
Sbjct: 236 QTPLHRAAIRGATICCLNLLQRG-ARIDAIDNDGNTPFSLAARHGHHSCAMMFIQMNAPARCDVITPVTPEQRNKYEKQRRSAMWVWQETVNLHPPTPVIVSAFRSVVEHGWQGVAHLMLDTAGLDFMVALRAVFEARKMDLAWTLLRKQRKDSSIQETDSNGLSLLHLLAEFATTFGDVENKVTIAILEYQLEERGVSPSALDSRGALPLHYAAINGNKGLCELLLRYNPSTLNVADP--NGMTPLACAFETTSNLATRFELIKMLVSAKPRTLDICYQIGKDDDPDHDSTTPLIQAALHGNENIVKTFLDNNASVNFPKANGRTALMEVIRANEEDMAKVLL 576
BLAST of Death domain protein vs. Ensembl Medaka
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:NCBI gene;Acc:101164158]) HSP 1 Score: 243.817 bits (621), Expect = 2.910e-72 Identity = 165/522 (31.61%), Postives = 256/522 (49.04%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYN--------------------------GMSPFLLAVSKNCVLSAKALIEK-DIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKS 1736
DRTALH AA+ EA + L+ + +V VD DKYGMTP+ A++FG LE+++ LV+ GA N+ G +I+H AA N ILEY+ + +LD D G PF LA CV K L+E ++ + +K HLA +NGH LL++ + D+++ ++ L+ A N + V L+E G + + T LH V+++ A ++ LL++ D + QN PLH+A ++ ++ LL ++++ + R QT +H E + + VE+LL G +L+ DK GKT L +AAR + + +VDMIIKAER Y+ H E +++ + P + K ++ + + W++A L+ +WK+LA +W F E + AIE Q T +SYK HG+R+L IW HG E +Q P + LY+ L++ G RK ADKIR E + G KS
Sbjct: 94 DRTALHFAAAGRKSEAVQFLL-QRRVKVDQKDKYGMTPIHLASWFGSLEILKLLVQAGAEQKVENEDGLNIMHCAAINNHTEILEYIVNGLQMKELDKDDQVSVEHSAFMNVNTTCSADPASGYILQLGRRPFALAAEHGCVEMLKILMEPYNMATMKPNKKGDTPLHLAARNGHLEAVQLLLQ---SFDTRDEVNMDGETALYQAAHNNQEQCVLALLEGGCDPNIITAAKCNALHPVSERGEASLVQLLLQYKTDADVQNQHLEAPLHLAVRNSRIPVIHSLLAAGCNINLTDKRSQTAMHFAAELAQTELVEMLLKAGVDLTLQDKQGKTALGVAARANKVIIVDMIIKAER-----------------------------------YYAWRKAHPEPNERVCSEYP-LTFKLDHRHETKHLRSMAWRLAHQLLKAGDWKRLAEHWNFTKEQVSAIEEQWTGQHSYKEHGHRMLLIWLHGEELAQRNPAKELYQDLITSGNRKAADKIREEAEHRGRKS 575
BLAST of Death domain protein vs. Ensembl Medaka
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:NCBI gene;Acc:101164158]) HSP 1 Score: 243.047 bits (619), Expect = 4.095e-72 Identity = 157/482 (32.57%), Postives = 247/482 (51.24%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEK-DIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLA 1694
DRTALH AA+ EA + L+ + +V VD DKYGMTP+ A++FG LE+++ LV+ GA N+ G +I+H AA N ILEY+ + +LD D G PF LA CV K L+E ++ + +K HLA +NGH LL++ + D+++ ++ L+ A N + V L+E G + + T LH V+++ A ++ LL++ D + QN PLH+A ++ ++ LL ++++ + R QT +H E + + VE+LL G +L+ DK GKT L +AAR + + +VDMIIKAER Y+ H E +++ + P + K ++ + + W++A L+ +WK+LA +W F E + AIE Q T +SYK HG+R+L IW HG E +Q P + LY+ L++ G RK A
Sbjct: 94 DRTALHFAAAGRKSEAVQFLL-QRRVKVDQKDKYGMTPIHLASWFGSLEILKLLVQAGAEQKVENEDGLNIMHCAAINNHTEILEYIVNGLQMKELDKDDQLGRRPFALAAEHGCVEMLKILMEPYNMATMKPNKKGDTPLHLAARNGHLEAVQLLLQ---SFDTRDEVNMDGETALYQAAHNNQEQCVLALLEGGCDPNIITAAKCNALHPVSERGEASLVQLLLQYKTDADVQNQHLEAPLHLAVRNSRIPVIHSLLAAGCNINLTDKRSQTAMHFAAELAQTELVEMLLKAGVDLTLQDKQGKTALGVAARANKVIIVDMIIKAER-----------------------------------YYAWRKAHPEPNERVCSEYP-LTFKLDHRHETKHLRSMAWRLAHQLLKAGDWKRLAEHWNFTKEQVSAIEEQWTGQHSYKEHGHRMLLIWLHGEELAQRNPAKELYQDLITSGNRKAA 535
BLAST of Death domain protein vs. Ensembl Medaka
Match: ankdd1b (ankyrin repeat and death domain containing 1B [Source:NCBI gene;Acc:101164158]) HSP 1 Score: 229.18 bits (583), Expect = 1.144e-66 Identity = 157/508 (30.91%), Postives = 247/508 (48.62%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYN--------------------------GMSPFLLAVSKNCVLSAKALIEK-DIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVE-SQDTPVRGLYEALVSIGRRKLA 1694
DRTALH AA+ EA + L+ + +V VD DKYGMTP+ A++FG LE+++ LV+ GA N+ G +I+H AA N ILEY+ + +LD D G PF LA CV K L+E ++ + +K HLA +NGH LL++ + D+++ ++ L+ A N + V L+E G + + T LH V+++ A ++ LL++ D + QN PLH+A ++ ++ LL ++++ + R QT +H E + + VE+LL G +L+ DK GKT L +AAR + + +VDMIIKAER Y+ H E +++ + P + K ++ + + W++A L+ +WK+LA +W F E + AIE Q T +SYK HG+R+L IW HG E +Q P + LY+ L++ G RK A
Sbjct: 94 DRTALHFAAAGRKSEAVQFLL-QRRVKVDQKDKYGMTPIHLASWFGSLEILKLLVQAGAEQKVENEDGLNIMHCAAINNHTEILEYIVNGLQMKELDKDDQVSVEHSAFMNVNTTCSADPASGYILQLGRRPFALAAEHGCVEMLKILMEPYNMATMKPNKKGDTPLHLAARNGHLEAVQLLLQ---SFDTRDEVNMDGETALYQAAHNNQEQCVLALLEGGCDPNIITAAKCNALHPVSERGEASLVQLLLQYKTDADVQNQHLEAPLHLAVRNSRIPVIHSLLAAGCNINLTDKRSQTAMHFAAELAQTELVEMLLKAGVDLTLQDKQGKTALGVAARANKVIIVDMIIKAER-----------------------------------YYAWRKAHPEPNERVCSEYP-LTFKLDHRHETKHLRSMAWRLAHQLLKAGDWKRLAEHWNFTKEQVSAIEEQWTGQHSYKEHGHRMLLIWLHGEELAQRNPAKELYQDLITSGNRKAA 561
BLAST of Death domain protein vs. Ensembl Medaka
Match: ENSORLT00000039458.1 (ankyrin 2 [Source:NCBI gene;Acc:101161458]) HSP 1 Score: 148.673 bits (374), Expect = 7.208e-37 Identity = 95/323 (29.41%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+AA GH+ +L+ + S D+ + G T L AA G EVV+ L+ GA++ R ++ +HIA+ I++ + + H D NG +P ++ + + +A L+E S K H+ K G ++ LL++ + P D + +PLH A K+ LL+++GA+ NG+TPLHI +K+ DI +L++ GA+ N QG TPLH+A+ M LL+ A +++ T LH ++++ EIL+ GANL + K G TPL++A MV +++
Sbjct: 426 TPIHVAAFMGHLNIV-LLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHP--DAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQRQAPP---DSAGKNGLTPLHVAAHYDNQKVALLLLDKGASPHTTAKNGYTPLHIAAKKNQMDIATVLLQYGAETNALTKQGVTPLHLASQEGHADMAALLMSKGAQINVPTKSGLTALHLAAQEDRVAVAEILVRNGANLDHQTKLGYTPLIVACHYGNAKMVSFLLQ 742 HSP 2 Score: 145.591 bits (366), Expect = 6.607e-36 Identity = 94/324 (29.01%), Postives = 163/324 (50.31%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
T LH+AA G++ +L+ G +VD + G+TPL A+ G+ +V+ L+++G+ I + + G +H AA +E + K L + NG+SP +A + V K L++ V + A H+A GH + LL++ + + +PLH AC+ +K++ELL++ GA++ T +G TP+H+ +I+LLL++ GA + N++G T LH+A + +V LL N A +D +QTPLH K + V++LL A+ G TPL ++AR + ++++A
Sbjct: 228 TPLHIAAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKG--APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRVKVMELLVKYGASIQAVTESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQLETASVLLEA 545 HSP 3 Score: 135.191 bits (339), Expect = 1.436e-32 Identity = 99/358 (27.65%), Postives = 166/358 (46.37%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A D+T LH+A+ G E ++L+ + D G TPL +A G LE L+E GA S K+G +H+ ++ +++ + + + R D NG++P +A + A L++K K H+A K +I +L++ + K +PLH A + G + LL+ +GA ++ PT +G T LH+ Q+ + +L++ GA+++ Q G TPL +A MV+ LL N A ++ TPLH +Q + +LL GA + + G T L +A R YIS+VD +
Sbjct: 456 RGETSLHMAARAGQAEVVRCLLRNGAMVDARARE-DQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQ--RQAPPDSAGKNGLTPLHVAAHYDNQKVALLLLDKGASPHTTAKNGYTPLHIAAKKNQMDIATVLLQYGAETNALTK---QGVTPLHLASQEGHADMAALLMSKGAQINVPTKSGLTALHLAAQEDRVAVAEILVRNGANLDHQTKLGYTPLIVACHYGNAKMVSFLLQNGASVNAKTKNGYTPLHQAAQQGNTHIINVLLQHGAKPNAVTVNGNTALGIARRLGYISVVDTL 806 HSP 4 Score: 133.265 bits (334), Expect = 7.527e-32 Identity = 90/323 (27.86%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T+ AA G+I+ + +G V + ++ G+ L AA GH+++VQ L+++GA + K+G +HI++ +++ + + R ++ Q NG +P +A +N + + L+E + S + +A + GH + ++L+E + ++ +L + LH A K LL++ N + +GFTPLHI ++ LL+ GA ++ G TPLH+A+ +MV LLLD + +D TPLH SVE+LL +GA L K G +PL MAA+G ++ V +++
Sbjct: 34 TSFLRAARAGNIDKV-LEYLKGGVDISTCNQNGLNALHLAAKEGHMDLVQELLDRGAPVDSSTKKGNTALHISSLAGQAEVVKTLVK--RGADINAQSQNGFTPLYMAAQENHLDVVRYLLENGGNQSTATEDGFTPLAIALQQGHNQVVSILLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 346 HSP 5 Score: 132.88 bits (333), Expect = 8.380e-32 Identity = 89/325 (27.38%), Postives = 162/325 (49.85%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T LH+A+ +G+ R+L+ G +D + G+TPL AA GH V+ L+EKGA + R K G +H+AA+G+ V ++++ +H+ +DD + ++ +A K L++K + + H+ACK + LL++ + + S +P+H A G + IV LL++ GA+ G T LH+ + A+++ L++ GA ++ + + TPLHIA+ +V LLL + A D TPLH + + ++ +LL GA+ S K G TPL + ++ + + ++++ +
Sbjct: 261 TPLHVASKRGNTNMVRLLLDRGS-QIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLL-QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRVKVMELLVKYGAS---IQAVTESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQRQ 579 HSP 6 Score: 118.242 bits (295), Expect = 4.261e-27 Identity = 85/321 (26.48%), Postives = 158/321 (49.22%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
ALH+AA +GH++ + L+ G VD K G T L ++ G EVV+ LV++GA I+ +++ G +++AA+ N ++++ Y+ + +D G +P +A+ + L+E D K A H+A + LL++ + ++ K S +PLH A G + + LL+ +GA + NG TPLH+ +++ +++ LL+ G+ I+ + G TPLH A S + V +LL+ A + +PLH + + + V+ LL A + ++ T L +AA + + +++
Sbjct: 68 ALHLAAKEGHMDLVQELLDRG-APVDSSTKKGNTALHISSLAGQAEVVKTLVKRGADINAQSQNGFTPLYMAAQENHLDVVRYLLENGGNQSTATED--GFTPLAIALQQGHNQVVSILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK---SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 378
BLAST of Death domain protein vs. Ensembl Medaka
Match: ENSORLT00000031565.1 (ankyrin 2 [Source:NCBI gene;Acc:101161458]) HSP 1 Score: 148.673 bits (374), Expect = 7.227e-37 Identity = 95/323 (29.41%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T +H+AA GH+ +L+ + S D+ + G T L AA G EVV+ L+ GA++ R ++ +HIA+ I++ + + H D NG +P ++ + + +A L+E S K H+ K G ++ LL++ + P D + +PLH A K+ LL+++GA+ NG+TPLHI +K+ DI +L++ GA+ N QG TPLH+A+ M LL+ A +++ T LH ++++ EIL+ GANL + K G TPL++A MV +++
Sbjct: 441 TPIHVAAFMGHLNIV-LLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHP--DAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQRQAPP---DSAGKNGLTPLHVAAHYDNQKVALLLLDKGASPHTTAKNGYTPLHIAAKKNQMDIATVLLQYGAETNALTKQGVTPLHLASQEGHADMAALLMSKGAQINVPTKSGLTALHLAAQEDRVAVAEILVRNGANLDHQTKLGYTPLIVACHYGNAKMVSFLLQ 757 HSP 2 Score: 145.591 bits (366), Expect = 6.868e-36 Identity = 94/324 (29.01%), Postives = 163/324 (50.31%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
T LH+AA G++ +L+ G +VD + G+TPL A+ G+ +V+ L+++G+ I + + G +H AA +E + K L + NG+SP +A + V K L++ V + A H+A GH + LL++ + + +PLH AC+ +K++ELL++ GA++ T +G TP+H+ +I+LLL++ GA + N++G T LH+A + +V LL N A +D +QTPLH K + V++LL A+ G TPL ++AR + ++++A
Sbjct: 243 TPLHIAAHYGNVNVATLLLNRG-AAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKG--APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRVKVMELLVKYGASIQAVTESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQLETASVLLEA 560 HSP 3 Score: 135.191 bits (339), Expect = 1.493e-32 Identity = 99/358 (27.65%), Postives = 166/358 (46.37%), Query Frame = 3
Query: 150 KNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMI 1223
+ E LH AAR ++R +++ A D+T LH+A+ G E ++L+ + D G TPL +A G LE L+E GA S K+G +H+ ++ +++ + + + R D NG++P +A + A L++K K H+A K +I +L++ + K +PLH A + G + LL+ +GA ++ PT +G T LH+ Q+ + +L++ GA+++ Q G TPL +A MV+ LL N A ++ TPLH +Q + +LL GA + + G T L +A R YIS+VD +
Sbjct: 471 RGETSLHMAARAGQAEVVRCLLRNGAMVDARARE-DQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQ--RQAPPDSAGKNGLTPLHVAAHYDNQKVALLLLDKGASPHTTAKNGYTPLHIAAKKNQMDIATVLLQYGAETNALTK---QGVTPLHLASQEGHADMAALLMSKGAQINVPTKSGLTALHLAAQEDRVAVAEILVRNGANLDHQTKLGYTPLIVACHYGNAKMVSFLLQNGASVNAKTKNGYTPLHQAAQQGNTHIINVLLQHGAKPNAVTVNGNTALGIARRLGYISVVDTL 821 HSP 4 Score: 132.88 bits (333), Expect = 8.402e-32 Identity = 90/323 (27.86%), Postives = 159/323 (49.23%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
T+ AA G+I+ + +G V + ++ G+ L AA GH+++VQ L+++GA + K+G +HI++ +++ + + R ++ Q NG +P +A +N + + L+E + S + +A + GH + ++L+E + ++ +L + LH A K LL++ N + +GFTPLHI ++ LL+ GA ++ G TPLH+A+ +MV LLLD + +D TPLH SVE+LL +GA L K G +PL MAA+G ++ V +++
Sbjct: 49 TSFLRAARAGNIDKV-LEYLKGGVDISTCNQNGLNALHLAAKEGHMDLVQELLDRGAPVDSSTKKGNTALHISSLAGQAEVVKTLVK--RGADINAQSQNGFTPLYMAAQENHLDVVRYLLENGGNQSTATEDGFTPLAIALQQGHNQVVSILLENDTKGKV--RLPA-----LHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 361 HSP 5 Score: 132.88 bits (333), Expect = 8.477e-32 Identity = 89/325 (27.38%), Postives = 162/325 (49.85%), Query Frame = 3
Query: 261 TALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAE 1235
T LH+A+ +G+ R+L+ G +D + G+TPL AA GH V+ L+EKGA + R K G +H+AA+G+ V ++++ +H+ +DD + ++ +A K L++K + + H+ACK + LL++ + + S +P+H A G + IV LL++ GA+ G T LH+ + A+++ L++ GA ++ + + TPLHIA+ +V LLL + A D TPLH + + ++ +LL GA+ S K G TPL + ++ + + ++++ +
Sbjct: 276 TPLHVASKRGNTNMVRLLLDRGS-QIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLL-QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRVKVMELLVKYGAS---IQAVTESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETSLHMAARAGQAEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQLETASVLLEAGASHSLATKKGFTPLHVVSKYGSLDVAKLLLQRQ 594 HSP 6 Score: 118.242 bits (295), Expect = 4.159e-27 Identity = 85/321 (26.48%), Postives = 158/321 (49.22%), Query Frame = 3
Query: 264 ALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMII 1226
ALH+AA +GH++ + L+ G VD K G T L ++ G EVV+ LV++GA I+ +++ G +++AA+ N ++++ Y+ + +D G +P +A+ + L+E D K A H+A + LL++ + ++ K S +PLH A G + + LL+ +GA + NG TPLH+ +++ +++ LL+ G+ I+ + G TPLH A S + V +LL+ A + +PLH + + + V+ LL A + ++ T L +AA + + +++
Sbjct: 83 ALHLAAKEGHMDLVQELLDRG-APVDSSTKKGNTALHISSLAGQAEVVKTLVKRGADINAQSQNGFTPLYMAAQENHLDVVRYLLENGGNQSTATED--GFTPLAIALQQGHNQVVSILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK---SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHEASVEVLLEKGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 393
BLAST of Death domain protein vs. Planmine SMEST
Match: SMESG000003436.1 (SMESG000003436.1) HSP 1 Score: 1103.2 bits (2852), Expect = 0.000e+0 Identity = 565/567 (99.65%), Postives = 566/567 (99.82%), Query Frame = 3
Query: 63 MAKPVLDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH 1763
MAKPVLDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRKIIKKNAANLNCKNNLDRTALHMAASQGHIEATRILI EGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELM+KLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNQRKKELQEQEEERLANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH
Sbjct: 1 MAKPVLDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRKIIKKNAANLNCKNNLDRTALHMAASQGHIEATRILIVEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMNKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNQRKKELQEQEEERLANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH 567
BLAST of Death domain protein vs. Planmine SMEST
Match: SMESG000003436.1 (SMESG000003436.1) HSP 1 Score: 1093.95 bits (2828), Expect = 0.000e+0 Identity = 565/583 (96.91%), Postives = 566/583 (97.08%), Query Frame = 3
Query: 63 MAKPVLDS----------------GPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRXXXXXXXXXXXXXXXXDRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNXXXXXXXXXXXXXXANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH 1763
MAKPVLDS GPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRKIIKKNAANLNCKNNLDRTALHMAASQGHIEATRILI EGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELM+KLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNQRKKELQEQEEERLANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH
Sbjct: 1 MAKPVLDSKKDSPGTKMRSNNVYVGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRKIIKKNAANLNCKNNLDRTALHMAASQGHIEATRILIVEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMNKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKAERFNQRKKELQEQEEERLANQNKPNGDFLVNAFQPSDYFNVYNIHLEESKQAVFDDPDYSLKEFNQPYAEEFKLYLWKIAFNNLRFDEWKKLAHYWGFKPEHILAIEYQQTKDNSYKYHGYRVLCIWFHGVESQDTPVRGLYEALVSIGRRKLADKIRRELDSEGGKSKGNSSCIIH 583
BLAST of Death domain protein vs. Planmine SMEST
Match: SMESG000017277.1 (SMESG000017277.1) HSP 1 Score: 149.828 bits (377), Expect = 1.129e-37 Identity = 91/325 (28.00%), Postives = 160/325 (49.23%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A ++ + ++ D+ +N P LA + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD + P+H+AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N D++ +++R Q P+H +Q ++V++L+ ++ +D+ + P+ +A V ++I+
Sbjct: 234 NRRPIHLACDQGHSEAVKLLI-EHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDE-WN-RRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENKCD---IEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIE 552 HSP 2 Score: 142.51 bits (358), Expect = 2.818e-35 Identity = 89/325 (27.38%), Postives = 156/325 (48.00%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ D + P+ A GH E V+ L+E I +KQ +H+A ++ + +H+ ++ D P LA + + K LIE D+ LD+ N+ HLAC GH LLIE + E +DK ++ P+H AC+ G V+LLIE ++ P+H + ++ + LLI+ DI + P+H+A V LL++N D++ ++ R Q P+H +Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 201 NRRPIHIACYQGHSEAVKLLI-ENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLI-EHK-CDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKW---NQRPIHLACDQGHSGAVKLLIENKCDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIE 519 HSP 3 Score: 137.887 bits (346), Expect = 1.122e-33 Identity = 83/321 (25.86%), Postives = 154/321 (47.98%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+H+A QGH EA ++LI E K ++ DK P+ A GH E V+ L+E I +K +H++ ++ + ++ D P L+ + + K LIE + D+ LD N+ H+AC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL++N D+++++ + P+H +Q ++V++L+ ++ +DK + P+ +A + V ++I+
Sbjct: 73 IHLACYQGHSEAVKLLI-ENKCDIEALDKQKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENK--CDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCD---IEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIE 387 HSP 4 Score: 136.732 bits (343), Expect = 2.664e-33 Identity = 86/324 (26.54%), Postives = 155/324 (47.84%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
R +H A GH E ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A + ++ + +H+ ++ D P L+ + + K LIE D+ LDK N HL+C GH LLIE ++ LD ++ P+H AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL+++ D++ ++ ++Q P+H Q ++V++L+ ++ +D+ + P+ +A + V ++I+
Sbjct: 37 RRPIHHACITGHAEIVKLLI-EHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDKQKQRPIHLACDQGHSEAVKLLI-EHK-CDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCD---IEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIE 354 HSP 5 Score: 135.576 bits (340), Expect = 6.321e-33 Identity = 83/321 (25.86%), Postives = 152/321 (47.35%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+H+A QGH EA ++LI E K +++ D++ P+ A GH E V+ L+E I +K +H+A + ++ + ++ D P A + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N ++ ++ Q P+H Q ++V++L+ ++ +DK + P+ +A + ++I+
Sbjct: 304 IHLACYQGHSEAVKLLI-ENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENK--CDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCD---IEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIENKCYIEALDKWNQRPIHLACIQGHSEAVKLLIENKCDIEALDKRNQRPIHLACYYGHSKAFKLLIE 618 HSP 6 Score: 130.183 bits (326), Expect = 3.222e-31 Identity = 83/326 (25.46%), Postives = 150/326 (46.01%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
+R +H+A QGH EA ++LI E K ++ DK+ P+ A GH V+ L+E I ++Q +H A ++ + ++ D P LA + + K LIE D+ LD+ N+ HLAC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ ++ + LLI+ I + P+H+A + V LL++N D++ ++ R Q P+H + ++L+ + D++G +P+ A + ++ ++ +A
Sbjct: 333 NRRPIHLACDQGHSEAVKLLI-ENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENKCDIEALDEQKRRPIHHACIQGHSEAVKLLIENK--CDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCD---IEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIENKCYIEALDKWNQRPIHLACIQGHSEAVKLLIENKCDIEALDKRNQRPIHLACYYGHSKAFKLLIEHKCEIDARDESGNSPMEFAMKFGNTEIIKILNEA 652 HSP 7 Score: 103.99 bits (258), Expect = 6.902e-23 Identity = 68/253 (26.88%), Postives = 123/253 (48.62%), Query Frame = 3
Query: 492 FVNILEY----MFRKHRHFK---LDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
F+N ++ +FR R+FK L+ +D + P A K LIE D+ LDK N HLAC GH LLIE + E +DK + P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H++ + V LL+++N D++ ++ R + P+H Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 8 FINAIKSGSAELFR--RYFKEEFLERKDSDLRRPIHHACITGHAEIVKLLIEHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDK---QKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIE 255
BLAST of Death domain protein vs. Planmine SMEST
Match: SMESG000017277.1 (SMESG000017277.1) HSP 1 Score: 149.828 bits (377), Expect = 1.195e-37 Identity = 91/325 (28.00%), Postives = 160/325 (49.23%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A ++ + ++ D+ +N P LA + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD + P+H+AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N D++ +++R Q P+H +Q ++V++L+ ++ +D+ + P+ +A V ++I+
Sbjct: 234 NRRPIHLACDQGHSEAVKLLI-EHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDE-WN-RRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENKCD---IEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIE 552 HSP 2 Score: 142.51 bits (358), Expect = 3.065e-35 Identity = 89/325 (27.38%), Postives = 156/325 (48.00%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ D + P+ A GH E V+ L+E I +KQ +H+A ++ + +H+ ++ D P LA + + K LIE D+ LD+ N+ HLAC GH LLIE + E +DK ++ P+H AC+ G V+LLIE ++ P+H + ++ + LLI+ DI + P+H+A V LL++N D++ ++ R Q P+H +Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 201 NRRPIHIACYQGHSEAVKLLI-ENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLI-EHK-CDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKW---NQRPIHLACDQGHSGAVKLLIENKCDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIE 519 HSP 3 Score: 137.502 bits (345), Expect = 1.259e-33 Identity = 83/321 (25.86%), Postives = 154/321 (47.98%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+H+A QGH EA ++LI E K ++ DK P+ A GH E V+ L+E I +K +H++ ++ + ++ D P L+ + + K LIE + D+ LD N+ H+AC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL++N D+++++ + P+H +Q ++V++L+ ++ +DK + P+ +A + V ++I+
Sbjct: 73 IHLACYQGHSEAVKLLI-ENKCDIEALDKQKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENK--CDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCD---IEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIE 387 HSP 4 Score: 136.346 bits (342), Expect = 2.992e-33 Identity = 86/324 (26.54%), Postives = 155/324 (47.84%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
R +H A GH E ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A + ++ + +H+ ++ D P L+ + + K LIE D+ LDK N HL+C GH LLIE ++ LD ++ P+H AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL+++ D++ ++ ++Q P+H Q ++V++L+ ++ +D+ + P+ +A + V ++I+
Sbjct: 37 RRPIHHACITGHAEIVKLLI-EHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDKQKQRPIHLACDQGHSEAVKLLI-EHK-CDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCD---IEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIE 354 HSP 5 Score: 133.265 bits (334), Expect = 2.688e-32 Identity = 82/322 (25.47%), Postives = 151/322 (46.89%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
+H+A QGH EA ++LI E K +++ D++ P+ A GH E V+ L+E I +K +H+A + ++ + ++ D P A + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N ++ ++ R Q P+H + ++L+ + D++G +P+ A + ++ ++ +A
Sbjct: 304 IHLACYQGHSEAVKLLI-ENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENK--CDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCD---IEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIENKCYIEALDKRNQRPIHLACYYGHSKAFKLLIEHKCEIDARDESGNSPMEFAMKFGNTEIIKILNEA 619 HSP 6 Score: 103.99 bits (258), Expect = 6.926e-23 Identity = 68/253 (26.88%), Postives = 123/253 (48.62%), Query Frame = 3
Query: 492 FVNILEY----MFRKHRHFK---LDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
F+N ++ +FR R+FK L+ +D + P A K LIE D+ LDK N HLAC GH LLIE + E +DK + P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H++ + V LL+++N D++ ++ R + P+H Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 8 FINAIKSGSAELFR--RYFKEEFLERKDSDLRRPIHHACITGHAEIVKLLIEHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDK---QKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIE 255
BLAST of Death domain protein vs. Planmine SMEST
Match: SMESG000017277.1 (SMESG000017277.1) HSP 1 Score: 149.443 bits (376), Expect = 1.774e-37 Identity = 91/325 (28.00%), Postives = 160/325 (49.23%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A ++ + ++ D+ +N P LA + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD + P+H+AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N D++ +++R Q P+H +Q ++V++L+ ++ +D+ + P+ +A V ++I+
Sbjct: 234 NRRPIHLACDQGHSEAVKLLI-EHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDE-WN-RRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENKCD---IEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIE 552 HSP 2 Score: 142.124 bits (357), Expect = 4.574e-35 Identity = 89/325 (27.38%), Postives = 156/325 (48.00%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+R +H+A QGH EA ++LI E K ++ D + P+ A GH E V+ L+E I +KQ +H+A ++ + +H+ ++ D P LA + + K LIE D+ LD+ N+ HLAC GH LLIE + E +DK ++ P+H AC+ G V+LLIE ++ P+H + ++ + LLI+ DI + P+H+A V LL++N D++ ++ R Q P+H +Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 201 NRRPIHIACYQGHSEAVKLLI-ENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLI-EHK-CDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKW---NQRPIHLACDQGHSGAVKLLIENKCDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIE 519 HSP 3 Score: 137.117 bits (344), Expect = 1.826e-33 Identity = 83/321 (25.86%), Postives = 154/321 (47.98%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+H+A QGH EA ++LI E K ++ DK P+ A GH E V+ L+E I +K +H++ ++ + ++ D P L+ + + K LIE + D+ LD N+ H+AC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL++N D+++++ + P+H +Q ++V++L+ ++ +DK + P+ +A + V ++I+
Sbjct: 73 IHLACYQGHSEAVKLLI-ENKCDIEALDKQKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENK--CDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCD---IEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIE 387 HSP 4 Score: 135.961 bits (341), Expect = 4.369e-33 Identity = 86/324 (26.54%), Postives = 155/324 (47.84%), Query Frame = 3
Query: 258 RTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
R +H A GH E ++LI E K ++ DK P+ A Y GH E V+ L+E I +KQ +H+A + ++ + +H+ ++ D P L+ + + K LIE D+ LDK N HL+C GH LLIE ++ LD ++ P+H AC G + V+LLIE ++ P+H+ + ++ + LLI+ DI + Q P+H+A V LL+++ D++ ++ ++Q P+H Q ++V++L+ ++ +D+ + P+ +A + V ++I+
Sbjct: 37 RRPIHHACITGHAEIVKLLI-EHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDKQKQRPIHLACDQGHSEAVKLLI-EHK-CDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCD---IEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIEHKCDIEALDKQKQRPIHLACYQGHSEAVKLLIENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIE 354 HSP 5 Score: 134.806 bits (338), Expect = 9.549e-33 Identity = 83/321 (25.86%), Postives = 152/321 (47.35%), Query Frame = 3
Query: 267 LHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+H+A QGH EA ++LI E K +++ D++ P+ A GH E V+ L+E I +K +H+A + ++ + ++ D P A + + K LIE D+ LDK N+ HLAC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H+A V LL++N ++ ++ Q P+H Q ++V++L+ ++ +DK + P+ +A + ++I+
Sbjct: 304 IHLACYQGHSEAVKLLI-ENKCDIEVLDEWNRRPIHLACDQGHSEAVKLLIENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENK--CDIEALDEQKRRPIHHACIQGHSEAVKLLIENKCDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCD---IEALDERNQRPIHLACDQGHSEAVKLLIENKCDIEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIENKCYIEALDKWNQRPIHLACIQGHSEAVKLLIENKCDIEALDKRNQRPIHLACYYGHSKAFKLLIE 618 HSP 6 Score: 129.798 bits (325), Expect = 4.429e-31 Identity = 83/326 (25.46%), Postives = 150/326 (46.01%), Query Frame = 3
Query: 255 DRTALHMAASQGHIEATRILIFEGKVSVDIPDKYGMTPLLWAAYFGHLEVVQFLVEKGAVISKRNKQGCDIVHIAAEGNFVNILEYMFRKHRHFKLDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIKA 1232
+R +H+A QGH EA ++LI E K ++ DK+ P+ A GH V+ L+E I ++Q +H A ++ + ++ D P LA + + K LIE D+ LD+ N+ HLAC GH LLIE + ++ LD ++ P+H AC+ G + V+LLIE ++ P+H+ ++ + LLI+ I + P+H+A + V LL++N D++ ++ R Q P+H + ++L+ + D++G +P+ A + ++ ++ +A
Sbjct: 333 NRRPIHLACDQGHSEAVKLLI-ENKCDIEALDKWNQRPIHLACDQGHSGAVKLLIENKCDIEALDEQKRRPIHHACIQGHSEAVKLLIENK--CDIEALDKWNQRPIHLACYQGHSEAVKLLIENKCDIEALDERNQRPIHLACDQGHSEAVKLLIENKCD---IEALDDRNQRPIHLACDQGHSEAVKLLIENKCDIEALDERNQRPIHLACYYGRSEAVKLLIENKCYIEALDKWNQRPIHLACIQGHSEAVKLLIENKCDIEALDKRNQRPIHLACYYGHSKAFKLLIEHKCEIDARDESGNSPMEFAMKFGNTEIIKILNEA 652 HSP 7 Score: 103.605 bits (257), Expect = 1.220e-22 Identity = 66/242 (27.27%), Postives = 118/242 (48.76%), Query Frame = 3
Query: 513 MFRKHRHFK---LDDQDYNGMSPFLLAVSKNCVLSAKALIEKDIDVSQLDKTNKNAWHLACKNGHENIFNLLIEMEVPKELMDKLDSSDKSPLHYACENGFIKIVELLIEQGANLSKPTGNGFTPLHIVTQKSFADIILLLIKAGADINCQNMQGNTPLHIATLSNLPSMVTLLLDNNADMDIINNREQTPLHAGVEQNKCDSVEILLLRGANLSNIDKTGKTPLLMAARGSYISMVDMIIK 1229
+FR R+FK L+ +D + P A K LIE D+ LDK N HLAC GH LLIE + E +DK + P+H AC+ G + V+LLIE ++ P+H+ + ++ + LLI+ DI + + P+H++ + V LL+++N D++ ++ R + P+H Q ++V++L+ ++ +D + P+ +A + V ++I+
Sbjct: 19 LFR--RYFKEEFLERKDSDLRRPIHHACITGHAEIVKLLIEHKCDIEALDKDNWRPIHLACYQGHSEAVKLLIENKCDIEALDK---QKQRPIHLACDQGHSEAVKLLIEHKCDIEALDKWNQRPIHLSCIQGHSEAVKLLIENKCDIEALDKRNWRPIHLSCIQGHSEAVKLLIEHNCDIEALDWRNRRPIHIACYQGHSEAVKLLIENKCDIEALDWWNRRPIHLACDQGHSEAVKLLIE 255 The following BLAST results are available for this feature:
BLAST of Death domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Death domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Death domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Death domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Death domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Death domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Death domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Death domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30013128 ID=SMED30013128|Name=Death domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1833bpback to top protein sequence of SMED30013128-orf-1 >SMED30013128-orf-1 ID=SMED30013128-orf-1|Name=SMED30013128-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=568bp MAKPVLDSGPKRKDDDCDMVTSLQASELSKNELCLHEAARQNDEMLLRKIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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