Paired like homeobox 2A

Overview


Name	Paired like homeobox 2A
Smed ID	SMED30013056
Length (bp)	1336

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013056

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X2 cell	SMED30013056	h1SMcG0015394	SmedASXL_013700	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30013056	h1SMcG0015394	dd_Smed_v4_29211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30013056	h1SMcG0015394	dd_Smed_v4_29211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30013056	h1SMcG0015394	dd_Smed_v4_29211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30013056	h1SMcG0015394	dd_Smed_v4_29211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30013056	h1SMcG0015394	dd_Smed_v4_29211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30013056	h1SMcG0015394	Contig54418	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30013056	h1SMcG0015394	Contig54418	newmark_ests	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Human
Match: PHOX2A (paired like homeobox 2A [Source:HGNC Symbol;Acc:HGNC:691])

HSP 1 Score: 135.576 bits (340), Expect = 4.776e-36
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +  P      + ++EKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   75 YKFFPEP------SGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 150

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Human
Match: PHOX2B (paired like homeobox 2B [Source:HGNC Symbol;Acc:HGNC:9143])

HSP 1 Score: 134.806 bits (338), Expect = 1.839e-35
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Human
Match: ARX (aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060])

HSP 1 Score: 122.865 bits (307), Expect = 1.117e-29
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  325 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 389

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Human
Match: ALX3 (ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449])

HSP 1 Score: 111.309 bits (277), Expect = 1.317e-26
Identity = 54/97 (55.67%), Postives = 69/97 (71.13%), Query Frame = 1

Query:  730 SYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK------SKNPSTAA 1002
            S  L  SP   D +     K K+RR RTTF++ QL+ELE+ FQ+THYPD+Y RE++A++ DLTEARVQVWFQNRRAK+RK E+       +NP TAA
Sbjct:  131 SLHLPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAA 227

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Human
Match: DRGX (dorsal root ganglia homeobox [Source:HGNC Symbol;Acc:HGNC:21536])

HSP 1 Score: 108.997 bits (271), Expect = 1.744e-26
Identity = 51/93 (54.84%), Postives = 66/93 (70.97%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESDLN 1065
            +RKQRR RTTFT  QL+ LE  F +THYPD++TREE+AMKI+LTEARVQVWFQNRRAK+RK E+      +    G + P   ++P    ++N
Sbjct:   30 RRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTER----GASDQEPGAKEPMAEVTPPPVRNIN 118

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Match: ceh-17 (C. Elegans Homeobox; CEH-17 [Source:UniProtKB/TrEMBL;Acc:G5EC89])

HSP 1 Score: 130.183 bits (326), Expect = 5.462e-35
Identity = 63/84 (75.00%), Postives = 69/84 (82.14%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESP 1026
            N  E+RKQRRIRTTFTS QLKELERSF ETHYPDIYTREEIAM+IDLTEARVQVWFQNRRAK+RK EK +      + D +E P
Sbjct:  142 NPAERRKQRRIRTTFTSGQLKELERSFCETHYPDIYTREEIAMRIDLTEARVQVWFQNRRAKYRKQEKIRR-----VKDEEEDP 220

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Match: alr-1 (AristaLess (Drosophila homeodomain) Related [Source:UniProtKB/TrEMBL;Acc:Q21836])

HSP 1 Score: 112.079 bits (279), Expect = 2.999e-27
Identity = 53/89 (59.55%), Postives = 66/89 (74.16%), Query Frame = 1

Query:  748 SPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS--KNPSTAAMT 1008
            SP D     + N KRKQRR RTTF++ QL ELE+ F  THYPD++TREE+A ++ LTEARVQVWFQNRRAK+RK E+S   +P  A M+
Sbjct:  101 SPSDGTNSPDDNGKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVWFQNRRAKYRKQERSSTHHPYQAPMS 189

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Match: unc-4 (Homeobox protein unc-4 [Source:UniProtKB/Swiss-Prot;Acc:P29506])

HSP 1 Score: 98.2117 bits (243), Expect = 3.807e-23
Identity = 42/76 (55.26%), Postives = 59/76 (77.63%), Query Frame = 1

Query:  793 KQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKE 1020
            K+RR RT F+  QL+ELE +F+ +HYPD++ RE +AM++DL E+RVQVWFQNRRAK+RK E+++N S+    D  E
Sbjct:   87 KRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQNRNGSSEIKKDDGE 162

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Match: ceh-8 (Homeobox protein ceh-8 [Source:UniProtKB/Swiss-Prot;Acc:Q94398])

HSP 1 Score: 97.8265 bits (242), Expect = 7.954e-23
Identity = 42/63 (66.67%), Postives = 50/63 (79.37%), Query Frame = 1

Query:  790 RKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            +KQRR RTTFT+ QL  LE +F +THYPD+Y RE +A K+ L E RVQVWFQNRRAKFR+ EK
Sbjct:   58 KKQRRNRTTFTTFQLHALEAAFDKTHYPDVYARETLAAKVQLPEVRVQVWFQNRRAKFRRQEK 120

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Match: ceh-10 (Homeobox protein ceh-10 [Source:UniProtKB/Swiss-Prot;Acc:P41935])

HSP 1 Score: 98.9821 bits (245), Expect = 1.147e-22
Identity = 44/70 (62.86%), Postives = 55/70 (78.57%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPST 996
            KRK+RR RT FT  Q+ ELE++FQ++HYPDIY RE +A K +L E R+QVWFQNRRAK+RK EK+   ST
Sbjct:  133 KRKKRRHRTIFTQYQIDELEKAFQDSHYPDIYAREVLAGKTELQEDRIQVWFQNRRAKWRKTEKTWGKST 202

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Match: PHDP (gene:FBgn0025334 transcript:FBtr0072224)

HSP 1 Score: 117.087 bits (292), Expect = 3.440e-30
Identity = 57/92 (61.96%), Postives = 68/92 (73.91%), Query Frame = 1

Query:  760 ADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSK---NPSTAAMTDGKESP 1026
             D   ++ +K KQRRIRTTFTS QL ELE+ F ETHYPDIYTREEIA K+ LTEARVQVWFQNRRAKFRK E+         ++  DG+++P
Sbjct:  100 GDDGLSLTDKSKQRRIRTTFTSNQLNELEKIFLETHYPDIYTREEIASKLHLTEARVQVWFQNRRAKFRKQERHAIYIMKDKSSKLDGRKNP 191

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Match: al (gene:FBgn0000061 transcript:FBtr0078053)

HSP 1 Score: 117.472 bits (293), Expect = 1.076e-28
Identity = 50/64 (78.12%), Postives = 58/64 (90.62%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            KRKQRR RTTFTS QL+ELE++F  THYPD++TREE+AMKI LTEAR+QVWFQNRRAK+RK EK
Sbjct:   82 KRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEK 145

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Match: Pph13 (gene:FBgn0023489 transcript:FBtr0078070)

HSP 1 Score: 116.316 bits (290), Expect = 1.386e-28
Identity = 49/64 (76.56%), Postives = 58/64 (90.62%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            KRKQRR RTTF + QL+ELER+FQ THYPD++ REE+A++IDLTEARVQVWFQNRRAK+RK EK
Sbjct:    7 KRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEK 70

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Match: Drgx (gene:FBgn0085369 transcript:FBtr0302391)

HSP 1 Score: 112.849 bits (281), Expect = 1.792e-26
Identity = 48/67 (71.64%), Postives = 60/67 (89.55%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKN 987
            +RKQRR RTTFT  QL+ELE +F +THYPD++TRE++AMKI+LTEARVQVWFQNRRAK+RK E+ K+
Sbjct:   49 RRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKD 115

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Match: Drgx (gene:FBgn0085369 transcript:FBtr0339572)

HSP 1 Score: 112.849 bits (281), Expect = 1.792e-26
Identity = 48/67 (71.64%), Postives = 60/67 (89.55%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKN 987
            +RKQRR RTTFT  QL+ELE +F +THYPD++TRE++AMKI+LTEARVQVWFQNRRAK+RK E+ K+
Sbjct:   49 RRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKD 115

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
Match: phox2bb (paired like homeobox 2Bb [Source:ZFIN;Acc:ZDB-GENE-050407-3])

HSP 1 Score: 135.961 bits (341), Expect = 2.931e-37
Identity = 68/95 (71.58%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESD 1059
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++   + AA  +G    +G  S  RE D
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNG----TGKKSDSREED 181

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
Match: phox2bb (paired like homeobox 2Bb [Source:ZFIN;Acc:ZDB-GENE-050407-3])

HSP 1 Score: 137.502 bits (345), Expect = 6.829e-37
Identity = 68/95 (71.58%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESD 1059
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++   + AA  +G    +G  S  RE D
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNG----TGKKSDSREED 181

[Close]

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESD 1059
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++   + AA  +G    +G  S  RE D
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNG----TGKKSDSREED 181

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
Match: phox2a (paired like homeobox 2A [Source:ZFIN;Acc:ZDB-GENE-000223-14])

HSP 1 Score: 135.961 bits (341), Expect = 2.414e-36
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +S        + +NEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   77 YKFFSD------ASGLNEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 152

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
Match: arxb (aristaless related homeobox b [Source:ZFIN;Acc:ZDB-GENE-121109-2])

HSP 1 Score: 120.168 bits (300), Expect = 1.141e-29
Identity = 52/64 (81.25%), Postives = 61/64 (95.31%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK
Sbjct:  159 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 222

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
Match: phox2a (paired like homeobox 2A [Source:NCBI gene;Acc:100486496])

HSP 1 Score: 139.428 bits (350), Expect = 1.599e-37
Identity = 64/83 (77.11%), Postives = 71/83 (85.54%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            YK +S P      + INEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++
Sbjct:   77 YKFFSDP------SGINEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERA 153

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
Match: polr2a (polymerase (RNA) II (DNA directed) polypeptide A, 220kDa [Source:Xenbase;Acc:XB-GENE-6257521])

HSP 1 Score: 137.502 bits (345), Expect = 1.158e-36
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
Match: ARX (aristaless related homeobox [Source:NCBI gene;Acc:100486727])

HSP 1 Score: 122.479 bits (306), Expect = 1.158e-29
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  298 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 362

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
Match: vill (villin like [Source:Xenbase;Acc:XB-GENE-945607])

HSP 1 Score: 116.316 bits (290), Expect = 4.131e-29
Identity = 72/172 (41.86%), Postives = 99/172 (57.56%), Query Frame = 1

Query:  745 SSPVDADIVTNINE---KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK-------SKNPSTAAMTDGKE-SPSGSISPKRESDLNLNSLNINKASEERNMFSQSDKFNSLLVSSSI--ASHADYMSKNHFLMGTSLSNL 1221
            S P  A   +  ++   +RKQRR RTTFT  QL+ LE  F +THYPD++TREE+AMKI+LTEARVQVWFQNRRAK+RK E+       +K  +    T G+  SPS ++ P R     L +      S +R + S +  F S L  + +  AS+A  +S    L G+ L + 
Sbjct:   14 SPPFGAHAASEFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGSCEQEGAKESAPEVTTAGRNLSPSSTVEPVRGKKETLEAQQ-RCLSHDRAVGSATSFFPSCLPGALLNTASYAQALSHVASLKGSPLCSC 184

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Mouse
Match: Phox2a (paired-like homeobox 2a [Source:MGI Symbol;Acc:MGI:106633])

HSP 1 Score: 136.732 bits (343), Expect = 1.405e-36
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +  P      + ++EKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   75 YKFFPEP------SGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 150

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Mouse
Match: Phox2b (paired-like homeobox 2b [Source:MGI Symbol;Acc:MGI:1100882])

HSP 1 Score: 134.806 bits (338), Expect = 1.263e-35
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Mouse
Match: Arx (aristaless related homeobox [Source:MGI Symbol;Acc:MGI:1097716])

HSP 1 Score: 122.094 bits (305), Expect = 1.600e-29
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  327 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 391

[Close]

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  327 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 391

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Mouse
Match: Prrxl1 (paired related homeobox protein-like 1 [Source:MGI Symbol;Acc:MGI:2148204])

HSP 1 Score: 107.842 bits (268), Expect = 4.100e-27
Identity = 51/93 (54.84%), Postives = 66/93 (70.97%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESDLN 1065
            +RKQRR RTTFT  QL+ LE  F +THYPD++TREE+AMKI+LTEARVQVWFQNRRAK+RK E+      +    G + P   ++P    ++N
Sbjct:   30 RRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTER----GASDQEPGAKEPMAEVTPPPVRNIN 118

[Close]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Match: sp|Q62066|PHX2A_MOUSE (Paired mesoderm homeobox protein 2A OS=Mus musculus OX=10090 GN=Phox2a PE=2 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 9.825e-36
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +  P      + ++EKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   75 YKFFPEP------SGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 150

[Close]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Match: sp|Q62782|PHX2A_RAT (Paired mesoderm homeobox protein 2A OS=Rattus norvegicus OX=10116 GN=Phox2a PE=2 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 1.616e-35
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +  P      + ++EKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   75 YKFFPEP------SGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 150

[Close]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Match: sp|O14813|PHX2A_HUMAN (Paired mesoderm homeobox protein 2A OS=Homo sapiens OX=9606 GN=PHOX2A PE=1 SV=2)

HSP 1 Score: 135.576 bits (340), Expect = 2.294e-35
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            YK +  P      + ++EKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   75 YKFFPEP------SGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 150

[Close]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Match: sp|O35690|PHX2B_MOUSE (Paired mesoderm homeobox protein 2B OS=Mus musculus OX=10090 GN=Phox2b PE=1 SV=1)

HSP 1 Score: 134.806 bits (338), Expect = 8.833e-35
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Match: sp|Q99453|PHX2B_HUMAN (Paired mesoderm homeobox protein 2B OS=Homo sapiens OX=9606 GN=PHOX2B PE=1 SV=2)

HSP 1 Score: 134.806 bits (338), Expect = 8.833e-35
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. TrEMBL
Match: A0A336MU29 (CSON006710 protein (Fragment) OS=Culicoides sonorensis OX=179676 GN=CSON006710 PE=4 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 4.921e-37
Identity = 77/110 (70.00%), Postives = 87/110 (79.09%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK------SKNPSTA--AMTDGKESPSGSI 1038
            YK+YSS    D V  ++EKRKQRRIRTTFTSAQLKELER+FQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRK E+      + N ST+   M +G+   SGS+
Sbjct:    4 YKVYSS---HDSV--LSEKRKQRRIRTTFTSAQLKELERAFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKQERLAQQKVTNNNSTSSDGMKNGENHKSGSM 108

[Close]

BLAST of Paired like homeobox 2A vs. TrEMBL
Match: U3JUS3 (Paired like homeobox 2A OS=Ficedula albicollis OX=59894 GN=PHOX2A PE=4 SV=1)

HSP 1 Score: 144.05 bits (362), Expect = 6.230e-37
Identity = 70/99 (70.71%), Postives = 79/99 (79.80%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTD--GKES 1023
            YK +S P      + INEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++ N   A+ T   GK+S
Sbjct:    3 YKFFSDP------SGINEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAANAKGASGTGSAGKKS 95

[Close]

BLAST of Paired like homeobox 2A vs. TrEMBL
Match: H0ZTN1 (Paired like homeobox 2A OS=Taeniopygia guttata OX=59729 GN=PHOX2A PE=4 SV=1)

HSP 1 Score: 144.05 bits (362), Expect = 6.651e-37
Identity = 70/99 (70.71%), Postives = 79/99 (79.80%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTD--GKES 1023
            YK +S P      + INEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++ N   A+ T   GK+S
Sbjct:    3 YKFFSDP------SGINEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAANAKGASGTGSSGKKS 95

[Close]

BLAST of Paired like homeobox 2A vs. TrEMBL
Match: A0A093QAD2 (Paired mesoderm homeobox protein 2A (Fragment) OS=Manacus vitellinus OX=328815 GN=N305_02968 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 1.388e-36
Identity = 74/110 (67.27%), Postives = 83/110 (75.45%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTD--GKESPSGSISPKRES 1056
            YK +S P      + INEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++ N   A+ T   GK+S   S S   ES
Sbjct:    3 YKFFSDP------SGINEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAANAKGASGTGTTGKKSEPRSSSEDDES 106

[Close]

BLAST of Paired like homeobox 2A vs. TrEMBL
Match: A0A1D2NBF2 (Paired mesoderm homeobox protein 2B OS=Orchesella cincta OX=48709 GN=Ocin01_04362 PE=4 SV=1)

HSP 1 Score: 143.665 bits (361), Expect = 1.545e-36
Identity = 70/94 (74.47%), Postives = 75/94 (79.79%), Query Frame = 1

Query:  715 FPNSN------SYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            FP  N      SYK+Y      D  + + EKRKQRRIRTTFTSAQLKELER+FQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   43 FPAMNLQAASLSYKMYG----GDASSVLTEKRKQRRIRTTFTSAQLKELERAFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKQER 132

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Match: phox2a (paired like homeobox 2A [Source:NCBI gene;Acc:103027382])

HSP 1 Score: 139.428 bits (350), Expect = 1.039e-37
Identity = 63/83 (75.90%), Postives = 71/83 (85.54%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            YK +S P      + +NEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++
Sbjct:   74 YKFFSDP------SGLNEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERA 150

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Match: phox2bb (paired like homeobox 2B [Source:NCBI gene;Acc:103032790])

HSP 1 Score: 137.887 bits (346), Expect = 3.422e-37
Identity = 69/95 (72.63%), Postives = 75/95 (78.95%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESD 1059
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++   + AA   G    SG  S  RE D
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKSG----SGKKSDSREED 181

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Match: arxa (aristaless related homeobox [Source:NCBI gene;Acc:103042910])

HSP 1 Score: 121.324 bits (303), Expect = 8.905e-30
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  222 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 286

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Match: arxb (aristaless-related homeobox protein-like [Source:NCBI gene;Acc:103045700])

HSP 1 Score: 120.553 bits (301), Expect = 2.681e-29
Identity = 55/80 (68.75%), Postives = 70/80 (87.50%), Query Frame = 1

Query:  742 YSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            +S+  DA+  T   +KRKQRR RTTFTS QL++LER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  262 FSAGSDAEDGT---QKRKQRRYRTTFTSYQLEQLERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 338

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Match: drgx (dorsal root ganglia homeobox [Source:NCBI gene;Acc:103032566])

HSP 1 Score: 107.842 bits (268), Expect = 3.796e-26
Identity = 53/88 (60.23%), Postives = 68/88 (77.27%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS---KNPSTAAMTDGKESPSGSIS 1041
            +RKQRR RTTFT  QL+ LE  F +THYPD++TREE+AMKI+LTEARVQVWFQNRRAK+RK E+    +  S   M++G  +P+ S+S
Sbjct:   39 RRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGSSDQEGSKEQMSEGA-APARSLS 125

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Match: dmbx1b (diencephalon/mesencephalon homeobox 1b [Source:NCBI gene;Acc:550288])

HSP 1 Score: 93.9745 bits (232), Expect = 2.084e-21
Identity = 40/62 (64.52%), Postives = 51/62 (82.26%), Query Frame = 1

Query:  796 QRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            QRR RT FT+ QL+ LE++FQ+THYPD+  RE +AM  +L EARVQVWF+NRRAKFRK ++S
Sbjct:   43 QRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRS 104

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010761.1 (pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-1 gene:ENSPMAG00000009746.1 transcript:ENSPMAT00000010761.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.8853 bits (211), Expect = 4.424e-21
Identity = 46/79 (58.23%), Postives = 57/79 (72.15%), Query Frame = 1

Query:  790 RKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESP 1026
            RKQRR RTTFT AQL  LE  F +T YPDI+ REE+A+KI+L E+RVQVWF+NRRAK R+ ++S   S A     K +P
Sbjct:    4 RKQRRERTTFTRAQLDVLEALFSKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGGQSKARAAKKKSTP 82

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Match: otx5 (orthodenticle homolog 5 [Source:ZFIN;Acc:ZDB-GENE-030508-1])

HSP 1 Score: 72.0182 bits (175), Expect = 1.900e-14
Identity = 35/58 (60.34%), Postives = 43/58 (74.14%), Query Frame = 1

Query:  790 RKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKF 963
            RKQRR RTTFT AQL +LE  F +T YPDI+ REE+A+KI+L E+RVQ+ F   R K 
Sbjct:   36 RKQRRERTTFTRAQL-DLESLFSKTRYPDIFMREEVALKINLPESRVQINFPESRVKL 92

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Match: dlx5a (distal-less homeobox 5a [Source:NCBI gene;Acc:30569])

HSP 1 Score: 72.7886 bits (177), Expect = 2.818e-14
Identity = 37/90 (41.11%), Postives = 56/90 (62.22%), Query Frame = 1

Query:  769 VTNINEKRKQ-RRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGS 1035
            V  +N K K+ R+ RT ++S QL  L+R FQ+T Y  +  R E+A  + LT+ +V++WFQNRR+KF+K+ K+       M   + SPS S
Sbjct:  192 VRMVNGKPKKIRKPRTIYSSFQLAALQRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKLGKNGE-----MAPAQASPSSS 276

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Match: MSX1 (msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391])

HSP 1 Score: 62.7734 bits (151), Expect = 2.709e-12
Identity = 26/69 (37.68%), Postives = 46/69 (66.67%), Query Frame = 1

Query:  778 INEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSK 984
            + + +  R+ RT FT++QL  LE  F++  Y  I  R E +  + LTE +V++WFQNRRAK +++++++
Sbjct:    8 LRKHKATRKPRTPFTTSQLLALEHKFRQKQYLSIAERAEFSTSLSLTETQVKIWFQNRRAKAKRLQEAE 76

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264])

HSP 1 Score: 53.1434 bits (126), Expect = 5.688e-8
Identity = 27/75 (36.00%), Postives = 40/75 (53.33%), Query Frame = 1

Query:  772 TNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPST 996
            +N ++   QR  RT      L  L+R F+    P +  R++I+  I + E  V++WFQNRRAK RK +   N  T
Sbjct:   69 SNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGSNKDT 143

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Match: EDO38926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH9])

HSP 1 Score: 107.071 bits (266), Expect = 2.411e-27
Identity = 46/64 (71.88%), Postives = 58/64 (90.62%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            KRK+RR RTTFT+ QL+E+ER FQ+THYPD+YTRE++A++  LTEARVQVWFQNRRAK+RK E+
Sbjct:   11 KRKKRRNRTTFTAYQLEEMERVFQKTHYPDVYTREQLALRCALTEARVQVWFQNRRAKWRKRER 74

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Match: EDO31796 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWY2])

HSP 1 Score: 103.219 bits (256), Expect = 4.742e-27
Identity = 51/66 (77.27%), Postives = 61/66 (92.42%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSK 984
            KRKQRR RTTFTS QL+ELER+F +THYPD++TRE +A+KIDLTEARVQVWFQNRRAK+RK EK++
Sbjct:   28 KRKQRRYRTTFTSYQLEELERAFAKTHYPDVFTREALAVKIDLTEARVQVWFQNRRAKWRKREKAQ 93

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Match: EDO42103 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2G7])

HSP 1 Score: 105.145 bits (261), Expect = 2.497e-26
Identity = 48/82 (58.54%), Postives = 64/82 (78.05%), Query Frame = 1

Query:  781 NEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESP 1026
             + RK RR RTTFT+ QL +LER+F++T YPD++TREE+A+++DL+EARVQVWFQNRRAK+RK EK+          G+ESP
Sbjct:   15 GKPRKVRRSRTTFTTYQLHQLERAFEKTQYPDVFTREELALRLDLSEARVQVWFQNRRAKWRKREKAL---------GRESP 87

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Match: EDO39160 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAY2])

HSP 1 Score: 98.9821 bits (245), Expect = 2.501e-25
Identity = 42/65 (64.62%), Postives = 56/65 (86.15%), Query Frame = 1

Query:  784 EKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            +K K+RR RT FT+ QL+ELE++F+E+HYPD+Y RE +++KIDL E R+QVWFQNRRAK+RK EK
Sbjct:    1 KKAKKRRHRTIFTNYQLEELEKAFKESHYPDVYARENLSLKIDLPEDRIQVWFQNRRAKWRKKEK 65

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Match: EDO42147 (Predicted protein; Retinal homeobox [Source:UniProtKB/TrEMBL;Acc:A7S2G8])

HSP 1 Score: 103.219 bits (256), Expect = 4.973e-25
Identity = 44/64 (68.75%), Postives = 56/64 (87.50%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            K+K RR RTTFT+ QL ELER+F+++HYPD+YTREE+A+KI L E RVQVWFQN+RAK+R+ EK
Sbjct:   82 KKKLRRNRTTFTTFQLHELERAFEKSHYPDVYTREELALKISLPEVRVQVWFQNKRAKWRREEK 145

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Match: phox2a (paired like homeobox 2A [Source:NCBI gene;Acc:101172183])

HSP 1 Score: 141.354 bits (355), Expect = 3.408e-38
Identity = 64/85 (75.29%), Postives = 72/85 (84.71%), Query Frame = 1

Query:  733 YKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKN 987
            YK +S P      + +NEKRKQRRIRTTFTS+QLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E++ N
Sbjct:   77 YKFFSDP------SGLNEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAN 155

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Match: phox2bb (paired like homeobox 2B [Source:NCBI gene;Acc:101165872])

HSP 1 Score: 136.732 bits (343), Expect = 1.224e-36
Identity = 60/68 (88.24%), Postives = 64/68 (94.12%), Query Frame = 1

Query:  775 NINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
             +NEKRKQRRIRTTFTSAQLKELER F ETHYPDIYTREE+A+KIDLTEARVQVWFQNRRAKFRK E+
Sbjct:   91 GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQER 158

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 121.709 bits (304), Expect = 7.539e-30
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 283

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 121.324 bits (303), Expect = 1.297e-29
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 283

[Close]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 120.939 bits (302), Expect = 2.203e-29
Identity = 52/65 (80.00%), Postives = 62/65 (95.38%), Query Frame = 1

Query:  787 KRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKS 981
            KRKQRR RTTFTS QL+ELER+FQ+THYPD++TREE+AM++DLTEARVQVWFQNRRAK+RK EK+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA 283

[Close]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Match: SMESG000052478.1 (SMESG000052478.1)

HSP 1 Score: 618.231 bits (1593), Expect = 0.000e+0
Identity = 378/378 (100.00%), Postives = 378/378 (100.00%), Query Frame = 1

Query:  121 MDYSNYSSIINTNYALTSYDDTLNCRLVSTTQFSSCPTGFSPITYSGSRNTNLGYDELFFDYSNPVLNIISSEFQLPSIVSTQXXXXXXXXXXXXXXXXXXXXXTRQFNNSYSNGAAAVMGLSNMYSGIXXXXXXXXXXXXXXXXSTLGCYGQPSYRNIXXXXXXXXXXXXXXXQLGSVAQNQIXXXXXXXXXXXXXMFPNSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESDLNLNSLNINKASEERNMFSQSDKFNSLLVSSSIASHADYMSKNHFLMGTSLSNLDLKLEESVFRP 1254
            MDYSNYSSIINTNYALTSYDDTLNCRLVSTTQFSSCPTGFSPITYSGSRNTNLGYDELFFDYSNPVLNIISSEFQLPSIVSTQLSSSLIESTCTSSSSSVPICSTRQFNNSYSNGAAAVMGLSNMYSGIQNQYLQHYNQQNQQLNSTLGCYGQPSYRNISSASLSYPHPPLSLSQLGSVAQNQINNLPLLKTPPLPNMFPNSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESDLNLNSLNINKASEERNMFSQSDKFNSLLVSSSIASHADYMSKNHFLMGTSLSNLDLKLEESVFRP
Sbjct:    1 MDYSNYSSIINTNYALTSYDDTLNCRLVSTTQFSSCPTGFSPITYSGSRNTNLGYDELFFDYSNPVLNIISSEFQLPSIVSTQLSSSLIESTCTSSSSSVPICSTRQFNNSYSNGAAAVMGLSNMYSGIQNQYLQHYNQQNQQLNSTLGCYGQPSYRNISSASLSYPHPPLSLSQLGSVAQNQINNLPLLKTPPLPNMFPNSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKESPSGSISPKRESDLNLNSLNINKASEERNMFSQSDKFNSLLVSSSIASHADYMSKNHFLMGTSLSNLDLKLEESVFRP 378

[Close]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 118.242 bits (295), Expect = 1.034e-28
Identity = 53/86 (61.63%), Postives = 69/86 (80.23%), Query Frame = 1

Query:  721 NSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            N+N Y+ Y      D+  +I  +RKQRR RTTFT  QL+ELE++FQ+THYPD++TREE+A++I LTEARVQVWFQNRRAK+RK E+
Sbjct:  118 NNNYYQHYG--FHHDLADDIFSRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTER 201

[Close]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 115.546 bits (288), Expect = 2.581e-28
Identity = 49/72 (68.06%), Postives = 63/72 (87.50%), Query Frame = 1

Query:  763 DIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            D+  +I  +RKQRR RTTFT  QL+ELE++FQ+THYPD++TREE+A++I LTEARVQVWFQNRRAK+RK E+
Sbjct:   26 DLADDIFSRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTER 97

[Close]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 115.546 bits (288), Expect = 2.746e-28
Identity = 49/72 (68.06%), Postives = 63/72 (87.50%), Query Frame = 1

Query:  763 DIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            D+  +I  +RKQRR RTTFT  QL+ELE++FQ+THYPD++TREE+A++I LTEARVQVWFQNRRAK+RK E+
Sbjct:   19 DLADDIFSRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTER 90

[Close]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Match: SMESG000033843.1 (SMESG000033843.1)

HSP 1 Score: 105.916 bits (263), Expect = 9.556e-26
Identity = 50/78 (64.10%), Postives = 63/78 (80.77%), Query Frame = 1

Query:  745 SSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 978
            SSP   D ++N N  +K RR RTTFT+ QL ELER+F+++HYPD+Y+REE+AMKI L E RVQVWFQNRRAK+R+ EK
Sbjct:   78 SSP---DRLSNCN--KKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKISLPEVRVQVWFQNRRAKWRRQEK 150

The following BLAST results are available for this feature:

BLAST of Paired like homeobox 2A vs. Ensembl Human
BLAST of Paired like homeobox 2A vs. Ensembl Celegans
BLAST of Paired like homeobox 2A vs. Ensembl Fly
BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
BLAST of Paired like homeobox 2A vs. Ensembl Mouse
BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
BLAST of Paired like homeobox 2A vs. TrEMBL
BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
BLAST of Paired like homeobox 2A vs. Ensembl Yeast
BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
BLAST of Paired like homeobox 2A vs. Ensembl Medaka
BLAST of Paired like homeobox 2A vs. Planmine SMEST

BLAST of Paired like homeobox 2A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PHOX2A	4.776e-36	75.61	paired like homeobox 2A [Source:HGNC Symbol;Acc:HG...	[more]
PHOX2B	1.839e-35	88.24	paired like homeobox 2B [Source:HGNC Symbol;Acc:HG...	[more]
ARX	1.117e-29	80.00	aristaless related homeobox [Source:HGNC Symbol;Ac...	[more]
ALX3	1.317e-26	55.67	ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449]	[more]
DRGX	1.744e-26	54.84	dorsal root ganglia homeobox [Source:HGNC Symbol;A...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ceh-17	5.462e-35	75.00	C. Elegans Homeobox; CEH-17 [Source:UniProtKB/TrE...	[more]
alr-1	2.999e-27	59.55	AristaLess (Drosophila homeodomain) Related [Sour...	[more]
unc-4	3.807e-23	55.26	Homeobox protein unc-4 [Source:UniProtKB/Swiss-Pr...	[more]
ceh-8	7.954e-23	66.67	Homeobox protein ceh-8 [Source:UniProtKB/Swiss-Pr...	[more]
ceh-10	1.147e-22	62.86	Homeobox protein ceh-10 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PHDP	3.440e-30	61.96	gene:FBgn0025334 transcript:FBtr0072224	[more]
al	1.076e-28	78.13	gene:FBgn0000061 transcript:FBtr0078053	[more]
Pph13	1.386e-28	76.56	gene:FBgn0023489 transcript:FBtr0078070	[more]
Drgx	1.792e-26	71.64	gene:FBgn0085369 transcript:FBtr0302391	[more]
Drgx	1.792e-26	71.64	gene:FBgn0085369 transcript:FBtr0339572	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
phox2bb	2.931e-37	71.58	paired like homeobox 2Bb [Source:ZFIN;Acc:ZDB-GENE...	[more]
phox2bb	6.829e-37	71.58	paired like homeobox 2Bb [Source:ZFIN;Acc:ZDB-GENE...	[more]
phox2bb	6.829e-37	71.58	paired like homeobox 2Bb [Source:ZFIN;Acc:ZDB-GENE...	[more]
phox2a	2.414e-36	75.61	paired like homeobox 2A [Source:ZFIN;Acc:ZDB-GENE-...	[more]
arxb	1.141e-29	81.25	aristaless related homeobox b [Source:ZFIN;Acc:ZDB...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
phox2a	1.599e-37	77.11	paired like homeobox 2A [Source:NCBI gene;Acc:1004...	[more]
polr2a	1.158e-36	88.24	polymerase (RNA) II (DNA directed) polypeptide A, ...	[more]
polr2a	1.158e-36	88.24	polymerase (RNA) II (DNA directed) polypeptide A, ...	[more]
ARX	1.158e-29	80.00	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
vill	4.131e-29	41.86	villin like [Source:Xenbase;Acc:XB-GENE-945607]	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Phox2a	1.405e-36	75.61	paired-like homeobox 2a [Source:MGI Symbol;Acc:MGI...	[more]
Phox2b	1.263e-35	88.24	paired-like homeobox 2b [Source:MGI Symbol;Acc:MGI...	[more]
Arx	1.600e-29	80.00	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Arx	1.600e-29	80.00	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Prrxl1	4.100e-27	54.84	paired related homeobox protein-like 1 [Source:MGI...	[more]

BLAST of Paired like homeobox 2A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q62066\|PHX2A_MOUSE	9.825e-36	75.61	Paired mesoderm homeobox protein 2A OS=Mus musculu...	[more]
sp\|Q62782\|PHX2A_RAT	1.616e-35	75.61	Paired mesoderm homeobox protein 2A OS=Rattus norv...	[more]
sp\|O14813\|PHX2A_HUMAN	2.294e-35	75.61	Paired mesoderm homeobox protein 2A OS=Homo sapien...	[more]
sp\|O35690\|PHX2B_MOUSE	8.833e-35	88.24	Paired mesoderm homeobox protein 2B OS=Mus musculu...	[more]
sp\|Q99453\|PHX2B_HUMAN	8.833e-35	88.24	Paired mesoderm homeobox protein 2B OS=Homo sapien...	[more]

BLAST of Paired like homeobox 2A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A336MU29	4.921e-37	70.00	CSON006710 protein (Fragment) OS=Culicoides sonore...	[more]
U3JUS3	6.230e-37	70.71	Paired like homeobox 2A OS=Ficedula albicollis OX=...	[more]
H0ZTN1	6.651e-37	70.71	Paired like homeobox 2A OS=Taeniopygia guttata OX=...	[more]
A0A093QAD2	1.388e-36	67.27	Paired mesoderm homeobox protein 2A (Fragment) OS=...	[more]
A0A1D2NBF2	1.545e-36	74.47	Paired mesoderm homeobox protein 2B OS=Orchesella ...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
phox2a	1.039e-37	75.90	paired like homeobox 2A [Source:NCBI gene;Acc:1030...	[more]
phox2bb	3.422e-37	72.63	paired like homeobox 2B [Source:NCBI gene;Acc:1030...	[more]
arxa	8.905e-30	80.00	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arxb	2.681e-29	68.75	aristaless-related homeobox protein-like [Source:N...	[more]
drgx	3.796e-26	60.23	dorsal root ganglia homeobox [Source:NCBI gene;Acc...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmbx1b	2.084e-21	64.52	diencephalon/mesencephalon homeobox 1b [Source:NCB...	[more]
ENSPMAT00000010761.1	4.424e-21	58.23	pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-...	[more]
otx5	1.900e-14	60.34	orthodenticle homolog 5 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
dlx5a	2.818e-14	41.11	distal-less homeobox 5a [Source:NCBI gene;Acc:3056...	[more]
MSX1	2.709e-12	37.68	msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PHO2	5.688e-8	36.00	Homeobox transcription factor; regulatory targets ...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38926	2.411e-27	71.88	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31796	4.742e-27	77.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42103	2.497e-26	58.54	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39160	2.501e-25	64.62	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42147	4.973e-25	68.75	Predicted protein; Retinal homeobox [Source:UniPr...	[more]

BLAST of Paired like homeobox 2A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
phox2a	3.408e-38	75.29	paired like homeobox 2A [Source:NCBI gene;Acc:1011...	[more]
phox2bb	1.224e-36	88.24	paired like homeobox 2B [Source:NCBI gene;Acc:1011...	[more]
arx	7.539e-30	80.00	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	1.297e-29	80.00	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	2.203e-29	80.00	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]

BLAST of Paired like homeobox 2A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000052478.1	0.000e+0	100.00	SMESG000052478.1	[more]
SMESG000080420.1	1.034e-28	61.63	SMESG000080420.1	[more]
SMESG000080420.1	2.581e-28	68.06	SMESG000080420.1	[more]
SMESG000080420.1	2.746e-28	68.06	SMESG000080420.1	[more]
SMESG000033843.1	9.556e-26	64.10	SMESG000033843.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013056 ID=SMED30013056|Name=Paired like homeobox 2A|organism=Schmidtea mediterranea sexual|type=transcript|length=1336bp
GCACAACTGAAAAATTCGAATAGAATACAAATTAAATAAATACCTTAACT
CGAAATTAACCTAGTTATTAAACCAGATTTTCTTGGAGAAAATTCCTAAT
TTAATTGACCGGGTATACCGATGGACTATAGCAATTATTCATCTATTATC
AACACTAATTACGCTCTAACAAGTTACGATGATACTCTCAACTGCCGATT
GGTATCAACGACACAATTTTCCAGTTGCCCAACCGGGTTTTCACCGATTA
CTTATTCCGGTTCCCGCAATACCAATCTCGGATATGATGAACTATTTTTC
GACTATTCCAATCCAGTTTTGAACATAATTTCCAGTGAGTTTCAACTGCC
ATCTATCGTTTCGACTCAGTTAAGCTCATCACTGATCGAGTCGACTTGCA
CATCATCGTCTTCATCCGTTCCGATATGTAGCACGAGACAATTCAACAAT
TCCTATTCCAACGGAGCAGCCGCCGTGATGGGCCTCTCTAACATGTACAG
TGGAATTCAAAACCAATATTTACAACATTATAATCAACAAAATCAACAGT
TAAATTCGACTCTTGGTTGTTACGGTCAACCGTCTTATCGAAATATTAGT
TCAGCTTCTCTTTCATATCCTCACCCCCCATTGAGTTTGTCTCAATTAGG
GAGTGTGGCTCAGAATCAAATCAACAATCTTCCATTATTAAAAACTCCTC
CACTGCCGAATATGTTTCCCAATTCAAATAGTTACAAACTGTATTCATCG
CCAGTTGATGCTGATATTGTGACTAATATCAATGAGAAAAGAAAACAACG
AAGAATTCGGACGACATTCACAAGTGCTCAACTGAAAGAGTTAGAAAGAT
CATTTCAAGAAACTCATTATCCTGATATTTATACTCGTGAAGAGATTGCA
ATGAAGATCGATTTGACTGAAGCTCGAGTCCAGGTTTGGTTTCAAAATAG
ACGAGCAAAATTTAGGAAAATGGAAAAGTCCAAGAACCCTTCGACAGCAG
CGATGACTGATGGTAAGGAAAGCCCTTCTGGTTCGATAAGCCCAAAGCGG
GAAAGCGACTTGAATCTAAACTCGCTGAACATTAATAAAGCGAGTGAAGA
AAGAAACATGTTCTCTCAATCGGATAAATTCAATTCCCTTCTCGTTTCTT
CGTCAATCGCGTCCCATGCAGATTACATGTCAAAAAATCACTTCCTAATG
GGGACTTCTTTGTCAAACTTAGATTTGAAACTCGAGGAATCTGTTTTTAG
ACCTTAAATTAAATTCTCGTCAAATTTTCATATGATTATAAACGTCAATA
TTTTCACTGTCAATAGTTTTATTCTCTAATAAATGC

protein sequence of SMED30013056-orf-1

>SMED30013056-orf-1 ID=SMED30013056-orf-1|Name=SMED30013056-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=379bp
MDYSNYSSIINTNYALTSYDDTLNCRLVSTTQFSSCPTGFSPITYSGSRN
TNLGYDELFFDYSNPVLNIISSEFQLPSIVSTQLSSSLIESTCTSSSSSV
PICSTRQFNNSYSNGAAAVMGLSNMYSGIQNQYLQHYNQQNQQLNSTLGC
YGQPSYRNISSASLSYPHPPLSLSQLGSVAQNQINNLPLLKTPPLPNMFP
NSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHY
PDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEKSKNPSTAAMTDGKE
SPSGSISPKRESDLNLNSLNINKASEERNMFSQSDKFNSLLVSSSIASHA
DYMSKNHFLMGTSLSNLDLKLEESVFRP*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002111	X2 cell
PLANA:0003117	parapharyngeal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0003358	noradrenergic neuron development
GO:0007420	brain development
GO:0021703	locus ceruleus development
GO:0048666	neuron development

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 226..288 e-value: 1.8E-27 score: 107.3
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 227..283 e-value: 3.0E-23 score: 81.4
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 224..284 score: 21.038
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 227..285 e-value: 2.75248E-24 score: 92.3064
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 219..289 e-value: 3.8E-30 score: 105.3
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 283..315
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 289..315
None	No IPR available	PANTHER	PTHR24329	FAMILY NOT NAMED	coord: 133..332
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 259..282
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 207..286

Main menu

Paired like homeobox 2A

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Owlery

blazegraph-runner